US3839330A - 2-alkoxy-4,5-azimidobenzamides - Google Patents
2-alkoxy-4,5-azimidobenzamides Download PDFInfo
- Publication number
- US3839330A US3839330A US00117836A US11783671A US3839330A US 3839330 A US3839330 A US 3839330A US 00117836 A US00117836 A US 00117836A US 11783671 A US11783671 A US 11783671A US 3839330 A US3839330 A US 3839330A
- Authority
- US
- United States
- Prior art keywords
- methoxy
- ethyl
- azimidobenzamide
- pyrrolidylmethyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D249/18—Benzotriazoles
Definitions
- azimidobenzamides of this invention are useful in the control of emesis.
- Such azimidobenzamides administeredto mammals in a dosage of 250 p, mg. (as the base) per kilogram of body weight effectuate 100 percent protection against emesis.
- n 1 or 2
- B is alkyl or alkenyl of one to five carbon atoms
- A is a monovalent radical having either of the formulas:
- R is an alkyl group of one to five carbon atoms
- R. and R are hydrogen or 1 or 2 alkyl radicals of one to five carbon atoms or each is linked together through at least three carbon atoms to form with the nitrogen to which they are attached a heterocyclic radical with or without oxygen, sulfur or an additional nitrogen atom.
- the nitrogen atom has attached thereto hydrogen or an alkyl radical of one to five carbon atoms.
- Examples of monovalent radicals when formula (2) comprises a heterocyclic radical are pyrrolidinyl, piperidinyl, imidazolidinyl, piperazino and thiazolidinyl.
- Examples of monovalent radicals of formula (3) are pyrrolidinyl and piperidinyl.
- the pharmaceutically acceptable salts of the bases described herein may be acid addition salts or quaternary ammonium salts.
- acid addition salts are those of the bases and mineral acids, such as hydrochloric acid, hydrobromic acid or phosphoric acid or those of bases and organic acids, such as citric acid, tartaric acid, lactic acid or acetic acid.
- quaternary ammonium salts are those obtained by reacting the bases described herein with aliphatic or aromatic alkylating agents such as methyl chloride, methyl bromide, dimethyl sulfate, or methyl p-toluenesulfonate.
- compositions of this invention are useful as antiemetics, antispasmodics and analgesics.
- the compound of the invention may be the dextro stereo isomer alone, the levo stereo isomer alone or mixtures of both stereo isomers, such as a racemic mixture of both stereo isomers. If an inactive meso form exists, this invention contemplates such meso form with or without either or both the dextro or levo stereo isomers.
- the compounds of this invention are produced by reacting in an acid medium, such as a mineral acid, a nitrite with a 2-alkoxy-4,5-diaminobenzamide having the formula:
- nitrite may be an organic or inorganic nitrite.
- Amyl nitrite is an example of an organic nitrite, while a metallic nitrite, such as an alkali metal nitrite (e.g. sodium or potassium nitrite) is an example of an inorganic nitrite.
- an alkali metal nitrite e.g. sodium or potassium nitrite
- Stage B N-(diethylaminoethyl)-2-methoxy-4-amino- 5-nitrobenzamidev
- 182 g. (0.68 mol) of methyl 2-methoxy-4-acetamino-S-nitrobenzoate and 600 ml. of glycol and then 236 g. (0.68 mol X 3) of diethylaminoethylamine are added.
- the reaction is slightly exothermic (T 31 C.).
- a suspension is obtained which is heated at 55 C. and at the end of 3/4 of an hour, dissolution is complete and U2 hour later the formation of an abundant preprecipitate is observed.
- reaction mixture is maintained for hours at 55 C. All is then soluble in dilute acetic acid.
- 2-methoxy-4-acetamino-5- mixture is then heated to 50 C. and 390 ml. of hydrochloric acid are introduced in portions.
- the reaction is strongly exothermic.
- the temperature reaches 80 to 100 C. It is cooled if necessary.
