US3760969A - Container closure - Google Patents

Container closure Download PDF

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Publication number
US3760969A
US3760969A US3760969DA US3760969A US 3760969 A US3760969 A US 3760969A US 3760969D A US3760969D A US 3760969DA US 3760969 A US3760969 A US 3760969A
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US
United States
Prior art keywords
closure member
opening
annular
covering plug
covering
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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English (en)
Inventor
Y Matsukura
O Kawahara
T Shimamoto
M Fujita
M Sakagami
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Takeda Pharmaceutical Co Ltd
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Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Publication of US3760969A publication Critical patent/US3760969A/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1406—Septums, pierceable membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/14—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor incorporating preformed parts or layers, e.g. injection moulding around inserts or for coating articles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/002—Closures to be pierced by an extracting-device for the contents and fixed on the container by separate retaining means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1468—Containers characterised by specific material properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2207/00—Methods of manufacture, assembly or production
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C43/00—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor
    • B29C43/32—Component parts, details or accessories; Auxiliary operations
    • B29C43/34—Feeding the material to the mould or the compression means
    • B29C2043/3444—Feeding the material to the mould or the compression means using pressurising feeding means located in the mould, e.g. plungers or pistons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C43/00—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor
    • B29C43/02—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor of articles of definite length, i.e. discrete articles
    • B29C43/18—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor of articles of definite length, i.e. discrete articles incorporating preformed parts or layers, e.g. compression moulding around inserts or for coating articles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/56—Stoppers or lids for bottles, jars, or the like, e.g. closures
    • B29L2031/565—Stoppers or lids for bottles, jars, or the like, e.g. closures for containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/753—Medical equipment; Accessories therefor
    • B29L2031/7544—Injection needles, syringes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S215/00—Bottles and jars
    • Y10S215/03—Medical

Definitions

  • ABSTRACT A container closure member adapted to sealably close an access opening of a glass bottle for solutions, which has a leg-like portion sealingly situated in the access opening.
  • This closure member comprises a rubber covering plug formed with an annular protrusion and a shaped form of synthetic resin formed with an annular groove and firmly contacted with the covering plug with its annular groove receiving thereinthe annular protrusion of the covering plug.
  • the diameter of the shaped form is smaller than that of a flange of the storage vessel, but larger than that of the access opening so that a tight contact between the closure member and the storage vessel can be advantageously ensured.
  • the present invention relates to an improved closure member for solution containers and, more particularly, to a pierceable closure member for medicine bottles and a method of forming the same.
  • closure member for containers containing therein medical injection solutions or other valuable medical solutions.
  • the closure member of the type above referred to should have a relatively higher quality so that the valuable solution contained therein cannot be contaminated by material and/or additives employed to manufacture such closure member.
  • closure member closing a medical container such as vial or the like contaminates the solution contained therein in such a way that material and/or additives employed to manufacture such closure member has been desolved into the solution and/or that some of the additives have been adsorb to a surface portion of the closure member accessible to the solution, some or all of the characteristics, for example, the potency, the colour and the pH, of the solution will be degraded.
  • exemplary types of the closure member are such as disclosed in the U.S. Pat. Nos. 3,198,368 and 3,552,591, of which a common feature resides in the employment of a disc-like film of Teflon that is contacted with the relevant surface of a rubber covering or backing member during the process of vulcanization of the latter.
  • the first numbered U.S. patent is directed to a closure member apparently designed such that the Teflon disc of a diameter substantially equal to that of the rubber backing'is contacted with one whole surface of the rubber backing which is adapted to cover the opening-of a solution container, whereas the second numbered U.S.
  • the Teflon disc has adiameter smaller than that of the rubber covering member, but larger than that of the opening of a solution container to be closed thereby, so as to contact a substantially central portion of the relevant surface of the rubber covering member, the rubber covering member is provided at its outer periphery or rim with a downwardly extending annular ridge engageable with the bevel-shaped upper peripheral edge of the flange formed around a neck portion of the solution container.
  • the closure member as disclosed in the second numbered U.S. patent has many advantages over that disclosed in the first numbered U.S. patent.
  • this closure member of the second numbered U.S. patent is very complicated so that the container of special construction nust be provided to enable the closure member to exhibit its excellent performance.
  • the existing container forming equipment must be remodeled, or otherwise new container forming equipment must be provided for manufacturing the container of which the flange at the neck portion can accommodate the clo sure member such as disclosed in the second numbered U.S. patent.
  • This closure member is similarly in the form of substantially flat structure and, toavoid thedepression at the central portion thereof, an annular groove is also formed on the relevant surface of the closure member at a position slightly spaced from the outermost rim or periphery of said closure member.
  • an annular groove is also formed on the relevant surface of the closure member at a position slightly spaced from the outermost rim or periphery of said closure member.
  • an essential object of the present invention is to provide an improved pierceable closure mem ber for solution containers wherein the above mentioned disadvantages inherent in the conventional closure member of this kind have substantially been eliminated.
  • Another object of the present invention is to provide an improved pierceable closure member for solution containers which prevents the contamination of a valuable medical or other solution contained in the container nor the loss of chemicals stored in said container.
  • a further object of the present invention is to provide an improved pierceable closure member for solution containers which prevents the leakage of a valuable medical or other solution stored in the container.
  • a container for medical injection solutions comprising a storage vessel with a defined access opening and a closure member adapted to tightly close said access opening.
