Classifications

• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
  • A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
  • A01N37/02—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
  • A01N37/06—Unsaturated carboxylic acids or thio analogues thereof; Derivatives thereof
• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
  • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
  • C11D1/38—Cationic compounds
  • C11D1/42—Amino alcohols or amino ethers
  • C11D1/44—Ethers of polyoxyalkylenes with amino alcohols; Condensation products of epoxyalkanes with amines
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
  • C11D1/66—Non-ionic compounds
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
  • C11D1/66—Non-ionic compounds
  • C11D1/72—Ethers of polyoxyalkylene glycols
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D10/00—Compositions of detergents, not provided for by one single preceding group
  • C11D10/04—Compositions of detergents, not provided for by one single preceding group based on mixtures of surface-active non-soap compounds and soap
  • C11D10/045—Compositions of detergents, not provided for by one single preceding group based on mixtures of surface-active non-soap compounds and soap based on non-ionic surface-active compounds and soap
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
  • C11D3/16—Organic compounds
  • C11D3/20—Organic compounds containing oxygen
  • C11D3/2075—Carboxylic acids-salts thereof
  • C11D3/2079—Monocarboxylic acids-salts thereof
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
  • C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions

Definitions

• the invention relates to antimicrobial compositions including carboxylic acids, such as fatty acid antimicrobial agents, and a non-ionic surfactant, such as an ethoxylated amine.
• carboxylic acids such as fatty acid antimicrobial agents
• non-ionic surfactant such as an ethoxylated amine.
• the compositions can be used to clean surfaces, including for example, a solid shower cleaner and disinfectant composition and methods of use thereof.
• antimicrobial agents having improved efficacy and non-irritating and non-corrosive characteristics.
• the specific requirements for such agents vary according to the intended application (e.g., sanitizer, disinfectant, cleaner, sterilant, etc.) and the applicable public health requirements.
• sanitizer e.g., sanitizer, disinfectant, cleaner, sterilant, etc.
• public health requirements e.g., sanitizer, disinfectant, cleaner, sterilant, etc.
• a sanitizer should provide a 99.999% reduction (5-log order reduction) within 30 seconds at room temperature against several test organisms, whereas a disinfectant should kill all vegetative cells including most recognized pathogenic microorganisms.
• the present invention relates to antimicrobial compositions comprising, consisting of and/or consisting essentially of a fatty acid antimicrobial agent and an ethoxylated amine surfactant or coupling agent, and to methods of using such antimicrobial compositions.
• An advantage of the invention provides a compatible coupler for saturated fatty acids, such as decanoic acid, in an aqueous solvent.
• Compositions according to the invention provide a solid, high bio-based, cost-effective, non-irritating and non-corrosive antimicrobial cleaner, which may be used to provide a stable aqueous use solution.
• the invention comprises a composition having from about 0.05 wt-% to about 20 wt-% carboxylic acid antimicrobial agent and from about 0.1 wt-% to about 30 wt-% nonionic surfactant, wherein the nonionic surfactant and carboxylic acid antimicrobial agent have a weight ratio of about 5.5:1 to about 3:1 and the composition is clear and has effective antimicrobial activity.
• the invention comprises a composition having from about 0.05 wt-% to about 10 wt-% fatty acid antimicrobial agent and from about 0.15 wt-% to about 55 wt-% ethoxylated amine of one of the following formulas:
• the ethoxylated amine and fatty acid antimicrobial agent being at a weight ratio of about 5.5:1 to about 3:1, and wherein the composition is clear and has effective antimicrobial activity.
• a method of reducing a microbial population on an object comprises contacting the object with a composition comprising: from about 0.05 wt-% to about 10 wt-% fatty acid antimicrobial agent and from about 0.15 wt-% to about 55 wt-% ethoxylated amine of one of the following formulas:
• the ethoxylated amine and fatty acid antimicrobial agent being at a weight ratio of about 5.5:1 to about 3:1, and wherein the composition is clear and has effective antimicrobial activity.
• compositions can also include additional and optional ingredients, such as a solvent, diluent, sequestrant, acidulant, or other adjuvant such as a stabilizing agent, wetting agent, thickener, foaming agent, pigment and dye, or mixtures thereof.
• compositions and methods of the invention are especially useful as antimicrobial compositions for use as sterilants, sanitizers, disinfectants, soap scum remover, lime remover, delimer, hand wash and sanitizer and other cleaners.
• the compositions and methods have particular utility as a shower cleaner, disinfectant and sanitizer.
• the antimicrobial compositions and methods have further utility in a variety of healthcare and food service applications.
• compositions according to the invention provide many advantages over conventional cleaning products.
• compositions according to the invention provide a solid, highly bio-based, cost-effective, shower cleaner and disinfectant that is both non-irritating and non-corrosive.
• the present invention provides these numerous advantages along with demonstrating improved efficacy against Staphylococcus aureus and other bacteria.
• the compositions of the invention When applied to microbes (e.g., when applied to a surface containing microbes), the compositions of the invention exhibit antimicrobial action. The mechanism by which such action takes place is not completely understood. However, as shown in the Examples set out below, very rapid and substantially complete antimicrobial action is attained according to the compositions and methods according to the invention.
• the term “about,” as used herein, refers to variation in the numerical quantity that can occur, for example, through typical measuring and liquid handling procedures used for making concentrates or use solutions in the real world; through inadvertent error in these procedures; through differences in the manufacture, source, or purity of the ingredients used to make the compositions or carry out the methods; and the like.
