US7182228B2 - Cartridge with connection for a pump-drive and fluid handling system - Google Patents

Cartridge with connection for a pump-drive and fluid handling system Download PDF

Info

Publication number
US7182228B2
US7182228B2 US10/672,219 US67221903A US7182228B2 US 7182228 B2 US7182228 B2 US 7182228B2 US 67221903 A US67221903 A US 67221903A US 7182228 B2 US7182228 B2 US 7182228B2
Authority
US
United States
Prior art keywords
longitudinal section
connection element
actuator
tank
connection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related, expires
Application number
US10/672,219
Other languages
English (en)
Other versions
US20040124214A1 (en
Inventor
Andreas Krueger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens AG
Directif GmbH
Original Assignee
Directif GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Directif GmbH filed Critical Directif GmbH
Assigned to SIEMENS AKTIENGESELLSCHAFT reassignment SIEMENS AKTIENGESELLSCHAFT ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: KRUEGER, ANDREAS
Publication of US20040124214A1 publication Critical patent/US20040124214A1/en
Assigned to DIRECTIF GMBH, SIEMENS AKTIENGESELLSCHAFT reassignment DIRECTIF GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: SIEMENS AKTIENGESELLSCHAFT
Application granted granted Critical
Publication of US7182228B2 publication Critical patent/US7182228B2/en
Expired - Fee Related legal-status Critical Current
Adjusted expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/10—Devices for withdrawing samples in the liquid or fluent state
    • G01N1/14—Suction devices, e.g. pumps; Ejector devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/04—Exchange or ejection of cartridges, containers or reservoirs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/141—Preventing contamination, tampering
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof

Definitions

  • the present invention concerns a cartridge for handling and transport of a fluid (liquid or gaseous substance), as well as a system for handling a fluid using such a cartridge.
  • the invention concerns in particular a cartridge for handling a medical fluid as well as an analysis device to examine medically relevant properties of a fluid using such a cartridge.
  • a number of examinations are implemented on liquids or gases (fluids), for example blood, urine, saliva, gastric juices, or respiratory air.
  • the examinations can provide the analysis of widely varied parameters of chemical, microbiological, or physical properties.
  • microbiological analysis methods play an increasingly larger role. These frequently have as a goal the electrochemical detection of nucleotide sequences that can indicate genetic aberrations or the existence of pathogenic bacteria or viruses.
  • the detection of nucleotide bases is normally based on a two-stage method, in the first step of which DNA fragments present in the fluid are reproduced multiple times, in order to increase the probability of detection for the actual detection in the second step. Since genetic contamination is also thereby multiplied, this method poses particularly high demands on the cleanliness of the procedural apparatuses.
  • An object of the present invention is to enable the handling of a fluid in cartridges with only a minimal handling effort, but which is sufficiently economically feasible for single (one-time) use products.
  • the cartridge has a tank shaped as a cylinder with an opening to admit and discharge the fluid, as well as a piston that can be moved forward and/or back in the tank in order to pump the fluid in or out through the opening.
  • the piston has a connection element that can be connected with an actuator in order to move the piston forward and/or back.
  • the connection element and the actuator are adapted to one another such that the connection is automatically closed in a first longitudinal section of the tank, given movement of the piston in the longitudinal direction, and is automatically released again given movement in the opposite direction.
  • the connection remains closed in a second longitudinal section of the tank, given movement of the piston into this second longitudinal section.
  • the invention is based on the use of a cartridge that possesses an integral pump system actuated from outside the cartridge to handle fluids.
  • cartridge means a substance container, adapted to particular requirements, that can have thick or thin walls and may have additional features such as integrated heating or cooling systems or the like.
  • the pump system for example a pump piston, can automatically couple and decouple with the pump actuation of a handling system by means of a positive-fit connection. It is thus not necessary to use additional pump systems such as, for example, injectors or piston pumps for handling. In the handling, additional effort for the coupling and decoupling of the cartridge to the handling system thus can be avoided.
  • the pump system in addition to the cartridge, is also manufacturable from inexpensive components such as molded plastic components.
  • the cartridge thus can be manufactured at a low cost and made available in large quantities.
  • the ability to economically manufacture large quantities is of particular advantage in the use of the cartridge for central, serial laboratory examination of large numbers of probes that must be spatially separately removed on site.
  • the low-cost manufacturability of the cartridges in large numbers makes them economically useable in addition as a one-time product. Additionally, the logistic effort for frequent, spatially separate use can thereby be reduced. Time and expense for the complex cleaning of the cartridges is not needed with regard to analysis methods that have particular requirements as to purity.
  • the production outlay is minimized by designing the automatically producible connection between integral pump system of the cartridge and the pump actuator of the analysis device or dosing device without complicated, fine mechanical working parts, and solely on the basis of an elastic, formed component.
  • the elastic, formed component is fashioned such that has catches or jaw elements that, upon infeed of the integral pump system via the external pump actuator, enters into a positive-fit connection by means of a longitudinal motion.
  • the positive-fit connection allows the integral pump system also to be retracted by the pump actuator, with the positive-fit connection becoming detached when, upon the retraction, the integral pump system once again reaches its starting point.
  • a further advantage is that the integrated pump system is implemented as a one-time use system. It can, if necessary, undergo the same cleaning steps as the entire cartridge, and therefore fulfills the same requirements for purity. In the one-time use, it must likewise not be elaborately cleaned for reuse. Moreover, the purity of the fluids to be handled also benefits from the integration of the pump system, because the transfer via and the contact with additional pump systems, for example injectors, is avoided.
  • a further object of the invention is to provide a system that enables the handling of fluids by means of a low-cost producible cartridge that can be automatically coupled and again decoupled with the system via a positive-fit connection. Due to the automatic coupling, the number of individual handling steps is reduced. The low-cost manufacturability of the cartridges enables the economic application in large quantities and use as a one-time product.
  • FIG. 1 shows a cartridge and analysis device or dosing device with a disconnected pump actuation in accordance with the invention.
  • FIG. 2 shows cartridge and analysis device or dosing device with a connected pump actuation in accordance with the invention.
  • FIG. 3 is an enlarged depiction of an embodiment of the connection components.
  • FIG. 4 is an enlarged depiction of a further embodiment of the connection components.
  • FIG. 1 shows a system according to the invention with a cartridge 3 and a dosing device or analysis device 9 .
  • the cartridge 3 can be formed of plastic, metal or another suitable material, dependent on the liquid or the gas to be handled.
