US3694547A - Anti-dandruff hair preparation - Google Patents
Anti-dandruff hair preparation Download PDFInfo
- Publication number
- US3694547A US3694547A US196226A US3694547DA US3694547A US 3694547 A US3694547 A US 3694547A US 196226 A US196226 A US 196226A US 3694547D A US3694547D A US 3694547DA US 3694547 A US3694547 A US 3694547A
- Authority
- US
- United States
- Prior art keywords
- rennet
- hair
- hair preparation
- dandruff
- lotion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003676 hair preparation Substances 0.000 title claims abstract description 29
- 208000001840 Dandruff Diseases 0.000 title abstract description 15
- 229940108461 rennet Drugs 0.000 claims abstract description 24
- 108010058314 rennet Proteins 0.000 claims abstract description 24
- 239000006210 lotion Substances 0.000 claims abstract description 18
- 230000001476 alcoholic effect Effects 0.000 claims abstract description 8
- 239000002453 shampoo Substances 0.000 claims abstract description 6
- 239000000839 emulsion Substances 0.000 claims abstract description 5
- 230000000694 effects Effects 0.000 abstract description 7
- 239000003795 chemical substances by application Substances 0.000 abstract description 5
- 239000006071 cream Substances 0.000 abstract description 5
- 108091005804 Peptidases Proteins 0.000 abstract description 4
- 102000035195 Peptidases Human genes 0.000 abstract description 4
- 239000000499 gel Substances 0.000 abstract description 3
- 239000000463 material Substances 0.000 abstract description 2
- 239000007921 spray Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 239000002304 perfume Substances 0.000 description 6
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 4
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- FYUWIEKAVLOHSE-UHFFFAOYSA-N ethenyl acetate;1-ethenylpyrrolidin-2-one Chemical compound CC(=O)OC=C.C=CN1CCCC1=O FYUWIEKAVLOHSE-UHFFFAOYSA-N 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 2
- 229920000151 polyglycol Polymers 0.000 description 2
- 239000010695 polyglycol Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 2
- 229960004889 salicylic acid Drugs 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 108090000746 Chymosin Proteins 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- FPVVYTCTZKCSOJ-UHFFFAOYSA-N Ethylene glycol distearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCOC(=O)CCCCCCCCCCCCCCCCC FPVVYTCTZKCSOJ-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- 102000004882 Lipase Human genes 0.000 description 1
- 108090001060 Lipase Proteins 0.000 description 1
- 239000004367 Lipase Substances 0.000 description 1
- 108010019160 Pancreatin Proteins 0.000 description 1
- 239000005662 Paraffin oil Substances 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 239000007859 condensation product Substances 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000002951 depilatory effect Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000010794 food waste Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- VGWSECAZSRHNCT-UHFFFAOYSA-N hexadecyl octadecyl sulfate Chemical compound CCCCCCCCCCCCCCCCCCOS(=O)(=O)OCCCCCCCCCCCCCCCC VGWSECAZSRHNCT-UHFFFAOYSA-N 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 108010059345 keratinase Proteins 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 235000019421 lipase Nutrition 0.000 description 1
- 229940105132 myristate Drugs 0.000 description 1
- 229940055695 pancreatin Drugs 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000012177 spermaceti Substances 0.000 description 1
- 229940084106 spermaceti Drugs 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- TUNFSRHWOTWDNC-UHFFFAOYSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/006—Antidandruff preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/04—Dandruff
Definitions
- This invention relates to hair preparations containing rennet and particularly to lotions containing rennet for the control of dandruff.
- trypsin should be added to dental preparations in order to dissolve protein-containing food residues.
- Proteolytic enzymes such as keratinase have also been suggested for use as depilatories.
- Tryptic enzymes such as pancreatin
- hair preparations which are generally acidic
- lipases mixtures of proteolytic enzymes
- the present invention provides a hair preparation having activity against dandruff comprising, as an antidandruff agent from about 0.02 to about 1 percent by weight of rennet.
- hair lotions containing rennet are effective in controlling dandruff.
- Rennet is a substance normally used in cheese-making (and which is therefore commercially available) which contains the enzyme chymosin. It is usually prepared microbiologically; or alternatively it can be isolated from natural sources such as calves stomachs.
- the'amount of rennet required to give an acceptable antidandruff effect in the composition of the invention is from 0.0l to 1 percent, preferably 0.01 to 0.5 percent by weight.
- the most suitable form of hair preparation according to the invention is a lotion, that is an aqueous, alcoholic or aqueous/alcoholic solution or emulsion containing rennet, although'other forms, for example shampoos, gels and creams are not excluded.
- the pH of the preparation will be from 2 to 9, most preferably from 4.5 to 7.