  • the closure member is formed on one surface adjacent to the access opening of the storage vessel integrally with a leg-like structure adapted to sealably inserted in the access opening, and includes a rubber covering plug formed with an annular protrusion and a shaped form made from a film of synthetic material and formed with an annular groove or recess in which said annular protrusion is tightly situated, said annular protrusion and said annular groove constituting the leglike portion of the closure member.
  • the diameter of the shaped form is smaller than that of the covering plug, but larger than the diameter of the access opening so that a tight contact between the closure member to the storage vessel can be ensured without any possible occurrence of leakage of a solution contained in the container.
  • the shaped form is firmly contacted with the covering plug to an extent that, even if a needle is pierced through'the closure member very often in a violent manner, no-detachment of the shaped form from the covering plug takes place.
  • one surface of the shaped form to be contacted with the covering plug is roughened by the treatment with a natrium containing solution to permit the raw rubber material for the covering plug to compensate the roughness on the surface of the shaped form during the molding operation.
  • the leg-like portion of the closure member is inwardly ressed on the outside periphery thereof at a position adjacent to the root with the inside periphery being tapered in the direction opposite to the access opening so that, in addition to the tight contact between the covering plug and the storage vessel, another tight contact can be obtained between a portion adjacent to the free end of said leg-like portion of the closure member and the storage vessel. Since the double contacts can be available, the tightness of the con tainer can be substantially improved.
  • the present invention also pertains to a method of manufacturing the closure member wherein each closure member can be obtained by molding and vulcanizing a raw rubber material in a cavity of a molding machine which defines the shape of the resultant closure member.
  • streams of raw rubber material are directed to the outer peripheral edge of each of the forms lying in the mold so that no warping of the peripheral edge of the form will occur during the molding operation.
  • FIG. 1. is aschcmatic longitudinal section of an upper portion of a medicine bottle of which the opening is closed by a closure member constructed in accordance with the present invention
  • FIG. 2 is a similar view to FIG. 1, showing another preferred embodiment of the present invention
  • FIG. 3 is a'schematic diagram showing a molding machine for manufacturing the closure member shown in FIG. 1 and,
  • FIG. 4 is a schematic diagram showing a molding machine for manufacturing the closure member shown in FIG. 2.
  • a solution container for example, a medicine bottle 1 made of glass or other rigid materials as have been conventionally accepted and in cooperation with which the present invention can be practically utilized has an opening or mouth 2 defined by a neck portion 3, an uppermost portion of said neck portion 3 being integrally formed with a flange 4 of suitable thickness.
  • the medicine bottle 1 is shown as having a closure member, generally indicated by 5 and constructed in accordance with the teachings of the present invention as will be mentioned later, fastened thereto so as to tightly close the bottle opening 2 by means of a metal sealing ring 6 which is fitted over the periphery of the closure memedge of the form 8 of FIG. 2 which is suspended over the bottle flange 4 is substantially the same as hereinbefore described.
  • the size of the peripheral edge of the form 8 of FIG. 2 is defined by the difference between the diameter D of the form 8 and the diameter d, of the bottle opening 2.
  • the minimum outside diameter, as indicated by D 'of the form 8, which is slightly larger than the outside diameter of the protrusion 7a at a position substantially adjacent to the outside root thereof, is, in view of the provision of the recessed gap 9, smaller than the outside diameter, as indicated by D located adjacent to the annular free end of said protrusion 7a.
  • the outside diameter D2 may be substantially equal to or slightly larger than the diameter d, of the bottle opening 2.
  • the diameter D is slightly larger than the diam eter d insertion of the closure member '5 or, more specifically, the annular protrusion 7a, in the bottle opening 2 causes said protrusion to be compressed in the peripheral direction so that, in addition to the tight contact between the covering plug 7 and the bottle flange 4 through the uncovered area 70, another tight contact between the closure member 5 and the bottle 1 can be advantageously obtained.
  • This is because, as can be understood by those skilled in the art, upon compression of the annular protrusion 7a, stress can be exerted about the annular free end of said protrusion in the radial direction to an extent that the tight contact can be ensured.
  • the size of the recessed gap 9 is such that the ratio of the difference between the diameters D and D to the diameter D, is within the range of from one one-hundreth to ten one-hundreths and the radius of rounding is within the range of from 0.1 to 2.0 mm., preferably, 0.3 to 1.0 mm.
  • This recessed gap 9 may be present or not present when the closure member 5 is inserted in the bottle opening 2.
  • the provision of the recessed gap 9 is effective to ensure the tight contact between the covering plug 7 and the form 8 in view of the fact that the skirt-like annular protrusion 7a situated in the annular groove 8a of the form 8 which meets the contour of the protrusion 7 'a carries said form 8 from the inside of the latter. Accordingly, it is apparent that, even if the surface of the form 8 has been insufficiently treated with the natrium containing solution, a possible detachment of the form 8 from the covering plug 7 can be substan tially completely eliminated. Without the provision of this recessed gap 9, the performance of the closure member shown in FIG. 2 is substantially the same as that of FIG. 1, since a difference merely exists in the construction of the inside peripheral surface of the annular protrusion. I
  • FIGS. 3 and 4 wherein a molding machine is schematically shown as including a female mold A, a male mold B and a hydraulically operated ram C, all being separable from each other.
