US20220023039A1 - Two-part bi-leaflet heart valve prostheses - Google Patents
Two-part bi-leaflet heart valve prostheses Download PDFInfo
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- US20220023039A1 US20220023039A1 US17/494,770 US202117494770A US2022023039A1 US 20220023039 A1 US20220023039 A1 US 20220023039A1 US 202117494770 A US202117494770 A US 202117494770A US 2022023039 A1 US2022023039 A1 US 2022023039A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
- A61F2/2418—Scaffolds therefor, e.g. support stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2427—Devices for manipulating or deploying heart valves during implantation
- A61F2/2436—Deployment by retracting a sheath
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2427—Devices for manipulating or deploying heart valves during implantation
- A61F2/2439—Expansion controlled by filaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0008—Fixation appliances for connecting prostheses to the body
- A61F2220/0016—Fixation appliances for connecting prostheses to the body with sharp anchoring protrusions, e.g. barbs, pins, spikes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0028—Shapes in the form of latin or greek characters
- A61F2230/0054—V-shaped
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/006—Additional features; Implant or prostheses properties not otherwise provided for modular
Abstract
A two-part heart valve prosthesis comprising a self-expanding valve cage stent and a bi-leaflet tissue valve secured thereto. A method for delivering a heart valve prosthesis to a native valve annulus comprises expanding an expandable frame at the native valve annulus and positioning a replacement heart valve within the expandable frame. The expandable frame preferably includes a first anchoring portion that is positioned on a first side of the native valve annulus and a second anchoring portion that is positioned on a second side of the native valve annulus. The first anchoring portion engages tissue on the first side of the native valve annulus and the second anchoring portion engages tissue on the second side of the native valve annulus for securing the expandable frame to the native valve annulus. The replacement heart valve comprises a plurality of leaflets for replacing the function of the native valve.
Description
- This application is a continuation of U.S. application Ser. No. 16/503,179, filed Jul. 3, 2019, now U.S. Pat. No. 11,141,265, which is a continuation of U.S. application Ser. No. 15/221,435, filed Jul. 27, 2016, now U.S. Pat. No. 10,350,065, which is a continuation of U.S. application Ser. No. 12/309,680, filed Aug. 20, 2009, now abandoned, which is a national stage entry of International Application No. PCT/US2007/016855, filed Jul. 27, 2007, which designates the United States and was published in English by the International Bureau on Jan. 31, 2008 as WO 2008/013915, which claims the benefit of U.S. Provisional Application No. 60/833,791, filed Jul. 28, 2006, which is incorporated herein by reference in its entirety.
- The present invention relates to heart valve prostheses, preferably to aortic valve prostheses. More specifically, the invention relates to heart valve prostheses that can be implanted percutaneously by means of a catheter from a remote location without opening the chest cavity.
- Heart valve surgery is used to repair or replace diseased heart valves. Valve surgery is an open-heart procedure conducted under general anesthesia. An incision is made through the patient's sternum (sternotomy), and the patient's heart is stopped while blood flow is rerouted through a heart-lung bypass machine.
- Valve replacement may be indicated when there is a narrowing of the native heart valve, commonly referred to as stenosis, or when the native valve leaks or regurgitates. When replacing the valve, the native valve is excised and replaced with either a biologic or a mechanical valve. Mechanical valves require lifelong anticoagulant medication to prevent clot formation around the valve, which can lead to thromboembolic complications and catastrophic valve failure. Biologic tissue valves typically do not require such medication. Tissue valves can be obtained from cadavers (homografts) or can be from pigs (porcine valve) and cows (bovine pericardial valves). Recently equine pericardium has also been used for making valves. These valves are designed to be attached to the patient using a standard surgical technique.
- Valve replacement surgery is a highly invasive operation with significant concomitant risk. Risks include bleeding, infection, stroke, heart attack, arrhythmia, renal failure, and adverse reactions to the anesthesia medications, as well as sudden death. Two to five percent of patients die during surgery.
- Post-surgery, patients temporarily may be confused due to emboli and other factors associated with the heart-lung machine. The first two to three days following surgery are spent in an intensive care unit where heart functions can be closely monitored. The average hospital stay is between one and two weeks, with several more weeks to months required for complete recovery.
- In recent years, advancements in minimally invasive, endoaortic, surgery interventional cardiology, and intervention radiology have encouraged some investigators to pursue percutaneous replacement of the aortic heart valve. Percutaneous Valve Technologies (“PVT”) of Fort Lee, N.J., has developed a balloon-expandable stent integrated with a bioprosthetic valve, which is the subject of U.S. Pat. Nos. 5,411,552, 5,840,081, 6,168,614, and 6,582,462 to Anderson et al. The stent/valve device is deployed across the native diseased valve to permanently hold the valve open, thereby alleviating a need to excise the native valve and to position the bioprosthetic valve in place of the native valve. PVT's device is designed for delivery in a cardiac catheterization laboratory under local anesthesia using fluoroscopic guidance, thereby avoiding general anesthesia and open-heart surgery. The device was first implanted in a patient in April of 2002.
- PVT's device suffers from several drawbacks. Deployment of PVT's stent has several drawbacks, including that there is very little control over its deployment. This lack of control can endanger the coronary ostia above the aortic valve and the anterior leaflet of the mitral valve below the aortic valve.
- Another drawback of the PVT device is its relatively large cross-sectional delivery profile. This is largely due to fabricating the tri-leaflet pericardial valve inside a robust stainless steel stent. Considering they have to be durable, the materials for the valve and the stent are very bulky, thus increasing the profile of the device. The PVT system's stent/valve combination is mounted onto a delivery balloon, making retrograde delivery through the aorta challenging. An antegrade transseptal approach may therefore be needed, requiring puncture of the septum and routing through the mitral valve, which significantly increases complexity and risk of the procedure. Very few cardiologists are currently trained in performing a transseptal puncture, which is a challenging procedure by itself.
- Another drawback of the PVT device is its lack of fixation provision. It in effect uses its radial force to hold the stent in the desired position. For this to work, sufficient dilatation of the valve area has to be achieved; but this amount of dilation can cause damage to the annulus. Also, due to its inability to have an active fixation mechanism, the PVT device cannot be used to treat aortic regurgitation.
- Another drawback to this system is that it does not address the leakage of blood around the implant, after its implantation.
- Other prior art replacement heart valves use self-expanding stents that incorporate a valve. One such device is that disclosed in U.S. Pat. No. 7,018,406 to Seguin et al. and assigned to and made by CoreValve SA. In the endovascular aortic valve replacement procedure, accurate placement of aortic valves relative to coronary ostia and the mitral valve is critical. Standard self-expanding systems have very poor accuracy in deployment, however. Often the proximal end of the stent is not released from the delivery system until accurate placement is verified by fluoroscopy and the stent typically jumps once released. It is therefore often impossible to know where the ends of the stent will be with respect to the native valve, the coronary ostia, and the mitral valve. The anchoring mechanism is not actively provided (that is, there is no method of fixation other than the use of radial force and barbs that project into the surrounding tissue and not used as positioning marker (that is, markers seen under fluoroscopy to determine the position of the device).
- A simple barb as used in the CoreValve device relies mainly on friction for holding the position.
- Another drawback of prior art self-expanding replacement heart valve systems is their lack of radial strength. In order for self-expanding systems to be easily delivered through a delivery sheath, the metal needs to flex and bend inside the delivery catheter without being plastically deformed. In arterial stents, this is not a challenge, and there are many commercial arterial stent systems that apply adequate radial force against the vessel wall and yet can collapse to a small enough of a diameter to fit inside a delivery catheter without plastically deforming. However, when the stent has a valve fastened inside it, as is the case in aortic valve replacement, the anchoring of the stent to vessel walls is significantly challenged during diastole. The force required to hold back arterial pressure and prevent blood from going back inside the ventricle during diastole will be directly transferred to the stent/vessel wall interface. Therefore, the amount of radial force required to keep the self expanding stent/valve in contact with the vessel wall and prevent it from sliding will be much higher than in stents that do not have valves inside of them. Moreover, a self-expanding stent without sufficient radial force will end up dilating and contracting with each heartbeat, thereby distorting the valve, affecting its function and resulting in dynamic repositioning of the stent during delivery. Stent foreshortening or migration during expansion may lead to improper alignment.
- Additionally, the stent disclosed in U.S. Pat. No. 6,425,916 to Garrison simply crushes the native valve leaflets against the heart wall and does not engage the leaflets in a manner that would provide positive registration of the device relative to the native position of the valve. This increases an immediate risk of blocking the coronary ostia, as well as a longer-term risk of migration of the device post-implantation. Further still, the stent comprises openings or gaps in which the replacement valve is seated post-delivery. Tissue may protrude through these gaps, thereby increasing a risk of improper seating of the valve within the stent.
- In view of drawbacks associated with previously known techniques for endovascularly replacing a heart valve, it would be desirable to provide methods and apparatus that overcome those drawbacks.
- Sadra et al. (U.S. published application No. 20050137701) describes a mechanism for anchoring a heart valve, the anchoring mechanism having an actuation system operated remotely. This mechanism addresses the fixation issue; however, considering the irregular shape of the aortic annulus there is a real potential for deforming the prosthetic valve annulus; this may require additional balloon angioplasty to give it its final shape, and also make the new valve more prone to fatigue and fracture. Moreover, if full expansion of the stent is prone to deformation, the leaflet coaptation of the valve will be jeopardized.
- Sadra et al. (U.S. published application No. 20050137691) describes a system with two pieces, a valve piece and an anchor piece. The valve piece connects to the anchor piece in such a fashion that it will reduce the effective valve area considerably. Valve area, i.e., the inner diameter of the channel after the valve leaflets open, is of prime importance when considering an aortic valve replacement in a stenotic valve. Garrison's valve is also implanted in the inner portion of the stent, compromising the effective valve outflow area. Sadra et al.'s and Garrison's valves overlook this very critically important requirement.
