US3892237A - Self-injecting syringe - Google Patents

Self-injecting syringe Download PDF

Info

Publication number
US3892237A
US3892237A US461605A US46160574A US3892237A US 3892237 A US3892237 A US 3892237A US 461605 A US461605 A US 461605A US 46160574 A US46160574 A US 46160574A US 3892237 A US3892237 A US 3892237A
Authority
US
United States
Prior art keywords
ampoule
casing
needle
liquid
canal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US461605A
Other languages
English (en)
Inventor
Maurice Steiner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of US3892237A publication Critical patent/US3892237A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2053—Media being expelled from injector by pressurised fluid or vacuum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2422—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
    • A61M5/2425—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule by compression of deformable ampoule or carpule wall
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
    • B67B—APPLYING CLOSURE MEMBERS TO BOTTLES JARS, OR SIMILAR CONTAINERS; OPENING CLOSED CONTAINERS
    • B67B7/00—Hand- or power-operated devices for opening closed containers
    • B67B7/92—Hand- or power-operated devices for opening closed containers by breaking, e.g. for ampoules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3145—Filters incorporated in syringes

Definitions

  • the present invention relates to injecting devices of the type comprising, on the one hand, a glass ampoule with a breakable tip containing a liquid to be injected and compressed gas, and, on the other hand, an hypodermic needle and communicating means between said needle and said glass ampoule.
  • the purpose of the present invention is an automatic working injection device preventing any risk for the patient and ensuring the stability and the purity of the conditioned product.
  • the injecting device comprises a protecting casing, and inside this casing an empty plastics ampoule, a needle fitted onto said empty ampoule in such a manner that its canal is opening into said empty ampoule, a glass ampoule sealed inside the casing and containing the liquid to be injected, means to break the end of the glass am poule, means to provide for the filling of the ampoule of plastic material with the liquid coming out of the glass ampoule, mechanical resilient means for ejecting through the needle the liquid of the plastics ampoule after it has been filled up compressioning means for said mechanical resilient means and, outside said casing, means for releasing said resilient means.
  • FIG. 1 is a longitudinal section view of a first embodiment of the syringe.
  • FIG. 2 is a detailed view of a modification of the device in FIG. 1.
  • FIG. 3 is a detailed elevation view of a member in FIG. 2.
  • FIG. 4 is a plan view of the member in FIG. 3.
  • FIG. 5 is a longitudinal section view of another em bodiment of the syringe according to the invention and FIG. 6 is a plan view of a member of the syringe in FIG. 5.
  • the syringe comprises a cylindrical casing, preferably of plastics, made of two parts, screwed for example, 1 and 2; the upper part 1 contains a tensioned spring 3 bearing, on the one hand, against the bottom of the casing, and on the other hand, against a member 11 of plastics material, the purpose of which will be explained hereafter.
  • This ampoule is of the selfbreaking type, i.e., to break its neck 7, it is but necessary to apply a pressure at its level.
  • the liquid to be injected is contained in this ampoule together with a certain quantity 8 of compressed gas.
  • the end of the ampoule is capped with a tightly fitted pipe 10, made of rubber or similar material.
  • This pipe is fitted at its lower end, onto the cylindrical projection provided therefor on the plastics member 11, the socalled piston, which is sliding with some play in the casing 2.
  • a small filter 33 a cotton one for example, is arranged in the space provided between the tip 7 of the glass ampoule 5 and the member 11, so as to prevent, in the case when the breaking of the tip would result in glass spliting, the splits from being carried on into the ampoule l6.
  • the piston 11 comprises a canal l2 and a valve 13 of the ball type.
  • a frusto-conical member 14 is positioned, but not tightly fitted, in the corresponding frusto-conical part 15 of a plastics ampoule 16 having an accordion shape.
  • the latter is fitted onto the support 17 of a bevelled needle 18 which is tightly engaged by friction, so as to ensure tightness, into a rubber stopper 19 which can be perforated and is accommodated in an opening provided at the lower portion of the casing.
  • the lower external portion 22 of casing 2 comprises a threading and two openings, having the shape of narrow slots diametrically opposite, are provided on the same member.
  • Member 24 has two lugs 26, 26' engaging the two slots 25. These two lugs are protruding inside the casing 2, sufficiently to stop the stroke of piston 11.
  • the protecting tube of ampoule 6 is stopped by a disc fitted therein 27 which is in contact with the end of a pusher 28 covering the upper end of the syringe and passing through the bottom of the latter.
  • This pusher shall necessarily be locked during the transport of the syringe by the user.
  • the locking means is not shown on the drawing; this could be a mere pin.
  • the filter 33 is applied to the upper part which is in a bevelled position 29 of member 11.
  • the releasing device of the type described in the US. Pat. No. 3,702,609 comprises hook-shaped members 30 and a ring 31.
  • the ends 32, 32' of members 30 are holding the lower portion of member 11.
  • the upper part of the syringe is grasped, and by applying uprightly the lower part onto a hard object, having an approximately horizontal part, and if necessary onto the ground, with interposition of a handkerchief, a sudden thrust is impelled to the pusher with the hand palm.
  • the neck 7 is submitted to a force perpendicular to the axis, owing to the pitch of the upper face 29 of piston 11 and it breaks.
  • the screwing or unscrewing of nut 23 enables the dose ofliquid to be injected to be determined by adjustment of the length of the piston stroke.
  • slots 25 permit to ascertain that the ampoule 16 is satisfactorily filled up during the operation.
  • the ball-valve in FIG. 1 is replaced by a merely mechanical means preferably of plastics made of a blade 34 comprising a narrow portion 35, called guide, a circular opening 36 of the same diameter as canal 12 of the member 29, a vent 37 and an end portion 38 with a flat-spring shape.
  • This blade 34 is acting as a slide" and is housed by soft friction into a groove of same profile provided in the thickness of member 29.
  • the portion 35 engages a slide provided in the thickness of the syringe wall.
  • This slide 39 may, if desired, be provided in a thickening of same wall. its profile constituting, in the plastics molding technics, a counter-stripping" arrangement, this slide may be housed at the level of the connecting face of the two syringe portions.
  • the spring portion of the slide maintains the latter in a pre-determined position, i.e., with its opening 36 fit ting exactly canal l2, and with its vent 37 freeing a small canal 40 which enables the compressed gas to escape during the liquid transfer.
  • plastics ampoule is conveniently filled up, which is easy to obtain, as it is but necessary to provide for a quantity of liquid slightly in excess in the glass ampoule and the liquid contained in this ampoule will not escape, whatever the position of the syringe, due to the capillarity forces.
  • the syringe differs only from that in FIG. 1 by the use of a releasing device 4 ensuring the breaking of tip 7 of the glass ampoule 5 as well as the releasing of spring 3.
  • This spring is here bearing on the one hand against the bottom of casing 1 and on the other hand against this member 4.
  • This releasing device 4 has the shape of a fork, the two legs of which are gripping the combined tip 7 of the glass ampoule 5 and rubber pipe 10.
  • a canal 21 is provided near the grasping ring 32 of the releasing device 4.
  • the user presses down the releasing device until it is flush with casing l, in taking hold ofit through ring 32.
  • the end 7 of the ampoule is broken.
  • the gas 8 urges the liquid into the ampoule l6, emptying the glass ampoule, and escapes outwards through the space provided for by the clearance between the piston ll and the wall, and through the canal 21 connecting the inside of the syringe to the outside.
  • the user waits a few seconds and then applies the bottom of the syringe to his body; he pulls off then the releasing device 4 by pulling on ring 32.
  • An injecting device comprising a protecting casing, and inside this casing an empty plastics collapsible ampoule, a needle having a canal and fitted onto said empty ampoule, said needle canal opening into said empty ampoule, a glass ampoule sealed inside the casing and containing the liquid to be injected, means to break the end of the glass ampoule, means to provide for the filling of the collapsible ampoule with the liquid coming out of the glass ampoule, mechanical resilient means for both propelling said needle through said casing and ejecting through said needle the liquid of the collapsible ampoule by compressing said collapsible ampoule after it has been filled up, compressioning means for said mechanical resilient means, and outside said casing, means for releasing said resilient means.
  • said means to provide for the filling of the collapsible ampoule comprises an obturating member for said empty ampoule slidably mounted in said casing and having an axial canal, a blade slidingly mounted in said obturating member and provided with a hole aligned with said axial canal, means urging said blade towards the outside of said obturating member, and means for urging said blade towards the inside of said obturating member when said resilient means are released.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mechanical Engineering (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
US461605A 1973-07-17 1974-04-17 Self-injecting syringe Expired - Lifetime US3892237A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7326167A FR2237643B1 (es) 1973-07-17 1973-07-17

