US3814297A - Inhalation actuated aerosol device for dispensing a metered quantity of fluid - Google Patents

Inhalation actuated aerosol device for dispensing a metered quantity of fluid Download PDF

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Publication number
US3814297A
US3814297A US00306950A US30695072A US3814297A US 3814297 A US3814297 A US 3814297A US 00306950 A US00306950 A US 00306950A US 30695072 A US30695072 A US 30695072A US 3814297 A US3814297 A US 3814297A
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United States
Prior art keywords
stem
strut
duct
head
aerosol
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Expired - Lifetime
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US00306950A
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English (en)
Inventor
W Warren
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Consort Medical Ltd
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Bespak Industries Ltd
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Publication date
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans

Definitions

  • ABSTRACT A device for dispensing fluid from an aerosol c0ntainer of the kind having a spray stem or spray head which, when actuated, dispenses fluid from the container, the device comprising a duct having an inlet and an outlet, means to receive the aerosol container with the outlet of the spray stem or head communicating with the duct, a strut engageable with the stem or head'so that relative movement of the strut towards the container will press the stem or head inwardly of the aerosol container, and means for disengaging the strut to release the stem or head when the air pressure at the outlet of the duct falls below the air pressure at the inlet of the duct.
  • the invention relates to aerosol containers, and more particularly to devices for dispensing fluid from aerosol containers of the kind having a spray stem or spray head which, when actuated, dispenses fluid from the container.
  • aerosol containers will be referred to hereinafter as aerosol containers of the kind described.
  • Apparatus has been devised in which the user must suck at a mouthpiece and then actuate the aerosol, the user not being able to draw any breath until the aerosol is actuated. This is undesirable as many users have difficulty drawing breath even under normal circumstances.
  • the invention provides a device for dispensing fluid from an aerosol container of the kind described, the device comprising a duct having an inlet and an outlet, means to receive the aerosol container with the outlet of the spray stem or head communicating with the duct, a strut engageable with the stem or head and manually operable to press the stem or head inwardly of the aerosol container, and means for disengaging the strut to release the stem or head when the air pressure at the outlet of the duct falls below the air pressure at the inlet of the duct.
  • the device according to the invention is very suitable for use with an aerosol container containing medicament for asthma sufferers. If the user manually moves the container and the strut toward one another and then sucks at the duct outlet he will receive medicament at or immediately after commencement of sucking.
  • the device is particularly suitable for use with an inward-charging, outward-discharging container, as mentioned above, since the force required to hold the head or stem in the inward position, and hence the force required to disengage the strut, is relatively small. It is however a significant advantage of the device that it may be arranged for use with outward charging, inward-discharging or continuous spray containers while still utilising a very simple construction of few parts. In order to ensure that a single discrete dose is emitted at or immediately after commencement of sucking, the strut, or means associated therewith, may be arranged to seal the outlet of the stem or head while the strut is in the engaged position.
  • the air pressure difference whereby the strut is disengaged may be detected by a pressure responsive device, which may be a vane in the duct.
  • the pressure difference may be detected by a device responsive to air flow in the duct resulting from said pressure difference.
  • a flow responsive device may comprise a hot-wire anemometer.
  • a plastics casing 51 has an outlet orifice 52 suitable for placing in the mouth of a user.
  • the casing 51 defines a recess 53 in which there is placed an aerosol type medicament dispenser 54.
