US4146653A - Process of manufacturing dragees - Google Patents

Process of manufacturing dragees Download PDF

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Publication number
US4146653A
US4146653A US05/823,471 US82347177A US4146653A US 4146653 A US4146653 A US 4146653A US 82347177 A US82347177 A US 82347177A US 4146653 A US4146653 A US 4146653A
Authority
US
United States
Prior art keywords
xylitol
sorbitol
coating
dragee
dragees
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US05/823,471
Other languages
English (en)
Inventor
Helmut Mader
Johann Hopfgartner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arcana Chem-Pharm Fabrik GmbH
J Pfrimmer und Co GmbH and Co KG
Original Assignee
Arcana Chem-Pharm Fabrik GmbH
J Pfrimmer und Co GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arcana Chem-Pharm Fabrik GmbH, J Pfrimmer und Co GmbH and Co KG filed Critical Arcana Chem-Pharm Fabrik GmbH
Application granted granted Critical
Publication of US4146653A publication Critical patent/US4146653A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/343—Products for covering, coating, finishing, decorating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats
    • A61K9/2826—Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G2200/00—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF containing organic compounds, e.g. synthetic flavouring agents
    • A23G2200/06—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF containing organic compounds, e.g. synthetic flavouring agents containing beet sugar or cane sugar if specifically mentioned or containing other carbohydrates, e.g. starches, gums, alcohol sugar, polysaccharides, dextrin or containing high or low amount of carbohydrate

