US3926734A - Urea analysis - Google Patents

Urea analysis Download PDF

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Publication number
US3926734A
US3926734A US427322A US42732273A US3926734A US 3926734 A US3926734 A US 3926734A US 427322 A US427322 A US 427322A US 42732273 A US42732273 A US 42732273A US 3926734 A US3926734 A US 3926734A
Authority
US
United States
Prior art keywords
urea
urease
membrane
hydrolysis
ammonia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US427322A
Other languages
English (en)
Inventor
Don N Gray
Melvin H Keyes
Frank E Semersky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
OI Glass Inc
Original Assignee
Owens Illinois Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Owens Illinois Inc filed Critical Owens Illinois Inc
Priority to US427322A priority Critical patent/US3926734A/en
Priority to FR7438065A priority patent/FR2255602B1/fr
Priority to NLAANVRAGE7415252,A priority patent/NL176308C/xx
Priority to DE2455970A priority patent/DE2455970C3/de
Priority to CA214,867A priority patent/CA1039163A/en
Priority to GB54031/74A priority patent/GB1494490A/en
Priority to JP14436174A priority patent/JPS5330035B2/ja
Priority to AU76761/74A priority patent/AU481620B2/en
Application granted granted Critical
Publication of US3926734A publication Critical patent/US3926734A/en
Assigned to TECHNICON INSTRUMENTS CORPORATION reassignment TECHNICON INSTRUMENTS CORPORATION MERGER (SEE DOCUMENT FOR DETAILS). Assignors: REVGROUP PANTRY MIRROR CORP.
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/58—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving urea or urease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48742—Determining urea by measuring the volume of a gas
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/807—Gas detection apparatus

Definitions

  • hydrolysis zone comprises a bed of urease immobilized on a solid support.
  • aqueous specimen containing urea is an aqueous solution buffered to a pH in the range of about 5 to 9.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
US427322A 1973-12-21 1973-12-21 Urea analysis Expired - Lifetime US3926734A (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
US427322A US3926734A (en) 1973-12-21 1973-12-21 Urea analysis
FR7438065A FR2255602B1 (enrdf_load_stackoverflow) 1973-12-21 1974-11-20
NLAANVRAGE7415252,A NL176308C (nl) 1973-12-21 1974-11-22 Werkwijze en inrichting voor het potentiometrisch bepalen van ureum in een waterige vloeistof.
DE2455970A DE2455970C3 (de) 1973-12-21 1974-11-27 Verfahren und Vorrichtung zur Analyse von Harnstoff
CA214,867A CA1039163A (en) 1973-12-21 1974-11-28 Urea analysis
GB54031/74A GB1494490A (en) 1973-12-21 1974-12-13 Urea analysis
JP14436174A JPS5330035B2 (enrdf_load_stackoverflow) 1973-12-21 1974-12-16
AU76761/74A AU481620B2 (en) 1973-12-21 1974-12-23 Urea analysis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US427322A US3926734A (en) 1973-12-21 1973-12-21 Urea analysis

Publications (1)

Publication Number Publication Date
US3926734A true US3926734A (en) 1975-12-16

Family

ID=23694363

Family Applications (1)

Application Number Title Priority Date Filing Date
US427322A Expired - Lifetime US3926734A (en) 1973-12-21 1973-12-21 Urea analysis

Country Status (7)

Country Link
US (1) US3926734A (enrdf_load_stackoverflow)
JP (1) JPS5330035B2 (enrdf_load_stackoverflow)
CA (1) CA1039163A (enrdf_load_stackoverflow)
DE (1) DE2455970C3 (enrdf_load_stackoverflow)
FR (1) FR2255602B1 (enrdf_load_stackoverflow)
GB (1) GB1494490A (enrdf_load_stackoverflow)
NL (1) NL176308C (enrdf_load_stackoverflow)

