US3826413A - Device for dispensing fluids - Google Patents

Device for dispensing fluids Download PDF

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Publication number
US3826413A
US3826413A US00272816A US27281672A US3826413A US 3826413 A US3826413 A US 3826413A US 00272816 A US00272816 A US 00272816A US 27281672 A US27281672 A US 27281672A US 3826413 A US3826413 A US 3826413A
Authority
US
United States
Prior art keywords
duct
vane
valve
stem
aerosol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US00272816A
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English (en)
Inventor
W Warren
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Consort Medical PLC
Original Assignee
Bespak Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bespak Industries Ltd filed Critical Bespak Industries Ltd
Application granted granted Critical
Publication of US3826413A publication Critical patent/US3826413A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A61M15/0093—Inhalators mechanically breath-triggered without arming or cocking, e.g. acting directly on the delivery valve
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A61M15/0096—Hindering inhalation before activation of the dispenser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans

Definitions

  • ABSTRACT A device for dispensing fluid from an aerosol container of the kind which meters discrete doses, operable to dispense the dose when suction is applied.
  • the preferred form of the device has a recess to hold the aerosol with the outlet of the aerosol sealingly secured in a cavity, and a resilient element to seal the outlet from the cavity, which opens into an air duct.
  • the resilient element is held against the cavity outlet by a spring-loaded pivoted arm, and a vane on the arm is located in the air duct, so that suction applied at the outlet of the duct will cause the vane to pivot the arm and release the element.
  • the aerosol is operated to meter a dose, which is held partly in the aerosol outlet and partly in the cavity until suction applied at the outlet of the duct causes the cavity to be opened and the dose dispensed into the duct.
  • Apparatus has been devised in which the user must suck at a mouthpiece and then actuate the aerosol, the user not being able to draw any breath until the aerosol is actuated. This is undesirable as many users have difficulty drawing breath even under normal circumstances.
  • valve mechanism may conveniently be designed to operate under the influence of very low forces.
  • the invention provides a device for dispensing fluid from an aerosol container of the kind described comprising a duct having an inlet and an outlet, means to receive the spray head of the aerosol in sealing engagement therewith so that on actuation of the aerosol a discrete dose of fluid is stored at least partially in the spray head, a flow sensor arranged in the duct and a valve connected to the flow sensor such that when the pressure at the outlet of the duct falls below the pressure on the inlet side by a predetermined amount the valve connects the said receiving means to the duct so that the dose of fluid is free to pass into the duct.
  • the dose is stored partly in the spray head and partly in the receiving means.
  • the aerosol may be of the kind in which movement of the aerosol body toward the spray head causes a dose of fluid to be ejected into the spray head.
  • the aerosol may be of the kind in which movement of the aerosol body towards the spray head causes a dose of fluid to be prepared for ejection into the spray head and return movement of the aerosol away from the spray head causes ejection of the dose.
  • the aerosol may be of the kind in which movement of the aerosol body towards the spray head causes continuous flow of fluid into the spray head. To eject a discrete dose with either of these two alternative aerosols it is necessary to move the aerosol body towards the spray head and then away from the spray head.
  • the device may include means to prevent connection of the duct to the receiving means until the discrete dose has been ejected into the spray head.
  • the flow sensor preferably comprises a movable vane mounted in the duct.
  • the valve member may comprise a resilient member urgeable against an aperture in the receiving means which aperture leads to a port in the duct.
  • the vane is pivotally mounted and the valve member is arranged on a lever rigidly mounted on the vane.
  • the valve may be spring urged against the said aperture (e.g., by a spring connected to the vane).
  • means may be provided to urge the valve against the aperture just before fluid is ejected into the spray head, the flow sensor acting to release said means.
  • the device may include means for relieving the seating pressure of the valve when the device is not in use.
  • an inhaling device for dispensing medicament to, for instance, asthma sufferers comprises a plastics casing 11 having an outlet orifice 12 of a suitable size and shape for insertion into the mouth of a user.
  • the casing 11 defines a recess 13 in which there is placed an aerosol-type medicament dispenser 14.
  • the dispenser 14 is of a known type, and incorporates a metering valve 15 having a spray stem 16, which valve operates to eject into the stem 16 a predetermined amount of medicament when the dispenser 14 is pressed downwards while the stem 16 is supported against movement.
  • the stem is received sealingly in socket 18.
  • a control assembly comprising a body 17, vane 31, lever 26 and socket 19.
  • the socket l9 and body 17 are rigidly interconnected and lever 26, which is integral with vane 31, is pivotally mounted in the body 17 by means of a saddle 26a which straddles a flange 26b.
  • Socket 19 receives socket l8 and in the cavity between the two sockets there is arranged a resilient valve disc 22. Socket 19 has an outlet port 21. Valve member 22 is movable towards the socket 18 to seal an outlet 18a in the lower end thereof. An operating rod 23 so dimensioned that air entering by the inlet holes 29 must pass up on one side of the vane, over the top of the vane and down past the sockets 18 and 19 to reach the outlet orifice 12. A spring 30 connects the lever to the casing 11, and biases it in a counter clockwise direction.
  • a dust cap 32 is provided, which may be fitted over the outlet orifice 12, and the dust cap includes a tongue 33 engageable with an extension 34 on the lever 26 to move it downwardly, thus releasing the pressure on the valve member 22 when the device is not in use.
  • the dust cap has a further tongue 32a to close the inlet holes.
  • the asthma sufferer inserts the outlet orifice 12 into his mouth, depresses the dispenser 14, and draws a breath. Depression of the dispenser 14 makes available partly' in the stem 16 and partly in socket 18 a dose of medicament, but because the .valve member 22 is held against the socket 18 by the rod 23, this dose is held back. When the user draws breath,
  • operating rod 23 of the valve assembly is mounted on a lever 35 pivoted to the casing 11 and is biased away from the valve assembly by a spring 36 connected to the lever 35.
  • a trigger arm 37 engageable by a projection 38 connected to the air vane 31 (which is here pivoted on the casing 11).
  • a further lever 39 is mounted on the casing 11 and is biased in a clockwise direction by a spring 41.
  • the air vane 31 is initially in the position shown, blocking the inlet 29.
  • the dispenser 14 is depressed to dispense a dose of medicament and as it is depressed the push rod'42 rotates the lever 39 counter clockwise, so that the outer end of the lever lifts the trigger arm 37 and the lever 35 and thus raises the push rod, moving the valve member upwards .to seal the stem 16 before the dose is actually dispensed.
