US4509861A - Method of mixing one substance with another substance - Google Patents

Method of mixing one substance with another substance Download PDF

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Publication number
US4509861A
US4509861A US06/461,547 US46154783A US4509861A US 4509861 A US4509861 A US 4509861A US 46154783 A US46154783 A US 46154783A US 4509861 A US4509861 A US 4509861A
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United States
Prior art keywords
substance
port
way valve
pump means
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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US06/461,547
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English (en)
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Goran Sjonell
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Individual
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Individual
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/50—Movable or transportable mixing devices or plants
    • B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
    • B01F33/5011—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/50—Movable or transportable mixing devices or plants
    • B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
    • B01F33/5011—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held
    • B01F33/50111—Small portable bottles, flasks, vials, e.g. with means for mixing ingredients or for homogenizing their content, e.g. by hand shaking
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/712—Feed mechanisms for feeding fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/7176—Feed mechanisms characterised by the means for feeding the components to the mixer using pumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/718—Feed mechanisms characterised by the means for feeding the components to the mixer using vacuum, under pressure in a closed receptacle or circuit system
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/71805—Feed mechanisms characterised by the means for feeding the components to the mixer using valves, gates, orifices or openings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/71805—Feed mechanisms characterised by the means for feeding the components to the mixer using valves, gates, orifices or openings
    • B01F35/718051—Feed mechanisms characterised by the means for feeding the components to the mixer using valves, gates, orifices or openings being adjustable
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/75—Discharge mechanisms
    • B01F35/754—Discharge mechanisms characterised by the means for discharging the components from the mixer
    • B01F35/75465—Discharge mechanisms characterised by the means for discharging the components from the mixer using suction, vacuum, e.g. with a pipette
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2013—Piercing means having two piercing ends

