US3640437A - Package for ampoules containing lyophilized products - Google Patents

Package for ampoules containing lyophilized products Download PDF

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Publication number
US3640437A
US3640437A US888370A US3640437DA US3640437A US 3640437 A US3640437 A US 3640437A US 888370 A US888370 A US 888370A US 3640437D A US3640437D A US 3640437DA US 3640437 A US3640437 A US 3640437A
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United States
Prior art keywords
ampul
package
ampuls
elements
orifice
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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US888370A
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English (en)
Inventor
Michel Galy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut Merieux SA
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Institut Merieux SA
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Assigned to PASTEUR MERIEUX SERUMS AND VACCINES reassignment PASTEUR MERIEUX SERUMS AND VACCINES EFFECTIVE ON 05/10/1990 IN FRANCE Assignors: INSTITUT MERIEUX
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/003—Filling medical containers such as ampoules, vials, syringes or the like
    • B65B3/006—Related operations, e.g. scoring ampoules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • A61J1/065—Rigid ampoules, e.g. glass ampoules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D85/00—Containers, packaging elements or packages, specially adapted for particular articles or materials
    • B65D85/30—Containers, packaging elements or packages, specially adapted for particular articles or materials for articles particularly sensitive to damage by shock or pressure
    • B65D85/42—Containers, packaging elements or packages, specially adapted for particular articles or materials for articles particularly sensitive to damage by shock or pressure for ampoules; for lamp bulbs; for electronic valves or tubes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
    • B67B—APPLYING CLOSURE MEMBERS TO BOTTLES JARS, OR SIMILAR CONTAINERS; OPENING CLOSED CONTAINERS
    • B67B7/00—Hand- or power-operated devices for opening closed containers
    • B67B7/92—Hand- or power-operated devices for opening closed containers by breaking, e.g. for ampoules
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03B—MANUFACTURE, SHAPING, OR SUPPLEMENTARY PROCESSES
    • C03B33/00—Severing cooled glass
    • C03B33/06—Cutting or splitting glass tubes, rods, or hollow products
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T225/00—Severing by tearing or breaking
    • Y10T225/30—Breaking or tearing apparatus
    • Y10T225/307—Combined with preliminary weakener or with nonbreaking cutter
    • Y10T225/321—Preliminary weakener
    • Y10T225/325—With means to apply moment of force to weakened work
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T225/00—Severing by tearing or breaking
    • Y10T225/30—Breaking or tearing apparatus
    • Y10T225/371—Movable breaking tool

