US3598516A - Method of sterilizing - Google Patents
Method of sterilizing Download PDFInfo
- Publication number
- US3598516A US3598516A US860447*A US3598516DA US3598516A US 3598516 A US3598516 A US 3598516A US 3598516D A US3598516D A US 3598516DA US 3598516 A US3598516 A US 3598516A
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- United States
- Prior art keywords
- steam
- chamber
- load
- sterilizing
- temperature
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/20—Gaseous substances, e.g. vapours
- A61L2/206—Ethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/04—Heat
- A61L2/06—Hot gas
- A61L2/07—Steam
Definitions
- the turning on and off of the solenoid valve to modulate the drain line temperature sets up a pulsing flow of steam and steam pressure condition of approximately 25 to 30 in. Hg which helps to purge the load of entrained air thereby heating the load more rapidly.
- a microbiocidal chemical sterilizing gas is admitted to the sterilizing chamber.
- This invention relates to sterilizing methods and, more particularly, to a method of sterilizing with a gaseous agent, requiring moisture for its activity whereby said method also insures rapid heating as well as moisturization of materials to be sterilized, thereby permitting shorter sterilizing times than have heretofore been possible in commercially available equipment.
- the Hickey Pat. 3,035,886 discloses a sterilizing process wherein the air from the chamber is purged with steam at atmospheric pressure and thereafter, ethylene oxide gas is introduced.
- FIG. 1 is a diagrammatic view of the sterilizer chamber and functioning components according to the invention.
- FIG. 2 is a graph showing load temperature, chamber relative humidity and chamber pressure during the course of a typical sterilizing cycle according to the invention.
- FIG. 3 is a diagram which shows the advantage of time saving over a known sterilizing cycle.
- the vacuum line is closed and the sterilizing gas is admitted to the chamber until a suitable gas concentration is achieved.
- the gas admission is then terminated, gas concentration being maintained, however, by adding make up gas to the chamber as required.
- a sterilizing chamber 10 was outfitted with a vacuum pump 12 connected to the drain line 13 in the bottom of the chamber.
- a heat exchanger 14 was provided and steam at, for example, 50 to p.s.i.g. connected as indicated. To heat, steam is fed to the sterilizer chamber through the charging line 5. Steam was admitted to the chamber through the heat exchanger through the metering valve 17 and the solenoid valve 16. The ethylene oxide was admitted through valve 18 and through the heat exchanger 14 to the sterilizer 10. The walls of the sterilizer chamber were preheated by a steam jacket (not shown) to the desired temperature.
- thermostat 23 in the drain line controlled the solenoid valve in the steam line so that the temperature of the drain line remained at approximately F.
- the metering valve 17 was set to give a flow slightly above that required to maintain the desired temperature in the chamber, the proper amount of steam being controlled by solenoid valve 16 actuated by thermostat 23.
- the gas may be flushed from the chamber by filtered air by way of valve 21 and filter 22. All pressures referred to in this specification are absolute pressures unless otherwise stated.
- EXAMPLE I Load the chamber with materials to be sterilized.
- the cycle time required to sterilize materials and bacterial spores Within the chamber was reduced to less than 60 minutes from the 4 to 6 hour cycle common to conventional systems. Furthermore, this improved method is capable of destroying spores encapsulated within salt crystals and embedded in organic materials within 1 or 2 hours as opposed to the inability of conventional systems to sterilize such preparations regardless of time employed within reasonable limits.
- the chamber was loaded with a cardboard carton containing as many cardboard inserts as the carton would hold with sterility predicated upon the sterilization of a number of accepted sterility contols inserted in the load.
- the cardboard carton was 12 x 12 x 22 inches in dimension.
- Thermocouple lead wires were connected to a potentiometer for measuring temperature rise within the cardboard carbon placed in various locations.
- a humidity sensing element for measuring the moisture content of the load was inserted in the cardboard carton.
- Sterility controls consisting of glassine envelopes containing strips of filter paper impregnated with bacterial spores and dried at standard temperatures and pressures and spore-containing ceramic tiles, also packed in glassine envelopes, were placed in select locations inside the cardboard cartons. After placing the prepared and sealed cardboard cartons into the sterilizing chamber and activating the temperature recording potentiometer and humidity detecting equipment, the gas cycle as described above was initiated, using the following steps:
- EXAMPLE III The chamber was loaded with packaged articles representative of those commonly used in a typical hospital load as predicated upon the sterilization of a number of accepted sterility controls inserted in the packaged articles and using the gas cycle as described herein.
