US6375642B1 - Method of and device for improving a drainage of aqueous humor within the eye - Google Patents
Method of and device for improving a drainage of aqueous humor within the eye Download PDFInfo
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- US6375642B1 US6375642B1 US09/503,884 US50388400A US6375642B1 US 6375642 B1 US6375642 B1 US 6375642B1 US 50388400 A US50388400 A US 50388400A US 6375642 B1 US6375642 B1 US 6375642B1
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- schlemm
- canal
- support element
- aqueous humor
- scleral flap
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/00781—Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
Definitions
- the present invention relates, in general, to a method for improving a drainage of aqueous humor within the eye of a living being, and to a device for maintaining the improved drainage of aqueous humor.
- trabecular meshwork If the trabecular meshwork is either partially or completely non-functional due to an obstruction or back-up, or pathological changes, natural flow of the aqueous humor becomes limited, thereby raising the pressure inside the eye which negatively impacts on the blood circulation and the function of the visual nerve.
- the resulting disease is commonly known under the name “glaucoma” which may lead to blindness in the eye.
- U.S. Pat. No. 5,360,399 describes a method and apparatus, by which the trabecular meshwork, which is located upstream of the Schlemm's canal and which due to pathological changes, may either partially or completely obstruct the outflow of aqueous humor, is slightly widened by the hydraulic pressure of a highly viscous aqueous solution, which when injected into the Schlemm's canal opens it at several location points, so that an outflow of the aqueous humor can be realized.
- a method in accordance with the present invention which includes the following steps: incising a first lamellar section of the sclera to form a first scleral flap; lifting the first scleral flap upwards in the direction of the cornea, thereby creating a recess in the sclera; incising a second lamellar section in the area of the recess to thereby form a second scleral flap and a support surface bounding the scleral flap; lifting the second scleral flap upwards in the direction of the first sclera flap, thereby creating a second recess and exposing a portion of the Schlemm's canal; implanting in the lumen of the Schlemm's canal on each of both sides of the second recess, and, optionally, in the exposed portion of the Schlemm's canal, at least one support element, with each support element being made of a material that is decomposable by the tissue of the
- the support element is suitably made of biolytically decomposable material and may have a ring-shaped or spherically-shaped configuration or may have an elongate, tubular configuration to hold the lumen in expanded position.
- the support element may also be formed as a braided mesh of elongate configuration, or as an elongate helical spring.
- the second scleral flap can be detached along a portion thereof in the area of the Schwalbe's line from the partially aqueous humor permeable Descemet's membrane by applying a slight pressure force to thereby form a gap-shaped opening (window).
- the detached portion of the second scleral flap can thereby be held in open disposition by protrusions projecting out from the support element, so that the anterior chamber is fluidly connected in the area of the iridocorneal angle via the Descemet's membrane and the gap-shaped opening with the subscleral space.
- aqueous humor flowing naturally via the trabecular meshwork into the Schlemm's canal is additionally conducted from the anterior chamber through the partially aqueous humor-permeable Descemet's membrane and through the gap-shaped opening into the scleral space in fluid communication with the Schlemm's canal.
- This object is attained in accordance with the present invention by providing a support element for implantation into the lumen of the Schlemm's canal, with the support element having a ring shaped configuration, spherical shaped configuration or tubular shaped configuration, and being made of a decomposable material, in particular of a material that can be decomposed by the tissue of the Schlemm's canal and/or the aqueous humor.
