US8419075B2 - Tubes and their manufacture - Google Patents
Tubes and their manufacture Download PDFInfo
- Publication number
- US8419075B2 US8419075B2 US12/734,962 US73496208A US8419075B2 US 8419075 B2 US8419075 B2 US 8419075B2 US 73496208 A US73496208 A US 73496208A US 8419075 B2 US8419075 B2 US 8419075B2
- Authority
- US
- United States
- Prior art keywords
- shaft
- opening
- tube
- component
- components
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active, expires
Links
- 238000004519 manufacturing process Methods 0.000 title claims description 7
- 239000000463 material Substances 0.000 claims abstract description 34
- 239000012815 thermoplastic material Substances 0.000 claims abstract description 9
- 229920000295 expanded polytetrafluoroethylene Polymers 0.000 claims abstract 2
- 238000000034 method Methods 0.000 claims description 12
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 7
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 7
- 238000000465 moulding Methods 0.000 claims description 4
- 238000004080 punching Methods 0.000 abstract 1
- 229920001684 low density polyethylene Polymers 0.000 description 4
- 239000004702 low-density polyethylene Substances 0.000 description 4
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000009969 flowable effect Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 229920000098 polyolefin Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/04—Tracheal tubes
- A61M16/0465—Tracheostomy tubes; Devices for performing a tracheostomy; Accessories therefor, e.g. masks, filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/04—Tracheal tubes
- A61M16/0402—Special features for tracheal tubes not otherwise provided for
- A61M16/0427—Special features for tracheal tubes not otherwise provided for with removable and re-insertable liner tubes, e.g. for cleaning
Definitions
- This invention relates to tubes of the kind having a shaft and an end fitting attached with the shaft at one end.
- tracheostomy tube assemblies commonly include an outer tube and an inner tube or cannula that is a removable fit within the outer tube.
- the inner tube can be removed and replaced periodically to ensure that the passage through the assembly does not become blocked by secretions. This avoids the need frequently to remove the outer tube.
- the inner tube presents various problems because it must be thin walled and a close fit within the outer tube so as to limit the resistance to flow of gas along the assembly. It must, however, also be sufficiently stiff to be inserted in the outer tube without buckling or kinking.
- a particularly suitable material for the inner cannula is PTFE or expanded PTFE (ePTFE). The use of such a material in an inner cannula is described in WO94/01156 and in WO2004/101048.
- the Flextra tube sold by Tyco Healthcare is made of ePTFE. Whilst such a material has various advantages, the material makes it difficult to attach a hub or end fitting to the machine end of the shaft of the cannula securely in a reliable and low cost manner. There are also other tubes where it can be difficult to attach an end fitting.
- a tube of the above-specified kind characterised in that the shaft has an opening formed through the wall of the shaft close to the one end, that a cylindrical inner component extends over the inside of the opening within the one end, that a separate outer component extends over the outside of the opening on the outside of the shaft, and that material extends between the outer and inner components through the opening so that the outer component is bonded to the inner component via the opening.
- the material extending between the outer and inner components is preferably material of the outer or inner component flowed through the opening.
- the outer component is preferably overmoulded onto the one end.
- the inner and outer components are preferably of a thermoplastic material.
- the shaft is preferably of a PTFE material, such as ePTFE.
- the shaft may be swaged to form an expanded region at the one end in which the cylindrical inner component is inserted.
- the tube may be an inner tube of a tracheostomy tube assembly.
- a method of manufacture of a tube including the steps of providing a tubular shaft, forming an opening through the wall of the shaft close to one end, providing separate inner and outer tubular components extending over the opening respectively on the inside and outside of the shaft, and causing material to extend through the opening between the inner and outer tubular components to bond them with one another.
- a method of manufacture of a tube including the steps of providing a tubular shaft, forming an opening through the wall of the shaft close to one end, inserting an tubular inner component in the one end of the shaft to cover the inner end of the opening, and moulding over the outside of the one end of the shaft a tubular outer component so that the material of the outer part flows through the opening and bonds with the inner component.
- the material of the shaft is preferably different from that of the inner and outer parts.
- the shaft is preferably of a PTFE material and the inner and outer tubular parts are preferably of the same thermoplastic material.
- FIG. 1 shows the assembly schematically
- FIG. 2 is a perspective view of the inner cannula
- FIG. 3 is a cross-sectional side elevation view of the machine end of the inner cannula to an enlarged scale
- FIG. 4 is a side elevation view of the shaft of the inner cannula before swaging and attachment of the end fitting;
- FIG. 5 is a perspective view of an insert used to form the end fitting of the inner cannula.