  • the female mold A is provided at its depth with a plurality of equally spaced annular groove 10, each of which corresponds to the annular protrusion of the closure member 5 and having the shape which meets the contour of the form 8 and thus the annular protrusion.
  • the male mold B is formed with a plurality of cavities 11 for determining the shape of the covering plug during the molding operation, the number of which corresponds to that of the annular grooves 10; Each cavity 11 is communicated with a pot-like portion 12 formed in said male mold B for receiving therein a substantial amount of raw rubber material, through a plurality of passages 13 each having a diameter of the value within the range of from 0.5 to 1 mm.
  • the molding machine shown is of a design effective to vulcanize the raw rubber material during the molding operation.
  • a plurality of the forms 8 that have been prefabricated with its relevant surface treated with the natrium containing solution as hereinbefore described are first placed on the female mold A with the annular groove 8a of each of the forms 8 being received in the corresponding one of theannular groove 10 of said female mold A. Thereafter, the male mold B is tightly sealed with the female mold A and a substantial amount of raw rubber material for the covering plug 7 is subsequently filled in the pot-like portion 12 of the male mold B.
  • This supply of the raw rubber material may be made manually or by means of a pumping device (not shown).
  • the ram C is then moved toward the male mold B so that the raw rubber material in the potlike portion 12 can be poured under pressure into the cavities 11 through the passages 13 and then the annular grooves 8a of the forms 8 and, thereafter, the raw rubber material contained in the cavities I1 is subjected to vulcanization.
  • the units A, B and C are separated from each other and a plurality of the closure members 5 can be obtained by removing them from the male mold B.
  • each of the passages 13 facing to the cavity 11 is designed so as to position above the peripheral edge of the form 8, streams of the raw rubber material under pressure pouring from the pot-like portion 12 into the cavity 1 1 through the passage 13'act to restrict the peripheral edge of the form 8 from being warped.
  • each of the annular grooves 10 of the female mold A is substantially equal to the height of the annular protrusion or 7a.
  • the machine shown in FIG. 3 is adapted to manufacture the closure member shown in FIG. 1 while that shown in FIG. 4 is adapted to manufacture the closure member shown in FIG. 2.
  • the most important feature of the present invention resides in the location of the opening of each passage 13 facing to the cavity 11 substantially as hereinbefore described.
  • the medicine bottle 1 having such closure member 5 may be of any type, for example, a container for a medical injection solution, a corrosive solution or other valuable solution which is to be used in installments by repeatedly sticking the needle of a syringe through the closure member 5 or to be stored for a fairly long period of time.
  • the closure member 5 generally comprises a covering plug 7 made of natural rubber or a synthetic rubber such as polyisoprene or chloroprene and imparted with relatively higher elasticity, strength and softness, and a form 8 made of a fluorocarbon resin such as trifluorochloroethylene polymer, tetrafluoroethylene polymer or tetrafluoroethylene hexafluoropropylene copolymer.
  • a covering plug 7 made of natural rubber or a synthetic rubber such as polyisoprene or chloroprene and imparted with relatively higher elasticity, strength and softness
  • a form 8 made of a fluorocarbon resin such as trifluorochloroethylene polymer, tetrafluoroethylene polymer or tetrafluoroethylene hexafluoropropylene copolymer.
  • the covering plug 7 is integrally formed with an annular protrusion 7a of a height within the range of from 0.5 to 5 mm. which is sealably engageable in the bottle opening 2 and with a shallow recess 7b at a substantially central portion of the upper surface of said covering plug 7, said shallow recess 7b being adapted to define an area through which the needle or the like can be pierced.
  • This covering plug 7 of the above construction has the shape substantially as shown, which can be obtained by an extrusion molding process as will be mentioned later.
  • This form can be obtained by heatpressing a thin film of a fluoro-carbon resin for about one minute under a temperature of approximately 250 and, thereafter, by perforating the thin film thus heatpressed to give such form 8.
  • the covering plug 7 and the form 8 are tightly contacted to each other in such a way that the annular protrusion 7a of the covering plug 7 is situated within the annular groove 8a of the form 8.
  • no adhesive agent is employed, but the whole surface of the form 8 in contact with the adjacent surface of the covering plug 7 has been treated with a natrium containing solution to impart roughness on said surface of said form 8, so that, during the formation of the closure member in accordance with the method of the present invention, the roughness on said surface of said form 8 can be substantially completely filled up with raw rubber material employed to form the covering plug 7.
  • the diameter D of the form 8 should be smaller than the diameter d of the flange 4 which defines the bottle opening 2 of the diameter as indicated by d,, but larger than the diameter d, of said opening 2, so that an annular uncovered area 7c is provided on the surface of the covering plug 7 at a position between the outermost peripheral edge of the form 8 and the outermost peripheral edge of the covering plug 7.
  • This uncovered area 7c of the covering member 7 is adapted, when the closure member 5 is in position as shown, to directly contact the relevant portion of the flange 4.
  • the difference between the diameter d of the flange 4 and the diameter D of the form 8, namely, the distance between the outermost peripheral edges of the flange 4 and the covering plug 7 is preferably within the range of from one thirds to two third (one-third to two-thirds) of the difference between the diameter d of the flange 4 and the diameter d, of the bottle opening 2. If the direct contact area between the covering plug 7 and the bottle 1 or the bottle flange 4 is reduced in such a way that the difference between the diameter d and the diameter D becomes smaller than that of one-third of the difference between the diameter d and the diameter d a sufficient fluidtightness can no longer be imparted between the closure member 5 and the bottle 1.
