US8926582B2 - Sealing cap for a body fluid container and a blood collection device - Google Patents

Sealing cap for a body fluid container and a blood collection device Download PDF

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Publication number
US8926582B2
US8926582B2 US12/617,070 US61707009A US8926582B2 US 8926582 B2 US8926582 B2 US 8926582B2 US 61707009 A US61707009 A US 61707009A US 8926582 B2 US8926582 B2 US 8926582B2
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US
United States
Prior art keywords
cap
body fluid
shielding member
sealing
outer cap
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related, expires
Application number
US12/617,070
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English (en)
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US20100113976A1 (en
Inventor
Hans-Peter Wahl
Rolf Schneebeli
Renato Belz
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Roche Diagnostics AG
Roche Diagnostics Operations Inc
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Roche Diagnostics Operations Inc
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Assigned to ROCHE DIAGNOSTICS AG reassignment ROCHE DIAGNOSTICS AG ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BELZ, RENATO, SCHNEEBELI, ROLF, WAHL, HANS-PETER
Assigned to ROCHE DIAGNOSTICS OPERATIONS, INC. reassignment ROCHE DIAGNOSTICS OPERATIONS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ROCHE DIAGNOSTICS AG
Publication of US20100113976A1 publication Critical patent/US20100113976A1/en
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Publication of US8926582B2 publication Critical patent/US8926582B2/en
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B01L3/50825—Closing or opening means, corks, bungs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0672—Integrated piercing tool