Definitions

  • the present invention relates to pharmaceutical preparations, and, more particularly, to a method of making dragees.
  • Dragees represent oral application forms of medicaments, i.e. cores obtained in any manner containing in suitable quantities the medicaments or pharmaceuticals, and provided with a coating, i.e. the dragee casing.
  • a coating i.e. the dragee casing.
  • Such coating can be used for various purposes.
  • the surface of the dragee should thus be made smooth, so that it can be readily swallowed in which connection any unpleasant taste inherent in the medicament should possibly be masked.
  • the coating should improve the appearance of the dragee, distinguish it by means of color and, in many cases, exert an effect on the breaking up of the dragee core in the gastrointestinal tract, in particular retard the dissolving of the effective substances.
  • Such dragee coatings are often made especially of sugar composition which may contain dye and pigment additives, as well as film-forming agents.
  • the coatings are applied from solutions in aqueous or organic solvents often in several layers by spraying such solutions, possibly in connection with the simultaneous addition of further pulverulent coating materials, on the tablets or dragee cores arranged in a rotating dragee-container or a fluidized-bed device, while blowing in warm air.
  • film-forming agents there may be employed generally shellac, cellulose derivatives, such as cellulose acetate phthalate, as well as possibly substituted polymers of acrylic or methacrylic acid, in which connection such film-forming agents should provide some resistance to gastric juice and retard the release of the active substances.
  • the coating must provide an optimal seal in the case of unpleasantly tasting and strongly smelling active agents.
  • the film-forming materials based on high-molecular substances which could as such provide a good seal, lead to a delay in the breaking up of the dragee, which is frequently undesirable.
  • the use of such film-forming agents for the coating also represents an undesirable burdening of the patient, in particular in the case of such unpleasantly tasting or smelling medicaments, that must be taken in considerable amounts by patients and are thus applied generally in the form of microdragees, that can be swallowed more readily in large numbers and possess a diameter of 0.4-4mm, preferably at most 1.5-2mm.
  • Such burdening of the patient takes place especially because the percentage of the film-forming polymers is relatively large in comparison with the active agent in the case of microdragees.
  • microdragees are particularly suitable for administering large amounts of badly tasting or smelling medicaments, such as essential amino acids or their keto and hydroxy analogs that must be dosed, e.g. in the amounts of about 15 to 20g per day in the case of uremia patients, no satisfactory industrial method of manufacture was possible until the present time.
  • the solution of the problem failed especially on the fact that the processes and coating means known until the present for masking the taste and smell either exhibit unsatisfactory effects during the dragee-making or there are required excessive amounts of such coating materials, that are not desired as such, but must then be administered to the patient together with the active materials.
  • Reactions may also take place between the coatings and the medicaments, that are frequently reactive and unpleasantly tasting and smelling, which reactions may occur during the manufacture of the dragees through the action of high temperature of drying or which result from the use of organic or aqueous solutions; such reactions may also introduce moisture and decomposition, which later comprise microbial decay.
  • Coatings consisting of fat can be penetrated by lipophilic substances and can thus be used only to a limited extent.
  • a fusion product or melt
  • xylitol and sorbitol for the application of the coating.
  • a fused mixture of xylitol and sorbitol in the quantitative ratio of 9:1 to 1:1.
  • the sugar alcohols xylitol and sorbitol are distinguished by their great chemical stability and indifference, i.e., inertness, so that the two can be used for encasing a great variety of badly tasting and smelling cores of medicaments.
  • the mixture possesses a melting point, which is clearly situated below 100° C.
  • the sugar-alcohol fusion or melt rapidly solidifies into a dense glass-like mass, which is distinguished through a pleasantly sweet and fresh taste of its own.
  • the novel coating is capable of binding and compensating the bad smelling and tasting substance even in large amounts.
  • the invention relates to a process of manufacturing dragees for peroral administration of medicaments by coating the medicament-containing dragee cores with a dense coating, characterized in that the dragee cores are coated with a melt of xylitol and sorbitol at 85°-90° C.