Definitions

  • N o 888 370 Attorney-Cushman, Darby & Cushman [30] Foreign Application Priority Data [57] ABSTRACT Dec. 27 1968 France 180929 A Package for ampuls Containing lyoPhilized Products prising a box adaptable to contain a plurality of the ampuls 52 US. Cl ..225/96.5, 81/3 R, 206/65 A, and formed of at least two assemblable elements, two of which 225/ 103 each have an internal orifice for engaging an end of the ampul [51] Int. Cl. B261 3/00 over a certain length thereof so as to allow breaking of the [58] Field of Search ..225/93, 103, 96.5; 81/3 R; ampul by grasping one element in each hand.
  • the present invention relates to a new ampul intended primarily to contain lyophilized products, which has the advantage of being readily broken, and from which the plug of lyophilized product can be extracted without difficulty.
  • the present invention likewise relates to an apparatus for the manufacture of these new ampuls.
  • ampuls which have a neck at the level of which the break is made, either by a sawed line, or by prestressing of the glass at the time of manufacture of the ampul.
  • ampuls presently in use do not give entire satisfaction because the lyophilized product in the form of a plug of the same diameter as the ampul cannot be extracted through the ampul neck, which makes it necessary to dissolve it inside the ampul.
  • the objective of the present invention is the development of ampuls for lyophilized products that do not present the above-mentioned drawback.
  • the present invention relates to a new industrial product which is an ampul intended especially to contain lyophilized products, characterized in that it comprises a cylindrical glass receptacle closed at its ends, the said receptacle presenting, preferably in its midportion, a weakened zone constituted for example by a groove at its periphery, the said zone being preferably covered by a pasted sheet.
  • the said ampul before filling is a cylindrical receptacle closed at one end and open at the other, in which receptacle there is placed the quantity of solution or suspension that is to be lyophilized.
  • Receptacles thus filled are suitably subjected to lyophilization in a customary manner, to form within them a plug of the lyophilized product constituted by a rather compact mass with a diameter slightly less than the internal diameter of the receptacle and a length that is a function of the quantity of the product.
  • the open end of the receptacle is then closed in a customary manner.
  • a weakened zone obtained by hollowing a groove on the periphery of the tubular body of the receptacle. This can be done by any means, especially by use of a new apparatus that is to be described below.
  • the tubular body of the receptacle is surrounded at the level of the groove by a pasted sheet that tears at the same time as the ampul and which is intended, because of its adhesive part, to hold any small glass splinters that might be produced when the glass is broken.
  • the adhesive sheet comprises a self-sticking label that effects the function mentioned above while allowing ready identification of the product that is contained in the ampul.
  • the present invention likewise relates to a new industrial product that comprises a package that facilitates the opening of the above-described ampuls, the said package being essentially characterized in that it is constituted of two discrete pieces of size sufficient to be grasped separately between the fingers of one hand, and which each present an orifice inside of which it is possible to engage an end of the ampul of the ii I vention.
  • the two parts of the package in question of a relatively flexible material such for example as plastic or wood, because the elasticity of the device promotes a good break in the ampul of the invention.
  • the two parts or elements of the package constitute the cover of a box that contains the ampuls of the invention.
  • the user thus has at his disposal a simple and practical means for storing and opening the ampuls.
  • the present invention relates finally to a new industrial product which comprises an apparatus for making a groove on the peripheral part of a tubular body, particularly on the periphery of a cylindrical glass ampul, characterized essentially in that it comprises in combination means that allow the turning of the tubular body on its own axis at a low rate of speed without moving in the direction of its axis, and means whereby the periphery of a rotating driven abrasive disk is brought into contact with the tubular body, which remains in the same plane.
  • the abrasive disk is mounted on an oscillating member on which there is likewise mounted a lever with a roller, near the part of the abrasive disk that is to work on the tubular body, the said lever being recalled by elastic means that separate its roller from the axis of the said abrasive device and cooperating with a stop that limits its movement toward the axis of the abrasive disk when the oscillating member is moved in the direction of the tubular body.
  • FIG. 1 is a view of the ampuls of the invention stored according to a special embodiment, in perspective;
  • FIG. 2 is a view in perspective showing how the ampul can be opened by use of the two parts of the cover of the box shown in FIG. 1;
  • FIG. 3 is a view in section along III--III of the central part of the ampul of FIG. 2;
  • FIG. 4 is a view in section of a half of the cover of the box along line IVIV of FIG. 1;
  • FIG. 5 is a view in perspective of an embodiment of the apparatus which effects production of the peripheral groove on the ampuls
  • FIG. 6 is a view in section along VIVI of FIG. 5, showing the mounting of the diamond-coated bronze abrasive disk
  • FIGS. 7, 8 and 9 show schematically the operation of the feed device for the ampuls
  • FIGS. 10, 1 I and 12 show schematically the different stages of production of the peripheral groove on an ampul
  • FIG. 13 is a view in section of the drive rollers along XIII XII] of FIG. 10.
  • FIG. 1 there is shown in perspective a plurality of ampuls of the invention (designated as a whole by reference numeral 1) stored in a box 2 whose cover comprises two parts 3 and 4 which can be fixed onto the body of box 2 by sliding along grooves 5 or by perpendicular engagement with the said grooves by virtue of the elasticity of body 2 and parts 3 and 4 of the cover which are made of a semihard plastic material.
  • parts 3 and 4 which are identical present an orifice 6 at one of their ends, which orifice extends in the present case over above half their length and which, in the embodiment illustrated, presents three ribs 7 which delimit a space that corresponds substantially to the dimensions of ampul 1.