- FIG. 1 is a schematic illustration of a portion of a eye, on an enlarged scale, showing a first parabolic incision in the sclera for forming a first scleral flap which is folded upwards;
- FIG. 2 is a schematic view of the portion of the eye of FIG. 1, taken along the line II—II in FIG. 1;
- FIG. 3 is a schematic illustration of the portion of the eye of FIG. 1, showing a second parabolic incision within the area of first incision for formation of a second scleral flap which is folded upwards;
- FIG. 4 is a schematic view of the portion of the eye of FIG. 3, illustrating both upwardly folded scleral flaps and taken along the line IV—IV in FIG. 3;
- FIG. 5 is a schematic illustration of the portion of the eye of FIG. 3, depicting a probe for insertion into the exposed Schlemm's canal;
- FIG. 6 is a schematic view of the portion of the eye of FIG. 4, illustrating the application of a swab for applying a small pressure force against the Schwalbe's Line in the area of the two upwardly folded scleral flaps;
- FIG. 7 is a schematic view of the portion of the eye of FIG. 6, illustrating a detachment of the Descemet's membrane from the cornea and the severed second scleral flap;
- FIG. 8 is a schematic view of the portion of the eye of FIG. 4, illustrating exemplified support elements according to the present invention for implantation in the lumen of the Schlemm's canal;
- FIG. 9 is a schematic view of the portion of the eye of FIG. 4, illustrating further exemplified support elements according to the present invention for implantation in the lumen of the Schlemm's canal;
- FIG. 10A is a detailed perspective view, on an enlarged scale, of a first variation of a support element according to the present invention.
- FIG. 10B is a detailed perspective view, on an enlarged scale, of a second variation of a support element according to the present invention.
- FIG. 10C is a detailed view, on an enlarged scale, of a third variation of a support element according to the present invention.
- FIG. 10D is a detailed view, on an enlarged scale, of a fourth variation of a support element according to the present invention, for exemplified implantation in the exposed portion of the Schlemm's canal;
- FIG. 10E is a detailed view, on an enlarged scale, of the support element of FIG. 10D, taken along the line E—E in FIG. 10D;
- FIG. 10F is a detailed view, on an enlarged scale, of a fifth variation of a support element according to the present invention.
- FIG. 10G is a detailed view, on an enlarged scale, of a sixth variation of a support element according to the present invention.
- FIG. 11 is a schematic view of the portion of the eye of FIG. 8, illustrating the exemplified implantation of support elements of FIG. 10A in the Schlemm's canal and the exemplified implantation of support elements of FIG. 10B in the exposed portion of the Schlemm's canal;
- FIG. 12 is a schematic view of the portion of the eye of FIG. 11, taken along the line XII—XII in FIG. 11, illustrating the exemplified implantation of a support element of FIG. 10 E and folding back of the first scleral flap;
- FIG. 13 is a schematic view of the portion of the eye of FIG. 8, illustrating the exemplified implantation of support elements of FIG. 10A in the Schlemm's canal and the exemplified implantation of a support element of FIG. 10F in the exposed portion of the Schlemm's canal;
- FIG. 14 is a schematic view of the portion of the eye of FIG. 8, illustrating the exemplified implantation of support elements of FIG. 10 A and FIG. 10B in the Schlemm's canal and the exemplified implantation of a support element of FIG. 10G in the exposed portion of the Schlemm's canal.
- FIG. 1 there is shown a first process step for improving a drainage of aqueous humor in an eye 15 which is shown only schematically by way of a portion of an iris 2 , a cornea 4 , a sclera 3 , a partial section of the circular Schlemm's canal 5 (sinus venosus sclerae) and a channel system 3 ′ which is comprised of a multitude of channels for conducting the aqueous humor.
- a first process step for improving a drainage of aqueous humor in an eye 15 which is shown only schematically by way of a portion of an iris 2 , a cornea 4 , a sclera 3 , a partial section of the circular Schlemm's canal 5 (sinus venosus sclerae) and a channel system 3 ′ which is comprised of a multitude of channels for conducting the aqueous humor.
- a first incision of approximately parabolic shape is made in the sclera 3 to form a scleral flap 10 which is lifted upwards in the direction towards the cornea 4 to thereby expose a corresponding recess 11 which is bounded by a circumferentially extending side wall 11 ′.
- the scleral flap 10 is held in upwardly folded position by a tool or other means which are not shown for the sake of simplicity but are generally known by the artisan.