  • the outside diameter of the annular protrusion 7a of the covering plug 7 is substantially equal to the diameter d, of the bottle opening 2 so that the whole outside peripheral surface of the protrusion 7a may contact the inner peripheral surface of the neck portion 3 of the bottle 1, a similar annular protrusion of the outside diameter slightly larger than the diameter of the bottle opening may be utilized.
  • the annular protrusion 7a integral with the covering plug 7 is inwardly recessed at a position substantially adjacent to the outside annular root of said protrusion to give a recessed gap 9 while the inside peripheral surface 7d of the protrusion 7a is preferably tapered toward the opposite, inside annular root of said protrusion to represent a skirt-like shape.
  • the outside diameter of the protrusion 7a at a position substantially adjacent to the outside root thereof is smaller than that am position where the protrusion 7a is to be indirectly contacted with the inner peripheral surface of the neck portion 3 of the bottle 1 through the form 8.
  • the form 8 is correspondingly shaped so as to meet the contour of the covering plug 7 and contacted to the latter in the same manner as described in connection with the first preferred embodiment with reference to FIG. 1.
  • the size of the peripheral To show theperformance of the closure member of the present invention, reference will be made to the following example which is not intended to limit the present invention in any respect.
  • EXAMPLE A film of tetrafluoroethylene copolymer, 0.13 mm. in thickness was treated on its one surface with a halogeneliminator containing solution which had been prepared by mixing a solution containing tetrahydrofuran and naphthalin with a dispersion containing natrium or metallic natrium of the same mole as that of the naphthalin for approximately minutes. After this film had been washed with aceton and then water and dried, the film was molded by means of a press, heated up to 250 and, after one minute, cooled down to 180, to give the molded form 8 of the shape substantially are shown in FIG. 2. The dimensions of this form 8 including the radius of rounding of the recessed gap 9 are:
  • Diameter 1) 16.0 mm. Diameter D, 12.2 mm. Diameter 1), 13.3 mm. Radius of Rounding 0.4 mm.
  • the form 8 thus obtained was placed on the female mold A shown in FIG. 4 and, in accordance with the procedure as hereinbefore described, the closure member, 19.0 mm. in diameter and 3.0 mm. in thickness,
  • Extract-permeability Test This is a test to determine to what extent distilled water, contained in each glass vial at the rate of 5 ml. and heated up to 100 for one hour, was contaminated by the composition of the closure member. The result of this test is expressed in the Table I in terms of UV adsorbance relative to the specific wavelength employed.
  • Adsorption Test This is a test to determine to what extent the closure member adsorbs a specified compound of a solution of 5 ml. contained in each glass vial. For this compound, 0.01 percent of propylparaben and 0.1 percent of methylparaben were respectively employed. In this example, each glass vial containing the solution was allowed to stand for days under room temperature, and the degree of adsorption is expressed in the Table I in terms of percentage. Note: For comparision, each glass vial having the closure member without the form 8 contacted to the covering plug 7 was also subjected to the same tests. In addition, all of the glass vials were tested in the inverted condition.
  • composition of raw rubber material for the closure member are as follows:
  • composition A Polyisoprene part 100 parts Zinc flower 5 parts Sulphur 1.5 parts 'Benzothiazolyl disulfide 1 part Stearic acid 1 part Silica 30 parts Composition B Chloroprene 100 parts Zinc flower 5 parts Magnesia 4 parts Ethylenethiourea 0.5
  • a container for medical injection solutions comprising a storage vessel with a defined access opening and a closure member, said closure member comprising a form composed of a thin film of a fluorocarbon resin and capable of sealably closing said opening and formed with an annular recessed portion adapted to be situated in said opening when said form is sealably covering said opening, a rubber covering plug pierceable by a hypodermic needle and formed with an annular protrusion adapted to be received in said annular recessed portion of said form, said annular protrusion being inwardly recessed at a position adjacent to the point at which said protrusion is integrally connected with the remainder of said covering plug, whereby are:
  • a container as claimed in claim 1 wherein said annular protrusion of said covering plug has its inside peripheral surface flared in the direction away from the access opening of the storage vessel.
  • a container as claimed in claim 7 wherein said fluorocarbon resin is selected from the group consisting of a trifluorochloroethylene polymer, a tetrafluoroethylene polymer and a tetrafluoroethylene-hexafluoropropylene copolymer.