Publications (1)

Publication Number Publication Date
US3892237A true US3892237A (en) 1975-07-01

Family

ID=9122714

Family Applications (1)

Application Number Title Priority Date Filing Date
US461605A Expired - Lifetime US3892237A (en) 1973-07-17 1974-04-17 Self-injecting syringe

Country Status (3)

Country Link
US (1) US3892237A (es)
DE (1) DE2431347A1 (es)
FR (1) FR2237643B1 (es)

Cited By (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4772271A (en) * 1985-08-13 1988-09-20 Medicorp Holding S.A. Prefilled syringe
USRE32922E (en) * 1983-01-13 1989-05-16 Paul D. Levin Blood sampling instrument
AU614264B2 (en) * 1986-07-01 1991-08-29 Schluter, Eberhardt Automatic injection device, and ampoule or cartridge for an injection device
WO1994006690A1 (en) * 1992-09-21 1994-03-31 Habley Medical Technology Corporation Device and method for containing an ampule and transferring liquid within the ampule to a container
US5301381A (en) * 1992-12-07 1994-04-12 Klupt Michael F Toothbrush system
EP0694498A1 (de) 1994-07-28 1996-01-31 AVL Medical Instruments AG Verfahren und Vorrichtung zur Entnahme einer Flüssigkeit aus einer verschlossenen Glasampulle
US5540709A (en) * 1991-11-12 1996-07-30 Actimed Laboratories, Inc. Lancet device
US5683369A (en) * 1994-04-12 1997-11-04 Tsukada Medical Research Co., Ltd. Bellows type container charged with liquid medicine
US5879336A (en) * 1995-03-13 1999-03-09 Vygon Device for injecting a liquid
US5948366A (en) * 1997-11-24 1999-09-07 Avl Medical Instruments Ag Glass ampoule for holding a drug a calibration liquid or a quality control liquid
JP2981616B2 (ja) 1997-12-22 1999-11-22 アー・ファウ・エル・メディカル・インスツルメンツ・アー・ゲー ガラスアンプルからその内容物を取り出すための装置
US6047865A (en) * 1996-07-24 2000-04-11 The Boc Group Plc Gas capsule and gas delivery system
EP1017485A1 (en) * 1997-07-29 2000-07-12 Stryker Technologies Corporation Apparatus for storing, mixing, and dispensing two-component bone cement
US6099532A (en) * 1998-07-13 2000-08-08 Howmedica Inc. Disposable monomer dispenser and vial breaker
GB2352233A (en) * 1999-07-17 2001-01-24 Anant Mohanal Ghelani Vial handling device
WO2001017590A1 (en) * 1999-09-09 2001-03-15 Tri-Med International, Llc Multiple-dose syringe
US6302868B1 (en) * 1998-12-22 2001-10-16 Owais Mohammad Retractable hypodermic needle assembly and method of making the same
US6379337B1 (en) * 1998-12-22 2002-04-30 Owais Mohammad M. B. B. S. Retractable safety needles for medical applications
US6391003B1 (en) 1999-10-25 2002-05-21 Antares Pharma, Inc. Locking mechanism for a jet injector
US6428528B2 (en) 1998-08-11 2002-08-06 Antares Pharma, Inc. Needle assisted jet injector
US20020152565A1 (en) * 2001-04-20 2002-10-24 Klupt Michael F. Toothbrush system with a three-dimensional brushing action and fluid irrigation
US6516977B2 (en) * 1996-02-21 2003-02-11 Kwan-Ho Chan System and method for mixing bone cement
US6669671B1 (en) 1998-12-22 2003-12-30 Owais Mohammad Retractable needle with dual locking mechanisms
US6776775B1 (en) 1999-12-23 2004-08-17 Owais Mohammad Hypodermic syringe needle assembly and method of making the same
US20050107747A1 (en) * 2002-11-22 2005-05-19 Life-Shield Products, Inc. Retractable safe syringe
US20070086932A1 (en) * 2003-07-18 2007-04-19 Hallam David R Air filtration device
US20090057168A1 (en) * 2007-08-31 2009-03-05 Smit Karen L Medical cement monomer ampoule cartridge for storing the ampoule, opening the ampoule and selectively discharging the monomer from the ampoule
WO2010145041A1 (de) * 2009-06-19 2010-12-23 Medmix Systems Ag Vorrichtungen zum befüllen einer mehrfachspritze oder einfachspritze
US20110114212A1 (en) * 2008-07-29 2011-05-19 Medmix Systems Ag Device for opening a closed fluid container
WO2011095478A1 (en) * 2010-02-05 2011-08-11 Sanofi-Aventis Deutschland Gmbh Flexible reservoir for a medicated module
US8162887B2 (en) 2004-06-23 2012-04-24 Abbott Biotechnology Ltd. Automatic injection devices
WO2012077129A3 (en) * 2010-12-06 2012-07-26 Sujoy Kumar Guha Pre-filled single-use syringe