  • depression of the dispenser 14 makes the dose available, under pressure, inthe stem 16.
  • the partial vacuum within the air duct 28 results in the vane 31 rotating in a counter clockwise direction so that the projection 38 engages the top of the trigger arm and moves it away from the lever 39.
  • a lever 44 is used to operate dispenser 14; at the end of the lever'44 a vertically moving slide 45 is arranged, which is engageable with a projection 46 on the trigger arm 37.
  • An interlock 47 between the vane 31 and the trigger arm 37 allows relative vertical movement of the arm and vane but ensures that counter clockwise rotation of the vane causes the trigger arm to move to the left, away from the slide 45.
  • the operating rod 23, the lever 35, the spring 36 and the trigger arm are arranged in a similar manner to that shown in FIG. 2, except that the fulcrum is positioned between the operating rod and the trigger arm rather than at one end of the lever.
  • the lever 44 is depressed, thus depressing the dispenser 14 to release a dose of medicament and at the same time depressing the trigger arm 37 via the slide 45 and the projection- 46.
  • This causes the lever 35 to rotate in a clockwise direction pushing the operating rod 23 and therefore the valve member 22 upwards to seal the dose dispensed in the stem 16 as in the other embodiments described.
  • the vane 31 is rotated counter clockwise and draws the projection 46 away from the slide 45, and when they disengage the spring 36 causes the valve assembly to dispense the dose available in the stem 16, the operating rod 23 being moved downwards.
  • This arrangement has certain advantages, from a mechanical point of view, as the distances moved by the parts involved are increased, thus allowing greater manufacturing tolerances. Furthermore, the force required to operate the device is reduced by the use of the lever 44.
  • the invention provides a device by which 7 the user can obtain the dose of medicament at the correct point in his drawing in of breath, and this is achieved in an arrangement in which the forces required are very low and the parts are not stressed except over the very short period of use.
  • Previous devices have consisted of an arrangement in which an air vane is linked to the dispenser, it being necessary for the patient to suck at the orifice before, and during, depression of the dispenser. The air vane is held in a closed position until such time as the dispenser is operated, so that the patient obtains no air at all until such time as he operates the dispenser, and clearly this is undesirable for asthma sufferers who are in any case short of breath.
  • the drawing of breath by the patient triggers an arrangement which operates the metering valve directly, utilising the energy stored in a spring to overcome the considerable resistance (about 5 lbs) of the metering device.
  • the present invention utilises a two stage action in-which the fluid is dispensed and stored by hand pressure on the dispenser and is released by an air vane arrangement on drawing breath, which release requires very little pressure.
  • the invention includes a miniature version of the present device operated by a battery.
  • this version there is no obstruction to the flow of air, but the commencement of flow is sensed by a Pirani type of gauge in a bridge circuit (e.g., a hot wire anemometer), and a tiny solenoid is switched to release the dose.
  • a Pirani type of gauge in a bridge circuit (e.g., a hot wire anemometer), and a tiny solenoid is switched to release the dose.
  • An aerosol device comprising a housing in which is located an aerosol container of the type which has a tubular valve stem which is depressable against a spring means and internal valve means which is opened when the valve stem is depressed to deliver a discrete metered dose of fluid through the stem and is closed when the stem is released, said housing having receiving means for said container which makes sealing engagement with said stem of said container, and which resists movement of said stem away from said container, a duct in fluid connection with said receiving means, one end of said duct being open to the atmosphere and the other end thereof being arranged for insertion into the mouth of a user, a second valve means disposed exterior of said tubular valve stem to prevent flow of said metered dose from said stem into said duct after the stem has been depressed, a flow sensor arranged in said duct, and means to release said second valve means to allow said dose to flow into said duct when said flow sensor detects a flow of air in the duct caused by a user inhaling through the duct.
  • a device as claimed in claim 1 in which said receiving means comprises a chamber and wherein said dose may be stored partly in said chamber.
  • a device as claimed in claim 3 including means to urge said second valve means against said aperture just before fluid is ejected into the receiving means, said flow sensor acting to release said means.
  • a device as claimed in claim 1 wherein said aerosol container is movably mounted in said housing and wherein movement of said aerosol container to depress said valve stem renders said second valve means inoperative to connect said stem and said duct.
  • a device as claimed in claim 9 in which said vane is pivotally mounted and said valve means is arranged on a lever rigidly connected to the vane.
  • Av device as claimed in claim 10 in which said vane pivots about a hinge between said lever and the end of said duct arranged for insertion into the mouth of the user, said hinge being adjacent said second valve means.
  • a device for dispensing fluid from anaerosol container of the kind described comprising: an elongate housing having two parallel longitudinal chambers therein each having an end access opening, the two openings being at opposite ends of the housing respectively; one chamber being arranged to receive through the access opening the aerosol container, spray head first, and having a socket in the end of the chamber opposite the access opening to sealingly receive the spray head, there being in the base of the socket an outlet aperture for fluid; a base plate; an elongate vane mounted on the plate so as to be pivotable on the plate, about an axis parallel to the plate, the plate having at least one inlet aperture therein on one side of the vane and being connected or connectible to the housing with the vane extending into the other chamber to define a duct which passes from the said inlet aperture up the said one side of the vane, over the top of the vane, down the other side of the vane and past the said outlet aperture of the socket; a lever integral with the vane and carrying a resilient valve member; and
  • a device as claimed in claim 12 including a dust cap mountable in the housing to close both ends of the duct, the cap having a member arranged to move the lever and vane to the position in which the valve member is released, so that when the device is not in use the pressure on the socket exerted by the valve member is relieved.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Nozzles (AREA)
  • Coating Apparatus (AREA)
  • Measuring Volume Flow (AREA)
  • Loading And Unloading Of Fuel Tanks Or Ships (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
US00272816A 1971-07-19 1972-07-18 Device for dispensing fluids Expired - Lifetime US3826413A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3379371A GB1392192A (en) 1971-07-19 1971-07-19 Devices for dispensing fluids from pressurised dispensing con tainers