- EXAMPLE IV A typical load of hospital packaged articles with sterility predicated upon the sterilization of accepted sterility controls inserted in the packaged articles was placed in the chamber.
- the materials were made up of hospital articles consisting of packaged rubber cathethers, packaged anesthesia equipment and packaged surgical dressings placed in metal trays to simulate a typical hospital load.
- the steps were carried out as in Examples II and III.
- the exposure period used was 40 minutes.
- EXAMPLE V A load of packaged hospital materials typical of materials used in hospitals and predicating sterility upon the sterilization of accepted sterility controls inserted in the packaged articles and using the gas cycle as described in Example II.
- Materials consisted of such articles as packaged plastic boxes, suction catheters, plastic tubes and items of small glassware were used to make up the test load.
- Patent application cycle Cycle variation Results satisfactory Results unsatisfactory EXAMPLE II
- (a) Cycle variation Patent application cycle (a) Chamber vacuum with steam (a) Chamber vacuum with steam injection for 20 minutes (preinjection for minutes. conditioning (b) Gas charge with steam to 8.0 (b) Gas charge with steam to 8.0
- EXAMPLE III Patent application cycle Cycle variation (a) Chamber vacuum with steam (a) Chamber vacuum with no injection for minutes (presteam injection. conditioning).
- Sterility controls were identical to those listed for Example II and were inserted inside the three cardboard cartons in approximately the same areas as those employed in Example II.
- Sterility control The sterility controls were similar to those listed for Example II and were inserted inside the three cardboard cartons in approximately the same areas as those employed in Example H.
- the attached examples show that under these conditions, the material load is heated and moisturized to a condition in which sterility is attained within a period shorter than many of the presently used ethylene oxide cycles.
- FIG. 3 shows the relationship of load temperatures occurring in a gas cycle utilizing the steam preconditioning phase described herein and in a gas cycle where the preconditioning phase is Omitted.
- Line ACD shows a pressure-time curve in a sterilizing cycle where gas is admitted immediately after vacuum is established.
- Line HI is a load temperature curve which occurs under the conditions designated by line ACD.
- Line AKI shows a pressure-time curve in a sterilizing cycle, such as described in the present disclosure; in which steam is introduced for conditioning at point B.
- Line EFG is a temperature-time curve which occurs wherein steam is injected at the beginning of the Nacuum or conditioning cycle in accordance with the method disclosed herein. This line shows that the load being sterilized has reached the desired operating temperature prior to the time the gas is admitted at point K.
- the graph shows that in the cycle disclosed herein the load temperate reaches the desired value throughout in about 10 minutes.
- the load temperature had reached only about 27 C. (80 F.) at the time gas was admitted. This temperature is far below the desired operating temperature.
- rise of load temperature is very slow, particularly when the preconditioning cycle is omitted and the ethylene oxide mixture is introduced into the chamber immediately after the desired initial vacuum is obtained. Since it has been established that the load of materials is, no doubt, moisturized during the preconditioning phase, although the actual concentration of moisture is not intentionally measured or even maintained at a selected level, humidity curves have been omitted from the graph. As indicated in FIG. 3, load temperatures occurring during the disclosed cycle using no conditioning are very slow in rising to the desired operating temperature, 54C. (130 F.). Significant temperature rise occurs only after the chamber has been charged and the exposure period has been initiated. This is in direct contrast to the shown in the curve EFG where load temperatures rise during the steam-vacuum conditioning phase and reach the desired operating temperature before the chamber is charged with gas.