- FIG. 6 is a partly cut-away perspective view of the end fitting on the machine end of the inner cannula.
- the tracheostomy tube assembly comprises an outer tube 1 and an inner tube or cannula 3 , which is removable from the outer tube so that it can be periodically replaced in the usual way.
- the outer tube 1 is entirely conventional having a shaft 10 with straight forward or patient end section 11 and rear or machine end section 12 joined by a right-angle bend section 13 .
- Alternative outer tubes could be smoothly curved along their entire length or could be highly flexible and reinforced with a natural straight shape.
- a sealing cuff 14 embraces the shaft 10 close to its patient end 15 ; this can be inflated for sealing, or deflated for insertion and removal, via an inflation line 16 and a combined inflation indicator balloon and coupling 17 .
- the outer tube 1 has a flange 19 to which a tape (not shown) can be attached for securing the assembly around the neck of the patient.
- a hub 20 projects from the machine side of the flange 19 by which gas connection can be made to the tube 1 .
- the tube 1 In use, the tube 1 extends through a surgically-made tracheostomy opening in the neck, with the patient end 15 of the tube 1 located in the trachea.
- the cuff 14 is inflated to form a seal between the outside of the tube and the tracheal wall so that gas flow is confined along the bore of the tube.
- the machine end 18 of the tube 1 extends externally of the tracheostomy.
- the inner tube or cannula 3 comprises a shaft 30 and a machine end fitting 31 .
- the inner cannula 3 is about 194 mm long and its shaft 30 has an internal diameter of about 8 mm with an external diameter of about 9 mm along the major part of its length.
- the cannula 3 extends as a close sliding fit within the bore of the outer tube 1 with the patient end 32 of the cannula extending substantially level with the patient end 15 of the outer tube and with its end fitting 31 locating in the hub 20 of the outer tube.
- the shaft 30 is of ePTFE and is made by cutting from a length of extruded stock tubing.
- the nature of the shaft 30 is that it can flex readily to conform to the shape of the outer tube 1 without kinking as it is inserted.
- the shaft material has a very low coefficient of friction so that it can be inserted readily into the outer tube 1 as a close sliding fit without excessive axial compression forces being produced of a kind that could cause the shaft 30 to buckle.
- Two circular openings or holes 33 with a diameter of about 3 mm are punched through the wall of the shaft 30 diametrically opposite one another at a location spaced 5 mm from the machine end 34 of the shaft. The purpose of these openings 33 will become apparent later.
- the rear or machine end of the shaft 30 including the holes 33 is then swaged outwardly to form an expanded region 30 ′.
- the machine end fitting 31 on the inner cannula 3 is made of a material different from that of the shaft 30 and, in particular, it is made of a flowable thermoplastic material such as low density polyethylene (LDPE), which has a low melt temperature. Other thermoplastic materials could be used such as a polyolefin or polyurethane.
- LDPE low density polyethylene
- Other thermoplastic materials could be used such as a polyolefin or polyurethane.
- the end fitting 31 has a stepped profile to conform to the inner surface of the hub 20 on the outer tube 1 within which it is fitted.
- An enlarged flange 35 projects outwardly towards the rear end of the fitting 31 , its size being selected so that it abuts the rear end of the hub 20 and limits the extent of insertion of the inner cannula 3 .
- the end fitting 31 is also provided with a hinged ring-pull feature 36 of the kind described in U.S. Pat. No. 4,817,598 to facilitate removal of the inner cannula.
- the LDPE used to make the fitting 41 is particularly suitable for forming the flexible hinge in the ring-pull feature 36 .
- the machine end fitting 31 is formed by a preformed insert attached with an overmoulded outer component.
- the insert or inner component 40 is shown in FIG. 5 and is a preformed cylindrical component moulded from LDPE and is about 12.5 mm long, which is approximately equal to the length of the expanded region 30 ′ of the shaft 30 .
- the insert 40 has a circular section with a smooth, uninterrupted inner surface or bore 41 and tapers at an angle of about 2.5° to an enlarged diameter rearwardly.
- the insert 40 is also tapered and is formed with an annular, rearwardly inclined tooth or barb 42 close to its forward end 43 .
- the insert 40 has an externally-projecting flange 45 .
- the external diameter of the insert 40 at its forward end 43 is equal to the internal diameter of the swaged region 30 ′ of the shaft 30 so that the insert can be pushed into the end of the shaft.