  • the dispenser 54 has a stem or spray head 55 with an outlet orifice 56 in one side. Pressing stem 55 inwardly of the aerosol container causes a metering chamber (not shown) to be primed, and release of the stem allows a metered dose of medicament to issue from ori fice 56.
  • a press button 57 has a strut 58 integral therewith but pivotable about a flexible hinge.
  • the strut engages the end of the stem 55, so that when the press button is pushed inward then the stem is pressed into the dispenser 54 and the metering chamber is filled with medicament.
  • Attached to the strut 58 is a lever arm 59, and this in turn is engaged by a vane 61 pivoted to the body of the device at a hinge 62.
  • the vane 61 in its normal position as shown in the drawing blocks a duct within the casing 51 and extending between an air inlet 63 and the outlet orifice 52.
  • the strut 58 is provided with an extension 64 engageable with a spring loaded pin 65.
  • the rotation of the lever arm 59 and the strut 58 by the vane 61 depresses the pin 65, but when the press button 57 is thereafter released the pin tilts the strut back towards the stem 55 to engage it.
  • the embodiment described is suitable for use with any reservoir of the appropriate size and having a metering valve which is primed on the inward stroke of the stem and dispenses medicament on the outward stroke.
  • a metering valve which is primed on the inward stroke of the stem and dispenses medicament on the outward stroke.
  • One particular form of such a metering valve utilizes a hollow stem as the receptacle, and is charged by pressing the stem and spray head 55 inwardly past a stem seal until the orifice 56 is within the reservoir, whereupon medicament under pressure enters the hollow stem through the orifice, and subsequent release of the stem and spray head 55 dispenses the medicament.
  • This is, however, only one of several possible valve constructions. In some constructions the outlet orifice 56 is in the end ofthe stem, not the side.
  • the device of this example may be adapted for use with an outwardcharging, inward-discharging container, or a continuous spray container, by providing means which sea] the outlet orifice when the strut is in the engaged position shown.
  • pressing the strut inwardly will cause a dose of medicament to be stored in the spray stem, removal of the strut allowing the dose to escape through the outlet orifice of the stem.
  • the sealing means may for example comprise a sealing pad on the strut, or a piston carrying a sealing pad and interposed between the strut and the spray stem.
  • button 57 may be dispensed with, the relative movement of the strut towards the container being brought about by manual downward movement of the container.
  • An aerosol device comprising an aerosol container of the type which has a tubular valve stem and which on depression of the stem measures out a metered quantity of fluid ready for discharge through the stem when the stem is released, a duct which is in fluid con nection with the tubular valve stemand has one end open to atmosphere and the other end arranged for insertion into the mouth of a user, a two-part strut having a first part to engage the stem and a second part which is manually engageable to move the strut between an inoperative position in which the stem is released and an operative position in which the stem is depressed, a flow sensor in the duct, and means to move the first part of the strut out of engagement with the stem to release the stem when the flow sensor detects a flow of air in the duct when a user inhales through the duct, the arrangement being such that release of manual pressure from the second part of the strut will also release the stem.
  • a device as claimed in claim 1 in which the first part of the strut carries a projection which is engageable by the vane to move the said first part out of engagement with the stem.
  • a device as claimed in claim 1 in which the parts of the strut are pivotally connected together.
  • a device as claimed in claim 4 in which the two parts of the strut are spring biased into the position where the first part is engageable with the stem.
  • a device as claimed in claim 4 in which the two parts of the strut are integrally formed from plastics material.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Nozzles (AREA)
US00306950A 1971-11-25 1972-11-15 Inhalation actuated aerosol device for dispensing a metered quantity of fluid Expired - Lifetime US3814297A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5485271A GB1413285A (en) 1971-11-25 1971-11-25 Aerosol devices

