US3451393A - Automatic infusion device - Google Patents

Automatic infusion device Download PDF

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Publication number
US3451393A
US3451393A US3451393DA US3451393A US 3451393 A US3451393 A US 3451393A US 3451393D A US3451393D A US 3451393DA US 3451393 A US3451393 A US 3451393A
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Prior art keywords
cartridge
barrel
end
infusion device
diluent
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Expired - Lifetime
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Stanley J Sarnoff
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Stanley J Sarnoff
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/145Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons

Description

June 1969 s. J. SARNOFF AUTOMATIC INFUSION DEVICE f f 3 m 0 f W m 0 I a mx QR 5 c w m QQ 3. 9 9 A4 8 ///V \H\ mm Q w 7. Wm M QM Q m H ATTORNEY June 24, 1969 1 5, s o 3,451,393

AUTOMATIC INFUS ION DEVICE Filed Feb. 7. 1966 Sheet 2 of 3 u: 0 N3 g E Q, Q m :3 is

I'll 1 1' HW I! M I NVENT OR Slan/ey J. Sarnaff ATTORNEY 5 June 24, 1969 5. J. SARNOFF 3,451,393

AUTOMA'I IC INFUS ION DEVICE Filed Feb. 7. 1966 Sheet 3 of 3 FIG. 5

INVENTOR Slam/ e y J. Sarnoff ATTORNEYS United States Patent 3,451,393 AUTOMATIC INFUSION DEVICE Stanley J. Sarnoff, 7507 Hampden Lane, Bethesda, Md. 20014 Filed Feb. 7, 1966, Ser. No. 525,399 Int. Cl. A61m /14 US. Cl. 128-214 11 Claims ABSTRACT OF THE DISCLOSURE An automatic infusion device comprises a pair of cylinders with a medication in one cylinder and a diluent in the other, said cylinders each containing at one end thereof a piston under spring pressure to move toward the other end of the piston, the cylinders at the other end having an intercommunicating duct to enable transfer of contents from one cylinder to the other. A valved branch conduit having a hypodermic needle at the end thereof enables the commingled materials to be ejected from the needle.

This invention relates to an automatic infusion device. In particular, it relates to an infusion device which can be utilized to administer a medicament to a patient with a minimum of attendance and under universal conditions.

There are circumstances when a large number of individuals are exposed to conditions which require the im mediate administration of large dosages of a medicament over an extended period of time, as one-half hour. This administration may be necessitated by reason of inhalation of poisonous crop control insecticides, or other poisonous gases, the latter perhaps occurring on a battlefield. This medication may have to be administered to a .large number of patients with few medical or other qualified personnel to administer the same.

It is an object of this invention to provide an automatic infusion device, the medicament from which can be administered to a patient, under pressure, but with fixed means, tailored in accordance with the tolerance of a patient and the medicament employed, to restrict the maximum rate of injection of the medication into the patient.

It is another object of this invention to provide an automatic infusion device, the medicament from which can be quickly administered to a patient and which may then be left unattended until the infusion is completed.

It is a further object of the invention to provide such a device which needs no pendant support and which device may be laid on the ground alongside of a patient or on the body of a patient.

Another object of the invention is to provide a twopart automatic infusion device, one of which may contain a dry powdered medication or a liquid medication, and the other a diluent for that powder or liquid, with means to force the diluent, under pressure, into the part containing the powder or liquid in order to ensure turbulent and effective mixing or dissolving of the powder in the diluent, or mixing of the diluent and liquid.

Other objects of the invention will become apparent after a consideration of the following specification, when taken in conjunction with the accompanying drawing, in which:

FIG. 1 is a perspective view of the infusion device, the

. cover being displaced, for greater clarity in viewing two barrels within a casing, the infusion device being in cocked position ready for administration of the medicament;

FIG. 2 is a perspective view of the casing and its contents with the diluent from a first barrel of the device forced into admixture with the medicament in the second barrel;

FIG. 3 is a perspective view of the casing and its contents, showing the medicament as it is being forced out of the second barrel and through a hypodermic needle, also forming part of the device;

FIG. 4 is a longitudinal cross-sectional view through the two barrels of the device, and showing additional appurtenant parts;

FIG. 5 is an enlarged cross-sectional detail of one end of a barrel; and

FIG. 6 is a view of a single barrel automatic infusion device with a predetermined restricted orifice in the feed line bet-ween the barrel and the needle.

