US3692835A - Pharmacologically active amino-ethyl oximes - Google Patents
Pharmacologically active amino-ethyl oximes Download PDFInfo
- Publication number
- US3692835A US3692835A US715571A US3692835DA US3692835A US 3692835 A US3692835 A US 3692835A US 715571 A US715571 A US 715571A US 3692835D A US3692835D A US 3692835DA US 3692835 A US3692835 A US 3692835A
- Authority
- US
- United States
- Prior art keywords
- group
- mls
- ethyl
- ether
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
- C07D327/06—Six-membered rings
- C07D327/08—[b,e]-condensed with two six-membered carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/18—Fluorenes; Hydrogenated fluorenes
Definitions
- the temperature of the reaction mixture may vary between rather wide limits. As a rule, however, it will be between 0 and 50 C.
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL676704810A NL150105B (nl) | 1967-04-05 | 1967-04-05 | Verbindingen met antidepressieve werking. |
NL676717001A NL151361B (nl) | 1967-12-14 | 1967-12-14 | Verbindingen met centrale werking. |
Publications (1)
Publication Number | Publication Date |
---|---|
US3692835A true US3692835A (en) | 1972-09-19 |
Family
ID=26644178
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US715571A Expired - Lifetime US3692835A (en) | 1967-04-05 | 1968-03-25 | Pharmacologically active amino-ethyl oximes |
US06/814,019 Expired - Fee Related US5008452A (en) | 1967-04-05 | 1989-12-20 | Aminoethyl oximes |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US06/814,019 Expired - Fee Related US5008452A (en) | 1967-04-05 | 1989-12-20 | Aminoethyl oximes |
Country Status (16)
Country | Link |
---|---|
US (2) | US3692835A (de) |
AT (4) | AT289760B (de) |
BE (1) | BE713172A (de) |
CA (1) | CA959063A (de) |
CH (2) | CH534669A (de) |
DE (1) | DE1768100C2 (de) |
DK (1) | DK120384B (de) |
ES (2) | ES352329A1 (de) |
FI (1) | FI49957C (de) |
FR (2) | FR1583796A (de) |
GB (1) | GB1205665A (de) |
IE (1) | IE33428B1 (de) |
IL (1) | IL29740A (de) |
NO (1) | NO125974B (de) |
SE (1) | SE352078B (de) |
YU (3) | YU33857B (de) |
Cited By (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3903164A (en) * | 1972-03-24 | 1975-09-02 | Kabi Ab | Pharmacodynamically active amino alkyloxim ethers |
US4038317A (en) * | 1975-02-12 | 1977-07-26 | Seperic | O-aminoalkyl oximes |
US4060631A (en) * | 1975-03-20 | 1977-11-29 | U.S. Philips Corporation | Aminoethyl oxime ethers having anti-depressive activity |
US4062969A (en) * | 1976-06-25 | 1977-12-13 | Union Carbide Corporation | Dioxane oxime compounds and pesticidal dioxane carbamoyloxime derivatives |
US4077999A (en) * | 1976-01-27 | 1978-03-07 | Egyt Gyogyszervegyeszeti Gyar | Novel oxime ethers |
US4081552A (en) * | 1975-03-20 | 1978-03-28 | U.S. Philips Corporation | Oxime ethers having anti-depressive activity |
US4081551A (en) * | 1975-03-20 | 1978-03-28 | U.S. Philips Corporation | Oxime ethers having anti-depressive activity |
US4085225A (en) * | 1975-03-20 | 1978-04-18 | U.S. Philips Corporation | Oxime ethers having anti-depressive activity |
US4086361A (en) * | 1975-03-20 | 1978-04-25 | U.S. Philips Corporation | Aminoethyl oximes having anti-depressive activity |
FR2387945A1 (fr) * | 1977-03-02 | 1978-11-17 | Ciba Geigy Ag | Agents favorisant la croissance des plantes et phytoprotecteurs a base d'oximethers et d'oximesters |
US4192893A (en) * | 1975-03-20 | 1980-03-11 | U.S. Philips Corporation | Anti-depressive compounds |
US4242348A (en) * | 1970-06-11 | 1980-12-30 | Duphar International Research B.V. | Novel basic substituted-alkylidenamino-oxylalkyl-carboxylic-acid esters |
