US3418083A - Hydrophobic test strip for analyzing whole blood - Google Patents
Hydrophobic test strip for analyzing whole blood Download PDFInfo
- Publication number
- US3418083A US3418083A US535010A US53501066A US3418083A US 3418083 A US3418083 A US 3418083A US 535010 A US535010 A US 535010A US 53501066 A US53501066 A US 53501066A US 3418083 A US3418083 A US 3418083A
- Authority
- US
- United States
- Prior art keywords
- whole blood
- impregnated
- agent
- blood
- test strip
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000004369 blood Anatomy 0.000 title claims description 28
- 239000008280 blood Substances 0.000 title claims description 28
- 230000002209 hydrophobic effect Effects 0.000 title description 6
- 239000000126 substance Substances 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims description 17
- 239000002250 absorbent Substances 0.000 claims description 14
- 239000003795 chemical substances by application Substances 0.000 claims description 10
- 238000001514 detection method Methods 0.000 claims description 10
- 229920001296 polysiloxane Polymers 0.000 claims description 7
- 239000004890 Hydrophobing Agent Substances 0.000 claims description 5
- 239000003925 fat Substances 0.000 claims description 4
- 239000003921 oil Substances 0.000 claims description 4
- 239000001993 wax Substances 0.000 claims description 4
- 238000009877 rendering Methods 0.000 claims description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 24
- 230000002745 absorbent Effects 0.000 description 13
- 238000005470 impregnation Methods 0.000 description 10
- 238000006243 chemical reaction Methods 0.000 description 8
- 229940039227 diagnostic agent Drugs 0.000 description 8
- 239000000032 diagnostic agent Substances 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 7
- NUIURNJTPRWVAP-UHFFFAOYSA-N 3,3'-Dimethylbenzidine Chemical compound C1=C(N)C(C)=CC(C=2C=C(C)C(N)=CC=2)=C1 NUIURNJTPRWVAP-UHFFFAOYSA-N 0.000 description 6
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 6
- 102000003992 Peroxidases Human genes 0.000 description 5
- 229930182830 galactose Natural products 0.000 description 5
- 108040007629 peroxidase activity proteins Proteins 0.000 description 5
- 229960005190 phenylalanine Drugs 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 4
- 239000012153 distilled water Substances 0.000 description 4
- 210000003743 erythrocyte Anatomy 0.000 description 4
- 239000008103 glucose Substances 0.000 description 4
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 4
- 235000008729 phenylalanine Nutrition 0.000 description 4
- 108010015776 Glucose oxidase Proteins 0.000 description 3
- 239000004366 Glucose oxidase Substances 0.000 description 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 3
- 229940116332 glucose oxidase Drugs 0.000 description 3
- 235000019420 glucose oxidase Nutrition 0.000 description 3
- 235000013905 glycine and its sodium salt Nutrition 0.000 description 3
- 239000000553 indicators and reagents Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 229910000160 potassium phosphate Inorganic materials 0.000 description 3
- 235000011009 potassium phosphates Nutrition 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 239000002023 wood Substances 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 239000010425 asbestos Substances 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 238000002405 diagnostic procedure Methods 0.000 description 2
- 239000012188 paraffin wax Substances 0.000 description 2
- 229910052895 riebeckite Inorganic materials 0.000 description 2
- 229940045136 urea Drugs 0.000 description 2
- 102000003914 Cholinesterases Human genes 0.000 description 1
- 108090000322 Cholinesterases Proteins 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 108020005199 Dehydrogenases Proteins 0.000 description 1
- 108010015133 Galactose oxidase Proteins 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 108010008292 L-Amino Acid Oxidase Proteins 0.000 description 1
- 102000007070 L-amino-acid oxidase Human genes 0.000 description 1
- 102000045595 Phosphoprotein Phosphatases Human genes 0.000 description 1
- 108700019535 Phosphoprotein Phosphatases Proteins 0.000 description 1
- 102000003929 Transaminases Human genes 0.000 description 1
- 108090000340 Transaminases Proteins 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 1
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 229940048961 cholinesterase Drugs 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 210000000624 ear auricle Anatomy 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 229940116269 uric acid Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/54—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
- G01N33/521—Single-layer analytical elements
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/805—Test papers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
- Y10T436/144444—Glucose
Definitions
- This invention relates to a diagnostic agent for the detection of biochemical and chemical components in whole blood and more particularly relates to a test strip for use in the detection of chemical and biochemical components in whole blood, a process for the preparation of such test strips and a method for using the same.