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  • Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Manufacturing & Machinery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Casting Or Compression Moulding Of Plastics Or The Like (AREA)
  • Closures For Containers (AREA)
  • Lining Or Joining Of Plastics Or The Like (AREA)
  • Moulds For Moulding Plastics Or The Like (AREA)
US3760969D 1970-09-16 1971-09-10 Container closure Expired - Lifetime US3760969A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8104370A JPS549119B1 (de) 1970-09-16 1970-09-16

Publications (1)

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US3760969A true US3760969A (en) 1973-09-25

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US3760969D Expired - Lifetime US3760969A (en) 1970-09-16 1971-09-10 Container closure

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US (1) US3760969A (de)
JP (1) JPS549119B1 (de)
CH (1) CH531347A (de)
DE (1) DE2146421A1 (de)
FR (1) FR2106567B1 (de)
GB (1) GB1342975A (de)
IT (1) IT942607B (de)
NL (1) NL7112762A (de)

Cited By (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3938035A (en) * 1974-07-16 1976-02-10 Nasa Electrical conductivity cell and method for fabricating the same
US4066183A (en) * 1977-02-24 1978-01-03 L. C. Company, Inc. Chromatographic septum having polyimide coating
US4111326A (en) * 1976-03-04 1978-09-05 Becton, Dickinson And Company Closure for air evacuated container
US4142940A (en) * 1975-09-13 1979-03-06 W. C. Heraeus Gmbh Cultivation containers for cultures, microorganisms, cells, tissue and the like
US4186840A (en) * 1976-03-04 1980-02-05 Becton, Dickinson And Company Cannulapierceable, self-sealing closure
US4321306A (en) * 1978-11-17 1982-03-23 Tsukasa Eguchi Rubber stopper for tight sealing
US4362255A (en) * 1980-10-24 1982-12-07 Liqui-Box Corporation Barrier spout and cap for flexible bags or pouches
US4366912A (en) * 1980-02-25 1983-01-04 Takeda Chemical Industries, Ltd. Rubber closure device for vials
DE3231179A1 (de) * 1981-08-24 1983-03-24 Daikyo Gomu Seiko, Ltd., Tokyo Durchstechbares verschlusselement fuer einen behaelter, insbesondere eine medizinflasche
US4397706A (en) * 1974-05-24 1983-08-09 The West Company Method for making molded articles
US4397903A (en) * 1979-01-18 1983-08-09 The West Company Molded articles
US4482069A (en) * 1982-01-30 1984-11-13 Gesepa Anstalt Fur Patentverwertung Cap closure including pierceable sealing element
US4554125A (en) * 1983-03-17 1985-11-19 Schering Corporation Method of making a stopper for a sterile fluid container
US4614276A (en) * 1984-05-22 1986-09-30 Daikin Industries Laminated rubber stopper
EP0204486A2 (de) * 1985-05-28 1986-12-10 Daikyo Gomu Seiko Ltd. Harzlaminierter Kunststoffstopfen und dessen Herstellung
US4635807A (en) * 1983-03-17 1987-01-13 Schering Corporation Stopper for sterile fluid containers
US4724028A (en) * 1983-04-15 1988-02-09 Baxter Travenol Laboratories Method of manufacturing disc-shaped rubber articles, such as injection sites
US4995521A (en) * 1988-03-03 1991-02-26 Pohl Gmbh & Co. Kg Stopper for infusion and transfusion bottles
US5163919A (en) * 1988-08-25 1992-11-17 Helvoet Pharma N.V. Obturating means for container for pharmaceutical and medical preparation
WO1993004951A1 (en) * 1991-08-28 1993-03-18 Habley Medical Technology Corporation Non-reactive composite sealing barrier
US5219083A (en) * 1992-04-02 1993-06-15 Sterling Winthrop Inc. Stopper for reduction of particulate matter
US5244635A (en) * 1992-06-19 1993-09-14 Cirrus Diagnostics, Inc. Centrifuge vessel with coaxial waste chamber having cap to prevent waste fluid transfer from the chamber into the vessel
WO1995024301A1 (en) * 1994-03-07 1995-09-14 Wheaton Inc. Partially laminated rubber closure
WO1996026751A1 (en) * 1995-03-02 1996-09-06 Sanofi Winthrop, Inc. Low friction coating for cartridge seal cap
EP0705673A3 (de) * 1994-09-26 1997-05-07 Becton Dickinson Co Medizinische Gegenstand und Verfahren dafür
EP0899074A2 (de) * 1997-08-26 1999-03-03 Ecowater Systems, Inc. Kunststoffbeschichteter Ventil-Rotor und Verfahren zu dessen Herstellung
US20020048669A1 (en) * 1999-01-29 2002-04-25 Masamichi Sudo Molding die assembly for rubber members and rubber member produced thereby
AU746652B2 (en) * 1998-01-30 2002-05-02 Abbott Laboratories Method for making a stopper
US20020113033A1 (en) * 2000-04-06 2002-08-22 Claessens Albert Louis Victor Jozef Moulding suitable for pharmaceutical applications and method for production thereof
US20020187077A1 (en) * 2000-02-02 2002-12-12 Soltec, Inc. Flexible septa closure plug mats for well plate mounted arrays of sample vials
US6558628B1 (en) * 1999-03-05 2003-05-06 Specialty Silicone Products, Inc. Compartment cover, kit and method for forming the same