• the term “about” also encompasses amounts that differ due to different equilibrium conditions for a composition resulting from a particular initial mixture. Whether or not modified by the term “about”, the claims include equivalents to the quantities refers to variation in the numerical quantity that can occur.
• Term “antimicrobial composition,” as used herein, refers to a composition having the ability to cause greater than a 90% reduction (1-log order reduction) in the population of bacteria or spores.
• the antimicrobial compositions of the invention provide greater than a 99% reduction (2-log order reduction), more preferably greater than a 99.99% reduction (4-log order reduction), and most preferably greater than a 99.999% reduction (5-log order reduction) in such population within 10 minutes at 60° C.
• the antimicrobial compositions of the invention provide greater than a 99% reduction (2-log order reduction), more preferably greater than a 99.99% reduction (4-log order reduction), and most preferably greater than a 99.999% reduction (5-log order reduction) in the population of one or more additional organisms. Because in their broadest sense these definitions for antimicrobial activity are different from some of the current governmental regulations, the use in connection with this invention of the term “antimicrobial” is not intended to indicate compliance with any particular governmental standard for antimicrobial activity.
• Antimicrobial compositions can affect two kinds of microbial cell damage. The first is a lethal, irreversible action resulting in complete microbial cell destruction or incapacitation. The second type of cell damage is reversible, such that if the organism is rendered free of the agent, it can again multiply.
• the former is termed bacteriocidal and the later, bacteriostatic.
• a sanitizer and a disinfectant are, by definition, agents which provide antibacterial or bacteriocidal activity.
• a preservative is generally described as an inhibitor or bacteriostatic composition.
• the term “disinfectant” refers to an agent that kills all vegetative cells including most recognized pathogenic microorganisms, using the procedure described in AOAC Use Dilution Methods, Official Methods of Analysis of the Association of Official Analytical Chemists, paragraph 955.14 and applicable sections, 15th Edition, 1990 (EPA Guideline 91-2).
• health care surface refers to a surface of an instrument, a device, a cart, a cage, furniture, a structure, a building, or the like that is employed as part of a health care activity.
• Examples of health care surfaces include surfaces of medical or dental instruments, of medical or dental devices, of electronic apparatus employed for monitoring patient health, and of floors, walls, or fixtures of structures in which health care occurs. Health care surfaces are found in hospital, surgical, infirmity, birthing, mortuary, and clinical diagnosis rooms.
• These surfaces can be those typified as “hard surfaces” (such as walls, floors, bed-pans, etc.,), or woven and non-woven surfaces (such as surgical garments, draperies, bed linens, bandages, etc.,), or patient-care equipment (such as respirators, diagnostic equipment, shunts, body scopes, wheel chairs, beds, etc.), or surgical and diagnostic equipment.
• Health care surfaces include articles and surfaces employed in animal health care.
• instrument refers to the various medical or dental instruments or devices that can benefit from cleaning with a high concentration composition according to the present invention.
• the phrases “medical instrument”, “dental instrument”, “medical device”, “dental device”, “medical equipment”, or “dental equipment” refer to instruments, devices, tools, appliances, apparatus, and equipment used in medicine or dentistry. Such instruments, devices, and equipment can be cold sterilized, soaked or washed and then heat sterilized, or otherwise benefit from cleaning in a composition of the present invention. These various instruments, devices and equipment include, but are not limited to: diagnostic instruments, trays, pans, holders, racks, forceps, scissors, shears, saws (e.g.
• hemostats knives, chisels, rongeurs, files, nippers, drills, drill bits, rasps, burrs, spreaders, breakers, elevators, clamps, needle holders, carriers, clips, hooks, gouges, curettes, retractors, straightener, punches, extractors, scoops, keratomes, spatulas, expressors, trocars, dilators, cages, glassware, tubing, catheters, cannulas, plugs, stents, arthoscopes and related equipment, and the like, or combinations thereof.
• microorganisms refers to any noncellular or unicellular (including colonial) organism. Microorganisms include all prokaryotes. Microorganisms include bacteria (including cyanobacteria and Mycobacteria), lichens, microfungi, protozoa, virinos, viroids, viruses, fungi (e.g., molds and yeast), and some algae. As used herein, the term “microbe” is synonymous with microorganism.
• Objects refers to something material that can be perceived by the senses, directly and/or indirectly.
• Objects include a surface, including a hard surface (such as glass, ceramics, metal, natural and synthetic rock, wood, and polymeric), an elastomer or plastic, woven and non-woven substrates, a food processing surface, a health care surface, and the like.
• Objects also include a food product (and its surfaces); a body or stream of water or a gas (e.g., an air stream); and surfaces and articles employed in hospitality and industrial sectors.
• sanitizer refers to an agent that reduces the number of bacterial contaminants to safe levels as judged by public health requirements.
• sanitizers for use in this invention will provide at least a 99.999% reduction (5-log order reduction) using the Germicidal and Detergent Sanitizing Action of Disinfectants procedure referred to above.
• sterilant refers to a physical or chemical agent or process capable of destroying all forms of life (including bacteria, viruses, fungi, and spores) on inanimate surfaces.
• AOAC Sporicidal Activity of Disinfectants Official Methods of Analysis of the Association of Official Analytical Chemists, paragraph 966.04 and applicable sections, 15th Edition, 1990 (EPA Guideline 91-2).