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE30267E (en) * 1975-06-20 1980-05-06 Eastman Kodak Company Multilayer analytical element
US4223089A (en) * 1978-05-17 1980-09-16 Boehringer Mannheim Gmbh Process and diagnostic device for the determination of ammonia and of substrates which react with the formation of ammonia
WO1981000304A1 (en) * 1979-07-24 1981-02-05 I Lundstroem A method and apparatus for indicating the presence of substances which,in a chemical reaction,generate or consume gas
EP0071152A1 (de) * 1981-07-29 1983-02-09 Siemens Aktiengesellschaft Verfahren und Vorrichtung zur Bestimmung von Harnstoff
EP0299660A3 (en) * 1987-07-17 1990-09-12 INSTRUMENTATION LABORATORY S.p.A. Sample analysis
DE4027728A1 (de) * 1990-08-31 1992-03-05 Bayer Ag Immobilisierung von organischen makromolekuelen oder biopolymeren in einer polymermembran
US5133937A (en) * 1989-06-01 1992-07-28 Iniziative Marittime, 1991 S.R.L. Analysis system having a removable reaction cartridge and temperature control
US5158868A (en) * 1987-07-17 1992-10-27 Iniziative Marittime 1991, S.R.L. Method of sample analysis
US5685988A (en) * 1993-09-15 1997-11-11 Malchesky; Paul Dialysis process and system
US5721111A (en) * 1994-10-13 1998-02-24 Kyowa Medex Co., Ltd. Method for determination of urea nitrogen
WO2003048382A1 (en) * 2001-12-03 2003-06-12 Sievers Instruments, Inc. Sensitive detection of urea and related compounds in water
US20120258545A1 (en) * 2011-04-06 2012-10-11 Ash Stephen R Measuring chemical properties of a sample fluid in dialysis systems
US8882988B2 (en) 2012-12-26 2014-11-11 Umm Al-Qura University Potentiometric device and method selective for pioglitazone
EP3737938A4 (en) * 2018-01-12 2021-06-23 Mayo Foundation for Medical Education and Research SYSTEMS AND METHODS FOR DETECTION AND QUANTIFICATION OF AMMONIA AND AMMONIUM IN LIQUIDS
WO2021234434A1 (en) * 2020-05-19 2021-11-25 Ecole Polytechnique Federale De Lausanne (Epfl) Method and system for producing a carbonate-containing species-rich, nitrogen-containing species-free solution
US20220146477A1 (en) * 2020-11-10 2022-05-12 Acustrip Company, Inc. Method and kit for detecting diesel exhaust fluid in fuel

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5786053A (en) * 1980-11-18 1982-05-28 Yokogawa Hokushin Electric Corp Method and device for measuring amino compound
JPS5839947A (ja) * 1981-09-03 1983-03-08 Yokogawa Hokushin Electric Corp 尿素の測定方法および測定装置
JPS5858457A (ja) * 1981-09-30 1983-04-07 Shimadzu Corp 溶液導電率型ガス濃度測定用電極
JPS5877663A (ja) * 1981-11-02 1983-05-11 Kyoto Daiichi Kagaku:Kk 尿素分析方法および分析用具
DK364189A (da) * 1988-07-25 1990-01-26 Nova Biomedical Corp Sensor
DE3841623A1 (de) * 1988-12-10 1990-06-13 Draegerwerk Ag Dosimeter mit wiederverwendbarer elektrochemischer messzelle
ES2102936B1 (es) * 1994-03-02 1998-04-01 Estudios E Invest Del Agua Metodo de medicion de la concentracion de amonio total en medio liquido y dispositivo para la realizacion del mismo.

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3395082A (en) * 1964-07-20 1968-07-30 Miles Lab Test composition device and method for detecting urea in aqueous fluids
US3649505A (en) * 1969-03-03 1972-03-14 Beckman Instruments Inc Ammonia sensor
US3838011A (en) * 1971-06-18 1974-09-24 Boehringer Mannheim Gmbh Process and apparatus for the quantitative determination of an enzymatically reactive substance

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3395082A (en) * 1964-07-20 1968-07-30 Miles Lab Test composition device and method for detecting urea in aqueous fluids
US3649505A (en) * 1969-03-03 1972-03-14 Beckman Instruments Inc Ammonia sensor
US3838011A (en) * 1971-06-18 1974-09-24 Boehringer Mannheim Gmbh Process and apparatus for the quantitative determination of an enzymatically reactive substance