Publications (1)

Publication Number Publication Date
US3814297A true US3814297A (en) 1974-06-04

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Family Applications (1)

Application Number Title Priority Date Filing Date
US00306950A Expired - Lifetime US3814297A (en) 1971-11-25 1972-11-15 Inhalation actuated aerosol device for dispensing a metered quantity of fluid

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US (1) US3814297A (enExample)
JP (1) JPS4860314A (enExample)
CA (1) CA990249A (enExample)
DE (1) DE2257759A1 (enExample)
FR (1) FR2163048A5 (enExample)
GB (1) GB1413285A (enExample)
IE (1) IE36835B1 (enExample)
IT (1) IT973697B (enExample)
NL (1) NL7215858A (enExample)
ZA (1) ZA728006B (enExample)

Cited By (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3935999A (en) * 1973-12-19 1976-02-03 Colgate-Palmolive Company Spray confining aerosol device
US4291688A (en) * 1979-01-11 1981-09-29 Schering Corp. Inhalation device
US4576157A (en) * 1983-10-24 1986-03-18 Raghuprasad Puthalath K Oral inhalation apparatus
US4664107A (en) * 1983-10-28 1987-05-12 Minnesota Mining And Manufacturing Company Inhalation activatable dispensers
US4803978A (en) * 1985-08-09 1989-02-14 Johnson Iv John J Apparatus for actuating an inhaler
US4819834A (en) * 1986-09-09 1989-04-11 Minnesota Mining And Manufacturing Company Apparatus and methods for delivering a predetermined amount of a pressurized fluid
US4852561A (en) * 1988-07-27 1989-08-01 Sperry C R Inhalation device
US5027808A (en) * 1990-10-31 1991-07-02 Tenax Corporation Breath-activated inhalation device
US5031610A (en) * 1987-05-12 1991-07-16 Glaxo Inc. Inhalation device
US5060643A (en) * 1990-08-07 1991-10-29 Tenax Corporation Breath-activated inhalation device
US5069204A (en) * 1989-08-23 1991-12-03 Riker Laboratories, Inc. Inhaler
US5119806A (en) * 1987-05-12 1992-06-09 Glaxo Inc. Inhalation device
US5217004A (en) * 1990-12-13 1993-06-08 Tenax Corporation Inhalation actuated dispensing apparatus
US5224472A (en) * 1990-02-09 1993-07-06 Solange Quenderff Inhalation device
US5232124A (en) * 1992-03-10 1993-08-03 Advanced Monobloc Corporation Pressure relief device and method
WO1994011044A2 (en) 1992-11-12 1994-05-26 Minnesota Mining And Manufacturing Company Powder inhaler
US5347998A (en) * 1990-07-09 1994-09-20 Minnesota Mining And Manufacturing Company Breath actuated inhaler having an electromechanical priming mechanism
US5392768A (en) * 1991-03-05 1995-02-28 Aradigm Method and apparatus for releasing a controlled amount of aerosol medication over a selectable time interval
US5394866A (en) * 1991-03-05 1995-03-07 Aradigm Corporation Automatic aerosol medication delivery system and methods
US5404871A (en) * 1991-03-05 1995-04-11 Aradigm Delivery of aerosol medications for inspiration
US5450336A (en) * 1991-03-05 1995-09-12 Aradigm Corporation Method for correcting the drift offset of a transducer
US5497763A (en) * 1993-05-21 1996-03-12 Aradigm Corporation Disposable package for intrapulmonary delivery of aerosolized formulations
US5497764A (en) * 1991-03-05 1996-03-12 Aradigm Corporation Medication cassette for an automatic aerosol medication delivery