  • the cartridge 3 has a tank 2 shaped as a cylinder, the cross-section of which can be arbitrarily fashioned, but the simpler shapes are semi-circular and circular.
  • Located in the tank 2 in FIG. 1 is a fluid 1 that is pumped in via an opening 4 lying the front wall of the tank 2 .
  • a piston 5 is arranged in the tank 2 that can be moved forward and back in order to pump the fluid in or out. So that the pump 5 can form a sealed connection with the inner wall of the tank 2 , the surfaces on both sides have a suitable surface finish.
  • at least one of the two sealing components can be made of elastic material.
  • seal rings can be arranged on the piston 5 (which are not shown in FIG. 1 ).
  • the piston 5 has a connection element 7 that is shown in FIG. 1 as a separate component mechanically connected with the piston 5 .
  • a connection element 7 that is shown in FIG. 1 as a separate component mechanically connected with the piston 5 .
  • Non-integrated components may be necessary in the event that the fluid 1 contacting the piston 5 has properties that require the use of material for the piston 5 that is incompatible with the mechanical requirements for the material of the connection element 7 .
  • the connection element 7 could be made of elastic plastic, however the fluid 1 may exhibit aggressive characteristics with regard to the plastic.
  • the piston 5 cannot be fashioned from plastic, but rather must be formed, for example, of metal.
  • the piston 5 can be detected by the dosing or analysis pump device 9 via a piston rod 11 that is actuated by an actuator 13 . If the piston rod 11 is moved forward by the actuator 13 , it can move the piston 5 via the connection element 7 deeper into the tank 2 . Fluid 1 is thereby pumped out via the opening 4 .
  • the dosing or analysis pump device 9 controls the actuator 13 and can thus exactly dose the quantity of fluid 1 that leaves via the opening 4 . Due to the linear movement of the piston rod 11 and the consistent cross-section of the tank 2 , the existing volume is directly dependent on the movement of the piston rod 11 , whereby under the circumstances the elasticity of the piston 5 or the connection element 7 must be considered.
  • the invention enables the piston 5 to be retracted by retracting the piston rod 11 , and thereby to pump fluid 1 into the tank 2 via the opening 4 .
  • the opening 4 can be fashioned either as a nozzle to accept fluid 1 , in direct contact with the fluid 1 to be pumped in, or it can be a nozzle or needle that can be placed at the opening 4 . In the event that the opening 4 is not in direct contact with fluid and the piston is retracted, surrounding air is pumped into the tank 2 in place of fluid 1 .
  • connection element 7 has a connection bushing 19 that is formed by a depression in the end of the connection element 7 opposite the piston 5 .
  • the wall of the connection element 7 in the area of this depression, has catch elements 21 that are implemented in FIG. 1 as semicircular jaws.
  • the piston rod 11 has at its end facing the connection element 7 , has a connection plunger 15 that is terminated by a tapering 17 .
  • connection bushing 19 and the connection plunger 15 are formed such that, given movement of the piston rod 11 , they can enlarge in order to automatically close the connection.
  • the cross-section of the tank 2 expands to the end in the section in which the connection element 7 lies. This expansion enables it to avoid catching mechanisms 21 on the way out, due to the elasticity of the connection element 7 from the connection plunger 15 .
  • the connection between the piston rod 11 and the piston 5 in FIG. 1 is therefore not closed.
  • FIG. 2 the same system as in the preceding Figure is shown, however here with a closed connection between the piston 5 and the piston rod 11 .
  • the piston rod 11 was moved far enough by the actuator 13 to engage the connection bushing 19 of the connection element 7 .
  • the piston 5 was thereby moved over the connection element 7 so far that the catch elements 21 in FIG. 2 no longer lie in the expanded section of the tank 2 , but rather are moved into the cylindrical part.
  • Given movement of the catch elements 21 through the tapered section of the tank 2 they are increasingly pressed in the direction of the connection plunger 15 until they are completely pressed in the cylindrical section of the tank 2 .
  • the catch elements 21 are thereby pressed into the tapering 17 of the piston rod 11 , and the connection plunger 15 completely fills the connection bushing 19 .
  • the depth of the connection bushing 10 and the arrangement of the catch elements 21 in the bushing correspond exactly to the length of the connection plunger 15 and the laterally reversed inverted arrangement of the tapering 17 .
  • connection element 7 must be produced from an elastic material, such that the catch elements 21 slant outwardly without interaction of an external force by the connection plunger 15 . Due to this elastic force, they automatically assume the position shown in FIG. 1 , in which the positive-fit connection is not shown. Given retraction of the piston rod 11 , the connection to the connection element 7 again automatically loosens as soon as the catch elements 21 exit from the cylindrical section of the tank 2 in the expanded section.
  • the positive-fit connection thus can be closed automatically and again later automatically released, subject only to the control of the piston rod 11 via the dosing or analysis pump device 9 .
  • the automatic production of the connection between the piston rod 11 and the piston 5 in particular enables the cartridge to connect without complexity with the dosing or analysis pump device 9 . It can easily be operate by untrained personnel, since the actual functional connection to the control of the pump event is automatically produced. It is thus not dependent on the precision with which the cartridge is manually applied to the dosing or analysis pump device 9 . This increases on the one hand the precision in the dosing of small amounts of fluid 1 via the dosing or analysis pump device 9 , and enables the installation and de-installation of the cartridge 3 with minimal effort, in particular in the frequent handling of large quantities.
  • the described system thus has the ability to implement centralized, in particular stationary, analyses using one-time cartridges in large quantities.
