US3605738A - Medicinal spray device - Google Patents
Medicinal spray device Download PDFInfo
- Publication number
- US3605738A US3605738A US835131A US3605738DA US3605738A US 3605738 A US3605738 A US 3605738A US 835131 A US835131 A US 835131A US 3605738D A US3605738D A US 3605738DA US 3605738 A US3605738 A US 3605738A
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- United States
- Prior art keywords
- valve
- piston
- tube
- suction
- medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000007921 spray Substances 0.000 title abstract description 18
- 239000000443 aerosol Substances 0.000 abstract description 19
- 239000012530 fluid Substances 0.000 abstract description 6
- 230000001939 inductive effect Effects 0.000 abstract description 2
- 239000013589 supplement Substances 0.000 abstract description 2
- 239000003814 drug Substances 0.000 description 6
- 239000000203 mixture Substances 0.000 description 4
- 239000007788 liquid Substances 0.000 description 3
- 229920001971 elastomer Polymers 0.000 description 2
- 206010012373 Depressed level of consciousness Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 230000003190 augmentative effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 239000000806 elastomer Substances 0.000 description 1
- 239000008246 gaseous mixture Substances 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0091—Inhalators mechanically breath-triggered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
Definitions
- a first valve controls flow into the metering chamber and a second valve attached thereto controls ow through the nozzle tube and the ejection or suction tube.
- the tirst valve is manually operated to cause a predetermined quantity of the medicine-aerosol fluid to lill the metering chamber.
- a piston of large area supports the nozzle tube and is operable, in response to suction applied by the patient to the discharge tube, to close the first valve and open the second valve and thereby cause delivery of the medicine-aerosol charge to the patients mouth or nose simultaneously with inhalation.
- the metering chamber may also communicate momentarily with a chamber closed by the piston at its side opposite from the side exposed to suction pressure so as to supplement the force exerted by the patient.
- Spray devices which utilize a pressurized aerosol to deliver a charge of a medicine-aerosol to a patients mouth or nose are known.
- One type utilizes a discharge tube containing a nozzle and a pressure vessel arranged to be pressed toward each other to cause a predetermined quantity of the medicine-aerosol fluid to enter a metering charnber; then, upon release, the charge is ejected.
- a portion of the medicine-aerosol charge may be employed to pressurize one side of a piston simultaneous with the application of suction pressure on the other side thereof, thereby minimizing the effort required by the patient.
- a pressure vessel communicates with a metering chamber which, in turn, communicates with a nozzle tube carried by a piston of large diameter; the nozzle tube being rice mounted in a larger ejection tube to which the piston is exposed, and novel valve means operable by movement of the piston to cause the metering chamber to be charged, then on application of suction to the piston, to open communication between the metering chamber and the nozzle tube.
- FIG. l is an enlarged longitudinal sectional view of the medicinal spray device, with the parts shown in their normal condition', that is, essentially as they appear between uses of the device.
- FIG. 2 is a fragmentary sectional View, taken within circle 2 of FIG. 1.
- FIGS. 3, 4, 5 and 6 are fragmentary sectional views, corresponding to FIG. 2, showing succeeding stages of operation of the medicinal spray device.
- FIG. 7 is a further enlarged sectional view of the valve member.
- FIG. 8 is a further enlarged fragmentary transverse sectional view, taken through 8 8 0f FIG. 1.
- the medicinal spray device includes a pressure vessel 1, having a bottom wall 2 containing an outlet port 3.
- a body member 4 is joined to the pressure vessel 1 by a screwthread connection 5.
- the upper end of the body member 4 seals against the bottom wall 2 of the pressure vessel and is provided with a central cavity which forms a metering chamber 6.
- the lower end of the metering chamber is connected by a passage 7 to a relatively large piston chamber 8.
- a suction tube 9 ⁇ is provided which includes a relatively large vertical portion 10, having an external flange 11, which ts slidably in the piston chamber 8, and is held within the piston chamber 8 by a retainer ring 12.
- the suction tube 9 also includes a horizontal portion 13, dimensioned to be presented to a patients mouth or nose.
- a nozzle tube 14 Centered within the vertical portion 10 of the suction tube is a nozzle tube 14, of small diameter, the lower end of which terminates in a nozzle 15, directed horizontally toward the open end of the horizontal portion 13.
- the upper end of the nozzle tube extends through the passage 7 and into the metering chamber ⁇ 6.
- a piston 16 Formed integrally with the nozzle tube 14 is a piston 16, which fits slidably within the piston chamber 8, and may be provided with a peripheral lip facing toward the closed end of the chamber 8.