• weight percent refers to the concentration of a substance as the weight of that substance divided by the total weight of the composition and multiplied by 100. It is understood that, as used here, “percent,” “%,” and the like are intended to be synonymous with “weight percent,” “wt-%,” etc.
• compositions and methods of the present invention may comprise, consist essentially of, or consist of the component and ingredients of the present invention as well as other ingredients described herein.
• “consisting essentially of” means that the methods, systems, apparatuses and compositions may include additional steps, components or ingredients, but only if the additional steps, components or ingredients do not materially alter the basic and novel characteristics of the claimed methods, systems, apparatuses, and compositions.
• compositions including Medium Chain Fatty Acid Antimicrobial Agents and Suitable Coupling Agents
• the present invention relates to antimicrobial compositions including antimicrobial agents, namely fatty acids, and a coupling agent, such as an ethoxylated amine.
• antimicrobial agents namely fatty acids
• a coupling agent such as an ethoxylated amine
• the combination of the ethoxylated amine and fatty acid antimicrobial agent maintains solubility of the fatty acid within the composition as a result of the solubility profile and HLB of the ethoxylated amine, along with the ratio of the composition components.
• the fatty acid antimicrobial agent is immediately dispersed and soluble upon dilution with water.
• the antimicrobial compositions demonstrate sufficient temperature stability while fully solubilizing the antimicrobial fatty acid.
• the ethoxylated amine coupler for the fatty acid antimicrobial agent is stable at temperatures of at least about 50° F. to 120° F.
• a stable and clear composition is formed, retaining the antimicrobial activity of the fatty acid, providing ideal shower and bath disinfectants, detergents and other cleaning compositions.
• the present composition employs the ethoxylated amine surfactant to effectively couple the fatty acid antimicrobial agent into an aqueous solvent.
• the ethoxylated amine is capable of coupling the fatty acid into acidic compositions without complexing or reacting with the fatty acid, forming a clear and stable aqueous use solution that provides effective soil removal.
• compositions of the present invention can include an antimicrobial agent such as a lipid, a fatty acid and/or a low HLB antimicrobial agent.
• suitable antimicrobial agents include fatty acid or carboxylic acid antimicrobial agents.
• preferred fatty acid antimicrobial agents include medium chain fatty acids, including C 6 -C 16 alkyl carboxylic acids, such as hexanoic acid, butyric acid, octanoic acid, heptanoic acid, nonionic acid, and decanoic acid.
• the fatty acid antimicrobial agent an C 8 -C 12 alkyl carboxylic acid, still more preferably C 9 -C 10 alkyl carboxylic acid, such as decanoic acid (capric acid). It is to be understood that mixtures of antimicrobial agents can be used if desired.
• suitable fatty acid antimicrobial agents include an aliphatic or aromatic fatty acid, either saturated or unsaturated, having from about 6 to about 16 carbon atoms, or mixtures of these fatty acids.
• the aliphatic fatty acid is saturated.
• the fatty acid includes about 8 to about 12 carbon atoms.
• the fatty acid includes about 9 to about 10 carbon atoms.
• the fatty acid can be linear, branched or cyclic and can contain substituent atoms such as hydroxyl groups or ether linkages as long as the substituents do not affect antimicrobial activity.
• Suitable fatty acids include, for example, hexanoic acid, heptanoic acid, octanoic acid, nonanoic acid, decanoic acid, dodecanoic acid, myristic acid, or mixtures thereof.
• the fatty acid includes heptanoic acid, octanoic acid, nonanoic acid, decanoic acid, dodecanoic acid, or mixtures thereof.
• the fatty acid preferably includes decanoic acid.
• compositions of the invention contain sufficient antimicrobial agent to achieve the desired rate and efficacy for microbial reduction from a solid concentrated composition.
• the antimicrobial agent can be present in a solid concentrated composition 0.1 to about 35 wt-%, about 0.1 to about 30 wt-%, about 0.1 to about 25 wt-%, about 0.1 to about 20 wt-%, about 0.1 to about 15 wt-%, about 0.1 to about 10 wt-%, about 0.5 to about 10 wt-%, about 0.5 to about 7 wt-%, or about 0.5 to about 5 wt-%.
• the antimicrobial agent can be present at any of these amounts not as part of a range and/or at any of these amounts not modified by about.
• compositions of the invention may further contain sufficient antimicrobial agent to achieve the desired rate and efficacy for microbial reduction from a use solution composition.
• the antimicrobial agent can be present in a use composition, such as a use solution at about 0.05 to about 25 wt-%, about 0.07 to about 20 wt-%, about 0.07 to about 5 wt-%, about 0.05 to about 3 wt-%, about 0.07 to about 3 wt-%, about 0.05 to about 15 wt-%, about 0.1 to about 25 wt-%, about 0.1 to about 20 wt-%, about 0.1 to about 10 wt-%, about 0.1 to about 5 wt-%, about 0.1 to about 4 wt-%, about 0.1 to about 3 wt-%, or about 0.1 to about 15 wt-%.
• the antimicrobial agent can be present at any of these amounts not as part of a range and/or at any of these amounts not modified by about.
• the antimicrobial compositions of the invention may optionally be formulated to contain an additional antimicrobial agent.
• This additional antimicrobial agent can be dissolved or dispersed in the antimicrobially-active solvent or in a diluting solvent.
• Suitable additional antimicrobial agents include carboxylic acids, diacids, or triacids (e.g., butyric acid, heptanoic acid, octanoic acid, nonanoic acid, decanoic acid, salycic acid, mandelic acid, succinic acid, adipic acid, glutaric acid, EDTA and citric acid or isomers thereof), carboxylic esters (e.g., p-hydroxy alkyl benzoates and alkyl cinnamates), sulfonic acids (e.g., dodecylbenzene sulfonic acid), iodo-compounds or active halogen compounds (e.g., iodine, interhalides,
• compositions according to the invention can be employed for use in the compositions according to the invention to provide a coupler for the fatty acid antimicrobial agent, such as decanoic acid, in an aqueous solvent.
• the surfactant identity and use level is selected based upon the characteristics of the antimicrobial agent, including the solubility of the fatty acid antimicrobial agent.