Publications (1)

Publication Number Publication Date
US3826413A true US3826413A (en) 1974-07-30

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US00272816A Expired - Lifetime US3826413A (en) 1971-07-19 1972-07-18 Device for dispensing fluids

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US (1) US3826413A (uk)
AR (1) AR193533A1 (uk)
AT (1) AT335047B (uk)
BE (1) BE786421A (uk)
BR (1) BR7204762D0 (uk)
CA (1) CA961458A (uk)
CH (1) CH555681A (uk)
CS (1) CS164928B2 (uk)
DE (1) DE2235247A1 (uk)
DK (1) DK136018B (uk)
EG (1) EG10691A (uk)
ES (1) ES404952A1 (uk)
FR (1) FR2146261B1 (uk)
GB (1) GB1392192A (uk)
HU (1) HU168483B (uk)
IE (1) IE36534B1 (uk)
IL (1) IL39916A (uk)
NL (1) NL7209897A (uk)
NO (2) NO134730C (uk)
PH (1) PH9864A (uk)
PL (1) PL85732B1 (uk)
SE (1) SE383101B (uk)
ZA (1) ZA724383B (uk)

Cited By (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4291688A (en) * 1979-01-11 1981-09-29 Schering Corp. Inhalation device
US4576157A (en) * 1983-10-24 1986-03-18 Raghuprasad Puthalath K Oral inhalation apparatus
DE3816276A1 (de) * 1987-05-12 1988-11-24 Glaxo Inc Inhalationsgeraet
US4803978A (en) * 1985-08-09 1989-02-14 Johnson Iv John J Apparatus for actuating an inhaler
US4852561A (en) * 1988-07-27 1989-08-01 Sperry C R Inhalation device
WO1990013335A1 (en) * 1989-05-08 1990-11-15 Transtech Scientific, Inc. Disposable inhalation activated pulmonary medicine aerosol device
US5027808A (en) * 1990-10-31 1991-07-02 Tenax Corporation Breath-activated inhalation device
US5031610A (en) * 1987-05-12 1991-07-16 Glaxo Inc. Inhalation device
US5060643A (en) * 1990-08-07 1991-10-29 Tenax Corporation Breath-activated inhalation device
US5069204A (en) * 1989-08-23 1991-12-03 Riker Laboratories, Inc. Inhaler
US5119806A (en) * 1987-05-12 1992-06-09 Glaxo Inc. Inhalation device
US5133343A (en) * 1985-08-09 1992-07-28 Johnson Iv John J Apparatus for supporting an inhaler
US5184761A (en) * 1990-09-20 1993-02-09 Bespak Plc Dispensing apparatus
US5224472A (en) * 1990-02-09 1993-07-06 Solange Quenderff Inhalation device
US5297542A (en) * 1989-06-22 1994-03-29 Raymond J. Bacon Aerosol dispensing device
US5347998A (en) * 1990-07-09 1994-09-20 Minnesota Mining And Manufacturing Company Breath actuated inhaler having an electromechanical priming mechanism
US5392768A (en) * 1991-03-05 1995-02-28 Aradigm Method and apparatus for releasing a controlled amount of aerosol medication over a selectable time interval
US5394866A (en) * 1991-03-05 1995-03-07 Aradigm Corporation Automatic aerosol medication delivery system and methods
US5404871A (en) * 1991-03-05 1995-04-11 Aradigm Delivery of aerosol medications for inspiration
US5450336A (en) * 1991-03-05 1995-09-12 Aradigm Corporation Method for correcting the drift offset of a transducer
US5497764A (en) * 1991-03-05 1996-03-12 Aradigm Corporation Medication cassette for an automatic aerosol medication delivery
US5497763A (en) * 1993-05-21 1996-03-12 Aradigm Corporation Disposable package for intrapulmonary delivery of aerosolized formulations
US5509404A (en) * 1994-07-11 1996-04-23 Aradigm Corporation Intrapulmonary drug delivery within therapeutically relevant inspiratory flow/volume values
US5522385A (en) * 1994-09-27 1996-06-04 Aradigm Corporation Dynamic particle size control for aerosolized drug delivery
US5709202A (en) * 1993-05-21 1998-01-20 Aradigm Corporation Intrapulmonary delivery of aerosolized formulations
US5896853A (en) * 1996-04-26 1999-04-27 Bespak Plc Controlled flow inhalers
US6012454A (en) * 1989-04-28 2000-01-11 Minnesota Mining And Manufacturing Company Dry powder inhalation device
US6119688A (en) * 1991-08-26 2000-09-19 3M Innovative Properties Company Powder dispenser
EP1008361A3 (en) * 1998-12-11 2002-01-16 Bespak Plc Inhalation apparatus
US6397837B1 (en) * 1999-07-22 2002-06-04 Martin W. Ferris Inhaler assistive device