For a better understanding of the invention, attention is directed to the following detailed description.

The infusion device comprises, in general, a casing 10 and its cover 12, the casing having a vertical partition wall 14 therein dividing the easing into two compartments. In one of the compartments is a first barrel 16 containing a cartridge 18 with a diluent 20 therein and in the other is a second barrel 22 containing medication, here shown in the form of a powder 24 within a cartridge 26. Joining the two barrels is a cross duct 28 and connected as a branch line to the cross duct is a tubing 30 provided with a shut-off and regulator valve 32. When the valve is closed and drive mechanism within barrel 16 is released, diluent is forced through the duct 28 into the cartridge 26 and mixes with the contents of the second cartridge or dissolves its contents. Now, when the regulator valve 32 is opened, and the drive mechanism in the second barrel 22 is released, the medication will be forced out through the tubing 30 and the hypodermic needle 34 at the end of the tubing.

Referring more in particular to FIG. 4, it will be noted that the first barrel 16 is comprised of an outer cylinder 36, preferably of transparent glass or plastic, shouldered intermediate its ends as indicated at 38 and the inner cartridge 18 is seated against the shoulder and comprises a transparent wall 40, the cartridge containing the diluent 20 being normally retained in the cartridge by a piston 42 at one end of the cartridge and a stopper 44 at the other end thereof. The stopper is provided with a thin diaphragm 46 which, when the piston 42 is operated, exerts a pressure on the diluent and which in turn causes the diluent to transmit a pressure to the diaphragm, thereby distending and finally bursting it. Piercing pins, as pins 48 in FIG. 5., forming part of the cartridge end stopper 44 may be provided to ensure bursting of the diaphragm when the same is distended and impinges on the pins. Further amplification of this feature will be found in the continuation application of Sarnoff 700 299, filed J an. 24, 1968. The cartridge is held within the outer cylinder by an end cap 52 having a split skirt 54, as at 55, FIG. 5, the inner portion of the skirt having a recess 56 circumferentially of the inner wall to spring over arcuate beads 58 on the wall of the cylinder 36. To retain the split skirt in place and preventing the spread of the skirt portion of the cap, there is provided an internally tapered sleeve 60, frictionally slipped over the skirt portion of the cap. The duct 2-8 passes in liquid tight relationship through the cap and has its inner end flanged as at 62 to prevent outward dislodgement of the duct from the stopper.

To effect the distension of the diaphragm, its bursting and to drive the liquid out of the cartridge, there is provided a plunger 64 on the end of a plunger rod 66, the rear end of the rod passing through an aperture 68 larger in diameter than the diameter of the rod and located in a second end stopper 70, of hard material. The end stopper acts as a firing seat and is fixed in place in the barrel 16 in any desired manner as by the provision. of pins or screws 69 passing through the barrel wall and engaging in the material of the stopper. The stopper 70 in the cocked position of parts is engaged by a notch 74- in the rod and thus prevents the rod and plunger 64 from moving under the influence exerted thereto by a heavy spring 76 reacting between the plunger and the inner face of stopper 70. A safety device is provided in the form of an angled safety pin 78 which when engaged in the aperture 68 of the stopper holds the notch in the rod in engagement with the stopped and prevents inadvertent lateral freeing movement of the rod. With the safety pin 78 Withdrawn from the aperture, the rod may be moved laterally, effecting release of notch 74 from the stopper. The spring 76 is now effective to drive the fluid out of cartridge 18.

The second barrel 22 and associated parts are fairly similar to the barrel 16 and its parts. A distinction between the two may be in the strength of the spring 76 compared with spring 80 in barrel 22. The spring 76 can be of such strength as to exert a greater force when it is fully expanded within the barrel 16 and cartridge 18 than when the spring 80 is fully compressed in barrel 22 and the cartridge 82 within the barrel.

