US3851436A - Sterilizing and packaging process utilizing gas plasma - Google Patents

Sterilizing and packaging process utilizing gas plasma Download PDF

Info

Publication number
US3851436A
US3851436A US00207487A US20748771A US3851436A US 3851436 A US3851436 A US 3851436A US 00207487 A US00207487 A US 00207487A US 20748771 A US20748771 A US 20748771A US 3851436 A US3851436 A US 3851436A
Authority
US
United States
Prior art keywords
gas plasma
container
article
flow
sterilized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US00207487A
Other languages
English (en)
Inventor
S Fraser
R Gillette
R Olson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boeing Co
Original Assignee
Boeing Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boeing Co filed Critical Boeing Co
Priority to US00207487A priority Critical patent/US3851436A/en
Priority to CA158,654A priority patent/CA1004823A/en
Priority to GB5731772A priority patent/GB1416723A/en
Priority to JP47125102A priority patent/JPS4865796A/ja
Priority to DE2260854A priority patent/DE2260854A1/de
Priority to FR7244406A priority patent/FR2169814B1/fr
Priority to CA183,541A priority patent/CA990925A/en
Application granted granted Critical
Publication of US3851436A publication Critical patent/US3851436A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/14—Plasma, i.e. ionised gases

Definitions

  • This invention relates to the sterilization by the use of coal gas plasma of articles sufficiently fragile so that they cannot be subjected to a high pressure differential or which are made of material that will become plastic ormelt at high temperatures, or which would be damaged if subjected to thermal shock by an abrupt temperature change.
  • a principal object of the present invention is to provide a sterilizing and packaging process in which the sterilizing effectiveness of gas plasma is increased by providing a continued flow of the gas plasma over surfaces to be sterilized with minimum dilution by air.
  • Another object is to cover immediately surfaces which have been sterilized by flow of gas plasma over them so as to preserve their sterile character.
  • F IG. 1 is adiagram of representative sterilizing apparatus utilizing gas plasma according to the present invention. l I
  • FIG. 3 and FIG. 4 are detail elevations of somewhat modified portions of the apparatus shown in-FIG. 2.
  • Sterilization of articles by the process of the present invention is accomplished in a sterilization chamber 1.
  • An article 2 to besterilized is inserted into such chamber through a suitable aperture closable to withstand substantial external pressure.
  • the chamber is provided in a metal casing of cylindrical shape which can be evacuated without collapsing.
  • Gas such as argon from-which the gas plasma is produced is supplied from a tank 3-in which it is stored under pressure through a'flowmeter' 4to the plasma production conduit 5 connected to one end of the sterilization chamber 1.
  • Such 'plasma produ ction conduit is subjected 'to a radio-frequency field created by the electrodes 6, whi ch may'encircle such conduit.
  • a suitable radio-frequency generator 7- is' connected to the electrodes '6 through an impedance matching network 8 for coupling the ,capacitativeelectrodes 6 to an amplifier of the radio-frequency generator 7.
  • the oscillator and amplifier of the radio-frequency generator should be capable of producing up to'3'00 watts of continuous power'as indicated by the power meter 9.
  • the supply of gas to the plasma generator can be regulated by a valve 11 as wellas automatically by the flowmeter 4; and the flowmeter pressure gauge 12 will indicate the amount of gas supplied to the plasma-generating tube 5.
  • the quantity of gasplasma flowing through the'sterilization chamber 1 is determined, not only by the flow meter 4 and the valve 11, but also by the pressure in the sterilization chamber 1 through which the plasma flows.
  • the pressure in such sterilization chamber is preferably quite low, not exceeding a few millimeters of mercury.
  • the pressure in'the sterilization chamber could'be indicatedby a pressure gauge 14.
  • the supply of gas to the plasma generator from the tank 3 can be controlled by a shutoff valve 15.
  • the article to be sterilized is placed in the sterilization chamber l, the vacuum pump 13 is started to evacuate the chamber; and the shut-off valve 15 is openedto enable gas'to flow
  • the radio-frequency generator 7 is then energized and the impedance matching network 8 is adjusted to minimize reflected power.
  • the article is subjected to the flow over it of the gas plasma passing through the sterilization chamber for the period of time required to effect sterilization. Reductions in microbial population as much as 99% have been accomplished by exposure of the article .to be sterilized to plasma flowfor a period of time as short as five minutes.
  • the radio frequency generator 7 is deenergized, the gas supply valve I5 is closed, and the vacuum pump 13 is stopped or its connection to the sterilization chamber is severed by a suitable valve.
  • the sterilization chamber is then vented to atmosphere, the chamber is opened, and the sterilized object removed from it.
  • the apparatus shown in FIGS. 2, 3 and 4 is of the type particularly adapted to the sterilization of artificial lung blood oxygenators.