Definitions

  • This invention relates to a method of mixing one substance, for example cytostatica, with another substance, for example sterile water.
  • substances which are used in medical care, are transported and stored in ampules, which are sealingly closed with a rubber cover or membrane.
  • Cytostatica are used in medical care for the treatment of patients suffering from cancer, either by intravenous injection or from a drop bottle. Cytostatica are delivered in powder state in an ampule of the aforesaid kind and must be mixed, prior to their administration, with a liquid, for example sterile water, alcohol, physical saline solution or some other solution. The liquid, too, is delivered in an ampule of the kind referred to above. At present, the two substances are intermixed in such a manner, that the liquid by means of the hypodermic syringe to be used for the injection is sucked from the ampule up into the syringe and is delivered to the dry ampule, viz. the ampule containing the cytostatica.
  • the cytostatica content is mixed with liquid to the desired concentration, and the mixture thereafter is sucked into the syringe.
  • the syringe Prior to the injection, the syringe is emptied of air possibly included therein. This emptying normally is carried out in the established manner by holding the syringe in vertical position, with the hypodermic needle pointing upward, and pressing the plunger inward until liquid can be observed in the needle point.
  • Cytostatica a.o. have proved toxic and to negatively affect healthy persons.
  • the personnel handling this substance are exposed to great risks of inhaling such cancerogenous substances or by direct contact to be infected with them.
  • the present invention has the object to eliminate the risks of contaminating the surrounding and infecting the personnel, who handle these substances when they are mixing toxic substances e.g. of the aforesaid type for their subsequent use, for example injection.
  • FIG. 1 in a very schematic manner shows the equipment according to the invention for carrying out the method
  • FIG. 2 also in a very schematic manner shows the same equipment, but with the ampules seen in a lateral view, and
  • FIG. 3 shows a slightly different equipment.
  • FIG. 1 shows two ampules 1 and 2 whereof one, for example 1, contains cytostatica, and the second ampule contains sterile water.
  • These ampules are positioned by press fit in depressions provided, for example, in a frigolite plate and are fixed therein.
  • a multi-way valve 4 is attached, for example by press fit, in a depression in the plate, or it is secured therein by glueing.
  • the multi-way valve 4 comprises four ports whereof a first one 5 is connected by a hose 6 to a hypodermic needle 7, which is pierced down into the ampule 1 through a rubber closure 8 sealing the ampule 1 hermetically.
  • a second port 9 is connected via a hose 10 to the second ampule 2, in that a hypodermic needle 11 attached to the other end of the hose 10 is pierced down, in the same manner as the needle 7, into the ampule 2 through a rubber closure 12 sealing hermetically said ampule 2.
  • a hose 13 is provided at each end with a needle 14 and, respectively, 15 similar to a hypodermic needle, interconnects the interior of the two ampules, in that the needles 14 and 15 are pierced through the rubber closures 8 and, respectively, 12.
  • the hose 13 is provided to allow the equalization of pressures within the ampules 1 and 2 during the transfer of the liquid in ampule 2 to the ampule 1.
  • the multi-way valve 4 further comprises a third port 16, into which the opening of a hypodermic syringe 17 can be sealingly introduced.
  • the method of mixing the cytostatic powder in the ampule 1 with the sterile water in ampule 2 is as follows: A certain amount of air is supplied into the system which is assembled of the hoses and ampules, through the hose 10 by means of the hypodermic syringe 17, which with its opening has been attached sealingly in the port 16. The amount of air is adjusted, for example, by adjusting the handle 18 on the multi-way valve. This air supply has the object to facilitate the subsequent sucking of water out of the ampule 2 via the hypodermic needle 11, hose 10, and port 9 into the syringe 17. The handle 18 now is adjusted so that the port 5 opens, while the ports 9 and 19 are closed, and the water is injected from the syringe into the ampule 1.
  • the handle again is adjusted so that the port 9 opens (the ports 5 and 19 are closed), and a new batch of water is sucked into the syringe 17.
  • the handle 18 is again adjusted so as to open the port 5, and said new batch is injected into the ampule 1. This procedure is repeated until all liquid has been transferred from the ampule 2 to the ampule 1. The resulting mixture in ampule 1 then can be sucked into the syringe 17.
  • the multi-way valve 4 is provided with a fourth port 19, which by a hose 20 is connected directly to an infusion unit 21.
  • the mixture contained in the syringe 17 can be supplied directly to the infusion unit 21 via the hose 20, in that the handle 18 is adjusted so that the ports 5 and 9 are closed and the port 10 opens.
  • no gas or liquid could penetrate out of the equipment, viz. syringe, hoses and ampules.
  • the opening thereof preferably can be inserted into a sealing cap 22 (FIG. 1), which closes the opening and is attached in a suitable manner to the plate 3.
  • a sealing cap 22 FIG. 1
  • the sealing cap which still is attached on the syringe 17, is broken off in a simple way from the plate 3. Neither during this entire procedure of syringe filling with the mixture there is any risk of liquid or gas penetrating out of the equipment described.
  • the infusion unit 21 is deleted and the hose 20 is provided with a cannula.
  • the liquid is then injected by means of the syringe 17 or the bellows 23, described later on.
  • a pump means 23 can be used, which then is connected to the third port 16 of the multi-way valve 4.
  • the pump means 23 in principle may consist of a self-expanding bellows, for example of plastic, which preferably is attached on the multi-way valve 4 or on the plate 3 in vertically upright position.
  • the two substances here are mixed in the same way as in the case of the syringe 17 being used.
  • the pump means, viz. the bellows 23 is compressed and thereafter at its expansion sucks up liquid in the ampule 2 via the hypodermic needle 11, hose 10 and port 9. Due to the adjusting of the handle 18 and the compression of the bellows, the liquid is transferred to the ampule 1, in which the mixing takes place.
  • the bellows is permitted to expand, whereby the mixture is sucked up into the ampule 1.
  • This condition corresponds to the syringe 17 in filled state, with the difference, however, that the utilization of a bellows does not imply the risk which may arise at the utilization of a syringe, viz. that the syringe unintentionally may loosen from the multi-way valve 4 and thereby with its content contaminate the surrounding.
  • the hose 20 for example, can be provided with a connection (not shown), at which a hypodermic syringe to be used can be attached. The syringe then can be filled by sucking up with the same the mixture from the bellows.
  • the plate with hoses and valve and the sealing cap can be delivered in sets, with recesses for ampules of varying size.
  • the hypodermic needles 7,11 and the needles 14,15 may have a design other than that shown. Hypodermic needles in this connection are to be understood to be tubes pointed at one end and easy to penetrate through the rubber closures of the ampules.
US06/461,547 1982-01-29 1983-01-27 Method of mixing one substance with another substance Expired - Fee Related US4509861A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8200504A SE427245B (sv) 1982-01-29 1982-01-29 Forfarande for blandning av ett emne, t ex cytostatika, forvarat i en med gummiforslutning eller motsvarande forsedd ampull, med ett annat emne, t ex sterilt vatten, likasa forvarat i en med gummiforslutning eller motsv

