US3682174A - Syringe for injection of freshly mixed liquid-powder - Google Patents

Syringe for injection of freshly mixed liquid-powder Download PDF

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Publication number
US3682174A
US3682174A US864376A US3682174DA US3682174A US 3682174 A US3682174 A US 3682174A US 864376 A US864376 A US 864376A US 3682174D A US3682174D A US 3682174DA US 3682174 A US3682174 A US 3682174A
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United States
Prior art keywords
tubular member
syringe assembly
sealing
tubular
liquid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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US864376A
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English (en)
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Milton J Cohen
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Individual
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Individual
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C—APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C17/00—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces
    • B05C17/005—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces for discharging material from a reservoir or container located in or on the hand tool through an outlet orifice by pressure without using surface contacting members like pads or brushes
    • B05C17/00593—Hand tools of the syringe type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/284—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31596—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31596—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
    • A61M2005/31598—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing having multiple telescopically sliding coaxial pistons encompassing volumes for components to be mixed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/285—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
    • A61M5/286—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened upon internal pressure increase, e.g. pierced or burst
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/285—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
    • A61M5/288—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened by piercing without internal pressure increase

Definitions

  • This invention relates to a device for injection of solutions or dispersions of a solid medicant in a liquid carrier and more particularly to a hypodermic syringe adapted to contain dry solids separate and apart from the carrier liquids until, immediately prior to administration, the liquid is caused to flow into the compartment containing the solid'material for injection of they solution or mixture formed thereof.
  • the most effective means for maintaining shelf life over extended periods of time is to maintain complete separation between the liquid carrier and the solid medicant until immediately prior to use. Maintenance of solid-liquid separation until use presents other problems with respect to ejecting and administering the solution or dispersion containing the necessary concentration of ingredients and under the most sanitary conditions.
  • the usual practice is to introduce the solids into the liquid for solution or dispersion in a suitable container from which the solution or dispersion can be taken up by a syringe for injection. This procedure requires the use of at least three separate containers and their maintenance under sterile conditions, as well as accurate measurement of the ingredients.
  • FIG. 4 is a top plan view of the floating piston seal embodied in the liquid chamber.
  • FIG. 5 is a sectional view taken along the line 5--5 of With reference to the drawings, the syringe embodying the features of this invention'comprises an outer casing 1 in the form of an elongate tubular member, formed of glass, plastics or the like, having a bore 2 extending continuously therethrough from an open rearward end 3 toa forward open-ended neck portion 4.
  • the forward open end is adapted to be sealed by means of a sealing disc member 5 dimensioned to be greater than the opening at the forward end and to abut the outwardly extending annular lip 6 on the end of the neck portion.
  • the rearward end of the tubular member is formed with an outwardly extending flange 3 which serves as a finger grip.
  • the hypodermic needle 7 is mounted in a needle hub 8, in the form of a cylindrical member, having an outwardly extending flange portion 9 at its rearward end and a threaded portion 10 in the peripheral surface at It is an object of this invention to provide 'a single device in which accurately measured amounts of solid medicant and liquid carrier can be maintained in a completely separated relation; in which the measured amounts of liquid carrier and solid medicant can be brought together immediately prior to injection; and in which the freshly formed mixture can be injected, all while maintaining the ingredients in a sealed and sanitary state, without exposure to the outside atmosphere and in which the entire operation for admixture or solution and administration can be carried out with one hand.
  • FIG. 1 is a sectional elevational view of a syringe embodying the features of this invention with the elements illustrated in position prior to use;
  • Means are provided to secure the sealing disc member 5 in sealing relation onto the open end of the casing 1 and to mount the needle hub 8 for axial displacement in the direction toward and away from the casing 1 with the rearward end 11 of the needle 7 in endwise alignment with the sealing disc member 5 and forwardly thereof, when in normal retracted position, and to pierce the disc member 5 and extend into the interior of the casing 1 when in operated position.
  • Such means is illustrated as comprising a cup-shaped cap member 12 having a rearward end portion 13 which is crimped about the outwardly extending lip 6 with the sealing disc 5 thereon to position the disc in sealing relationship across the open end of the casing.
  • the body portion of the cup-shaped member having a diameter greater than the flanged portion 9, extends forwardly for a distance and then is formed with an inwardly turned portion 14 at its forward end to define an opening 15 corresponding to the cross-sectional dimension of the needle hub 8 to enable relative sliding movement therein.
  • the needle hub 8 and the supported needle 7 are continuously urged towards operated position by means of a compression spring, in the form of a coil spring 16, which surrounds the needle hub, with one end abutting the shelf 14 while the other end abuts the annular flange 9 on the rearward end of the needle hub 8.
  • the needle hub is held in its normal retracted position with the rearward end 11 of the needle 7 within the cup immediately in advance of the sealing disc 5, as by means of a needle cover 17 having a cupped rearward end portion 18 dimensioned to correspond with the cross-section of the needle hub and flanged portion 19 extending outwardly from the rearward end thereof,
  • the internal wall of the cup portion 18 is formed with a threaded portion 18 for threaded engagementwith the forward end portion 10 of the needle hub whereby the needle cover is threaded onto the threaded end of the needle hub by an amount'to bring the flanged portion 19 into engagement with the cap 12' whereby the needle hub is retained in retracted position with the rearward end of the needle adjacent the front wall of the sealing vdisc and with the compression spring 16 in stressed relation such that, when the cover is removed, the needle hub is released for axial displacement.
  • the compression coil spring 16 becomes effective to displace the needle hub in the rearward direction automatically to project the end of the needle 7 through the sealing disc 5 and into the interior of the casing 1.