  • the apparatus preferably is capable of sterilizing several of such oxygenators at the same time, three of such oxygenators, 2a, 2b and 2c, being shown in FIG. 2.
  • Such oxygenators are housed in the sterilization chamber 1 during the sterilization operation.
  • Thev apparatus shown in FIG. 2 includes components generally similar to those described in connection with the apparatus of FIG. 1. v
  • Gas to be excited into plasma is'supplied from the supplying tank 3 through the flowmeter ,4,-to a' manifold 5' of the plasma generator.- The amount of gas flow is indicated by the flowmeter pressure gauge 12 and the flow to the sterilization chamber'canbe' initiated and terminated by operation of the shutoffvalve 15. Flow of the gas plasma through the sterilization chamber 1' is induced by suction created by the vacuum pump 13. Theconnection between the sterilization chamber and the vacuum pump can be severed by closing valve 16 to avoid the necessity of stopping thevacuum pump between sterilizing operations.
  • An oil trap I'Z may be included in the suction line to pump 13, an'd a venting valve l8 for connecting the sterilization chamber 1' with atmosphere may be provided in the suction line to the vacuum pump.
  • Individual pipes 5'f connect the manifold 5 to the individual oxygenators 2a, 2b and 2c, respectively-A radio frequency field.
  • for converting the gas to plasma is produced by the exciters 6 in each of the gassupply pipes 5".
  • the radio-frequency field is created by such exciters connected'to the radio-frequency generator 7, including an oscillator and an amplifier.
  • the impedance matching network is adjusted by the radiofrequency tuner'8, and the power ,of the radio frequency oscillator is indicated by the wattmeter 9'.
  • the blood oxygenators to be sterilized are shown in oxygenator includes a multiplicity of capillary tubes 22 through which the gas plasma flows slowly to effect the sterilizing action.
  • the resistance to flow of gas plasma through different oxygenators may vary, and the opening of valves 19 can be adjusted to equalize the flow effected through the oxygenators from the common manifold
  • it is only essential that the interiors of the capillary passages through the oxygenator be sterile because only such capillary passages come into contact with blood being oxygenated it is desirable to have a completely sterilized oxygenator packaged in a sealed container to facilitate storage. It is therefore desirable to provide for flow of gas plasma over the exterior of the oxygenator at the same time that gas plasma is flowing through the capillary passages of the oxygenator.
  • FIG. 3 shows an enclosure 23 for the oxygenator having an inlet 24 and an outlet 25 for flow of gas plasma between the enclosure and the exterior of the oxygenator to the interior of the sterilization chamber 1' shown in FIG. 2.
  • Such enclosure is sealed around the inlet 20 and the exit 21 for the gas plasma flowing through the interior of the oxygenator. If the enclosure is in the form of a plastic bag, the openings 20, 21, 24 and 25 can all be sealed to maintain the sterilized condition both of the interior and of the exterior of the oxygenator.
  • the gas plasma flows through the interior of the oxygenator 2' and then over the exterior of the oxygenator sequentially.
  • the plasma exit 21 from the interior of the oxygenator discharges into the interior of the enclosure 23.
  • the gas plasma is then discharged from the interior of such enclosure, after passing over the exterior of the oxygenator, through the exit 25' to the interior of the sterilization chamber 1' shown in FIG. 2.
  • the sterilizing operation is effected in a more efficient and expeditious manner.
  • the sterilizing action of the gas plasma is also rendered more effective and consequently more expeditious by exposing the surfaces tobe sterilized in a low pressure atmosphere, so that the gas plasma is more dense.
  • the gas plasma can be formed from various gases, but preferably is derived from a monatomic inert gas such as argon, helium or xenon.
  • Such a gas may be excited to form gas plasma by utilizing known techniques such as by subjecting it to a radio-frequency field as discussed above, by a technique such as described in the articles Analytical Applications of Electrodelessly Discharged Gases and Research With Electrodelessly Discharged Gases published in the periodical Journal of Chemical Education, Volume 43, Number 5, May. 1966 and Number 6, June, 1966, respectively.
  • the process is particularly advantageous for the sterilization of various kinds of medical and hospital equipment.
  • Another important application of the process is for sterilization of excrement or other waste material which must be stored for a time, such as in an airplane or a spacecraft, before being discarded. Such waste material may be ejected from a spacecraft and should be sterilized before ejection.
  • the container is a plastic bag having an opening
  • the oxygenator has a tube extending through the opening of the plastic bag and communicating with the interior of the oxygenator, and such bag opening and tube are sealable after the flow of nonoxidizing gas plasma through the bag opening and the tube has been terminated.