This is so since it may be desirable to prevent retrovert action of the fluid when the spring 80 is released and to expel all of the contents of the cartridge 82 into the duct 28 rather than into cartridge 18 in barrel 16. However, this is not absolutely necessary since, even if fluid be driven back into cartridge 16, it will be eventually expelled by the action of spring 76. Preferably, the springs are alike. The design of the mechanism for sealing off the contents of the cartridge 82 from the duct 28 may also be different. Since initially a fluid is forced into the cartridge 82, the opening in the duct to said cartridge may be sealed off by a thin membrane 84. Behind the membrane and within the cartridge is placed the medication here shown as a powder tablet 86, but the medication may be a fluid. Against the medication is a frictionally held stopper or piston 88. When the safety pin 78 of barrel 16 is withdrawn, plunger rod 66 in barrel 16 can be released to the action of spring 76 by thrusting the plunger rod to one side to disengage notch 74 from the stopper and the liquid in the cartridge 18 will be caused to flow with considerable velocity into the cartridge 82, causing a thorough admixing of the medicament with the fluid or a dissolving of the medicament in the fluid. The frictionally held stopper is then driven back. Because of this arrangement, no air is admixed with the liquid introduced into cartridge 82. When the safety pin of the second barrel 22 is removed and the rod thrust aside to free the notch in the rod from the end stopper in that barrel, the contents of cartridge 82 will be expelled via the duct 28 into the tubing 30.

During the transfer of the fluid from cartridge 18 to cartridge 82, the regulator valve 32 is closed. During transfer of fluid from cartridge 82 and possibly from cartridge 18 to tubing 30, the regulator valve is opened to the extent desired for appropriate administration of the medicament to a patient.

fln the line of tubing between the regulator valve and the needle there may be placed a sight or drop meter 90 to visibly show the rate of flow of the medicament through the tubing.

Also in the line leading to the drop meter as between the flow regulator and the drop meter there is interposed a flow rate restriction element. For the purposes of illustrating this invention, the element is shown in a most simple form. 'It comprises a nipple 92 with intermediate external flange 94 to enable hose sections to be attached to the nipple, the orifice 96 through the nipple being of a size predetermined in accordance with the medicament to be administered and the maximum rate of flow which could be tolerated by the patient. It is obvious that other permanent forms of orifice restrictive devices may be used as by molding a restriction in the tubing.

After the barrels have been loaded or reloaded with the cartridges, by preliminarily cocking the springs, and by removing the end caps on the barrels and replacing them, the two barrels may be laid within the casing 10 provided therefor. The casing is preferably made of transparent plastic material slotted in an end Wall as indicated at 98 for accommodating the branch passage of the duct. The opposite end wall of the casing is provided with vertical slots 100 to accommodate the cocked plunger rods and the safety pins 78. 'Overlying the casing and in frictional engagement therewith is the skirted cover 12 of material similar to that of the casing.

In the use of the assembly, the loaded casing may be placed at any convenient location close to a patient and one need not suspend the equipment as in gravity fed dispensers. Thereafter flow of medicament to the patient having been initiated and regulated, the device may be left unattended since the flow to and through the needle will take place so long as a spring in a barrel is expanding, and because of the nipple, never at an excessive rate.

In the modification of the invention shown in FIG. 6, a single barrel syringe 102 is disclosed. This syringe may be of the same construction as the righthand one of the pair shown in FIG. 4, and the diluent is replaced by the medicament, which may be in solution or be an admixture of medicament and diluent, as is conventional in the art. To this syringe there is directly attached the tubing 50, regulator 32, nipple 92, drop meter and needle 34 in the same arrangement as may be employed in conjunction with the multibarrel infusion device.

What is claimed is:

1. In an automatic infusion device, a hollow infusion needle, a pair of containers, a conduit interconnecting the containers, a substance in one container and a diluent in the other, drive means under stored potential energy in one of the containers for transfer of the contents of of one of the containers via the conduit to the contents of the other for commingling said contents, other conduit means in fluid communication with the conduit and the infusion needle, and drive means under stored potential energy in said other of the containers to expel the corn mingled contents from said other container through the other conduit means and infusion needle.

2. The structure of claim 1 in which the means for transfering the contents and the means for expelling the commingled contents are springs under compression acting on pistons.

3. The structure of claim 2 wherein the spring in the diluent container is stronger when expanded in that container than the spring in the other container where it is fully compressed. v

4. The structure of claim 1 wherein a valve is provided for said other conduit means.

5. The structure of claim 4 wherein a nipple with orifice of predetermined side is interposedin the other conduit means.

6. The structure of claim 4 wheerin a drop meter is interposed between the valve and the needle. 7

7. The structure of claim 6 wherein a nipple with orifice of predetermined side is interposed in the other conduit means between the containers and the drop meter.

