US3740041A - Reagent mixing apparatus - Google Patents

Reagent mixing apparatus Download PDF

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Publication number
US3740041A
US3740041A US00189311A US3740041DA US3740041A US 3740041 A US3740041 A US 3740041A US 00189311 A US00189311 A US 00189311A US 3740041D A US3740041D A US 3740041DA US 3740041 A US3740041 A US 3740041A
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US
United States
Prior art keywords
cylinder
probe
piston
port
air
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US00189311A
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English (en)
Inventor
A Jones
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Coulter Chemistry Inc
Original Assignee
Coulter Chemistry Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coulter Chemistry Inc filed Critical Coulter Chemistry Inc
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Publication of US3740041A publication Critical patent/US3740041A/en
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/40—Mixers using gas or liquid agitation, e.g. with air supply tubes
    • B01F33/405—Mixers using gas or liquid agitation, e.g. with air supply tubes in receptacles having guiding conduits therein, e.g. for feeding the gas to the bottom of the receptacle

Definitions

  • the device in- R, 425 2 425 25 92/15 91/52 cludes a cylinder having a piston connected with an air 450, 449, 466, 462; 141/181, 129, 222/3, injecting probe adapted to be lowered into the reaction 143 5; 5 R tube and to inject bubbles and thereafter to be retractedinto the cylinder while at the same time wiping 5
  • the problems involved include not disturbing the position of the tubes by raising or rocking or agitating the same so that the transport apparatus can be of simple construction, avoiding a complex air injection apparatus for efficacy and economy and preventing the intercontamination between the sample solutions in the respective reaction tubes.
  • the apparatus of the invention has a cylindrical member with a reciprocable piston on its interior.
  • the upper end of the cylinder has a port above the piston and the lower end of the cylinder is also ported below the piston.
  • a hollow probe is connected to the bottom of the piston and a central constricted passageway permits the probe to be extended from and retracted into the cylinder.
  • the constricted passageway is of a diameter slightly larger than the outer diameter of the probe so that air may escape around the probe in a curtain under certain circumstances.
  • the interior of the cylinder has a gallery connected with the lower port below the piston and through which the probe extends and in addition connected with the constricted passageway.
  • Air applied under pressure to the top port will drive the piston downwardly to cause the probe to extend into a reaction tube and at the same time eject bubbles of air. Thereafter, air admitted to the bottom port will pass into the gallery, raise the piston and retract the probe while at the same time forcing a curtain of air out the restricted passageway and thereby wiping the probe while it is being retracted.
  • Magnetic means hold the piston in its upper position with the probe retracted.
  • FIG. 1 is a median sectional view through apparatus constructed in accordance with the invention showing the environment in which it will be used and showing diagrammatically apparatus for operating the same;
  • FIG. 2 is a chart used to explain the operation of the apparatus of FIG. 1.
  • the reference character designates the apparatus of the invention, the same being mounted in the disposition shown to some suitable support (not shown) spaced above a line of reaction tubes 12 moving along a conveyor 14.
  • Each tube has a sample solution 16 therein which is to be mixed without disturbing the tubes 12 or interfering with their movement.
  • Each tube is adapted to be stopped in its travel for a short time under the apparatus 10 and have its sample solution mixed thereat.
  • the apparatus 10 comprises a cylinder 18 having a closure 20 at its upper end providing a port 21 connected by the conduit 22 at the point A to a pneumatic line leading to a suitable valve 24.
  • the valve 24 enables the conduit 22 to be connected to a source of pressure 26 or to be closed off.
  • the lower end of the cylinder 18 has a lateral port 30 connected by the conduit 32 at the point B to a pneumatic line leading to the valve 24 and capable of being vented as at 34 or connected to the source of pressure 26.
  • the cylinder has a free piston 36 reciprocable therewithin, and a central hollow probe 38 connects with the piston 36 in such a manner that its upper end 40 opens above the piston.
  • the lower end or tip 44 of the hollow probe 38 may extend out of the cylinder 18 by way of the conical plug 42 as shown in the drawing, or may be retracted! when the piston 36 moves upward, at which latter time the tip 44 will be located at the point 46 shown in broken lines.
  • the port 30 opens into a gallery 48 formed in the plug 42 and connecting with an axial passageway 50 slightly larger in diameter than the outer diameter of the probe 38.
  • the upper end of the piston 36 carries a magnetic disc 52 adapted to cooperate with the lower surface of the closure 20 magnetically so that at the upper end of the piston stroke, the piston 36 will tend to remain adhered to the plug 20 .as shown by the broken line outline at 36.
  • the material of plug 20 and disc 52 may be any suitable substance which can be permanently magnetized such as rubber with iron powder mixed therein.
  • step 1 Air pressure is applied to the port 21 and the port 30 is vented to the atmosphere. Air entering the upper end of the cylinder 18 forces the piston 36 to leave its magnetic adherence to plug 20 and drives the piston 36 downwardly extending the probe 33 into the sample solution 16 of the tube 12. Continued application of pressure causes bubblesshown at 56 to pass out the end 44 which may be suitably restricted by a choke 58 to achieve the desired size of bubbles. After a short period of time, at which the step 2 occurs, with the connection to port 30 being either closed or vented, step 3 occurs.
  • step 3 the valve 24 is operated to close conduit 22 so that the port 21 is closed and the conduit 32 is connected to pressure source 26 so that pressure is applied to the port30.
  • Air entering the gallery 48 exerts pressure against the bottom of the piston 36 raising it and starting to retract the probe 38 from the sample solution 16. Since the port 21 is closed, air captured within the cylinder will escape to the opening 40 and pass down the interior of the probe 38 to clear its interior and bubble out of the solution while the probe is moving. Also, air passes down from the gallery 48 through the passageway 50 surrounding the exterior of the probe 38 with a curtain of air at high pressure and blowing the moisture off the surface of the probe so that when it is fully retracted it is dry. At this time, the piston 36 is in position 36 poised for the next cycle. This is step 4 with both parts vented.
  • the ability to retract the probe 38 enables the bottom end of the plug 42 to be positioned closely to the upper ends of the passing reaction tubes 12. Space is conserved thereby.
  • the probe 38 is preferably made of soft plastic so that it is light in weight and so that any failure of synchronization of its operation with the movement of the conveyor 14 will not result in jamming or breakage.
  • the valve 24 may comprise a plurality of valves to accomplish the desired connections.
  • a reagent mixing apparatus comprising:
  • D. means closing off the bottom end of the cylinder but having a central axially extending passageway through which the probe may be extended from and retracted into the cylinder,
  • E a chamber formed within the cylinder below the piston at the bottom end of its stroke, connected with the lower port and being constructed and arranged to divide any air introduced through said lower port to raise the piston and retract the probe while at the same time blowing air through the central passageway around the periphery of the probe while it is being retracted,
  • the upper port adapted to be connected to a source of air pressure so that when such air pressure is applied thereto the piston will be driven downwardly and extend the probe out of the bottom end of the cylinder while at the same time air will be passed through the probe and out the bottom end thereof, and
  • G means for retaining the piston at the upper end of its stroke when no air is being introduced to the upper port.
  • closing off means comprise a plug in the bottom end of the cylinder and the chamber and axially extending passageway are formed in the plug.
  • the chamber comprises a gallery coaxial with the passageway and having a diameter greater than said passageway, the lower end of the chamber being connected with said passageway so that the probe extends through the center of the gallery while the upper end of the gallery opens to the bottom of the piston.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
US00189311A 1971-10-14 1971-10-14 Reagent mixing apparatus Expired - Lifetime US3740041A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18931171A 1971-10-14 1971-10-14