US5509404A (en) * 1994-07-11 1996-04-23 Aradigm Corporation Intrapulmonary drug delivery within therapeutically relevant inspiratory flow/volume values
US5511540A (en) * 1992-08-18 1996-04-30 Minnesota Mining And Manufacturing Company Inhalation device
US5709202A (en) * 1993-05-21 1998-01-20 Aradigm Corporation Intrapulmonary delivery of aerosolized formulations
US6012454A (en) * 1989-04-28 2000-01-11 Minnesota Mining And Manufacturing Company Dry powder inhalation device
US6029661A (en) * 1991-08-26 2000-02-29 3M Innovative Properties Company Powder dispenser
WO2000029054A1 (en) 1998-11-16 2000-05-25 3M Innovative Properties Company Breath-actuated aerosol dispensers
US6260549B1 (en) 1998-06-18 2001-07-17 Clavius Devices, Inc. Breath-activated metered-dose inhaler
US6354290B1 (en) * 1998-12-11 2002-03-12 Bespak Plc Inhalation apparatus
US6415784B1 (en) * 1998-09-24 2002-07-09 Astrazeneca Ab Inhaler
US6475796B1 (en) 1999-05-20 2002-11-05 Scios, Inc. Vascular endothelial growth factor variants
WO2002088317A2 (en) 2001-05-01 2002-11-07 The Regents Of The University Of California Fusion molecules and methods for treatment of immune diseases
US6581804B1 (en) * 2002-01-11 2003-06-24 Joseph S. Kanfer Holder for aerosol dispenser
US6637432B2 (en) * 2000-05-09 2003-10-28 Iep Pharmaceutical Devices Inc. Inhalation actuated device
US20040020486A1 (en) * 2000-03-18 2004-02-05 Huxham Laurence Stanmore Inhaler
US20040241800A1 (en) * 1999-05-20 2004-12-02 Jue Rodney Alan Vascular endothelial growth factor dimers
US20050158394A1 (en) * 2000-02-28 2005-07-21 Vectura Limited Delivery of oral drugs
US20050209558A1 (en) * 2002-06-03 2005-09-22 Eduard Marx Dose indicators and dispensing canister-indicator assemblies
US20050274860A1 (en) * 2004-06-15 2005-12-15 Kunesh Edward J Wall mountable holder for a container
US20060171942A1 (en) * 2005-02-02 2006-08-03 Andrew Saxon Modified fusion molecules for treatment of allergic disease
WO2006097756A1 (en) * 2005-03-17 2006-09-21 Glaxo Group Limited Inhalation devices
US20060213505A1 (en) * 1997-11-14 2006-09-28 Astrazeneca Ab Inhalation device
USD529791S1 (en) 2004-06-15 2006-10-10 S.C. Johnson & Son, Inc. Wall mountable container holder
US20060231093A1 (en) * 2002-11-04 2006-10-19 Simon Burge Pressurised inhalers
EP2335726A1 (en) 2001-05-01 2011-06-22 The Regents of the University of California Fusion molecules and methods for treatment of immune diseases
US8021649B2 (en) 2007-02-22 2011-09-20 Cronk Peter J Continuous spray scalp therapy and dispensing systems for same
US20110303221A1 (en) * 2010-06-15 2011-12-15 Joerg Kohnle Inhaler
US8584668B2 (en) 1997-11-14 2013-11-19 Astrazeneca Ab Inhalation device
US8961992B1 (en) 2014-04-02 2015-02-24 Tunitas Therapeutics, Inc. Epsigam fusion protein
WO2015187918A2 (en) 2014-06-05 2015-12-10 The Regents Of The University Of California Halogenated ether compounds and methods of inducing anesthesia
US9849257B2 (en) * 2013-08-22 2017-12-26 Trudell Medical International Oscillating positive respiratory pressure device
EP4032533A1 (en) 2012-07-10 2022-07-27 The Regents of The University of California Methods of inducing anesthesia