8. The structure of claim 1 wherein the container having a diluent is provided with a burstable diaphragm, said diaphragm being in the path of movement of the diluent from its container to the substance in the other container.

9. The structure of claim 1 wherein the substance in the other container is confined between a ruptura'ble dia: phragm adjacent the commingled content expelling end of said container and a frictionally held stopper moveable in said other container as the diluent is driven into said other container.

10. The structure of claim 1 wherein the injection needle is provided at the end of the other conduit means.

11. The structure of claim 1 wherein a container comprises a barrel with a circumferential shoulderinteriorly thereof intermediate its ends, a cartridge being seated within the barrel against the shoulder, said cartridge hav' ing a rupturable end stopper, and a piston is provided with material between the stopper and piston, a spring impeled plunger being operative on the piston to drive the cartridge contents therefrom through the bursta'ble diaphragm and there is further provided a removable end cap at an end of the barrel for holding the cartridge in place, said spring impeled plunger forming one of the drive means.

References Cited UNITED STATES PATENTS J 6 1/1955 Raiche 128-216 7,1951 Hall 123F272 XR 1/1959 Ratclitf m1 ..128-234XR 8/1962 Gran 128-214 10/1964 Beall et a1. 123-214 FOREIGN PATENTS 8/1957 Sweden. 10/1925 Germany.

RICHARD A. GAUDET, Primary Examiner. MART'IN F. MAJESTIC, Assistant Examiner.

U.S. Cl. X.R.

US3451393A 1966-02-07 1966-02-07 Automatic infusion device Expired - Lifetime US3451393A (en)

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Cited By (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3595232A (en) * 1968-08-19 1971-07-27 Saul Leibinsohn Nongravitational infusion assembly
US3888239A (en) * 1974-06-21 1975-06-10 Morton K Rubinstein Fluid injection system
US3895631A (en) * 1974-02-04 1975-07-22 Alza Corp Liquid infusion unit
US4065230A (en) * 1975-01-17 1977-12-27 Hart Associates, Inc. Reciprocating infusion pump and directional adapter set for use therewith
EP0014006A2 (en) * 1979-01-25 1980-08-06 Survival Technology, Inc. Automatic, plural spring actuated, injecting device
US4267836A (en) * 1976-11-12 1981-05-19 Whitney Douglass G Injection device and method
US4381006A (en) * 1980-11-10 1983-04-26 Abbott Laboratories Continuous low flow rate fluid dispenser
US4382753A (en) * 1979-03-09 1983-05-10 Avi, Inc. Nonpulsating IV pump and disposable pump chamber
US4391600A (en) * 1979-03-09 1983-07-05 Avi, Inc. Nonpulsating IV pump and disposable pump chamber
US4410322A (en) * 1979-03-09 1983-10-18 Avi, Inc. Nonpulsating TV pump and disposable pump chamber
WO1986006967A1 (en) * 1985-05-20 1986-12-04 Survival Technology, Inc. Automatic medicament ingredient mixing and injecting apparatus
US4666430A (en) * 1984-12-05 1987-05-19 I-Flow Corporation Infusion pump
US4857048A (en) * 1987-05-29 1989-08-15 Hewlett-Packard Company IV pump and disposable flow chamber with flow control
US4997420A (en) * 1989-12-28 1991-03-05 Lefevre Robert J Portable drug delivery device including pump with tapered barrel
US5100389A (en) * 1988-06-21 1992-03-31 Vaillancourt Vincent L Ambulatory infusion pump
US5318539A (en) * 1986-10-17 1994-06-07 Alexander G. B. O'Neil Liquid feeding apparatus utilizing capillary tubing, and syringe driver
US5320503A (en) * 1988-05-17 1994-06-14 Patient Solutions Inc. Infusion device with disposable elements
US5584667A (en) * 1988-05-17 1996-12-17 Davis; David L. Method of providing uniform flow from an infusion device
EP0836505A1 (en) * 1995-06-06 1998-04-22 Science Incorporated Medicament dispenser
US5803712A (en) * 1988-05-17 1998-09-08 Patient Solutions, Inc. Method of measuring an occlusion in an infusion device with disposable elements
US5911716A (en) * 1992-01-24 1999-06-15 I-Flow Corporation Platen pump
US6234795B1 (en) * 2000-01-21 2001-05-22 Ultradent Products, Inc. Flexible mixer extender
US6241125B1 (en) * 1996-10-24 2001-06-05 Kenneth H. Jacobsen System and kit accessories for dispensing reactive two component materials
US6251098B1 (en) 1992-01-24 2001-06-26 I-Flow, Corp. Fluid container for use with platen pump
US6358239B1 (en) 1992-01-24 2002-03-19 I-Flow Corporation Platen pump
EP1475114A2 (en) * 1994-09-02 2004-11-10 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Injection system suitable for the administration of semisolid, sustained-release pharmaceutical compositions of gelable peptide salts
US20070105433A1 (en) * 2005-11-07 2007-05-10 Japan Aviation Electronics Industry, Limited Electric connector having an excellent grounding function
US20080215029A1 (en) * 1993-01-22 2008-09-04 I-Flow Corporation Platen pump
WO2018096149A1 (en) * 2016-11-28 2018-05-31 Idorsia Pharmaceuticals Ltd Device for dispensing a substance