- a method of sterilizing comprising loading a sealed chamber with articles to be sterilized
- a method of sterilizing comprising loading a sealed chamber with articles to be sterilized, applying a vacuum means to said chamber thereby reducing the pressure in the chamber below atmospheric and simultaneously admitting steam to said chamber at a rate that will maintain the temperature of said chamber at a desired temperature, and continuing said simultaneous vacuum application and steam admission for a predetermined period,
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- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
Description
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US86044769A | 1969-01-02 | 1969-01-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
US3598516A true US3598516A (en) | 1971-08-10 |
Family
ID=25333245
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US860447*A Expired - Lifetime US3598516A (en) | 1969-01-02 | 1969-01-02 | Method of sterilizing |
Country Status (1)
Country | Link |
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US (1) | US3598516A (en) |
Cited By (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5090191A (en) * | 1973-12-14 | 1975-07-19 | ||
US3954406A (en) * | 1969-08-25 | 1976-05-04 | American Sterilizer Company | Load preheating and sterilizing method |
US4066399A (en) * | 1972-06-13 | 1978-01-03 | American Sterilizer Company | Method for humidifying a gas sterilizer |
DE2844871A1 (en) * | 1977-10-17 | 1979-04-19 | Electrolux Ab | PROCEDURE AND ARRANGEMENT FOR STERILIZING OBJECTS WITH FORMALDEHYDE |
US4164538A (en) * | 1977-11-11 | 1979-08-14 | American Sterilizer Company | Load conditioning control method for steam sterilization |
US4203947A (en) * | 1977-11-11 | 1980-05-20 | American Sterilizer Company | Load conditioning control apparatus for steam sterilization |
US4203943A (en) * | 1977-11-11 | 1980-05-20 | American Sterilizer Company | Method of biocidal sterilization using cyclic subatmospheric pressure conditioning |
US4239731A (en) * | 1979-11-21 | 1980-12-16 | American Sterilizer Company | Apparatus for biocidal sterilization using cyclic subatmospheric pressure conditioning |
US4241010A (en) * | 1979-02-06 | 1980-12-23 | American Sterilizer Company | Pressure responsive conditioning control gas sterilization |
US4294804A (en) * | 1979-02-06 | 1981-10-13 | American Sterilizer Company | Pressure responsive conditioning control gas sterilization |
US4337223A (en) * | 1981-02-13 | 1982-06-29 | Ben Venue Laboratories, Inc. | Sterilizing apparatus incorporating recirculation of chamber atmosphere |
WO1982003774A1 (en) * | 1981-05-07 | 1982-11-11 | Chemical Co Mdt | Combination steam and unsaturated chemical vapor sterilizer |
US4380530A (en) * | 1981-02-13 | 1983-04-19 | Ben Venue Laboratories, Inc. | Sterilizer with inflatable article holder |
US4395383A (en) * | 1980-09-19 | 1983-07-26 | Vernitron Corporation | Apparatus for controlling temperature below 212 degrees fahrenheit in a sterilizer chamber |
US4410492A (en) * | 1981-02-13 | 1983-10-18 | Ben Venue Laboratories, Inc. | Sterilizing method incorporating recirculation of chamber atmosphere |
US4447394A (en) * | 1977-10-17 | 1984-05-08 | Aktiebolaget Electrolux | Method for sterilization with formalin |
US4457892A (en) * | 1979-02-06 | 1984-07-03 | American Sterilizer Company | Biocidal gas sterilization and gas leakage determination |
US4770851A (en) * | 1984-12-05 | 1988-09-13 | Joslyn Valve Corp. | Methods for sterilization of materials by chemical sterilants |
US4843867A (en) * | 1987-12-30 | 1989-07-04 | American Sterilizer Company | System for monitoring sterilant vapor concentration |
US4898713A (en) * | 1987-03-30 | 1990-02-06 | Societe Nouvelle D'exploitation La Calhene | Process for sterilizing a tight enclosure and installation for performing this process |
WO2007011603A2 (en) * | 2005-07-16 | 2007-01-25 | Western Precooling Systems | Surface pasteurization of bulk agricultural products |
-