- a further object of the invention is to provide a new and improved test paper strip for use in detecting chemical and biochemical components of whole blood characterized by the extreme ease with which they are produced and used.
- agents which can be used for the hydrophobing of the absorbent carriers are natural and synthetic fats, oils and waxes, as well as, and preferably, paraflins, silicones and mixtures thereof.
- agents which can be used for the hydrophobing of the absorbent carriers are natural and synthetic fats, oils and waxes, as well as, and preferably, paraflins, silicones and mixtures thereof.
- test paper strips can be hydrophobed following impregnation with the indicator solutions.
- dependable and satisfactory test paper strips are also obtained when the indicator dyestuff, together with the hydrophobing agent, is employed as impregnant being applied onto test paper strips which have already been impregnated with the other reagents.
- the hydrophobed diagnostic agents there can be used not only filter paper, but also other absorbent carriers, such as asbestos paper and Wood rodlets.
- other absorbent carriers such as asbestos paper and Wood rodlets.
- the pores of the wood can sometimes be disturbing since red blood corpuscles collect therein and can only be wiped off or rinsed out with difficulty.
- the diagnostic agents according to the present invention can be utilized for all of the clinical tests which are of importance in the analysis of blood, especially for the clinical screening tests, as for example, the determination of glucose, galactose, phenyl-alanine, serum cholinesterase, urea and uric acid, as well as for phosphatases, transaminases, dehydrogenases, trypsin, histidine, and the like.
- hydrophobed diagnostic agents according to the invention in comparison with all diagnostic agents which have previously been suggested or used for the investigation of whole blood, is the extreme ease with which they are produced and used since sensitive and expensive special coatings or sealings are not necessary.
- EXAMPLE 1 Production of a test strip suitable for the detection of glucose in whole blood.
- Schleicher and Schiill filter paper No. 2312 was successively impregnated with impregnation solutions I and II, dried and cut up into strips of mm. width.
- EXAMPLE 2 Production of a test strip suitable for the detection of galactose in whole blood.
- Impregnation solution I Methylene chloride ad 100.0 ml.
- Schleicher and Schiill filter paper No. 2312 was successively impregnated with impregnation solutions -I and II, dried and cut up into strips.
- Blood containing galactose obtained as described above was applied to the test strips in a manner analogous to that described in Example 1 and the strips further processed as therein set forth.
- the test strips evidence the galactose content of the blood by a blue color reaction, the intensity of which is directly related to the amount of galactose present.
- test strip was produced in exactly the same way as described in Example 1.
- the test strips thereby obtained had the same properties as those of Example 1 and produced the same results.
- Phenyl-alanine test paper Filter paper was impregnated with L-amino acid oxidase, peroxidase and o-tolidine, together with a 0.2 molar phosphate buffer having a pH of 6.5. The dried paper was subsequently impregnated with a solution of 4% paraflin in methylene chloride. The phenyl-alanine test paper obtained in this manner demonstrated, upon the application thereto of blood, containing phenylalanine in a manner analogous to that described in Example 1, the content of L-phenyl-alanine by a blue color reaction which could be quantitatively evaluated by reference to a color table.
- a diagonstic agent for use in the detection of chemical and biochemical components in whole blood comprising an absorbent carrier support impregnated with a composition forming color in response to said chemical component and treated with a hydrophobing agent rendering the impregnated absorbent carrier hydrophobic, wherein said hydrophobing agent is a member selected from the group consisting of natural and synthetic fats, oils, waxes, parafiins, silicones, and mixtures thereof.