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2721752C2 (en) * 1977-05-13 1983-12-29 Siemens Ag, 1000 Berlin Und 8000 Muenchen, De
GB9611562D0 (en) * 1996-06-03 1996-08-07 Applied Research Systems Device
EP2034945A1 (en) 2006-06-21 2009-03-18 Novo Nordisk A/S A one-hand operated drug mixing and expelling device
DE102007060131A1 (en) * 2007-12-13 2009-06-25 Technische Universität Dresden Explanted organ's vessel connection filling method for medical field, involves continuously emptying dosage device and simultaneously withdrawing hose from vessel connection as long as vessel connection is completely filled

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DE419869C (en) * 1924-10-23 1925-10-12 Robert Roehr Dr Swine erysipelas-vaccination equipment
US2129983A (en) * 1936-04-06 1938-09-13 Bacon Jay Harvey Surgical appliance
US2362025A (en) * 1943-01-26 1944-11-07 Price Alison Howe Apparatus for administering blood plasma
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Publication number Priority date Publication date Assignee Title
DE419869C (en) * 1924-10-23 1925-10-12 Robert Roehr Dr Swine erysipelas-vaccination equipment
US2129983A (en) * 1936-04-06 1938-09-13 Bacon Jay Harvey Surgical appliance
US2362025A (en) * 1943-01-26 1944-11-07 Price Alison Howe Apparatus for administering blood plasma
US2496559A (en) * 1945-09-17 1950-02-07 Piechaczek Alojzy Surgical and medical syringes
US2693801A (en) * 1951-01-08 1954-11-09 Forcman Joseph Safety cutoff valve for liquid administering apparatus
US2699167A (en) * 1952-04-25 1955-01-11 Paul A Raiche Hypodermic injector
US2798488A (en) * 1954-09-15 1957-07-09 Merck & Co Inc Syringe unit
US2869543A (en) * 1957-08-23 1959-01-20 Iowa Cooperative Ass Injector
US3048171A (en) * 1958-11-03 1962-08-07 Bio Physical Res Inc Intravenous injection device
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Cited By (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3595232A (en) * 1968-08-19 1971-07-27 Saul Leibinsohn Nongravitational infusion assembly
US3895631A (en) * 1974-02-04 1975-07-22 Alza Corp Liquid infusion unit
US3888239A (en) * 1974-06-21 1975-06-10 Morton K Rubinstein Fluid injection system
US4065230A (en) * 1975-01-17 1977-12-27 Hart Associates, Inc. Reciprocating infusion pump and directional adapter set for use therewith
US4267836A (en) * 1976-11-12 1981-05-19 Whitney Douglass G Injection device and method
EP0014006A2 (en) * 1979-01-25 1980-08-06 Survival Technology, Inc. Automatic, plural spring actuated, injecting device
EP0014006A3 (en) * 1979-01-25 1980-09-17 Survival Technology, Inc. Automatic, plural spring actuated, injecting device
US4391600A (en) * 1979-03-09 1983-07-05 Avi, Inc. Nonpulsating IV pump and disposable pump chamber
US4410322A (en) * 1979-03-09 1983-10-18 Avi, Inc. Nonpulsating TV pump and disposable pump chamber
US4382753A (en) * 1979-03-09 1983-05-10 Avi, Inc. Nonpulsating IV pump and disposable pump chamber
US4381006A (en) * 1980-11-10 1983-04-26 Abbott Laboratories Continuous low flow rate fluid dispenser
US4666430A (en) * 1984-12-05 1987-05-19 I-Flow Corporation Infusion pump
WO1986006967A1 (en) * 1985-05-20 1986-12-04 Survival Technology, Inc. Automatic medicament ingredient mixing and injecting apparatus