- FIG. 2 which is a sectional view of the portion of the eye 15 , taken along the line II—II in FIG. 1, shows a portion of the sclera 3 , a portion of the cornea 4 with the Descemet's membrane 6 and the Schwalbe's line 7 , a portion of the iris 2 and a portion of the lens 9 connected to the sclera 3 by means of the zonular fibers 9 ′. Further shown is the first scleral flap 10 , which has been lifted upwards in the direction of arrow 16 and the corresponding recess 11 , in addition to the Schlemm's canal 5 with the trabecular meshwork 8 disposed anteriorly thereof.
- Arrows 1 and 1 ′ in FIG. 2 designate essentially the circulation of aqueous humor and the natural drainage thereof.
- Aqueous humor which in a healthy eye, regenerates continually, flows according to arrow 1 from the posterior chamber H to the anterior chamber V and is conducted at the iridocorneal angle V′ (angulus irido-cornealis) in the direction of arrow 1 ′ via the trabecular meshwork 8 into the Schlemm's canal 5 and from there, via the natural channel system 3 ′ (FIG. 1) to a natural venous system (not shown).
- the trabecular meshwork 8 When the trabecular meshwork 8 is partially or completely non-functional due to back-up or like blockage, the natural drainage of aqueous humor is limited to such an extent that the pressure inside the eye 15 rises to thereby restrict the blood circulation and thus the functionality of the optic nerve (not shown).
- the resulting disease is commonly known under the name “glaucoma” and may lead to blindness of the affected eye.
- a micro-surgical procedure is carried by which the conjunctiva (not shown) is retracted with a suitable tool for exposing a sufficient portion of the sclera 3 .
- the formed scleral flap 10 is folded upwards in the direction towards the cornea 4 , thereby exposing the first recess 11 with its circumferential side wall 11 ′.
- the first incision may cover an area of, for example, 3 mm ⁇ 3 mm with a depth which is so selected that the thickness 10′ of the first sclera flap 10 is approximately 1 ⁇ 3 of the natural thickness of the sclera 3 in this zone, as depicted in FIG. 2 .
- the Schlemm's canal 5 is not yet exposed.
- a second incision is made within the area of the first incision to form a second parabolic scleral flap 12 which is then lifted upwards in the direction of the cornea 4 in a direction of arrow 16 ′ (FIG. 4 ), so that a second recess 13 is defined in correspondence with the second scleral flap 12 and bounded by a support surface 14 .
- the depth of the second incision can, for example, be selected such that the Schlemm's canal 5 is exposed by a portion, denoted in its entirety by reference numeral 18 .
- two inlets 17 and 17 ′ of the Schlemm's canal 5 in opposite disposition in the recess 13 are accessible for injection of an expanding medium by means of a probe, shown in FIG. 5 .
- the second scleral flap 12 is so formed that the Schlemm's canal 5 includes a depression 5 ′ which exhibits a substantially grooved configuration and extends across the entire width of the second scleral flap 12 .
- FIG. 4 shows the portion of eye 15 , taken along the line IV—IV in FIG. 3, with the two scleral flaps 10 , 12 folded upwards in the direction of arrows 16 , 16 ′ and held in place by suitable means (not shown).
- the second incision results in a thickness 12 ′ of the second scleral flap 12 that allows sufficient exposure and accessibility of the Schlemm's canal 5 via the inlets 17 , 17 ′ and the exposed portion 18 .
- This is essentially realized by so selecting the depth of second incision that the groove-shaped depression 5 ′ of the Schlemm's canal 5 remains at the inside 12 ′′ of the second scleral flap 12 .
- FIGS. 3 and 4 also show the recesses 11 , 13 in the sclera 3 with the side wall 11 ′ and the support surface 14 .