- azimidobenzamide Into a 2 liter flask equipped with an agitator, a thermometer and a dropping funnel, there are placed 116 g. (0.284 mol) of dihydrochloride of N- (diethylaminoethyl)-2-methoxy-4,5- diaminobenzamide, 568 ml. of water and 28 ml. of concentrated hydrochloric acid. The mixture is heated at about 40-45 C. to dissolve the mixture. It is cooled to C. and 20 g. (0.284 mol) of sodium nitrate in water are poured drop by drop from the dropping funnel. When the addition is completed, agitation is continued for 1 hour and the temperature allowed to rise to 20 C.
- Stage B N-(l-ethyl-2-pyrrolidylmethyl)-2-methoxy- 4-amino-5-nitro benzamide
- 140 g. 0.52 mol
- methyl 2-methoxy-4-acetamino-S-nitro benzoate 500 ml. of glycol
- 201 g. 0.52 mol X 3
- a thick yellow suspension is obtained which is heated to 55C. and maintained at 55 C. for 120 hours. No apparent transformation of the initial precipitate is observed but at the end of the reaction a sample showed complete solubility in dilute acetic acid.
- the organic solution is decanted and the aqueous solution is extracted once with 200 ml. of methylene chloride and once with 100 ml.
- Stage D N-(1-ethyl-2-pyrrolidylmethyl)-2-methoxy- 4,5-azimidobenzamide
- a 2 liter flask equipped with an agitator, a thermometer and a dropping funnel there are introduced 112 g. (0.278 mol) of hydrochloride of N-(l-ethyl-Z- pyrrolidylmethyl)-2-methoxy-4,5-diamino benzamide, 580 ml. of water and 28 ml. of concentrated hydrochlo ric acid.
- the mixture is heated to 40-45 C. to achieve complete dissolution and then cooled to 0 C. 19 G. of sodium nitrite dissolved in 28 ml.
- Example I1 To produce N-(1-ethyl-2-pyrrolidylmethyl)-2- vinyloxy-4,5 azimidobenzamide, Example I1 is followed except that the addition of 146 g. (0.52 mol) of 2- vinyloxy-4-acetamino-S-nitromethyl benzoate is employed instead of the g. of 2-methoxy-4-acetamino- 5-nitromethyl benzoate.
- Example II To produce N-(1-ethyl-2-imidazolidylmethyl)-2- methoxy-4,5-azimidobenzamide, Example II is followed except that the addition of 202 g. (0.52 mol X 3) of l-ethyl-2-aminomethylimidazolidine is employed instead of the 201 g. of 1-ethyl-2-aminomethylpyrrolidine.
- Example II To produce N-(3-ethyl-2-thiazolidylmethyl)-2- methoxy-4,5-azimidobenzamide, Example II is followed except that the addition of 229 g. (0.52 mol X 3) of 3-ethyl-2-aminomethylthiazolidine is employed instead of the 201 g. of 1-ethyl-2-aminomethyl pyrrolidine.
- Stage A is similar to that described in Example I.
- Stage B Dextro N-(1-ethyl-2-pyrrolidylmethyl)-2- methoxy-4-amino-5-nitrobenzamide
- 80 g. (0.3 mol) of methyl 2-methoxy-4-acetamino-5-nitrobenzoate 285 ml. of glycol
- 84 g. (2.2 X 0.3 mol) of dextro 1- ethyl-2-amino-methylpyrrolidine there are introduced 80 g. (0.3 mol) of methyl 2-methoxy-4-acetamino-5-nitrobenzoate, 285 ml. of glycol and 84 g. (2.2 X 0.3 mol) of dextro 1- ethyl-2-amino-methylpyrrolidine.
- a yellow suspension is obtained which is heated at 55 C. and maintained at that temperature for 216 hours.
- Stage B N-(ethyl-propylaminoethyl)-2-methoxy-4- amino-5-nitrobenzamide
- a 2 liter flask equipped with an agitator and a thermometer there are introduced 188 g. (0.7 mol) of methyl 2-methoxy-4-acetamino-5-nitrobenzoate and 700 ml. of glycol, and then 273 g. (0.7 mol X 3) of ethyl-propylethylene diamine are added.