- said absorbent carrier support is a member selected from the group consisting of filter paper, asbestos paper, and wood rodlets.
- the method of providing diagnostic agents for use in the detection of chemical and biochemical components in whole blood comprising impregnating an absorbent carrier support with a composition forming color in response to said chemical component and thereafter treating said impregnated carrier support with a hydrophobic agent rendering the impregnated carrier support hydrophobic, wherein said hydrophobic agent is a member selected from the group consisting of natural and synthetic fats, oils, waxes, paraffins, silicones and mixtures thereof.
- composition for forming color in response to said chemical component comprises a mixture of specific reagents and indicators.
- composition for forming color in response to said chemical component comprises a mixture of specific reagents and indicators and wherein said absorbent carrier is first 3,418,083 5 6 impregnated with said specific reagents and thereafter MORRIS O.
- WOLK Primary Examiner. treated with the indicator and hydrophobing agent.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Emergency Medicine (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE1965B0082023 DE1598048B2 (de) | 1965-05-20 | 1965-05-20 | Diagnostisches mittel zum nachweis von inhaltsstoffen des vollblutes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US3418083A true US3418083A (en) | 1968-12-24 |
Family
ID=6981343
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US535010A Expired - Lifetime US3418083A (en) | 1965-05-20 | 1966-03-17 | Hydrophobic test strip for analyzing whole blood |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US3418083A (ja) |
| AT (1) | AT262511B (ja) |
| BE (1) | BE681364A (ja) |
| CH (1) | CH458793A (ja) |
| DE (1) | DE1598048B2 (ja) |
| ES (1) | ES326843A1 (ja) |
| FI (1) | FI41879C (ja) |
| FR (1) | FR1484845A (ja) |
| GB (1) | GB1083683A (ja) |
| LU (1) | LU51140A1 (ja) |
| NL (2) | NL6606814A (ja) |
| NO (1) | NO116823B (ja) |
| SE (1) | SE326318B (ja) |
Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3607093A (en) * | 1968-02-15 | 1971-09-21 | Schering Corp | Devices for testing biological liquids |
| US3913393A (en) * | 1972-02-25 | 1975-10-21 | Omnium Tech Administrat | Emulsion layer of coloured indicators for determining spectra of the effects of a fluid on a surface |
| US3917453A (en) * | 1974-08-16 | 1975-11-04 | Polaroid Corp | Method and device for determining the concentration of a substance in a fluid |
| US4017261A (en) * | 1974-10-16 | 1977-04-12 | Lachema, Narodni Podnik | Biological diagnostic test strip and method of producing same |
| US4160008A (en) * | 1978-01-26 | 1979-07-03 | Miles Laboratories, Inc. | Multilayered test device for determining the presence of a liquid sample component, and method of use |
| US4234313A (en) * | 1974-11-11 | 1980-11-18 | Burroughs Wellcome Co. | Device and method for quantitative uric acid testing |
| EP0054773A1 (en) * | 1980-12-15 | 1982-06-30 | Miles Laboratories, Inc. | Method and device for detecting glucose concentration |
| US4385114A (en) * | 1974-12-21 | 1983-05-24 | Boehringer Mannheim Gmbh | Oxidation indicators comprising 3,3',5,5'-tetraalkylbenzidine compounds |
| EP0133700A2 (en) * | 1983-08-10 | 1985-03-06 | E.I. Du Pont De Nemours And Company | Improved multilayered test device for detecting analytes in liquid test samples |