- The technologies described above and other technologies (for example, those disclosed in U.S. Pat. No. 4,908,028 to Colon et al.; U.S. Published Application No. 2003/0014104, U.S. Published Application No. 2003/0109924, U.S. Published Application No. 2005/0251251, U.S. Published Application No. 2005/0203616, and U.S. Pat. No. 6,908,481 to Cribier; U.S. Pat. No. 5,607,469 to Frey; U.S. Pat. No. 6,723,123 to Kazatchkov et al.; Germany Patent No. DE 3,128,704 A1 to Kuepper; U.S. Pat. No. 3,312,237 to Mon et al.; U.S. Published Application No. 2005/0182483 to Osbourne et al.; U.S. Pat. No. 1,306,391 to Romanoff; U.S. Published Application No. 2005/0203618 to Sharkcawy et al.; U.S. Published Application No. 2006/0052802 to Sterman et al.; U.S. Pat. Nos. 5,713,952; and 5,876,437 to Vanney et al.) also use various biological, or other synthetic materials for fabrication of the prosthetic valve. The duration of function and physical deterioration of these new valves have not been addressed. Their changeability has not been addressed, in the percutaneous situation.
- It is to the solution of these and other problems that the present invention is directed.
- It is accordingly a primary object of the present invention to provide to methods and apparatus for endovascularly replacing a heart valve.
- In is another object of the present invention to provide methods and apparatus for endovascularly replacing a heart valve with a replacement valve prosthesis using a balloon expandable and/or self expanding valve cage stent upon which a bi-leaflet or tri-leaflet elastic valve is inserted.
- It is also a feature of this invention that the valve piece of the implant is removable, and thus exchangeable, in the event of long or medium term failure of the implanted valve.
- It is another object of this invention to provide maximal valve area to the out flow tract of the left ventricle, thus minimizing the gradient across the valve, by using a supra annular implant of the valve piece to the valve cage stent.
- These and other objects are achieved by a heart valve prosthesis comprising a cylindrical valve cage stent constructed to be implanted percutaneously in the planar axis of a native valve annulus, the valve cage stent having a superior rim; and an elastic and compressible, multi-leaflet valve insertable percutaneously into the body, the valve including a valve frame made from a memory metal and a tissue cover attached to the valve frame; and attachment means for attaching the valve to the superior rim of the valve cage.
- The valve can be a bi-leaflet or a tri-leaflet valve. The bi-leaflet valve includes a frame, a tissue cover, a deformable hinge, and means for detachably connecting the valve to the valve cage stent. The frame has two substantially semicircular, expandable, and compressible parts, and the tissue cover is configured to cover the two parts of the frame with the straight sides of the two parts in spaced-apart relation. The tissue cover has a central aperture and the two parts of the frame have respective slots. The deformable hinge has oppositely extending arms extending through the slots and a stem received through the aperture. The superior rim of the valve cage stent has a valve mount affixed thereto for receiving a mating part on the hinge, thereby defining the attachment means.
- The tri-leaflet valve includes a frame, a tissue cover, and means for detachably connecting the valve to the valve cage stent. The frame is cylindrical and has three commissural posts mounted thereon. The tissue cover has three cusps fitted and sewn to the valve frame, the commissural posts being sized to maintain the commissural height of the cusps. The valve cage stent has three commissural pins extending from the superior rim thereof, and the commissural posts of the frame are cannulated to receive the commissural pins of the valve cage stent, thereby defining the attachment means.
- Other objects, features and advantages of the present invention will be apparent to those skilled in the art upon a reading of this specification including the accompanying drawings.
- The invention is better understood by reading the following Detailed Description of the Preferred Embodiments with reference to the accompanying drawing figures, in which like reference numerals refer to like elements throughout, and in which:
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FIG. 1 is a diagram of a valve prosthesis in accordance with the present invention. -
FIG. 2A is a diagrammatic plan view of a frame for a bi-leaflet percutaneous heart valve in accordance with the present invention. -
FIG. 2B is a diagrammatic plan view of a tissue cover for the frame ofFIG. 2A . -
FIG. 2C is a diagrammatic plan view of an assembled bi-leaflet percutaneous heart valve in accordance with the present invention, incorporating the frame ofFIG. 2A and the tissue cover ofFIG. 2B . -
FIG. 2D is a diagrammatic side elevational view of the bi-leaflet percutaneous heart valve ofFIG. 2C in the open position. -
FIG. 2E is a diagrammatic side elevational view of the bi-leaflet percutaneous heart valve ofFIG. 2C in the closed position. -
FIG. 2F is a top perspective view of an assembled bi-leaflet percutaneous heart valve in accordance with the present invention, in the closed position. -
FIGS. 2G and 2H are top and side perspective views of the bi-leaflet percutaneous heart valve ofFIG. 2F in the open position. -
FIGS. 21 and 2J are side perspective views of the valve cage stent for use with the bi-leaflet percutaneous heart valve ofFIG. 2F . -
FIG. 2K is a partial perspective view of the bi-leaflet percutaneous heart valve ofFIG. 2F mounted on the valve cage stent ofFIG. 21 , with the valve in the closed position. -
FIG. 2L is a partial perspective view of the bi-leaflet percutaneous heart valve ofFIG. 2F mounted on he valve cage stent ofFIG. 21 , with the valve in the open position. -
FIG. 3A is a diagrammatic perspective view of a frame for a tri-leaflet percutaneous heart valve in accordance with the present invention. -
FIG. 3B is a perspective view of a tissue cover for the frame ofFIG. 3A . -
FIG. 3C is a perspective view of an assembled tri-leaflet percutaneous heart valve in accordance with the present invention, incorporating the frame ofFIG. 3A and the tissue cover ofFIG. 3B -
FIG. 3D is a side perspective view of the valve cage stent for use with the tri-leaflet percutaneous heart valve ofFIG. 3C . -
FIGS. 3E and 3F are top perspective views of the valve cage stent for use with the tri-leaflet percutaneous heart valve ofFIG. 3C . -
FIG. 3G is a diagrammatic view of a portion the valve cage stent for use with the tri-leaflet percutaneous heart valve ofFIG. 3C , which as been opened up and flattened for purposes of illustration. -
FIG. 3H is a partially cut-away perspective view of the tri-leaflet percutaneous heart valve ofFIG. 3C mounted on the valve cage stent ofFIG. 3D , in the undeployed condition. -
FIG. 3I is a partially cut-away perspective view of the tri-leaflet percutaneous heart valve ofFIG. 3C mounted on the valve cage stent ofFIG. 3D , in the deployed condition. -
FIGS. 4A-4G show the sequence of steps in implantation of the bi-leaflet percutaneous heart valve prosthesis ofFIG. 2C in an aorta, in which the valve is attached to the valve cage stent outside the delivery catheter. -
FIGS. 5A-5I are diagrammatic representations of the sequence of steps in implantation of the bi-leaflet percutaneous heart valve ofFIG. 2C , the aorta being omitted from all ofFIGS. 5A-5I and the valve cage being omitted fromFIGS. 5A-5F for clarity. -
FIGS. 6A-6J show the sequence of steps in implantation of the tri-leaflet percutaneous heart valve ofFIG. 3C in an aorta, in which the valve is attached to the valve cage stent outside the delivery catheter. -
FIGS. 7A and 7B are exploded and assembled views, respectively, of the delivery system apparatus used in implantation of the bi-leaflet and tri-leaflet valves in accordance with the present invention. -
FIG. 7C is an end view of the flexible sheath of the delivery system apparatus ofFIGS. 7A and 7B . -
FIG. 8 is a side view of a valve cage stent mounted on a balloon catheter. -
FIGS. 9A-9T show the sequence of steps in implantation of the tri-leaflet percutaneous heart valve ofFIG. 3C in an aorta, in which the valve is attached to the valve cage stent within the delivery catheter. - In describing preferred embodiments of the present invention illustrated in the drawings, specific terminology is employed for the sake of clarity. However, the invention is not intended to be limited to the specific terminology so selected, and it is to be understood that each specific element includes all technical equivalents that operate in a similar manner to accomplish a similar purpose.