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3229702A1 (de) * 1981-08-13 1983-03-03 Glaxo Group Ltd., London Medizinisches inhalationsgeraet
GB8319150D0 (en) * 1983-07-15 1983-08-17 Glaxo Group Ltd Aerosol applicator device
US6553988B1 (en) 2000-06-09 2003-04-29 Norton Healthcare, Inc. Medicament dispensing device with a multimaterial diaphragm bounding a pneumatic force chamber
EP1414508B1 (en) 2001-06-26 2011-04-20 Norton Healthcare Limited An improved aerosol actuator
US7296567B2 (en) 2002-09-25 2007-11-20 3M Innovative Properties Company Breath actuated aerosol dispensers

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3456644A (en) * 1967-01-19 1969-07-22 Dart Ind Inc Inhalation-actuated aerosol dispensing device
US3565070A (en) * 1969-02-28 1971-02-23 Riker Laboratories Inc Inhalation actuable aerosol dispenser

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3456644A (en) * 1967-01-19 1969-07-22 Dart Ind Inc Inhalation-actuated aerosol dispensing device
US3565070A (en) * 1969-02-28 1971-02-23 Riker Laboratories Inc Inhalation actuable aerosol dispenser

Cited By (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3935999A (en) * 1973-12-19 1976-02-03 Colgate-Palmolive Company Spray confining aerosol device
US4291688A (en) * 1979-01-11 1981-09-29 Schering Corp. Inhalation device
US4576157A (en) * 1983-10-24 1986-03-18 Raghuprasad Puthalath K Oral inhalation apparatus
US4664107A (en) * 1983-10-28 1987-05-12 Minnesota Mining And Manufacturing Company Inhalation activatable dispensers
US4803978A (en) * 1985-08-09 1989-02-14 Johnson Iv John J Apparatus for actuating an inhaler
US4819834A (en) * 1986-09-09 1989-04-11 Minnesota Mining And Manufacturing Company Apparatus and methods for delivering a predetermined amount of a pressurized fluid
US5031610A (en) * 1987-05-12 1991-07-16 Glaxo Inc. Inhalation device
US5119806A (en) * 1987-05-12 1992-06-09 Glaxo Inc. Inhalation device
US4852561A (en) * 1988-07-27 1989-08-01 Sperry C R Inhalation device
US6012454A (en) * 1989-04-28 2000-01-11 Minnesota Mining And Manufacturing Company Dry powder inhalation device
US5069204A (en) * 1989-08-23 1991-12-03 Riker Laboratories, Inc. Inhaler
US5224472A (en) * 1990-02-09 1993-07-06 Solange Quenderff Inhalation device
US5347998A (en) * 1990-07-09 1994-09-20 Minnesota Mining And Manufacturing Company Breath actuated inhaler having an electromechanical priming mechanism
US5060643A (en) * 1990-08-07 1991-10-29 Tenax Corporation Breath-activated inhalation device
US5027808A (en) * 1990-10-31 1991-07-02 Tenax Corporation Breath-activated inhalation device
US5217004A (en) * 1990-12-13 1993-06-08 Tenax Corporation Inhalation actuated dispensing apparatus
US5497764A (en) * 1991-03-05 1996-03-12 Aradigm Corporation Medication cassette for an automatic aerosol medication delivery
US5622162A (en) * 1991-03-05 1997-04-22 Aradigm Corporation Method and apparatus for releasing a controlled amount of aerosol medication over a selectable time interval
US5394866A (en) * 1991-03-05 1995-03-07 Aradigm Corporation Automatic aerosol medication delivery system and methods
US5404871A (en) * 1991-03-05 1995-04-11 Aradigm Delivery of aerosol medications for inspiration
US5450336A (en) * 1991-03-05 1995-09-12 Aradigm Corporation Method for correcting the drift offset of a transducer
US5743252A (en) * 1991-03-05 1998-04-28 Aradigm Corporation Method for releasing controlled amount of aerosol medication
US5826570A (en) * 1991-03-05 1998-10-27 Aradigm Corporation Delivery of aerosol medications for inspiration