- a spring 17 is interposed between the anged end of the suction tube 9 and the piston 16 so as to urge the piston upwardly toward the closed end of the piston chamber 8.
- a valve member 18 formed of rubber or other elastomer is received in the outlet port 3 of the pressure vessel and extends to the nozzle tube 14.
- the valve member includes a ilanged upper end which engages a correspondingly anged upper end of the outlet port 3 so as to form therewith a pressure vessel valve means 19.
- the lower extremity of the valve member is conical and fits a conical recess in the upper end of the nozzle tube 14 to form a nozzle tube valve means 20.
- a spring 21 is fitted around the valve member, as shown in FIGS. 1 and 7 (the spring being omitted from the other figures).
- the lower end of the spring is suitably secured to the -valve member 18 adjacent its lower end and the upper end of the spring bears against the bottom Wall 2.
- the nozzle tube 14 iits loosely within the passage 7, and the passage 7 is provided with a channel which receives a transfer valve ring 22.
- a relatively short axial portion of the nozzle tube is provided with a set of grooves 23; that is, the nozzle tube is essentially triangular in cross section in this region, as shown in FIG. 8.
- the device To initiate ruse of the device, the device is held in the position shown in FIG. l; that is, with the pressure vessel above the suction tube.
- the suction tube is pressed upwardly with respect to the pressure chamber, compressing the spring 17 so as to force the nozzle tube 14 and piston 16 upwardly through the position shown in FIG. 2 to the position shown in FIG. 3.
- This operation cocks the medicinal spray device by permitting a charge of the medicine-aerosol mixture to enter the metering chamber 6.
- the mixture remains in a liquid state or nearly so.
- the suction tube is released, the suction tube returns to the position shown in FIG. 1. However, the nozzle tube and piston remain in the position shown in FIG. 3.
- the piston 16 moves upwardly from the position shown in FIG. 6 toward the position shown in PIG. 1 a suicient distance to close the nozzle tube valve 20 without opening the pressure vessel valve 19. It is not intended that the piston 16 provide an airtight seal with the piston chamber 8, so that any residual pressure existing above the piston 16 and in the metering chamber 6 will be gradually relieved until the pressure therein has returned to atmospheric pressure, at which time the spray device is ready for reuse.
- the medicinal spray device is primarily intended for human use, it should be pointed out that in view of the fact that the medicine is discharged automatically when a suction pressure is applied, the dew'ce is uniquely suited for administering the medicine to animals.
- the medicine need not be in liquid form, but may be a microine powder suspended in the aerosol.
- a spray device for medicine-aerosol fluids comprising:
- (b) means dening a metering chamber, a relatively large piston chamber and passages connecting said pressure vessel and chambers;
- valve member extending from said pressure vessel to said nozzle tube and including a rst valve means operable to close said pressure vessel and a second valve means operable to close said nozzle tube;
- said ejection tube being manually operable to open said first valve means while said second valve means remains closed, thereby to permit a charge of medicine-aerosol fluid to enter said metering chamber, said piston being responsive to suction pressure in said ejection tube to open said second valve means and close said first valve means thereby to cause the medicine-aerosol uid to ow through said nozzle tube and issue from said ejection tube.
- a spray device as defined in claim 1, wherein:
- a momentary operable valve means is interposed between said metering chamber and said piston chamber to permit a portion of said medicine-aerosol fluid to enter said piston chamber and exert a force against one side of said piston augmenting the suction force against the other side of said piston.
Abstract
A DEVICE FOR PRODUCING FROM A PRESSURE VESSEL A PREDETERMINED SPRAY CHARGE CONTAINING AN INHALANT MEDICINE AND A PRESSURIZING AEROSOL, THE VESSEL COMMUNICATING WITH A METERING CHAMBER WHICH, IN TURN, COMMUNICATES WITH A NOZZLE TUBE LOCATED WITHIN AN EJECTION TUBE INTENDED TO BE PLACED IN SUCTION INDUCING RELATION WITH A PATIENT''S MOUTH OR NOSE. A FIRST VALVE CONTROLS FLOW INTO THE METERING CHAMBER AND A SECOND VALVE ATTACHED THERETO CONTROLS FLOW THROUGH THE NOZZLE TUBE AND THE EJECTION OR SUCTION TUBE. THE FIRST VALVE IS MANUALLY OPERATED TO CAUSE A PREDETERMINED QUANTITY OF THE MEDICINE-AEROSOL FLUID TO FILL THE METERING CHAMBER. A PISTON OF LARGE AREA SUPPORTS
THE NOZZLE TUBE AND IS OPERABLE, IN RESPONSE TO SUCTION APPLIED BY THE PATIENT TO THE DISCHARGE TUBE, TO CLOSE THE FIRST VALVE AND OPEN THE SECOND VALVE AND THEREBY CAUSE DELIVERY OF THE MEDICINE-AEROSOL CHARGE TO THE PATIENT''S MOUTH OR NOSE SIMULTANEOUSLY WITH INHALATION. BY MEANS OF A THIRD VALVE, THE METERING CHAMBER MAY ALSO COMMUNICATE MOMENTARILY WITH A CHAMBER CLOSED BY THE PISTON AT ITS SIDE OPPOSITE FROM THE SIDE EXPOSED TO SUCTION PRESSURE SO AS TO SUPPLEMENT THE FORCE EXERTED BY THE PATIENT.