  • the cartridge 3 can be produced as a one-time cartridge with the desired degree of purity, in order to also enable an application in purity-critical analyses as are implemented in microbiology, chemistry or medicine. Large numbers of discrete substance quantities are also possible in food production, the chemical industry, or other industrial applications.
  • connection element 7 and the connection plunger 15 are shown enlarged in FIG. 3 in another embodiment.
  • the problem can occur that the piston 5 may not be removed sufficiently far by the piston rod 11 . This therefore causes the catch elements 21 to elastically replace upon retracting the connection plunger 15 .
  • the catch elements Upon retraction of the connection plunger 15 , the catch elements are thereby pulled in a more strongly expanded section of the tank 2 , then released, but then elastically shorten and move to a strongly tapered section.
  • connection plunger 15 If the connection plunger 15 is subsequently moved again, it impacts the catch elements 21 in the strongly tapered section of the tank 2 ; the catch elements 21 then are too close to one another, and the connection plunger 15 can not be inserted into the connection bushing 19 again. A consequence of that would be that no positive-fit connection is produced between piston rod 11 and piston 5 , and the piston 5 could subsequently no longer be retracted after further movement.
  • the catch elements 21 in FIG. 3 exhibit a shape that is less easily elastically deformable in the direction of retraction than in the direction of motion. Ideally, they are not elastic at all in the direction of retraction, but rather remain rigid in their position.
  • the connection plunger 15 can be inserted more easily into the connection bushing 19 than extracted.
  • the catch elements 21 are shown as saw tooth-like tines that “grasp” in the tapering 7 , but they can be gently pressed to the side at their flat side given movement of the piston rod 11 .
  • the connection plunger 15 exhibits a flat back on which the catch elements 21 are placed, without sliding laterally. The tapering 7 and the connection plunger 15 and catch elements 21 interact as a toothed catch.
  • connection element 7 is shown in FIG. 4 in enlarged depiction.
  • the variant shown in FIG. 4 has the same goal as the variant shown in FIG. 3 , namely to prevent the premature release of the connection element 7 in the direction of retraction.
  • additional mechanical catches 23 are provided. These are attached such that they can be folded to the side in the direction of insertion of the piston rod 11 , however in the opposite direction are prevented by stops from folding away.
  • the connection plunger 15 can press the catches to the side, without the a movement force would thereby be exerted on the piston 5 .
  • the catches 23 are applied such that they engage in the tapering 7 as soon as the connection plunger 15 is completely inserted in the connection bushing. For this purpose, the catches 23 must be pressed back by spring force or an elastic suspension into their original position shown in FIG. 4 .
  • the catches 23 ensure a secure positive-fit connection between the connection element 7 and the piston rod 11 that can not release prematurely given retraction, since the catches 23 can not be folded away in the direction of retraction. They are not made of elastic material, but produced from rigid materials, for example from hard plastic or metal. In contrast to this, the connection element 7 is formed of elastic material in order to be able to force the catch elements 21 into their original position, or in addition can have a pre-stressed spring mechanism (not closely shown in FIG. 4 ).
  • connection element 7 it is not made of elastic material, but rather of a hard material such as hard plastic or metal.
  • the automatic production of the connection between piston 5 and piston rod 11 must be ensured by an expanded functionality of the catches 23 . While the catch elements 21 , and thus the catches 23 , could be pressed (in the preceding specified variant, by the expansion of the tank 2 ) sufficiently far away from the connection plunger 15 in order to release the connection upon retraction, this possibility is lost given use of a non-elastic connection element 7 . It is therefore not necessary to fashion the end area of the tank 2 with a continually expanding cross section. Instead, the connection element 7 is likewise shaped cylindrically, like the piston 5 , i.e. with a constant diameter over its length.
  • catches 23 In order to ensure the necessary functionality of the catches 23 , they have in the variant not shown a locking device that blocks their movement in the direction in which they release the connection plunger 15 . In the other direction, their movement is not limited, such that the connection plunger 15 can be inserted into the connection bushing 19 unhindered at any time.
  • the locking device that blocks the movement of the catches 23 can be implemented, for example, as a toothed catch that, upon retraction of the connection element 7 , is released at a predetermined longitudinal section of the tank 2 .
  • the cartridge 3 and the dosing or analysis pump device 9 can be correspondingly fashioned respectively according to individual requirements.
  • the pump device 9 can thus also be a manually controlled device that, for example, provides the removal of blood protein directly into the cartridge 3 in the framework of medical examinations.
  • the actuator 13 would then be provided with a sterile intravenous needle.
  • blood tests for example water tests for environmental technical or chemical examinations should be taken, such an apparatus could be used that would then have a nozzle instead of a needle at the opening 4 of the cartridge.
  • the automatically producible and releasable connection between cartridge 3 and pump device 9 could be used in order to fill or empty a plurality of cartridges 3 in rapid sequence via the pump device.
  • the cartridges 9 can be mechanically stable, cushioned against vibrations, able to be cooled, able to be heated, easily transportable due to their shape, or fashioned in a high-volume system such that they can be integrated.
  • the opening 4 and the piston 5 can be sealed in order to prevent unintentional leaking of fluid 1 .