US5392768A (en) * 1991-03-05 1995-02-28 Aradigm Method and apparatus for releasing a controlled amount of aerosol medication over a selectable time interval
US5655516A (en) * 1991-03-05 1997-08-12 Aradigm Corporation Delivery of aerosol medications for inspiration
US5520166A (en) * 1991-03-05 1996-05-28 Aradigm Corporation Medication cassette for an automatic aerosol medication delivery system
US5542410A (en) * 1991-03-05 1996-08-06 Aradigm Corporation Delivery of aeerosol medications for inspiration
US5755218A (en) * 1991-03-05 1998-05-26 Aradigm Corporation Method and apparatus for releasing a controlled amount of aerosol medication over a selectable time interval
US5608647A (en) * 1991-03-05 1997-03-04 Aradigm Corporation Method for releasing controlled amount of aerosol medication
US6029661A (en) * 1991-08-26 2000-02-29 3M Innovative Properties Company Powder dispenser
US6119688A (en) * 1991-08-26 2000-09-19 3M Innovative Properties Company Powder dispenser
US5232124A (en) * 1992-03-10 1993-08-03 Advanced Monobloc Corporation Pressure relief device and method
US5511540A (en) * 1992-08-18 1996-04-30 Minnesota Mining And Manufacturing Company Inhalation device
WO1994011044A2 (en) 1992-11-12 1994-05-26 Minnesota Mining And Manufacturing Company Powder inhaler
US5709202A (en) * 1993-05-21 1998-01-20 Aradigm Corporation Intrapulmonary delivery of aerosolized formulations
US5823178A (en) * 1993-05-21 1998-10-20 Aradigm Corporation Disposable package for use in aerosolized delivery of drugs
US5718222A (en) * 1993-05-21 1998-02-17 Aradigm Corporation Disposable package for use in aerosolized delivery of drugs
US5544646A (en) * 1993-05-21 1996-08-13 Aradigm Corporation Systems for the intrapulmonary delivery of aerosolized aqueous formulations
US6014969A (en) * 1993-05-21 2000-01-18 Aradigm Corporation Disposable package for use in aerosolized delivery of antibiotics
US5497763A (en) * 1993-05-21 1996-03-12 Aradigm Corporation Disposable package for intrapulmonary delivery of aerosolized formulations
EP1366778A2 (en) 1993-05-21 2003-12-03 Aradigm Corporation Systems for the intrapulmonary delivery of aerosolized aqueous formulations
US5509404A (en) * 1994-07-11 1996-04-23 Aradigm Corporation Intrapulmonary drug delivery within therapeutically relevant inspiratory flow/volume values
EP1310268A2 (en) 1994-07-11 2003-05-14 Aradigm Corporation Intrapulmonary drug delivery within therapeutically relevant inspiratory flow/volume values
US8584668B2 (en) 1997-11-14 2013-11-19 Astrazeneca Ab Inhalation device
US20060213505A1 (en) * 1997-11-14 2006-09-28 Astrazeneca Ab Inhalation device
US6260549B1 (en) 1998-06-18 2001-07-17 Clavius Devices, Inc. Breath-activated metered-dose inhaler
US6425392B1 (en) 1998-06-18 2002-07-30 Clavius Devices, Inc. Breath-activated metered-dose inhaler
US6318361B1 (en) 1998-06-18 2001-11-20 Clavius Devices Inc. Breath-activated metered-dose inhaler
US6325062B1 (en) 1998-06-18 2001-12-04 Clavius Devices, Inc. Breath-activated metered-dose inhaler
US6415784B1 (en) * 1998-09-24 2002-07-09 Astrazeneca Ab Inhaler
US6460537B1 (en) * 1998-11-16 2002-10-08 3M Innovative Properties Company Breath-actuated aerosol dispensers
WO2000029054A1 (en) 1998-11-16 2000-05-25 3M Innovative Properties Company Breath-actuated aerosol dispensers
US6354290B1 (en) * 1998-12-11 2002-03-12 Bespak Plc Inhalation apparatus
US20040241800A1 (en) * 1999-05-20 2004-12-02 Jue Rodney Alan Vascular endothelial growth factor dimers
US20030096754A1 (en) * 1999-05-20 2003-05-22 Pollitt N. Stephen Vascular endothelial growth factor variants