- The present invention relates to heart valve prostheses that can be implanted percutaneously by means of a catheter from a remote location without opening the chest cavity. As shown in
FIG. 1 , thevalve prosthesis 10 comprises two parts, (1) avalve cage stent 20 constructed to be implanted in the planar axis of the native valve annulus, (2) an elastic andcompressible valve 30, and (3) an attachment mechanism for attaching thevalve 30 to the superior rim of the above mentionedvalve cage stent 20. In accordance with the present invention, two types 110 and 210 ofheart valve prosthesis 10 are contemplated, one type 110 incorporating an elastic and compressible bi-leaflet hinged valve 130 (shown inFIGS. 2A-2E ) and the other type 210 incorporating an elastic and compressible tri-leaflet biologic valve 230 (shown inFIGS. 3A-3C ). A system and method for implanting the valves (shown inFIGS. 4A-4G, 5A-5I, and 6A-6J ) is also encompassed by the invention. - Referring now to
FIGS. 2A-2H , thebi-leaflet tissue valve 130 comprises a two-part (that is, a two-leaflet)frame 132 made from a memory metal wire or strip and atissue cover 133. As best shown inFIG. 2A , eachpart frame 132 is substantially semicircular. Portions of eachpart FIGS. 2A and 2C ) so that eachpart frame 132, as well as theframe 132 as a whole, is expandable and compressible, while the remaining portions of theframe 132 are not expandable and compressible. - Each
part frame 132 includes aslot 134 for receiving ahinge 135 having a shape when deployed that is similar to a lower-case “t”, as shown inFIGS. 2D and 2E , having twoarms slot 134 is formed unitarily with theframe 132. The “t”-shapedhinge 135 is stamped out of memory metal (for example, nitinol) sheeting so that it is deformable. Thearms hinge 135 haveprojections 135 d at their ends, which function as stops for the leaflets. The stem 135 c of thehinge 135 has a snap-on or screw-inmechanism 141 for attachment to a valve mount 142 (shown inFIGS. 21-2L ), as described below. - The tissue cover 133 (shown in
FIG. 2B ) is made, for example, of equine or bovine pericardium, or various synthetic materials, for example, or medical grade silicone, fabric, or other compressible, materials, and is configured to cover the twoparts frame 132 with their straight sides in spaced apart relation, with acentral aperture 133 a in the center for receiving the stem 135 c of the “t”-shapedhinge 135 and twoside apertures 133 b in alignment with theslots 134 for receiving thearms hinge 135. Thetissue cover 133 is sewn to eachpart frame 132, as shown inFIGS. 2C and 2F-2H , and thus connects the twoparts frame 132 in spaced-apart relation. - As discussed in greater detail below, in use, the
bi-leaflet valve 130 is detachably connected to a valve mount 142 (shown inFIGS. 21 and 2L ) via the “t”-shapedhinge 135, as shown inFIGS. 2K-2N, 4D-4G, and 5G-5I . Thevalve mount 142 is also made from a memory metal so that it is collapsible. More specifically, thevalve mount 142 hasarms receptacle 142 c, which are folded up vertically when thevalve cage stent 120 is in its compressed (undeployed) condition, the ends of thearms valve cage stent 120. - The detachable and collapsible bi-leaflet construction of the
valve 130 enables thevalve 130 in conjunction with its entire delivery system to be sized down so that it can be inserted percutaneously using a catheter, as described below. - Referring now to
FIGS. 3A-3C , thetri-leaflet tissue valve 230 comprises an expandable and compressible valve frame 232 (shown inFIG. 3A ) made from a memory metal wire or strip and a tissue cover 233 (shown inFIGS. 3B and 3C ). Thetissue cover 233 is made from the individual cusps of a porcine aortic valve sewn to appropriate fabric. Three identical cusps are selected. Two or more pigs are used to get ideal sized aortic cusps. The muscle bar cusp is preferably not used; and all of the sinus and surrounding tissue is S discarded. The commissural height is maintained at all cost. The tissue cover 233 (that is, the cusps sewn to the fabric) is fitted and sewn to thevalve frame 232. Thevalve frame 232 has three cannulatedcommissural posts tissue cover 233 is sewn to thecommissural posts FIG. 3C ). - As shown in
FIGS. 3A-3C , thetri-leaflet valve 230 is mounted on commissural pins 240 aa, 240 bb, and 240 cc provided on avalve cage stent 220 of the type disclosed in provisional application No. 60/735,221, which is incorporated herein by reference in its entirety. More specifically, thecommissural posts valve frame 232 are cannulated to receive the commissural pins 240 aa, 240 bb, and 240 cc, respectively, of thevalve cage stent 220, thereby connecting the valve frame 232 (and thus the valve 230) to thevalve cage stent 220. As described below, the heart valve prosthesis 210 incorporating thetri-leaflet valve 230 is delivered using a catheter. - As shown in
FIG. 3G , thevalve cage stent 220 for use with thetri-leaflet valve 230 has threedifferent zones zone 221 functions as the stent connector, which is identical to the stent disclosed in Int'l Patent Application No. PCT/US2006/043526, filed Nov. 9, 2006 (which is based on U.S. Provisional Application No. 60/735,221), and which connects to the native valve annulus. The second andthird zones center zone 221, function respectively as the superior valve rim carrying the commissural pins in the tri-leaflet valve prosthesis 210 or the valve mount in the bi-leaflet valve prosthesis 110, and the inferior valve skirt. Thevalve skirt 223 provides additional support, as well as a fabric/tissue attachment area to minimize leaking. - The present invention also encompasses a system and method for implanting the above-described
percutaneous valve prostheses 10 in the body. In a first embodiment, the system comprises avalve cage stent 20 for implantation in the body by the use of a first catheter of a delivery system 500 (shown inFIGS. 8A and 8B , and as described in greater detail hereinafter) to provide a stable, fixed, and sturdy frame within which an elastic,compressible valve 30 can be inserted and secured by a second catheter (not shown), and thevalve 30 is attached to thevalve cage stent 20 after they are discharged from their respective catheters. Performing the procedure in two parts at the same session downsizes the devices considerably, so that the procedure can be performed percutaneously. In a second embodiment, the system comprises avalve cage stent 20 and an elastic,compressible valve 30 which are inserted using the same catheter, and thevalve 30 is attached to thevalve cage stent 20 within the catheter, as shown inFIGS. 9A-9T . - The
valve cage stent 20 is a self-expanding or balloon expandable cylindricalvalve cage stent 20, made from memory metal, or stainless steel respectively. The self-expanding valve cage stent and the balloon expandable valve cage stent are structurally the same (that is, they differ only in the material from which they are made). Thevalve cage stent 20 is fabricated from metal tubing (memory metal or stainless steel), so that it is cylindrical in shape, with the stent pattern being cut into the tubing by laser. - The expansion of the
valve cage stent 20 produces maximal foreshortening of the ovals in the mid portion of the stent and thus provides active fixation of the stent to the annulus of the valve being replaced. Thevalve cage stent 20 has a fabric covering on its interior and parts of its exterior surfaces so in its expanded state it forms a complete seal and does not allow any leakage of blood. - For delivery, the
valve cage stent 20 is mounted on a balloon 600 (FIG. 8 ), or in a restraining sheath if self-expandable. Thedelivery system apparatus 500 is shown inFIGS. 7A-7C . Thedelivery system apparatus 500 comprises a flexibleouter sheath 510, in which thevalve cage stent 20 is inserted with a first set ofguide wires 520 attached thereto, followed by a slottednosecone 530 having another set ofguide wires 540 attached thereto. - The
valve cage stent 20 has provisions for the attachment of the prosthetic valve, depending on the type of prosthetic valve contemplated to be used. For example, in the case of a bi-leaflet valve, the valve is attached to thevalve cage stent 120 via a valve mount affixed to thevalve cage stent 120, as shown inFIGS. 4D-4G and 5G-5I . In the case of a tri-leaflet valve, the valve is attached to thevalve cage stent 220 via engagement of the valvecommissural posts valve cage stent 220, as shown inFIGS. 6H-6J . - The delivery system employs a two stage procedure, both stages of which can be performed at the same session, only minutes apart. The first stage is insertion of the
valve cage stent 20. In the case of a bi-leaflet valve, as shown inFIG. 4A , thevalve cage stent 120 has a valve mount connected thereto and a guide wire connected to the valve mount. In the case of a tri-leaflet valve, as shown inFIGS. 6A-6G and as described above, thevalve cage stent 220 has three commissural pins 240 aa, 240 bb, and 240 cc provided thereon and guide wires connected thereto. - The second stage is insertion of the elastic and compressible valve, which is restrained in another catheter (not shown) for delivery into the
valve cage stent 20. As shown inFIGS. 4A-4D, 5A-5F, and 6A-6H , in the second stage, the valve is placed over the guide wire (in the case of a bi-leaflet valve) or guide wires (in the case of the tri-leaflet valve) connected to thevalve cage stent 20 in order to ensure proper positioning of the valve relative to the stent. Once the valve is seated, the guide wire or wires are withdrawn (FIGS. 4D-4G, 5G-5I, and 61-6J ). - Because the bi-leaflet valve is detachable from the valve mount, it can be replaced when necessary. The valve mount has a snap-on or screw-in mechanism for attachment of the “t”-shaped
hinge 135 thereto, as well as the above-described guide wire attached to it for placement of the valve. The use of avalve cage 20 allows for fabrication of a tri-leaflet tissue valve. - In addition, the connection of
valve 30 to thevalve cage stent 20 provides the best effective flow dynamics, the flexibility of thewhole system 500 is greatly increased, and the profile of thewhole system 500 is reduced so that it can be inserted through a small opening in the access vessel. - Modifications and variations of the above-described embodiments of the present invention are possible, as appreciated by those skilled in the art in light of the above teachings. It is therefore to be understood that, within the scope of the appended claims and their equivalents, the invention may be practiced otherwise than as specifically described.
Claims (20)
1. A two-part heart valve prosthesis, comprising:
a self-expanding valve cage stent including a series of struts configured to self-expand to a tubular expanded shape for engaging surrounding tissue; and
a bi-leaflet valve adapted for deployment within a lumen of the valve cage stent, the bi-leaflet valve formed by two leaflets supported by a compressible valve frame made from a memory metal, wherein the two leaflets are capable of rotating between open and closed positions for regulating blood flow through the lumen of the valve cage stent.
2. The prosthesis of claim 1 , wherein the leaflets are each defined by a semicircular frame part across which a tissue cover is secured.
3. The prosthesis of claim 2 , wherein the frame parts each defining a central slot aligned with a central aperture through a respective tissue cover, and the valve frame is connected to a pair of hinge arms that curve radially outward and pass through the slot and aperture in each leaflet so that the leaflets are hinged to move between the open and closed positions.
4. The prosthesis of claim 2 , wherein the tissue covers on the leaflets are connected to each other in a circular cover member having a central aperture through which a central stem of the valve frame passes, the central stem being fixed with respect to the valve cage stent, and the hinge arms are fixed with respect to the central stem.
5. The prosthesis of claim 2 , comprising a fabric cover over each tissue cover to provide additional support and minimize leaking.
6. The prosthesis of claim 1 , wherein the valve cage stent includes a valve mount suspended within the central lumen and connected to the expanded struts, and the valve frame attaches to the valve mount.
7. The prosthesis of claim 6 , wherein the valve frame has a central stem with a snap-on or screw-in mechanism configured to be received in a valve receptacle defined by the valve mount.
8. The prosthesis of claim 6 , wherein the valve mount is suspended across a superior rim of the valve cage stent such that the tissue valve is coupled to a superior end of the valve cage stent.
9. The prosthesis of claim 8 , wherein the valve mount is suspended by a pair of radial arms extending across the central lumen.