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US4509861A true US4509861A (en) 1985-04-09

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US (1) US4509861A (sv)
EP (1) EP0085663B1 (sv)
JP (1) JPS58169452A (sv)
AR (1) AR229636A1 (sv)
AT (1) ATE23795T1 (sv)
AU (1) AU1090883A (sv)
BR (1) BR8300418A (sv)
CA (1) CA1204731A (sv)
DE (1) DE3367847D1 (sv)
DK (1) DK33683A (sv)
ES (1) ES278852Y (sv)
FI (1) FI830285L (sv)
NO (1) NO830293L (sv)
SE (1) SE427245B (sv)

Cited By (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4600040A (en) * 1983-03-21 1986-07-15 Naeslund Jan Ingemar Arrangement in apparatus for preparing solutions from harmful substances
US4787890A (en) * 1986-01-10 1988-11-29 Fresenius Ag Feeding system for enteral feeding
US4820269A (en) * 1983-03-07 1989-04-11 Vanderbilt University Mixer apparatus for controlling intravenous drug infusion
US4888004A (en) * 1985-12-05 1989-12-19 Hemascience Laboratories, Inc. Method and apparatus for purging tubing network of blood processing system
US5490848A (en) * 1991-01-29 1996-02-13 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration System for creating on site, remote from a sterile environment, parenteral solutions
EP0757096A2 (en) * 1995-07-29 1997-02-05 Siemens Plc Improvements in or relating to aqueous sample testing apparatus
US5658248A (en) * 1995-08-04 1997-08-19 Localmed, Inc. Double-blind infusion device and method
US6402364B1 (en) * 1999-04-02 2002-06-11 L'oreal Portable dispenser for packaging and dispensing colored cosmetics
US20030072212A1 (en) * 1997-10-24 2003-04-17 Wood Anthony B. Diffuser/emulsifier
US20030199832A1 (en) * 2002-04-22 2003-10-23 Juergen Greiner-Perth Dosing device with at least two media chambers
US20050047270A1 (en) * 1997-10-24 2005-03-03 Wood Anthony B. System and method for therapeutic application of dissolved oxygen
US20050137532A1 (en) * 2003-12-18 2005-06-23 Rolla Jose S. Unit to administer injectable medication manually or automatically
US20070210180A1 (en) * 1997-10-24 2007-09-13 Microdiffusion, Inc. System and method for irrigating with aerated water
WO2007101786A1 (en) * 2006-03-06 2007-09-13 Novo Nordisk A/S A drug delivery device with a valve
US20080065088A1 (en) * 2006-09-07 2008-03-13 Wyeth Bone Cement Mixing Systems and Related Methods
US20080146679A1 (en) * 2006-10-25 2008-06-19 Revalesio Corporation Methods of therapeutic treatment of eyes and other human tissues using an oxygen-enriched solution
US20080281001A1 (en) * 2006-10-25 2008-11-13 Revalesio Corporation Mixing device
CN100435866C (zh) * 2004-04-18 2008-11-26 吕海洋 医用配药器
US20090043282A1 (en) * 2005-04-29 2009-02-12 Wyeth Drug Delivery Devices and Related Components, Systems and Methods
US20090227018A1 (en) * 2007-10-25 2009-09-10 Revalesio Corporation Compositions and methods for modulating cellular membrane-mediated intracellular signal transduction
US20100297193A1 (en) * 2006-10-25 2010-11-25 Revalesio Corporation Methods of therapeutic treatment of eyes
US20100310665A1 (en) * 2007-10-25 2010-12-09 Revalesio Corporation Bacteriostatic or bacteriocidal compositions and methods
US7887698B2 (en) 1997-10-24 2011-02-15 Revalesio Corporation Diffuser/emulsifier for aquaculture applications
CN101804225B (zh) * 2010-02-05 2011-10-26 深圳市卫邦科技有限公司 自动输液配药设备及自动输液配药方法
US20120029464A1 (en) * 2008-10-15 2012-02-02 Novo Nordisk Healthcare Ag System for reconstitution of a powdered drug
US8445546B2 (en) 2006-10-25 2013-05-21 Revalesio Corporation Electrokinetically-altered fluids comprising charge-stabilized gas-containing nanostructures
US8609148B2 (en) 2006-10-25 2013-12-17 Revalesio Corporation Methods of therapeutic treatment of eyes
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US8815292B2 (en) 2009-04-27 2014-08-26 Revalesio Corporation Compositions and methods for treating insulin resistance and diabetes mellitus
US8980325B2 (en) 2008-05-01 2015-03-17 Revalesio Corporation Compositions and methods for treating digestive disorders
CN104997633A (zh) * 2015-07-06 2015-10-28 中国人民解放军第三军医大学第二附属医院 自动化配药的混液装置
US9198929B2 (en) 2010-05-07 2015-12-01 Revalesio Corporation Compositions and methods for enhancing physiological performance and recovery time
US9492404B2 (en) 2010-08-12 2016-11-15 Revalesio Corporation Compositions and methods for treatment of taupathy
US9523090B2 (en) 2007-10-25 2016-12-20 Revalesio Corporation Compositions and methods for treating inflammation
US9745567B2 (en) 2008-04-28 2017-08-29 Revalesio Corporation Compositions and methods for treating multiple sclerosis
US10125359B2 (en) 2007-10-25 2018-11-13 Revalesio Corporation Compositions and methods for treating inflammation

