US5064057A - Support for anastomosing or connecting living organs - Google Patents
Support for anastomosing or connecting living organs Download PDFInfo
- Publication number
- US5064057A US5064057A US07/501,363 US50136390A US5064057A US 5064057 A US5064057 A US 5064057A US 50136390 A US50136390 A US 50136390A US 5064057 A US5064057 A US 5064057A
- Authority
- US
- United States
- Prior art keywords
- support
- polysaccharide
- anastomosing
- monosaccharide
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/11—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/042—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/048—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L39/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions of derivatives of such polymers
- C08L39/04—Homopolymers or copolymers of monomers containing heterocyclic rings having nitrogen as ring member
- C08L39/06—Homopolymers or copolymers of N-vinyl-pyrrolidones
Definitions
- the present invention relates to a novel support for anastomosing or connecting living organs. More particularly, the present invention relates to a support with high safety which can be used as a support for a living tissue in anastomosing or connecting living organs in a living body and which eliminates the need for being taken out after the surgery but is quickly dissolved away in body fluid in the living body.
- a support is seldom used in anastomosing or connecting living organs, especially when sutures are performed.
- a support is often utilized when an adhesive is employed for anastomosing and connecting.
- the incised wound is first properly closed by the operator's fingers or by using a support and/or other instruments, then a piece of cloth made of polyethylene terephthalate or such cut to a width of 1.5 cm and a length slightly greater than the length of the wound is placed on the wound surface and an adhesive is dropped thereonto for effecting desired skin adhesion.
- a support for anastomosing or connecting living organs in a living body which comprises a material selected from the group consisting of monosaccharide, oligosaccharide, polysaccharide, a mixture thereof, and polyvinyl pyrrolidone.
- the support for anastomosis or connection according to the present invention is characterized in that it is produced from a material selected from monosaccharide, oligosaccharide, polysaccharide, a mixture thereof, a polyvinyl pyrrolidone.
- Many of the monosaccharide, oligosaccharide and polysaccharide, a mixture thereof and polyvinyl pyrrolidone usable in the present invention have the following properties: (1) they are easily soluble in water, eliminate the need for being taken out from the tubular organ after surgery and disappears before thrombosis occurs; (2) they are utilized as a sweetener or as a vehicle or excipient for principal foods or pharmaceuticals and are highly safe in use.
- the monosaccharide and oligosaccharide are crystalline and melted on heating, so that they can be cast into a desired shape.
- Polysaccharide and polyvinyl pyrrolidone are the amorphous polymers which are not melted by heating, but they can be reduced to a viscous solution or a paste-like substance with water and can be formed into a desired shape by molding and drying or by coagulating in a non-aqueous solvent such as alcohol.
- the mixture of monosaccharide and polysaccharide, oligosaccharide and polysaccharide, and monosaccharide, oligosaccharide and polysaccharide have the following merits: (1) The frailness of monosaccharide and oligosaccharide and the mixture thereof due to their high crystallinity is compensated by the polymeric properties of polysaccharide. (2) Said mixtures necessarily containing a polysaccharide, when heated above the melting points of monosaccharide, oligosaccharide and mixtures thereof, are melted and turned into a syrup-like viscous substance even in the absence of water, and such viscous substance can be solidified by cooling, this process being reversible.
- Glucose and fructose are typical examples for hexose. They are admitted to be used as an injection medicine and no problem on safety arises when dissolved in blood in a blood vessel. Thus, they are recommended for use as most preferred monosaccharides in the present invention.
- the monosaccharide derivatives for example, saccharic acids such as gluconic acid formed by oxidizing glucose and sugar alcohols such as D-sorbitol and D-mannitol formed by reducing glucose, and xylitol formed by reducing xylose, etc., are also included in the scope of the monosaccharide in the present invention.
- saccharic acids such as gluconic acid formed by oxidizing glucose
- sugar alcohols such as D-sorbitol and D-mannitol formed by reducing glucose, and xylitol formed by reducing xylose, etc.
- D-sorbitol, D-mannitol and xylitol are preferable for use in the present invention as they are stable even when melted by heating, cause no browning reaction peculiar to the sugars and are pharmacologically accepted as a component of injection medicines.