- a particularly preferred mode of obtaining a composition within the pH range is to formulate it to include a buffer so that it is buffered at from about pH 5-6. r
- EXAMPLE 1 This is an example of an alcoholic hair lotion by weight Rennet l :220,000) 0.05
- Water balance EXAMPLEZ This is an example of an aqueous hair lotion I: by weight Rennet l:220,000) 0.05 Sodium benzoate 0. l 5 Perfume 0.2
- Water balance EXAMPLE 3 This is an example of an aqueous/alcoholic hair setting preparation by weight Luviskol VA64 2.0 Rennet l:l00,000) 0.1 lsopropanol 45.0 Perfume 0.4
- Water balance Luviskol VA64 (Trade Mark) is a commercially available polyvinylpyrrolidone/vinyl acetate copolymer.
- EXAMPLE 4 This is an example of a hair preparation in the form of a gel
- Carbopol 940 (Trade Mark) is a carboxyvinyl polymer which functions as a thickening agent.
- EXAMPLE 5 This is an example of a hair cream preparation by weight Paraffin Oil 1 Lanolin Glycerine Cityl alcohol Lanette N Rennet (l:l00,00) p-l-lydroxybenzoic acid-ethyl ester Perfume Water balance Lanette N (Trade Mark) is a 9:1 mixture of cetyl stearyl alcohol/sodium cetyl stearyl sulphate.
- EXAMPLE 6 This is an example of a hair preparation in the form of a conditioner by weight Katioran (Trade Mark) is a hydrophilic fatty acid condensation product.
- EXAMPLE 7 This is an example of a hair preparation in the form of a shampoo by weight Sodium alkyl polyglycol ether sulphate l5.2 Ethylene glycol distearate l.0 Sodium chloride 2.0 Technical grade rennet powder 0.5 Perfume 0.5 Water balance The composition was adjusted to pH 5.5 with citric acid.
- EXAMPLE 8 This is an example of a hair preparation in the form of a cream lotion k by weight Stearyl alcohol 3.5 Stearyl alcohol polyglycol ether 3.5spermaceti 5.0 lsopropyl myristate 3.0 Glycerine 5.0 Technical grade rennet powder 0.1 Perfume 0.4 Water balance This composition was emulsified and found to have a pH of 6.4.
- EXAMPLE 9 The following experiment was performed to ascertain the effectiveness of a lotion of the formulation shown in Example 1 in combatting dandruff.
- a group of 100 people with bad or moderate dandruff were asked to apply the lotion twice a day and to wash their hair at the beginning of the trial period but not during it.
- a second group of 100 were asked to apply a lotion of the following formula in the same way:
- a hair preparation having activity against dandruff comprising, as an anti-dandruff agent from about 0.0] to about 1 percent by weight of rennet.
- a hair preparation according to claim 1 in the form of a lotion in the form of a lotion.
- a hair preparation according to claim 1 in the form of a shampoo in the form of a shampoo.
- a hair preparation according to claim 1 having a pH of from about 2 to about 9.
- a hair preparation according to claim 5 having a pH of from about 4.5 to about 7.
- a hair preparation according to claim 6 having a pH buffered at from about 5 to about 6.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
LU62030 | 1970-11-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
US3694547A true US3694547A (en) | 1972-09-26 |
Family
ID=19726533
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US196226A Expired - Lifetime US3694547A (en) | 1970-11-10 | 1971-11-05 | Anti-dandruff hair preparation |
Country Status (11)
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3949087A (en) * | 1971-07-06 | 1976-04-06 | Labaz | Method of suppressing seborrhea |
US5834409A (en) * | 1995-03-31 | 1998-11-10 | Colgate-Palmolive Company | Scalp care products containing anti itching/anti irritant agents |
US6375948B1 (en) * | 1999-07-12 | 2002-04-23 | Kao Corporation | Treating method for suppressing hair growth |
USRE37872E1 (en) * | 1989-02-16 | 2002-10-08 | Inhale Therapeutics Systems, Inc. | Storage of materials |
USRE38385E1 (en) * | 1989-02-16 | 2004-01-13 | Nektar Therapeutics | Storage of materials |
US20080207928A1 (en) * | 2005-03-12 | 2008-08-28 | Ranjit Bhogal | Hair and/or Scalp Care Compositions Incorporating Flavonoid Compounds |
US20080206180A1 (en) * | 2005-03-12 | 2008-08-28 | Ranjit Bhogal | Hair and/or scalp Care Compositions Incorporating Amino-Oxo-Indole-Ylidene Compounds |
US20080255082A1 (en) * | 2005-03-12 | 2008-10-16 | Ranjit Bhogal | Hair and/or Scalp Care Compositions Incorporating Terpenoid Compounds |