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
US00207487A 1971-12-13 1971-12-13 Sterilizing and packaging process utilizing gas plasma Expired - Lifetime US3851436A (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
US00207487A US3851436A (en) 1971-12-13 1971-12-13 Sterilizing and packaging process utilizing gas plasma
CA158,654A CA1004823A (en) 1971-12-13 1972-12-12 Sterilizing process utilizing gas plasma
GB5731772A GB1416723A (en) 1971-12-13 1972-12-12 Sterilizing process and apparatus utilizing gas plasma
JP47125102A JPS4865796A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1971-12-13 1972-12-13
DE2260854A DE2260854A1 (de) 1971-12-13 1972-12-13 Verfahren und vorrichtung zur sterilisierung eines gegenstandes mit gas
FR7244406A FR2169814B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1971-12-13 1972-12-13
CA183,541A CA990925A (en) 1971-12-13 1973-10-17 Sterilizing apparatus utilizing gas plasma

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US00207487A US3851436A (en) 1971-12-13 1971-12-13 Sterilizing and packaging process utilizing gas plasma

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US31395472A Continuation-In-Part 1972-12-11 1972-12-11

Publications (1)

Publication Number Publication Date
US3851436A true US3851436A (en) 1974-12-03

Family

ID=22770770

Family Applications (1)

Application Number Title Priority Date Filing Date
US00207487A Expired - Lifetime US3851436A (en) 1971-12-13 1971-12-13 Sterilizing and packaging process utilizing gas plasma

Country Status (6)