10. The prosthesis of claim 1 , further including a guide wire attached to the valve mount to assist in coupling the central stem of the valve frame to the valve mount.
11. A two-part heart valve prosthesis, comprising:
a self-expanding valve cage stent including a series of struts configured to self-expand to a tubular expanded shape and engage surrounding tissue, and a valve mount suspended by radial arms at a central axis of a lumen defined by the expanded struts; and
a bi-leaflet tissue valve adapted to connect to the valve mount and comprising an expandable and compressible valve frame made from a memory metal with a pair of leaflets each defined by a semicircular frame part across which a tissue cover is secured, wherein the two leaflets are capable of rotating between open and closed positions for regulating blood flow through the lumen of the valve cage stent.
12. The prosthesis of claim 11 , wherein the valve frame has a central stem with a snap-on or screw-in mechanism configured to be received in the valve mount.
13. The prosthesis of claim 12 , wherein the tissue covers on the leaflets are connected to each other in a circular cover member having a central aperture through which the central stem passes.
14. The prosthesis of claim 12 , wherein the valve frame connects to a pair of hinge arms that curve radially outward and pass through central points on the leaflets so that the leaflets are hinged to move between the open and closed positions.
15. The prosthesis of claim 14 , wherein the frame parts each define a central slot aligned with a central aperture through a respective tissue cover, and the hinge arms pass through the slots and apertures in the leaflets.
16. The prosthesis of claim 15 , wherein the frame parts each have a strut extending from a straight segment thereof and terminating in a circular eyelet that defines the central slot.
17. The prosthesis of claim 11 , wherein the tissue covers are bovine pericardium.
18. The prosthesis of claim 17 , comprising a fabric cover over each tissue cover to provide additional support and minimize leaking.
19. The prosthesis of claim 11 , wherein the tissue covers are sewn to the frame parts.
20. The prosthesis of claim 11 , wherein the valve cage stent further comprises fabric along at least a portion of an interior surface and an exterior surface.
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US17/494,770 US20220023039A1 (en) | 2006-07-28 | 2021-10-05 | Two-part bi-leaflet heart valve prostheses |
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US30968009A | 2009-08-20 | 2009-08-20 | |
US15/221,435 US10350065B2 (en) | 2006-07-28 | 2016-07-27 | Percutaneous valve prosthesis and system and method for implanting the same |
US16/503,179 US11141265B2 (en) | 2006-07-28 | 2019-07-03 | Percutaneous valve prosthesis and system and method for implanting the same |
US17/494,770 US20220023039A1 (en) | 2006-07-28 | 2021-10-05 | Two-part bi-leaflet heart valve prostheses |
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US16/503,179 Active 2027-08-22 US11141265B2 (en) | 2006-07-28 | 2019-07-03 | Percutaneous valve prosthesis and system and method for implanting the same |
US17/494,770 Pending US20220023039A1 (en) | 2006-07-28 | 2021-10-05 | Two-part bi-leaflet heart valve prostheses |
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US16/503,179 Active 2027-08-22 US11141265B2 (en) | 2006-07-28 | 2019-07-03 | Percutaneous valve prosthesis and system and method for implanting the same |
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Families Citing this family (139)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2462509A1 (en) | 2001-10-04 | 2003-04-10 | Neovasc Medical Ltd. | Flow reducing implant |
IL158960A0 (en) | 2003-11-19 | 2004-05-12 | Neovasc Medical Ltd | Vascular implant |
WO2007058857A2 (en) | 2005-11-10 | 2007-05-24 | Arshad Quadri | Balloon-expandable, self-expanding, vascular prosthesis connecting stent |
WO2008013915A2 (en) | 2006-07-28 | 2008-01-31 | Arshad Quadri | Percutaneous valve prosthesis and system and method for implanting same |
US9585743B2 (en) | 2006-07-31 | 2017-03-07 | Edwards Lifesciences Cardiaq Llc | Surgical implant devices and methods for their manufacture and use |
US9408607B2 (en) | 2009-07-02 | 2016-08-09 | Edwards Lifesciences Cardiaq Llc | Surgical implant devices and methods for their manufacture and use |
US8252036B2 (en) | 2006-07-31 | 2012-08-28 | Syntheon Cardiology, Llc | Sealable endovascular implants and methods for their use |
US9566178B2 (en) | 2010-06-24 | 2017-02-14 | Edwards Lifesciences Cardiaq Llc | Actively controllable stent, stent graft, heart valve and method of controlling same |
US9814611B2 (en) | 2007-07-31 | 2017-11-14 | Edwards Lifesciences Cardiaq Llc | Actively controllable stent, stent graft, heart valve and method of controlling same |
DK3967274T3 (en) * | 2008-04-23 | 2022-10-03 | Medtronic Inc | HEART VALVE DEVICES WITH STENT |
MX2010011389A (en) * | 2008-04-23 | 2011-01-14 | Medtronic Inc | Stented heart valve devices. |
AU2009295960A1 (en) * | 2008-09-29 | 2010-04-01 | Cardiaq Valve Technologies, Inc. | Heart valve |
EP2341871B1 (en) * | 2008-10-01 | 2017-03-22 | Edwards Lifesciences CardiAQ LLC | Delivery system for vascular implant |
US9402720B2 (en) | 2009-01-12 | 2016-08-02 | Valve Medical Ltd. | Modular percutaneous valve structure and delivery method |
EP2419050B2 (en) | 2009-04-15 | 2023-10-18 | Edwards Lifesciences CardiAQ LLC | Vascular implant and delivery system |
US9730790B2 (en) | 2009-09-29 | 2017-08-15 | Edwards Lifesciences Cardiaq Llc | Replacement valve and method |
US8870950B2 (en) | 2009-12-08 | 2014-10-28 | Mitral Tech Ltd. | Rotation-based anchoring of an implant |
WO2011111047A2 (en) | 2010-03-10 | 2011-09-15 | Mitraltech Ltd. | Prosthetic mitral valve with tissue anchors |
US8579964B2 (en) | 2010-05-05 | 2013-11-12 | Neovasc Inc. | Transcatheter mitral valve prosthesis |
EP3061422B1 (en) | 2010-06-21 | 2021-11-03 | Edwards Lifesciences CardiAQ LLC | Replacement heart valve |
US9375312B2 (en) | 2010-07-09 | 2016-06-28 | Highlife Sas | Transcatheter atrio-ventricular valve prosthesis |
US9132009B2 (en) | 2010-07-21 | 2015-09-15 | Mitraltech Ltd. | Guide wires with commissural anchors to advance a prosthetic valve |
US8992604B2 (en) | 2010-07-21 | 2015-03-31 | Mitraltech Ltd. | Techniques for percutaneous mitral valve replacement and sealing |
US11653910B2 (en) | 2010-07-21 | 2023-05-23 | Cardiovalve Ltd. | Helical anchor implantation |
US9763657B2 (en) | 2010-07-21 | 2017-09-19 | Mitraltech Ltd. | Techniques for percutaneous mitral valve replacement and sealing |
US9579193B2 (en) | 2010-09-23 | 2017-02-28 | Transmural Systems Llc | Methods and systems for delivering prostheses using rail techniques |
US10321998B2 (en) | 2010-09-23 | 2019-06-18 | Transmural Systems Llc | Methods and systems for delivering prostheses using rail techniques |
EP3001978B2 (en) | 2010-09-23 | 2023-03-01 | Edwards Lifesciences CardiAQ LLC | Replacement heart valve delivery device |
CA2822381C (en) | 2010-12-23 | 2019-04-02 | Foundry Newco Xii, Inc. | System for mitral valve repair and replacement |
EP2688516B1 (en) | 2011-03-21 | 2022-08-17 | Cephea Valve Technologies, Inc. | Disk-based valve apparatus |
US9308087B2 (en) | 2011-04-28 | 2016-04-12 | Neovasc Tiara Inc. | Sequentially deployed transcatheter mitral valve prosthesis |
US9554897B2 (en) | 2011-04-28 | 2017-01-31 | Neovasc Tiara Inc. | Methods and apparatus for engaging a valve prosthesis with tissue |
WO2012177942A2 (en) | 2011-06-21 | 2012-12-27 | Hanson Gifford, Iii | Prosthetic heart valve devices and associated systems and methods |
EP2739214B1 (en) | 2011-08-05 | 2018-10-10 | Cardiovalve Ltd | Percutaneous mitral valve replacement and sealing |
US8852272B2 (en) | 2011-08-05 | 2014-10-07 | Mitraltech Ltd. | Techniques for percutaneous mitral valve replacement and sealing |
WO2013021374A2 (en) | 2011-08-05 | 2013-02-14 | Mitraltech Ltd. | Techniques for percutaneous mitral valve replacement and sealing |
US20140324164A1 (en) | 2011-08-05 | 2014-10-30 | Mitraltech Ltd. | Techniques for percutaneous mitral valve replacement and sealing |
US9549817B2 (en) | 2011-09-22 | 2017-01-24 | Transmural Systems Llc | Devices, systems and methods for repairing lumenal systems |