  • body 2 of the box presents in its lower part partitions-8 which allow separation of the different ampuls stored in the box.
  • the box is intended to contain six ampuls, but it is obvious that the number can be arbitrary.
  • ampul l is constituted by a cylindrical tubular body whose two ends 9 are closed in a known rounded form.
  • Ampul 1 contains a plug 10 of lyophilized product that can be of any kind, e.g., live enzymes.
  • the drawing shows groove 11 on the periphery of ampul 1 near the center thereof.
  • Said groove 11 is constituted by a light out made to a certain depth of the ampul wall, to constitute a weakened zone.
  • the drawing likewise shows how a self-adhering label 12 is placed above groove 11 all around the ampul.
  • This label is preferably provided with a self-sticking substance. When the ampul is broken along groove 11 it allows retention of any glass splinters that might break off.
  • parts 3 and 4 of the cover of box 2 that are held in each hand are placed on the two ends of the ampul, and using parts 3 and 4 a couple (represented in the FIG. 2 by arrows) is exerted on the ampul, which results in a clean break at the level of groove 11.
  • ampul can be opened without use of the box cover, simply by taking the ends of the ampul in either hand.
  • pieces 3 and 4 present ribs 7 which delimit orifices 6. These ribs offer the advantage of holding an ampul with a certain elasticity, but it is clear that they are not indispensable to the invention.
  • FIGS. 6 to 13 an apparatus for making groove 11 on ampul l is shown.
  • the apparatus comprises two fixed racks whose V notches are intended to receive the ampuls, which are held in position because their ends are guided by fixed plates 21 on both sides of racks 20.
  • a movable rack 22 which effects a step by step drive of the ampuls, moving them from one notch to another.
  • Movable rack 22 is driven in a circular movement by an arrangement whereby it is articulated at one end, at 23, to a pin 24 which turns about a fixed pin 25. At the other end, the movable rack is articulated at 26 to a plate 27 which is driven in rotation by a motor 28, via a reducing gear 29.
  • Two rollers 30 and 31 are mounted on either side of the fixed racks at the level of a single notch, and they are driven in rotation in the same direction by a motor 32, by a system of belts and pulleys that is schematically shown in FIG. 5.
  • an oscillating member 33 is pivoted at 34 on the frame of the apparatus.
  • the oscillating member supports an abrasive disk 35 made of diamond coated bronze, mounted between two plates 36 as shown in FIG. 6.
  • Abrasive disk 35 is driven in rotation by a motor 37 by means of a system of belts and pulleys that is schematically illustrated.
  • a swinging lever 38 pivoted also on 34, bears at one of its ends a free wheel 39 so placed as to be directly above ampul I which is on rollers 30 and 31.
  • a recall spring 40 (one of whose ends is rigidly connected to lever 38 while its other end is fixed on oscillating member 33) constantly urges wheel 39 in the direction of ampul 1, until end 41 of lever 38 is applied against an adjustable stop screw 42.
  • Another adjustable stop screw 43 allows limitation of the movement of lever 38 in the other direction, with reference to the oscillating member.
  • a recall spring 44 acts on oscillating member 33 to apply abrasive disk 35 against the tube.
  • a motor 45 which drives a disk 46 by means of a reducing gear 47 causes the oscillation of member 33 by means of a link 48 that is joined by an elongated slot 49 to a stud 50 that is fixed to the end of member 33.
  • link 48 and the size of its slot 49 are such that at each turn of plate 46 the link acts during a certain interval to lift the abrasive disk away from ampul 1, whereas during the rest of the cycle link 48 has no efi'ect on the action of the oscillating member because of slot 49.
  • the speed of motor 32 is set in such a manner that rollers 30 and 31, each provided on its periphery with a rubberized ring 51, are driven with a relatively low peripheral-speed, which may be, e.g., 25 meters per minute.
  • motor 32 continuously drives rollers 30 and 31.
  • Motors 29 and 47 function intermittently to effect the lifting of abrasive disk 35 above ampul l and to synchronize the advance of all tubes that are placed on the racks.
  • the motor 39 also permanently drives the abrasive disk at a relatively high peripheral speed, e.g., a rate of 900 meters per minute.
  • FIGS. 7 to 9 there is schematically shown the functioning of the step by step advancing device for the ampuls.
  • the successive notches of fixed rack 20 are designated A, B, C, D, and the corresponding notches of rack 22 are designated A, B, C, D.
  • notches A, B, C, D of fixed rack 20 are opposite corresponding notches A, B, C', D of movable rack 22, while the three ampuls I, II, III are placed respectively in notches B, B, C, C, and D, D of the racks.
  • movable rack 22 When movable rack 22 is driven in a movement of rotation, it begins to lift, moving toward the left, and after a quarter turn of plate 27, rack 22 has assumed the position shown in FIG. 8 in which ampuls I, II and III are lifted and moved by a distance equal to half the space that separates two notches.
  • movable rack 22 moves to the level of fixed rack 20, with correspondence of the notches, except that it is now notches B, C, D of the movable rack that correspond to notches A, B, C of the fixed rack, each of the ampuls I, II, I" having progressed by one notch toward the left.
  • the device effects a step-by-step advance of the ampuls by causing them to pass from one notch to the next.
  • FIGS. 10, ll, 12 there are shown abrasive disk 35, rollers 30 and 31 which support ampul 1, driving it in rotation, the end of lever 38 with wheel 39, and adjustable stop 43.
  • spring 40 tends permanently to urge wheel 39 toward ampul 1, it is the said wheel 39 that first comes into contact with the ampul 1, being driven in rotation thereby.
  • the groove made on the periphery of the middle part of the ampul can be made in a manner other than that which has been described.
  • the zone of weakening, at the level of which the breaking of the ampul is effected can be made by a means other than a groove without exceeding the scope of the invention.
  • said receptacle presenting, toward its middle part, a weakened zone constituted by a groove made on the periphery of the ampul, said package having the form of a box containing a plurality of ampuls and formed of at least two assemblable elements, two of the said elements each presenting an orifice inside of which it is possible to engage an end of the ampul over a certain part of its length to allow the breaking of an ampul by grasping one element in each hand.