- the suspension obtained is heated at 55 C. and that temperature is maintained for 72 hours.
- the ester dissolves partially at the beginning of the reaction andthe benzamide formed begins to precipitate. At the end of the reaction, there is total solubility.
- Stage D N-(ethyhpropylaminoethyl)-2-methoxy- 4,5-azimidobenzamide
- 106 g. (0.258 mol) of dihydrochloride-of N-(ethylpropylaminoethyl )-2-methoxy-4,5-diaminobenzamide 516 ml. of water and 26 ml. of concentrated hydrochloric acid. It is heated to dissolve the mixture. It is then cooled at C. and 18 g. (0.258 mol) of sodium nitrite dissolved in 20 ml. of water is poured drop by drop from the dropping funnel. When the addition is completed, the mixture is maintained under agitation at 0 C. for 1 hour, and then allowed to return to room temperature.
- N- (piperidinoethyl)-2-methoxy-4,5-azimidobenzamide LD in mg/kg of composition in base state COMPOSITIONS by intraintraperisubcutamouth venously toneally neously N-(diethylaminoethyl) I500 l43-l46 387-400 600-576 -2-methoxy-4,5- (30% azimidobenzamide mortality) N-( l -ethyl-2-pyrl5 17 69 2 l 4-2l6 330-32] rolidylmethyl)-2- methoxy-4,5-azimidobenzamide Dextro-N-( l-ethyl-2- 84-85 248 339 pyrrolidylmethyl)-2- methoxy-4,5-azimidobenzamide Levo-N-(l-ethyl-2- 83-84 207 243 pyrrolidylmethyh- 2-methoxy-4,5- azimidobenzamide and
- the solid residue is recov ered with 300 ml. of boiling ethanol.
- the remaining sodium chloride is filtered with heat.
- the hydrochloride of N-(ethyl-propylaminoethyl)-2-methoxy-4,5- azimidobenzamide crystallizes. It is dried and washed with alcohol. It is a white solid (mp. 155 C.).
- compositions of this invention have the interesting pharmacological property of being anti-cataleptic.
- the cataleptic activity of the product showed the following results: (results measured at the maximum of the effect, such as after 300 to 360 minutes) azimidobenzamide
- the experimental results were clinically confirmed, the products being administered in the form of tablets or ampules of a pharmaceutically acceptable salt.
- compositions of this invention can be administered in the form of a pharmaceutically acceptable salt in coated pills, injectable ampules or aerosols, suppositories, granulated saccharine or sweetened syrup. 7
- n 1 when A is a heterocyclic radical or 2 when A is a non-heterocyclic radical; B is methyl; and A is:
- R is alkyl of one to five carbon atoms
- R and R are ethyl or propyl or pharmaceutically acceptable salts thereof.
- a compound of claim 1 which is a dextro isomer.
- a compound of claim 1 which is iodomethylate of N-(diethylaminoethyl )-2-methoxy-4,5- azimidobenzamide.
- a compound of claim 1 which is N-(1-ethyl-2- imidazolidylmethyl)-2-methoxy-4,5- azimidobenzamide.
- a compound of claim 1 which is N-(3-ethyl-2- thiazolidylmethyl)-2-methoxy-4,5-azimidobenzamide.
- a compound of claim 1 which is N-(4-ethyl-2- morpholinylmethyl)-2-methoxy-4,5- azimidobenzamide.
- a compound of claim 1 which is N-(l-ethyl-2- piperazinylmethyl)-2-methoxy-4,5-azimidobenzamide.