| US4557900A (en) * | 1982-09-28 | 1985-12-10 | Cardiovascular Devices, Inc. | Optical sensor with beads |
| US4689309A (en) * | 1985-09-30 | 1987-08-25 | Miles Laboratories, Inc. | Test device, method of manufacturing same and method of determining a component in a sample |
| US4965087A (en) * | 1982-12-07 | 1990-10-23 | Avl Ag | Method of making a sensor element for fluorescence-optical measurements |
| US5312759A (en) * | 1989-12-20 | 1994-05-17 | Iatron Laboratories, Inc. | Method for measurement of fructosamines using 1,2-quinones |
| WO1998002249A1 (en) * | 1996-07-17 | 1998-01-22 | Robert William Cunningham | New test device for mass screening |
| US5962215A (en) * | 1996-04-05 | 1999-10-05 | Mercury Diagnostics, Inc. | Methods for testing the concentration of an analyte in a body fluid |
| US20030211006A1 (en) * | 2002-05-10 | 2003-11-13 | Suyue Qian | Multilayer reagent test strips that include at least one fluid flow control layer and methods for using the same |
| WO2006000999A1 (en) * | 2004-06-24 | 2006-01-05 | University College Cork - National University Of Ireland, Cork | Support for biological or chemical arrays having increased spot quality |
| WO2013045443A1 (en) | 2011-09-28 | 2013-04-04 | Emilia Bramanti | Measurement of lactic acid in biological fluids |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5926061A (ja) * | 1982-08-02 | 1984-02-10 | Eiken Kagaku Kk | 体液中の成分定量用試験片 |
| CA1271398A (en) * | 1985-06-28 | 1990-07-10 | James E. Jones | Diagnostic test device |
| DE3800661A1 (de) * | 1988-01-13 | 1989-07-27 | Zuckerindustrie Verein | Teststreifen aus einem saugfaehigen werkstoff oder mit einer saugfaehigen beschichtung aus diesem werkstoff sowie verfahren zu seiner herstellung |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3092465A (en) * | 1960-03-25 | 1963-06-04 | Miles Lab | Diagnostic test device for blood sugar |
| US3298789A (en) * | 1964-12-14 | 1967-01-17 | Miles Lab | Test article for the detection of glucose |
-
0
- NL NL129843D patent/NL129843C/xx active
-
1965
- 1965-05-20 DE DE1965B0082023 patent/DE1598048B2/de active Granted
-
1966
- 1966-03-17 US US535010A patent/US3418083A/en not_active Expired - Lifetime
- 1966-05-12 SE SE06543/66A patent/SE326318B/xx unknown
- 1966-05-16 FI FI661290A patent/FI41879C/fi active
- 1966-05-17 CH CH714966A patent/CH458793A/de unknown
- 1966-05-17 ES ES0326843A patent/ES326843A1/es not_active Expired
- 1966-05-18 NL NL6606814A patent/NL6606814A/xx unknown
- 1966-05-18 LU LU51140A patent/LU51140A1/xx unknown
- 1966-05-18 FR FR62067A patent/FR1484845A/fr not_active Expired
- 1966-05-18 AT AT474366A patent/AT262511B/de active
- 1966-05-18 GB GB22112/66A patent/GB1083683A/en not_active Expired
- 1966-05-18 NO NO163069A patent/NO116823B/no unknown
- 1966-05-20 BE BE681364D patent/BE681364A/xx unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3092465A (en) * | 1960-03-25 | 1963-06-04 | Miles Lab | Diagnostic test device for blood sugar |
| US3298789A (en) * | 1964-12-14 | 1967-01-17 | Miles Lab | Test article for the detection of glucose |
Cited By (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3607093A (en) * | 1968-02-15 | 1971-09-21 | Schering Corp | Devices for testing biological liquids |
| US3913393A (en) * | 1972-02-25 | 1975-10-21 | Omnium Tech Administrat | Emulsion layer of coloured indicators for determining spectra of the effects of a fluid on a surface |