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hydrology & Water Resources (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
  • Feeding And Controlling Fuel (AREA)
  • Non-Disconnectible Joints And Screw-Threaded Joints (AREA)
US10/672,219 2002-09-26 2003-09-26 Cartridge with connection for a pump-drive and fluid handling system Expired - Fee Related US7182228B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10244960A DE10244960B4 (de) 2002-09-26 2002-09-26 Kartusche mit Verbindung für einen Pump-Antrieb und Handhabungs-System für einen flüssigen oder gasförmigen Stoff
DE10244960.0 2002-09-26

Publications (2)

Publication Number Publication Date
US20040124214A1 US20040124214A1 (en) 2004-07-01
US7182228B2 true US7182228B2 (en) 2007-02-27

Family

ID=31969622

Family Applications (1)

Application Number Title Priority Date Filing Date
US10/672,219 Expired - Fee Related US7182228B2 (en) 2002-09-26 2003-09-26 Cartridge with connection for a pump-drive and fluid handling system

Country Status (4)

Country Link
US (1) US7182228B2 (de)
EP (1) EP1402952B1 (de)
AT (1) ATE384580T1 (de)
DE (2) DE10244960B4 (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2743704A3 (de) * 2010-07-23 2014-06-25 Beckman Coulter, Inc. System oder Verfahren zur Aufnahme analytischer Einheiten
US9186666B2 (en) 2010-01-05 2015-11-17 Hamilton Bonaduz Ag Metering device and metering method

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006051539A2 (en) * 2004-11-12 2006-05-18 Shaul Ozeri A miniature infusion pump for a controlled delivery of medication
JP2008145320A (ja) * 2006-12-12 2008-06-26 Konica Minolta Medical & Graphic Inc マイクロチップ検査装置
EP2030687A1 (de) * 2007-08-13 2009-03-04 Hamilton Bonaduz AG Verschlussanordnung mit Schnappmechanismus
GB2504333B (en) * 2012-07-26 2016-10-05 Ttp Labtech Ltd Liquid dispensing device
IT201900006584A1 (it) * 2019-05-07 2020-11-07 Tecnorama Srl Apparecchiatura per il prelievo e l’erogazione controllata di liquidi con dosaggio volumetrico.

Citations (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE239539C (de)
DE299156C (de)
DE239540C (de)
US2702547A (en) * 1950-02-27 1955-02-22 Antonina S Glass Motor-driven medical injection apparatus and cartridges therefor
US3253592A (en) * 1962-06-08 1966-05-31 Baxter Don Inc Plastic syringe
US3291128A (en) * 1964-01-24 1966-12-13 John G O'neil Hypodermic syringe construction with sealable vent means
US3323682A (en) * 1965-10-06 1967-06-06 Chem Dev Corp Disposable cartridge for gun-type dispensers
US3967759A (en) * 1971-11-11 1976-07-06 Mpl, Inc. Syringe assembly with contained pop-out elastic plug seal
US3986645A (en) * 1972-12-01 1976-10-19 Mpl, Inc. Liquid dispenser
US4057050A (en) * 1974-11-29 1977-11-08 Sarstedt W Devices for extracting blood
GB1525829A (en) 1975-11-05 1978-09-20 Eppendorf Geraetebau Netheler Pipette devices
US4185628A (en) * 1978-05-31 1980-01-29 Kopfer Rudolph J Compartmental syringe
EP0155087A2 (de) 1984-03-12 1985-09-18 Baxter Travenol Laboratories, Inc. Handgehaltene Pipette mit wegwerfbarem Kapillar
EP0181957A1 (de) 1984-11-20 1986-05-28 HTL High-Tech Lab Herstellung und Vertrieb medizinisch technischer Erzeugnisse GmbH Pipette mit veränderlichem Dosiervolumen
US4673396A (en) * 1982-11-22 1987-06-16 Ray Urbaniak Syringe cartridge
EP0226867A2 (de) 1985-12-17 1987-07-01 Hamilton Bonaduz AG Pipette und Pipettiervorrichtung
US4869403A (en) * 1987-03-18 1989-09-26 Alfred Fischbach Kg Cartridge for pasty materials
US4890627A (en) * 1987-11-09 1990-01-02 Habley Medical Technology Corporation Manually evacuated suction tube
US5238003A (en) * 1992-02-07 1993-08-24 Baidwan Balinderjeet S Plunger tip for blood gas syringe
EP0600580A2 (de) 1992-11-18 1994-06-08 Ultradent Products, Inc. Spritzgerät mit abnehmbarem Misch und Ausgabeende
US5499751A (en) * 1992-01-21 1996-03-19 Meyer; Gabriel Device for storing a liquid medicinal substance and for administering eye drops
EP0734769A1 (de) 1995-03-31 1996-10-02 Roche Diagnostics GmbH Deckel zum Verschluss von Gefässen
DE19652272A1 (de) 1996-12-16 1998-08-06 Alfred Von Schuckmann Kartusche für Ejektoreinrichtung
DE19708151A1 (de) 1997-02-28 1998-09-10 Eppendorf Geraetebau Netheler Pipettiervorrichtung
DE19826065A1 (de) 1998-06-12 1999-12-16 Eppendorf Geraetebau Netheler Pipettiervorrichtung