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR118161A FR6787M (fr) | 1967-08-17 | 1967-08-17 | |
FR127131A FR1572168A (fr) | 1967-08-17 | 1967-11-06 | |
BE719048D BE719048A (fr) | 1967-08-17 | 1968-08-05 | |
OA53344A OA03879A (fr) | 1967-08-17 | 1968-08-05 | Procédé de préparation de 2-alcoxy-4,5-azimido benzamides. |
DE1795653A DE1795653C3 (de) | 1967-08-17 | 1968-08-12 | Verfahren zur Herstellung von 2-Methoxy-4,5-azimidobenzamiden |
DE19681795110 DE1795110C (de) | 1967-08-17 | 1968-08-12 | N Substituierte 2 Methoxy 4,5 azimidobenzamide |
CH1221268A CH496007A (fr) | 1967-08-17 | 1968-08-14 | Procédé de préparation des 2-alcoxy-4,5-azimido benzamides |
GB1232836D GB1232836A (fr) | 1967-08-17 | 1968-08-16 | |
US00117836A US3839330A (en) | 1967-08-17 | 1971-02-22 | 2-alkoxy-4,5-azimidobenzamides |
NL727212623A NL151707B (nl) | 1967-08-17 | 1972-09-18 | Werkwijze voor het bereiden van anti-emetisch werkzame farmaceutische preparaten, alsmede van anti-emetisch werkzame verbindingen. |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR118161A FR6787M (fr) | 1967-08-17 | 1967-08-17 | |
FR127131 | 1967-11-06 | ||
US75173768A | 1968-08-12 | 1968-08-12 | |
US00117836A US3839330A (en) | 1967-08-17 | 1971-02-22 | 2-alkoxy-4,5-azimidobenzamides |
Publications (1)
Publication Number | Publication Date |
---|---|
US3839330A true US3839330A (en) | 1974-10-01 |
Family
ID=27444886
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US00117836A Expired - Lifetime US3839330A (en) | 1967-08-17 | 1971-02-22 | 2-alkoxy-4,5-azimidobenzamides |
Country Status (7)
Country | Link |
---|---|
US (1) | US3839330A (fr) |
BE (1) | BE719048A (fr) |
CH (1) | CH496007A (fr) |
DE (1) | DE1795653C3 (fr) |
FR (2) | FR6787M (fr) |
GB (1) | GB1232836A (fr) |
OA (1) | OA03879A (fr) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4039672A (en) * | 1975-01-11 | 1977-08-02 | Societe D'etudes Scientifiques Et Industrielles De L'ile-De-France | N-(1'-allypyrrolidinyl 2'-methyl) 2-methoxy 4,5-azimido benzamide and its pharmaceutically acceptable salts |
FR2440946A2 (fr) * | 1978-01-20 | 1980-06-06 | Ile De France | Nouveaux benzamides heterocycliques substitues, leurs procedes de preparation et leur application comme modificateurs du comportement |
US4255580A (en) * | 1976-08-04 | 1981-03-10 | Siociete D'etudes Scientifiques Et Industrielles De L'ile-De-France | Substituted 2,3-alkylene bis (oxy) benzamides and derivatives |
US4306072A (en) * | 1976-08-04 | 1981-12-15 | Societe D'etudes Scientifiques Et Industrielles De L'ile | Substituted 2,3-alkylene bis (oxy)-4,5 (or 5,6) azimido benzamides and derivatives thereof |
FR2574795A1 (fr) * | 1984-12-18 | 1986-06-20 | Ile De France | Nouveau procede industriel de synthese du n-((1'-allyl 2'-pyrrolidinyl) methyl) 2-methoxy 4,5-azimido benzamide |
US5610265A (en) * | 1996-02-02 | 1997-03-11 | The United States Of America As Represented By The Secretary Of The Air Force | Armomatic polyimides derived from 2-(N-benzoylimino)-4,4-diaminobiphenyl |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2297041A1 (fr) * | 1975-01-11 | 1976-08-06 | Ile De France | N-(1'-allylpyrrolidinyl 2'methyl)2-methoxy 4,5-azimido benzamide, ses derives et ses procedes de preparation |