  • the great water-binding capacity of the coating consisting of the two sugar alcohols has turned out as a further advantage, so that the dragee cores thus coated possess an almost unchanged content of water through a long period of time even at high air moisture.
  • the reduced permeability to oxygen is also of advantage in relation to the dragee coatings produced by standard methods. This is all the more unexpected, since the two sugar alcohols can be used only unsatisfactorily as dragee-making agents in the known dragee-making processes.
  • xylitol or sorbitol is sprayed on the cores, e.g., in the form of a 50 or 60% aqueous solution, as previously customary for sugar solutions, one obtains brittle, cracked and irregular formations having a low durability.
  • the process of the invention represents an elegant economical method of manufacturing dragees, in particular microdragees, since sorbitol and/or xylitol, preferably as a mixture in the indicated quantitative ratio, especially in a ratio of 72% by weight xylitol and 28% by weight sorbitol, are mixed and heated and the melt is applied to the cores as a coating.
  • the melting temperature is only about 85° C.
  • the application of the melt at a temperature of about 85° C. on the microdragee cores of pellets, pre-manufactured in known manner and containing the active ingredients, can be effected by means of devices ordinarily used for such purposes at the present time, e.g., in a dragee container, preferably by means of an immersion or spray tube, which is surrounded by a flow of rotating cores or pellets.
  • a dragee container preferably by means of an immersion or spray tube, which is surrounded by a flow of rotating cores or pellets.
  • the viscosity is sufficiently low for securing a rapid distribution of the fused mixture of substances on the core surface during the spraying.
  • the cooling on the core then produces a rapid increase in viscosity and solidification of the coating material, so that a uniform microcrystalline layer in the form of the solidified polyol mixture is formed. This brings about the great uniformity of the coating as well as the excellent density and durability of the dragee casing.
  • microdragees produced in accordance with the invention with the sugar alcohols sorbitol and xylitol and having a diameter of up to 4mm are characterized during rise thereof, in that their osmotic effect is unfolded immediately, due to their capacity of immediately beginning to dissolve, so that a sufficient amount of saliva is soon formed in the mouth, which makes it possible to swallow the form of administration without an additional liquid.
  • Medicaments such as keto or hydroxy analogs of amino acids, that possess a particularly unpleasant taste, can now be coated without problems in the form of granulates or pellets.
  • these fat-soluble active compounds do not diffuse through the dragee casings of the invention even when stored for long periods of time.
  • amino or keto compounds for example, do not react with the sugar alcohols, which is in contrast with the conventional sugar or starch-containing coating materials.
  • the encasement with the sugar alcohols xylitol and sorbitol makes the taking of dragees possible also for diabetics, since such carbohydrates can be utilized in the organism independently of insulin.
  • the caries-promoting effect of the carbohydrates heretofore used represents an additional disadvantage of considerable importance.
  • the coating of xylitol and sorbitol in accordance with the present invention prevents or at least reduces the risk of caries disease from this point of view.
  • the medicaments to be made into dragees can either be in the form of flat or convex tablet blanks, round pills or in the form of small compressed elements, e.g., pellets, spray granulates or the like, and then provided with the dragee coating of the present invention.
  • 1700g ⁇ -keto acids is applied by means of the customary adhesive solutions, e.g., PVP or gum arabic on a 0.4-0.5mm core through spraying.
  • the air-dried pellets are then coated in a dragee container or kettle by means of a spray tube with a melt consisting of 1728g xylitol and 672g sorbitol.
  • 900g of essential amino acids are processed into pellets as in example 1 and then coated with a melt consisting of 720g xylitol and 480g sorbitol.
  • 1400g ⁇ -keto acids and 250g essential amino acids are processed into pellets as in example 1 and then coated with a melt consisting of 1040g xylitol, 260g sorbitol, 60g water and 0.15g polyglycol.
  • 1700g spherical microcompressed elements of amino acids, inorganic components and vitamins is coated with a melt of 1440g xylitol, 560g sorbitol and 100g water.
  • 580g ⁇ -hydroxy acid is processed into pellets as in example 1, which pellets are then coated with 420g of a xylitol melt.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Confectionery (AREA)
US05/823,471 1976-08-11 1977-08-10 Process of manufacturing dragees Expired - Lifetime US4146653A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2636152A DE2636152C2 (de) 1976-08-11 1976-08-11 Verfahren zur Herstellung von Dragees
DE2636152 1976-08-11