Publications (1)

Publication Number Publication Date
US3740041A true US3740041A (en) 1973-06-19

Family

ID=22696776

Family Applications (1)

Application Number Title Priority Date Filing Date
US00189311A Expired - Lifetime US3740041A (en) 1971-10-14 1971-10-14 Reagent mixing apparatus

Country Status (13)

Country Link
US (1) US3740041A (enrdf_load_stackoverflow)
JP (1) JPS5129958B2 (enrdf_load_stackoverflow)
AU (1) AU452722B2 (enrdf_load_stackoverflow)
CA (1) CA964645A (enrdf_load_stackoverflow)
CH (1) CH571886A5 (enrdf_load_stackoverflow)
DE (1) DE2249594B2 (enrdf_load_stackoverflow)
ES (1) ES407497A1 (enrdf_load_stackoverflow)
FR (1) FR2156204B1 (enrdf_load_stackoverflow)
GB (1) GB1395080A (enrdf_load_stackoverflow)
IL (1) IL40529A (enrdf_load_stackoverflow)
IT (1) IT966274B (enrdf_load_stackoverflow)
NL (1) NL7213660A (enrdf_load_stackoverflow)
ZA (1) ZA727240B (enrdf_load_stackoverflow)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3869068A (en) * 1974-06-06 1975-03-04 Hyperion Inc Diluter probe assembly
US4139585A (en) * 1976-07-21 1979-02-13 Wacker-Chemie Gmbh Valve for the introduction of gas
US4325495A (en) * 1979-07-16 1982-04-20 Pulsonics Corporation Storage bin activator device and method for restoring bulk material free flow
US4461404A (en) * 1982-05-24 1984-07-24 Eastman Kodak Company Apparatus for moving an adhesive applicator
US4489856A (en) * 1982-05-24 1984-12-25 Eastman Kodak Company Method and apparatus for moving a nozzle between a storage position and a position for applying a fluid
US4949572A (en) * 1988-11-30 1990-08-21 Computer Instruments Corporation Method and apparatus for determining physical properties of liquids
US5080868A (en) * 1990-05-16 1992-01-14 Elgas David H Sparger assembly
US5261566A (en) * 1981-02-16 1993-11-16 Tokyo Ohka Kogyo Co., Ltd. Solution-dropping nozzle device
US6325359B1 (en) * 1999-07-05 2001-12-04 Organo Corporation Device and method for producing gas solution and cleaning device
US20100028180A1 (en) * 2008-07-30 2010-02-04 Shimano Benelux B.V. Bicycle air pump
CN102854052A (zh) * 2012-08-08 2013-01-02 长春迪瑞医疗科技股份有限公司 一种气泡混匀方法及其控制系统
CN107597000A (zh) * 2017-10-30 2018-01-19 哈尔滨纳诺机械设备有限公司 一种气流混合器