US4328227A (en) * | 1976-12-24 | 1982-05-04 | Hoechst Aktiengesellschaft | Novel O-propyloximes |
US4342763A (en) * | 1979-02-13 | 1982-08-03 | Provesan S.A. | P-Chloroacetophenone oxime compounds and pharmaceutical compositions |
US4358450A (en) * | 1976-12-24 | 1982-11-09 | Hoechst Aktiengesellschaft | O-Alkylated oximes and pharmaceutical composition thereof |
US4388106A (en) * | 1978-08-31 | 1983-06-14 | Ciba-Geigy Corporation | Oxime derivatives for protecting plant crops |
US4488898A (en) * | 1978-08-31 | 1984-12-18 | Ciba-Geigy Corporation | Oxime derivatives for protecting plant crops |
US4488900A (en) * | 1978-08-31 | 1984-12-18 | Ciba-Geigy Corporation | Oxime derivatives for protecting plant crops |
US4488899A (en) * | 1978-08-31 | 1984-12-18 | Ciba-Geigy Corporation | Oxime derivatives for protecting plant crops |
US4548756A (en) * | 1977-03-02 | 1985-10-22 | Ciba Geigy Corporation | Oxime ethers |
US4581060A (en) * | 1977-03-02 | 1986-04-08 | Ciba-Geigy Corporation | Compositions, which promote plant growth and protect plants, based on oxime ethers and oxime esters |
US4709095A (en) * | 1984-08-06 | 1987-11-24 | Yoshitomi Pharmaceutical Industries, Ltd. | Ortho-aminomethylphenol compounds |
US4845287A (en) * | 1986-01-16 | 1989-07-04 | Bayer Aktiengesellschaft | Hydroxybenzaldoxime O-ethers |
US5008452A (en) * | 1967-04-05 | 1991-04-16 | Duphar International Research B.V. | Aminoethyl oximes |
WO2018096376A1 (en) | 2016-11-24 | 2018-05-31 | Mta Támogatott Kutatócsoportok Irodája | Compositions for organ preservation |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1600969A (en) * | 1977-01-07 | 1981-10-21 | Acf Chemiefarma Nv | Heterocyclic compounds |
AU532700B2 (en) * | 1979-04-02 | 1983-10-13 | Sumitomo Chemical Company, Limited | Diphenylalkanoether |
FR2518090A1 (fr) * | 1981-12-11 | 1983-06-17 | Univablot | Ethers d'oximes a-b insatures, leur procede de preparation et leur utilisation comme medicament |
US5665756A (en) * | 1994-08-03 | 1997-09-09 | Hoechst Marion Roussel, Inc. | Aminoalkyloximes useful in the treatment of depression and obsessive compulsive disorders |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1733462A (en) * | 1926-09-23 | 1929-10-29 | Winthrop Chem Co Inc | New basic oxime ethers of cyclic compounds |
US3270055A (en) * | 1963-09-11 | 1966-08-30 | Engelhard Hermann | 5-aminoalkoxy ethers of 5-hydroxyimino-10, 11-dihydro-5h-dibenzo (a, d) cyclohepta (1, 4) dienes |
US3441608A (en) * | 1964-11-26 | 1969-04-29 | Bayer Ag | 5beta - n - methylamino - ethoxyimino - 5h - dibenzo - (a,d) - 10,11 - dihydrocycloheptene and non-toxic pharmaceutically acceptable salts thereof and their production |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL6503019A (de) * | 1965-03-10 | 1966-09-12 | ||
US3692835A (en) * | 1967-04-05 | 1972-09-19 | Jan Van Dijk | Pharmacologically active amino-ethyl oximes |
US4235931A (en) * | 1967-04-05 | 1980-11-25 | Duphar International Research B.V. | Compounds having pharmacological properties |
US4192818A (en) * | 1967-04-05 | 1980-03-11 | Duphar International Research B.V. | Compounds having pharmacological properties |
NL150105B (nl) * | 1967-04-05 | 1976-07-15 | Philips Nv | Verbindingen met antidepressieve werking. |
NL7503312A (nl) * | 1975-03-20 | 1976-09-22 | Philips Nv | Verbindingen met antidepressieve werking. |
-
1968
- 1968-03-25 US US715571A patent/US3692835A/en not_active Expired - Lifetime
- 1968-03-29 FR FR1583796D patent/FR1583796A/fr not_active Expired