Publications (1)

Publication Number Publication Date
US4146653A true US4146653A (en) 1979-03-27

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ID=5985232

Family Applications (1)

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US05/823,471 Expired - Lifetime US4146653A (en) 1976-08-11 1977-08-10 Process of manufacturing dragees

Country Status (15)

Country Link
US (1) US4146653A (de)
JP (1) JPS5320416A (de)
AT (1) AT352884B (de)
AU (1) AU510921B2 (de)
BE (1) BE857659A (de)
CA (1) CA1086650A (de)
CH (1) CH630259A5 (de)
DE (1) DE2636152C2 (de)
ES (1) ES461516A1 (de)
FR (1) FR2361105A1 (de)
GB (1) GB1547527A (de)
HU (1) HU176597B (de)
IT (1) IT1086479B (de)
NL (1) NL7708808A (de)
SE (1) SE431935B (de)

Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4388328A (en) * 1981-10-15 1983-06-14 Warner-Lambert Company Sorbitol containing mixture encapsulated flavor
US4626427A (en) * 1984-10-15 1986-12-02 Richardson-Vicks Inc. Cardamom seed preparation being effective against bad breath
US4753790A (en) * 1986-12-16 1988-06-28 Warner-Lambert Company Sorbitol coated comestible and method of preparation
EP0306465A1 (de) * 1987-08-31 1989-03-08 Nicasystem Aktiebolag Granuliertes Produkt
US4828845A (en) * 1986-12-16 1989-05-09 Warner-Lambert Company Xylitol coated comestible and method of preparation
US4931294A (en) * 1988-03-21 1990-06-05 Wm. Wrigley Jr. Company Environmentally stable chewing gum composition containing xylitol
US4976972A (en) * 1988-02-24 1990-12-11 Wm. Wrigley Jr. Company Chewing gum with improved sweetness employing xylitol rolling compound
US5270061A (en) * 1992-03-26 1993-12-14 Wm. Wrigley Jr. Company Dual composition hard coated gum with improved shelf life
US5286502A (en) * 1992-04-21 1994-02-15 Wm. Wrigley Jr. Company Use of edible film to prolong chewing gum shelf life
US5290569A (en) * 1990-04-12 1994-03-01 Shionogi & Co., Ltd. Coated composition and its preparation process
US5536511A (en) * 1994-05-06 1996-07-16 Wm. Wrigley Jr. Company Chewing gum pellet coated with a hard coating containing erythritol and xylitol
US5603970A (en) * 1994-05-06 1997-02-18 Wm. Wrigley Jr. Company Chewing gum pellet coated with a hard coating containing erythritol
US5665406A (en) * 1992-03-23 1997-09-09 Wm. Wrigley Jr. Company Polyol coated chewing gum having improved shelf life and method of making
US6455080B1 (en) 1997-12-29 2002-09-24 Wm. Wrigley Jr., Company Chewing gum containing controlled release acyclic carboxamide and method of making
US6506424B2 (en) 2000-05-22 2003-01-14 Dandy Sakiz Ve Sekerleme Sanayi A.S. Multicolored chewing gum with crunchy transparent coating
US6627233B1 (en) 1997-09-18 2003-09-30 Wm. Wrigley Jr. Company Chewing gum containing physiological cooling agents
WO2004008877A1 (en) * 2002-07-23 2004-01-29 Mars Incorporated Polyol coated food products
WO2004008878A1 (en) * 2002-07-23 2004-01-29 Mars, Incorporated Barrier layer based on polyol
US20040033288A1 (en) * 2002-08-14 2004-02-19 Song Joo Hae Methods for manufacturing coated confectionary products
US20040253357A1 (en) * 2003-05-26 2004-12-16 De Zarate Dominique Ortiz Hard dragee-coating process
WO2005063203A2 (en) * 2003-12-31 2005-07-14 Vectura Ltd Multiparticulate formulations for oral delivery
US20050163886A1 (en) * 2002-08-14 2005-07-28 Song Joo H. Methods for manufacturing coated confectionary products
US20050249858A1 (en) * 2004-05-07 2005-11-10 Jong Kyun Lee Xylitol coated functional dietary fiber supplement
US20060198924A1 (en) * 2002-08-14 2006-09-07 Joo Song Methods for manufacturing coated confectionery products
US20070048418A1 (en) * 2002-07-23 2007-03-01 Mars, Incorporated Polyol coated food product
EP1774858A1 (de) * 2005-10-13 2007-04-18 Valpharma International S.P.A. Nährzusammensetzungen auf der Basis von Aminosäuren
US20070248717A1 (en) * 2004-02-26 2007-10-25 Johnson Sonya S Confections Containing a Blend of Physiological Cooling Agents
WO2008114013A1 (en) * 2007-03-19 2008-09-25 The Technology Partnership Plc Coating of confectionery and tablets

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2912411B2 (de) * 1979-03-29 1981-02-05 August Storck Kg, 4802 Halle Zähplastische, zuckerfreie Süßwarenmasse auf der Grundlage von Sorbit und eines Quellstoffs und Verfahren zu ihrer Herstellung
IT1121023B (it) * 1979-09-12 1986-03-26 Ferrero & C Spa P Prodotto confettato e procedimento per la sua fabbricazione
GB2079129B (en) * 1979-09-24 1984-08-30 Life Savers Inc Sugarless coating for comestibles and method
WO1981001100A1 (fr) * 1979-10-17 1981-04-30 Roquette Freres Procede de drageification dure au sorbitol et produits ainsi obtenus
FR2467597A1 (fr) * 1979-10-17 1981-04-30 Roquette Freres Procede de drageification dure au sorbitol et produits ainsi obtenus
JPS6011804U (ja) * 1983-07-05 1985-01-26 株式会社クボタ 運搬車
JPS6328329A (ja) * 1986-07-21 1988-02-06 尾前工業株式会社 果実類の保護袋
JPS6318052U (de) * 1986-07-21 1988-02-05
JPS63119346U (de) * 1987-01-27 1988-08-02
EP0339958B1 (de) * 1988-04-27 1993-09-15 Dow Corning Corporation Eingekapselte Silicon-Antischaummittel
GB2253164B (en) * 1991-02-22 1994-10-05 Hoechst Uk Ltd Improvements in or relating to electrostatic coating of substrates of medicinal products