THE NOZZLE TUBE AND IS OPERABLE, IN RESPONSE TO SUCTION APPLIED BY THE PATIENT TO THE DISCHARGE TUBE, TO CLOSE THE FIRST VALVE AND OPEN THE SECOND VALVE AND THEREBY CAUSE DELIVERY OF THE MEDICINE-AEROSOL CHARGE TO THE PATIENT''S MOUTH OR NOSE SIMULTANEOUSLY WITH INHALATION. BY MEANS OF A THIRD VALVE, THE METERING CHAMBER MAY ALSO COMMUNICATE MOMENTARILY WITH A CHAMBER CLOSED BY THE PISTON AT ITS SIDE OPPOSITE FROM THE SIDE EXPOSED TO SUCTION PRESSURE SO AS TO SUPPLEMENT THE FORCE EXERTED BY THE PATIENT.
Description
Sept. 20, 1971 p, 1 C|RANNA 3,605,738
MEDICINAL SPRAY DEVICE Filed June 20, 1969 #frog/VEVS UnitedStates Patent O 3,605,738 MEDICINAL SPRAY DEVICE Paul J. Ciranna, 1556 N. Euclid Ave., Upland, Calif. 91780 Filed June 20, 1969, Ser. No. 835,131 Int. Cl. A61m 7l/08 U.S. Cl. 12S-173 2 Claims ABSTRACT OF THE DISCLOSURE A device for producing from a pressure vessel a predetermined spray charge containing an inhalant medicine and a pressurizing aerosol, the vessel communicating with a metering chamber which, in turn, communicates with a nozzle tube located within an ejection tube intended to be placed in suction inducing relation with a patients mouth or nose. A first valve controls flow into the metering chamber and a second valve attached thereto controls ow through the nozzle tube and the ejection or suction tube. The tirst valve is manually operated to cause a predetermined quantity of the medicine-aerosol fluid to lill the metering chamber. A piston of large area supports the nozzle tube and is operable, in response to suction applied by the patient to the discharge tube, to close the first valve and open the second valve and thereby cause delivery of the medicine-aerosol charge to the patients mouth or nose simultaneously with inhalation. By means of a third valve, the metering chamber may also communicate momentarily with a chamber closed by the piston at its side opposite from the side exposed to suction pressure so as to supplement the force exerted by the patient.
BACKGROUND OF THE INVENTION Spray devices which utilize a pressurized aerosol to deliver a charge of a medicine-aerosol to a patients mouth or nose are known. One type utilizes a discharge tube containing a nozzle and a pressure vessel arranged to be pressed toward each other to cause a predetermined quantity of the medicine-aerosol fluid to enter a metering charnber; then, upon release, the charge is ejected.
Heretofore such devices have required that the patient inhale precisely at the time the charge is ejected; otherwise, the medicine is wasted. If the patient manipulates the device, precise timing is less difcult than if an attendant or nurse administers the medicine, providing, however, if the patient has deficient coordination or is semiconscious, the required timing is usually not accomplished.
SUMMARY OF THE INVENTION The present invention provides a solution to this problem and is summarized in the following objects:
First, to provide a medicinal spray device which is so arranged that after the device is manipulated to transfer a predetermined quantity of medicine-aerosol mixture to a metering chamber, the subsequent act of inhalation, when the device is placed in close proximity to the patients mouth or nose, automatically releases the charge; thus, simultaneous inhalation and ejection of the charge is assured.
Second, to provide a medicinal spray device of the type indicated in the preceding object, wherein a portion of the medicine-aerosol charge may be employed to pressurize one side of a piston simultaneous with the application of suction pressure on the other side thereof, thereby minimizing the effort required by the patient.