- 1968-03-30 DE DE1768100A patent/DE1768100C2/de not_active Expired
- 1968-04-02 AT AT141270A patent/AT289760B/de not_active IP Right Cessation
- 1968-04-02 CH CH484268A patent/CH534669A/de not_active IP Right Cessation
- 1968-04-02 DK DK144068AA patent/DK120384B/da unknown
- 1968-04-02 CA CA016,478A patent/CA959063A/en not_active Expired
- 1968-04-02 IE IE381/68A patent/IE33428B1/xx unknown
- 1968-04-02 NO NO681268A patent/NO125974B/no unknown
- 1968-04-02 AT AT141170A patent/AT289759B/de not_active IP Right Cessation
- 1968-04-02 SE SE04388/68A patent/SE352078B/xx unknown
- 1968-04-02 AT AT319868A patent/AT289758B/de not_active IP Right Cessation
- 1968-04-02 CH CH1493570A patent/CH535209A/de not_active IP Right Cessation
- 1968-04-02 AT AT141370A patent/AT289761B/de not_active IP Right Cessation
- 1968-04-02 IL IL29740A patent/IL29740A/en unknown
- 1968-04-02 GB GB05735/68A patent/GB1205665A/en not_active Expired
- 1968-04-03 BE BE713172D patent/BE713172A/xx not_active IP Right Cessation
- 1968-04-03 YU YU765/68A patent/YU33857B/xx unknown
- 1968-04-04 FI FI680931A patent/FI49957C/fi active
- 1968-06-28 FR FR157096A patent/FR7901M/fr not_active Expired
-
1969
- 1969-04-03 ES ES352329A patent/ES352329A1/es not_active Expired
- 1969-05-14 ES ES367237A patent/ES367237A1/es not_active Expired
-
1973
- 1973-03-28 YU YU845/73A patent/YU33858B/xx unknown
- 1973-03-28 YU YU847/73A patent/YU33859B/xx unknown
-
1989
- 1989-12-20 US US06/814,019 patent/US5008452A/en not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1733462A (en) * | 1926-09-23 | 1929-10-29 | Winthrop Chem Co Inc | New basic oxime ethers of cyclic compounds |
US3270055A (en) * | 1963-09-11 | 1966-08-30 | Engelhard Hermann | 5-aminoalkoxy ethers of 5-hydroxyimino-10, 11-dihydro-5h-dibenzo (a, d) cyclohepta (1, 4) dienes |
US3441608A (en) * | 1964-11-26 | 1969-04-29 | Bayer Ag | 5beta - n - methylamino - ethoxyimino - 5h - dibenzo - (a,d) - 10,11 - dihydrocycloheptene and non-toxic pharmaceutically acceptable salts thereof and their production |
Non-Patent Citations (1)
Title |
---|
Chemical Abstracts, Vol. 61, 10545 10546(1964) * |
Cited By (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5008452A (en) * | 1967-04-05 | 1991-04-16 | Duphar International Research B.V. | Aminoethyl oximes |
US4242348A (en) * | 1970-06-11 | 1980-12-30 | Duphar International Research B.V. | Novel basic substituted-alkylidenamino-oxylalkyl-carboxylic-acid esters |
US4317835A (en) * | 1970-06-11 | 1982-03-02 | Duphar International Research B.V. | Novel basic substituted-alkylidenamino-oxyalkyl-carboxylic acid esters |
US3903164A (en) * | 1972-03-24 | 1975-09-02 | Kabi Ab | Pharmacodynamically active amino alkyloxim ethers |
US4038317A (en) * | 1975-02-12 | 1977-07-26 | Seperic | O-aminoalkyl oximes |
US4086361A (en) * | 1975-03-20 | 1978-04-25 | U.S. Philips Corporation | Aminoethyl oximes having anti-depressive activity |
US4081551A (en) * | 1975-03-20 | 1978-03-28 | U.S. Philips Corporation | Oxime ethers having anti-depressive activity |
US4085225A (en) * | 1975-03-20 | 1978-04-18 | U.S. Philips Corporation | Oxime ethers having anti-depressive activity |
US4192893A (en) * | 1975-03-20 | 1980-03-11 | U.S. Philips Corporation | Anti-depressive compounds |
US4081552A (en) * | 1975-03-20 | 1978-03-28 | U.S. Philips Corporation | Oxime ethers having anti-depressive activity |
US4060631A (en) * | 1975-03-20 | 1977-11-29 | U.S. Philips Corporation | Aminoethyl oxime ethers having anti-depressive activity |
US4077999A (en) * | 1976-01-27 | 1978-03-07 | Egyt Gyogyszervegyeszeti Gyar | Novel oxime ethers |
