US3895022A - Anti-inflammatory agents, cosmetic preparations and method of preventing inflammation - Google Patents

Anti-inflammatory agents, cosmetic preparations and method of preventing inflammation Download PDF

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Publication number
US3895022A
US3895022A US318757A US31875772A US3895022A US 3895022 A US3895022 A US 3895022A US 318757 A US318757 A US 318757A US 31875772 A US31875772 A US 31875772A US 3895022 A US3895022 A US 3895022A
Authority
US
United States
Prior art keywords
benzoxazole
carboxylic acid
ester
melting point
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US318757A
Other languages
English (en)
Inventor
Hinrich Moller
Christian Gloxhuber
Harald Schnegelberger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Henkel AG and Co KGaA
Original Assignee
Henkel AG and Co KGaA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Henkel AG and Co KGaA filed Critical Henkel AG and Co KGaA
Application granted granted Critical
Publication of US3895022A publication Critical patent/US3895022A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/002—Aftershave preparations

Definitions

  • EXAMPLE 1 Di-ethanolammonium salt of 5-methoxybenzoxazole-2-carboxylic acid 7.8 gm of 5-methoxy-benzoxazole-2-carboxylic acid were stirred in ml of methanol with 5.0 gm of diethanolamine at room temperature. The methanol was distilled off from the solution formed, the oily residue was taken up in a little acetone, cooled to 0to 5C, and the di-ethanolammonium salt which crystallized out was filtered off. 9.7 gm (80.5% of theory) of the salt of melting point 95-99C were obtained.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Cosmetics (AREA)
  • Plural Heterocyclic Compounds (AREA)
US318757A 1971-12-27 1972-12-27 Anti-inflammatory agents, cosmetic preparations and method of preventing inflammation Expired - Lifetime US3895022A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2164851A DE2164851A1 (de) 1971-12-27 1971-12-27 Entzuendungshemmer fuer kosmetische praeparationen

Publications (1)

Publication Number Publication Date
US3895022A true US3895022A (en) 1975-07-15

Family

ID=5829372

Family Applications (1)

Application Number Title Priority Date Filing Date
US318757A Expired - Lifetime US3895022A (en) 1971-12-27 1972-12-27 Anti-inflammatory agents, cosmetic preparations and method of preventing inflammation

Country Status (9)

Country Link
US (1) US3895022A (es)
JP (1) JPS4872340A (es)
BE (1) BE793341A (es)
BR (1) BR7209119D0 (es)
DE (1) DE2164851A1 (es)
ES (3) ES410019A1 (es)
FR (1) FR2165996B1 (es)
GB (1) GB1405776A (es)
NL (1) NL7216060A (es)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4116928A (en) * 1974-07-01 1978-09-26 Eastman Kodak Company Heterocylic ester, ultraviolet stabilizers and their use in organic compositions
US4298742A (en) * 1980-05-12 1981-11-03 Usv Pharmaceutical Corporation Esters of benzoxa(thia)zole-2-carboxylic acids
DE3102907A1 (de) * 1980-03-19 1982-04-08 Hokko Chemical Industry Co. Ltd., Tokyo "benzoxazolonderivate, verfahren zur herstellung derselben sowie zubereitungen, die diese derivate enthalten"
US4405633A (en) * 1982-03-01 1983-09-20 Usv Pharmaceutical Corporation Method of treatment of asthma
US4620010A (en) * 1984-03-29 1986-10-28 Usv Pharmaceutical Corp. Process for preparing carboalkoxy substituted benzoxazole compounds

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3641029A (en) * 1970-02-02 1972-02-08 American Cyanamid Co Substituted benzoxazolecarboxamides and benzothiazolecarboxamides

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3641029A (en) * 1970-02-02 1972-02-08 American Cyanamid Co Substituted benzoxazolecarboxamides and benzothiazolecarboxamides

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4116928A (en) * 1974-07-01 1978-09-26 Eastman Kodak Company Heterocylic ester, ultraviolet stabilizers and their use in organic compositions
DE3102907A1 (de) * 1980-03-19 1982-04-08 Hokko Chemical Industry Co. Ltd., Tokyo "benzoxazolonderivate, verfahren zur herstellung derselben sowie zubereitungen, die diese derivate enthalten"
US4298742A (en) * 1980-05-12 1981-11-03 Usv Pharmaceutical Corporation Esters of benzoxa(thia)zole-2-carboxylic acids
US4405633A (en) * 1982-03-01 1983-09-20 Usv Pharmaceutical Corporation Method of treatment of asthma
US4620010A (en) * 1984-03-29 1986-10-28 Usv Pharmaceutical Corp. Process for preparing carboalkoxy substituted benzoxazole compounds

Also Published As

Publication number Publication date
JPS4872340A (es) 1973-09-29
GB1405776A (en) 1975-09-10
FR2165996B1 (es) 1975-11-28
BE793341A (fr) 1973-06-27
DE2164851A1 (de) 1973-07-05
BR7209119D0 (pt) 1973-11-01
FR2165996A1 (es) 1973-08-10
ES410018A1 (es) 1975-12-01
ES410017A1 (es) 1975-12-01
ES410019A1 (es) 1975-12-01
NL7216060A (es) 1973-06-29

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