GB2492941A (en) * 2011-03-02 2013-01-23 Owen Mumford Ltd An apparatus for filling a syringe
US20130145727A1 (en) * 2010-07-07 2013-06-13 Heraeus Medical Gmbh Vacuum cementing system
US20130218089A1 (en) * 2010-11-03 2013-08-22 Sanofi-Aventis Deutschland Gmbh Medicated Module for Administering Fixed Dose
US20130226143A1 (en) * 2010-11-03 2013-08-29 Sanofi-Aventis Deutschland Gmbh Medicated Module Having a Collapsible Feature
US20130226080A1 (en) * 2010-11-03 2013-08-29 Sanofi-Aventis Deutschland Gmbh Medicated module for a drug delivery device
WO2013151696A1 (en) * 2012-04-03 2013-10-10 Synthes Usa, Llc Device and method for opening an ampoule
JP2013542790A (ja) * 2010-11-03 2013-11-28 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 薬物送達システム
US8636704B2 (en) 2009-04-29 2014-01-28 Abbvie Biotechnology Ltd Automatic injection device
US8679061B2 (en) 2006-06-30 2014-03-25 Abbvie Biotechnology Ltd Automatic injection device
US8708968B2 (en) 2011-01-24 2014-04-29 Abbvie Biotechnology Ltd. Removal of needle shields from syringes and automatic injection devices
US8758301B2 (en) 2009-12-15 2014-06-24 Abbvie Biotechnology Ltd Firing button for automatic injection device
US20140192611A1 (en) * 2013-01-07 2014-07-10 Kyphon Sarl Bone cement mixing and delivery system with reduced fume exposure
US20140336586A1 (en) * 2011-12-01 2014-11-13 Novo Nordisk A/S Drug Filled Delivery Assembly
US8915889B2 (en) 2008-08-05 2014-12-23 Antares Pharma, Inc. Multiple dosage injector
US8945063B2 (en) 2009-03-20 2015-02-03 Antares Pharma, Inc. Hazardous agent injection system
US9180244B2 (en) 2010-04-21 2015-11-10 Abbvie Biotechnology Ltd Wearable automatic injection device for controlled delivery of therapeutic agents
US9180259B2 (en) 2005-01-24 2015-11-10 Antares Pharma, Inc. Prefilled syringe jet injector
US9186635B2 (en) 2009-03-17 2015-11-17 Stryker Ireland Limited Vacuum mixing device for bone cement and method for mixing bone cement in said device
US9220660B2 (en) 2011-07-15 2015-12-29 Antares Pharma, Inc. Liquid-transfer adapter beveled spike
US9265887B2 (en) 2011-01-24 2016-02-23 Abbvie Biotechnology Ltd. Automatic injection devices having overmolded gripping surfaces
DE102014112043A1 (de) * 2014-08-22 2016-02-25 Heraeus Medical Gmbh Gespannte Öffnungsvorrichtung für Monomerbehälter
US9333309B2 (en) 2002-02-11 2016-05-10 Antares Pharma, Inc. Intradermal injector
US9364611B2 (en) 2012-05-07 2016-06-14 Antares Pharma, Inc. Needle assisted jet injection device having reduced trigger force
US9446195B2 (en) 2011-07-15 2016-09-20 Antares Pharma, Inc. Injection device with cammed ram assembly
US9642774B2 (en) 2011-09-07 2017-05-09 Stryker European Holdings I, Llc Liquid container with predetermined breaking point
US9707354B2 (en) 2013-03-11 2017-07-18 Antares Pharma, Inc. Multiple dosage injector with rack and pinion dosage system
US9744302B2 (en) 2013-02-11 2017-08-29 Antares Pharma, Inc. Needle assisted jet injection device having reduced trigger force
US9808582B2 (en) 2006-05-03 2017-11-07 Antares Pharma, Inc. Two-stage reconstituting injector
US20170348486A1 (en) * 2014-12-29 2017-12-07 Novo Nordisk A/S Drug delivery device with a hydraulic trigger mechanism
US9950125B2 (en) 2012-04-06 2018-04-24 Antares Pharma, Inc. Needle assisted jet injection administration of testosterone compositions
US10342738B2 (en) 2016-01-19 2019-07-09 Biogen Ma, Inc. Medical metering device
US10532157B2 (en) 2016-04-08 2020-01-14 University Of Washington Ampule autoinjector systems and methods
US10806867B2 (en) 2011-01-24 2020-10-20 E3D Agricultural Cooperative Association Ltd. Injector
WO2021150539A1 (en) * 2020-01-22 2021-07-29 University Of Washington Autoinjector air removal apparatus and method of removing air from an autoinjector
US20210244884A1 (en) * 2018-06-14 2021-08-12 Sanofi Device for Administering a Medicinal Liquid by Injection
US11305056B2 (en) 2017-07-14 2022-04-19 Amgen Inc. Needle insertion-retraction system having dual torsion spring system