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD239540A1 (de) * 1985-07-12 1986-10-01 Univ Schiller Jena Hohlkolbenpipette
DD239539A1 (de) * 1985-07-19 1986-10-01 Univ Schiller Jena Hohlkolbenpipette
FR2651314A1 (fr) * 1989-08-25 1991-03-01 Taddei Andre Dispositif portatif pour effectuer des dosages multiples d'un produit liquide ou pateux.

Patent Citations (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE239539C (de)
DE299156C (de)
DE239540C (de)
US2702547A (en) * 1950-02-27 1955-02-22 Antonina S Glass Motor-driven medical injection apparatus and cartridges therefor
US3253592A (en) * 1962-06-08 1966-05-31 Baxter Don Inc Plastic syringe
US3291128A (en) * 1964-01-24 1966-12-13 John G O'neil Hypodermic syringe construction with sealable vent means
US3323682A (en) * 1965-10-06 1967-06-06 Chem Dev Corp Disposable cartridge for gun-type dispensers
US3967759A (en) * 1971-11-11 1976-07-06 Mpl, Inc. Syringe assembly with contained pop-out elastic plug seal
US3986645A (en) * 1972-12-01 1976-10-19 Mpl, Inc. Liquid dispenser
US4057050A (en) * 1974-11-29 1977-11-08 Sarstedt W Devices for extracting blood
GB1525829A (en) 1975-11-05 1978-09-20 Eppendorf Geraetebau Netheler Pipette devices
US4185628A (en) * 1978-05-31 1980-01-29 Kopfer Rudolph J Compartmental syringe
US4673396A (en) * 1982-11-22 1987-06-16 Ray Urbaniak Syringe cartridge
EP0155087A2 (de) 1984-03-12 1985-09-18 Baxter Travenol Laboratories, Inc. Handgehaltene Pipette mit wegwerfbarem Kapillar
EP0181957A1 (de) 1984-11-20 1986-05-28 HTL High-Tech Lab Herstellung und Vertrieb medizinisch technischer Erzeugnisse GmbH Pipette mit veränderlichem Dosiervolumen
EP0226867A2 (de) 1985-12-17 1987-07-01 Hamilton Bonaduz AG Pipette und Pipettiervorrichtung
US4869403A (en) * 1987-03-18 1989-09-26 Alfred Fischbach Kg Cartridge for pasty materials
US4890627A (en) * 1987-11-09 1990-01-02 Habley Medical Technology Corporation Manually evacuated suction tube
US5499751A (en) * 1992-01-21 1996-03-19 Meyer; Gabriel Device for storing a liquid medicinal substance and for administering eye drops
US5238003A (en) * 1992-02-07 1993-08-24 Baidwan Balinderjeet S Plunger tip for blood gas syringe
EP0600580A2 (de) 1992-11-18 1994-06-08 Ultradent Products, Inc. Spritzgerät mit abnehmbarem Misch und Ausgabeende
EP0734769A1 (de) 1995-03-31 1996-10-02 Roche Diagnostics GmbH Deckel zum Verschluss von Gefässen
DE19652272A1 (de) 1996-12-16 1998-08-06 Alfred Von Schuckmann Kartusche für Ejektoreinrichtung
DE19708151A1 (de) 1997-02-28 1998-09-10 Eppendorf Geraetebau Netheler Pipettiervorrichtung
DE19826065A1 (de) 1998-06-12 1999-12-16 Eppendorf Geraetebau Netheler Pipettiervorrichtung