US6405727B1 (en) * 1997-05-23 2002-06-18 Pa Knowledge Limited Inhaler mechanism
US6453900B1 (en) 2000-06-09 2002-09-24 Pulmonary Services, Inc. Inhaler device
US6460537B1 (en) * 1998-11-16 2002-10-08 3M Innovative Properties Company Breath-actuated aerosol dispensers
US6475796B1 (en) 1999-05-20 2002-11-05 Scios, Inc. Vascular endothelial growth factor variants
WO2002088317A2 (en) 2001-05-01 2002-11-07 The Regents Of The University Of California Fusion molecules and methods for treatment of immune diseases
US20030101993A1 (en) * 1998-02-23 2003-06-05 Warby Richard John Drug delivery devices
US6595205B2 (en) 1998-03-27 2003-07-22 Astrazeneca Ab Inhalation device
US20040025870A1 (en) * 2000-09-29 2004-02-12 Nigel Harrison Dosing device
US6698422B2 (en) * 2001-03-12 2004-03-02 Birdsong Medical Devices, Inc. Canister inhaler having a spacer and easy to operate lever mechanism and a flexible, elastic mouthpiece
US20040055602A1 (en) * 1998-03-19 2004-03-25 Riebe Michael Thomas Valve for aerosol container
US20040079362A1 (en) * 1998-09-24 2004-04-29 Astrazeneca Ab Inhaler
US6745761B2 (en) 1998-09-24 2004-06-08 Astrazeneca Ab Inhaler
US20040241800A1 (en) * 1999-05-20 2004-12-02 Jue Rodney Alan Vascular endothelial growth factor dimers
US20050016533A1 (en) * 1999-06-30 2005-01-27 Inhale Therapeutic Systems Systems and methods for aerosolizing pharmaceutical formulations
US20050158394A1 (en) * 2000-02-28 2005-07-21 Vectura Limited Delivery of oral drugs
US20050194006A1 (en) * 2004-03-05 2005-09-08 Hoang Quyen C. Metered dose inhaler housing
WO2005087299A1 (en) * 2004-03-10 2005-09-22 Glaxo Group Limited A dispensing device
US20060087614A1 (en) * 2002-08-12 2006-04-27 Shadduck John H Adaptive optic lens system and method of use
US20060171942A1 (en) * 2005-02-02 2006-08-03 Andrew Saxon Modified fusion molecules for treatment of allergic disease
US20060231093A1 (en) * 2002-11-04 2006-10-19 Simon Burge Pressurised inhalers
US20070163576A1 (en) * 2002-03-22 2007-07-19 Bacon Raymond J Can fixture
US20080283553A1 (en) * 2005-09-14 2008-11-20 Glaxo Group Limited Closure for a Dispensing Device
US7600511B2 (en) 2001-11-01 2009-10-13 Novartis Pharma Ag Apparatus and methods for delivery of medicament to a respiratory system
US20110114089A1 (en) * 2008-07-10 2011-05-19 Bang & Olufsen Medicorn A/S Inhaler and a method of operating it
EP2335726A1 (en) 2001-05-01 2011-06-22 The Regents of the University of California Fusion molecules and methods for treatment of immune diseases
US7971588B2 (en) 2000-05-05 2011-07-05 Novartis Ag Methods and systems for operating an aerosol generator
US8074649B2 (en) 2002-07-18 2011-12-13 Aeon Research And Technology, Inc. Endotracheal tube with feature for delivering aerosolized medication
US8336545B2 (en) 2000-05-05 2012-12-25 Novartis Pharma Ag Methods and systems for operating an aerosol generator
US8961992B1 (en) 2014-04-02 2015-02-24 Tunitas Therapeutics, Inc. Epsigam fusion protein
US9108211B2 (en) 2005-05-25 2015-08-18 Nektar Therapeutics Vibration systems and methods
WO2015187918A2 (en) 2014-06-05 2015-12-10 The Regents Of The University Of California Halogenated ether compounds and methods of inducing anesthesia
US9289568B2 (en) 2012-01-23 2016-03-22 Aeon Research And Technology, Inc. Gas delivery venturi
ITUB20154069A1 (it) * 2015-10-14 2017-04-14 Platinum Corp Srl Dosatore per presidi oftalmici multidose senza conservanti ?multi-single?.
CN114087693A (zh) * 2021-11-08 2022-02-25 佛山市南海科日超声电子有限公司 一种液腔排空装置及液腔排空方法
US11331442B2 (en) 2017-10-09 2022-05-17 Pearl Therapeutics, Inc. Drug delivery systems and related methods
EP4032533A1 (en) 2012-07-10 2022-07-27 The Regents of The University of California Methods of inducing anesthesia
USD978327S1 (en) * 2021-05-07 2023-02-14 Iris Call Carlton Inhaler

