Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
  • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
  • A61K8/85—Polyesters
• • C—CHEMISTRY; METALLURGY
  • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
  • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
  • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
  • C08G63/66—Polyesters containing oxygen in the form of ether groups
  • C08G63/668—Polyesters containing oxygen in the form of ether groups derived from polycarboxylic acids and polyhydroxy compounds
• • C—CHEMISTRY; METALLURGY
  • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
  • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
  • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers

Definitions

• the composition includes, in a physiologically acceptable vehicle a solution of a polyester of a polycarboxylic acid having at least three carboxyl groups with a polyalkylene ether polyol having a molecular weight of at least 400, the ester having a molecular weight of at least 600 and a neutralization equivalent from 200 to 5000.
• This invention relates to a composition for inhibiting at least in part the deposition of calculus on the surface of teeth and pertains more specifically to a composition comprising a physiologically acceptable vehicle and a solution in a suitable solvent of certain acidic polyesters of polyalkylene ether polyols.
• Dental calculus is a hard intractable deposit which accumulates on those tooth surfaces subject to little abrasion or wear under normal conditions. Calculus is formed at least partially from material contained in the saliva. Frequently these calculus deposits accumulate on those surfaces of teeth adjacent to gum tissue and tend to cause irritation, pain, and rupture of the gum tissue, and if allowed to persist, produce open areas between the root of the tooth and its supporting gum tissue. These areas, called periodontal pockets, may become filled with calculus which further aggravates the supporting gum tissue and in extreme cases can exert sufficient pressure against the supporting bone to cause it to resorb. Recession of the gum tissue from the root of the tooth may also occur. If damage to the tissues supporting the tooth is sufficiently severe, loss of the tooth may result. Even in less severe cases of periodontal or gum disease the affiicted individual may find it necessary to restrict his diet to soft foods, and in any event dental calculus deposits are cosmetically unattractive.
• esters of the present invention when applied to teeth inhibit at least in part the formation of calculus deposits on the surfaces of the teeth. While the theory of operation of the present invention may not be fully understood and applicants do not wish to be limited thereto, it is believed that the compositions of the present invention function by chemical sorption of the acid polyesters in dilute solution with the surface of the teeth to form an adherent coating which interferes with the normal mechanism for calculus deposition.
• the method by which the acidic polyesters are applied to the teeth is not critical and any method may be employed which allows the composition to achieve contact with the tooth surfaces.
• the composition may be applied in the form of a toothpaste, mouthwash, chewing gum, etc., and the time periods and temperatures normally employed for brushing the teeth or using a mouthwash suffice to permit the acidic polyester to sorb on the teeth.
• the amount of acid polyester present in the total composition is not critical; satisfactory results are obtained when the acid 3,542,917 Patented Nov. 24, 1970 polyester amounts to 0.1 to 20% by weight of the total composition including the vehicle.
• the solvent in which the acid polyester is dissolved in the composition may be water, ethyl alcohol, or other liquid solvent chemically inert to the acid polyester and suitable for use in the mouth. A mixture of two or more such solvents may be employed if desired.
• any of the usual additives employed in conventional mouthwashes or toothpastes may be present in the composltions of the present invention.
• Such additives include menthol, eucalyptol, methyl salicylate, and the like to provide flavor and astringency; thymol, boric acid, benzoic acid or other similar antiseptic; and any of the usual abrasive materials and thickeners employed in toothpaste.
• the polyesters of the present invention may be prepared from a variety of starting'materials but will be defined in terms of their alcohol and acid components as is usual in defining esters.
• the alcoholic component may be any polyalkylene ether having at least two hydroxyl groups, and having a weight average molecular weight of at least 400; among suitable materials are tetrahydric polyether alcohols of various molecular weights made by the ethoxylation of pentaerythritol, and trihydric polyether alcohols made by ethoxylation of glycerol; polyethylene glycol and polypropylene glycol of molecular weight 400 to 10,000 are particularly preferred.
• the acid component of the polyester may be any of a variety of polycarboxylic acids having three or more carboxyl groups such as citric, tricarballylic, mellitic, trimesic, trimellitic, acontic, pyromellitic, polyacrylic, and the like. These acids contain, except for the oxygen of the carboxyl and hydroxyl groups, only carbon and hydrogen.
• the useful esters are polyesters in the usual sense inasmuch as they contain a plurality of ester linkages at spaced intervals in the backbone or chain of carbon atoms of the molecule.
• the polyester of such alcohol and acid components contain some free unreacted carboxyl groups; the proportion of such carboxyl groups may be defined in terms of the neutralization equivalent of the polyester, that is the weight average molecular weight of the polyester divided by the number of free acidic groups in the molecule (Shriner and Fuson, Systematic Identification of Organic Compounds, 3rd ed. John Wiley, New York, 1948).
• the acid polyesters of the present invention should have a neutralization equivalent in the range of 200 to 5000.
• the carboxyl groups may be terminal groups or they may be pendent on the backbone of the polyester molecules.
• the weight average molecular weight of the polyesters preferably is at least 600.
• the acid polyesters may be prepared by esterifying the alcohol component with the appropriate acid, or by reacting the alcohol component with an acid halide or acid anhydride, the relative proportions of the reactant being chosen so that the number of hydroxyl groups in the alcoholic component is insufficient to react with all of the carboxyl or acyl halide or acid anhydride groups. If necessary, hydrolysis of residual acyl halide or acid anhydride groups may be carried out so that the finished polyester contains free carboxyl groups.