- the internal diameter of the insert 40 is the same as that of the main part of the shaft 30 so that the bore through the insert and shaft is smooth and continuous. The insert 40 is pushed fully into the expanded region 30 ′ until the flange 45 abuts the rear end 34 of the shaft 30 .
- the insert 40 When fully inserted the insert 40 extends over the inner surface of the two openings 33 in the shaft 30 .
- the barb 42 improves retention of the insert 40 in the shaft.
- the insert could have more than one barb and the barb or barbs need not be annular but could be separate barbs spaced around the insert.
- the end fitting 31 is completed by inserting the rear end 34 of the shaft 30 and insert 40 into a mould (not shown) and overmoulding an outer tubular member or component 46 onto the shaft 30 as most clearly shown in FIG. 6 .
- This outer part 46 extends from a location just rearwardly of the barb 42 on the insert 40 and forwardly of the openings 33 in the shaft 30 so that the outer end of these are both covered by the outer part.
- the outer component 46 defines the external shape of the end fitting 31 with its ring-pull feature 36 .
- the outer component 46 is moulded over the outer curved surface and the rear end surface of the flange 45 and thereby bonds with the flange and traps it between the outer part and the shaft 30 .
- Material 47 of the overmoulded outer part 46 also flows into the two openings 33 in the shaft 30 during the moulding operation and bonds with the outer surface of the insert 40 exposed by the openings. It will be appreciated that, when the material 47 of the overmoulded outer component 46 has hardened, the outer component will be intimately and securely bonded with the insert 40 both at the flange 45 and through the openings 33 . This securely locks the shaft 30 with the end fitting 31 without the need for any bond between the two different materials. Because the inner cannula is preformed, it helps support the shaft during this overmoulding operation.
- the invention is not confined to inner cannulae but could be used with other tubes for medical or non-medical applications and is especially advantageous where the tube shaft is of a material that does not bond readily with the end fitting.
- the tube shaft is of a material that does not bond readily with the end fitting.
- the invention is applicable with only one opening or with more than two.
- the end fitting could be provided by a preformed outer component and by moulding the inner component.
- the end fitting could be provided by preformed inner and outer components and an adhesive added to the openings to bond the two components with one another.
Landscapes
- Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0800112.5A GB0800112D0 (en) | 2008-01-04 | 2008-01-04 | Tubes and their manufacture |
GB0800112.5 | 2008-01-04 | ||
PCT/GB2008/004077 WO2009087347A1 (fr) | 2008-01-04 | 2008-12-11 | Tubes et leur fabrication |
Publications (2)
Publication Number | Publication Date |
---|---|
US20100244432A1 US20100244432A1 (en) | 2010-09-30 |
US8419075B2 true US8419075B2 (en) | 2013-04-16 |
Family
ID=39111126
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/734,962 Active 2029-11-05 US8419075B2 (en) | 2008-01-04 | 2008-11-12 | Tubes and their manufacture |
Country Status (10)
Country | Link |
---|---|
US (1) | US8419075B2 (fr) |
EP (1) | EP2224985B1 (fr) |
JP (1) | JP5612481B2 (fr) |
CN (1) | CN101918063B (fr) |
AU (1) | AU2008346281B2 (fr) |
BR (1) | BRPI0821472A2 (fr) |
CA (1) | CA2706187A1 (fr) |
GB (1) | GB0800112D0 (fr) |
MX (1) | MX2010005689A (fr) |
WO (1) | WO2009087347A1 (fr) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20150252933A1 (en) * | 2014-03-10 | 2015-09-10 | Saint-Gobain Performance Plastics France | Pipe coupling |
WO2017046550A1 (fr) | 2015-09-15 | 2017-03-23 | Smiths Medical International Limited | Tubes et leur fabrication |