- Oligosaccharides are divided into di- to decasaccharides according to the molecular number of monosaccharides produced from hydrolysis. Disaccharides such as maltose, lactose and sucrose and trisaccharides such as raffinose and melezitose are used as a food component and can be cited as preferred oligosaccharides with high safety for use in the present invention.
- Polysaccharides usable in the present invention are the nutritive polysaccharides such as starch, glycogen, dextran, pullulan, inulin, etc., and their derivatives such as hydroxyethyl starch.
- hydroxyethyl starch and dextran are commonly used as a blood bulking agent and preferred for use in the present invention as they are very high in safety when used as a support for blood vessels.
- the mixing ratios of the materials may be properly selected according to other conditions such as thickness, shape and size of the support to be made and the region of use thereof.
- the support in case of using a monosaccharide, an oligosaccharide or a mixture thereof as a starting material, since these saccharides can be melted by heating as mentioned above, there can be used the same techniques as generally employed for producing glass tubes or glass plates from molten glass, or may be molded into a desired shape such as tube, semicylinder, plate, etc.
- desired molding can be accomplished by forming a syrup-like substance with water, followed by casting and drying, or by coagulating such a syrup-like substance in a non-aqueous solvent.
- molding can be repeated by melting the once formed support by heating and re-molding it, and the support of a desired shape and size can be easily produced.
- the support molded from said materials without using water is usually hard and frail, so that care is needed for handling and storage thereof.
- a substance assured for high safety and having a plasticizing effect such as water, may be previously added in the material or may be left in the support when dried. If necessary, various kinds of pharmaceutical compounds may be also added similarly to said plasticizing substance.
- a substance which is sparingly soluble in water and causes no ill effect to the living body when mixed in body fluid may be blended in the support in the course of its molding or coated on the surface thereof.
- the support for anastomosing or connecting living organs in a living body can be shaped into a desired form such as tube, semicylinder, plate, etc., but the tubular form is most suited for practical use.
- the dimentional conditions such as the length, thickness, etc. of the support may be selected according to the ordinary skill of the art.
- Japanese pharmacopoeia glucose, fructose, D-sorbitol and xylitol were selected for use as monosaccharide and non Japanese pharmacopoeia hydroxyethyl starch (HES) and dextran 40 were selected for use as polysaccharide.
- the monosaccharide and the polysaccharide shown in Table 1 were mixed (50 parts by weight each) in a glass container.
- the inside atmosphere of the container was replaced with nitrogen and the mixture was gradually heated in an oil bath.
- the polysaccharide was also melted and the mixture was reduced into a syrup-like melt.
- an end of a glass tube was introduced into the syrup-like melt, then taken out and quickly stretched to form a tube having an outer diameter of about 4 mm and an inner diameter of about 2 mm.
- the tube was cut to a length of 10 mm and kept in a container having a desiccant placed therein.
- Silicone tubes were connected by using the supports obtained in Example 1, and then the various types of fluid shown in Table 2, each being maintained at 37.5° C., were circulated through the connected tubes at a flow rate of about 200 ml/min by using a roller pump (mfd. by Furue Science Co., Ltd.) The state of dissolution of the support was observed while determining the time required till the support was dissolved away.
- Example 2 the tubular support was dissolved gradually from the inside, and there took place no break of the support in the silicone tube nor obstruction of the tube in the course of the operation.
- the influece of humidity in the air on the tubular support could be lessened.