CN111000663B (en) | 2011-10-19 | 2022-04-15 | 托尔福公司 | Prosthetic heart valve devices, prosthetic mitral valves, and related systems and methods |
US9655722B2 (en) | 2011-10-19 | 2017-05-23 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
CA2848334C (en) | 2011-10-19 | 2020-10-20 | Twelve, Inc. | Devices, systems and methods for heart valve replacement |
US9039757B2 (en) | 2011-10-19 | 2015-05-26 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
US11202704B2 (en) | 2011-10-19 | 2021-12-21 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
US9763780B2 (en) | 2011-10-19 | 2017-09-19 | Twelve, Inc. | Devices, systems and methods for heart valve replacement |
US9827093B2 (en) | 2011-10-21 | 2017-11-28 | Edwards Lifesciences Cardiaq Llc | Actively controllable stent, stent graft, heart valve and method of controlling same |
US9579198B2 (en) | 2012-03-01 | 2017-02-28 | Twelve, Inc. | Hydraulic delivery systems for prosthetic heart valve devices and associated methods |
US9345573B2 (en) | 2012-05-30 | 2016-05-24 | Neovasc Tiara Inc. | Methods and apparatus for loading a prosthesis onto a delivery system |
US8628571B1 (en) | 2012-11-13 | 2014-01-14 | Mitraltech Ltd. | Percutaneously-deliverable mechanical valve |
US20150351906A1 (en) | 2013-01-24 | 2015-12-10 | Mitraltech Ltd. | Ventricularly-anchored prosthetic valves |
US10583002B2 (en) | 2013-03-11 | 2020-03-10 | Neovasc Tiara Inc. | Prosthetic valve with anti-pivoting mechanism |
US20140277427A1 (en) | 2013-03-14 | 2014-09-18 | Cardiaq Valve Technologies, Inc. | Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery |
US9730791B2 (en) | 2013-03-14 | 2017-08-15 | Edwards Lifesciences Cardiaq Llc | Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery |
US9681951B2 (en) | 2013-03-14 | 2017-06-20 | Edwards Lifesciences Cardiaq Llc | Prosthesis with outer skirt and anchors |
US9572665B2 (en) | 2013-04-04 | 2017-02-21 | Neovasc Tiara Inc. | Methods and apparatus for delivering a prosthetic valve to a beating heart |
CN105246431B (en) | 2013-05-20 | 2018-04-06 | 托尔福公司 | Implantable cardiac valve device, mitral valve repair device and related system and method |
US9561103B2 (en) | 2013-07-17 | 2017-02-07 | Cephea Valve Technologies, Inc. | System and method for cardiac valve repair and replacement |
WO2015013666A1 (en) | 2013-07-26 | 2015-01-29 | Cardiaq Valve Technologies, Inc. | Systems and methods for sealing openings in an anatomical wall |
US9901444B2 (en) * | 2013-12-17 | 2018-02-27 | Edwards Lifesciences Corporation | Inverted valve structure |
CA2938614C (en) | 2014-02-21 | 2024-01-23 | Edwards Lifesciences Cardiaq Llc | Delivery device for controlled deployement of a replacement valve |
USD755384S1 (en) | 2014-03-05 | 2016-05-03 | Edwards Lifesciences Cardiaq Llc | Stent |
US20170014115A1 (en) | 2014-03-27 | 2017-01-19 | Transmural Systems Llc | Devices and methods for closure of transvascular or transcameral access ports |
EP3128952A1 (en) | 2014-05-19 | 2017-02-15 | Edwards Lifesciences CardiAQ LLC | Replacement mitral valve with annular flap |
US9532870B2 (en) | 2014-06-06 | 2017-01-03 | Edwards Lifesciences Corporation | Prosthetic valve for replacing a mitral valve |
US10524910B2 (en) | 2014-07-30 | 2020-01-07 | Mitraltech Ltd. 3 Ariel Sharon Avenue | Articulatable prosthetic valve |
US10869755B2 (en) | 2014-12-09 | 2020-12-22 | Cephea Valve Technologies, Inc. | Replacement cardiac valves and methods of use and manufacture |
CA2973940C (en) | 2015-02-05 | 2022-08-23 | Mitraltech Ltd. | Prosthetic valve with axially-sliding frames |
US9974651B2 (en) | 2015-02-05 | 2018-05-22 | Mitral Tech Ltd. | Prosthetic valve with axially-sliding frames |
US10441416B2 (en) | 2015-04-21 | 2019-10-15 | Edwards Lifesciences Corporation | Percutaneous mitral valve replacement device |
US10376363B2 (en) | 2015-04-30 | 2019-08-13 | Edwards Lifesciences Cardiaq Llc | Replacement mitral valve, delivery system for replacement mitral valve and methods of use |
US10849746B2 (en) | 2015-05-14 | 2020-12-01 | Cephea Valve Technologies, Inc. | Cardiac valve delivery devices and systems |
WO2018136959A1 (en) | 2017-01-23 | 2018-07-26 | Cephea Valve Technologies, Inc. | Replacement mitral valves |
EP4335415A2 (en) | 2015-05-14 | 2024-03-13 | Cephea Valve Technologies, Inc. | Replacement mitral valves |
WO2016209970A1 (en) | 2015-06-22 | 2016-12-29 | Edwards Lifescience Cardiaq Llc | Actively controllable heart valve implant and methods of controlling same |
US10092400B2 (en) | 2015-06-23 | 2018-10-09 | Edwards Lifesciences Cardiaq Llc | Systems and methods for anchoring and sealing a prosthetic heart valve |
WO2017035002A1 (en) | 2015-08-21 | 2017-03-02 | Twelve Inc. | Implantable heart valve devices, mitral valve repair devices and associated systems and methods |
US10575951B2 (en) | 2015-08-26 | 2020-03-03 | Edwards Lifesciences Cardiaq Llc | Delivery device and methods of use for transapical delivery of replacement mitral valve |
US10117744B2 (en) | 2015-08-26 | 2018-11-06 | Edwards Lifesciences Cardiaq Llc | Replacement heart valves and methods of delivery |
US10350066B2 (en) | 2015-08-28 | 2019-07-16 | Edwards Lifesciences Cardiaq Llc | Steerable delivery system for replacement mitral valve and methods of use |
US10426482B2 (en) | 2015-09-15 | 2019-10-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Devices and methods for effectuating percutaneous Glenn and Fontan procedures |
US10531866B2 (en) | 2016-02-16 | 2020-01-14 | Cardiovalve Ltd. | Techniques for providing a replacement valve and transseptal communication |
USD815744S1 (en) | 2016-04-28 | 2018-04-17 | Edwards Lifesciences Cardiaq Llc | Valve frame for a delivery system |
CN109069272A (en) | 2016-04-29 | 2018-12-21 | 美敦力瓦斯科尔勒公司 | Prosthetic heart valve equipment and associated system and method with the anchor log with tether |
WO2017218877A1 (en) | 2016-06-17 | 2017-12-21 | Cephea Valve Technologies, Inc. | Cardiac valve delivery devices and systems |
US10350062B2 (en) | 2016-07-21 | 2019-07-16 | Edwards Lifesciences Corporation | Replacement heart valve prosthesis |
WO2018029680A1 (en) | 2016-08-10 | 2018-02-15 | Mitraltech Ltd. | Prosthetic valve with concentric frames |
USD800908S1 (en) | 2016-08-10 | 2017-10-24 | Mitraltech Ltd. | Prosthetic valve element |
CA3033666A1 (en) | 2016-08-19 | 2018-02-22 | Edwards Lifesciences Corporation | Steerable delivery system for replacement mitral valve and methods of use |
US20180055477A1 (en) * | 2016-08-23 | 2018-03-01 | Tyco Electronics Corporation | Transcatheter Aortic Valve Implantation Assembly with Integrated Imager |
CA3034006A1 (en) | 2016-08-26 | 2018-03-01 | Edwards Lifesciences Corporation | Multi-portion replacement heart valve prosthesis |
US10758348B2 (en) | 2016-11-02 | 2020-09-01 | Edwards Lifesciences Corporation | Supra and sub-annular mitral valve delivery system |
US10653523B2 (en) | 2017-01-19 | 2020-05-19 | 4C Medical Technologies, Inc. | Systems, methods and devices for delivery systems, methods and devices for implanting prosthetic heart valves |
US10433993B2 (en) * | 2017-01-20 | 2019-10-08 | Medtronic Vascular, Inc. | Valve prosthesis having a radially-expandable sleeve integrated thereon for delivery and prevention of paravalvular leakage |
AU2018203053B2 (en) | 2017-01-23 | 2020-03-05 | Cephea Valve Technologies, Inc. | Replacement mitral valves |
US10561495B2 (en) | 2017-01-24 | 2020-02-18 | 4C Medical Technologies, Inc. | Systems, methods and devices for two-step delivery and implantation of prosthetic heart valve |
US10433961B2 (en) | 2017-04-18 | 2019-10-08 | Twelve, Inc. | Delivery systems with tethers for prosthetic heart valve devices and associated methods |
US10702378B2 (en) | 2017-04-18 | 2020-07-07 | Twelve, Inc. | Prosthetic heart valve device and associated systems and methods |
US10575950B2 (en) | 2017-04-18 | 2020-03-03 | Twelve, Inc. | Hydraulic systems for delivering prosthetic heart valve devices and associated methods |
US10792151B2 (en) | 2017-05-11 | 2020-10-06 | Twelve, Inc. | Delivery systems for delivering prosthetic heart valve devices and associated methods |
US10646338B2 (en) | 2017-06-02 | 2020-05-12 | Twelve, Inc. | Delivery systems with telescoping capsules for deploying prosthetic heart valve devices and associated methods |
US10709591B2 (en) | 2017-06-06 | 2020-07-14 | Twelve, Inc. | Crimping device and method for loading stents and prosthetic heart valves |