Third, to provide a medicinal spray device wherein a pressure vessel communicates with a metering chamber which, in turn, communicates with a nozzle tube carried by a piston of large diameter; the nozzle tube being rice mounted in a larger ejection tube to which the piston is exposed, and novel valve means operable by movement of the piston to cause the metering chamber to be charged, then on application of suction to the piston, to open communication between the metering chamber and the nozzle tube.
DESCRIPTION OF THE DRAWINGS FIG. l is an enlarged longitudinal sectional view of the medicinal spray device, with the parts shown in their normal condition', that is, essentially as they appear between uses of the device.
FIG. 2 is a fragmentary sectional View, taken within circle 2 of FIG. 1.
FIGS. 3, 4, 5 and 6 are fragmentary sectional views, corresponding to FIG. 2, showing succeeding stages of operation of the medicinal spray device.
FIG. 7 is a further enlarged sectional view of the valve member.
FIG. 8 is a further enlarged fragmentary transverse sectional view, taken through 8 8 0f FIG. 1.
SPECIFICATION The medicinal spray device includes a pressure vessel 1, having a bottom wall 2 containing an outlet port 3. A body member 4 is joined to the pressure vessel 1 by a screwthread connection 5.
The upper end of the body member 4 seals against the bottom wall 2 of the pressure vessel and is provided with a central cavity which forms a metering chamber 6. The lower end of the metering chamber is connected by a passage 7 to a relatively large piston chamber 8.
A suction tube 9` is provided which includes a relatively large vertical portion 10, having an external flange 11, which ts slidably in the piston chamber 8, and is held within the piston chamber 8 by a retainer ring 12. The suction tube 9 also includes a horizontal portion 13, dimensioned to be presented to a patients mouth or nose.
Centered within the vertical portion 10 of the suction tube is a nozzle tube 14, of small diameter, the lower end of which terminates in a nozzle 15, directed horizontally toward the open end of the horizontal portion 13. The upper end of the nozzle tube extends through the passage 7 and into the metering chamber `6. Formed integrally with the nozzle tube 14 is a piston 16, which fits slidably within the piston chamber 8, and may be provided with a peripheral lip facing toward the closed end of the chamber 8. A spring 17 is interposed between the anged end of the suction tube 9 and the piston 16 so as to urge the piston upwardly toward the closed end of the piston chamber 8.
A valve member 18 formed of rubber or other elastomer is received in the outlet port 3 of the pressure vessel and extends to the nozzle tube 14. The valve member includes a ilanged upper end which engages a correspondingly anged upper end of the outlet port 3 so as to form therewith a pressure vessel valve means 19. The lower extremity of the valve member is conical and fits a conical recess in the upper end of the nozzle tube 14 to form a nozzle tube valve means 20.
Should increased thrust of the valve member 18 to close the nozzle tube valve means 20 be desired, a spring 21 is fitted around the valve member, as shown in FIGS. 1 and 7 (the spring being omitted from the other figures). The lower end of the spring is suitably secured to the -valve member 18 adjacent its lower end and the upper end of the spring bears against the bottom Wall 2.
The nozzle tube 14 iits loosely within the passage 7, and the passage 7 is provided with a channel which receives a transfer valve ring 22. The inner periphery of which sealingly engages the nozzle tube 14. A relatively short axial portion of the nozzle tube is provided with a set of grooves 23; that is, the nozzle tube is essentially triangular in cross section in this region, as shown in FIG. 8.
Operation of the medicinal spray device is as follows:
To initiate ruse of the device, the device is held in the position shown in FIG. l; that is, with the pressure vessel above the suction tube. The suction tube is pressed upwardly with respect to the pressure chamber, compressing the spring 17 so as to force the nozzle tube 14 and piston 16 upwardly through the position shown in FIG. 2 to the position shown in FIG. 3. This operation cocks the medicinal spray device by permitting a charge of the medicine-aerosol mixture to enter the metering chamber 6. The mixture remains in a liquid state or nearly so. When the suction tube is released, the suction tube returns to the position shown in FIG. 1. However, the nozzle tube and piston remain in the position shown in FIG. 3. If the open end of the horizontal portion 13 of the suction tube 9 is presented to the patients mouth or nostril, and the patient inhales, a slight vacuum pressure is established in the suction tube and in the region underlying the piston 16. It will be noted that the area of the piston is quite large so that a relatively small suction pressure will tend to move the piston downwardly from the position shown in FIG. 3 through the positions shown in FIGS. 4 and S to the position shown in FIG. 6. This movement takes place relatively rapidly, but in the course of this movement, there is momentary communication between the metering chamber 6 and the upper side of the piston so that a portion of the liquid medicine-aerosol mixture Within the metering chamber will expand as a gas in the region above the piston 16, and the force exerted yby the expanded gaseous mixture augments the suction force applied by the patient, thus reducing the effort required by the patient. When the piston 16 reaches the position shown in FIG. 6, the nozzle tube valve 2.0 opens so that the charge of medicine-aerosol is ejected from the nozzle 1S and into the patients nostril or mouth.