- FIG. 5 which is an enlarged illustration of the eye 15 of FIG. 3 and shows a portion of the sclera 3 and the two upwardly folded sclera flaps 10 , 12 as well as the second recess 13 and the lateral support surface 14 of the sclera 3 with the channel system 3 ′, depicts a next process phase, in which a suitable medium, preferably a high viscosity sodium hyaluronate solution is injected into the two lateral inlets 17 and 17 ′ of the Schlemm's canal 5 by an injection unit, generally designated by reference numeral 25 to expand the lumen 19 of the Schlemm's canal 5 .
- the injection unit 25 includes a probe 24 which, in the nonlimiting example of FIG.
- the injection unit 25 with the probe 24 is withdrawn from the inlet 17 and can be turned for insertion in the opposite inlet 17 ′ of the Schlemm's canal 5 for injection of the expanding medium and expansion of the lumen 19 .
- the injection unit 25 is connected via a supply conduit 28 to a pressure source 26 , indicated schematically only, which may be formed by a single-chamber syringe or like device.
- the injected medium is forced into the lumen 19 of Schlemm's canal 5 in the direction of arrow 27 , by means of the manually or electrically operated pressure source 26 via the supply conduit 28 , adapter 29 , and probe 24 , for expansion of the lumen 19 .
- the injection unit 25 is removed. It will be appreciated by persons skilled in the art that operation and structure of such injection unit 25 are generally known by the artisan and do not form part of the present invention so that a detailed description thereof has been omitted for the sake of simplicity.
- FIG. 7 there is shown a further, optional, process step, after expansion of the Schlemm's canal 5 and withdrawal of the injection unit 25 , representing a detachment the Descemet's membrane 6 from the inner surface of the cornea 4 in the area of the Schwalbe's line 7 .
- the detachment of the Descemet's membrane 6 is realized by using a swab 20 or like device to create an opening (window) 21 between the second scleral flap 12 and the Descemet's membrane 6 , as shown schematically on an enlarged scale in FIG. 7 .
- the opening 21 is substantially gap-shaped and extends in a manner not shown here across the entire width of the exposed portion 18 or second recess 13 , as best seen in FIG. 8 .
- the opening 21 provides a further connection between the anterior chamber V of the eye 15 and the second recess 13 so that aqueous humor can drain, apart from the natural outflow via the trabecular meshwork 8 in the direction of arrow 1 ′, also via the substantially transparent Descemet's membrane 6 , which is partly permeable for aqueous humor, in the direction of arrow 1 ′′, as shown in FIG. 7, and via the opening 21 to the recess 13 which is fluidly connected with the Schlemm's canal 5 .
- the second recess 13 which essentially conforms to the scleral flap 12 , forms a reservoir (FIG. 12) for aqueous humor which is drained from the reservoir-forming recess 13 through both lateral inlets 17 , 17 ′ into the Schlemm's canal 5 , and from there via the channel system 3 ′.
- the second scleral flap 12 is then, preferably, severed with a suitable surgical instrument (not shown), as shown in FIG. 8 . It will be appreciated by persons skilled in the art, that the separation of the second sclera flap 12 may be carried out also before detachment of the Descemet's membrane 6 by means of the swab 20 to form the gap-shaped opening 21 .
- FIG. 8 there is shown a schematic view of the eye 15 , after severance of the second scleral flap 12 , and illustration of the exposed portion 18 of the Schlemm's canal 5 and both confronting inlets 17 , 17 ′.
- Implanted into the lumen 19 of the Schlemm's canal 5 on each of both sides of the exposed portion 18 are two support elements in spaced-apart side-by-side disposition.
- two substantially ring-shaped support elements 30 are arranged on one side of the exposed portion 18
- two spherical support elements 33 are arranged on the other side of the exposed portion 18 .
- FIG. 9 shows further exemplified support elements for implantation, that is a support element 45 in the form of a braided mesh is arranged on one side of the exposed portion 18 , and a support element 50 in the form of a helical spring is arranged on the other side of the exposed portion 18 .