• Preferred compositions according to the invention employ a surfactant with a sufficiently high HLB value to provide adequate solubility, without oversolubilization result in the complexing of the antimicrobial agent (i.e. wherein the antimicrobial agent is within a micelle and unable to provide antimicrobial effects against microbes contacted with the composition).
• the HLB represents the empirical expression for the hydrophilic and hydrophobic groups of the surfactant, wherein the higher the HLB value the more water-soluble the surfactant.
• the HLB of the surfactant is greater than or equal to about 7 to about 14, preferably from about 7.5 to about 14, more preferably from about 10 to about 14 or from about 11 to about 14, or still further from about 12 to about 14.
• the surfactant according to the invention does not cause formation of insoluble deposits, and has low odor and low toxicity. Mixtures of surfactants can be used if desired in order to obtain the desired HLB of the one or more surfactants.
• the composition includes a nonionic surfactant, preferably an ethoxylated amine used in combination with the fatty acid antimicrobial.
• a nonionic surfactant preferably an ethoxylated amine used in combination with the fatty acid antimicrobial.
• the ratio of the ethoxylated amine to antimicrobial agent is tailored to provide suitable coupling for maintained solubility and antimicrobial activity of the fatty acid component.
• the ratio of ethoxylated amine to antimicrobial agent ranges from about 9:1 to about 1:1 (ethoxylated amine to fatty acid antimicrobial agent), about 8:1 to about 1:1, about 7:1 to about 2:1, about 6:1 to about 2:1, about 5.5:1 to about 3:1, about 5.5:1 to about 4.5:1, about 4.5:1 to about 3:1, or about 4.5:1.
• the ratio of ethoxylated amine to the decanoic acid antimicrobial agent in an aqueous solvent is between about 4.5:1 to
• compositions can include any of a variety of ethoxylated amines.
• the ethoxylated amine may be branched or unbranched according to one of the following formulas:
• R can be a straight or branched alkyl or alkylaryl substituent.
• R can be a substituent having from 1 to 24 carbon atoms and each n can be from 1 to 20.
• n is from 1 to 16, from 1 to 15, from 1 to 14, from 1 to 13, from 1 to 12, from 1 to 11, from 1 to 10, from 1 to 9, from 1 to 8, from 1 to 6, from 1 to 5, from 1 to 4, or from 1 to 3.
• R is derived from coconut oil and n is between 1 to 14, preferably between 6 to 12 and has an HLB from approximately 10 to 14.
• the total EO groups (n+n) are preferably between 6 to 12 or 6 to 10.
• R can be capped or terminated with ethylene oxide, propylene oxide, or butylene oxide units.
• a suitable CAS number for an ethoxylated amine according to the invention is 61791-14-8.
• the R groups of the ethoxylated amine provide sufficient solubility to stabilize and solubilize the fatty acid antimicrobial agent within an aqueous solution.
• the surfactant does not include an alcohol and is a medium to short chain carbon group having less than 24 carbon atoms.
• the ethoxylated amine is a cocoamine. Ethoxylated cocoamines are commercially available, for example, under tradenames such as Varonic (Evonik Industries) and Toximul (Stepan Company), including Varonic K-210 and Toximul CA 7.5.
• the ethoxylated amine is selected according to an R group substituent providing suitable solubility to ensure the maintained physical stability of the antimicrobial fatty acid, such as decanoic acid.
• the solubility of the R group of the ethoxylated amine obviates the need for increased ethoxylated amine to antimicrobial agent ratio beyond approximately 3.5:1 to about 5.5:1.
• the ethoxylated cocoamine provides physical stability to a concentrate or use antimicrobial composition, while retaining the solubility and clarity of the concentrate or use solution, and/or without inhibiting action of the fatty acid antimicrobial agent.
• the composition includes an ethoxylated cocoamine as the primary solubilizing (coupling) or emulsifying agent.
• compositions of the invention contain sufficient ethoxylated amine surfactant to achieve the desired solubility of the use solution without interfering with the efficacy of microbial reduction.
• the ethoxylated amine can be present in a solid concentrate composition at about 0.2 to about 95 wt-%, about 0.3 to about 95 wt-%, about 0.4 to about 95 wt-%, about 0.2 to about 90 wt-%, about 0.2 to about 60 wt-%, about 1 to about 60 wt-%, about 1 to about 50 wt-%, about 1 to about 30 wt-%, or about 1 to about 20 wt-%.
• the antimicrobial agent can be present at any of these amounts not as part of a range and/or at any of these amounts not modified by about.
• compositions of the invention contain sufficient ethoxylated amine surfactant to achieve the desired solubility of the use solution without interfering with the efficacy of microbial reduction.
• the ethoxylated amine can be present in a use composition, such as a use solution at about 0.005 to about 25 wt-%, about 0.01 to about 20 wt-%, about 0.01 to about 5 wt-%, about 0.015 to about 3 wt-%, about 0.03 to about 3 wt-%, about 0.05 to about 15 wt-%, about 0.1 to about 25 wt-%, about 0.1 to about 20 wt-%, about 0.1 to about 10 wt-%, about 0.2 to about 10 wt-%, about 0.4 to about 10 wt-%, about 0.4 to about 5 wt-%, about 0.4 to about 20 wt-%, about 0.4 to about 5 wt-%, about 0.4 to about 4 wt-%, about
• the antimicrobial composition comprises, consists of or consists essentially of a nonionic surfactant and a carboxylic acid antimicrobial agent, wherein the nonionic surfactant has a narrow range of HLB values, sufficiently soluble R group, and a surfactant to antimicrobial agent ratio that retains full antimicrobial efficacy of the carboxylic acid antimicrobial agent, such as decanoic acid.
• the composition comprises about 0.05 wt-% to about 20 wt-% carboxylic acid antimicrobial agent, and about 0.1 wt-% to about 30 wt-% nonionic surfactant, wherein the nonionic surfactant and carboxylic acid antimicrobial agent have a weight ratio of about 5.5:1 to about 3:1 and the composition is clear and has effective antimicrobial activity.
• the carboxylic acid antimicrobial agent is a C 6 -C 16 alkyl carboxylic acid, salt or ester thereof, including for example wherein the C 6 -C 12 alkyl carboxylic acid comprises octanoic acid, heptanoic acid, nonanoic acid, decanoic acid, dodecanoic acid, myristic acid, isomers thereof, or mixtures thereof.