  • the elements are preassembled within the cup-shaped member 12 before it is crimped onto the lip 6.
  • A'second tubular member 20 of glass, plastic or the like material is dimensioned to have an outer wall to wall dimension which is less than the inner wall to wall dimension of the tubular member 1 to enable the fonner to be telescoped through the interior of the outer tubular member 1.
  • the second tubular member is similarly formed with a passage 21 extending from the open rearward end 22 through a neck portion 23 of smaller cross-section at theforward end.
  • the forward neck end portion of the second tubular member is fitted with a rubber stopper 24 including an outer ribbed piston ring portion 25 fitted in gripping relation ward end of the passage to seal the tubular member.
  • the rearward end portion of the second tubular member is formed with an outwardly extending flanged portion 28 for use as a finger grip, as will hereinafter be described.
  • the rearward end of the passage 21 is sealed with a rubber plug 30mounted for axial displacement through the passage 21 as a piston within the cylinder defined by the second j tubular member. Means, such as a threaded stud 31, is
  • the actuator 32 is in the form of a third elongate tubular member dimensioned to have a cross-section less than the crosssection of the passage 21 through the second tubular member and formed at one end with an internally threaded female portion 33 for threaded engagement onto the threaded stud 31.
  • the rearward end of the actuator is formed with an outwardly extending flanged sealing rib 41 or sealing ribs 41 and 42 dimensioned to 7 correspond with the cross-sectional dimension of the bore of the tubular member slidably to engage the inner wall thereof in sealing. relation.
  • the sealing ribs represent a continuation of a sealing body portion 43 having a slit 44 which extends through the central portion thereof .and which is normally closed but which can be distorted to openposition to enable passage of fluid when the piston 30 is displaced forwardly to'pressurize the fluid in the tubular member.
  • the sealing member is formed of parallel, spaced sealing ribs 41 and 42 connected by a tubular section 45 of smaller dimension with a crosswise extending deformable member 43 midway between the ends of the tubular 7 v member with the slit 44 formed in the center thereof.
  • fluid 35 is'housed in sealing relationship within the second tubular member with the floating sealing member 40 in the forward end portion thereof while the dry medicant 36 is housed in sealing relationship within the first tubular member 1.
  • the loaded device can be shipped and stored for extended periods of time without deterioration of the ingredients and without exposure of the elements to non-sanitary conditions.
  • the double seal effected by the sealing member 26 and the floating member 40 operates to maintain complete separation between the two chambers whereby the dry medicant material is not exposed to the fluid or moisture of the liquid contained in the second tubular member.
  • the device In use, the device is held with the two middle fingers under the flanged member 28 of the second tubular member and the actuator 32 is pressed by the thumb to effect displacement of the' plug 30 through the cylindrical passage 21.” This operates to place the liquid 35 under pressure which first distorts the member 43 to open the slit 44 in the pistonseal to enable the liquid to flow to the resilient closure disc 26 to cause flexure sufficient to distort the disc and establish communication between the chambers 21 and 2 through the openings 27 to enable flow of fluid under pressure from the chamber 21 in the second tubular member into the chamber 2 of the first tubular member for admixture with the dry medicant 36.
  • This intermediate position is illustrated in FIG. 2.
  • the liquid takes the medicant into solution or suspension, with shaking when necessary, to provide a freshly prepared fluid system readyfor administration by injection.
  • the needle cover 17 is removed to expose the needle 7 and to free the compression Administration is made without change of devices and without exposure of the freshly prepared solution or suspension by inserting the needle into the vessel or tissue;
  • the first tubular member may be grasped with one hand with the middle fingers beneath the flanged portion 3".
  • the needle is inserted and the thumb is pressed down onto the actuator which, at the end of its travel in the second tubular member, causes displacement of the second tubular member for movement as a piston through the cylindrical passage 2 of the first tubular member thereby forcibly to displace the freshly prepared fluid system from the interior of the first tubular member through the needle and into the tissue.
  • a syringe assembly including forward and rearward hollow tubular. members wherein the rear member is adapted to betelescoped within the forward member, means at the rearward end portions of each of said members adapted to serve as finger grips, and means sealing the forward ends thereof, the forward a medicament and a carrier in the form of a liquid respectively, whereby actuation of said piston plug will force liquid axially through said rear tubular member causing the slit in said sealing ring to open thereby permitting the liquid to travel through said neck, bend the flexible disc such that the peripheral apertures are spaced forwardly from the forward face of the neck flange thereby permitting said liquid carrier to enter said forward tubular member and mix with the medicament therein, and whereby subsequent movement of the rear tubular member will cause ejection of the mixed medicament through said hollow needle.
  • a syringe assembly as claimed in claim 1 in which the flexible closure on the forward end of the rear tubular member comprises ring members of rubber-like material in sealing engagement with the outer wall of the inner tubular member and extending into sealing engagement with the inner wall of the outer tubular member.
  • a syringe assembly as claimed in claim 1 in which the sealing ring within the inner tubular member is formed of rubber-like material having circular ribs dimensioned to extend into sealing engagement with the inner walls of the inner tubular member.
  • a syringe assembly as claimed in claim 1 which in- 4 eludes flanged members extending radially outwardly from the rearward end portions of the forward and rearward tubular members for use as finger grips.
  • the forward member having means therein for mounting a hollow hypodermic needle forwardly of the seal at the forward end thereof, and mear whereby said needle may be made to penetrate said seal and commur icate with the interior of said forward tubular member, and the rear end portion of the rear tubular member having a piston plug adapted to be reciprocated within the same and having means on the rear end portion thereof for the attachment of an actuator thereto, the improvement wherein the sealing means at the forward end of the rearward tube'serves as a closure for the rearward end of the forward tube and wherein said sealing means includes a nec portion at the forward end of the rearward tubular member having a transverse dimension which is less than the remainder thereof, said neck portion having a radially directed flange at the forwar end thereof having a transverse internal dimension that is smalle than the transverse dimension of said rear tubular member and la v ing a central opening at the forward end thereof, a flexible closure member having a portion connected to the exterior ⁇ of said