US4062969A (en) * | 1976-06-25 | 1977-12-13 | Union Carbide Corporation | Dioxane oxime compounds and pesticidal dioxane carbamoyloxime derivatives |
US4328227A (en) * | 1976-12-24 | 1982-05-04 | Hoechst Aktiengesellschaft | Novel O-propyloximes |
US4358450A (en) * | 1976-12-24 | 1982-11-09 | Hoechst Aktiengesellschaft | O-Alkylated oximes and pharmaceutical composition thereof |
US4548756A (en) * | 1977-03-02 | 1985-10-22 | Ciba Geigy Corporation | Oxime ethers |
FR2387945A1 (fr) * | 1977-03-02 | 1978-11-17 | Ciba Geigy Ag | Agents favorisant la croissance des plantes et phytoprotecteurs a base d'oximethers et d'oximesters |
US4581060A (en) * | 1977-03-02 | 1986-04-08 | Ciba-Geigy Corporation | Compositions, which promote plant growth and protect plants, based on oxime ethers and oxime esters |
US4388106A (en) * | 1978-08-31 | 1983-06-14 | Ciba-Geigy Corporation | Oxime derivatives for protecting plant crops |
US4505742A (en) * | 1978-08-31 | 1985-03-19 | Ciba-Geigy Corporation | Oxime derivatives for protecting plant crops |
US4450000A (en) * | 1978-08-31 | 1984-05-22 | Ciba-Geigy Corporation | Oxime derivatives for protecting plant crops |
US4486224A (en) * | 1978-08-31 | 1984-12-04 | Ciba-Geigy Corporation | Oxime derivatives for protecting plant crops |
US4488898A (en) * | 1978-08-31 | 1984-12-18 | Ciba-Geigy Corporation | Oxime derivatives for protecting plant crops |
US4488900A (en) * | 1978-08-31 | 1984-12-18 | Ciba-Geigy Corporation | Oxime derivatives for protecting plant crops |
US4488899A (en) * | 1978-08-31 | 1984-12-18 | Ciba-Geigy Corporation | Oxime derivatives for protecting plant crops |
US4439230A (en) * | 1978-08-31 | 1984-03-27 | Ciba-Geigy Corporation | Oxime derivatives for protecting plant crops |
US4439228A (en) * | 1978-08-31 | 1984-03-27 | Ciba-Geigy Corporation | Oxime derivatives for protecting plant crops |
US4437879A (en) | 1978-08-31 | 1984-03-20 | Ciba-Geigy Corporation | Oxime derivatives for protecting plant crops |
US4342763A (en) * | 1979-02-13 | 1982-08-03 | Provesan S.A. | P-Chloroacetophenone oxime compounds and pharmaceutical compositions |
US4709095A (en) * | 1984-08-06 | 1987-11-24 | Yoshitomi Pharmaceutical Industries, Ltd. | Ortho-aminomethylphenol compounds |
US4845287A (en) * | 1986-01-16 | 1989-07-04 | Bayer Aktiengesellschaft | Hydroxybenzaldoxime O-ethers |
WO2018096376A1 (en) | 2016-11-24 | 2018-05-31 | Mta Támogatott Kutatócsoportok Irodája | Compositions for organ preservation |
Also Published As
Publication number | Publication date |
---|---|
AT289760B (de) | 1971-05-10 |
IE33428B1 (en) | 1974-06-26 |
BE713172A (de) | 1968-10-03 |
IE33428L (en) | 1968-10-05 |
IL29740A (en) | 1971-11-29 |
FR1583796A (de) | 1969-12-05 |
AT289758B (de) | 1971-05-10 |
CH535209A (de) | 1973-03-31 |
IL29740A0 (en) | 1968-06-20 |
SE352078B (de) | 1972-12-18 |
CA959063A (en) | 1974-12-10 |
FR7901M (de) | 1970-05-11 |
CH534669A (de) | 1973-03-15 |
AT289759B (de) | 1971-05-10 |
YU33857B (en) | 1978-06-30 |
ES367237A1 (es) | 1971-06-16 |
YU75668A (en) | 1977-12-31 |
AT289761B (de) | 1971-05-10 |
GB1205665A (en) | 1970-09-16 |
DK120384B (da) | 1971-05-24 |
DE1768100A1 (de) | 1971-10-14 |
FI49957C (fi) | 1975-11-10 |
US5008452A (en) | 1991-04-16 |
YU84573A (en) | 1977-12-31 |
YU84773A (en) | 1977-12-31 |
ES352329A1 (es) | 1969-12-16 |
NO125974B (de) | 1972-12-04 |
YU33858B (en) | 1978-06-30 |
DE1768100C2 (de) | 1986-02-06 |
FI49957B (de) | 1975-07-31 |
YU33859B (en) | 1978-06-30 |
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