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* Cited by examiner, † Cited by third party
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DE3315031C2 (de) * 1983-04-26 1985-09-05 Pfrimmer-Viggo GmbH & Co KG, 8520 Erlangen Verfahren und Vorrichtung zum Herstellen von Gemischen pharmazeutischer Flüssigkeiten
DK154884A (da) * 1984-03-13 1985-09-14 Medesign A S Hjaelpeapparat til klargoerelse af injicerbare medikamenter
DE4122221A1 (de) * 1991-07-04 1993-03-18 Axel Von Brand Transfer- und entnahmespike
DE4408498C2 (de) * 1993-11-16 1997-06-12 Christian Eichler Umfülleinrichtung für die Medizin und die Pharmazie
CN104287966B (zh) 2009-05-04 2017-03-15 瓦莱里塔斯公司 流体传输装置
FR2969507B1 (fr) 2010-12-24 2014-07-11 Eveon Dispositif pour melanger deux constituants
CN105125404B (zh) * 2015-06-17 2018-08-31 苏州艾隆科技股份有限公司 半自动药物冲配机

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2432004A (en) * 1943-06-26 1947-12-02 Gray Mills Corp Coolant pump
US2842124A (en) * 1956-12-10 1958-07-08 Joseph M James Blood transfusion system
US3190619A (en) * 1963-05-27 1965-06-22 Union Carbide Corp Fluid mixing container assembly
US3223485A (en) * 1962-09-07 1965-12-14 Technicon Instr Apparatus for treatment of solids for analysis
US3385480A (en) * 1967-06-15 1968-05-28 Walter H Helling Liquid mixing and dispensing apparatus
US3561733A (en) * 1968-07-30 1971-02-09 Westvaco Corp Vacuum slurry system
US3572338A (en) * 1968-02-27 1971-03-23 Leo E Murray Jr Mixing and delivery apparatus
US4235552A (en) * 1979-04-16 1980-11-25 3U Partners Fluid mixing system
US4237880A (en) * 1979-02-28 1980-12-09 Abbott Laboratories Equipment sets for the sequential administration of medical liquids at dual flow rates employing a combined air barrier and liquid sequencing valve controlled by a common flexible membrane
US4253501A (en) * 1979-11-09 1981-03-03 Ims Limited Transfer system
US4253942A (en) * 1978-07-14 1981-03-03 Gesellschaft Zur Forderung Der Forschung An Der Eidgenossischen Technischen Hochschule Apparatus for the separation of mixtures of particulate solids of different density
US4340308A (en) * 1980-08-01 1982-07-20 Tharp Billy J Method and apparatus for producing fluidized lime
US4407431A (en) * 1981-03-04 1983-10-04 Hutter Iii Charles G System for dispensing curable compositions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2584397A (en) * 1945-10-03 1952-02-05 Louis K Pitman Apparatus for transferring liquid from one container to another
FR1337376A (fr) * 1962-07-30 1963-09-13 Debat Lab Dispositif permettant l'obtention extemporanée de préparations pharmaceutiques injectables ou buvables
US3451393A (en) * 1966-02-07 1969-06-24 Stanley J Sarnoff Automatic infusion device