US6475796B1 (en) 1999-05-20 2002-11-05 Scios, Inc. Vascular endothelial growth factor variants
US6887848B2 (en) 1999-05-20 2005-05-03 Scios, Inc. Vascular endothelial growth factor variants
US20050119165A1 (en) * 1999-05-20 2005-06-02 Scios, Inc. Vascular endothelial growth factor dimers
US20050158394A1 (en) * 2000-02-28 2005-07-21 Vectura Limited Delivery of oral drugs
EP1941868A2 (en) 2000-02-28 2008-07-09 PharmaKodex Limited Improvements in or relating to the delivery of oral drugs
US20040020486A1 (en) * 2000-03-18 2004-02-05 Huxham Laurence Stanmore Inhaler
US6823863B2 (en) * 2000-03-18 2004-11-30 Astrazeneca Ab Inhaler
US6637432B2 (en) * 2000-05-09 2003-10-28 Iep Pharmaceutical Devices Inc. Inhalation actuated device
EP2335726A1 (en) 2001-05-01 2011-06-22 The Regents of the University of California Fusion molecules and methods for treatment of immune diseases
WO2002088317A2 (en) 2001-05-01 2002-11-07 The Regents Of The University Of California Fusion molecules and methods for treatment of immune diseases
US7032782B1 (en) * 2002-01-11 2006-04-25 Joseph S. Kanfer Holder for aerosol dispenser
US6581804B1 (en) * 2002-01-11 2003-06-24 Joseph S. Kanfer Holder for aerosol dispenser
US7464708B2 (en) 2002-06-03 2008-12-16 3M Innovative Properties Company Dose indicators and dispensing canister-indicator assemblies
US20050209558A1 (en) * 2002-06-03 2005-09-22 Eduard Marx Dose indicators and dispensing canister-indicator assemblies
US20060231093A1 (en) * 2002-11-04 2006-10-19 Simon Burge Pressurised inhalers
USD529791S1 (en) 2004-06-15 2006-10-10 S.C. Johnson & Son, Inc. Wall mountable container holder
US20050274860A1 (en) * 2004-06-15 2005-12-15 Kunesh Edward J Wall mountable holder for a container
US7261268B2 (en) 2004-06-15 2007-08-28 S.C. Johnson & Son, Inc. Wall mountable holder for a container
US20060171942A1 (en) * 2005-02-02 2006-08-03 Andrew Saxon Modified fusion molecules for treatment of allergic disease
US7488804B2 (en) 2005-02-02 2009-02-10 The Regents Of The University Of California Modified fusion molecules for treatment of allergic disease
US20090136493A1 (en) * 2005-02-02 2009-05-28 Andrew Saxon Modified fusion molecules for treatment of allergic disease
US20080168984A1 (en) * 2005-03-17 2008-07-17 Richard David Lintern Inhalation Device
WO2006097756A1 (en) * 2005-03-17 2006-09-21 Glaxo Group Limited Inhalation devices
US8021649B2 (en) 2007-02-22 2011-09-20 Cronk Peter J Continuous spray scalp therapy and dispensing systems for same
US20110303221A1 (en) * 2010-06-15 2011-12-15 Joerg Kohnle Inhaler
US8746238B2 (en) * 2010-06-15 2014-06-10 Aptar Radolfzell Gmbh Inhaler
EP4032533A1 (en) 2012-07-10 2022-07-27 The Regents of The University of California Methods of inducing anesthesia
US9849257B2 (en) * 2013-08-22 2017-12-26 Trudell Medical International Oscillating positive respiratory pressure device
US8961992B1 (en) 2014-04-02 2015-02-24 Tunitas Therapeutics, Inc. Epsigam fusion protein
US9109030B1 (en) 2014-04-02 2015-08-18 Tunitas Therapeutics, Inc. Epsigam fusion protein
WO2015187918A2 (en) 2014-06-05 2015-12-10 The Regents Of The University Of California Halogenated ether compounds and methods of inducing anesthesia

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AU4896872A (en) 1974-05-16
IT973697B (it) 1974-06-10
FR2163048A5 (enExample) 1973-07-20
IE36835L (en) 1973-05-25
NL7215858A (enExample) 1973-05-29
JPS4860314A (enExample) 1973-08-24
ZA728006B (en) 1974-06-26
CA990249A (en) 1976-06-01
DE2257759A1 (de) 1973-05-30
IE36835B1 (en) 1977-03-02
GB1413285A (en) 1975-11-12

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