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE408265B (sv) * 1975-12-12 1979-06-05 Draco Ab Anordning for koldioxiddriven endosaerosol, avsedd for inhalering
GB8319150D0 (en) * 1983-07-15 1983-08-17 Glaxo Group Ltd Aerosol applicator device
GB8328808D0 (en) * 1983-10-28 1983-11-30 Riker Laboratories Inc Inhalation responsive dispensers
FI69962C (fi) * 1983-12-28 1986-09-12 Huhtamaeki Oy Inhalationsanordning
DE4027390C2 (de) * 1990-08-30 1994-11-03 Boehringer Ingelheim Kg Treibgasfreies Inhalationsgerät
GB9217545D0 (en) * 1992-08-18 1992-09-30 Minnesota Mining & Mfg Inhalation device
US6782886B2 (en) 1995-04-05 2004-08-31 Aerogen, Inc. Metering pumps for an aerosolizer
US6427682B1 (en) 1995-04-05 2002-08-06 Aerogen, Inc. Methods and apparatus for aerosolizing a substance
US6205999B1 (en) 1995-04-05 2001-03-27 Aerogen, Inc. Methods and apparatus for storing chemical compounds in a portable inhaler
EE03997B1 (et) 1995-04-14 2003-04-15 Glaxo Wellcome Inc. Albuterooli doseeriv inhalaator
HUP9800641A3 (en) 1995-04-14 2001-04-28 Glaxo Wellcome Inc Res Triangl Metered dose inhaler for beclomethasone dipropionate
TR199701168T1 (xx) 1995-04-14 1998-05-21 Glaxo Wellcome Inc. Flutikazon Propionat i�in �l��lm�� doz inhaleri.
ES2206572T3 (es) 1995-04-14 2004-05-16 Smithkline Beecham Corporation Inhalador de dosis medida para salmeterol.
US6235177B1 (en) 1999-09-09 2001-05-22 Aerogen, Inc. Method for the construction of an aperture plate for dispensing liquid droplets
US6553988B1 (en) 2000-06-09 2003-04-29 Norton Healthcare, Inc. Medicament dispensing device with a multimaterial diaphragm bounding a pneumatic force chamber
US6543443B1 (en) 2000-07-12 2003-04-08 Aerogen, Inc. Methods and devices for nebulizing fluids
US6546927B2 (en) 2001-03-13 2003-04-15 Aerogen, Inc. Methods and apparatus for controlling piezoelectric vibration
US6554201B2 (en) * 2001-05-02 2003-04-29 Aerogen, Inc. Insert molded aerosol generator and methods
US6732944B2 (en) 2001-05-02 2004-05-11 Aerogen, Inc. Base isolated nebulizing device and methods
US20070089735A1 (en) 2001-06-26 2007-04-26 Alan Langford Aerosol actuator
US7677467B2 (en) 2002-01-07 2010-03-16 Novartis Pharma Ag Methods and devices for aerosolizing medicament
CA2472644C (en) 2002-01-07 2013-11-05 Aerogen, Inc. Devices and methods for nebulizing fluids for inhalation
ES2603067T3 (es) 2002-01-15 2017-02-23 Novartis Ag Métodos y sistemas para hacer funcionar un generador de aerosol
AU2003256253A1 (en) 2002-05-20 2003-12-02 Aerogen, Inc. Aerosol for medical treatment and methods
EP1369139A1 (en) 2002-06-03 2003-12-10 3M Innovative Properties Company Dose indicators and dispensing canister-indicator assemblies
US7296567B2 (en) 2002-09-25 2007-11-20 3M Innovative Properties Company Breath actuated aerosol dispensers
US8616195B2 (en) 2003-07-18 2013-12-31 Novartis Ag Nebuliser for the production of aerosolized medication
US7946291B2 (en) 2004-04-20 2011-05-24 Novartis Ag Ventilation systems and methods employing aerosol generators
GB2470403A (en) * 2009-05-21 2010-11-24 Consort Medical Plc Valve assembly with valve stem for use with an aerosol canister