- FIG. 10A depicts a detailed perspective view, on an enlarged scale, of the support element 30 .
- the support element 30 has a throughbore 32 and exhibits, preferably, an outer circular ring shape or elliptical ring shape.
- the support element 30 is made of a material that will automatically conform to the lumen 19 of the Schlemm's canal 5 .
- the support element 30 has a width 31 which is selected such that the support element 30 can be implanted in stable position in the lumen 19 and is prevented from toppling over in axial direction of the lumen 19 .
- FIG. 10B depicts a detailed view, on an enlarged scale, of the spherical support element 33 .
- the support element 33 has at least one throughbore 34 , preferably several bores 34 which are spaced in circumferential direction.
- FIGS. 10C to 10 E show further examples of support elements in accordance with the present invention. It will be appreciated by persons skilled in the art that the various configurations of support elements, described here, can be combined in any desired manner for implantation in the lumen 19 of the Schlemm's canal 5 . Thus, the types of support elements implanted in FIGS. 8 and 9 are shown only for illustrative purposes.
- FIG. 10C shows a support element 35 which is made from a flexible tube and has an outer configuration of circular ring shape or elliptic shape.
- the support element 35 is traversed in axial direction by a throughbore 36 which is in communication with a plurality of inlet openings 37 spaced in axial direction.
- the support element 35 is freely movable in its disposition and orientation, as shown schematically by broken lines, and thus can easily conform, as a consequence of its flexibility, to the inner configuration of the lumen 19 when inserted in the Schlemm's canal 5 .
- the flexibility is however so limited that a kinking is eliminated.
- FIG. 10D shows a support element 40 which is also made from an elongate flexible tube 41 and is traversed in axial direction by a throughbore 41 ′ which is communication with a plurality of apertures 42 , 42 ′ spaced from one another in axial direction.
- the support element 40 has further arranged, preferably formed, thereon, a plurality of protrusions 43 , 43 ′, 43 ′′ which are spaced from one another in axial direction.
- the apertures 42 , 42 ′, which communicate with the throughbore 41 ′, are preferably arranged in diametrically confronting disposition on the longer side of the support element 40 . As shown in FIG.
- the support element 40 has an outer elliptic configuration which substantially conforms to the configuration of the Schlemm's canal 5 .
- This type of support element 40 is used, primarily, for implantation in the exposed portion 18 of the Schlemm's canal 5 in the area of the second scleral recess 13 of the sclera 3 .
- the function of the support element 40 will be described in more detail with reference to FIGS. 11 and 12.
- FIG. 10F shows in more detail the support element 45 in the form of a braided mesh.
- the support element 45 is made from a plurality of threads 46 (filaments) which are helically intertwined to form the braided mesh, which has spacings 47 , 47 ′, 47 ′′ formed between the threads 46 for drainage of aqueous humor.
- the support element 45 is capable to conform by itself to the outer configuration of the lumen 19 of the Schlemm's canal 5 .
- FIG. 10G shows in more detail the support element 50 , which, for example, is formed from a single, helically twined thread 51 (filament). Aqueous humor is drained between spacings 52 , 52 ′ of the individual windings of the support element 50 .
- the support element 50 is capable to conform by itself to the outer configuration of the lumen 19 of the Schlemm's canal 5 .
- the elongate support elements 35 , 40 , 45 or 50 may be implanted in the portion 18 of the Schlemm's canal 5 , exposed in the area of the second recess 13 of the sclera 3 , as well as in the lumen 19 of the Schlemm's canal 5 . Implantation of the elongate support element 35 , 45 , 50 in the exposed portion of the Schlemm's canal 5 is also feasible, as will be described in more detail with reference with FIGS. 13 and 14.
- FIG. 11 shows implantation of spaced apart, ring-shaped support elements 30 on both sides of the second recess 13 in the lumen 19 of the Schlemm's canal 5 , whereas a support element 40 is placed in the area of the second recess 13 of the sclera 3 in the exposed portion 18 of the Schlemm's canal 5 .