Definitions

  • Embodiments of the invention relate to a sealing cap for a body fluid container and a blood collection device for collecting a blood sample.
  • Containers for body fluid collection and storage are known in many different versions.
  • blood collection devices provided as blood collection tubes.
  • State of the art blood collection tubes have commonly been provided with a thick rubber stopper also referred to as a cap which can be pierced with sharp needles using much force.
  • the collection tubes are used as primary containers in laboratory analyzers.
  • Today, the “usual” practice in laboratories is for the blood collection tubes to be opened before they are placed in an analysis machine in that the cap is removed either manually or using a decapper.
  • Body fluid containers with caps have been found whereby the rubber stopper is pre-pierced with a plastic device creating an opening through which pipetting is possible.
  • Examples include devices disclosed in U.S. Pat. Nos. 5,240,679 and 5,081,872.
  • Other devices and machines are known from U.S. Pat. No. 4,974,457 and WO 90/11752. Both processes mentioned above use disposable plastic parts.
  • Furthermore, there are methods which press a washable hollow needle through the rubber cap which one may then pipette through see U.S. Pat. No. 5,270,211). All of the systems were not able to establish themselves and have disappeared from the market once more.
  • tube containers which do not have the device mentioned above are normally opened (decapped) before they are placed in the analysis equipment and have to receive a new closure (be recapped) prior to storage in a refrigerator. This has to be done for each subsequent analysis.
  • U.S. Pat. No. 6,116,445 discloses a sealing cap for the mouth of a container which facilitates both the sealing of new bottles containing unused contents, and the re-sealing of those bottles already in use so as to preserve their contents.
  • the sealing cap includes an inner cap and an outer cap.
  • the inner cap includes a shielding plate which is fixed on the mouth of a container, and an annular strip which is provided at the lower end of the outer circumferential wall of the inner cap.
  • the outer cap which is fixed on the inner cap, includes a top lid, and a main cap with a guide tube having a lower-end sharp edge located opposite the shielding plate.
  • the lower end of the outer cap engages the outer circumference of the mouth of the container, and at the same time, the lower-end sharp edge of the guide tube pierces the shielding plate. The user then opens the top lid of the outer cap to access the contents of the container.
  • a cap member having an annular wall and a top wall disposed within and connected to the annular wall is known.
  • An arcuate pierce-plow member is disposed on an upper surface of the top wall at a position spaced from the annular wall.
  • the pierce-plow member includes a piercing member disposed adjacent to the substantially flat portion of the plow base member. In an inverted, operative position relative to the container having a pierceable membrane which fluidly seals the mouth, the cap member can be used to pierce the pierceable membrane by rotating the cap member.
  • Embodiments of the invention provide an improved sealing cap for a body fluid container, and a body fluid collection device, which facilitates the handling of a body fluid sample for the user, especially a blood sample.
  • a sealing cap for a body fluid container comprising: an inner cap to be placed on an opening in the body fluid container forming a mouth, the inner cap comprising a shielding member to seal the mouth of the container, an outer cap resting on the inner cap, the outer cap being movable relative to the inner cap, a channel member, wherein by a rotational movement the outer cap is movable between a first position, in which the channel member is located separated from the shielding member, and a second position, in which the channel member is extending through the shielding member, thereby establishing an open state of the shielding member, and wherein the shielding member returns to a closed state when the outer cap is moved back from the second position to the first position.
  • a body fluid collection device for collecting a body fluid sample, e.g. a blood sample, is provided, the device comprising a body fluid container and a sealing cap according to the above described embodiment placed on an opening in the body fluid container forming a mouth.
  • a body fluid collection system for collecting a body fluid sample comprising a body fluid container and a sealing cap according to the above described embodiment placed on an opening in the body fluid container forming a mouth and a pipetting device.
  • FIG. 1 an arrangement with a sealing cap placed on an opening in a body fluid container forming a mouth of the body fluid container, wherein an outer cap is in a starting position
  • FIG. 2 the arrangement with the sealing cap placed on the opening in the body fluid container, wherein the outer cap is still in the starting position, but blood sample has been aspired already,
  • FIG. 3 the arrangement with the sealing cap placed on the opening in the body fluid container, wherein the outer cap is in a lower position
  • FIG. 4 the arrangement with the sealing cap placed on the opening in the body fluid container, wherein the outer cap is in an upper position.
  • a sealing cap for a body fluid container comprising: an inner cap to be placed on an opening in the body fluid container forming a mouth, the inner cap comprising a shielding member to seal the mouth of the container, an outer cap resting on the inner cap, the outer cap being movable relative to the inner cap, a channel member, wherein by a rotational movement the outer cap is movable between a first position, in which the channel member is located separated from the shielding member, and a second position, in which the channel member is extending through the shielding member, thereby establishing an open state of the shielding member, and wherein the shielding member returns to a closed state when the outer cap is moved back from the second position to the first position.
  • the sealing cap for example, may be used for sealing a blood collection tube.
  • An embodiment of the invention comprises the idea of movably mounting the outer cap onto the inner cap in such a way that the outer cap is located in a first position, which could also be referred to as the upper position, in which the channel member forming part of the outer cap is located separated from the shielding member, specifically above this.
  • a first position which could also be referred to as the upper position
  • the channel member forming part of the outer cap is located separated from the shielding member, specifically above this.
  • the outer cap can be moved, by means of a downwards rotational movement, into the second position in which the channel member extends through the shielding member, thus creating an access to the interior of the container through which a body fluid can either flow directly or be extracted using suitable equipment, for example a pipette.
  • suitable equipment for example a pipette.
  • the tip of the latter can be inserted via the body fluid channel in the channel member.
  • the outer cap can be moved back upwards to remove the channel member from the area of the shielding member.
  • the outer cap is guided between the first and second positions in its rotational movement with the help of guiding means.
  • the use of the cap is made easier as through the help of the guiding means, the upward and downward movement of the outer cap is clearly determined. It is not left to the user, as to how much pressure he uses to open the outer cap. Rather, the guiding means define the movement of the outer cap relative to the inner cap in a particular way. The probability of damaging elements of the sealing cap is thus reduced.
  • one embodiment sees a section of the shielding member, previously pushed to one side by the channel member, return to its starting position thus closing the interior of the container once more, in respect to the environment. Even though such a re-sealings usually less tight than the original seal, the container is closed in this way after body fluid has been collected in or extracted from the container and as such a further storage of the body fluid in the container is made possible.
  • the sealing cap or the body fluid collection device can be provided as sterile packaged articles, in particular also as disposable products.
  • the guiding means are configured to guide the outer cap on a helical path in the rotational movement between the first and second position.
  • the configuration of a helical path supports an even and gradual raising and lowering of the outer cap relative to the inner cap, whereby the outer cap slides smoothly into the second position.