Country Link
US (1) US3851436A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS4865796A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1004823A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE2260854A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2169814B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB1416723A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Cited By (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4042325A (en) * 1976-06-21 1977-08-16 Eli Lilly And Company Method of killing microorganisms in the inside of a container utilizing a plasma initiated by a focused laser beam and sustained by an electromagnetic field
US4148606A (en) * 1976-09-24 1979-04-10 Toray Industries, Inc. Sterilization of dialyzer
WO1981002809A1 (en) * 1980-03-25 1981-10-01 Tegal Corp Package and sterilizing process for same
WO1982001996A1 (en) * 1980-12-12 1982-06-24 Corp Tegal Plasma pressure pulse sterilization
EP0207417A1 (en) * 1985-06-21 1987-01-07 JOHNSON & JOHNSON MEDICAL, INC. Hydrogen peroxide plasma sterilization system
US4756882A (en) * 1985-06-21 1988-07-12 Surgikos Inc. Hydrogen peroxide plasma sterilization system
US4801427A (en) * 1987-02-25 1989-01-31 Adir Jacob Process and apparatus for dry sterilization of medical devices and materials
US4818488A (en) * 1987-02-25 1989-04-04 Adir Jacob Process and apparatus for dry sterilization of medical devices and materials
US4909999A (en) * 1987-07-06 1990-03-20 American Sterilizer Company Flow-through vapor phase sterilization system
US4917586A (en) * 1987-02-25 1990-04-17 Adir Jacob Process for dry sterilization of medical devices and materials
US4931261A (en) * 1987-02-25 1990-06-05 Adir Jacob Apparatus for dry sterilization of medical devices and materials
US4943417A (en) * 1987-02-25 1990-07-24 Adir Jacob Apparatus for dry sterilization of medical devices and materials
US4976920A (en) * 1987-07-14 1990-12-11 Adir Jacob Process for dry sterilization of medical devices and materials
US5115166A (en) * 1989-03-08 1992-05-19 Abtox, Inc. Plasma sterilizer and method
US5178829A (en) * 1989-03-08 1993-01-12 Abtox, Inc. Flash sterilization with plasma
US5184046A (en) * 1990-09-28 1993-02-02 Abtox, Inc. Circular waveguide plasma microwave sterilizer apparatus
US5186893A (en) * 1989-03-08 1993-02-16 Abtox, Inc. Plasma cycling sterilizing process
WO1993012821A1 (en) * 1991-12-20 1993-07-08 Advanced Plasma Systems, Inc. Gas plasma container apparatus and method
US5244629A (en) * 1990-08-31 1993-09-14 Caputo Ross A Plasma sterilizing process with pulsed antimicrobial agent pretreatment
US5288460A (en) * 1989-03-08 1994-02-22 Abtox, Inc. Plasma cycling sterilizing process
US5325020A (en) * 1990-09-28 1994-06-28 Abtox, Inc. Circular waveguide plasma microwave sterilizer apparatus
US5376332A (en) * 1991-02-06 1994-12-27 Abtox, Inc. Plasma sterilizing with downstream oxygen addition
US5413760A (en) * 1989-03-08 1995-05-09 Abtox, Inc. Plasma sterilizer and method
US5413759A (en) * 1989-03-08 1995-05-09 Abtox, Inc. Plasma sterilizer and method
US5472664A (en) * 1989-03-08 1995-12-05 Abtox, Inc. Plasma gas mixture for sterilizer and method
US5482684A (en) * 1994-05-03 1996-01-09 Abtox, Inc. Vessel useful for monitoring plasma sterilizing processes
US5593649A (en) * 1989-03-08 1997-01-14 Abtox, Inc. Canister with plasma gas mixture for sterilizer
US5645796A (en) * 1990-08-31 1997-07-08 Abtox, Inc. Process for plasma sterilizing with pulsed antimicrobial agent treatment
US5650693A (en) * 1989-03-08 1997-07-22 Abtox, Inc. Plasma sterilizer apparatus using a non-flammable mixture of hydrogen and oxygen
US5944919A (en) * 1996-03-27 1999-08-31 Ethicon, Inc. Process for blackening surgical needles
US6230472B1 (en) * 1998-02-17 2001-05-15 Reudiger Haaga Gmbh Process and apparatus for sterilizing, filling and sealing containers
JP2003310720A (ja) * 2002-04-23 2003-11-05 Human Meditek Corp Ltd プラズマ滅菌装置
EP1301218A4 (en) * 2000-03-23 2004-03-24 Human Meditek Co Ltd PLASMA DISINFECTION
FR2850280A1 (fr) * 2003-01-28 2004-07-30 C R I T T Materiaux Depots Et Procede de sterilisation d'objets, notamment d'instruments et accessoires medicaux
US20060018788A1 (en) * 2004-07-23 2006-01-26 Monico Gustavo J Method and apparatus for vapor, gas or gas-liquid treatment of surfaces and articles
WO2005023319A3 (en) * 2003-09-11 2006-05-18 Tuttnauer Israel Ltd Ozone plasma medical sterilization
US7090808B2 (en) 2001-07-09 2006-08-15 Pharmaceutical Systems, Inc. Apparatus for testing sterilization methods and materials
US20070207054A1 (en) * 2006-03-03 2007-09-06 Langford Terrence R Sterilizing apparatus and method
US20070212254A1 (en) * 2004-03-19 2007-09-13 Japan Science And Technology Agency Microwave Plasma Sterilizing Method and Device
EP2177234A1 (en) * 2008-10-17 2010-04-21 Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO A method and an apparatus for cleaning and/or sterilization of an object provided in an enclosure
US8568666B2 (en) 2006-03-03 2013-10-29 Langford Ic Systems, Inc. Apparatus and method for reprocessing lumened instruments
CN104661920A (zh) * 2012-09-24 2015-05-27 雀巢产品技术援助有限公司 用于协调无菌灭菌与无菌包装填充速率的方法和系统
US9089880B2 (en) 2006-03-03 2015-07-28 Langford Ic Systems, Inc. Apparatus and method for reprocessing lumened instruments
EP3079732A4 (en) * 2013-12-10 2017-05-24 Nova Plasma Ltd Container, apparatus and method for handling an implant
US10978277B2 (en) 2015-05-11 2021-04-13 Nova Plasma Ltd. Apparatus and method for handling an implant
US11495438B2 (en) 2017-08-16 2022-11-08 Nova Plasma Ltd. Plasma treating an implant