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3419347A1 (de) * 1984-05-24 1985-11-28 Jörg Dr. 7888 Rheinfelden Jakob Vorrichtung zum ausgeben einer loesung aus einer flasche
EP2098258A1 (fr) * 2008-03-03 2009-09-09 Jean-Denis Rochat Dispositif de distribution d'un liquide d'injection et procédé de fabrication d'une cartouche

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2871856A (en) * 1954-10-27 1959-02-03 Astra Ab Hypodermic syringe
US3400716A (en) * 1964-06-05 1968-09-10 William H. Schultz Multiple dosage hypodermic syringe
US3702609A (en) * 1968-11-21 1972-11-14 Maurice Steiner Hypodermic syringes, in particular self-injecting syringes
US3742948A (en) * 1969-08-25 1973-07-03 Philips Corp Hypodermic syringe with radially movable blocking elements

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1103541A (fr) * 1954-04-21 1955-11-03 Dispositif d'injection
US3506006A (en) * 1968-03-21 1970-04-14 Corning Glass Works Hypodermic syringe

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2871856A (en) * 1954-10-27 1959-02-03 Astra Ab Hypodermic syringe
US3400716A (en) * 1964-06-05 1968-09-10 William H. Schultz Multiple dosage hypodermic syringe
US3702609A (en) * 1968-11-21 1972-11-14 Maurice Steiner Hypodermic syringes, in particular self-injecting syringes
US3742948A (en) * 1969-08-25 1973-07-03 Philips Corp Hypodermic syringe with radially movable blocking elements