  • the channel member is provided with a bottom-end piercing edge, configured to pierce the shielding member when the outer cap is moved from the first position to the second position for the first time by the rotational movement.
  • the shielding member is pierced and cut in such a way that a section of the shielding member can be pushed to one side by the channel member as the channel member passes through the shielding member.
  • the bottom-end piercing edge can be configured in an embodiment such that the cutting or piercing of the shielding member through the downward rotational movement of the outer cap takes place gradually.
  • the bottom-end piercing edge is configured to pierce the shielding member along an annular piercing line.
  • annular piercing line in a preferred embodiment, may be an open circle line.
  • one embodiment sees a section of the shielding member, previously pushed to one side by the channel member, return to its starting position thus closing the interior of the container once more, in respect to the environment. Even though such a re-sealing is usually less tight than the original seal, the container is closed in this way after body fluid has been collected in or extracted from the container and as such a further storage of the body fluid in the container is made possible.
  • restriction means are provided, the restriction means being configured to hold the outer cap in a used first position different from an unused first position when the outer cap is moved from the second position into the first position.
  • the restriction means are provided on facing surfaces of the outer cap and the inner cap.
  • a projection is located which interacts with a recess on the inner cap. The projection slides over the recess in the downwards rotational movement of the outer cap, but jumps into the recess in the upwards rotational movement of the outer cap, thereby providing a locked connection between the inner and outer cap.
  • other engagement mechanism may be provided permitting the downwards rotational movement of the outer cap and securing the outer cap in the used first position.
  • position label means are provided, configured to indicate at least one of the unused first position and the used first position of the outer cap.
  • the latter is characterized by the fact that the cap has already been moved into the second position at least once, and thus an opening exists to the interior of the container for the collection or extraction of body fluid. It is thus, in practice, immediately evident to the user as to whether the container has been used or not.
  • a colored marking as a position label means is preferred.
  • the sealing membrane is in one embodiment made of aluminium foil. This has a coating made of one of polypropylene and polyethylene which is used to further seal the aluminium membrane, for example with suitable conditions in respect of temperature and pressure.
  • a similar sealing is also possible using a sealing membrane made of other materials.
  • the pierceable sealing membrane is configured to avoid penetration of a body fluid including gas. Therefore, in a container sealed by the sealing cap a vacuum can be kept until the pierceable sealing membrane is pierced, for example until the container is filled with a blood sample from a patient in a phlebotomy. In order to fill the container with a blood sample in the scope of a blood test, a cannula is inserted through the sealing membrane and further through the shielding member.
  • the outer cap is provided as a molded member made of a plastic material.
  • the inner cap is made of an elastic material such as a thermoplastic elastomer or rubber.
  • guiding means are provided, configured to guide the outer cap relative to the inner cap in the rotational movement between the first and second position.
  • the guiding means comprise threads configured to provide a threaded connection between the outer cap and the inner cap.
  • the channel member is provided with a passage for a pipetting device.
  • the passage is provided with a diameter in the range from about 3 mm to about 11 mm.
  • the inner cap is provided as a stopper member, the stopper member comprising an inner circumferential wall and an outer circumferential wall.
  • a body fluid collection device for collecting a body fluid sample, e.g. a blood sample, is provided, the device comprising a body fluid container and a sealing cap according to any of the above described embodiments placed on an opening in the body fluid container forming a mouth.
  • a body fluid collection system for collecting a body fluid sample comprising a body fluid container and a sealing cap according to any of the above described embodiments placed on an opening in the body fluid container forming a mouth and a pipetting device.
  • the pipetting device for example, is provided as a pipetting needle.
  • FIGS. 1 to 4 show a sealing cap 1 , with which a mouth 2 of a container 3 is closed.
  • the container 3 is, for example, a tube for the collection of an extracted bodily fluid, in particular a blood sample, but can be used also for storage of other body fluids.
  • the sealing cap 1 comprises an inner cap 4 and an outer cap 5 , which rests on the inner cap 4 .
  • the inner cap 4 is mounted on a wall 6 of the container 3 .
  • the mouth 2 of the container 3 is sealed body fluid-tight with the help of a shielding member 7 which forms part of the inner cap 4 .
  • Such a starting position is shown in FIG. 1 .
  • the shielding member 7 is also covered with a sealing membrane 8 which supports the body fluid-tight seal of the container 3 , especially a gas-tight seal.
  • the preferred form of the sealing membrane 8 is a coated foil, such as aluminum foil, which is sealed onto the shielding member 7 .
  • a channel member or piercing member 9 is located above the shielding member 7 and the sealing membrane 8 .
  • an opening 10 is formed in the outer cap 5 through which a channel or passage 11 runs which is configured to receive a pipetting device (not shown).
  • FIG. 2 shows the situation after blood sample has been collected using the method described above as the sealing membrane is now, in contrast to FIG. 1 , pushed downwards at least in the centre due to the prior piercing or cutting.
  • the temporary opening in the shielding member 7 formed through the piercing with the cannula is automatically re-sealed due to the material of the shielding member 7 , for example rubber or a thermo-plastic elastomer.
  • FIG. 3 shows the outer cap 5 in a second position which is characterized by the fact that the channel member 9 extends through the shielding member 7 .
  • access is gained to the interior of the container 3 through the channel 11 in the channel member 9 , for example using a syringe or the tip of a pipette in order to remove part of the blood sample.
  • the moving of the outer cap 5 into the second position as shown in FIG. 3 is achieved by rotating the outer cap 5 relative to the inner cap 4 .
  • This rotational movement of the outer cap 5 leads to a guided downwards movement of the outer cap 5 whereby a piercing or cutting edge 12 pierces or cuts through the shielding member 7 which subsequently leads to a section 13 of the shielding member 7 being pushed to one side by the channel member 9 as shown in FIG. 3 .
  • the piercing or cutting edge 12 cuts the shielding member 7 gradually, along an open annular piercing line, without completely separating the section 13 .
  • the outer cap 5 can be moved back upwards again with a screw or rotational movement in the opposite direction, as shown in FIG. 4 .
  • the channel member 9 is located above and separated from the shielding member 7 once more.
  • the outer cap 5 is not returned to the starting position shown in FIG. 1 .
  • restriction means which may be provided as a locking connection secure the outer cap 5 in the position shown in FIG. 4 , but permit the rotational movement. Whether or not the outer cap 5 is in the starting position shown in FIG. 1 or in the position in FIG.
  • the outer cap 5 could have an opening which overlaps with a colored marking on the inner cap 4 whereby a different color is visible to the user through the opening depending on the position of the outer cap 5 .
  • the section 13 of the shielding member 7 shown pushed to one side in FIG. 3 , has returned to its starting position so that the shielding member 7 seal the container 3 once more. Any remaining blood, or other body fluid, can thus be stored further, for example in a refrigerator.
  • the outer cap 5 can be moved into the position shown in FIG. 3 several times in order to remove or add body fluid samples. Each time the outer cap 5 is subsequently returned to the position in FIG. 4 through the rotational movement, the container 3 is re-closed with the help of the shielding member 7 .
  • the inner cap 4 has thicker sections 16 which comprise a possible embodiment of grip elements which facilitate the attachment and removal of the sealing cap 1 .