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2473889A1 (fr) * 1980-01-17 1981-07-24 Biophysics Res & Consult Procede de sterilisation au moyen d'un plasma de gaz
JPS6111049A (ja) * 1984-06-27 1986-01-18 日本真空技術株式会社 マイクロ波放電プラズマ殺菌装置
DE3900883A1 (de) * 1989-01-13 1990-07-19 Technics Plasma Gmbh Verfahren zum sterilisieren oder reinigen von gegenstaenden
FR2654000A1 (fr) * 1989-11-07 1991-05-10 Defitech Sa Procede de desinfection d'un echantillon a partir d'un plasma gazeux.
JP2904328B2 (ja) * 1992-11-24 1999-06-14 三菱電機株式会社 微生物繁殖防止装置
AU5865194A (en) * 1993-02-02 1994-08-29 United Kingdom Atomic Energy Authority Gas activation
GB2274947B (en) * 1993-02-02 1996-10-02 Atomic Energy Authority Uk Gas activation
GB2279873B (en) * 1993-07-16 1996-11-13 Stanley Clifford Jennings Autoclave
RU2067003C1 (ru) * 1995-12-15 1996-09-27 Общество с ограниченной ответственностью Научно-производственная фирма "Плайн" Способ обработки поверхностей тел и устройство для его осуществления

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2972349A (en) * 1958-12-24 1961-02-21 Univ Minnesota Capillary oxygenator
US3383163A (en) * 1964-01-24 1968-05-14 Little Inc A Treatment of surfaces
US3516223A (en) * 1966-06-30 1970-06-23 Andersen Prod H W Apparatus for managing and using volatile substances
US3600126A (en) * 1968-02-05 1971-08-17 Emil J Hellund Asepsis process and apparatus
US3705652A (en) * 1969-03-06 1972-12-12 Biotest Serum Institut Gmbh Apparatus for sterile material exchange

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2972349A (en) * 1958-12-24 1961-02-21 Univ Minnesota Capillary oxygenator
US3383163A (en) * 1964-01-24 1968-05-14 Little Inc A Treatment of surfaces
US3516223A (en) * 1966-06-30 1970-06-23 Andersen Prod H W Apparatus for managing and using volatile substances
US3600126A (en) * 1968-02-05 1971-08-17 Emil J Hellund Asepsis process and apparatus
US3705652A (en) * 1969-03-06 1972-12-12 Biotest Serum Institut Gmbh Apparatus for sterile material exchange