Cited By (146)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE32922E (en) * 1983-01-13 1989-05-16 Paul D. Levin Blood sampling instrument
US4772271A (en) * 1985-08-13 1988-09-20 Medicorp Holding S.A. Prefilled syringe
AU614264B2 (en) * 1986-07-01 1991-08-29 Schluter, Eberhardt Automatic injection device, and ampoule or cartridge for an injection device
US5540709A (en) * 1991-11-12 1996-07-30 Actimed Laboratories, Inc. Lancet device
WO1994006690A1 (en) * 1992-09-21 1994-03-31 Habley Medical Technology Corporation Device and method for containing an ampule and transferring liquid within the ampule to a container
US5393497A (en) * 1992-09-21 1995-02-28 Habley Medical Technology Corporation Device for containing and opening a glass ampule and for transferring liquid within the ampule to a container
US5301381A (en) * 1992-12-07 1994-04-12 Klupt Michael F Toothbrush system
US5321866A (en) * 1992-12-07 1994-06-21 Klupt Michael F Toothbrush system
US5683369A (en) * 1994-04-12 1997-11-04 Tsukada Medical Research Co., Ltd. Bellows type container charged with liquid medicine
AT404827B (de) * 1994-07-28 1999-03-25 Avl Verbrennungskraft Messtech Verfahren und vorrichtung zur entnahme einer flüssigkeit aus einer verschlossenen glasampulle
EP0694498A1 (de) 1994-07-28 1996-01-31 AVL Medical Instruments AG Verfahren und Vorrichtung zur Entnahme einer Flüssigkeit aus einer verschlossenen Glasampulle
US5628353A (en) * 1994-07-28 1997-05-13 Avl Medical Instruments Ag Method and device for withdrawing a liquid from a sealed glass ampoule
US5879336A (en) * 1995-03-13 1999-03-09 Vygon Device for injecting a liquid
US6516977B2 (en) * 1996-02-21 2003-02-11 Kwan-Ho Chan System and method for mixing bone cement
US20030155381A1 (en) * 1996-02-21 2003-08-21 Kwan-Ho Chan System and method for mixing bone cement
US6047865A (en) * 1996-07-24 2000-04-11 The Boc Group Plc Gas capsule and gas delivery system
EP1017485A4 (en) * 1997-07-29 2001-08-01 Stryker Technologies Corp DEVICE FOR STORING, MIXING AND DISPENSING TWO-COMPONENT BONE CEMENT
EP1017485A1 (en) * 1997-07-29 2000-07-12 Stryker Technologies Corporation Apparatus for storing, mixing, and dispensing two-component bone cement
US5948366A (en) * 1997-11-24 1999-09-07 Avl Medical Instruments Ag Glass ampoule for holding a drug a calibration liquid or a quality control liquid
US6099510A (en) * 1997-12-22 2000-08-08 Avl Medical Instruments Ag Device for withdrawing a liquid from a sealed glass ampoule
AT406014B (de) * 1997-12-22 2000-01-25 Avl List Gmbh Vorrichtung zur entnahme einer flüssigkeit aus einer glasampulle
JP2981616B2 (ja) 1997-12-22 1999-11-22 アー・ファウ・エル・メディカル・インスツルメンツ・アー・ゲー ガラスアンプルからその内容物を取り出すための装置
US6099532A (en) * 1998-07-13 2000-08-08 Howmedica Inc. Disposable monomer dispenser and vial breaker
AU751864B2 (en) * 1998-07-13 2002-08-29 Stryker Technologies Corporation Disposable monomer dispenser and vial breaker
US6565553B2 (en) 1998-08-11 2003-05-20 Antares Pharma, Inc. Needle assisted jet injector
USRE44847E1 (en) 1998-08-11 2014-04-15 Antares Pharma, Inc. Needle assisted jet injector
US7744582B2 (en) 1998-08-11 2010-06-29 Antares Pharma, Inc. Needle assisted jet injector
US6428528B2 (en) 1998-08-11 2002-08-06 Antares Pharma, Inc. Needle assisted jet injector
US6746429B2 (en) 1998-08-11 2004-06-08 Antares Pharma, Inc. Needle assisted jet injector
US20040220524A1 (en) * 1998-08-11 2004-11-04 Antares Pharma, Inc. Needle assisted jet injector
US6669671B1 (en) 1998-12-22 2003-12-30 Owais Mohammad Retractable needle with dual locking mechanisms
US6379337B1 (en) * 1998-12-22 2002-04-30 Owais Mohammad M. B. B. S. Retractable safety needles for medical applications
US6302868B1 (en) * 1998-12-22 2001-10-16 Owais Mohammad Retractable hypodermic needle assembly and method of making the same
GB2352233B (en) * 1999-07-17 2003-04-09 Anant Mohanal Ghelani Vial handling device
GB2352233A (en) * 1999-07-17 2001-01-24 Anant Mohanal Ghelani Vial handling device
US6270482B1 (en) 1999-09-09 2001-08-07 Tri-Med International, Llc Multiple-dose syringe
WO2001017590A1 (en) * 1999-09-09 2001-03-15 Tri-Med International, Llc Multiple-dose syringe
US6391003B1 (en) 1999-10-25 2002-05-21 Antares Pharma, Inc. Locking mechanism for a jet injector
US6776775B1 (en) 1999-12-23 2004-08-17 Owais Mohammad Hypodermic syringe needle assembly and method of making the same
US6766549B2 (en) 2001-04-20 2004-07-27 Michael F. Klupt Toothbrush system with a three-dimensional brushing action and fluid irrigation
US20020152565A1 (en) * 2001-04-20 2002-10-24 Klupt Michael F. Toothbrush system with a three-dimensional brushing action and fluid irrigation
US9737670B2 (en) 2002-02-11 2017-08-22 Antares Pharma, Inc. Intradermal injector
US9333309B2 (en) 2002-02-11 2016-05-10 Antares Pharma, Inc. Intradermal injector
US7364569B2 (en) * 2002-11-22 2008-04-29 Life Shield Products Inc Retractable safe syringe
US20050107747A1 (en) * 2002-11-22 2005-05-19 Life-Shield Products, Inc. Retractable safe syringe
US7449053B2 (en) 2003-07-18 2008-11-11 David Richard Hallam Air filtration device
US20070086932A1 (en) * 2003-07-18 2007-04-19 Hallam David R Air filtration device
US8211374B2 (en) 2003-07-18 2012-07-03 David Richard Hallam Air cleaning device
US8668670B2 (en) 2004-06-23 2014-03-11 Abbvie Biotechnology Ltd Automatic injection devices
US9017287B2 (en) 2004-06-23 2015-04-28 Abbvie Biotechnology Ltd Automatic injection devices