WO2017068314A1 (fr) | 2015-10-24 | 2017-04-27 | Smiths Medical International Limited | Tubes médico-chirurgicaux et leur fabrication |
WO2019069040A1 (fr) | 2017-10-07 | 2019-04-11 | Smiths Medical International Limited | Tubes et leur fabrication |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20110290254A1 (en) * | 2010-05-27 | 2011-12-01 | Nellcor Puritan Bennett Llc | Tracheal tube with connector insert |
US9136680B2 (en) * | 2010-07-26 | 2015-09-15 | Mikeal Roberts | Protective fitting |
US8905030B2 (en) | 2011-03-31 | 2014-12-09 | Covidien Lp | Tracheal tube with connector insert |
US8910669B2 (en) | 2012-02-23 | 2014-12-16 | Ticona Llc | Insert for pipe assembly and method for forming pipe assembly |
US9010326B2 (en) | 2012-08-02 | 2015-04-21 | Covidien Lp | Compressible connector for an inner cannula |
US9463968B2 (en) | 2012-10-17 | 2016-10-11 | Brewnique LLC | Faucet assembly |
US9265906B2 (en) | 2013-02-25 | 2016-02-23 | Covidien Lp | Compressible cannula connector with release grip |
GB201303553D0 (en) | 2013-02-28 | 2013-04-10 | Smiths Medical Int Ltd | Tracheostomy tube assemblies and inner cannulae |
GB201303554D0 (en) | 2013-02-28 | 2013-04-10 | Smiths Medical Int Ltd | Tracheostomy tube assemblies and inner cannulae |
GB201319087D0 (en) * | 2013-10-29 | 2013-12-11 | Indian Ocean Medical Inc | Artificial airway device |
US9907921B2 (en) | 2013-11-14 | 2018-03-06 | Covidien Lp | Tracheostomy tube with inner cannula |
GB201404219D0 (en) * | 2014-03-08 | 2014-04-23 | Smiths Medical Int Ltd | Tracheostomy tube assemblies, inner cannulae and methods of manufacture |
WO2015139114A1 (fr) * | 2014-03-17 | 2015-09-24 | Omachron Intellectual Property Inc. | Compensateur de dilatation et procédés de fabrication d'un compensateur de dilatation |
CA2846801C (fr) | 2014-03-17 | 2017-04-25 | G.B.D. Corp. | Compensateur de dilatation dote de connecteurs |
GB201407573D0 (en) | 2014-04-30 | 2014-06-11 | Smiths Medical Int Ltd | Tubes and their manuacture |
CA2855326A1 (fr) | 2014-06-26 | 2015-12-26 | G.B.D. Corp. | Methodes d'installation de compensateur de dilatation |
GB201506545D0 (en) * | 2015-04-16 | 2015-06-03 | Smiths Medical Int Ltd | Tracheostomy tube assemblies and inner cannulae |
GB201507548D0 (en) * | 2015-04-29 | 2015-06-17 | Smiths Medical Int Ltd | Medico-surgical tube assemblies |
GB201510231D0 (en) | 2015-06-11 | 2015-07-29 | Smiths Medical Int Ltd | Tracheostomy tube assemblies and inner cannulae |
GB201510230D0 (en) | 2015-06-11 | 2015-07-29 | Smiths Medical Int Ltd | Tracheostomy tube assemblie and inner cannulae |
GB201512674D0 (en) | 2015-07-15 | 2015-08-26 | Smiths Medical Int Ltd | Tracheostomy tube assemblies and inner cannulae |
GB201515450D0 (en) | 2015-08-29 | 2015-10-14 | Smiths Medical Int Ltd | Tracheostomy tube assemblies and inner cannulae |
USD783786S1 (en) | 2015-11-02 | 2017-04-11 | Brewnique LLC | Faucet tube |
CN109543229B (zh) * | 2018-10-24 | 2022-09-02 | 吉林大学 | 变厚度十二直角截面薄壁梁压溃特性分析方法 |
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US46395A (en) * | 1865-02-14 | Improvement in brazing brass screws to iron pipes | ||
US429947A (en) * | 1890-06-10 | Half to john | ||
US539112A (en) * | 1895-05-14 | Pipe-coupling | ||
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CN2253210Y (zh) * | 1996-03-29 | 1997-04-30 | 王文清 | 套管式多功能气管导管 |
US7681576B2 (en) * | 2003-05-06 | 2010-03-23 | Mallinckrodt Inc. | Multiple cannula systems and methods |
CN200948285Y (zh) * | 2006-08-22 | 2007-09-19 | 张春炳 | 多功能气管套管 |
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2008
- 2008-01-04 GB GBGB0800112.5A patent/GB0800112D0/en not_active Ceased
- 2008-11-12 US US12/734,962 patent/US8419075B2/en active Active
- 2008-12-11 WO PCT/GB2008/004077 patent/WO2009087347A1/fr active Application Filing