• composition for use on the teeth containing a solution of the acidic polyester, should have a pH of 2 to 7, that is, the hydrogen ion concentration in the composition should be such that its negative logarithm is from 2 to 7.
• the acid polyesters of the present invention were tested for effectiveness by immersing sound extracted human bicuspid teeth in human saliva at room temperature for stated time periods; at specified intervals the teeth were removed from the saliva and immersed for a specified time period (usually 30 seconds) in a solution of the desired acid polyester. Changes in the calcium content of the saliva were determined by analysis, and extent of deposition of calculus on the teeth was observed. The results are set forth in the following specific examples which are intended to illustrate more clearly the nature of the present invention.
• EXAMPLE 1 In a 100 ml. beaker were placed 30 grams (.005 mole) of poly (ethylene glycol) 6000, 1 gram (.005 mole) of pyromellitic dianhydride and 0.1 ml. of 35 percent aqueous hydrochloric acid as a catalyst. The reactants were heated to 90 C., and allowed to remain at that temperature for a period of four hours with agitation. The product had a melting point of 52.5 C. and a neutralization equivalent of 2080. The infrared spectrum of the product showed it to be an ester of poly (ethylene glycol) and pyromellitic acid.
• a 0.5 percent aqueous solution of the ester was prepared.
• Two clean, sound bicuspid teeth were treated by dipping them in this solution 30 seconds daily for a period of three weeks.
• the teeth were dipped and withdrawn at two second intervals in human saliva containing 62.4 parts per million (p.p.m.) calcium.
• the calcium content of the saliva had decreased only to 50.8 and 56.0 p.p.m., respectively.
• the treated teeth gained 0.24 and 0.31 percent in weight, and mechanically removed scrapings were found to contain only 0.12 and 0.16 milligram calcium, respectively.
• EXAMPLE 2 A similar test was conducted with the ester described in Example 1, using the same techniques, with teeth and saliva obtained from other people.
• the fresh saliva used in this experiment contained 48.8 p.p.m. calcium. After three weeks contact with the teeth the calcium content of the saliva exposed to the treated teeth decreased to 28.8 p.p.m. while that exposed to untreated teeth decreased to 13.6 p.p.m.
• the untreated teeth had appreciably larger calculus deposits than the treated teeth.
• EXAMPLE 3 A test similar to that described in Example 1 was conducted except that a 1 percent aqueous solution of the ester was used.
• the saliva used in this test had an initial calcium content of 43 p.p.m. which decreased to 27 p.p.m. when exposed to the treated teeth.
• the calcium content decreased to 16 p.p.m.
• the treated teeth appeared substantially cleaner and relatively free of calculus deposits when compared with the untreated teeth in this test after two weeks exposure.
• EXAMPLE 4 A test similar to that described in Example 1 was conducted except that a 2 percent aqueous solution of the ester was used.
• the saliva used in this test had an initial calcium content of 61 p.p.m. which decreased to 55 p.p.m. when exposed to the treated teeth, but decreased to only 30 p.p.m. when exposed to untreated teeth. correspondingly, the treated teeth appeared substantially cleaner and relatively free of calculus deposits when com- 4 pared with the untreated teeth in this test after two weeks exposure.
• EXAMPLE 5 A test similar to that described in Example 1 was conducted except that a 4 percent aqueous solution of the ester was used.
• the saliva used in this test had an initial calcium content of 49 which decreased to 36 p.p.m. when exposed to the treated teeth, and decreased to 27 p.p.m. when exposed to untreated teeth.
• the treated teeth appeared substantially cleaner and relatively free of calculus deposits when compared with the untreated teeth in this test after two weeks exposure.
• EXAMPLE 6 A test similar to that described in Example 1 was conducted except that in place of the 0.5 percent aqueous solution of ester there was employed a mouthwash having the following composition.
• the saliva used in this test had an initial calcium content of 58 p.p.m. which did not decrease when exposed to the treated teeth. In contrast, that portion of the saliva sample exposed to untreated teeth decreased in content to 42 p.p.m. after the test. Correspondingly, the treated teeth appeared substantially cleaner and relatively free of calculus deposits when compared with the untreated teeth in this test after two Weeks exposure.
• EXAMPLE 7 In a ml. beaker were placed 30 grams .005 mole) poly (ethylene glycol) 6000, and 1.2 grams (.005 mole) aconityl chloride. The mixture was heated to 70 C. and agitated at that temperature for 2 hours. There was then added to the reaction mixture 1.8 grams (0.1 mole) of water and the mixture was heated to C. for about 15 minutes until evolution of hydrogen chloride ceased. The resulting ester product had a melting point of 47.5 C. and a neutralization equivalent of 387. A five percent aqueous solution of the ester was prepared and tested by the procedure of Example 1. The saliva used in this test had an initial calcium content of 67 p.p.m. which decreased to 55 p.p.m. when exposed to the treated teeth, and to 49 p.p.m. when exposed to untreated teeth. Correspondingly, the treated teeth appeared substantially cleaner and relatively free of calculus deposits when compared with the untreated teeth in this test after three weeks exposure.
• EXAMPLE 8 In a 100 ml. beaker were placed 31 grams (.016 mole) poly (propylene glycol) with a molecular weight of 2000, 3.4 grams (.016 mole) pyromellitic dianhydride and .1 ml. 35 percent aqueous hydrochloric acid. The mixture was heated to C. for 35 minutes and subsequently allowed to cool. The resulting ester product was an amber solid which had a melting point of 62.5 C. and a neutralization equivalent of 930. A 0.5 aqueous solution of the poly (propylene glycol) ester of pyromellitic acid described above was prepared and tested as in Example 1. The saliva used in this test had an initial calcium content of 32 p.p.m.
• a composition for treating teeth which comprises a physiologically acceptable vehicle containing in solution from 0.1 to 20 percent by weight of a polyester of (1) a polycarboxylic acid having three to six carboxyl groups with (2) a polyalkylene ether having two to four hydroxyl groups and having a molecular weight of 400 to 10,000, said ester having a molecular weight of at least 600 and a neutralization equivalent from 200 to 5,000.
• composition as claimed in claim 5 in which said acid is pyromellitic.
• a method of treating teeth to reduce calculus formation thereon which comprises contacting the surface thereof with a composition as claimed in claim 1.