- the support element 40 is so disposed in the exposed portion 18 of the Schlemm's canal 5 that the residual portion 12 . 1 , which has been left from the second scleral flap 12 and extends across the entire width of the second recess 13 , rests on the protrusions 43 , 43 ′, 43 ′′ of the support element 40 .
- the first sclera flap 10 is folded back and, as shown in FIG. 12, placed on the parabolic support surface 14 . Subsequently, the first scleral flap 10 is sutured partially, in a manner known per se, to the sclera 3 .
- a subscleral space 13 ′ is created in the form of the flat recess 13 behind the first scleral flap 10 and preferably filled by means of a syringe (not shown) with high viscosity medium, such as sodium hyaluronate, before completely rejoining the first scleral flap 10 . This prevents an inside surface 10 ′′ of the repositioned first scleral flap 10 to come into contact with the inside surface 13 ′′ of the recess 13 , as shown in FIG. 12 .
- FIG. 12 shows the implanted support element 40 according to FIG. 11 along the section line XII—XII on an enlarged scale, with the scleral flap 10 being folded back, and the residual portion 12 . 1 of the second scleral flap 12 , separated from the Descemet's membrane 6 and placed on the protrusions 43 , 43 ′, 43 ′′.
- the provision of the protrusions 43 , 43 ′, 43 ′′ prevents a closing of the gap-shaped opening 21 across the entire width of the exposed portion 18 of the Schlemm's canal 5 .
- the gap-shaped opening 21 provides an additional connection between the iridocorneal angle V′ of the anterior chamber V and the second recess 13 .
- Aqueous humor can thus drain in addition to the natural drainage in the direction of arrow 1 ′ via the trabecular meshwork 8 also in the direction of arrow 1 ′′ via the substantially transparent and partially permeable Descemet's membrane 6 and via the gap-shaped opening 21 to the recess 13 .
- the flat recess 13 which has a configuration that approximates the second scleral flap 12 , forms the subscleral space 13 ′ or a reservoir for aqueous humor, when the scleral flap 10 is folded back.
- aqueous humor is drained via the two inlets 17 , 17 ′, fluidly connected to the subscleral space 13 ′, into the lumen 19 of the Schlemm's canal 5 , and from there into the channel system 3 ′.
- FIG. 13 shows implantation of spaced apart, ring-shaped support elements 30 , according to FIG. 10A, on both sides of the second recess 13 in the lumen 19 of the Schlemm's canal 5 .
- support elements 30 or in combination with the support elements 30 , several spaced-apart spherical support elements 33 may be used for implantation in the lumen 19 .
- FIG. 14 shows implantation of two spaced-apart, ring-shaped support elements 30 , according to FIG.10A on one side in the lumen 19 , whereas two spaced-apart, spherical support elements 33 , according to FIG. 10B, are positioned on the other, opposite side in the lumen 19 .
- This non-limiting example includes also the implantation of the support element 50 according to FIG. 10G in the exposed portion 18 of the Schlemm's canal 5 .
- the support elements 30 , 33 , 35 , 45 , 50 are made from decomposable material, in particular material that is biolytically decomposable by the tissue of the Schlemm's canal 5 and/or the aqueous humor. Especially suitable are materials that biolytically decompose within 2 to 12 months after implantation. Examples for materials used for support elements 30 , 33 , 35 , 45 , 50 include a cross-linked sodium hyaluronate. There is, however, also the option, to make the support element, in particular the elongate support element 35 , 40 , 45 , 50 that is implantable in the exposed portion 18 of the Schlemm's canal 5 , from biocompatible material, e.g. plastic material, rust-free steel or special steel such as silver, gold or platinum.
- biocompatible material e.g. plastic material, rust-free steel or special steel such as silver, gold or platinum.
