Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
  • A61Q17/005—Antimicrobial preparations
• • A—HUMAN NECESSITIES
  • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
  • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
  • A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
  • A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
  • A23L3/3409—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of gases, e.g. fumigation; Compositions or apparatus therefor
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
  • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K9/00—Medicinal preparations characterised by special physical form
  • A61K9/10—Dispersions; Emulsions
  • A61K9/12—Aerosols; Foams
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
  • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
  • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
  • A61L2/20—Gaseous substances, e.g. vapours
  • A61L2/206—Ethylene oxide
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
  • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
  • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
  • A61L2/22—Phase substances, e.g. smokes, aerosols or sprayed or atomised substances

Definitions

• Another advantage of the present invention is the fact that adequate proportions of alkylene oxide are retained within the pressurized dispenser throughout its use to prevent any contamination of the contents.
• alkylene oxides useful in this invention are ethylene oxide and propylene oxide, particularly useful, however, is ethylene oxide which compound is considered the more active sterilant.
• the alkylene oxides are preferably blended with an inert gaseous propellant such as carbon dioxide or nitrogen. Particularly useful, arethe commercially available Freon and Genitron propellants such as monochlorodifluroethane, trichloromonofluromethane and mixtures thereof.
• the alkylene oxide is mixed with the propellant by introducing 40 to 1000 p.p.m. of alkylene oxide into a charged or liquified' cylinder of said propellant. Then the propellant-alkylene oxide mixture, normally in a liquid state, is introduced into the individual aerosol dispenser containing the topical pharmaceutical preparation and sealed therein under an internal pressure ,pf 15 to 100 p.s.i.g. by conventional means.
• the alkylene oxide-propellant mixture will effectively sterilize the aerosol preparation in 2 to 60 days, the actual time for any particular preparation will be dependent upon the concentration of alkylene oxide and internal pressure of the aerosol dis- 4 to 5 weeks under normal aerosol Even at minimum concentrations of about 20 p.p.m. complete sterilization can be expected within about 2
• the following example is illustrative of the present in vention:
• Example I To determine the effectiveness of minute non-toxic concentrations of ethylene oxide as a sterilant, a topical pharmaceutical preparation having the following formulation was prepared:
• the aerosol units to be tested were inoculated with spores of Bacillus subtilis. Inoculum 5,625,000 cells/ml. of the above formulation. (Spore count was determined by plate dilution method using heart infusion agar and distilled Water pH 5.7.) Bacillus subtilis spores were selected because of their known resistance to the antimicrobial agentFuracin. After inoculation, the test units were filled with 1.25 oz. avoir. of the above glycol-Furacin solution then the 25% by weight of trichloromonofluromethane was added followed by addition of 25% by weight of the monochlorodifluromethane ethylene oxide mixture.
• the monochlorodifluroethane-ethylene oxide mixtures were prepared via a pressure burette such that the total concentration in the test units was varied from 500 to 0 p.p.m. The 0 p.p.m. being used as a control. Initial pressure within the test units was 18 p.s.i.g.
• one 'cc. of the inoculated sample was sprayed into a Millipore filter and washed with one liter of sterile distilledwater. In this way, the Furacin was washed through; the filter leaving B. subtilz's spores on the filter. The filter was transferred to thioglycollate media'and incubated for 72 hours at 37 C. and checked for sterility. The units containing 500; 100 and 50 ppm. ethylene oxide were sterile; the unit containing p.p.m. ethylene oxide was.
• Example 11 To further illustrate. thepresent invention 115 0 aerosol samples containing Formulation A were prepared under non-sterile commercial packaging conditions by first preparing and filling the sample units with 1.25 oz. avoir.-of the 0.2% Furacin in hexylene glycol-polyethylene glycol base and then introducing the propellant (2, 5 by weight of trichloromonofiuromethane was added followed by addition of 25% by Weight of a monochlorodifluromethane- J ethylene oxide mixture) containing 70 ppm. ethylene oxide, such that the final concentration of ethylene oxide within the aerosol was.35 p.p.'m.

Landscapes

• Health & Medical Sciences (AREA)
• Chemical & Material Sciences (AREA)
• Life Sciences & Earth Sciences (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Veterinary Medicine (AREA)
• Epidemiology (AREA)
• Chemical Kinetics & Catalysis (AREA)
• General Chemical & Material Sciences (AREA)
• Dispersion Chemistry (AREA)
• Birds (AREA)
• Food Science & Technology (AREA)
• Polymers & Plastics (AREA)
• Engineering & Computer Science (AREA)
• Dermatology (AREA)
• Nutrition Science (AREA)
• Medicinal Chemistry (AREA)
• Pharmacology & Pharmacy (AREA)
• Medicinal Preparation (AREA)
• Cosmetics (AREA)

Priority Applications (6)

Applications Claiming Priority (1)

Publications (1)

Family

ID=22545078

Family Applications (1)

Country Status (6)

Cited By (2)

Families Citing this family (4)

Citations (3)

• 1961
  • 1961-11-16 US US152936A patent/US3169906A/en not_active Expired - Lifetime
• 1962
  • 1962-11-06 GB GB41919/62A patent/GB989036A/en not_active Expired
  • 1962-11-12 DE DEN22339A patent/DE1287255B/de active Pending
  • 1962-11-13 BR BR144633/62A patent/BR6244633D0/pt unknown
  • 1962-11-14 DK DK490162AA patent/DK103089C/da active
  • 1962-11-16 AT AT902162A patent/AT255659B/de active

Patent Citations (3)

Also Published As

Similar Documents