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE30267E (en) * 1975-06-20 1980-05-06 Eastman Kodak Company Multilayer analytical element
US4223089A (en) * 1978-05-17 1980-09-16 Boehringer Mannheim Gmbh Process and diagnostic device for the determination of ammonia and of substrates which react with the formation of ammonia
WO1981000304A1 (en) * 1979-07-24 1981-02-05 I Lundstroem A method and apparatus for indicating the presence of substances which,in a chemical reaction,generate or consume gas
EP0071152A1 (de) * 1981-07-29 1983-02-09 Siemens Aktiengesellschaft Verfahren und Vorrichtung zur Bestimmung von Harnstoff
US4505784A (en) * 1981-07-29 1985-03-19 Siemens Aktiengesellschaft Method for urea analysis
EP0299660A3 (en) * 1987-07-17 1990-09-12 INSTRUMENTATION LABORATORY S.p.A. Sample analysis
US4997627A (en) * 1987-07-17 1991-03-05 Fisher Scientific Company Sample analysis
US5158868A (en) * 1987-07-17 1992-10-27 Iniziative Marittime 1991, S.R.L. Method of sample analysis
US5133937A (en) * 1989-06-01 1992-07-28 Iniziative Marittime, 1991 S.R.L. Analysis system having a removable reaction cartridge and temperature control
DE4027728A1 (de) * 1990-08-31 1992-03-05 Bayer Ag Immobilisierung von organischen makromolekuelen oder biopolymeren in einer polymermembran
US5685988A (en) * 1993-09-15 1997-11-11 Malchesky; Paul Dialysis process and system
US5721111A (en) * 1994-10-13 1998-02-24 Kyowa Medex Co., Ltd. Method for determination of urea nitrogen
WO2003048382A1 (en) * 2001-12-03 2003-06-12 Sievers Instruments, Inc. Sensitive detection of urea and related compounds in water
US20050106650A1 (en) * 2001-12-03 2005-05-19 Godec Richard D. Sensitive detection of urea and related compounds in water
US7662637B2 (en) 2001-12-03 2010-02-16 Ge Analytical Instruments Sensitive detection of urea and related compounds in water
US20120258545A1 (en) * 2011-04-06 2012-10-11 Ash Stephen R Measuring chemical properties of a sample fluid in dialysis systems
US8945936B2 (en) * 2011-04-06 2015-02-03 Fresenius Medical Care Holdings, Inc. Measuring chemical properties of a sample fluid in dialysis systems
US9599599B2 (en) 2011-04-06 2017-03-21 Fresenius Medical Care Holdings, Inc. Measuring chemical properties of a sample fluid in dialysis systems
US8882988B2 (en) 2012-12-26 2014-11-11 Umm Al-Qura University Potentiometric device and method selective for pioglitazone
EP3737938A4 (en) * 2018-01-12 2021-06-23 Mayo Foundation for Medical Education and Research SYSTEMS AND METHODS FOR DETECTION AND QUANTIFICATION OF AMMONIA AND AMMONIUM IN LIQUIDS
US11793431B2 (en) 2018-01-12 2023-10-24 Mayo Foundation For Medical Education And Research Systems and methods for the detection and quantification of ammonia and ammonium in fluids
US12178575B2 (en) 2018-01-12 2024-12-31 Mayo Foundation For Medical Education And Research Systems and methods for the detection and quantification of ammonia and ammonium in fluids
US12357205B2 (en) 2018-01-12 2025-07-15 Mayo Foundation For Medical Education And Research Systems and methods for the detection and quantification of ammonia and ammonium in fluids
WO2021234434A1 (en) * 2020-05-19 2021-11-25 Ecole Polytechnique Federale De Lausanne (Epfl) Method and system for producing a carbonate-containing species-rich, nitrogen-containing species-free solution
US20220146477A1 (en) * 2020-11-10 2022-05-12 Acustrip Company, Inc. Method and kit for detecting diesel exhaust fluid in fuel
US11726070B2 (en) * 2020-11-10 2023-08-15 Acustrip Company, Inc. Method and kit for detecting diesel exhaust fluid in fuel
US12078626B2 (en) 2020-11-10 2024-09-03 Acustrip Company, Inc. Method and kit for detecting diesel exhaust fluid in fuel

Also Published As

Publication number Publication date
NL176308C (nl) 1985-03-18
GB1494490A (en) 1977-12-07
CA1039163A (en) 1978-09-26
JPS5098396A (enrdf_load_stackoverflow) 1975-08-05
FR2255602B1 (enrdf_load_stackoverflow) 1978-06-16
JPS5330035B2 (enrdf_load_stackoverflow) 1978-08-24
FR2255602A1 (enrdf_load_stackoverflow) 1975-07-18
AU7676174A (en) 1976-06-24
DE2455970A1 (de) 1975-07-03
DE2455970B2 (de) 1977-07-21
NL7415252A (nl) 1975-06-24
DE2455970C3 (de) 1978-03-02
NL176308B (nl) 1984-10-16

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Legal Events

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AS Assignment

Owner name: TECHNICON INSTRUMENTS CORPORATION

Free format text: MERGER;ASSIGNOR:REVGROUP PANTRY MIRROR CORP.;REEL/FRAME:004912/0740

Effective date: 19871231