- 2008-12-11 MX MX2010005689A patent/MX2010005689A/es unknown
- 2008-12-11 BR BRPI0821472-7A patent/BRPI0821472A2/pt not_active IP Right Cessation
- 2008-12-11 CA CA2706187A patent/CA2706187A1/fr not_active Abandoned
- 2008-12-11 AU AU2008346281A patent/AU2008346281B2/en not_active Ceased
- 2008-12-11 CN CN200880124008.1A patent/CN101918063B/zh not_active Expired - Fee Related
- 2008-12-11 EP EP08870172A patent/EP2224985B1/fr active Active
- 2008-12-11 JP JP2010541093A patent/JP5612481B2/ja not_active Expired - Fee Related
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US46395A (en) * | 1865-02-14 | Improvement in brazing brass screws to iron pipes | ||
US429947A (en) * | 1890-06-10 | Half to john | ||
US539112A (en) * | 1895-05-14 | Pipe-coupling | ||
US2211776A (en) * | 1937-08-02 | 1940-08-20 | George W Haury | Resilient coupling for tubing and method for making the same |
US2246404A (en) * | 1939-10-20 | 1941-06-17 | Oscar A Ross | Vacuum cleaner attachment |
US2845657A (en) * | 1953-05-13 | 1958-08-05 | Gen Motors Corp | Molding apparatus and method |
US3400951A (en) * | 1965-02-17 | 1968-09-10 | Irvin D. Jacobson | Dip tube hanger |
US3936078A (en) * | 1974-04-17 | 1976-02-03 | Rene Wallyn | Damping device for coupling together piping elements |
JPS5224318A (en) * | 1975-08-20 | 1977-02-23 | Aron Kasei Co Ltd | A faucet for a t.s. joint and its manufacturing method |
US4552384A (en) * | 1978-10-18 | 1985-11-12 | Battenfeld Maschinenfabriken Gmbh | Molded-joint assembly |
US4682797A (en) * | 1985-06-29 | 1987-07-28 | Friedrichsfeld Gmbh Keramik-Und Kunststoffwerke | Connecting arrangement with a threaded sleeve |
US5316350A (en) | 1991-04-26 | 1994-05-31 | Dragerwerk Aktiengesellschaft | Coupling device for a tube system |
US5406983A (en) * | 1992-11-13 | 1995-04-18 | Mobil Oil Corporation | Corrosion-resistant composite couplings and tubular connections |
US5333650A (en) * | 1993-03-17 | 1994-08-02 | Flexon Industries Corporation | Hose coupling with a stiffening sleeve |
US6070915A (en) * | 1998-05-08 | 2000-06-06 | Luo; Chung-I | Coupling device for tube |
US6099975A (en) * | 1998-10-14 | 2000-08-08 | Peterson; Willis H. | Molded nipple connection system |
US6808209B2 (en) * | 2001-06-26 | 2004-10-26 | Nifco Inc. | Attachment to be attached to fuel tank |
US7988204B2 (en) * | 2003-08-21 | 2011-08-02 | Charlotte Pipe And Foundry Company | Pipe fitting for connecting between a metal piece of plumbing and a polymer piece of plumbing |
US8172275B2 (en) * | 2003-08-21 | 2012-05-08 | Charlotte Pipe And Foundry Company | Composite polymeric transition pipe fitting for joining polymeric and metallic pipes |
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20150252933A1 (en) * | 2014-03-10 | 2015-09-10 | Saint-Gobain Performance Plastics France | Pipe coupling |
US9488303B2 (en) * | 2014-03-10 | 2016-11-08 | Saint-Gobain Performance Plastics Corporation | Pipe coupling |
WO2017046550A1 (fr) | 2015-09-15 | 2017-03-23 | Smiths Medical International Limited | Tubes et leur fabrication |
WO2017068314A1 (fr) | 2015-10-24 | 2017-04-27 | Smiths Medical International Limited | Tubes médico-chirurgicaux et leur fabrication |
WO2019069040A1 (fr) | 2017-10-07 | 2019-04-11 | Smiths Medical International Limited | Tubes et leur fabrication |
Also Published As
Publication number | Publication date |
---|---|
WO2009087347A1 (fr) | 2009-07-16 |
BRPI0821472A2 (pt) | 2015-06-16 |
CN101918063A (zh) | 2010-12-15 |
CN101918063B (zh) | 2012-11-21 |
EP2224985A1 (fr) | 2010-09-08 |
JP2011508644A (ja) | 2011-03-17 |
US20100244432A1 (en) | 2010-09-30 |
CA2706187A1 (fr) | 2009-07-16 |
GB0800112D0 (en) | 2008-02-13 |
AU2008346281A1 (en) | 2009-07-16 |
MX2010005689A (es) | 2010-09-27 |
EP2224985B1 (fr) | 2012-08-01 |
AU2008346281B2 (en) | 2014-03-06 |
JP5612481B2 (ja) | 2014-10-22 |
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