After this operation is completed, the piston 16 moves upwardly from the position shown in FIG. 6 toward the position shown in PIG. 1 a suicient distance to close the nozzle tube valve 20 without opening the pressure vessel valve 19. It is not intended that the piston 16 provide an airtight seal with the piston chamber 8, so that any residual pressure existing above the piston 16 and in the metering chamber 6 will be gradually relieved until the pressure therein has returned to atmospheric pressure, at which time the spray device is ready for reuse.
While the medicinal spray device is primarily intended for human use, it should be pointed out that in view of the fact that the medicine is discharged automatically when a suction pressure is applied, the dew'ce is uniquely suited for administering the medicine to animals.
It should be noted that the medicine need not be in liquid form, but may be a microine powder suspended in the aerosol.
While a particular embodiment of this invention has been shown and described, it is not intended to limit the same to the details of the construction set forth, but instead, the invention embraces such changes, modications and equivalents of the various parts and their relationships as come within the purview of the appended claims.
I claim:
1. A spray device for medicine-aerosol fluids comprising:
(a) a pressure vessel;
(b) means dening a metering chamber, a relatively large piston chamber and passages connecting said pressure vessel and chambers;
(c) a nozzle tube extending from said metering chamber through said piston chamber and including a piston tting said piston chamber;
(d) an ejection tube surrounding said nozzle tube and having an end slidably received in said piston chamber;
(e) a valve member extending from said pressure vessel to said nozzle tube and including a rst valve means operable to close said pressure vessel and a second valve means operable to close said nozzle tube;
(f) said ejection tube being manually operable to open said first valve means while said second valve means remains closed, thereby to permit a charge of medicine-aerosol fluid to enter said metering chamber, said piston being responsive to suction pressure in said ejection tube to open said second valve means and close said first valve means thereby to cause the medicine-aerosol uid to ow through said nozzle tube and issue from said ejection tube.
2. A spray device, as defined in claim 1, wherein:
(a) a momentary operable valve means is interposed between said metering chamber and said piston chamber to permit a portion of said medicine-aerosol fluid to enter said piston chamber and exert a force against one side of said piston augmenting the suction force against the other side of said piston.
References Cited UNITED STATES PATENTS 2,992,645 7/1961 'Fowler 12S-208 3,456,644 '7/l969 Thiel 128-l73 RICHARD A. GAUDET, Primary Examiner G. F. DUNNE, Assistant Examiner U.S. Cl. XR.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US83513169A | 1969-06-20 | 1969-06-20 |
Publications (1)
Publication Number | Publication Date |
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US3605738A true US3605738A (en) | 1971-09-20 |
Family
ID=25268664
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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US835131A Expired - Lifetime US3605738A (en) | 1969-06-20 | 1969-06-20 | Medicinal spray device |
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US (1) | US3605738A (en) |
Cited By (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3698390A (en) * | 1969-10-27 | 1972-10-17 | Frank Donald Ferris | Dispensing for medicaments |
US3826413A (en) * | 1971-07-19 | 1974-07-30 | Bespak Industries Ltd | Device for dispensing fluids |