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2432004A (en) * 1943-06-26 1947-12-02 Gray Mills Corp Coolant pump
US2842124A (en) * 1956-12-10 1958-07-08 Joseph M James Blood transfusion system
US3223485A (en) * 1962-09-07 1965-12-14 Technicon Instr Apparatus for treatment of solids for analysis
US3190619A (en) * 1963-05-27 1965-06-22 Union Carbide Corp Fluid mixing container assembly
US3385480A (en) * 1967-06-15 1968-05-28 Walter H Helling Liquid mixing and dispensing apparatus
US3572338A (en) * 1968-02-27 1971-03-23 Leo E Murray Jr Mixing and delivery apparatus
US3561733A (en) * 1968-07-30 1971-02-09 Westvaco Corp Vacuum slurry system
US4253942A (en) * 1978-07-14 1981-03-03 Gesellschaft Zur Forderung Der Forschung An Der Eidgenossischen Technischen Hochschule Apparatus for the separation of mixtures of particulate solids of different density
US4237880A (en) * 1979-02-28 1980-12-09 Abbott Laboratories Equipment sets for the sequential administration of medical liquids at dual flow rates employing a combined air barrier and liquid sequencing valve controlled by a common flexible membrane
US4235552A (en) * 1979-04-16 1980-11-25 3U Partners Fluid mixing system
US4253501A (en) * 1979-11-09 1981-03-03 Ims Limited Transfer system
US4340308A (en) * 1980-08-01 1982-07-20 Tharp Billy J Method and apparatus for producing fluidized lime
US4407431A (en) * 1981-03-04 1983-10-04 Hutter Iii Charles G System for dispensing curable compositions