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3187748A (en) * 1963-04-29 1965-06-08 Merck And Company Inc Inhalation-actuated aerosol device
US3456646A (en) * 1967-01-19 1969-07-22 Dart Ind Inc Inhalation-actuated aerosol dispensing device
US3565070A (en) * 1969-02-28 1971-02-23 Riker Laboratories Inc Inhalation actuable aerosol dispenser
US3605738A (en) * 1969-06-20 1971-09-20 Paul J Ciranna Medicinal spray device

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3187748A (en) * 1963-04-29 1965-06-08 Merck And Company Inc Inhalation-actuated aerosol device
US3456646A (en) * 1967-01-19 1969-07-22 Dart Ind Inc Inhalation-actuated aerosol dispensing device
US3565070A (en) * 1969-02-28 1971-02-23 Riker Laboratories Inc Inhalation actuable aerosol dispenser
US3605738A (en) * 1969-06-20 1971-09-20 Paul J Ciranna Medicinal spray device

Cited By (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4291688A (en) * 1979-01-11 1981-09-29 Schering Corp. Inhalation device
US4576157A (en) * 1983-10-24 1986-03-18 Raghuprasad Puthalath K Oral inhalation apparatus
US5133343A (en) * 1985-08-09 1992-07-28 Johnson Iv John J Apparatus for supporting an inhaler
US4803978A (en) * 1985-08-09 1989-02-14 Johnson Iv John J Apparatus for actuating an inhaler
US5031610A (en) * 1987-05-12 1991-07-16 Glaxo Inc. Inhalation device
US5119806A (en) * 1987-05-12 1992-06-09 Glaxo Inc. Inhalation device
AU605295B2 (en) * 1987-05-12 1991-01-10 Sepracor, Inc. Inhalation device
DE3816276A1 (de) * 1987-05-12 1988-11-24 Glaxo Inc Inhalationsgeraet
US4852561A (en) * 1988-07-27 1989-08-01 Sperry C R Inhalation device
US6012454A (en) * 1989-04-28 2000-01-11 Minnesota Mining And Manufacturing Company Dry powder inhalation device
WO1990013335A1 (en) * 1989-05-08 1990-11-15 Transtech Scientific, Inc. Disposable inhalation activated pulmonary medicine aerosol device
US5297542A (en) * 1989-06-22 1994-03-29 Raymond J. Bacon Aerosol dispensing device
US5069204A (en) * 1989-08-23 1991-12-03 Riker Laboratories, Inc. Inhaler
US5224472A (en) * 1990-02-09 1993-07-06 Solange Quenderff Inhalation device
US5347998A (en) * 1990-07-09 1994-09-20 Minnesota Mining And Manufacturing Company Breath actuated inhaler having an electromechanical priming mechanism
US5060643A (en) * 1990-08-07 1991-10-29 Tenax Corporation Breath-activated inhalation device
US5184761A (en) * 1990-09-20 1993-02-09 Bespak Plc Dispensing apparatus
US5027808A (en) * 1990-10-31 1991-07-02 Tenax Corporation Breath-activated inhalation device
US5520166A (en) * 1991-03-05 1996-05-28 Aradigm Corporation Medication cassette for an automatic aerosol medication delivery system
US5743252A (en) * 1991-03-05 1998-04-28 Aradigm Corporation Method for releasing controlled amount of aerosol medication
US5450336A (en) * 1991-03-05 1995-09-12 Aradigm Corporation Method for correcting the drift offset of a transducer
US5497764A (en) * 1991-03-05 1996-03-12 Aradigm Corporation Medication cassette for an automatic aerosol medication delivery
US5392768A (en) * 1991-03-05 1995-02-28 Aradigm Method and apparatus for releasing a controlled amount of aerosol medication over a selectable time interval
US5394866A (en) * 1991-03-05 1995-03-07 Aradigm Corporation Automatic aerosol medication delivery system and methods
US5826570A (en) * 1991-03-05 1998-10-27 Aradigm Corporation Delivery of aerosol medications for inspiration
US5755218A (en) * 1991-03-05 1998-05-26 Aradigm Corporation Method and apparatus for releasing a controlled amount of aerosol medication over a selectable time interval
US5542410A (en) * 1991-03-05 1996-08-06 Aradigm Corporation Delivery of aeerosol medications for inspiration
US5404871A (en) * 1991-03-05 1995-04-11 Aradigm Delivery of aerosol medications for inspiration
US5608647A (en) * 1991-03-05 1997-03-04 Aradigm Corporation Method for releasing controlled amount of aerosol medication
US5622162A (en) * 1991-03-05 1997-04-22 Aradigm Corporation Method and apparatus for releasing a controlled amount of aerosol medication over a selectable time interval
US5655516A (en) * 1991-03-05 1997-08-12 Aradigm Corporation Delivery of aerosol medications for inspiration
US6119688A (en) * 1991-08-26 2000-09-19 3M Innovative Properties Company Powder dispenser