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US3185626A (en) * 1963-03-06 1965-05-25 Sterling Drug Inc Tablet coating method
US3383237A (en) * 1964-01-29 1968-05-14 Richardson Merrell Inc Tablet coating
US3556814A (en) * 1967-09-18 1971-01-19 Gen Foods Corp Process of coating food
US3779783A (en) * 1970-06-20 1973-12-18 Dynamit Nobel Ag Meltable coating compositions, particularly for foodstuffs and pharmaceutical preparations
US3882228A (en) * 1969-11-28 1975-05-06 Aspro Nicholas Ltd Analgesic formulations
US3914434A (en) * 1969-08-22 1975-10-21 Hoffmann La Roche Non-cariogenic foods and delicacies containing xylitol as a sugar substitute
US3991225A (en) * 1974-02-01 1976-11-09 Tennessee Valley Authority Method for applying coatings to solid particles

Patent Citations (7)

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US3185626A (en) * 1963-03-06 1965-05-25 Sterling Drug Inc Tablet coating method
US3383237A (en) * 1964-01-29 1968-05-14 Richardson Merrell Inc Tablet coating
US3556814A (en) * 1967-09-18 1971-01-19 Gen Foods Corp Process of coating food
US3914434A (en) * 1969-08-22 1975-10-21 Hoffmann La Roche Non-cariogenic foods and delicacies containing xylitol as a sugar substitute
US3882228A (en) * 1969-11-28 1975-05-06 Aspro Nicholas Ltd Analgesic formulations
US3779783A (en) * 1970-06-20 1973-12-18 Dynamit Nobel Ag Meltable coating compositions, particularly for foodstuffs and pharmaceutical preparations
US3991225A (en) * 1974-02-01 1976-11-09 Tennessee Valley Authority Method for applying coatings to solid particles