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  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials Engineering (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Packaging Frangible Articles (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Details Of Rigid Or Semi-Rigid Containers (AREA)
US888370A 1968-12-27 1969-12-29 Package for ampoules containing lyophilized products Expired - Lifetime US3640437A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR180929 1968-12-27

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US (1) US3640437A (de)
BE (1) BE743729A (de)
DE (1) DE1964856C3 (de)
FR (1) FR1600977A (de)
LU (1) LU60080A1 (de)
NL (1) NL6919421A (de)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3739966A (en) * 1971-08-17 1973-06-19 W Lynn Coin tube opener
US3924661A (en) * 1973-07-16 1975-12-09 Frank G Bornhoffer Flexible hose storage container
US4501360A (en) * 1983-04-27 1985-02-26 Claude Levy Packing, in particular for transporting and dispatching products, for example biological products
FR2595667A1 (fr) * 1986-03-12 1987-09-18 Suppo Steril Laboratoires Etui a ampoules
US4721204A (en) * 1987-01-02 1988-01-26 Shee William S Package for holding and using ampules
US4822235A (en) * 1987-02-24 1989-04-18 Hipp David R Device for breaking and stripping coins from a coin roll
US5127531A (en) * 1989-05-19 1992-07-07 Terumo Kabushiki Kaisha Fluid sample tube stand with holder support mechanism
US6739488B1 (en) * 2000-08-28 2004-05-25 Health Care Logistics, Inc. Tablet cutter
US20040216775A1 (en) * 2002-01-18 2004-11-04 Irwin Kotovsky Cane
US20050126949A1 (en) * 2003-12-05 2005-06-16 Camilla Maffei Box for a glass vials with a neck to be broken off equipped with an ensemble of tools for facilitating breaking of the neck of the vial
US20050287045A1 (en) * 2004-06-23 2005-12-29 Ricardo Levisman Easy-to-open glass ampoule and device
US20110009823A1 (en) * 2009-07-08 2011-01-13 Chong Colin A Reservoir filling systems and methods
US20110009825A1 (en) * 2009-07-08 2011-01-13 Medtronic Minimed, Inc. Reservoir filling systems and methods
WO2021101720A1 (en) * 2019-11-18 2021-05-27 Elanco Us Inc. Lyophilized cake in straight-walled vial
EP4049965A1 (de) * 2021-02-25 2022-08-31 Lutz Packaging GmbH Ampullenbehälter mit integriertem ampullenbrecher

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2542284B1 (fr) * 1983-03-10 1985-08-02 Dehais Claude Ampoule autocassable, et son procede de fabrication
FR2556281B1 (fr) * 1983-12-13 1986-05-23 Dehais Claude Machine pour effectuer, sur des pointes d'ampoules pharmaceutiques ou analogues, le depot d'un anneau de matiere; ensemble de telles machines
ES530426A0 (es) * 1983-03-10 1985-04-16 Dehais Claude Perfeccionamientos en las maquinas para elaborar ampollas farmaceuticas y similares y anpolla obtenida.