- the non-coated support was very hygroscopic and required care for its handling and storage, but the coated support had no stickiness on the surface even if left in the air.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP62-107125 | 1987-04-30 | ||
JP10712587 | 1987-04-30 | ||
JP63-33505 | 1988-02-16 | ||
JP63033505A JPS6425870A (en) | 1987-04-30 | 1988-02-16 | Support for anastomosis or bonding of living body |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US07187461 Continuation | 1988-04-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
US5064057A true US5064057A (en) | 1991-11-12 |
Family
ID=26372210
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US07/501,363 Expired - Fee Related US5064057A (en) | 1987-04-30 | 1990-03-30 | Support for anastomosing or connecting living organs |
Country Status (4)
Country | Link |
---|---|
US (1) | US5064057A (de) |
JP (1) | JPS6425870A (de) |
CH (1) | CH674806A5 (de) |
DE (1) | DE3814651A1 (de) |
Cited By (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5419760A (en) * | 1993-01-08 | 1995-05-30 | Pdt Systems, Inc. | Medicament dispensing stent for prevention of restenosis of a blood vessel |
US5527324A (en) * | 1994-09-07 | 1996-06-18 | Krantz; Kermit E. | Surgical stent |
US5549122A (en) * | 1989-07-26 | 1996-08-27 | Detweilwer; Mark B. | Methods of surgical mammalian vessel anastomosis |
US5551954A (en) * | 1991-10-04 | 1996-09-03 | Scimed Life Systems, Inc. | Biodegradable drug delivery vascular stent |
WO2000050013A1 (en) * | 1999-02-22 | 2000-08-31 | Quadrant Healthcare (Uk) Limited | Rapidly-soluble compositions |
US6184266B1 (en) | 1996-07-11 | 2001-02-06 | Scimed Life Systems, Inc. | Medical devices comprising cross-linked hydrogels having improved mechanical properties |
WO2008124638A1 (en) * | 2007-04-06 | 2008-10-16 | Dr, Kelley Cancer Foundation | Methods and apparatus for surgical anastomosis |
US8814025B2 (en) | 2011-09-15 | 2014-08-26 | Ethicon Endo-Surgery, Inc. | Fibrin pad matrix with suspended heat activated beads of adhesive |
US8899464B2 (en) | 2011-10-03 | 2014-12-02 | Ethicon Endo-Surgery, Inc. | Attachment of surgical staple buttress to cartridge |
US8985429B2 (en) | 2011-09-23 | 2015-03-24 | Ethicon Endo-Surgery, Inc. | Surgical stapling device with adjunct material application feature |
US8998060B2 (en) | 2011-09-13 | 2015-04-07 | Ethicon Endo-Surgery, Inc. | Resistive heated surgical staple cartridge with phase change sealant |
US8998059B2 (en) | 2011-08-01 | 2015-04-07 | Ethicon Endo-Surgery, Inc. | Adjunct therapy device having driver with cavity for hemostatic agent |
US9089326B2 (en) | 2011-10-07 | 2015-07-28 | Ethicon Endo-Surgery, Inc. | Dual staple cartridge for surgical stapler |
US9101359B2 (en) | 2011-09-13 | 2015-08-11 | Ethicon Endo-Surgery, Inc. | Surgical staple cartridge with self-dispensing staple buttress |
US9125649B2 (en) | 2011-09-15 | 2015-09-08 | Ethicon Endo-Surgery, Inc. | Surgical instrument with filled staple |
US9198644B2 (en) | 2011-09-22 | 2015-12-01 | Ethicon Endo-Surgery, Inc. | Anvil cartridge for surgical fastening device |
US9254180B2 (en) | 2011-09-15 | 2016-02-09 | Ethicon Endo-Surgery, Inc. | Surgical instrument with staple reinforcement clip |
US9393018B2 (en) | 2011-09-22 | 2016-07-19 | Ethicon Endo-Surgery, Inc. | Surgical staple assembly with hemostatic feature |
US9492170B2 (en) | 2011-08-10 | 2016-11-15 | Ethicon Endo-Surgery, Inc. | Device for applying adjunct in endoscopic procedure |
US9974543B2 (en) | 2013-12-06 | 2018-05-22 | W. L. Gore & Associates, Inc. | Anastomotic connectors |