US20040035816A1 (en) * 2000-12-04 2004-02-26 Tadashi Okiyama Plug body for medical fluid container
US20040108294A1 (en) * 2002-08-12 2004-06-10 Bloom Kenneth S. Plastic closure, closure and container package, and method of manufacture
EP1457429A2 (de) 2003-03-14 2004-09-15 Helvoet Pharma Belgium N.V. Für pharmazeutische Verwendung dienende Überkappe mit Verschlussstopfen
US20050167390A1 (en) * 2001-12-10 2005-08-04 Hans-Dieter Dubs Container, particularly a beverage bottle
US20060151424A1 (en) * 2002-08-30 2006-07-13 Takiko Nakada Plug for container and method of producing the same
US20060203048A1 (en) * 2005-03-14 2006-09-14 Scheffelin Joseph E Plug
US20080229569A1 (en) * 2007-03-22 2008-09-25 Epoli - Espumas De Polietileno Sa Synthetic closure with multiple internal layers, each layer having a variable cross section (VCS) along the closure length
US20090223986A1 (en) * 2008-02-10 2009-09-10 Xubin Song Preservation container cover
US7611026B1 (en) 2002-08-12 2009-11-03 Rexam Closure Systems Inc. Tamper-evident closure having a sealing disk and package for high-temperature applications
US20090308184A1 (en) * 2008-03-05 2009-12-17 Becton, Dickinson And Company Co-Molded Pierceable Stopper and Method for Making the Same
US20100206836A1 (en) * 2007-10-18 2010-08-19 Tsuyoshi Koshidaka Vial rubber-stopper
US20100226747A1 (en) * 2009-03-09 2010-09-09 Japan Super Quartz Corporation Closure for silica glass crucible, silica glass crucible and method of handling the same
US20100264139A1 (en) * 2007-12-26 2010-10-21 Daikyo Seiko, Ltd. Molded rubber article
EP2250992A1 (de) * 2009-05-13 2010-11-17 Hubei Huaqiang High-Tech Co., Ltd. Teilweise mit PET-Folie beschichteter Gummistopfen und dessen Herstellungsverfahren
US20110001269A1 (en) * 2009-07-01 2011-01-06 Murena Denis Device for producing pin-shaped end products by the injection-molding process
US20110024438A1 (en) * 2008-01-15 2011-02-03 Anheuser Busch Inbev S.A. Assembly of a container and a closure
US20110024429A1 (en) * 2008-01-15 2011-02-03 Anheuser Busch Inbev S.A. Assembly of a container and a closure
US20110024422A1 (en) * 2008-01-15 2011-02-03 Anheuser Busch Inbev S.A. Closure
US20110061795A1 (en) * 2009-09-16 2011-03-17 Lonstroff Ag Method for producing a stopper
US8460620B2 (en) 2010-12-03 2013-06-11 Becton, Dickinson And Company Specimen collection container assembly
CN106742628A (zh) * 2017-01-09 2017-05-31 成都迅德科技有限公司 一种医用胶塞
US11944434B2 (en) 2008-03-05 2024-04-02 Becton, Dickinson And Company Capillary action collection device and container assembly

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DE3346351A1 (de) * 1983-12-22 1985-07-11 Pharma-Gummi Wimmer West Gmbh, 5180 Eschweiler Pharmazeutischer stopfen, kolben od. dgl. und verfahren zum herstellen von pharmazeutischen stopfen, kolben od. dgl.
JP2000202838A (ja) * 1999-01-11 2000-07-25 Daikyo Seiko Ltd ラミネ―トゴム要素の製造方法及びラミネ―トゴム要素
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US4397706A (en) * 1974-05-24 1983-08-09 The West Company Method for making molded articles
US3938035A (en) * 1974-07-16 1976-02-10 Nasa Electrical conductivity cell and method for fabricating the same
US4142940A (en) * 1975-09-13 1979-03-06 W. C. Heraeus Gmbh Cultivation containers for cultures, microorganisms, cells, tissue and the like
US4290534A (en) * 1976-03-04 1981-09-22 Becton, Dickinson And Company Cannula pierceable self-sealing closure
US4301936A (en) * 1976-03-04 1981-11-24 Becton, Dickinson And Company Cannula pierceable self-sealing closure
US4186840A (en) * 1976-03-04 1980-02-05 Becton, Dickinson And Company Cannulapierceable, self-sealing closure
US4187952A (en) * 1976-03-04 1980-02-12 Becton, Dickinson And Company Cannula pierceable, self-sealing closure
US4226333A (en) * 1976-03-04 1980-10-07 Becton, Dickinson And Company Cannula pierceable self-sealing closure
US4111326A (en) * 1976-03-04 1978-09-05 Becton, Dickinson And Company Closure for air evacuated container
US4295572A (en) * 1976-03-04 1981-10-20 Becton, Dickinson And Company Cannula pierceable self-sealing closure
US4136794A (en) * 1976-03-04 1979-01-30 Becton, Dickinson And Company Cannula pierceable, self-sealing closure
US4066183A (en) * 1977-02-24 1978-01-03 L. C. Company, Inc. Chromatographic septum having polyimide coating
US4321306A (en) * 1978-11-17 1982-03-23 Tsukasa Eguchi Rubber stopper for tight sealing
US4397903A (en) * 1979-01-18 1983-08-09 The West Company Molded articles
US4366912A (en) * 1980-02-25 1983-01-04 Takeda Chemical Industries, Ltd. Rubber closure device for vials
US4362255A (en) * 1980-10-24 1982-12-07 Liqui-Box Corporation Barrier spout and cap for flexible bags or pouches