US10729541B2 (en) | 2017-07-06 | 2020-08-04 | Twelve, Inc. | Prosthetic heart valve devices and associated systems and methods |
EP3648708A4 (en) | 2017-07-06 | 2021-03-31 | Edwards Lifesciences Corporation | Steerable delivery system and components |
US10786352B2 (en) | 2017-07-06 | 2020-09-29 | Twelve, Inc. | Prosthetic heart valve devices and associated systems and methods |
US10575948B2 (en) | 2017-08-03 | 2020-03-03 | Cardiovalve Ltd. | Prosthetic heart valve |
US11793633B2 (en) | 2017-08-03 | 2023-10-24 | Cardiovalve Ltd. | Prosthetic heart valve |
US10537426B2 (en) | 2017-08-03 | 2020-01-21 | Cardiovalve Ltd. | Prosthetic heart valve |
US11246704B2 (en) | 2017-08-03 | 2022-02-15 | Cardiovalve Ltd. | Prosthetic heart valve |
US10888421B2 (en) | 2017-09-19 | 2021-01-12 | Cardiovalve Ltd. | Prosthetic heart valve with pouch |
JP7393005B2 (en) | 2017-10-19 | 2023-12-06 | アンテリス テクノロジーズ コーポレイション | Replacement heart valve with fewer sutures |
GB201720803D0 (en) | 2017-12-13 | 2018-01-24 | Mitraltech Ltd | Prosthetic Valve and delivery tool therefor |
GB201800399D0 (en) | 2018-01-10 | 2018-02-21 | Mitraltech Ltd | Temperature-control during crimping of an implant |
CN111818877B (en) | 2018-01-25 | 2023-12-22 | 爱德华兹生命科学公司 | Delivery system for assisting in recapture and repositioning of replacement valves after deployment |
US11051934B2 (en) | 2018-02-28 | 2021-07-06 | Edwards Lifesciences Corporation | Prosthetic mitral valve with improved anchors and seal |
WO2019195860A2 (en) | 2018-04-04 | 2019-10-10 | Vdyne, Llc | Devices and methods for anchoring transcatheter heart valve |
AU2019269740B2 (en) | 2018-05-18 | 2023-11-23 | Anteris Technologies Corporation | Inverted heart valve for transcatheter valve replacement |
EP3793481A4 (en) | 2018-05-18 | 2022-03-09 | Anteris Technologies Corporation | Heart valve with gathered sealing region |
WO2019222756A1 (en) | 2018-05-18 | 2019-11-21 | Admedus Corporation | Replacement heart valve assembly with a valve loaded distally from a stent |
US11857441B2 (en) | 2018-09-04 | 2024-01-02 | 4C Medical Technologies, Inc. | Stent loading device |
US11278437B2 (en) | 2018-12-08 | 2022-03-22 | Vdyne, Inc. | Compression capable annular frames for side delivery of transcatheter heart valve replacement |
US10595994B1 (en) | 2018-09-20 | 2020-03-24 | Vdyne, Llc | Side-delivered transcatheter heart valve replacement |
US11344413B2 (en) | 2018-09-20 | 2022-05-31 | Vdyne, Inc. | Transcatheter deliverable prosthetic heart valves and methods of delivery |
US11071627B2 (en) | 2018-10-18 | 2021-07-27 | Vdyne, Inc. | Orthogonally delivered transcatheter heart valve frame for valve in valve prosthesis |
US10321995B1 (en) | 2018-09-20 | 2019-06-18 | Vdyne, Llc | Orthogonally delivered transcatheter heart valve replacement |
US11109969B2 (en) | 2018-10-22 | 2021-09-07 | Vdyne, Inc. | Guidewire delivery of transcatheter heart valve |
US11253359B2 (en) | 2018-12-20 | 2022-02-22 | Vdyne, Inc. | Proximal tab for side-delivered transcatheter heart valves and methods of delivery |
CN113891686A (en) | 2019-01-23 | 2022-01-04 | 内奥瓦斯克医疗有限公司 | Flow-altering device with cover |
US11185409B2 (en) | 2019-01-26 | 2021-11-30 | Vdyne, Inc. | Collapsible inner flow control component for side-delivered transcatheter heart valve prosthesis |
US11273032B2 (en) | 2019-01-26 | 2022-03-15 | Vdyne, Inc. | Collapsible inner flow control component for side-deliverable transcatheter heart valve prosthesis |
CN113543750A (en) | 2019-03-05 | 2021-10-22 | 维迪内股份有限公司 | Tricuspid valve regurgitation control apparatus for orthogonal transcatheter heart valve prosthesis |
US11076956B2 (en) | 2019-03-14 | 2021-08-03 | Vdyne, Inc. | Proximal, distal, and anterior anchoring tabs for side-delivered transcatheter mitral valve prosthesis |
US11173027B2 (en) | 2019-03-14 | 2021-11-16 | Vdyne, Inc. | Side-deliverable transcatheter prosthetic valves and methods for delivering and anchoring the same |
AU2020267390A1 (en) | 2019-05-04 | 2021-11-11 | Vdyne, Inc. | Cinch device and method for deployment of a side-delivered prosthetic heart valve in a native annulus |
WO2020236931A1 (en) | 2019-05-20 | 2020-11-26 | Neovasc Tiara Inc. | Introducer with hemostasis mechanism |
WO2021035032A1 (en) | 2019-08-20 | 2021-02-25 | Vdyne, Inc. | Delivery and retrieval devices and methods for side-deliverable transcatheter prosthetic valves |
AU2020337235A1 (en) | 2019-08-26 | 2022-03-24 | Vdyne, Inc. | Side-deliverable transcatheter prosthetic valves and methods for delivering and anchoring the same |
US11234813B2 (en) | 2020-01-17 | 2022-02-01 | Vdyne, Inc. | Ventricular stability elements for side-deliverable prosthetic heart valves and methods of delivery |
US11931253B2 (en) | 2020-01-31 | 2024-03-19 | 4C Medical Technologies, Inc. | Prosthetic heart valve delivery system: ball-slide attachment |
US20230248513A1 (en) | 2020-07-07 | 2023-08-10 | Anteris Technologies Corporation | Expandable frame for improved hemodynamic performance of transcatheter replacement heart valve |
US11622853B1 (en) | 2022-09-30 | 2023-04-11 | Anteris Technologies Corporation | Prosthetic heart valves |
Family Cites Families (296)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1306391A (en) * | 1918-02-09 | 1919-06-10 | Hippolyte Romanoff | Valve. |
US3312237A (en) * | 1964-05-06 | 1967-04-04 | Mon George | Bicuspid heart valve |
GB1264471A (en) | 1968-01-12 | 1972-02-23 | ||
US3739402A (en) | 1970-10-15 | 1973-06-19 | Cutter Lab | Bicuspid fascia lata valve |
AR206762A1 (en) | 1976-01-01 | 1976-08-13 | Pisanu A | LOW PROFILE BIOPROTHESIS DERIVED FROM PORCINE HETEROLOGICAL AORTIC VALVE |
US4340977A (en) | 1980-09-19 | 1982-07-27 | Brownlee Richard T | Catenary mitral valve replacement |
US4339831A (en) | 1981-03-27 | 1982-07-20 | Medtronic, Inc. | Dynamic annulus heart valve and reconstruction ring |
US4470157A (en) | 1981-04-27 | 1984-09-11 | Love Jack W | Tricuspid prosthetic tissue heart valve |
US4865600A (en) | 1981-08-25 | 1989-09-12 | Baxter International Inc. | Mitral valve holder |
EP0088118A1 (en) | 1981-09-16 | 1983-09-14 | WALLSTEN, Hans Ivar | Device for application in blood vessels or other difficultly accessible locations |
US4777951A (en) | 1986-09-19 | 1988-10-18 | Mansfield Scientific, Inc. | Procedure and catheter instrument for treating patients for aortic stenosis |
FR2612597B1 (en) * | 1987-03-20 | 1989-06-23 | Colon Jean | VALVE HAS AT LEAST ONE TILT SHUTTER IN RELATION TO ELASTIC PIVOTS |
US4994077A (en) | 1989-04-21 | 1991-02-19 | Dobben Richard L | Artificial heart valve for implantation in a blood vessel |
DK124690D0 (en) * | 1990-05-18 | 1990-05-18 | Henning Rud Andersen | FAT PROTECTION FOR IMPLEMENTATION IN THE BODY FOR REPLACEMENT OF NATURAL FLEET AND CATS FOR USE IN IMPLEMENTING A SUCH FAT PROTECTION |
US5411552A (en) * | 1990-05-18 | 1995-05-02 | Andersen; Henning R. | Valve prothesis for implantation in the body and a catheter for implanting such valve prothesis |
GB9012716D0 (en) | 1990-06-07 | 1990-08-01 | Frater Robert W M | Mitral heart valve replacements |
US5163955A (en) | 1991-01-24 | 1992-11-17 | Autogenics | Rapid assembly, concentric mating stent, tissue heart valve with enhanced clamping and tissue alignment |
US5795325A (en) | 1991-07-16 | 1998-08-18 | Heartport, Inc. | Methods and apparatus for anchoring an occluding member |
US5370685A (en) | 1991-07-16 | 1994-12-06 | Stanford Surgical Technologies, Inc. | Endovascular aortic valve replacement |
US6283127B1 (en) * | 1992-12-03 | 2001-09-04 | Wesley D. Sterman | Devices and methods for intracardiac procedures |
DE4336899C1 (en) * | 1993-10-28 | 1994-12-01 | Novacor Gmbh | Double-leaf heart valve prosthesis |
US5509930A (en) * | 1993-12-17 | 1996-04-23 | Autogenics | Stentless heart valve |
US5522885A (en) | 1994-05-05 | 1996-06-04 | Autogenics | Assembly tooling for an autologous tissue heart valve |
US5554185A (en) | 1994-07-18 | 1996-09-10 | Block; Peter C. | Inflatable prosthetic cardiovascular valve for percutaneous transluminal implantation of same |
US5397355A (en) * | 1994-07-19 | 1995-03-14 | Stentco, Inc. | Intraluminal stent |
US5713952A (en) * | 1995-09-11 | 1998-02-03 | St. Jude Medical, Inc. | Apparatus for attachment of heart valve holder to heart valve prosthesis |