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• Health & Medical Sciences (AREA)
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• Chemical Kinetics & Catalysis (AREA)
• Medicinal Chemistry (AREA)
• Polymers & Plastics (AREA)
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• Epidemiology (AREA)
• Oral & Maxillofacial Surgery (AREA)
• Cosmetics (AREA)

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Cited By (14)

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Citations (2)

• 1968
  • 1968-06-20 US US738389A patent/US3542917A/en not_active Expired - Lifetime
• 1969
  • 1969-06-12 CA CA054177A patent/CA920513A/en not_active Expired
  • 1969-06-16 GB GB30299/69A patent/GB1256267A/en not_active Expired
  • 1969-06-18 BE BE734721D patent/BE734721A/xx unknown
  • 1969-06-19 SE SE08789/69A patent/SE356212B/xx unknown
  • 1969-06-19 CH CH940369A patent/CH517490A/fr not_active IP Right Cessation
  • 1969-06-19 NL NL6909428A patent/NL6909428A/xx unknown
  • 1969-06-20 FR FR6920799A patent/FR2011342A1/fr not_active Withdrawn
  • 1969-06-20 DE DE19691931451 patent/DE1931451A1/de active Granted
  • 1969-06-20 AT AT587369A patent/AT291442B/de not_active IP Right Cessation
  • 1969-06-20 BR BR209992/69A patent/BR6909992D0/pt unknown

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