DE3231179A1 (de) * 1981-08-24 1983-03-24 Daikyo Gomu Seiko, Ltd., Tokyo Durchstechbares verschlusselement fuer einen behaelter, insbesondere eine medizinflasche
US4441621A (en) * 1981-08-24 1984-04-10 Takeda Chemical Industries, Ltd. Pierceable closure member for vial
US4482069A (en) * 1982-01-30 1984-11-13 Gesepa Anstalt Fur Patentverwertung Cap closure including pierceable sealing element
US4635807A (en) * 1983-03-17 1987-01-13 Schering Corporation Stopper for sterile fluid containers
US4554125A (en) * 1983-03-17 1985-11-19 Schering Corporation Method of making a stopper for a sterile fluid container
US4724028A (en) * 1983-04-15 1988-02-09 Baxter Travenol Laboratories Method of manufacturing disc-shaped rubber articles, such as injection sites
US4614276A (en) * 1984-05-22 1986-09-30 Daikin Industries Laminated rubber stopper
EP0204486A2 (de) * 1985-05-28 1986-12-10 Daikyo Gomu Seiko Ltd. Harzlaminierter Kunststoffstopfen und dessen Herstellung
EP0204486A3 (en) * 1985-05-28 1987-12-09 Daikyo Gomu Seiko Ltd. Resin-laminated rubber plugs and manufacture thereof
US4915243A (en) * 1985-05-28 1990-04-10 Daikyo Gomu Seiko, Ltd. Resin-laminated rubber closure for a medical vial
US5078941A (en) * 1985-05-28 1992-01-07 Daikyo Gomu Sekio Ltd. Process for the production of a resin-laminated rubber closure for a medical vial
US4995521A (en) * 1988-03-03 1991-02-26 Pohl Gmbh & Co. Kg Stopper for infusion and transfusion bottles
US5163919A (en) * 1988-08-25 1992-11-17 Helvoet Pharma N.V. Obturating means for container for pharmaceutical and medical preparation
WO1993004951A1 (en) * 1991-08-28 1993-03-18 Habley Medical Technology Corporation Non-reactive composite sealing barrier
US5279606A (en) * 1991-08-28 1994-01-18 Habley Medical Technology Corporation Non-reactive composite sealing barrier
US5219083A (en) * 1992-04-02 1993-06-15 Sterling Winthrop Inc. Stopper for reduction of particulate matter
WO1994000762A1 (en) * 1992-06-19 1994-01-06 Cirrus Diagnostics, Inc. Centrifuge vessel for automated solid-phase immunoassay
US5244635A (en) * 1992-06-19 1993-09-14 Cirrus Diagnostics, Inc. Centrifuge vessel with coaxial waste chamber having cap to prevent waste fluid transfer from the chamber into the vessel
WO1995024301A1 (en) * 1994-03-07 1995-09-14 Wheaton Inc. Partially laminated rubber closure
US5484566A (en) * 1994-03-07 1996-01-16 Wheaton Inc. Method of manufacture of a partially laminated rubber closure
EP0705673A3 (de) * 1994-09-26 1997-05-07 Becton Dickinson Co Medizinische Gegenstand und Verfahren dafür
WO1996026751A1 (en) * 1995-03-02 1996-09-06 Sanofi Winthrop, Inc. Low friction coating for cartridge seal cap
EP0899074A3 (de) * 1997-08-26 1999-03-10 Ecowater Systems, Inc. Kunststoffbeschichteter Ventil-Rotor und Verfahren zu dessen Herstellung
EP0899074A2 (de) * 1997-08-26 1999-03-03 Ecowater Systems, Inc. Kunststoffbeschichteter Ventil-Rotor und Verfahren zu dessen Herstellung
US6085788A (en) * 1997-08-26 2000-07-11 Ecowater Systems, Inc. Plastic coated valve rotor and a method of manufacturing
CN100422607C (zh) * 1997-08-26 2008-10-01 埃科沃特系统有限责任公司 有塑料涂层的阀转子及具有这种阀转子的旋转阀
CN1111660C (zh) * 1997-08-26 2003-06-18 埃科沃特系统公司 有塑料涂层的阀转子和制造方法
AU746652B2 (en) * 1998-01-30 2002-05-02 Abbott Laboratories Method for making a stopper
US20020048669A1 (en) * 1999-01-29 2002-04-25 Masamichi Sudo Molding die assembly for rubber members and rubber member produced thereby
US7426998B2 (en) * 1999-01-29 2008-09-23 Daikyo Seiko, Ltd. Molding die assembly for rubber members and rubber member produced thereby
US6558628B1 (en) * 1999-03-05 2003-05-06 Specialty Silicone Products, Inc. Compartment cover, kit and method for forming the same
US20020187077A1 (en) * 2000-02-02 2002-12-12 Soltec, Inc. Flexible septa closure plug mats for well plate mounted arrays of sample vials
US6939513B2 (en) * 2000-02-02 2005-09-06 Soltec, Inc. Flexible septa closure plug mats for well plate mounted arrays of sample vials
US20020113033A1 (en) * 2000-04-06 2002-08-22 Claessens Albert Louis Victor Jozef Moulding suitable for pharmaceutical applications and method for production thereof
US20050263478A1 (en) * 2000-12-04 2005-12-01 Jms Co., Ltd. Plug body for medical fluid container
US20040035816A1 (en) * 2000-12-04 2004-02-26 Tadashi Okiyama Plug body for medical fluid container
US6918500B2 (en) * 2000-12-04 2005-07-19 Jms Co., Ltd. Plug body for medical fluid container
US7163114B2 (en) 2000-12-04 2007-01-16 Jms Co., Ltd. Plug body for medical fluid container
US8573424B2 (en) * 2001-12-10 2013-11-05 Alcoa Deutschland Gmbh Container, particularly a beverage bottle
US20050167390A1 (en) * 2001-12-10 2005-08-04 Hans-Dieter Dubs Container, particularly a beverage bottle