US5709202A (en) * 1993-05-21 1998-01-20 Aradigm Corporation Intrapulmonary delivery of aerosolized formulations
US5718222A (en) * 1993-05-21 1998-02-17 Aradigm Corporation Disposable package for use in aerosolized delivery of drugs
US5544646A (en) * 1993-05-21 1996-08-13 Aradigm Corporation Systems for the intrapulmonary delivery of aerosolized aqueous formulations
US5497763A (en) * 1993-05-21 1996-03-12 Aradigm Corporation Disposable package for intrapulmonary delivery of aerosolized formulations
US5823178A (en) * 1993-05-21 1998-10-20 Aradigm Corporation Disposable package for use in aerosolized delivery of drugs
EP1366778A2 (en) 1993-05-21 2003-12-03 Aradigm Corporation Systems for the intrapulmonary delivery of aerosolized aqueous formulations
US6014969A (en) * 1993-05-21 2000-01-18 Aradigm Corporation Disposable package for use in aerosolized delivery of antibiotics
US5509404A (en) * 1994-07-11 1996-04-23 Aradigm Corporation Intrapulmonary drug delivery within therapeutically relevant inspiratory flow/volume values
EP1310268A2 (en) 1994-07-11 2003-05-14 Aradigm Corporation Intrapulmonary drug delivery within therapeutically relevant inspiratory flow/volume values
US5957124A (en) * 1994-09-27 1999-09-28 Aradigm Corporation Dynamic particle size control for aerosolized drug delivery
US5522385A (en) * 1994-09-27 1996-06-04 Aradigm Corporation Dynamic particle size control for aerosolized drug delivery
US5896853A (en) * 1996-04-26 1999-04-27 Bespak Plc Controlled flow inhalers
US6405727B1 (en) * 1997-05-23 2002-06-18 Pa Knowledge Limited Inhaler mechanism
US20110010939A1 (en) * 1998-02-23 2011-01-20 Richard John Warby Drug Delivery Devices
US20030101993A1 (en) * 1998-02-23 2003-06-05 Warby Richard John Drug delivery devices
US20080098600A1 (en) * 1998-03-19 2008-05-01 Riebe Michael T Valve for Aerosol Container
US20040055602A1 (en) * 1998-03-19 2004-03-25 Riebe Michael Thomas Valve for aerosol container
US6595205B2 (en) 1998-03-27 2003-07-22 Astrazeneca Ab Inhalation device
US6860262B2 (en) * 1998-09-24 2005-03-01 Astrazeneca Ab Inhaler
US20040079362A1 (en) * 1998-09-24 2004-04-29 Astrazeneca Ab Inhaler
US6745761B2 (en) 1998-09-24 2004-06-08 Astrazeneca Ab Inhaler
US6460537B1 (en) * 1998-11-16 2002-10-08 3M Innovative Properties Company Breath-actuated aerosol dispensers
US6354290B1 (en) * 1998-12-11 2002-03-12 Bespak Plc Inhalation apparatus
EP1008361A3 (en) * 1998-12-11 2002-01-16 Bespak Plc Inhalation apparatus
US20030096754A1 (en) * 1999-05-20 2003-05-22 Pollitt N. Stephen Vascular endothelial growth factor variants
US6475796B1 (en) 1999-05-20 2002-11-05 Scios, Inc. Vascular endothelial growth factor variants
US20050119165A1 (en) * 1999-05-20 2005-06-02 Scios, Inc. Vascular endothelial growth factor dimers
US6887848B2 (en) 1999-05-20 2005-05-03 Scios, Inc. Vascular endothelial growth factor variants
US20040241800A1 (en) * 1999-05-20 2004-12-02 Jue Rodney Alan Vascular endothelial growth factor dimers
US20050016533A1 (en) * 1999-06-30 2005-01-27 Inhale Therapeutic Systems Systems and methods for aerosolizing pharmaceutical formulations
US6397837B1 (en) * 1999-07-22 2002-06-04 Martin W. Ferris Inhaler assistive device
US6681763B2 (en) 1999-07-22 2004-01-27 Martin W. Ferris Inhaler assistive device
US20050158394A1 (en) * 2000-02-28 2005-07-21 Vectura Limited Delivery of oral drugs
EP1941868A2 (en) 2000-02-28 2008-07-09 PharmaKodex Limited Improvements in or relating to the delivery of oral drugs
US8336545B2 (en) 2000-05-05 2012-12-25 Novartis Pharma Ag Methods and systems for operating an aerosol generator
US7971588B2 (en) 2000-05-05 2011-07-05 Novartis Ag Methods and systems for operating an aerosol generator
US6453900B1 (en) 2000-06-09 2002-09-24 Pulmonary Services, Inc. Inhaler device
US7093594B2 (en) * 2000-09-29 2006-08-22 Pfizer Limited Dosing device
US20040025870A1 (en) * 2000-09-29 2004-02-12 Nigel Harrison Dosing device
US6698422B2 (en) * 2001-03-12 2004-03-02 Birdsong Medical Devices, Inc. Canister inhaler having a spacer and easy to operate lever mechanism and a flexible, elastic mouthpiece
US8196573B2 (en) 2001-03-20 2012-06-12 Novartis Ag Methods and systems for operating an aerosol generator
EP2335726A1 (en) 2001-05-01 2011-06-22 The Regents of the University of California Fusion molecules and methods for treatment of immune diseases