Cited By (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4042325A (en) * 1976-06-21 1977-08-16 Eli Lilly And Company Method of killing microorganisms in the inside of a container utilizing a plasma initiated by a focused laser beam and sustained by an electromagnetic field
US4148606A (en) * 1976-09-24 1979-04-10 Toray Industries, Inc. Sterilization of dialyzer
WO1981002809A1 (en) * 1980-03-25 1981-10-01 Tegal Corp Package and sterilizing process for same
US4321232A (en) * 1980-03-25 1982-03-23 Tegal Corporation Package and sterilizing process for same
WO1982001996A1 (en) * 1980-12-12 1982-06-24 Corp Tegal Plasma pressure pulse sterilization
US4348357A (en) * 1980-12-12 1982-09-07 Motorola, Inc. Plasma pressure pulse sterilization
EP0207417A1 (en) * 1985-06-21 1987-01-07 JOHNSON & JOHNSON MEDICAL, INC. Hydrogen peroxide plasma sterilization system
US4643876A (en) * 1985-06-21 1987-02-17 Surgikos, Inc. Hydrogen peroxide plasma sterilization system
US4756882A (en) * 1985-06-21 1988-07-12 Surgikos Inc. Hydrogen peroxide plasma sterilization system
US4917586A (en) * 1987-02-25 1990-04-17 Adir Jacob Process for dry sterilization of medical devices and materials
US4818488A (en) * 1987-02-25 1989-04-04 Adir Jacob Process and apparatus for dry sterilization of medical devices and materials
US4801427A (en) * 1987-02-25 1989-01-31 Adir Jacob Process and apparatus for dry sterilization of medical devices and materials
US4931261A (en) * 1987-02-25 1990-06-05 Adir Jacob Apparatus for dry sterilization of medical devices and materials
US4943417A (en) * 1987-02-25 1990-07-24 Adir Jacob Apparatus for dry sterilization of medical devices and materials
US4909999A (en) * 1987-07-06 1990-03-20 American Sterilizer Company Flow-through vapor phase sterilization system
US4976920A (en) * 1987-07-14 1990-12-11 Adir Jacob Process for dry sterilization of medical devices and materials
US5115166A (en) * 1989-03-08 1992-05-19 Abtox, Inc. Plasma sterilizer and method
US5178829A (en) * 1989-03-08 1993-01-12 Abtox, Inc. Flash sterilization with plasma
US5650693A (en) * 1989-03-08 1997-07-22 Abtox, Inc. Plasma sterilizer apparatus using a non-flammable mixture of hydrogen and oxygen
US5186893A (en) * 1989-03-08 1993-02-16 Abtox, Inc. Plasma cycling sterilizing process
US5413760A (en) * 1989-03-08 1995-05-09 Abtox, Inc. Plasma sterilizer and method
US5593649A (en) * 1989-03-08 1997-01-14 Abtox, Inc. Canister with plasma gas mixture for sterilizer
US5288460A (en) * 1989-03-08 1994-02-22 Abtox, Inc. Plasma cycling sterilizing process
US5472664A (en) * 1989-03-08 1995-12-05 Abtox, Inc. Plasma gas mixture for sterilizer and method
US5413759A (en) * 1989-03-08 1995-05-09 Abtox, Inc. Plasma sterilizer and method
US5645796A (en) * 1990-08-31 1997-07-08 Abtox, Inc. Process for plasma sterilizing with pulsed antimicrobial agent treatment
US6261518B1 (en) 1990-08-31 2001-07-17 Depuy Orthopaedics, Inc. Process and apparatus for plasma sterilizing with pulsed antimicrobial agent treatment
US5413758A (en) * 1990-08-31 1995-05-09 Abtox, Inc. Apparatus for plasma sterilizing with pulsed antimicrobial agent treatment
US5244629A (en) * 1990-08-31 1993-09-14 Caputo Ross A Plasma sterilizing process with pulsed antimicrobial agent pretreatment
US5325020A (en) * 1990-09-28 1994-06-28 Abtox, Inc. Circular waveguide plasma microwave sterilizer apparatus
US5184046A (en) * 1990-09-28 1993-02-02 Abtox, Inc. Circular waveguide plasma microwave sterilizer apparatus
US5376332A (en) * 1991-02-06 1994-12-27 Abtox, Inc. Plasma sterilizing with downstream oxygen addition
WO1993012821A1 (en) * 1991-12-20 1993-07-08 Advanced Plasma Systems, Inc. Gas plasma container apparatus and method
US5482684A (en) * 1994-05-03 1996-01-09 Abtox, Inc. Vessel useful for monitoring plasma sterilizing processes
US5944919A (en) * 1996-03-27 1999-08-31 Ethicon, Inc. Process for blackening surgical needles
US6230472B1 (en) * 1998-02-17 2001-05-15 Reudiger Haaga Gmbh Process and apparatus for sterilizing, filling and sealing containers
EP1301218A4 (en) * 2000-03-23 2004-03-24 Human Meditek Co Ltd PLASMA DISINFECTION
US7090808B2 (en) 2001-07-09 2006-08-15 Pharmaceutical Systems, Inc. Apparatus for testing sterilization methods and materials
JP2003310720A (ja) * 2002-04-23 2003-11-05 Human Meditek Corp Ltd プラズマ滅菌装置
FR2850280A1 (fr) * 2003-01-28 2004-07-30 C R I T T Materiaux Depots Et Procede de sterilisation d'objets, notamment d'instruments et accessoires medicaux
WO2005023319A3 (en) * 2003-09-11 2006-05-18 Tuttnauer Israel Ltd Ozone plasma medical sterilization
US7700039B2 (en) 2004-03-19 2010-04-20 Japan Science And Technology Agency Microwave plasma sterilizing method and device
US20070212254A1 (en) * 2004-03-19 2007-09-13 Japan Science And Technology Agency Microwave Plasma Sterilizing Method and Device
US20060018788A1 (en) * 2004-07-23 2006-01-26 Monico Gustavo J Method and apparatus for vapor, gas or gas-liquid treatment of surfaces and articles
US20070207054A1 (en) * 2006-03-03 2007-09-06 Langford Terrence R Sterilizing apparatus and method
US9089880B2 (en) 2006-03-03 2015-07-28 Langford Ic Systems, Inc. Apparatus and method for reprocessing lumened instruments
US9023277B2 (en) 2006-03-03 2015-05-05 Langford Ic Systems, Inc. Apparatus and method for reprocessing lumened instruments
US8697001B2 (en) 2006-03-03 2014-04-15 Langford Ic Systems, Inc. Apparatus and method for reprocessing lumened instruments
US8568666B2 (en) 2006-03-03 2013-10-29 Langford Ic Systems, Inc. Apparatus and method for reprocessing lumened instruments
US8658090B2 (en) 2006-03-03 2014-02-25 Langford Ic Systems, Inc. Apparatus and method for reprocessing lumened instruments
US8480807B2 (en) 2008-10-17 2013-07-09 Nederlandse Organisatie voor toegepast-natuurwetenschappelijk onderziek TNO Method and an apparatus for cleaning and/or sterilization of an object provided in a sealed enclosure
WO2010044669A1 (en) * 2008-10-17 2010-04-22 Nederlandse Organisatie Voor Toegepast- Natuurwetenschappelijk Onderzoek Tno A method and an apparatus for cleaning and/or sterilization of an object provided in a sealed enclosure
EP2177234A1 (en) * 2008-10-17 2010-04-21 Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO A method and an apparatus for cleaning and/or sterilization of an object provided in an enclosure
CN104661920A (zh) * 2012-09-24 2015-05-27 雀巢产品技术援助有限公司 用于协调无菌灭菌与无菌包装填充速率的方法和系统
CN108100375A (zh) * 2012-09-24 2018-06-01 雀巢产品技术援助有限公司 用于协调无菌灭菌与无菌包装填充速率的方法和系统
EP3079732A4 (en) * 2013-12-10 2017-05-24 Nova Plasma Ltd Container, apparatus and method for handling an implant
US10426588B2 (en) 2013-12-10 2019-10-01 Nova Plasma Ltd. Container, apparatus and method for handling an implant
US11382732B2 (en) 2013-12-10 2022-07-12 Nova Plasma Ltd. Container, apparatus and method for handling an implant
US10978277B2 (en) 2015-05-11 2021-04-13 Nova Plasma Ltd. Apparatus and method for handling an implant
US11955321B2 (en) 2015-05-11 2024-04-09 Nova Plasma Ltd. Method for handling an implant
US11495438B2 (en) 2017-08-16 2022-11-08 Nova Plasma Ltd. Plasma treating an implant