US8356722B2 (en) * 2001-12-10 2013-01-22 Alcoa Deutschland Gmbh Container, particularly a beverage bottle
US20100252524A1 (en) * 2001-12-10 2010-10-07 Hans-Dieter Dubs Container, particularly a beverage bottle
US6874647B2 (en) * 2002-08-12 2005-04-05 Owens-Illinois Closure Inc. Plastic closure, closure and container package, and method of manufacture
US20040108294A1 (en) * 2002-08-12 2004-06-10 Bloom Kenneth S. Plastic closure, closure and container package, and method of manufacture
US7611026B1 (en) 2002-08-12 2009-11-03 Rexam Closure Systems Inc. Tamper-evident closure having a sealing disk and package for high-temperature applications
US20060151424A1 (en) * 2002-08-30 2006-07-13 Takiko Nakada Plug for container and method of producing the same
US7886923B2 (en) * 2002-08-30 2011-02-15 Suntory Holdings Limited Container stopper with synthetic resin skin
EP1457429A2 (de) 2003-03-14 2004-09-15 Helvoet Pharma Belgium N.V. Für pharmazeutische Verwendung dienende Überkappe mit Verschlussstopfen
US20060203048A1 (en) * 2005-03-14 2006-09-14 Scheffelin Joseph E Plug
US20110226722A1 (en) * 2007-03-22 2011-09-22 Epoli - Espumas De Polietileno Sa Synthetic closure with multiple internal layers, each layer having a variable cross section (vcs) along the closure length
US8011522B2 (en) * 2007-03-22 2011-09-06 EPOLI—Espumas de polietileno SA Synthetic closure with multiple internal layers, each layer having a variable cross section (VCS) along the closure length
US20080229569A1 (en) * 2007-03-22 2008-09-25 Epoli - Espumas De Polietileno Sa Synthetic closure with multiple internal layers, each layer having a variable cross section (VCS) along the closure length
US20100206836A1 (en) * 2007-10-18 2010-08-19 Tsuyoshi Koshidaka Vial rubber-stopper
US20100264139A1 (en) * 2007-12-26 2010-10-21 Daikyo Seiko, Ltd. Molded rubber article
US8579142B2 (en) 2008-01-15 2013-11-12 Anheuser-Busch Inbev S.A. Assembly of a container and a closure
US20110024429A1 (en) * 2008-01-15 2011-02-03 Anheuser Busch Inbev S.A. Assembly of a container and a closure
US20110024422A1 (en) * 2008-01-15 2011-02-03 Anheuser Busch Inbev S.A. Closure
US20110024438A1 (en) * 2008-01-15 2011-02-03 Anheuser Busch Inbev S.A. Assembly of a container and a closure
US8727151B2 (en) 2008-01-15 2014-05-20 Anheuser-Busch Inbev S.A. Assembly of a container and a closure
US10543963B2 (en) * 2008-01-15 2020-01-28 Anheuser-Busch Inbev S.A. Closure comprising a pierceable part and container provided with such closure
US8418870B2 (en) * 2008-02-10 2013-04-16 Xubin Song Cover for preservation container
US20090223986A1 (en) * 2008-02-10 2009-09-10 Xubin Song Preservation container cover
US11944434B2 (en) 2008-03-05 2024-04-02 Becton, Dickinson And Company Capillary action collection device and container assembly
US20140318282A1 (en) * 2008-03-05 2014-10-30 Becton, Dickinson And Company Co-Molded Pierceable Stopper and Method for Making the Same
US20090308184A1 (en) * 2008-03-05 2009-12-17 Becton, Dickinson And Company Co-Molded Pierceable Stopper and Method for Making the Same
US8806920B2 (en) 2008-03-05 2014-08-19 Becton, Dickinson And Company Co-molded pierceable stopper and method for making the same
US9260795B2 (en) 2009-03-09 2016-02-16 Japan Super Quartz Corporation Closure for silica glass crucible, silica glass crucible and method of handling the same
US20100226747A1 (en) * 2009-03-09 2010-09-09 Japan Super Quartz Corporation Closure for silica glass crucible, silica glass crucible and method of handling the same
EP2250992A1 (de) * 2009-05-13 2010-11-17 Hubei Huaqiang High-Tech Co., Ltd. Teilweise mit PET-Folie beschichteter Gummistopfen und dessen Herstellungsverfahren
US20110001269A1 (en) * 2009-07-01 2011-01-06 Murena Denis Device for producing pin-shaped end products by the injection-molding process
US8313685B2 (en) 2009-07-01 2012-11-20 Lonstroff Ag Device for producing pin-shaped end products by the injection-molding process
US20110061795A1 (en) * 2009-09-16 2011-03-17 Lonstroff Ag Method for producing a stopper
US8460620B2 (en) 2010-12-03 2013-06-11 Becton, Dickinson And Company Specimen collection container assembly
US9399218B2 (en) 2010-12-03 2016-07-26 Becton, Dickinson And Company Specimen collection container assembly
US9962704B2 (en) 2010-12-03 2018-05-08 Becton, Dickinson And Company Specimen collection container assembly
CN106742628A (zh) * 2017-01-09 2017-05-31 成都迅德科技有限公司 一种医用胶塞

Also Published As

Publication number Publication date
JPS549119B1 (de) 1979-04-21
DE2146421A1 (de) 1972-04-13
CH531347A (de) 1972-12-15
GB1342975A (en) 1974-01-10
FR2106567A1 (de) 1972-05-05
NL7112762A (de) 1972-03-20
FR2106567B1 (de) 1974-08-19
IT942607B (it) 1973-04-02

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