WO2002088317A2 (en) 2001-05-01 2002-11-07 The Regents Of The University Of California Fusion molecules and methods for treatment of immune diseases
US7600511B2 (en) 2001-11-01 2009-10-13 Novartis Pharma Ag Apparatus and methods for delivery of medicament to a respiratory system
US20070163576A1 (en) * 2002-03-22 2007-07-19 Bacon Raymond J Can fixture
US7814900B2 (en) 2002-03-22 2010-10-19 Clinical Designs Limited Can fixture
US8074649B2 (en) 2002-07-18 2011-12-13 Aeon Research And Technology, Inc. Endotracheal tube with feature for delivering aerosolized medication
US20060087614A1 (en) * 2002-08-12 2006-04-27 Shadduck John H Adaptive optic lens system and method of use
US20060231093A1 (en) * 2002-11-04 2006-10-19 Simon Burge Pressurised inhalers
US20050194006A1 (en) * 2004-03-05 2005-09-08 Hoang Quyen C. Metered dose inhaler housing
WO2005087299A1 (en) * 2004-03-10 2005-09-22 Glaxo Group Limited A dispensing device
US8397714B2 (en) * 2004-03-10 2013-03-19 Glaxo Group Limited Dispensing device
US9327087B2 (en) 2004-03-10 2016-05-03 Glaxo Group Limited Dispensing device
US20080105253A1 (en) * 2004-03-10 2008-05-08 Glaxo Group Limited Dispensing Device
EP3662948A1 (en) * 2004-03-10 2020-06-10 Glaxo Group Limited A dispensing device
US20090136493A1 (en) * 2005-02-02 2009-05-28 Andrew Saxon Modified fusion molecules for treatment of allergic disease
US7488804B2 (en) 2005-02-02 2009-02-10 The Regents Of The University Of California Modified fusion molecules for treatment of allergic disease
US20060171942A1 (en) * 2005-02-02 2006-08-03 Andrew Saxon Modified fusion molecules for treatment of allergic disease
US9108211B2 (en) 2005-05-25 2015-08-18 Nektar Therapeutics Vibration systems and methods
US20080283553A1 (en) * 2005-09-14 2008-11-20 Glaxo Group Limited Closure for a Dispensing Device
US8578932B2 (en) * 2008-07-10 2013-11-12 Bang & Olufsen Medicom A/S Inhaler and a method of operating it
US20110114089A1 (en) * 2008-07-10 2011-05-19 Bang & Olufsen Medicorn A/S Inhaler and a method of operating it
US10052451B2 (en) 2012-01-23 2018-08-21 Aeon Research And Technology, Inc. Gas delivery venturi
US10525228B2 (en) 2012-01-23 2020-01-07 Aeon Research And Technology Modular pulmonary treatment system
US9289568B2 (en) 2012-01-23 2016-03-22 Aeon Research And Technology, Inc. Gas delivery venturi
US9498592B2 (en) 2012-01-23 2016-11-22 Aeon Research And Technology, Inc. Modular pulmonary treatment system
EP4032533A1 (en) 2012-07-10 2022-07-27 The Regents of The University of California Methods of inducing anesthesia
US8961992B1 (en) 2014-04-02 2015-02-24 Tunitas Therapeutics, Inc. Epsigam fusion protein
US9109030B1 (en) 2014-04-02 2015-08-18 Tunitas Therapeutics, Inc. Epsigam fusion protein
WO2015187918A2 (en) 2014-06-05 2015-12-10 The Regents Of The University Of California Halogenated ether compounds and methods of inducing anesthesia
ITUB20154069A1 (it) * 2015-10-14 2017-04-14 Platinum Corp Srl Dosatore per presidi oftalmici multidose senza conservanti ?multi-single?.
US11331442B2 (en) 2017-10-09 2022-05-17 Pearl Therapeutics, Inc. Drug delivery systems and related methods
US11833292B2 (en) 2017-10-09 2023-12-05 Pearl Therapeutics, Inc. Drug delivery systems and related methods
USD978327S1 (en) * 2021-05-07 2023-02-14 Iris Call Carlton Inhaler
CN114087693A (zh) * 2021-11-08 2022-02-25 佛山市南海科日超声电子有限公司 一种液腔排空装置及液腔排空方法
CN114087693B (zh) * 2021-11-08 2022-12-09 佛山市南海科日超声电子有限公司 一种液腔排空装置及液腔排空方法

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BE786421A (fr) 1972-11-16
ES404952A1 (es) 1975-06-16
DE2235247A1 (de) 1973-02-01
AT335047B (de) 1977-02-25
DK136018C (uk) 1978-01-02
HU168483B (uk) 1976-05-28
AR193533A1 (es) 1973-04-30
PL85732B1 (uk) 1976-04-30
AU4469672A (en) 1974-01-24
IE36534L (en) 1973-01-19
NO134730L (uk) 1900-01-01
CA961458A (en) 1975-01-21
GB1392192A (en) 1975-04-30
BR7204762D0 (pt) 1973-07-10
DK136018B (da) 1977-08-01
ATA604272A (de) 1976-06-15
IE36534B1 (en) 1976-11-24
CH555681A (de) 1974-11-15
NO134730B (uk) 1976-08-30
NO134730C (uk) 1976-12-08
PH9864A (en) 1976-05-11
IL39916A (en) 1974-11-29
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EG10691A (en) 1976-04-30
ZA724383B (en) 1974-02-27

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