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9186666B2 (en) 2010-01-05 2015-11-17 Hamilton Bonaduz Ag Metering device and metering method
EP2743704A3 (de) * 2010-07-23 2014-06-25 Beckman Coulter, Inc. System oder Verfahren zur Aufnahme analytischer Einheiten
US8932541B2 (en) 2010-07-23 2015-01-13 Beckman Coulter, Inc. Pipettor including compliant coupling

Also Published As

Publication number Publication date
EP1402952B1 (de) 2008-01-23
ATE384580T1 (de) 2008-02-15
DE10244960A1 (de) 2004-04-08
EP1402952A1 (de) 2004-03-31
DE50309068D1 (de) 2008-03-13
DE10244960B4 (de) 2004-12-02
US20040124214A1 (en) 2004-07-01

Similar Documents

Publication Publication Date Title
US8505396B2 (en) Fluid transfer device
US10684303B2 (en) Method for protecting and unprotecting the fluid path in a controlled environment enclosure
KR102615068B1 (ko) 제어된 환경 인클로저에서 유체 경로를 보호 및 보호 해제하기 위한 장치 및 방법
US7182228B2 (en) Cartridge with connection for a pump-drive and fluid handling system
EP2705137B1 (de) Automatisches aseptisches probennahmeventil zur probennahme aus geschlossenen behältern
CN114958990A (zh) 使用分子诊断测试装置检测靶核酸的方法
US20100123094A1 (en) Fluid transfer device
EP2143491A1 (de) Vorrichtung zum Analysieren einer chemischen oder biologischen Probe
US20070193375A1 (en) System and method for sampling liquids
JP2010145397A (ja) 媒体移送用の装置
CN108025168B (zh) 用于药物、生物工艺应用、以及食品/乳制品应用的柔性管道管理系统
WO2006122268A2 (en) Sanitary diaphragm pump for critical bioprocess applications
US20180372598A1 (en) Method, extraction instrument, dispensing instrument and kit for pretreating an in particular biological sample
US9389151B2 (en) Fixed volume aseptic sampling valve for sampling from enclosed containers
JP4216471B2 (ja) 圧縮密封部分を有する自動サンプラーの注入器
US20070048194A1 (en) Use of a disposable container, microfluidic device and method for processing molecules
JP2010065584A (ja) 送液ポンプ及び該ポンプによる送液方法
US9568113B2 (en) Fluid transfer device
US20090104076A1 (en) Sample preparation cartridge and system
EP2042237A1 (de) Reaktorsystem mit Reaktionskammern und Verfahren zum Füllen und Entleeren der Reaktionskammern
Loth et al. Investigation of different liquid silicone rubbers for micro pinch valves
US20060024201A1 (en) Flexible reactor
US11602750B2 (en) Customizable sample processing device
Loth et al. Microfluidic high speed pinch valve
Becker et al. Stationary microfluidics: molecular diagnostic assays by moving magnetic beads through non-moving liquids

Legal Events

Date Code Title Description
AS Assignment

Owner name: SIEMENS AKTIENGESELLSCHAFT, GERMANY

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:KRUEGER, ANDREAS;REEL/FRAME:014955/0833

Effective date: 20030929

AS Assignment

Owner name: SIEMENS AKTIENGESELLSCHAFT, GERMANY

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:SIEMENS AKTIENGESELLSCHAFT;REEL/FRAME:016134/0712

Effective date: 20040914

Owner name: DIRECTIF GMBH, GERMANY

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:SIEMENS AKTIENGESELLSCHAFT;REEL/FRAME:016134/0712

Effective date: 20040914

FEPP Fee payment procedure

Free format text: PAYOR NUMBER ASSIGNED (ORIGINAL EVENT CODE: ASPN); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY

FPAY Fee payment

Year of fee payment: 4

REMI Maintenance fee reminder mailed
LAPS Lapse for failure to pay maintenance fees
STCH Information on status: patent discontinuation

Free format text: PATENT EXPIRED DUE TO NONPAYMENT OF MAINTENANCE FEES UNDER 37 CFR 1.362

FP Lapsed due to failure to pay maintenance fee

Effective date: 20150227