1969
- 1969-01-02 US US860447*A patent/US3598516A/en not_active Expired - Lifetime
Cited By (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3954406A (en) * | 1969-08-25 | 1976-05-04 | American Sterilizer Company | Load preheating and sterilizing method |
US4066399A (en) * | 1972-06-13 | 1978-01-03 | American Sterilizer Company | Method for humidifying a gas sterilizer |
JPS5090191A (en) * | 1973-12-14 | 1975-07-19 | ||
US4447394A (en) * | 1977-10-17 | 1984-05-08 | Aktiebolaget Electrolux | Method for sterilization with formalin |
DE2844871A1 (en) * | 1977-10-17 | 1979-04-19 | Electrolux Ab | PROCEDURE AND ARRANGEMENT FOR STERILIZING OBJECTS WITH FORMALDEHYDE |
US4203943A (en) * | 1977-11-11 | 1980-05-20 | American Sterilizer Company | Method of biocidal sterilization using cyclic subatmospheric pressure conditioning |
US4203947A (en) * | 1977-11-11 | 1980-05-20 | American Sterilizer Company | Load conditioning control apparatus for steam sterilization |
US4164538A (en) * | 1977-11-11 | 1979-08-14 | American Sterilizer Company | Load conditioning control method for steam sterilization |
US4241010A (en) * | 1979-02-06 | 1980-12-23 | American Sterilizer Company | Pressure responsive conditioning control gas sterilization |
US4294804A (en) * | 1979-02-06 | 1981-10-13 | American Sterilizer Company | Pressure responsive conditioning control gas sterilization |
US4457892A (en) * | 1979-02-06 | 1984-07-03 | American Sterilizer Company | Biocidal gas sterilization and gas leakage determination |
US4239731A (en) * | 1979-11-21 | 1980-12-16 | American Sterilizer Company | Apparatus for biocidal sterilization using cyclic subatmospheric pressure conditioning |
US4395383A (en) * | 1980-09-19 | 1983-07-26 | Vernitron Corporation | Apparatus for controlling temperature below 212 degrees fahrenheit in a sterilizer chamber |
US4380530A (en) * | 1981-02-13 | 1983-04-19 | Ben Venue Laboratories, Inc. | Sterilizer with inflatable article holder |
US4410492A (en) * | 1981-02-13 | 1983-10-18 | Ben Venue Laboratories, Inc. | Sterilizing method incorporating recirculation of chamber atmosphere |
US4337223A (en) * | 1981-02-13 | 1982-06-29 | Ben Venue Laboratories, Inc. | Sterilizing apparatus incorporating recirculation of chamber atmosphere |
US4447399A (en) * | 1981-05-07 | 1984-05-08 | Mdt Chemical Company | Combination steam and unsaturated chemical vapor sterilizer |
WO1982003774A1 (en) * | 1981-05-07 | 1982-11-11 | Chemical Co Mdt | Combination steam and unsaturated chemical vapor sterilizer |
US4770851A (en) * | 1984-12-05 | 1988-09-13 | Joslyn Valve Corp. | Methods for sterilization of materials by chemical sterilants |
US4898713A (en) * | 1987-03-30 | 1990-02-06 | Societe Nouvelle D'exploitation La Calhene | Process for sterilizing a tight enclosure and installation for performing this process |
US4843867A (en) * | 1987-12-30 | 1989-07-04 | American Sterilizer Company | System for monitoring sterilant vapor concentration |
WO2007011603A2 (en) * | 2005-07-16 | 2007-01-25 | Western Precooling Systems | Surface pasteurization of bulk agricultural products |
US20070148297A1 (en) * | 2005-07-16 | 2007-06-28 | Bell Laurence D | Surface pasteurization of bulk agricultrual products |
WO2007011603A3 (en) * | 2005-07-16 | 2007-11-01 | Western Precooling Systems | Surface pasteurization of bulk agricultural products |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: MORGAN GUARANTY TRUST COMPANY,NEW YORK Free format text: SECURITY INTEREST;ASSIGNOR:AMERICAN STERILIZER COMPANY, A PA CORP.;REEL/FRAME:004765/0752 Effective date: 19870827 Owner name: MORGAN GUARANTY TRUST COMPANY, 23 WALL STREET, NEW Free format text: SECURITY INTEREST;ASSIGNOR:AMERICAN STERILIZER COMPANY, A PA CORP.;REEL/FRAME:004765/0752 Effective date: 19870827 |
|
AS | Assignment |
Owner name: AMERICAN STERILIZER COMPANY, ONE MELLON BANK CENTE Free format text: RELEASED BY SECURED PARTY;ASSIGNOR:MORGAN GUARANTY TRUST COMPANY OF NEW YORK;REEL/FRAME:005581/0543 Effective date: 19910130 |