FR2699533A1 (fr) * | 1992-12-21 | 1994-06-24 | Mouhtaram Mohamed | Dérivés de N-((1,4-dialkyl-6-arylpipérazine-2-yl)méthyl)benzamides. (Isomères cis et trans) Propriétés pharmacologiques et applications. |
-
1967
- 1967-08-17 FR FR118161A patent/FR6787M/fr not_active Expired
- 1967-11-06 FR FR127131A patent/FR1572168A/fr not_active Expired
-
1968
- 1968-08-05 OA OA53344A patent/OA03879A/fr unknown
- 1968-08-05 BE BE719048D patent/BE719048A/xx not_active IP Right Cessation
- 1968-08-12 DE DE1795653A patent/DE1795653C3/de not_active Expired
- 1968-08-14 CH CH1221268A patent/CH496007A/fr not_active IP Right Cessation
- 1968-08-16 GB GB1232836D patent/GB1232836A/en not_active Expired
-
1971
- 1971-02-22 US US00117836A patent/US3839330A/en not_active Expired - Lifetime
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4039672A (en) * | 1975-01-11 | 1977-08-02 | Societe D'etudes Scientifiques Et Industrielles De L'ile-De-France | N-(1'-allypyrrolidinyl 2'-methyl) 2-methoxy 4,5-azimido benzamide and its pharmaceutically acceptable salts |
US4255580A (en) * | 1976-08-04 | 1981-03-10 | Siociete D'etudes Scientifiques Et Industrielles De L'ile-De-France | Substituted 2,3-alkylene bis (oxy) benzamides and derivatives |
US4306072A (en) * | 1976-08-04 | 1981-12-15 | Societe D'etudes Scientifiques Et Industrielles De L'ile | Substituted 2,3-alkylene bis (oxy)-4,5 (or 5,6) azimido benzamides and derivatives thereof |
FR2440946A2 (fr) * | 1978-01-20 | 1980-06-06 | Ile De France | Nouveaux benzamides heterocycliques substitues, leurs procedes de preparation et leur application comme modificateurs du comportement |
US4673686A (en) * | 1978-01-20 | 1987-06-16 | Societe D'etudes Scientifiques Et Industrielle De L'ile De France | New substituted heterocyclic benzamides, methods of preparing them and their application as behavior modifiers |
DK157008B (da) * | 1978-01-20 | 1989-10-30 | Ile De France | Analogifremgangsmaade til fremstilling af n-pyrrolidinyl- eller n-pyrrolidinylmethylsubstituerede benzamider samt mellemprodukter til brug ved fremstillingen |
FR2574795A1 (fr) * | 1984-12-18 | 1986-06-20 | Ile De France | Nouveau procede industriel de synthese du n-((1'-allyl 2'-pyrrolidinyl) methyl) 2-methoxy 4,5-azimido benzamide |
EP0190524A1 (fr) * | 1984-12-18 | 1986-08-13 | Societe D'etudes Scientifiques Et Industrielles De L'ile-De-France | Nouveau procédé industriel de synthèse du N-[(1'-allyl 2'-pyrrolidinyl) méthyl] 2-méthoxy 4,5-azimido benzamide |
US4804765A (en) * | 1984-12-18 | 1989-02-14 | Societe D'etudes Scientifiques Et Industrielles De L'ile-D-France | Process for synthesizing N-[(1'-allyl-2'pyrrolidinyl) methyl]2-methoxy-4,5-azimidobenzamide |
US5610265A (en) * | 1996-02-02 | 1997-03-11 | The United States Of America As Represented By The Secretary Of The Air Force | Armomatic polyimides derived from 2-(N-benzoylimino)-4,4-diaminobiphenyl |
Also Published As
Publication number | Publication date |
---|---|
OA03879A (fr) | 1975-08-14 |
DE1795653B2 (de) | 1974-10-24 |
FR1572168A (fr) | 1969-06-27 |
FR6787M (fr) | 1969-03-17 |
BE719048A (fr) | 1969-02-05 |
DE1795653C3 (de) | 1975-06-05 |
GB1232836A (fr) | 1971-05-19 |
CH496007A (fr) | 1970-09-15 |
DE1795110B2 (de) | 1973-01-18 |
DE1795110A1 (de) | 1972-03-30 |
DE1795653A1 (de) | 1973-02-08 |
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