AU7458596A (en) * | 1995-10-20 | 1997-05-07 | Bandula Wijay | Vascular stent |
US6428489B1 (en) | 1995-12-07 | 2002-08-06 | Precision Vascular Systems, Inc. | Guidewire system |
US5879381A (en) * | 1996-03-10 | 1999-03-09 | Terumo Kabushiki Kaisha | Expandable stent for implanting in a body |
US5855601A (en) * | 1996-06-21 | 1999-01-05 | The Trustees Of Columbia University In The City Of New York | Artificial heart valve and method and device for implanting the same |
DE19625202A1 (en) | 1996-06-24 | 1998-01-02 | Adiam Medizintechnik Gmbh & Co | Prosthetic mitral heart valve |
DE19624948A1 (en) | 1996-06-24 | 1998-01-02 | Adiam Medizintechnik Gmbh & Co | Prosthetic heart valve |
US6015431A (en) * | 1996-12-23 | 2000-01-18 | Prograft Medical, Inc. | Endolumenal stent-graft with leak-resistant seal |
EP0850607A1 (en) | 1996-12-31 | 1998-07-01 | Cordis Corporation | Valve prosthesis for implantation in body channels |
US6168616B1 (en) * | 1997-06-02 | 2001-01-02 | Global Vascular Concepts | Manually expandable stent |
US5935108A (en) * | 1997-11-14 | 1999-08-10 | Reflow, Inc. | Recanalization apparatus and devices for use therein and method |
US6746422B1 (en) | 2000-08-23 | 2004-06-08 | Norborn Medical, Inc. | Steerable support system with external ribs/slots that taper |
US20040254635A1 (en) * | 1998-03-30 | 2004-12-16 | Shanley John F. | Expandable medical device for delivery of beneficial agent |
US6520983B1 (en) * | 1998-03-31 | 2003-02-18 | Scimed Life Systems, Inc. | Stent delivery system |
US6733523B2 (en) * | 1998-12-11 | 2004-05-11 | Endologix, Inc. | Implantable vascular graft |
US7018401B1 (en) * | 1999-02-01 | 2006-03-28 | Board Of Regents, The University Of Texas System | Woven intravascular devices and methods for making the same and apparatus for delivery of the same |
US6425916B1 (en) * | 1999-02-10 | 2002-07-30 | Michi E. Garrison | Methods and devices for implanting cardiac valves |
US8216256B2 (en) * | 1999-04-09 | 2012-07-10 | Evalve, Inc. | Detachment mechanism for implantable fixation devices |
WO2000064380A1 (en) | 1999-04-23 | 2000-11-02 | St. Jude Medical Cardiovascular Group, Inc. | Artificial heart valve attachment apparatus |
US6790229B1 (en) | 1999-05-25 | 2004-09-14 | Eric Berreklouw | Fixing device, in particular for fixing to vascular wall tissue |
US6749560B1 (en) | 1999-10-26 | 2004-06-15 | Circon Corporation | Endoscope shaft with slotted tube |
AU1068800A (en) * | 1999-11-10 | 2001-06-06 | Impsa International Incorporated | Prosthetic heart valve |
US8016877B2 (en) * | 1999-11-17 | 2011-09-13 | Medtronic Corevalve Llc | Prosthetic valve for transluminal delivery |
US20070043435A1 (en) | 1999-11-17 | 2007-02-22 | Jacques Seguin | Non-cylindrical prosthetic valve system for transluminal delivery |
US8579966B2 (en) | 1999-11-17 | 2013-11-12 | Medtronic Corevalve Llc | Prosthetic valve for transluminal delivery |
US7018406B2 (en) * | 1999-11-17 | 2006-03-28 | Corevalve Sa | Prosthetic valve for transluminal delivery |
US6458153B1 (en) | 1999-12-31 | 2002-10-01 | Abps Venture One, Ltd. | Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof |
PL211544B1 (en) | 2000-01-31 | 2012-05-31 | Cook Biotech Inc | Heart valve device containing set of valve stent |
DE10010074B4 (en) | 2000-02-28 | 2005-04-14 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Device for fastening and anchoring heart valve prostheses |
US6454799B1 (en) * | 2000-04-06 | 2002-09-24 | Edwards Lifesciences Corporation | Minimally-invasive heart valves and methods of use |
US6517573B1 (en) * | 2000-04-11 | 2003-02-11 | Endovascular Technologies, Inc. | Hook for attaching to a corporeal lumen and method of manufacturing |
US6729356B1 (en) | 2000-04-27 | 2004-05-04 | Endovascular Technologies, Inc. | Endovascular graft for providing a seal with vasculature |
US6610088B1 (en) | 2000-05-03 | 2003-08-26 | Shlomo Gabbay | Biologically covered heart valve prosthesis |
US6676698B2 (en) * | 2000-06-26 | 2004-01-13 | Rex Medicol, L.P. | Vascular device with valve for approximating vessel wall |
US6527800B1 (en) * | 2000-06-26 | 2003-03-04 | Rex Medical, L.P. | Vascular device and method for valve leaflet apposition |
US7510572B2 (en) | 2000-09-12 | 2009-03-31 | Shlomo Gabbay | Implantation system for delivery of a heart valve prosthesis |
DE10046550A1 (en) * | 2000-09-19 | 2002-03-28 | Adiam Life Science Ag | Prosthetic mitral heart valve consists of support housing with base ring and two stanchions |
US6893459B1 (en) | 2000-09-20 | 2005-05-17 | Ample Medical, Inc. | Heart valve annulus device and method of using same |
US6482228B1 (en) * | 2000-11-14 | 2002-11-19 | Troy R. Norred | Percutaneous aortic valve replacement |
US20050182483A1 (en) * | 2004-02-11 | 2005-08-18 | Cook Incorporated | Percutaneously placed prosthesis with thromboresistant valve portion |
US6733525B2 (en) | 2001-03-23 | 2004-05-11 | Edwards Lifesciences Corporation | Rolled minimally-invasive heart valves and methods of use |
US6716207B2 (en) | 2001-05-22 | 2004-04-06 | Scimed Life Systems, Inc. | Torqueable and deflectable medical device shaft |
FR2828091B1 (en) | 2001-07-31 | 2003-11-21 | Seguin Jacques | ASSEMBLY ALLOWING THE PLACEMENT OF A PROTHETIC VALVE IN A BODY DUCT |
FR2828263B1 (en) | 2001-08-03 | 2007-05-11 | Philipp Bonhoeffer | DEVICE FOR IMPLANTATION OF AN IMPLANT AND METHOD FOR IMPLANTATION OF THE DEVICE |
US6893460B2 (en) | 2001-10-11 | 2005-05-17 | Percutaneous Valve Technologies Inc. | Implantable prosthetic valve |
GB0125925D0 (en) | 2001-10-29 | 2001-12-19 | Univ Glasgow | Mitral valve prosthesis |
US7201771B2 (en) | 2001-12-27 | 2007-04-10 | Arbor Surgical Technologies, Inc. | Bioprosthetic heart valve |
US7264632B2 (en) | 2002-06-07 | 2007-09-04 | Medtronic Vascular, Inc. | Controlled deployment delivery system |
US8518096B2 (en) | 2002-09-03 | 2013-08-27 | Lifeshield Sciences Llc | Elephant trunk thoracic endograft and delivery system |
US6875231B2 (en) | 2002-09-11 | 2005-04-05 | 3F Therapeutics, Inc. | Percutaneously deliverable heart valve |
CO5500017A1 (en) | 2002-09-23 | 2005-03-31 | 3F Therapeutics Inc | MITRAL PROTESTIC VALVE |
JP2006501033A (en) | 2002-10-01 | 2006-01-12 | アンプル メディカル, インコーポレイテッド | Device, system and method for reshaping a heart valve annulus |
GB2398245B (en) | 2003-02-06 | 2007-03-28 | Great Ormond Street Hospital F | Valve prosthesis |
DE602004024766D1 (en) | 2003-03-12 | 2010-02-04 | Cook Inc | |
WO2004082528A2 (en) | 2003-03-17 | 2004-09-30 | Cook Incorporated | Vascular valve with removable support component |
US7201772B2 (en) * | 2003-07-08 | 2007-04-10 | Ventor Technologies, Ltd. | Fluid flow prosthetic device |
WO2005009285A2 (en) * | 2003-07-21 | 2005-02-03 | The Trustees Of The University Of Pennsylvania | Percutaneous heart valve |
WO2005011534A1 (en) | 2003-07-31 | 2005-02-10 | Cook Incorporated | Prosthetic valve devices and methods of making such devices |
DE10342757A1 (en) * | 2003-09-16 | 2005-04-07 | Campus Gmbh & Co. Kg | Stent with terminal anchoring elements |
US20050075717A1 (en) * | 2003-10-06 | 2005-04-07 | Nguyen Tuoc Tan | Minimally invasive valve replacement system |
US7553324B2 (en) | 2003-10-14 | 2009-06-30 | Xtent, Inc. | Fixed stent delivery devices and methods |
US7192440B2 (en) | 2003-10-15 | 2007-03-20 | Xtent, Inc. | Implantable stent delivery devices and methods |
US7740656B2 (en) | 2003-11-17 | 2010-06-22 | Medtronic, Inc. | Implantable heart valve prosthetic devices having intrinsically conductive polymers |
US7186265B2 (en) * | 2003-12-10 | 2007-03-06 | Medtronic, Inc. | Prosthetic cardiac valves and systems and methods for implanting thereof |
US7261732B2 (en) * | 2003-12-22 | 2007-08-28 | Henri Justino | Stent mounted valve |
US8052749B2 (en) * | 2003-12-23 | 2011-11-08 | Sadra Medical, Inc. | Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elements |
US8246675B2 (en) | 2003-12-23 | 2012-08-21 | Laboratoires Perouse | Kit for implanting in a duct |
US8182528B2 (en) * | 2003-12-23 | 2012-05-22 | Sadra Medical, Inc. | Locking heart valve anchor |
US9005273B2 (en) | 2003-12-23 | 2015-04-14 | Sadra Medical, Inc. | Assessing the location and performance of replacement heart valves |
US8287584B2 (en) | 2005-11-14 | 2012-10-16 | Sadra Medical, Inc. | Medical implant deployment tool |
US7445631B2 (en) | 2003-12-23 | 2008-11-04 | Sadra Medical, Inc. | Methods and apparatus for endovascularly replacing a patient's heart valve |