• the nonionic surfactant is an ethoxylated amine and the antimicrobial agent is decanoic acid and the ratio of ethoxylated amine to decanoic acid is about 4.5:1.
• the composition comprises about 0.05 wt-% to about 10 wt-% fatty acid antimicrobial agent, about 0.15 wt-% to about 55 wt-% ethoxylated amine of one of the following formulas:
• the ethoxylated amine and fatty acid antimicrobial agent have a weight ratio of about 5.5:1 to about 3:1, and wherein the composition is clear and has effective antimicrobial activity.
• the fatty acid antimicrobial agent comprises octanoic acid, heptanoic acid, nonanoic acid, decanoic acid, dodecanoic acid, myristic acid, isomers thereof, or mixtures thereof and the ethoxylated amine has a hydrophile-lipohile balance (HLB) from about 7.5 to about 14.
• HLB hydrophile-lipohile balance
• the HLB of the ethoxylated amine is from about 10 to about 14 and the R group of the ethoxylated amine is a substituent comprising a mixture of saturated and unsaturated fatty acids with 6-18 carbons. More preferably the R group is a substituent derived from coconut oil. Still further, according to an embodiment the ration of ethoxylated amine and fatty acid antimicrobial agent is about 5.5:1 to about 3:1.
• the present compositions can include one or more ingredient to decrease the pH, e.g. one or more acids or acidulants.
• Suitable acids include organic and inorganic acids.
• suitable inorganic acids include phosphoric acid, hydrochloric acid, nitric acid, sulfuric acid, sulfamic acid, mixtures thereof, or the like.
• suitable organic acids include lactic acid, citric acid, propionic acid, acetic acid, hydroxyacetic acid, formic acid, glutaric acid, malic acid, hydroxy propionic acid, succinic acid, glutaric acid, adipic acid, fumaric acid, mixtures thereof, or the like.
• the acid includes phosphoric acid, lactic acid, or a mixture thereof.
• the acid includes phosphoric acid, lactic acid, hydroxyacetic acid, or a mixture thereof.
• the acid includes citric acid, lactic acid, urea hydrochloride, or a mixture thereof.
• a variety of fluids can be used as the diluting solvent, including water in its liquid form.
• the compositions of the invention can be formulated to include the diluting solvent (e.g., water) as sold, or the diluting solvent can be added at any time up to the time of use.
• the concentrates of the invention contain little or no diluting solvent as sold.
• a variety of dilution ratios can be employed, so long as the diluted composition exhibits the desired antimicrobial behavior when applied to the target microbes.
• the ingredients in the concentrate can represent about 1 to about 99 wt-% of the diluted mixture.
• the diluted composition preferably contains antimicrobially-active solvent in an amount near the solubility limit of the antimicrobially-active solvent in the diluting solvent.
• the diluted antimicrobial compositions preferably are aqueous, contain additional antimicrobial agent, and are clear or quasi-stable. For example, water can be used to dilute an antimicrobial composition to a preferred use concentration of approximately 3%.
• the present compositions can include one or more solvents including organic and aqueous solvents.
• suitable organic solvents include isopropanol, other lower alcohols, glycol ethers, mixtures thereof, or the like.
• suitable aqueous solvents include water, mixtures of water with the organic solvent, mixtures thereof, or the like.
• the solvent includes isopropanol, water, or a mixture thereof.
• the present compositions can include one or more surfactants.
• the surfactant or surfactant admixture can include nonionic, semi-polar nonionic, or anionic surface-active agents; or any combination thereof.
• concentration of surfactant or surfactant mixture useful in use solution compositions fall in the range of from about 0.01 to about 30 wt-%, about 1 to about 30 wt-%, about 2 to about 20 wt-%, or about 5 to about 15 wt-%.
• These percentages can refer to percentages of the commercially available surfactant composition, which can contain solvents, dyes, odorants, and the like in addition to the actual surfactant. In this case, the percentage of the actual surfactant chemical can be less than the percentages listed. These percentages can refer to the percentage of the actual surfactant chemical.
• Surfactant can be present at any of these amounts not as part of a range and/or at any of these amounts not modified by about.
• the surfactant includes anionic surfactant, amphoteric surfactant, nonionic surfactant, or mixture thereof.
• the surfactant includes a nonionic surfactant.
• Nonionic surfactants useful in the invention are generally characterized by the presence of an organic hydrophobic group and an organic hydrophilic group and are typically produced by the condensation of an organic aliphatic, alkyl aromatic, fatty alcohol, or polyoxyalkylene hydrophobic compound with a hydrophilic alkaline oxide moiety which in common practice is ethylene oxide or a polyhydration product thereof, polyethylene glycol.
• any hydrophobic compound having a hydroxyl, carboxyl, amino, or amido group with a reactive hydrogen atom can be condensed with ethylene oxide, or its polyhydration adducts, or its mixtures with alkoxylenes such as propylene oxide to form a nonionic surface-active agent.
• the length of the hydrophilic polyoxyalkylene moiety which is condensed with any particular hydrophobic compound can be readily adjusted to yield a water dispersible or water soluble compound having the desired degree of balance between hydrophilic and hydrophobic properties.
• nonionic, semi-polar nonionic, or anionic surface-active agents for use according to the compositions of the invention are more fully disclosed in U.S. Pat. No. 7,341,983.
• the present compositions can include one or more sequestrants.
• Suitable sequestrants include organic chelating compounds that sequester metal ions in solution, particularly transition metal ions.
• Such sequestrants include organic amino- or hydroxy-polyphosphonic acid complexing agents (either in acid or soluble salt forms), carboxylic acids, hydroxycarboxylic acids, or aminocarboxylic acids.