US9999408B2 (en) | 2011-09-14 | 2018-06-19 | Ethicon Endo-Surgery, Inc. | Surgical instrument with fluid fillable buttress |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3155095A (en) * | 1961-02-07 | 1964-11-03 | Adolph M Brown | Anastomosis method and means |
US3683926A (en) * | 1970-07-09 | 1972-08-15 | Dainippon Pharmaceutical Co | Tube for connecting blood vessels |
US3975350A (en) * | 1972-08-02 | 1976-08-17 | Princeton Polymer Laboratories, Incorporated | Hydrophilic or hydrogel carrier systems such as coatings, body implants and other articles |
US4074366A (en) * | 1975-03-14 | 1978-02-21 | American Cyanamid Company | Poly(N-acetyl-D-glucosamine) products |
EP0154103A1 (de) * | 1984-02-22 | 1985-09-11 | Antonio Di Mezza | Physiologisch absorbierbare Prothese für die Anastomose von Gefässen und Kanälen von Mensch und Tier |
EP0194192A1 (de) * | 1985-02-22 | 1986-09-10 | Ethnor | Absorbierbares zusammengesetztes chirurgisches Material, Verfahren zur Herstellung, resorbierbare Prothese aus solchem Material und Verwendung einer solchen Prothese |
US4705039A (en) * | 1984-07-28 | 1987-11-10 | Takasago Medical Industry, Co., Ltd. | Subsidiary device for suturing an intestine |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3969498A (en) * | 1973-09-13 | 1976-07-13 | University Of The Pacific | Dressing and method for treating a wound |
GB1594389A (en) * | 1977-06-03 | 1981-07-30 | Max Planck Gesellschaft | Dressing material for wounds |
GB2031441B (en) * | 1978-08-24 | 1982-11-17 | Barnes C | Polypyrrolidone iodine complex |
GB2041377B (en) * | 1979-01-22 | 1983-09-28 | Woodroof Lab Inc | Bio compatible and blood compatible materials and methods |
DE2947985A1 (de) * | 1979-11-28 | 1981-09-17 | Vsesojuznyj naučno-issledovatel'skij i ispytatel'nyj institut medicinskoj techniki, Moskva | Biodestruktiver stoff fuer verbindungselemente fuer knochengewebe |
GB2158724B (en) * | 1983-12-01 | 1987-02-11 | Vni Ispytatelny Inst | Material of connective elements for soft tissues and internal organs |
-
1988
- 1988-02-16 JP JP63033505A patent/JPS6425870A/ja active Pending
- 1988-04-25 CH CH1532/88A patent/CH674806A5/de not_active IP Right Cessation
- 1988-04-29 DE DE3814651A patent/DE3814651A1/de not_active Withdrawn
-
1990
- 1990-03-30 US US07/501,363 patent/US5064057A/en not_active Expired - Fee Related
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3155095A (en) * | 1961-02-07 | 1964-11-03 | Adolph M Brown | Anastomosis method and means |
US3683926A (en) * | 1970-07-09 | 1972-08-15 | Dainippon Pharmaceutical Co | Tube for connecting blood vessels |
US3975350A (en) * | 1972-08-02 | 1976-08-17 | Princeton Polymer Laboratories, Incorporated | Hydrophilic or hydrogel carrier systems such as coatings, body implants and other articles |
US4074366A (en) * | 1975-03-14 | 1978-02-21 | American Cyanamid Company | Poly(N-acetyl-D-glucosamine) products |
EP0154103A1 (de) * | 1984-02-22 | 1985-09-11 | Antonio Di Mezza | Physiologisch absorbierbare Prothese für die Anastomose von Gefässen und Kanälen von Mensch und Tier |
US4705039A (en) * | 1984-07-28 | 1987-11-10 | Takasago Medical Industry, Co., Ltd. | Subsidiary device for suturing an intestine |
EP0194192A1 (de) * | 1985-02-22 | 1986-09-10 | Ethnor | Absorbierbares zusammengesetztes chirurgisches Material, Verfahren zur Herstellung, resorbierbare Prothese aus solchem Material und Verwendung einer solchen Prothese |
Cited By (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5549122A (en) * | 1989-07-26 | 1996-08-27 | Detweilwer; Mark B. | Methods of surgical mammalian vessel anastomosis |
US5551954A (en) * | 1991-10-04 | 1996-09-03 | Scimed Life Systems, Inc. | Biodegradable drug delivery vascular stent |
US5419760A (en) * | 1993-01-08 | 1995-05-30 | Pdt Systems, Inc. | Medicament dispensing stent for prevention of restenosis of a blood vessel |