US4114615A (en) * | 1975-12-12 | 1978-09-19 | Aktiebolaget Draco | Aerosol inhalation device |
US4506803A (en) * | 1982-08-09 | 1985-03-26 | Hoffmann-La Roche Inc. | Metered aerosol dispenser and method of using the dispenser |
US4576157A (en) * | 1983-10-24 | 1986-03-18 | Raghuprasad Puthalath K | Oral inhalation apparatus |
US4664107A (en) * | 1983-10-28 | 1987-05-12 | Minnesota Mining And Manufacturing Company | Inhalation activatable dispensers |
US4955371A (en) * | 1989-05-08 | 1990-09-11 | Transtech Scientific, Inc. | Disposable inhalation activated, aerosol device for pulmonary medicine |
FR2648793A1 (en) * | 1989-06-22 | 1990-12-28 | Bacon Raymond | AEROSOL DISPENSING DEVICE |
US5069204A (en) * | 1989-08-23 | 1991-12-03 | Riker Laboratories, Inc. | Inhaler |
WO1992009323A1 (en) * | 1990-12-01 | 1992-06-11 | Norton Healthcare Limited | Medicament dispensing device |
EP0490797A1 (en) * | 1990-12-13 | 1992-06-17 | Tenax Corporation | Inhalation actuated dispensing apparatus |
US5184761A (en) * | 1990-09-20 | 1993-02-09 | Bespak Plc | Dispensing apparatus |
US5224472A (en) * | 1990-02-09 | 1993-07-06 | Solange Quenderff | Inhalation device |
US5297542A (en) * | 1989-06-22 | 1994-03-29 | Raymond J. Bacon | Aerosol dispensing device |
WO1994011044A2 (en) | 1992-11-12 | 1994-05-26 | Minnesota Mining And Manufacturing Company | Powder inhaler |
US5347998A (en) * | 1990-07-09 | 1994-09-20 | Minnesota Mining And Manufacturing Company | Breath actuated inhaler having an electromechanical priming mechanism |
US5402943A (en) * | 1990-12-04 | 1995-04-04 | Dmw (Technology) Limited | Method of atomizing including inducing a secondary flow |
US5405084A (en) * | 1990-12-04 | 1995-04-11 | Dmw (Technology) Limited | Nozzle assembly for preventing back-flow |
US5497944A (en) * | 1990-03-21 | 1996-03-12 | Dmw (Technology) Limited | Atomising devices and methods |
US5511540A (en) * | 1992-08-18 | 1996-04-30 | Minnesota Mining And Manufacturing Company | Inhalation device |
US5632421A (en) * | 1994-07-14 | 1997-05-27 | Rexam Dispenser S.P.A. | Aerosol metering valves |
US5651477A (en) * | 1994-04-01 | 1997-07-29 | Nippon Tansan Gas Company Limited | Constant quantity injection valve for liquefied carbon dioxide gas |
US5964416A (en) * | 1995-10-04 | 1999-10-12 | Boehringer Ingelheim Gmbh | Device for producing high pressure in a fluid in miniature |
US6029661A (en) * | 1991-08-26 | 2000-02-29 | 3M Innovative Properties Company | Powder dispenser |
US6083430A (en) * | 1994-10-28 | 2000-07-04 | Fuisz Technologies Ltd. | Method of preparing a dosage unit by direct tableting and product therefrom |
WO2002068030A2 (en) * | 2001-02-26 | 2002-09-06 | Optinose As | Nasal devices |
US20030079743A1 (en) * | 2001-10-30 | 2003-05-01 | Genova Perry A. | Breath actuated dry powder inhaler |
US20040025867A1 (en) * | 2000-06-09 | 2004-02-12 | Michael Holroyd | Medicament dispensing device with a multimaterial diaphragm bounding a pneumatic force chamber |
US20050173451A1 (en) * | 2002-05-16 | 2005-08-11 | Bioactis Limited | Gas injection valve |
US20050209558A1 (en) * | 2002-06-03 | 2005-09-22 | Eduard Marx | Dose indicators and dispensing canister-indicator assemblies |
US20060118107A1 (en) * | 2002-10-30 | 2006-06-08 | King Michael L | Tubular nozzles for use in systems for delivering medicaments |
US20070175469A1 (en) * | 2005-12-02 | 2007-08-02 | Boehringer Ingelheim International Gmbh, | Dispensing device |
WO2007093784A1 (en) * | 2006-02-14 | 2007-08-23 | Optinose As | Delivery device and method |
US7814900B2 (en) | 2002-03-22 | 2010-10-19 | Clinical Designs Limited | Can fixture |
EP3124067A3 (en) * | 1999-03-03 | 2017-05-24 | Optinose AS | Nasal delivery device |
WO2022261552A1 (en) * | 2021-06-11 | 2022-12-15 | Boa Nutrition, Inc. | Nozzle with fan for delivering aerosols |