| US3917453A (en) * | 1974-08-16 | 1975-11-04 | Polaroid Corp | Method and device for determining the concentration of a substance in a fluid |
| US4017261A (en) * | 1974-10-16 | 1977-04-12 | Lachema, Narodni Podnik | Biological diagnostic test strip and method of producing same |
| US4234313A (en) * | 1974-11-11 | 1980-11-18 | Burroughs Wellcome Co. | Device and method for quantitative uric acid testing |
| US4385114A (en) * | 1974-12-21 | 1983-05-24 | Boehringer Mannheim Gmbh | Oxidation indicators comprising 3,3',5,5'-tetraalkylbenzidine compounds |
| US4160008A (en) * | 1978-01-26 | 1979-07-03 | Miles Laboratories, Inc. | Multilayered test device for determining the presence of a liquid sample component, and method of use |
| EP0054773A1 (en) * | 1980-12-15 | 1982-06-30 | Miles Laboratories, Inc. | Method and device for detecting glucose concentration |
| US4557900A (en) * | 1982-09-28 | 1985-12-10 | Cardiovascular Devices, Inc. | Optical sensor with beads |
| US4965087A (en) * | 1982-12-07 | 1990-10-23 | Avl Ag | Method of making a sensor element for fluorescence-optical measurements |
| EP0133700A2 (en) * | 1983-08-10 | 1985-03-06 | E.I. Du Pont De Nemours And Company | Improved multilayered test device for detecting analytes in liquid test samples |
| EP0133700A3 (en) * | 1983-08-10 | 1987-10-28 | E.I. Du Pont De Nemours And Company | Improved multilayered test device for detecting analytes in liquid test samples |
| US4689309A (en) * | 1985-09-30 | 1987-08-25 | Miles Laboratories, Inc. | Test device, method of manufacturing same and method of determining a component in a sample |
| US5312759A (en) * | 1989-12-20 | 1994-05-17 | Iatron Laboratories, Inc. | Method for measurement of fructosamines using 1,2-quinones |
| US5962215A (en) * | 1996-04-05 | 1999-10-05 | Mercury Diagnostics, Inc. | Methods for testing the concentration of an analyte in a body fluid |
| US6818180B2 (en) | 1996-04-05 | 2004-11-16 | Roche Diagnostics Operations, Inc. | Devices for testing for the presence and/or concentration of an analyte in a body fluid |
| WO1998002249A1 (en) * | 1996-07-17 | 1998-01-22 | Robert William Cunningham | New test device for mass screening |
| US20030211006A1 (en) * | 2002-05-10 | 2003-11-13 | Suyue Qian | Multilayer reagent test strips that include at least one fluid flow control layer and methods for using the same |
| WO2006000999A1 (en) * | 2004-06-24 | 2006-01-05 | University College Cork - National University Of Ireland, Cork | Support for biological or chemical arrays having increased spot quality |
| WO2013045443A1 (en) | 2011-09-28 | 2013-04-04 | Emilia Bramanti | Measurement of lactic acid in biological fluids |
| US9234887B2 (en) | 2011-09-28 | 2016-01-12 | Power Fit S.R.L. | Measurement of lactic acid in biological fluids |
| US9702848B2 (en) | 2011-09-28 | 2017-07-11 | Power Fit S.R.L. | Measurement of lactic acid in biological fluids |
Also Published As
| Publication number | Publication date |
|---|---|
| DE1598048A1 (de) | 1969-06-12 |
| DE1598048B2 (de) | 1977-06-16 |
| FR1484845A (fr) | 1967-06-16 |
| FI41879B (ja) | 1969-12-01 |
| AT262511B (de) | 1968-06-10 |
| SE326318B (ja) | 1970-07-20 |
| GB1083683A (en) | 1967-09-20 |
| ES326843A1 (es) | 1967-03-16 |
| NL6606814A (ja) | 1966-11-21 |
| NL129843C (ja) | |
| NO116823B (ja) | 1969-05-27 |
| FI41879C (fi) | 1970-03-10 |
| CH458793A (de) | 1968-06-30 |
| LU51140A1 (ja) | 1966-07-18 |
| BE681364A (ja) | 1966-11-21 |
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