Cited By (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4820269A (en) * 1983-03-07 1989-04-11 Vanderbilt University Mixer apparatus for controlling intravenous drug infusion
US4600040A (en) * 1983-03-21 1986-07-15 Naeslund Jan Ingemar Arrangement in apparatus for preparing solutions from harmful substances
US4888004A (en) * 1985-12-05 1989-12-19 Hemascience Laboratories, Inc. Method and apparatus for purging tubing network of blood processing system
US4787890A (en) * 1986-01-10 1988-11-29 Fresenius Ag Feeding system for enteral feeding
US5490848A (en) * 1991-01-29 1996-02-13 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration System for creating on site, remote from a sterile environment, parenteral solutions
EP0757096A2 (en) * 1995-07-29 1997-02-05 Siemens Plc Improvements in or relating to aqueous sample testing apparatus
EP0757096A3 (en) * 1995-07-29 1997-03-05 Siemens Plc Improvements in or relating to aqueous sample testing apparatus
US5801052A (en) * 1995-07-29 1998-09-01 Siemens Plc Aqueous sample testing apparatus
US5658248A (en) * 1995-08-04 1997-08-19 Localmed, Inc. Double-blind infusion device and method
US20050047270A1 (en) * 1997-10-24 2005-03-03 Wood Anthony B. System and method for therapeutic application of dissolved oxygen
US7887698B2 (en) 1997-10-24 2011-02-15 Revalesio Corporation Diffuser/emulsifier for aquaculture applications
US7654728B2 (en) 1997-10-24 2010-02-02 Revalesio Corporation System and method for therapeutic application of dissolved oxygen
US7770814B2 (en) 1997-10-24 2010-08-10 Revalesio Corporation System and method for irrigating with aerated water
US7806584B2 (en) 1997-10-24 2010-10-05 Revalesio Corporation Diffuser/emulsifier
US20030072212A1 (en) * 1997-10-24 2003-04-17 Wood Anthony B. Diffuser/emulsifier
US20070210180A1 (en) * 1997-10-24 2007-09-13 Microdiffusion, Inc. System and method for irrigating with aerated water
US8349191B2 (en) 1997-10-24 2013-01-08 Revalesio Corporation Diffuser/emulsifier for aquaculture applications
US9034195B2 (en) 1997-10-24 2015-05-19 Revalesio Corporation Diffuser/emulsifier for aquaculture applications
US6402364B1 (en) * 1999-04-02 2002-06-11 L'oreal Portable dispenser for packaging and dispensing colored cosmetics
EP1356870A3 (de) * 2002-04-22 2005-09-21 Ing. Erich Pfeiffer GmbH Dosiervorrichtung mit wenigstens zwei Medienräumen
US20030199832A1 (en) * 2002-04-22 2003-10-23 Juergen Greiner-Perth Dosing device with at least two media chambers
US20050137532A1 (en) * 2003-12-18 2005-06-23 Rolla Jose S. Unit to administer injectable medication manually or automatically
CN100435866C (zh) * 2004-04-18 2008-11-26 吕海洋 医用配药器
US20090043282A1 (en) * 2005-04-29 2009-02-12 Wyeth Drug Delivery Devices and Related Components, Systems and Methods
WO2007101786A1 (en) * 2006-03-06 2007-09-13 Novo Nordisk A/S A drug delivery device with a valve
US20080065088A1 (en) * 2006-09-07 2008-03-13 Wyeth Bone Cement Mixing Systems and Related Methods
US20100297193A1 (en) * 2006-10-25 2010-11-25 Revalesio Corporation Methods of therapeutic treatment of eyes
US8784898B2 (en) 2006-10-25 2014-07-22 Revalesio Corporation Methods of wound care and treatment
US7832920B2 (en) 2006-10-25 2010-11-16 Revalesio Corporation Mixing device for creating an output mixture by mixing a first material and a second material
US9512398B2 (en) 2006-10-25 2016-12-06 Revalesio Corporation Ionic aqueous solutions comprising charge-stabilized oxygen-containing nanobubbles
US9511333B2 (en) 2006-10-25 2016-12-06 Revalesio Corporation Ionic aqueous solutions comprising charge-stabilized oxygen-containing nanobubbles
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US20080146679A1 (en) * 2006-10-25 2008-06-19 Revalesio Corporation Methods of therapeutic treatment of eyes and other human tissues using an oxygen-enriched solution
US9004743B2 (en) 2006-10-25 2015-04-14 Revalesio Corporation Mixing device for creating an output mixture by mixing a first material and a second material
US20080281001A1 (en) * 2006-10-25 2008-11-13 Revalesio Corporation Mixing device
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US20120029464A1 (en) * 2008-10-15 2012-02-02 Novo Nordisk Healthcare Ag System for reconstitution of a powdered drug
US8790328B2 (en) * 2008-10-15 2014-07-29 Novo Nordisk Healthcare A/G System for reconstitution of a powdered drug
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CN101804225B (zh) * 2010-02-05 2011-10-26 深圳市卫邦科技有限公司 自动输液配药设备及自动输液配药方法
US9198929B2 (en) 2010-05-07 2015-12-01 Revalesio Corporation Compositions and methods for enhancing physiological performance and recovery time
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CN104997633A (zh) * 2015-07-06 2015-10-28 中国人民解放军第三军医大学第二附属医院 自动化配药的混液装置

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EP0085663A3 (en) 1984-09-05
DK33683D0 (da) 1983-01-28
ES278852Y (es) 1985-03-01
SE427245B (sv) 1983-03-21
AU1090883A (en) 1983-08-04
BR8300418A (pt) 1983-11-01
JPS58169452A (ja) 1983-10-05
DK33683A (da) 1983-07-30
AR229636A1 (es) 1983-09-30
EP0085663B1 (en) 1986-11-26
ATE23795T1 (de) 1986-12-15
CA1204731A (en) 1986-05-20
FI830285A0 (fi) 1983-01-27
FI830285L (fi) 1983-07-30
ES278852U (es) 1984-08-01
DE3367847D1 (en) 1987-01-15
NO830293L (no) 1983-08-01
EP0085663A2 (en) 1983-08-10

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