US8162887B2 (en) 2004-06-23 2012-04-24 Abbott Biotechnology Ltd. Automatic injection devices
US9764090B2 (en) 2004-06-23 2017-09-19 Abbvie Biotechnology Ltd Relating to automatic injection devices
US10478560B2 (en) 2005-01-24 2019-11-19 Antares Pharma, Inc. Prefilled syringe injector
US9629959B2 (en) 2005-01-24 2017-04-25 Antares Pharma, Inc. Prefilled syringe jet injector
US11446441B2 (en) 2005-01-24 2022-09-20 Antares Pharma, Inc. Prefilled syringe injector
US9180259B2 (en) 2005-01-24 2015-11-10 Antares Pharma, Inc. Prefilled syringe jet injector
US9808582B2 (en) 2006-05-03 2017-11-07 Antares Pharma, Inc. Two-stage reconstituting injector
US10688250B2 (en) 2006-05-03 2020-06-23 Antares Pharma, Inc. Two-stage reconstituting injector
US11547808B2 (en) 2006-05-03 2023-01-10 Antares Pharma, Inc. Two-stage reconstituting injector
US9486584B2 (en) 2006-06-30 2016-11-08 Abbvie Biotechnology Ltd. Automatic injection device
US8679061B2 (en) 2006-06-30 2014-03-25 Abbvie Biotechnology Ltd Automatic injection device
US8132959B2 (en) 2007-08-31 2012-03-13 Stryker Corporation Medical cement monomer ampoule cartridge for storing the ampoule, opening the ampoule and selectively discharging the monomer from the ampoule into a mixer
US20090057168A1 (en) * 2007-08-31 2009-03-05 Smit Karen L Medical cement monomer ampoule cartridge for storing the ampoule, opening the ampoule and selectively discharging the monomer from the ampoule
US20110114212A1 (en) * 2008-07-29 2011-05-19 Medmix Systems Ag Device for opening a closed fluid container
US8944107B2 (en) * 2008-07-29 2015-02-03 Medmix Systems Ag Device for opening a closed fluid container
US8915889B2 (en) 2008-08-05 2014-12-23 Antares Pharma, Inc. Multiple dosage injector
US9186635B2 (en) 2009-03-17 2015-11-17 Stryker Ireland Limited Vacuum mixing device for bone cement and method for mixing bone cement in said device
US9999459B2 (en) * 2009-03-17 2018-06-19 Stryker European Holdings I, Llc Vacuum mixing device for bone cement and method for mixing bone cement in said device
US20160045242A1 (en) * 2009-03-17 2016-02-18 Stryker European Holdings I, Llc Vacuum mixing device for bone cement and method for mixing bone cement in said device
US10555954B2 (en) 2009-03-20 2020-02-11 Antares Pharma, Inc. Hazardous agent injection system
US9750881B2 (en) 2009-03-20 2017-09-05 Antares Pharma, Inc. Hazardous agent injection system
US11497753B2 (en) 2009-03-20 2022-11-15 Antares Pharma, Inc. Hazardous agent injection system
US8945063B2 (en) 2009-03-20 2015-02-03 Antares Pharma, Inc. Hazardous agent injection system
US9561328B2 (en) 2009-04-29 2017-02-07 Abbvie Biotechnology Ltd Automatic injection device
US8636704B2 (en) 2009-04-29 2014-01-28 Abbvie Biotechnology Ltd Automatic injection device
WO2010145041A1 (de) * 2009-06-19 2010-12-23 Medmix Systems Ag Vorrichtungen zum befüllen einer mehrfachspritze oder einfachspritze
US9131930B2 (en) 2009-06-19 2015-09-15 Medmix Systems Ag Devices for filling a multi-use syringe or single-use syringe
US8758301B2 (en) 2009-12-15 2014-06-24 Abbvie Biotechnology Ltd Firing button for automatic injection device
US9358342B2 (en) 2010-02-05 2016-06-07 Sanofi-Aventis Deutschland Gmbh Flexible reservoir for a medicated module
CN102753223A (zh) * 2010-02-05 2012-10-24 赛诺菲-安万特德国有限公司 用于含药模块的挠性储存器
CN102753223B (zh) * 2010-02-05 2015-06-24 赛诺菲-安万特德国有限公司 用于含药模块的挠性储存器
WO2011095478A1 (en) * 2010-02-05 2011-08-11 Sanofi-Aventis Deutschland Gmbh Flexible reservoir for a medicated module
AU2011212556B2 (en) * 2010-02-05 2015-02-19 Sanofi-Aventis Deutschland Gmbh Flexible reservoir for a medicated module
US9180244B2 (en) 2010-04-21 2015-11-10 Abbvie Biotechnology Ltd Wearable automatic injection device for controlled delivery of therapeutic agents
US9821117B2 (en) 2010-04-21 2017-11-21 Abbvie Biotechnology Ltd Wearable automatic injection device for controlled delivery of therapeutic agents
US20130145727A1 (en) * 2010-07-07 2013-06-13 Heraeus Medical Gmbh Vacuum cementing system
US9272803B2 (en) * 2010-07-07 2016-03-01 Heraeus Medical Gmbh Vacuum cementing system
US9180253B2 (en) * 2010-11-03 2015-11-10 Sanofi-Aventis Deutschland Gmbh Medicated module for administering fixed dose
US20130226080A1 (en) * 2010-11-03 2013-08-29 Sanofi-Aventis Deutschland Gmbh Medicated module for a drug delivery device
US9238110B2 (en) * 2010-11-03 2016-01-19 Sanofi-Aventis Deutschland Gmbh Medicated module having a collapsible feature
JP2013542790A (ja) * 2010-11-03 2013-11-28 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 薬物送達システム
US20130218089A1 (en) * 2010-11-03 2013-08-22 Sanofi-Aventis Deutschland Gmbh Medicated Module for Administering Fixed Dose
US20130226143A1 (en) * 2010-11-03 2013-08-29 Sanofi-Aventis Deutschland Gmbh Medicated Module Having a Collapsible Feature
GB2500147B (en) * 2010-12-06 2015-03-18 Sujoy Kumar Guha Auto-Destruct, Pre-loaded Syringe
GB2500147A (en) * 2010-12-06 2013-09-11 Sujoy Kumar Guha Pre-filled single-use syringe
WO2012077129A3 (en) * 2010-12-06 2012-07-26 Sujoy Kumar Guha Pre-filled single-use syringe
GB2503815B (en) * 2010-12-06 2015-03-18 Sujoy Kumar Guha Auto-destruct, pre-loaded syringe
GB2503815A (en) * 2010-12-06 2014-01-08 Sujoy Kumar Guha Auto-destruct, pre-loaded syringe
US9339610B2 (en) 2011-01-24 2016-05-17 Abbvie Biotechnology Ltd Removal of needle shield from syringes and automatic injection devices