• Chelating agents or sequestrants generally useful in the present compositions include salts or acids of (expressed in acid form) alkyl diamine polyacetic acid-type chelating agents such as ethylenediamine tetraacetic acid (EDTA), hydroxyethylethylethylene diamine triacetic acid (HEDTA), and ethylene triaminepentaacetic acid, phosphonic acid, and phosphonate-type chelating agents among others.
• alkyl diamine polyacetic acid-type chelating agents such as ethylenediamine tetraacetic acid (EDTA), hydroxyethylethylethylene diamine triacetic acid (HEDTA), and ethylene triaminepentaacetic acid, phosphonic acid, and phosphonate-type chelating agents among others.
• Suitable phosphonic acids and phosphonate salts include 1-hydroxy ethylidene-1,1-diphosphonic acid (HEDP); ethylenediamine tetrakis methylenephosphonic acid (EDTMP); diethylenetriamine pentakis methylenephosphonic acid (DTPMP); cyclohexane-1,2-tetramethylene phosphonic acid; amino[tri(methylene phosphonic acid)]; (ethylene diamine[tetra methylene-phosphonic acid)]; 2-phosphene butane-1,2,4-tricarboxylic acid; as well as the alkyl metal salts, ammonium salts, or alkyloyl amine salts, such as mono, di, or tetra-ethanolamine salts.
• HEDP 1-hydroxy ethylidene-1,1-diphosphonic acid
• ETMP ethylenediamine tetrakis methylenephosphonic acid
• DTPMP diethylenetriamine pentakis m
• the present composition can also include any number of adjuvants, including for example, stabilizing agent, wetting agent, thickener, foaming agent, pigment or dye among any number of constituents which can be added to the composition.
• adjuvants can be preformulated with the present composition or added to the system simultaneously, or even after, the addition of the present composition.
• the composition can also contain any number of other constituents as necessitated by the application, which are known and which can facilitate the activity of the present compositions. The types and amounts of such adjuvants and/or constituents will be apparent to those skilled in the art.
• compositions and methods of the invention provide stable antimicrobial compositions that do not experience phase-separation or phase-splitting following application of the composition to a surface.
• phase refers to a homogeneous fluid portion that is present in or that can form in a fluid system.
• phases refers to the presence of more than one phase in a heterogeneous fluid system.
• the compositions (and in some methods of the invention employing such compositions), specifically the amount of antimicrobially-active solvent and a particular cosolvent or surfactant are combined in a ratio sufficient to form a stable, solution of the antimicrobial composition.
• Such compositions have a clear appearance, do not experience phase-separation, and do not undergo phase-splitting.
• compositions according to the invention that retain a clear one-phase mixtures.
• embodiments of the invention may include a slightly cloudy phase dispersion where the solubility limits of the antimicrobial agents are approached. It is to be understood that compositions having saturated antimicrobial agent solubility could be employed if desired. However, preferred embodiments of the invention achieve antimicrobial agent solubility without having to increase the ratio of surfactant to antimicrobial agent.
• compositions of the present invention can be formulated by combining the antimicrobially-active agents, the ethoxylated amine, and any other ingredients, which may be combined to form a concentrate or superconcentrate composition, or which can be diluted at the site of use to form a use solution composition.
• superconcentrates do not include water as an purposefully added raw material (though water can be present in some of the ingredients).
• Superconcentrates can be formulated which are both flowable and stable and can be useful to provide small dispensed volumes or individual dosage packs.
• a solid concentrate composition may be diluted to a use solution prior to application to an object. Primarily for reasons of economics, the concentrate would normally be marketed and an end user would preferably dilute the concentrate with water or an aqueous diluent to a use solution.
• the level of active components in the concentrate composition is dependent on the intended dilution factor and the desired activity of the fatty acid antimicrobial. Generally, a dilution of about 0.1 to about 25 ounces of concentrate composition per gallon of diluent (e.g., water) provides a suitable use composition. Higher use dilutions can be employed if elevated use temperature (greater than 25° C.) or extended exposure time (greater than 30 seconds) can be employed. In the typical use locus, the concentrate is diluted with a major proportion of water using commonly available tap or service water.
• diluent e.g., water
• compositions of the invention can therefore be formulated and sold for use as is, or as solvent concentrates. If desired, such concentrates can be used full-strength as antimicrobial agents. However, the concentrates typically will be diluted with a fluid (e.g., water) that subsequently forms the aqueous use solution. Preferably, the concentrate forms a single phase before such dilution and remains so while stored in the container in which it will be sold.
• a fluid e.g., water
• compositions of the invention When combined with water or other desired diluting fluid at an appropriate dilution level and subjected to mild agitation (e.g., by stirring or pumping the composition), some compositions of the invention will form a pseudo-stable dispersion, and other compositions of the invention will form a clear or quasi-stable solution or dispersion. If a pseudo-stable composition is formed, then the composition preferably remains in the pseudo-stable state for a sufficiently long period so that the composition can be applied to a surface before the onset of phase separation. The pseudo-stable state need only last for a few seconds when suitably rapid application techniques such as spraying are employed, or when agitation during application is employed.
• the pseudo-stable state desirably lasts for at least one minute or more after mixing and while the composition is stored in a suitable vessel, and preferably lasts for five minutes or more after mixing.
• a suitable vessel e.g., a vessel that stores the composition.
• Often normal refilling or replenishment of the applicator e.g., by dipping the applicator in the composition
• the diluting solvent can be used as the diluting solvent, including water in its liquid form; steam; condensed gases and other supercritical fluids (e.g., CO2). Mixtures of diluting solvents can be used if desired.