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60166370U (ja) * 1984-04-13 1985-11-05 マルマンゴルフ株式会社 ゴルフ用パタ−
JPH0720980B2 (ja) * 1991-11-26 1995-03-08 株式会社島津製作所 ペプチド合成装置

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2893354A (en) * 1955-09-27 1959-07-07 Bendix Aviat Corp Fluid pressure motor
US2975119A (en) * 1958-12-05 1961-03-14 Clarence D Emmons Vertical rod drive mechanism
US3313215A (en) * 1962-02-09 1967-04-11 Bieri Hans Cylinder and piston arrangement
US3535206A (en) * 1968-08-08 1970-10-20 Atomic Energy Commission Pneumatic scram rod drive
US3536449A (en) * 1967-04-13 1970-10-27 Thomas W Astle Serial dilution machine

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2893354A (en) * 1955-09-27 1959-07-07 Bendix Aviat Corp Fluid pressure motor
US2975119A (en) * 1958-12-05 1961-03-14 Clarence D Emmons Vertical rod drive mechanism
US3313215A (en) * 1962-02-09 1967-04-11 Bieri Hans Cylinder and piston arrangement
US3536449A (en) * 1967-04-13 1970-10-27 Thomas W Astle Serial dilution machine
US3535206A (en) * 1968-08-08 1970-10-20 Atomic Energy Commission Pneumatic scram rod drive

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3869068A (en) * 1974-06-06 1975-03-04 Hyperion Inc Diluter probe assembly
US4139585A (en) * 1976-07-21 1979-02-13 Wacker-Chemie Gmbh Valve for the introduction of gas
US4325495A (en) * 1979-07-16 1982-04-20 Pulsonics Corporation Storage bin activator device and method for restoring bulk material free flow
US5261566A (en) * 1981-02-16 1993-11-16 Tokyo Ohka Kogyo Co., Ltd. Solution-dropping nozzle device
US4461404A (en) * 1982-05-24 1984-07-24 Eastman Kodak Company Apparatus for moving an adhesive applicator
US4489856A (en) * 1982-05-24 1984-12-25 Eastman Kodak Company Method and apparatus for moving a nozzle between a storage position and a position for applying a fluid
US4949572A (en) * 1988-11-30 1990-08-21 Computer Instruments Corporation Method and apparatus for determining physical properties of liquids
US5080868A (en) * 1990-05-16 1992-01-14 Elgas David H Sparger assembly
US6325359B1 (en) * 1999-07-05 2001-12-04 Organo Corporation Device and method for producing gas solution and cleaning device
US20100028180A1 (en) * 2008-07-30 2010-02-04 Shimano Benelux B.V. Bicycle air pump
DE102009007627B4 (de) * 2008-07-30 2013-06-13 Shimano Benelux B.V. Fahrradluftpumpe
US9057364B2 (en) * 2008-07-30 2015-06-16 Shimano Benelux B.V. Bicycle air pump
CN102854052A (zh) * 2012-08-08 2013-01-02 长春迪瑞医疗科技股份有限公司 一种气泡混匀方法及其控制系统
CN102854052B (zh) * 2012-08-08 2015-01-07 长春迪瑞医疗科技股份有限公司 一种气泡混匀方法及其控制系统
CN107597000A (zh) * 2017-10-30 2018-01-19 哈尔滨纳诺机械设备有限公司 一种气流混合器
CN107597000B (zh) * 2017-10-30 2024-02-20 哈尔滨纳诺机械设备有限公司 一种气流混合器

Also Published As

Publication number Publication date
IL40529A0 (en) 1972-12-29
DE2249594A1 (de) 1973-04-19
AU4759872A (en) 1974-04-26
ES407497A1 (es) 1976-02-16
CA964645A (en) 1975-03-18
JPS5129958B2 (enrdf_load_stackoverflow) 1976-08-28
DE2249594B2 (de) 1976-04-08
AU452722B2 (en) 1974-09-12
ZA727240B (en) 1974-05-29
IT966274B (it) 1974-02-11
NL7213660A (enrdf_load_stackoverflow) 1973-04-17
IL40529A (en) 1974-10-22
FR2156204A1 (enrdf_load_stackoverflow) 1973-05-25
FR2156204B1 (enrdf_load_stackoverflow) 1977-08-26
JPS4847892A (enrdf_load_stackoverflow) 1973-07-06
GB1395080A (en) 1975-05-21
CH571886A5 (enrdf_load_stackoverflow) 1976-01-30

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