US10022503B2 (en) 2011-01-24 2018-07-17 Abbvie Biotechnology Ltd Removal of needle shield from syringes and automatic injection devices
US8708968B2 (en) 2011-01-24 2014-04-29 Abbvie Biotechnology Ltd. Removal of needle shields from syringes and automatic injection devices
US9878102B2 (en) 2011-01-24 2018-01-30 Abbvie Biotechnology Ltd. Automatic injection devices having overmolded gripping surfaces
US9265887B2 (en) 2011-01-24 2016-02-23 Abbvie Biotechnology Ltd. Automatic injection devices having overmolded gripping surfaces
US10806867B2 (en) 2011-01-24 2020-10-20 E3D Agricultural Cooperative Association Ltd. Injector
US11565048B2 (en) 2011-01-24 2023-01-31 Abbvie Biotechnology Ltd. Automatic injection devices having overmolded gripping surfaces
GB2492941A (en) * 2011-03-02 2013-01-23 Owen Mumford Ltd An apparatus for filling a syringe
US10568809B2 (en) 2011-07-15 2020-02-25 Ferring B.V. Liquid-transfer adapter beveled spike
US11185642B2 (en) 2011-07-15 2021-11-30 Antares Pharma, Inc. Injection device with cammed ram assembly
US9220660B2 (en) 2011-07-15 2015-12-29 Antares Pharma, Inc. Liquid-transfer adapter beveled spike
US10279131B2 (en) 2011-07-15 2019-05-07 Antares Pharma, Inc. Injection device with cammed RAM assembly
US9446195B2 (en) 2011-07-15 2016-09-20 Antares Pharma, Inc. Injection device with cammed ram assembly
US9642774B2 (en) 2011-09-07 2017-05-09 Stryker European Holdings I, Llc Liquid container with predetermined breaking point
US20140336586A1 (en) * 2011-12-01 2014-11-13 Novo Nordisk A/S Drug Filled Delivery Assembly
US9889258B2 (en) * 2011-12-01 2018-02-13 Novo Nordisk A/S Drug filled delivery assembly
US9556010B2 (en) * 2012-04-03 2017-01-31 DePuy Synthes Products, Inc. Device and method for opening an ampoule
US20150329339A1 (en) * 2012-04-03 2015-11-19 DePuy Synthes Products. LLC Device and method for opening an ampoule
CN104220361B (zh) * 2012-04-03 2017-08-15 新特斯有限责任公司 用于打开安瓿的装置和方法
WO2013151696A1 (en) * 2012-04-03 2013-10-10 Synthes Usa, Llc Device and method for opening an ampoule
CN104220361A (zh) * 2012-04-03 2014-12-17 新特斯有限责任公司 用于打开安瓿的装置和方法
US11771646B2 (en) 2012-04-06 2023-10-03 Antares Pharma, Inc. Needle assisted jet injection administration of testosterone compositions
US9950125B2 (en) 2012-04-06 2018-04-24 Antares Pharma, Inc. Needle assisted jet injection administration of testosterone compositions
US10821072B2 (en) 2012-04-06 2020-11-03 Antares Pharma, Inc. Needle assisted jet injection administration of testosterone compositions
US10357609B2 (en) 2012-05-07 2019-07-23 Antares Pharma, Inc. Needle assisted jet injection device having reduced trigger force
US9364611B2 (en) 2012-05-07 2016-06-14 Antares Pharma, Inc. Needle assisted jet injection device having reduced trigger force
US11446440B2 (en) 2012-05-07 2022-09-20 Antares Pharma, Inc. Needle assisted injection device having reduced trigger force
US9364610B2 (en) 2012-05-07 2016-06-14 Antares Pharma, Inc. Injection device with cammed ram assembly
US10905827B2 (en) 2012-05-07 2021-02-02 Antares Pharma, Inc. Injection device with cammed ram assembly
US20140192611A1 (en) * 2013-01-07 2014-07-10 Kyphon Sarl Bone cement mixing and delivery system with reduced fume exposure
US9480955B2 (en) * 2013-01-07 2016-11-01 Kyphon Sarl Bone cement mixing and delivery system with reduced fume exposure
US9744302B2 (en) 2013-02-11 2017-08-29 Antares Pharma, Inc. Needle assisted jet injection device having reduced trigger force
US11813435B2 (en) 2013-02-11 2023-11-14 Antares Pharma, Inc. Needle assisted injection device having reduced trigger force
US10881798B2 (en) 2013-02-11 2021-01-05 Antares Pharma, Inc. Needle assisted injection device having reduced trigger force
US9707354B2 (en) 2013-03-11 2017-07-18 Antares Pharma, Inc. Multiple dosage injector with rack and pinion dosage system
US10610649B2 (en) 2013-03-11 2020-04-07 Antares Pharma, Inc. Multiple dosage injector with rack and pinion dosage system
US11628260B2 (en) 2013-03-11 2023-04-18 Antares Pharma, Inc. Multiple dosage injector with rack and pinion dosage system
DE102014112043A1 (de) * 2014-08-22 2016-02-25 Heraeus Medical Gmbh Gespannte Öffnungsvorrichtung für Monomerbehälter
US20160051304A1 (en) * 2014-08-22 2016-02-25 Heraeus Medical Gmbh Tensioned opening device for monomer container
US10485598B2 (en) * 2014-08-22 2019-11-26 Heraeus Medical Gmbh Tensioned opening device for monomer container
US11980742B2 (en) * 2014-12-29 2024-05-14 Novo Nordisk A/S Drug delivery device with a hydraulic trigger mechanism
US20170348486A1 (en) * 2014-12-29 2017-12-07 Novo Nordisk A/S Drug delivery device with a hydraulic trigger mechanism
US10342738B2 (en) 2016-01-19 2019-07-09 Biogen Ma, Inc. Medical metering device
US11786662B2 (en) 2016-04-08 2023-10-17 University Of Washington Ampule autoinjector systems and methods
US10532157B2 (en) 2016-04-08 2020-01-14 University Of Washington Ampule autoinjector systems and methods
US11305056B2 (en) 2017-07-14 2022-04-19 Amgen Inc. Needle insertion-retraction system having dual torsion spring system
US20210244884A1 (en) * 2018-06-14 2021-08-12 Sanofi Device for Administering a Medicinal Liquid by Injection
WO2021150539A1 (en) * 2020-01-22 2021-07-29 University Of Washington Autoinjector air removal apparatus and method of removing air from an autoinjector