• the diluting solvent consists essentially of or consists of water in its liquid form. The remainder of this specification will primarily discuss the use of water in its liquid form as the diluting solvent, it being understood that other suitable fluids could be added to or substituted for water in its liquid form if desired.
• the antimicrobial compositions of the invention can be sold in the form of a kit containing the composition together with suitable directions for carrying out the method of the invention. Such directions typically will include recommended dilution ratios, applications, application techniques and safety warnings.
• the methods of cleaning according to the invention comprise, consist of and/or consist essentially of contacting a surface with the antimicrobial composition of the invention.
• the antimicrobial compositions can be applied to microbes or to soiled or cleaned surfaces using a variety of methods.
• the antimicrobial composition can be sprayed or wiped onto a surface; the composition can be caused to flow over the surface, or the surface can be dipped into the composition.
• the compositions can be formulated as liquids, gels, aerosols, waxes, solids, or powders. If steam or another gaseous diluting solvent is employed, then the compositions can be formulated to be applied in a gaseous state.
• the antimicrobial compositions according to the invention can be used for a variety of domestic or industrial applications, e.g., to reduce microbial populations on a surface or object.
• the compositions can be applied in a variety of areas including kitchens, bathrooms, factories, hospitals, dental offices and food plants, and can be applied to a variety of hard or soft surfaces having smooth, irregular or porous topography.
• Suitable hard surfaces include, for example, architectural surfaces (e.g., floors, walls, windows, sinks, tables, counters and signs); eating utensils; hard-surface medical or surgical instruments and devices; and hard-surface packaging.
• Such hard surfaces can be made from a variety of materials comprising, for example, ceramic, metal, glass, wood or hard plastic.
• Suitable soft surfaces include, for example paper; filter media, hospital and surgical linens and garments; soft-surface medical or surgical instruments and devices; and soft-surface packaging.
• Such soft surfaces can be made from a variety of materials comprising, for example, paper, fiber, woven or nonwoven fabric, soft plastics and elastomers.
• the compositions of the invention can also be applied to soft surfaces such as food and skin.
• the compositions are also suitable for application to growing or harvested plant material including leaves, stems, tubers, roots, seeds, and the like.
• the antimicrobial compositions according to the invention can be included in products such as sterilants, sanitizers, disinfectants, soap scum remover, lime remover, delimer, hand wash and sanitizer and other cleaners.
• the compositions have particular utility as a shower cleaner, disinfectant and sanitizer.
• the antimicrobial compositions can also be used in a variety of healthcare and food service applications.
• Embodiments of the present invention are further defined in the following non-limiting Examples. It should be understood that these Examples, while indicating certain embodiments of the invention, are given by way of illustration only. From the above discussion and these Examples, one skilled in the art can ascertain the essential characteristics of this invention, and without departing from the spirit and scope thereof, can make various changes and modifications of the embodiments of the invention to adapt it to various usages and conditions. Thus, various modifications of the embodiments of the invention, in addition to those shown and described herein, will be apparent to those skilled in the art from the foregoing description. Such modifications are also intended to fall within the scope of the appended claims.
• compositions were evaluated for disinfecting efficacy according to the invention.
• the compositions and controls were evaluated for antimicrobial activity against Staphylococcus aureus using the procedure set out in the Germicidal Spray Test (GST) method based on AOAC Official Method 961.02 and applicable sections (Germicidal Spray Products as Disinfectants).
• GST Germicidal Spray Test
• the revised method is available in: Official Methods of Analysis (2009) 18 th Edition, Association of Official Analytical Chemists (AOAC) International, Methods 961.02, Gaithersburg, Md., Chapter 6.
• the methods used a 5 minute contact time against the Staphylococcus aureus at ambient temperature, which according to standard laboratory operating procedure is between 15-30° C.
• Staphylococcus aureus (ATCC No. 6538).
• Citric acid 2-hydroxypropane-1,2,3-tricarboxylic acid, 3-hydroxypentanedioic acid-3 carboxylic acid
• Table 6 demonstrates that the R group on the surfactant plays a large role in the solubilization action of the fatty acid in an aqueous solution, and some R groups more readily solubilize fatty acids than other R groups. Additionally, solubilization of the fatty acid may significantly increase the ratio of surfactant to fatty acid which can negatively affect the activity of the fatty acid.
• This formula was tested for its cleaning ability against soap scum soil and compared to a disinfecting cleanser Formula 6, shown below.
• Black gloss ceramic tiles were sprayed with a hot mixture of synthetic hard water, casein, sodium tallowate, sodium cocoate, vegetable shortening and clay and then baked for 30 minutes at 200° C.
• the tiles were then cooled and the reflectance of the resulting soiled surface was measured with a Gardner Micro-Tri-Gloss reflectance meter.
• the tiles were then sprayed with the product and scrubbed in an apparatus that provided constant normal force onto each tile using a sponge saturated with the product. Each tile was passed a finite number of times with the sponge, rinsed, and reflectance read using the reflectance meter. The before and after reflectance measurements were used along with the measurement taken from an unused tile were compared and the percent change in reflectance was calculated. These percent changes were averaged and compared.
• Formula 1 is considered to be an acceptable cleanser for shower soils.