US5527324A (en) * | 1994-09-07 | 1996-06-18 | Krantz; Kermit E. | Surgical stent |
US6184266B1 (en) | 1996-07-11 | 2001-02-06 | Scimed Life Systems, Inc. | Medical devices comprising cross-linked hydrogels having improved mechanical properties |
US6387978B2 (en) | 1996-07-11 | 2002-05-14 | Boston Scientific Corporation | Medical devices comprising ionically and non-ionically crosslinked polymer hydrogels having improved mechanical properties |
WO2000050013A1 (en) * | 1999-02-22 | 2000-08-31 | Quadrant Healthcare (Uk) Limited | Rapidly-soluble compositions |
US20080255650A1 (en) * | 2007-04-06 | 2008-10-16 | Jill Kelley | Methods and apparatus for surgical anastomosis |
WO2008124638A1 (en) * | 2007-04-06 | 2008-10-16 | Dr, Kelley Cancer Foundation | Methods and apparatus for surgical anastomosis |
US8894699B2 (en) * | 2007-04-06 | 2014-11-25 | Dr. Kelley Cancer Foundation | Methods and apparatus for surgical anastomosis |
US8998059B2 (en) | 2011-08-01 | 2015-04-07 | Ethicon Endo-Surgery, Inc. | Adjunct therapy device having driver with cavity for hemostatic agent |
US9492170B2 (en) | 2011-08-10 | 2016-11-15 | Ethicon Endo-Surgery, Inc. | Device for applying adjunct in endoscopic procedure |
US8998060B2 (en) | 2011-09-13 | 2015-04-07 | Ethicon Endo-Surgery, Inc. | Resistive heated surgical staple cartridge with phase change sealant |
US9101359B2 (en) | 2011-09-13 | 2015-08-11 | Ethicon Endo-Surgery, Inc. | Surgical staple cartridge with self-dispensing staple buttress |
US9999408B2 (en) | 2011-09-14 | 2018-06-19 | Ethicon Endo-Surgery, Inc. | Surgical instrument with fluid fillable buttress |
US8814025B2 (en) | 2011-09-15 | 2014-08-26 | Ethicon Endo-Surgery, Inc. | Fibrin pad matrix with suspended heat activated beads of adhesive |
US9254180B2 (en) | 2011-09-15 | 2016-02-09 | Ethicon Endo-Surgery, Inc. | Surgical instrument with staple reinforcement clip |
US9125649B2 (en) | 2011-09-15 | 2015-09-08 | Ethicon Endo-Surgery, Inc. | Surgical instrument with filled staple |
US9198644B2 (en) | 2011-09-22 | 2015-12-01 | Ethicon Endo-Surgery, Inc. | Anvil cartridge for surgical fastening device |
US9393018B2 (en) | 2011-09-22 | 2016-07-19 | Ethicon Endo-Surgery, Inc. | Surgical staple assembly with hemostatic feature |
US8985429B2 (en) | 2011-09-23 | 2015-03-24 | Ethicon Endo-Surgery, Inc. | Surgical stapling device with adjunct material application feature |
US8899464B2 (en) | 2011-10-03 | 2014-12-02 | Ethicon Endo-Surgery, Inc. | Attachment of surgical staple buttress to cartridge |
US9089326B2 (en) | 2011-10-07 | 2015-07-28 | Ethicon Endo-Surgery, Inc. | Dual staple cartridge for surgical stapler |
US9974543B2 (en) | 2013-12-06 | 2018-05-22 | W. L. Gore & Associates, Inc. | Anastomotic connectors |
Also Published As
Publication number | Publication date |
---|---|
JPS6425870A (en) | 1989-01-27 |
CH674806A5 (de) | 1990-07-31 |
DE3814651A1 (de) | 1988-11-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: AJINOMOTO CO., INC., A JOINT-STOCK COMPANY OF JAPA Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNORS:IWATSUKI, MAKOTO;HAYASHI, TOSHIO;REEL/FRAME:005829/0178;SIGNING DATES FROM 19880531 TO 19880603 |
|
FEPP | Fee payment procedure |
Free format text: PAYOR NUMBER ASSIGNED (ORIGINAL EVENT CODE: ASPN); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY |
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REMI | Maintenance fee reminder mailed | ||
LAPS | Lapse for failure to pay maintenance fees | ||
FP | Lapsed due to failure to pay maintenance fee |
Effective date: 19961115 |
|
STCH | Information on status: patent discontinuation |
Free format text: PATENT EXPIRED DUE TO NONPAYMENT OF MAINTENANCE FEES UNDER 37 CFR 1.362 |