Also Published As

Publication number Publication date
FR2169814A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1973-09-14
GB1416723A (en) 1975-12-03
JPS4865796A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1973-09-10
CA1004823A (en) 1977-02-08
FR2169814B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1978-03-10
DE2260854A1 (de) 1973-06-20

Similar Documents

Publication Publication Date Title
US3851436A (en) Sterilizing and packaging process utilizing gas plasma
US3948601A (en) Sterilizing process and apparatus utilizing gas plasma
RU2157703C2 (ru) Способ плазменной вакуумной стерилизации изделий
US4321232A (en) Package and sterilizing process for same
US6162395A (en) Sterilization of elongate lumens
EP2135625B1 (en) Microwave plasma sterilizing device and method
RU96121017A (ru) Паровая стерилизация с использованием неорганических комплексов перекиси водорода
JPH11501530A (ja) プラズマ殺菌用装置と方法
JPS61293465A (ja) 過酸化水素プラズマ滅菌システム
KR970020122A (ko) 무기 과산화수소 복합체를 사용한 증기 살균법
US6312646B2 (en) Sterilization of elongate lumens
US3598516A (en) Method of sterilizing
US6171450B1 (en) Method for plasma treatment in hollow bodies
CN108853539A (zh) 一种低温等离子体臭氧灭菌器及灭菌方法
JP3783337B2 (ja) 滅菌装置および滅菌方法
CN100408105C (zh) 容器的消毒方法
CN111372615A (zh) 利用低温灭菌装置的灭菌方法
JP2003506276A (ja) プラスチック容器内の物質を滅菌梱包するための方法及び装置
EP0024439B1 (en) Sterilization of artificial organ
JP2011036559A (ja) 殺菌搬入装置
JPH1130565A (ja) 密閉品のリークテスト方法
JPS57165007A (en) Method and apparatus for degassing dissolved gas in liquid
WO2008107385A1 (en) Process and apparatus for sterilizing liquids for medical use
JP2000205499A (ja) 液体供給装置及び液体供給装置におけるパ―ジ方法
KR920700001A (ko) 이소티오시안산 에스테르의 증기발생제, 이소티오시안산 에스테르의 증기를 사용하는 살균방법 및 그 장치