Landscapes

• Life Sciences & Earth Sciences (AREA)
• Chemical & Material Sciences (AREA)
• Engineering & Computer Science (AREA)
• Wood Science & Technology (AREA)
• Chemical Kinetics & Catalysis (AREA)
• Oil, Petroleum & Natural Gas (AREA)
• Organic Chemistry (AREA)
• Health & Medical Sciences (AREA)
• General Health & Medical Sciences (AREA)
• Agronomy & Crop Science (AREA)
• Pest Control & Pesticides (AREA)
• Plant Pathology (AREA)
• Dentistry (AREA)
• Zoology (AREA)
• Environmental Sciences (AREA)
• Toxicology (AREA)
• Emergency Medicine (AREA)
• Agricultural Chemicals And Associated Chemicals (AREA)
• Detergent Compositions (AREA)

Priority Applications (14)

Applications Claiming Priority (1)

Related Child Applications (1)

Publications (2)

Family

ID=47139746

Family Applications (3)

Family Applications After (2)

Country Status (9)

Families Citing this family (7)

Citations (21)

Family Cites Families (12)

• 2011
  • 2011-05-10 US US13/104,549 patent/US9006286B2/en active Active
• 2012
  • 2012-05-08 CA CA2829778A patent/CA2829778C/en active Active
  • 2012-05-08 JP JP2014509873A patent/JP6092850B2/ja active Active
  • 2012-05-08 AU AU2012252040A patent/AU2012252040B2/en active Active
  • 2012-05-08 BR BR112013025072A patent/BR112013025072B1/pt active IP Right Grant
  • 2012-05-08 CN CN201280020567.4A patent/CN103501606B/zh active Active
  • 2012-05-08 WO PCT/IB2012/052289 patent/WO2012153270A2/en active Application Filing
  • 2012-05-08 EP EP12782925.7A patent/EP2706847A4/en not_active Withdrawn
  • 2012-05-08 MX MX2013012641A patent/MX358770B/es active IP Right Grant
• 2015
  • 2015-03-09 US US14/641,914 patent/US9686981B2/en active Active
• 2017
  • 2017-02-08 JP JP2017021385A patent/JP6717763B2/ja active Active
  • 2017-05-22 US US15/600,956 patent/US9795132B2/en active Active
• 2018
  • 2018-12-10 JP JP2018231079A patent/JP6991959B2/ja active Active
• 2021
  • 2021-09-16 JP JP2021151396A patent/JP2021185211A/ja not_active Withdrawn

Patent Citations (23)

Non-Patent Citations (4)

Also Published As

Similar Documents

Legal Events