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2638022A (en) * 1952-02-15 1953-05-12 Reyes Severo Ampoule breaker
US2659253A (en) * 1949-12-07 1953-11-17 George H Myrick Apparatus for breaking frangible suture tubes
US2700972A (en) * 1949-11-19 1955-02-01 Joel W Haden Method and apparatus for holding, transporting, and breaking suture tubes

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2700972A (en) * 1949-11-19 1955-02-01 Joel W Haden Method and apparatus for holding, transporting, and breaking suture tubes
US2659253A (en) * 1949-12-07 1953-11-17 George H Myrick Apparatus for breaking frangible suture tubes
US2638022A (en) * 1952-02-15 1953-05-12 Reyes Severo Ampoule breaker

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3739966A (en) * 1971-08-17 1973-06-19 W Lynn Coin tube opener
US3924661A (en) * 1973-07-16 1975-12-09 Frank G Bornhoffer Flexible hose storage container
US4501360A (en) * 1983-04-27 1985-02-26 Claude Levy Packing, in particular for transporting and dispatching products, for example biological products
FR2595667A1 (fr) * 1986-03-12 1987-09-18 Suppo Steril Laboratoires Etui a ampoules
US4721204A (en) * 1987-01-02 1988-01-26 Shee William S Package for holding and using ampules
US4822235A (en) * 1987-02-24 1989-04-18 Hipp David R Device for breaking and stripping coins from a coin roll
US5127531A (en) * 1989-05-19 1992-07-07 Terumo Kabushiki Kaisha Fluid sample tube stand with holder support mechanism
US6739488B1 (en) * 2000-08-28 2004-05-25 Health Care Logistics, Inc. Tablet cutter
US20040216775A1 (en) * 2002-01-18 2004-11-04 Irwin Kotovsky Cane
US7367455B2 (en) * 2003-12-05 2008-05-06 Project S.A.S. Di Massimo Memichelli & C Box for glass vials with an ensemble of tools for facilitating breaking of the necks of the vials
US20050126949A1 (en) * 2003-12-05 2005-06-16 Camilla Maffei Box for a glass vials with a neck to be broken off equipped with an ensemble of tools for facilitating breaking of the neck of the vial
US7490723B2 (en) * 2004-06-23 2009-02-17 Ricardo Levisman Easy-to-open glass ampoule and device
US20050287045A1 (en) * 2004-06-23 2005-12-29 Ricardo Levisman Easy-to-open glass ampoule and device
US20110009823A1 (en) * 2009-07-08 2011-01-13 Chong Colin A Reservoir filling systems and methods
US20110009825A1 (en) * 2009-07-08 2011-01-13 Medtronic Minimed, Inc. Reservoir filling systems and methods
WO2011005880A3 (en) * 2009-07-08 2011-04-14 Medtronic Minimed, Inc. Reservoir filling systems and methods
US8167846B2 (en) 2009-07-08 2012-05-01 Medtronic Minimed, Inc. Reservoir filling systems and methods
CN102596286A (zh) * 2009-07-08 2012-07-18 美敦力迷你迈德公司 储液器填充系统及方法
US8393357B2 (en) 2009-07-08 2013-03-12 Medtronic Minimed, Inc. Reservoir filling systems and methods
US8512289B2 (en) 2009-07-08 2013-08-20 Medtronic Minimed, Inc. Reservoir filling systems and methods
CN102596286B (zh) * 2009-07-08 2014-06-25 美敦力迷你迈德公司 储液器填充系统及方法
US9494147B2 (en) 2009-07-08 2016-11-15 Medtronic Minimed, Inc. Reservoir filling systems and methods
WO2021101720A1 (en) * 2019-11-18 2021-05-27 Elanco Us Inc. Lyophilized cake in straight-walled vial
EP4049965A1 (de) * 2021-02-25 2022-08-31 Lutz Packaging GmbH Ampullenbehälter mit integriertem ampullenbrecher

Also Published As

Publication number Publication date
FR1600977A (de) 1970-08-03
LU60080A1 (de) 1970-02-23
DE1964856B2 (de) 1972-01-05
DE1964856C3 (de) 1972-08-10
NL6919421A (de) 1970-06-30
DE1964856A1 (de) 1970-08-06
BE743729A (de) 1970-06-24

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AS Assignment

Owner name: PASTEUR MERIEUX SERUMS AND VACCINES

Free format text: EFFECTIVE ON 05/10/1990 IN FRANCE;ASSIGNOR:INSTITUT MERIEUX;REEL/FRAME:005700/0077

Effective date: 19900405