-
1969
- 1969-06-20 US US835131A patent/US3605738A/en not_active Expired - Lifetime
Cited By (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3698390A (en) * | 1969-10-27 | 1972-10-17 | Frank Donald Ferris | Dispensing for medicaments |
US3826413A (en) * | 1971-07-19 | 1974-07-30 | Bespak Industries Ltd | Device for dispensing fluids |
US4114615A (en) * | 1975-12-12 | 1978-09-19 | Aktiebolaget Draco | Aerosol inhalation device |
US4506803A (en) * | 1982-08-09 | 1985-03-26 | Hoffmann-La Roche Inc. | Metered aerosol dispenser and method of using the dispenser |
US4576157A (en) * | 1983-10-24 | 1986-03-18 | Raghuprasad Puthalath K | Oral inhalation apparatus |
US4664107A (en) * | 1983-10-28 | 1987-05-12 | Minnesota Mining And Manufacturing Company | Inhalation activatable dispensers |
US4955371A (en) * | 1989-05-08 | 1990-09-11 | Transtech Scientific, Inc. | Disposable inhalation activated, aerosol device for pulmonary medicine |
BE1004005A4 (en) * | 1989-06-22 | 1992-09-08 | Glaxo Group Ltd | Distributor device aerosol. |
FR2648793A1 (en) * | 1989-06-22 | 1990-12-28 | Bacon Raymond | AEROSOL DISPENSING DEVICE |
GR900100474A (en) * | 1989-06-22 | 1991-11-15 | Bacon Raymond J | Aerosole sprayer |
US5297542A (en) * | 1989-06-22 | 1994-03-29 | Raymond J. Bacon | Aerosol dispensing device |
US5069204A (en) * | 1989-08-23 | 1991-12-03 | Riker Laboratories, Inc. | Inhaler |
US5224472A (en) * | 1990-02-09 | 1993-07-06 | Solange Quenderff | Inhalation device |
US5497944A (en) * | 1990-03-21 | 1996-03-12 | Dmw (Technology) Limited | Atomising devices and methods |
US5662271A (en) * | 1990-03-21 | 1997-09-02 | Boehringer Ingelheim International Gmbh | Atomizing devices and methods |
US5347998A (en) * | 1990-07-09 | 1994-09-20 | Minnesota Mining And Manufacturing Company | Breath actuated inhaler having an electromechanical priming mechanism |
US5184761A (en) * | 1990-09-20 | 1993-02-09 | Bespak Plc | Dispensing apparatus |
AU644925B2 (en) * | 1990-12-01 | 1993-12-23 | Norton Healthcare Limited | Medicament dispensing device |
AP320A (en) * | 1990-12-01 | 1994-03-01 | Norton Healthcare Ltd | Medicament dispensing device. |
CN1306971C (en) * | 1990-12-01 | 2007-03-28 | 诺顿·希尔思凯尔有限公司 | Medicament dispensing device |
US5447150A (en) * | 1990-12-01 | 1995-09-05 | Norton Healthcare Limited | Medicament dispensing device |
WO1992009323A1 (en) * | 1990-12-01 | 1992-06-11 | Norton Healthcare Limited | Medicament dispensing device |
US5402943A (en) * | 1990-12-04 | 1995-04-04 | Dmw (Technology) Limited | Method of atomizing including inducing a secondary flow |
US5405084A (en) * | 1990-12-04 | 1995-04-11 | Dmw (Technology) Limited | Nozzle assembly for preventing back-flow |
US5217004A (en) * | 1990-12-13 | 1993-06-08 | Tenax Corporation | Inhalation actuated dispensing apparatus |
AU653562B2 (en) * | 1990-12-13 | 1994-10-06 | Tenax Corporation | Inhalation actuated dispensing apparatus |
EP0490797A1 (en) * | 1990-12-13 | 1992-06-17 | Tenax Corporation | Inhalation actuated dispensing apparatus |
US6119688A (en) * | 1991-08-26 | 2000-09-19 | 3M Innovative Properties Company | Powder dispenser |
US6029661A (en) * | 1991-08-26 | 2000-02-29 | 3M Innovative Properties Company | Powder dispenser |
US5511540A (en) * | 1992-08-18 | 1996-04-30 | Minnesota Mining And Manufacturing Company | Inhalation device |
WO1994011044A2 (en) | 1992-11-12 | 1994-05-26 | Minnesota Mining And Manufacturing Company | Powder inhaler |
US5651477A (en) * | 1994-04-01 | 1997-07-29 | Nippon Tansan Gas Company Limited | Constant quantity injection valve for liquefied carbon dioxide gas |
US5632421A (en) * | 1994-07-14 | 1997-05-27 | Rexam Dispenser S.P.A. | Aerosol metering valves |