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Closures For Containers (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Sampling And Sample Adjustment (AREA)
US12/617,070 2007-05-25 2009-11-12 Sealing cap for a body fluid container and a blood collection device Expired - Fee Related US8926582B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP07010483 2007-05-25
EP07010483A EP1995182A1 (en) 2007-05-25 2007-05-25 A sealing cap for a fluid container and a blood collection device
EP0701043.1 2007-05-25
PCT/EP2008/004080 WO2008145294A1 (en) 2007-05-25 2008-05-21 A sealing cap for a body fluid container and a blood collection device

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/004080 Continuation WO2008145294A1 (en) 2007-05-25 2008-05-21 A sealing cap for a body fluid container and a blood collection device

Publications (2)

Publication Number Publication Date
US20100113976A1 US20100113976A1 (en) 2010-05-06
US8926582B2 true US8926582B2 (en) 2015-01-06

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US12/617,070 Expired - Fee Related US8926582B2 (en) 2007-05-25 2009-11-12 Sealing cap for a body fluid container and a blood collection device

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US (1) US8926582B2 (enExample)
EP (2) EP1995182A1 (enExample)
JP (1) JP5165051B2 (enExample)
CN (1) CN101678931B (enExample)
AT (1) ATE540875T1 (enExample)
CA (1) CA2679654C (enExample)
WO (1) WO2008145294A1 (enExample)

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JP2019537483A (ja) * 2016-11-14 2019-12-26 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッドＳｉｅｍｅｎｓ Ｈｅａｌｔｈｃａｒｅ Ｄｉａｇｎｏｓｔｉｃｓ Ｉｎｃ． 一体化された吸収材料を有する採血装置
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