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Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
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US09/503,884 US6375642B1 (en) | 2000-02-15 | 2000-02-15 | Method of and device for improving a drainage of aqueous humor within the eye |
AU10027/01A AU1002701A (en) | 2000-02-15 | 2001-01-03 | A method of and device for improving a drainage of aqueous humor within the eye |
CA002331868A CA2331868A1 (fr) | 2000-02-15 | 2001-01-22 | Technique et dispositif d'amelioration du drainage de l'humeur aqueuse que renferme un oeil |
EP01810106A EP1125568A3 (fr) | 2000-02-15 | 2001-02-02 | Méthode et dispositif pour améliorer et maintenir l'écoulement de l'humeur aqueuse d'un oeil |
JP2001032379A JP2001245916A (ja) | 2000-02-15 | 2001-02-08 | 眼の房水の排出を改善する方法とそのための装置 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US09/503,884 US6375642B1 (en) | 2000-02-15 | 2000-02-15 | Method of and device for improving a drainage of aqueous humor within the eye |
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US6375642B1 true US6375642B1 (en) | 2002-04-23 |
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US09/503,884 Expired - Lifetime US6375642B1 (en) | 2000-02-15 | 2000-02-15 | Method of and device for improving a drainage of aqueous humor within the eye |
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US (1) | US6375642B1 (fr) |
EP (1) | EP1125568A3 (fr) |
JP (1) | JP2001245916A (fr) |
AU (1) | AU1002701A (fr) |
CA (1) | CA2331868A1 (fr) |
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US6450984B1 (en) | 1999-04-26 | 2002-09-17 | Gmp Vision Solutions, Inc. | Shunt device and method for treating glaucoma |
US20020143284A1 (en) * | 2001-04-03 | 2002-10-03 | Hosheng Tu | Drug-releasing trabecular implant for glaucoma treatment |
WO2002087418A2 (fr) * | 2001-05-02 | 2002-11-07 | Glaukos Corporation | Derivation trabeculaire a bifurcation pour le traitement du glaucome |
US20020169130A1 (en) * | 2001-05-03 | 2002-11-14 | Hosheng Tu | Medical device and methods of use for glaucoma treatment |
US20020188308A1 (en) * | 2001-04-07 | 2002-12-12 | Hosheng Tu | Glaucoma stent and methods thereof for glaucoma treatment |
US6533768B1 (en) * | 2000-04-14 | 2003-03-18 | The Regents Of The University Of California | Device for glaucoma treatment and methods thereof |
US20030055372A1 (en) * | 1999-04-26 | 2003-03-20 | Lynch Mary G. | Shunt device and method for treating glaucoma |
US20030060752A1 (en) * | 2000-04-14 | 2003-03-27 | Olav Bergheim | Glaucoma device and methods thereof |
US20030088260A1 (en) * | 2001-11-08 | 2003-05-08 | Smedley Gregory T. | Combined treatment for cataract and glaucoma treatment |
US20030097151A1 (en) * | 2001-10-25 | 2003-05-22 | Smedley Gregory T. | Apparatus and mitochondrial treatment for glaucoma |
US20030153863A1 (en) * | 2002-02-13 | 2003-08-14 | Patel Anilbhai S. | Implant system for glaucoma surgery |
US20030187385A1 (en) * | 2000-04-14 | 2003-10-02 | Bergheim Olav B. | Implant with anchor |
US20040024345A1 (en) * | 2002-04-19 | 2004-02-05 | Morteza Gharib | Glaucoma implant with valveless flow bias |
US20040050392A1 (en) * | 2001-08-28 | 2004-03-18 | Hosheng Tu | Glaucoma stent for treating glaucoma and methods of use |
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Also Published As
Publication number | Publication date |
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EP1125568A2 (fr) | 2001-08-22 |
CA2331868A1 (fr) | 2001-08-15 |
JP2001245916A (ja) | 2001-09-11 |
AU1002701A (en) | 2001-08-16 |
EP1125568A3 (fr) | 2003-09-03 |
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