US6083430A (en) * | 1994-10-28 | 2000-07-04 | Fuisz Technologies Ltd. | Method of preparing a dosage unit by direct tableting and product therefrom |
US7104470B2 (en) | 1995-10-04 | 2006-09-12 | Boehringer Ingelheim International Gmbh | Device for producing high pressure in a fluid in miniature |
US6402055B1 (en) | 1995-10-04 | 2002-06-11 | Boehringer Ingelheim Gmbh | Device for producing high pressure in a fluid in miniature |
US6497373B2 (en) | 1995-10-04 | 2002-12-24 | Boehringer International Gmbh | Device for producing high pressure in a fluid in miniature |
US5964416A (en) * | 1995-10-04 | 1999-10-12 | Boehringer Ingelheim Gmbh | Device for producing high pressure in a fluid in miniature |
US20040178227A1 (en) * | 1995-10-04 | 2004-09-16 | Boehringer International Gmbh | Device for producing high pressure in a fluid in miniature |
US6918547B2 (en) | 1995-10-04 | 2005-07-19 | Joachim Jaeger | Device for producing high pressure in a fluid in miniature |
US20050252990A1 (en) * | 1995-10-04 | 2005-11-17 | Joachim Jaeger | Device for producing high pressure in a fluid in miniature |
EP3124067A3 (en) * | 1999-03-03 | 2017-05-24 | Optinose AS | Nasal delivery device |
US20100065050A1 (en) * | 2000-06-09 | 2010-03-18 | Norton Healthcare Limited | Medicament dispensing device with a multimaterial diaphragm bounding a pneumatic force chamber |
US7637260B2 (en) | 2000-06-09 | 2009-12-29 | Norton Healthcare Limited | Medicament dispensing device with a multimaterial diaphragm bounding a pneumatic force chamber |
US20040025867A1 (en) * | 2000-06-09 | 2004-02-12 | Michael Holroyd | Medicament dispensing device with a multimaterial diaphragm bounding a pneumatic force chamber |
US8225780B2 (en) | 2000-06-09 | 2012-07-24 | Norton Healthcare Limited | Medicament dispensing device with a multimaterial diaphragm bounding a pneumatic force chamber |
US20040112378A1 (en) * | 2001-01-26 | 2004-06-17 | Djupesland Per Gisle | Nasal devices |
JP2004528073A (en) * | 2001-02-26 | 2004-09-16 | オプティノーズ アズ | Nasal device |
US7740014B2 (en) | 2001-02-26 | 2010-06-22 | Optinose As | Nasal devices |
US8522778B2 (en) | 2001-02-26 | 2013-09-03 | Optinose As | Nasal devices |
WO2002068030A2 (en) * | 2001-02-26 | 2002-09-06 | Optinose As | Nasal devices |
US20110088691A1 (en) * | 2001-02-26 | 2011-04-21 | Per Gisle Djupesland | Nasal Devices |
WO2002068030A3 (en) * | 2001-02-26 | 2003-02-06 | Optinose As | Nasal devices |
US6779520B2 (en) * | 2001-10-30 | 2004-08-24 | Iep Pharmaceutical Devices Inc. | Breath actuated dry powder inhaler |
US20030079743A1 (en) * | 2001-10-30 | 2003-05-01 | Genova Perry A. | Breath actuated dry powder inhaler |
US7814900B2 (en) | 2002-03-22 | 2010-10-19 | Clinical Designs Limited | Can fixture |
US20050173451A1 (en) * | 2002-05-16 | 2005-08-11 | Bioactis Limited | Gas injection valve |
US20050209558A1 (en) * | 2002-06-03 | 2005-09-22 | Eduard Marx | Dose indicators and dispensing canister-indicator assemblies |
US7464708B2 (en) | 2002-06-03 | 2008-12-16 | 3M Innovative Properties Company | Dose indicators and dispensing canister-indicator assemblies |
US20060118107A1 (en) * | 2002-10-30 | 2006-06-08 | King Michael L | Tubular nozzles for use in systems for delivering medicaments |
US20070175469A1 (en) * | 2005-12-02 | 2007-08-02 | Boehringer Ingelheim International Gmbh, | Dispensing device |
US20100051022A1 (en) * | 2006-02-14 | 2010-03-04 | Optinose As | Delivery device and method |
US8171929B2 (en) | 2006-02-14 | 2012-05-08 | Optinose As | Delivery device and method |
WO2007093784A1 (en) * | 2006-02-14 | 2007-08-23 | Optinose As | Delivery device and method |
WO2022261552A1 (en) * | 2021-06-11 | 2022-12-15 | Boa Nutrition, Inc. | Nozzle with fan for delivering aerosols |
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