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mechanical Engineering (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
US864376A 1969-10-07 1969-10-07 Syringe for injection of freshly mixed liquid-powder Expired - Lifetime US3682174A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86437669A 1969-10-07 1969-10-07

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US3682174A true US3682174A (en) 1972-08-08

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US (1) US3682174A (enrdf_load_stackoverflow)
JP (1) JPS5113954B1 (enrdf_load_stackoverflow)
BE (1) BE757195A (enrdf_load_stackoverflow)
CA (1) CA955135A (enrdf_load_stackoverflow)
CH (1) CH513655A (enrdf_load_stackoverflow)
DE (1) DE2046145A1 (enrdf_load_stackoverflow)
DK (1) DK128766B (enrdf_load_stackoverflow)
ES (1) ES384283A1 (enrdf_load_stackoverflow)
FR (1) FR2065031A5 (enrdf_load_stackoverflow)
GB (1) GB1285415A (enrdf_load_stackoverflow)
IL (1) IL35336A (enrdf_load_stackoverflow)
NL (1) NL7014499A (enrdf_load_stackoverflow)
NO (1) NO130298B (enrdf_load_stackoverflow)
SE (1) SE379637B (enrdf_load_stackoverflow)
ZA (1) ZA706371B (enrdf_load_stackoverflow)