US4689042A (en) * 1985-05-20 1987-08-25 Survival Technology, Inc. Automatic medicament ingredient mixing and injecting apparatus
US5318539A (en) * 1986-10-17 1994-06-07 Alexander G. B. O'Neil Liquid feeding apparatus utilizing capillary tubing, and syringe driver
US4857048A (en) * 1987-05-29 1989-08-15 Hewlett-Packard Company IV pump and disposable flow chamber with flow control
US6146109A (en) * 1988-05-17 2000-11-14 Alaris Medical Systems, Inc. Infusion device with disposable elements
US5803712A (en) * 1988-05-17 1998-09-08 Patient Solutions, Inc. Method of measuring an occlusion in an infusion device with disposable elements
US5320503A (en) * 1988-05-17 1994-06-14 Patient Solutions Inc. Infusion device with disposable elements
US5584667A (en) * 1988-05-17 1996-12-17 Davis; David L. Method of providing uniform flow from an infusion device
US6312227B1 (en) 1988-05-17 2001-11-06 I-Flow Corp. Infusion device with disposable elements
US5100389A (en) * 1988-06-21 1992-03-31 Vaillancourt Vincent L Ambulatory infusion pump
US4997420A (en) * 1989-12-28 1991-03-05 Lefevre Robert J Portable drug delivery device including pump with tapered barrel
US6871759B2 (en) 1992-01-24 2005-03-29 I-Flow Corporation Platen pump
US7337922B2 (en) 1992-01-24 2008-03-04 I-Flow Corporation Platen pump
US7083068B2 (en) 1992-01-24 2006-08-01 I-Flow Corporation Platen pump
US20050211725A1 (en) * 1992-01-24 2005-09-29 Rake Kenneth W Platen pump
US6251098B1 (en) 1992-01-24 2001-06-26 I-Flow, Corp. Fluid container for use with platen pump
US5911716A (en) * 1992-01-24 1999-06-15 I-Flow Corporation Platen pump
US6358239B1 (en) 1992-01-24 2002-03-19 I-Flow Corporation Platen pump
US20040108333A1 (en) * 1992-01-24 2004-06-10 Rake Kenneth W. Platen pump
US20080215029A1 (en) * 1993-01-22 2008-09-04 I-Flow Corporation Platen pump
EP1475114A2 (en) * 1994-09-02 2004-11-10 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Injection system suitable for the administration of semisolid, sustained-release pharmaceutical compositions of gelable peptide salts
EP1475114A3 (en) * 1994-09-02 2004-11-24 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Injection system suitable for the administration of semisolid, sustained-release pharmaceutical compositions of gelable peptide salts
EP0836505A1 (en) * 1995-06-06 1998-04-22 Science Incorporated Medicament dispenser
EP0836505A4 (en) * 1995-06-06 2000-01-12 Science Inc Medicament dispenser
US6241125B1 (en) * 1996-10-24 2001-06-05 Kenneth H. Jacobsen System and kit accessories for dispensing reactive two component materials
US6234795B1 (en) * 2000-01-21 2001-05-22 Ultradent Products, Inc. Flexible mixer extender
US7458829B2 (en) 2005-11-07 2008-12-02 Japan Aviation Electronics Industry, Limited Electric connector having an excellent grounding function
US20070105433A1 (en) * 2005-11-07 2007-05-10 Japan Aviation Electronics Industry, Limited Electric connector having an excellent grounding function
WO2018096149A1 (en) * 2016-11-28 2018-05-31 Idorsia Pharmaceuticals Ltd Device for dispensing a substance

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NL6701783A (en) 1967-08-08 application
FR1510549A (en) 1968-01-19 grant
GB1114238A (en) 1968-05-22 application
DE1566649A1 (en) 1970-04-30 application
BE693765A (en) 1967-07-17 grant

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