US7744925B2 (en) | 1994-12-02 | 2010-06-29 | Quadrant Drug Delivery Limited | Solid dose delivery vehicle and methods of making same |
US20110243876A1 (en) * | 2010-04-01 | 2011-10-06 | Rajan Keshav Panandiker | Organosilicones |
-
1970
- 1970-11-10 LU LU62030D patent/LU62030A1/xx unknown
-
1971
- 1971-10-27 DE DE2153386A patent/DE2153386C3/de not_active Expired
- 1971-11-05 FR FR7139816A patent/FR2113863B1/fr not_active Expired
- 1971-11-05 AT AT954971A patent/AT313475B/de active
- 1971-11-05 US US196226A patent/US3694547A/en not_active Expired - Lifetime
- 1971-11-05 CH CH1615471A patent/CH563772A5/xx not_active IP Right Cessation
- 1971-11-08 CA CA127,077A patent/CA958646A/en not_active Expired
- 1971-11-08 AR AR238907A patent/AR194350A1/es active
- 1971-11-09 ES ES396848A patent/ES396848A1/es not_active Expired
- 1971-11-09 BR BR007458/71A patent/BR7107458D0/pt unknown
- 1971-11-09 IT IT70668/71A patent/IT974566B/it active
Non-Patent Citations (1)
Title |
---|
Cayle, Journal of the Society of Cosmetic Chemists, Vol. 14, No. 6, page 254, June 1963 * |
Cited By (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3949087A (en) * | 1971-07-06 | 1976-04-06 | Labaz | Method of suppressing seborrhea |
USRE38385E1 (en) * | 1989-02-16 | 2004-01-13 | Nektar Therapeutics | Storage of materials |
USRE39497E1 (en) * | 1989-02-16 | 2007-02-27 | Nektar Therapeutics | Storage of materials |
USRE37872E1 (en) * | 1989-02-16 | 2002-10-08 | Inhale Therapeutics Systems, Inc. | Storage of materials |
US7780991B2 (en) | 1994-12-02 | 2010-08-24 | Quadrant Drug Delivery Limited | Solid dose delivery vehicle and methods of making same |
US7744925B2 (en) | 1994-12-02 | 2010-06-29 | Quadrant Drug Delivery Limited | Solid dose delivery vehicle and methods of making same |
US7785631B2 (en) | 1994-12-02 | 2010-08-31 | Quadrant Drug Delivery Limited | Solid dose delivery vehicle and methods of making same |
US5834409A (en) * | 1995-03-31 | 1998-11-10 | Colgate-Palmolive Company | Scalp care products containing anti itching/anti irritant agents |
US6375948B1 (en) * | 1999-07-12 | 2002-04-23 | Kao Corporation | Treating method for suppressing hair growth |
US7211278B2 (en) | 1999-07-12 | 2007-05-01 | Kao Corporation | Treating method for suppressing hair growth |
US7056499B2 (en) | 1999-07-12 | 2006-06-06 | Kao Corporation | Treating method for suppressing hair growth |
US20080207928A1 (en) * | 2005-03-12 | 2008-08-28 | Ranjit Bhogal | Hair and/or Scalp Care Compositions Incorporating Flavonoid Compounds |
US20080255082A1 (en) * | 2005-03-12 | 2008-10-16 | Ranjit Bhogal | Hair and/or Scalp Care Compositions Incorporating Terpenoid Compounds |
US20080206180A1 (en) * | 2005-03-12 | 2008-08-28 | Ranjit Bhogal | Hair and/or scalp Care Compositions Incorporating Amino-Oxo-Indole-Ylidene Compounds |
US7807707B2 (en) * | 2005-03-12 | 2010-10-05 | Conopco Inc. | Hair and/or scalp care compositions incorporating amino-oxo-indole-ylidene compounds |
US20110243876A1 (en) * | 2010-04-01 | 2011-10-06 | Rajan Keshav Panandiker | Organosilicones |
US9212338B2 (en) | 2010-04-01 | 2015-12-15 | The Procter & Gamble Company | Organosilicones |
US9650593B2 (en) | 2010-04-01 | 2017-05-16 | The Procter & Gamble Company | Organosilicones |
Also Published As
Publication number | Publication date |
---|---|
AT313475B (de) | 1974-02-25 |
FR2113863B1 (enrdf_load_stackoverflow) | 1975-08-29 |
DE2153386A1 (de) | 1972-05-18 |
CH563772A5 (enrdf_load_stackoverflow) | 1975-07-15 |
DE2153386C3 (de) | 1978-04-13 |
BR7107458D0 (pt) | 1973-08-16 |
FR2113863A1 (enrdf_load_stackoverflow) | 1972-06-30 |
AR194350A1 (es) | 1973-07-13 |
IT974566B (it) | 1974-07-10 |
DE2153386B2 (de) | 1977-08-25 |
LU62030A1 (enrdf_load_stackoverflow) | 1972-07-26 |
ES396848A1 (es) | 1975-04-01 |
CA958646A (en) | 1974-12-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: CPPD, INC., A CORP. OF IL, ILLINOIS Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:LEVER BROTHERS COMPANY, A CORP. OF ME;REEL/FRAME:004888/0628 Effective date: 19880101 Owner name: CPPD, INC., C/O CT CORPORATION SYSTEM 208 LASALLE Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:LEVER BROTHERS COMPANY, A CORP. OF ME;REEL/FRAME:004888/0628 Effective date: 19880101 |