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US3779371A (en) * 1972-03-13 1973-12-18 W Rovinski Package of separated materials to be mixed
US3831816A (en) * 1973-06-29 1974-08-27 R Pauliukonis Chemical syringe
US3870639A (en) * 1974-01-02 1975-03-11 Moore Perk Corp Filtering device
US3885710A (en) * 1973-03-20 1975-05-27 Cohen Milton Mixing dispenser with a selectively retractable seal to permit intermixing of the ingredients
US3974832A (en) * 1975-01-07 1976-08-17 Vca Corporation Interchangeable hypodermic needle assemblage
US4009716A (en) * 1976-02-17 1977-03-01 Cohen Milton J Needle-hub assembly for syringes
DE3704453A1 (de) * 1987-02-13 1988-08-25 Anita Schumacher Doppelkolbeninjektionsspritze (mit mischkanal)
US4886495A (en) * 1987-07-08 1989-12-12 Duoject Medical Systems Inc. Vial-based prefilled syringe system for one or two component medicaments
US5088996A (en) * 1984-04-16 1992-02-18 Kopfer Rudolph J Anti-aerosoling drug reconstitution device
US5125908A (en) * 1990-10-19 1992-06-30 Cohen Milton J Hypodermic syringe with protective holder
US5171219A (en) * 1989-06-08 1992-12-15 Sumitomo Pharmaceuticals Co., Ltd. Pharmaceutical preparation administrator
US5364369A (en) * 1987-07-08 1994-11-15 Reynolds David L Syringe
US5374249A (en) * 1992-09-23 1994-12-20 Habley Medical Technology Corporation Pharmaceutical mixing container with combination stopper and pump
US5630800A (en) * 1993-11-08 1997-05-20 Ferring Arzneimettel Gmbh Injection syringe for the missing and application of injection substances
US5779668A (en) * 1995-03-29 1998-07-14 Abbott Laboratories Syringe barrel for lyophilization, reconstitution and administration
US5876372A (en) * 1995-03-22 1999-03-02 Abbott Laboratories Syringe system accomodating seperate prefilled barrels for two constituents
US20030026849A1 (en) * 1997-10-15 2003-02-06 Thomas Jefferson University Nitric oxide donor compositions, methods, apparatus, and kits for preventing or alleviating vasoconstriction or vasospasm in a mammal
US6630167B2 (en) 1999-07-28 2003-10-07 United States Surgical Corporation Hyaluronic acid anti-adhesion barrier
US20060054636A1 (en) * 2004-09-10 2006-03-16 Brennan Robert C Dual fluid cartridge for storing and dispensing fluids in unequal ratios
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US10307337B2 (en) 2015-03-24 2019-06-04 Neomed, Inc. Oral administration coupler for back-of-mouth delivery
US10369228B2 (en) 2009-03-26 2019-08-06 Jeffrey E. Thomas Method and composition for alleviating or preventing ischemic tissue damage
US10420709B2 (en) 2015-07-14 2019-09-24 Neomed, Inc. Dosing control coupling for enteral fluid transfer
US10682287B2 (en) 2015-07-14 2020-06-16 Neomed, Inc. Dosing control coupling for enteral fluid transfer and enteral couplings and syringes
US10850037B2 (en) 2013-03-22 2020-12-01 Amgen Inc. Injector and method of assembly
CN113242743A (zh) * 2018-12-19 2021-08-10 赛诺菲 用于注射装置的塑料初级包装
US11097055B2 (en) 2013-10-24 2021-08-24 Amgen Inc. Injector and method of assembly
WO2021174143A1 (en) 2020-02-26 2021-09-02 Solution Medical, Llc Drug injection apparatus, systems and methods
US20230017580A1 (en) * 2018-10-25 2023-01-19 Heraeus Medical Gmbh Device for providing bone cement
WO2024226981A1 (en) * 2023-04-27 2024-10-31 Clearstream Technologies Limited Mixing syringe assemblies and methods

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Also Published As

Publication number Publication date
GB1285415A (en) 1972-08-16
CH513655A (de) 1971-10-15
DK128766B (da) 1974-07-01
SE379637B (enrdf_load_stackoverflow) 1975-10-20
IL35336A (en) 1973-08-29
CA955135A (en) 1974-09-24
FR2065031A5 (enrdf_load_stackoverflow) 1971-07-23
NL7014499A (enrdf_load_stackoverflow) 1971-04-13
DE2046145A1 (de) 1971-04-15
BE757195A (fr) 1971-03-16
ZA706371B (en) 1971-06-30
IL35336A0 (en) 1970-11-30
ES384283A1 (es) 1973-02-16
NO130298B (enrdf_load_stackoverflow) 1974-08-12
JPS5113954B1 (enrdf_load_stackoverflow) 1976-05-06

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