Also Published As

Publication number Publication date
DE2431347A1 (de) 1975-01-30
FR2237643B1 (es) 1978-03-17
FR2237643A1 (es) 1975-02-14

Similar Documents

Publication Publication Date Title
US3892237A (en) Self-injecting syringe
US4946441A (en) Limited use hypodermic syringe
US3838689A (en) Disposable syringe with slit valve
US3853125A (en) Disposable needleless injector
US4689042A (en) Automatic medicament ingredient mixing and injecting apparatus
US2591706A (en) Plural-compartment admixing hypodermic syringe ampoule for segregated storage of ingredients of liquid medicinal solutions and therapeutic preparations
US4913699A (en) Disposable needleless injection system
US3048171A (en) Intravenous injection device
US4548601A (en) Prepackaged, injectable pharmaceutical and hypodermic needle combination
US3557787A (en) Disposable syringe
KR0138353Y1 (ko) 일회용 주사기
US8372035B2 (en) Disposable injector with manually actuated piston
US3411503A (en) Collapsible mixing syringe with extrusion casing
US3128765A (en) Hypodermic syringe and dose dispenser
US3930499A (en) Hypodermic syringe with parts disposable after use
CZ300270B6 (cs) Bezjehlová injekcní stríkacka pro injekci kapaliny obsažené v predem naplnené ampuli
US3552387A (en) Combination syringe and vial
JPS6136945B2 (es)
US3878846A (en) Hypodermic syringe with parts disposable after use
US2578812A (en) Injection syringe
US3380450A (en) Sterile disposable plastic prefilled syringe
US2971509A (en) Disposable hypodermic syringe
US2578394A (en) Hypodermic syringe
US2526365A (en) Hypodermic syringe
US2704072A (en) Means for making hypodermic injections