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Cited By (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4388328A (en) * 1981-10-15 1983-06-14 Warner-Lambert Company Sorbitol containing mixture encapsulated flavor
US4626427A (en) * 1984-10-15 1986-12-02 Richardson-Vicks Inc. Cardamom seed preparation being effective against bad breath
AU579404B2 (en) * 1984-10-15 1988-11-24 Richardson G.M.B.H. Preparation being effective against bad breath
US4753790A (en) * 1986-12-16 1988-06-28 Warner-Lambert Company Sorbitol coated comestible and method of preparation
US4828845A (en) * 1986-12-16 1989-05-09 Warner-Lambert Company Xylitol coated comestible and method of preparation
EP0306465A1 (de) * 1987-08-31 1989-03-08 Nicasystem Aktiebolag Granuliertes Produkt
US4976972A (en) * 1988-02-24 1990-12-11 Wm. Wrigley Jr. Company Chewing gum with improved sweetness employing xylitol rolling compound
US4931294A (en) * 1988-03-21 1990-06-05 Wm. Wrigley Jr. Company Environmentally stable chewing gum composition containing xylitol
US5290569A (en) * 1990-04-12 1994-03-01 Shionogi & Co., Ltd. Coated composition and its preparation process
US5665406A (en) * 1992-03-23 1997-09-09 Wm. Wrigley Jr. Company Polyol coated chewing gum having improved shelf life and method of making
US5376389A (en) * 1992-03-26 1994-12-27 Wm. Wrigley Jr. Company Hard coated chewing gum with improved shelf life, with xylitol and polyol coatings
US5270061A (en) * 1992-03-26 1993-12-14 Wm. Wrigley Jr. Company Dual composition hard coated gum with improved shelf life
US5433960A (en) * 1992-04-21 1995-07-18 Wm. Wrigley Jr. Company Chewing gum including agent containing edible film
US5409715A (en) * 1992-04-21 1995-04-25 Wm. Wrigley Jr. Company Use of edible film to prolong chewing gum shelf life
US5286502A (en) * 1992-04-21 1994-02-15 Wm. Wrigley Jr. Company Use of edible film to prolong chewing gum shelf life
US5376388A (en) * 1992-04-21 1994-12-27 The Wm. Wrigley Jr. Company Use of edible film to improve the packaging of chewing gum
US5536511A (en) * 1994-05-06 1996-07-16 Wm. Wrigley Jr. Company Chewing gum pellet coated with a hard coating containing erythritol and xylitol
US5603970A (en) * 1994-05-06 1997-02-18 Wm. Wrigley Jr. Company Chewing gum pellet coated with a hard coating containing erythritol
US6627233B1 (en) 1997-09-18 2003-09-30 Wm. Wrigley Jr. Company Chewing gum containing physiological cooling agents
US20030082271A1 (en) * 1997-09-18 2003-05-01 Wm. Wrigley, Jr. Company Chewing gum containing controlled release acyclic carboxamides
US20080199565A1 (en) * 1997-09-18 2008-08-21 Wm. Wrigley Jr. Company Chewing Gum Containing Physiological Cooling Agents
US7364761B2 (en) 1997-09-18 2008-04-29 Wm. Wrigley Jr. Company Chewing gum containing physiological cooling agents and method of preparing
US20070202212A1 (en) * 1997-09-18 2007-08-30 Wm. Wrigley Jr. Company Chewing gum containing controlled release acyclic carboxamides
US20040247743A1 (en) * 1997-09-18 2004-12-09 Wm. Wrigley, Jr. Company Chewing gum containing physiological cooling agents
US20070098842A1 (en) * 1997-09-18 2007-05-03 Wm. Wrigley Jr. Company Chewing gum containing physiological cooling agents
US20050019445A1 (en) * 1997-09-18 2005-01-27 Wm. Wrigley Jr. Company Chewing gum containing physiological cooling agents
US7078066B2 (en) 1997-09-18 2006-07-18 Wm. Wrigley Jr. Company Chewing gum containing physiological cooling agents and method of making
US6455080B1 (en) 1997-12-29 2002-09-24 Wm. Wrigley Jr., Company Chewing gum containing controlled release acyclic carboxamide and method of making
US6506424B2 (en) 2000-05-22 2003-01-14 Dandy Sakiz Ve Sekerleme Sanayi A.S. Multicolored chewing gum with crunchy transparent coating
GB2420958B (en) * 2002-07-23 2007-04-25 Mars Inc Foodstuff
WO2004008877A1 (en) * 2002-07-23 2004-01-29 Mars Incorporated Polyol coated food products
WO2004008878A1 (en) * 2002-07-23 2004-01-29 Mars, Incorporated Barrier layer based on polyol
EP1757193A3 (de) * 2002-07-23 2007-05-16 Mars Incorporated Polyolbeschichtete Lebensmittel
US20070048418A1 (en) * 2002-07-23 2007-03-01 Mars, Incorporated Polyol coated food product
GB2391449B (en) * 2002-07-23 2006-05-17 Mars Inc Foodstuff
GB2420958A (en) * 2002-07-23 2006-06-14 Mars Inc Foodstuff coated with one or more molten polyols
EP1757193A2 (de) * 2002-07-23 2007-02-28 Mars Incorporated Polyolbeschichtete Lebensmittel
US20060198924A1 (en) * 2002-08-14 2006-09-07 Joo Song Methods for manufacturing coated confectionery products
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Also Published As

Publication number Publication date
JPS5725007B2 (de) 1982-05-27
DE2636152B1 (de) 1977-10-06
AU2768777A (en) 1979-02-15
HU176597B (en) 1981-03-28
ATA584277A (de) 1979-03-15
JPS5320416A (en) 1978-02-24
CH630259A5 (de) 1982-06-15
SE7709050L (sv) 1978-02-12
IT1086479B (it) 1985-05-28
FR2361105A1 (fr) 1978-03-10
CA1086650A (en) 1980-09-30
AU510921B2 (en) 1980-07-17
DE2636152C2 (de) 1980-11-06
GB1547527A (en) 1979-06-20
NL7708808A (de) 1978-02-14
SE431935B (sv) 1984-03-12
ES461516A1 (es) 1978-07-16
BE857659A (fr) 1977-12-01
FR2361105B1 (de) 1981-06-19
AT352884B (de) 1979-10-10

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