US20050137691A1 (en) * | 2003-12-23 | 2005-06-23 | Sadra Medical | Two piece heart valve and anchor |
US7824443B2 (en) | 2003-12-23 | 2010-11-02 | Sadra Medical, Inc. | Medical implant delivery and deployment tool |
US20120041550A1 (en) | 2003-12-23 | 2012-02-16 | Sadra Medical, Inc. | Methods and Apparatus for Endovascular Heart Valve Replacement Comprising Tissue Grasping Elements |
US7329279B2 (en) * | 2003-12-23 | 2008-02-12 | Sadra Medical, Inc. | Methods and apparatus for endovascularly replacing a patient's heart valve |
EP2529697B1 (en) * | 2003-12-23 | 2014-01-29 | Sadra Medical, Inc. | Repositionable heart valve |
US7959666B2 (en) | 2003-12-23 | 2011-06-14 | Sadra Medical, Inc. | Methods and apparatus for endovascularly replacing a heart valve |
US20050137694A1 (en) | 2003-12-23 | 2005-06-23 | Haug Ulrich R. | Methods and apparatus for endovascularly replacing a patient's heart valve |
US7780725B2 (en) | 2004-06-16 | 2010-08-24 | Sadra Medical, Inc. | Everting heart valve |
US7381219B2 (en) * | 2003-12-23 | 2008-06-03 | Sadra Medical, Inc. | Low profile heart valve and delivery system |
US20050137687A1 (en) * | 2003-12-23 | 2005-06-23 | Sadra Medical | Heart valve anchor and method |
JP4842144B2 (en) | 2003-12-23 | 2011-12-21 | サドラ・メディカル・インコーポレーテッド | Redeployable heart valve |
US20050137686A1 (en) | 2003-12-23 | 2005-06-23 | Sadra Medical, A Delaware Corporation | Externally expandable heart valve anchor and method |
US8343213B2 (en) | 2003-12-23 | 2013-01-01 | Sadra Medical, Inc. | Leaflet engagement elements and methods for use thereof |
PT2926766T (en) | 2003-12-23 | 2017-06-02 | Boston Scient Scimed Inc | Repositionable heart valve |
US7748389B2 (en) | 2003-12-23 | 2010-07-06 | Sadra Medical, Inc. | Leaflet engagement elements and methods for use thereof |
US7871435B2 (en) * | 2004-01-23 | 2011-01-18 | Edwards Lifesciences Corporation | Anatomically approximate prosthetic mitral heart valve |
AU2005213458B2 (en) | 2004-02-05 | 2010-04-22 | Children's Medical Center Corporation | Transcatheter delivery of a replacement heart valve |
US7311730B2 (en) | 2004-02-13 | 2007-12-25 | Shlomo Gabbay | Support apparatus and heart valve prosthesis for sutureless implantation |
US7320704B2 (en) | 2004-05-05 | 2008-01-22 | Direct Flow Medical, Inc. | Nonstented temporary valve for cardiovascular therapy |
US7462191B2 (en) | 2004-06-30 | 2008-12-09 | Edwards Lifesciences Pvt, Inc. | Device and method for assisting in the implantation of a prosthetic valve |
US7276078B2 (en) | 2004-06-30 | 2007-10-02 | Edwards Lifesciences Pvt | Paravalvular leak detection, sealing, and prevention |
US20060052867A1 (en) | 2004-09-07 | 2006-03-09 | Medtronic, Inc | Replacement prosthetic heart valve, system and method of implant |
EP2471492B1 (en) | 2004-10-02 | 2021-06-09 | Edwards Lifesciences CardiAQ LLC | Implantable heart valve |
US7563276B2 (en) * | 2004-10-29 | 2009-07-21 | Cook Incorporated | Intraluminal medical device with cannula for controlled retrograde flow |
US7402151B2 (en) | 2004-12-17 | 2008-07-22 | Biocardia, Inc. | Steerable guide catheters and methods for their use |
DE102005003632A1 (en) | 2005-01-20 | 2006-08-17 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Catheter for the transvascular implantation of heart valve prostheses |
US20060195183A1 (en) * | 2005-02-18 | 2006-08-31 | The Cleveland Clinic Foundation | Apparatus and methods for replacing a cardiac valve |
US7722666B2 (en) | 2005-04-15 | 2010-05-25 | Boston Scientific Scimed, Inc. | Valve apparatus, system and method |
SE531468C2 (en) | 2005-04-21 | 2009-04-14 | Edwards Lifesciences Ag | An apparatus for controlling blood flow |
US7914569B2 (en) | 2005-05-13 | 2011-03-29 | Medtronics Corevalve Llc | Heart valve prosthesis and methods of manufacture and use |
EP1883375B1 (en) | 2005-05-24 | 2016-12-07 | Edwards Lifesciences Corporation | Rapid deployment prosthetic heart valve |
US7780723B2 (en) | 2005-06-13 | 2010-08-24 | Edwards Lifesciences Corporation | Heart valve delivery system |
US8790396B2 (en) | 2005-07-27 | 2014-07-29 | Medtronic 3F Therapeutics, Inc. | Methods and systems for cardiac valve delivery |
US7455689B2 (en) | 2005-08-25 | 2008-11-25 | Edwards Lifesciences Corporation | Four-leaflet stented mitral heart valve |
US20070129794A1 (en) | 2005-10-05 | 2007-06-07 | Fidel Realyvasquez | Method and apparatus for prosthesis attachment using discrete elements |
US7563277B2 (en) | 2005-10-24 | 2009-07-21 | Cook Incorporated | Removable covering for implantable frame projections |
DE102005052628B4 (en) | 2005-11-04 | 2014-06-05 | Jenavalve Technology Inc. | Self-expanding, flexible wire mesh with integrated valvular prosthesis for the transvascular heart valve replacement and a system with such a device and a delivery catheter |
WO2007058857A2 (en) | 2005-11-10 | 2007-05-24 | Arshad Quadri | Balloon-expandable, self-expanding, vascular prosthesis connecting stent |
US8764820B2 (en) | 2005-11-16 | 2014-07-01 | Edwards Lifesciences Corporation | Transapical heart valve delivery system and method |
CA2633861A1 (en) | 2005-12-30 | 2007-07-12 | C.R. Bard Inc. | Embolus blood clot filter with bio-resorbable coated filter members |
EP1991168B1 (en) | 2006-02-16 | 2016-01-27 | Transcatheter Technologies GmbH | Minimally invasive heart valve replacement |
US8591516B2 (en) | 2006-02-27 | 2013-11-26 | Biomet Manufacturing, Llc | Patient-specific orthopedic instruments |
US8219229B2 (en) | 2006-03-02 | 2012-07-10 | Edwards Lifesciences Corporation | Virtual heart valve |
WO2007123658A1 (en) | 2006-03-28 | 2007-11-01 | Medtronic, Inc. | Prosthetic cardiac valve formed from pericardium material and methods of making same |
EP2023859B1 (en) | 2006-04-28 | 2012-12-26 | Medtronic, Inc. | Apparatus for cardiac valve replacement |
EP2012712B1 (en) | 2006-04-29 | 2016-02-10 | Medtronic, Inc. | Guide shields for multiple component prosthetic heart valve assemblies |
WO2007130537A1 (en) | 2006-05-05 | 2007-11-15 | Children's Medical Center Corporation | Transcatheter heart valve prostheses |
US20090270972A1 (en) | 2006-05-23 | 2009-10-29 | All-Vascular Pty Ltd. | Endovenous valve transfer stent |
EP2029054A2 (en) | 2006-06-01 | 2009-03-04 | Mor Research Applications Ltd. | Membrane augmentation, such as of for treatment of cardiac valves, and fastening devices for membrane augmentation |
US20080021546A1 (en) * | 2006-07-18 | 2008-01-24 | Tim Patz | System for deploying balloon-expandable heart valves |
WO2008013915A2 (en) | 2006-07-28 | 2008-01-31 | Arshad Quadri | Percutaneous valve prosthesis and system and method for implanting same |
US20100179647A1 (en) * | 2006-09-11 | 2010-07-15 | Carpenter Judith T | Methods of reducing embolism to cerebral circulation as a consequence of an index cardiac procedure |
US8834564B2 (en) | 2006-09-19 | 2014-09-16 | Medtronic, Inc. | Sinus-engaging valve fixation member |
US8876895B2 (en) | 2006-09-19 | 2014-11-04 | Medtronic Ventor Technologies Ltd. | Valve fixation member having engagement arms |
FR2906454B1 (en) | 2006-09-28 | 2009-04-10 | Perouse Soc Par Actions Simpli | IMPLANT INTENDED TO BE PLACED IN A BLOOD CIRCULATION CONDUIT. |
AU2007299934B2 (en) | 2006-09-28 | 2013-09-12 | Hlt, Inc. | Delivery tool for percutaneous delivery of a prosthesis |
US7534261B2 (en) | 2006-10-02 | 2009-05-19 | Edwards Lifesciences Corporation | Sutureless heart valve attachment |
WO2008047354A2 (en) | 2006-10-16 | 2008-04-24 | Ventor Technologies Ltd. | Transapical delivery system with ventriculo-arterial overflow bypass |
DE102006052564B3 (en) | 2006-11-06 | 2007-12-13 | Georg Lutter | Mitral valve stent for surgical implantation and fixation of heart valve prosthesis to heart, has stent clips arranged distally, where one of stent clips forms section that is externally rolled in unfolded condition of stent |
CA2664557C (en) | 2006-11-07 | 2015-05-26 | David Stephen Celermajer | Devices and methods for the treatment of heart failure |
US9456877B2 (en) | 2006-12-01 | 2016-10-04 | Boston Scientific Scimed, Inc. | Direct drive instruments and methods of use |
WO2008070797A2 (en) | 2006-12-06 | 2008-06-12 | Medtronic Corevalve, Inc. | System and method for transapical delivery of an annulus anchored self-expanding valve |
FR2909857B1 (en) * | 2006-12-14 | 2009-03-06 | Perouse Soc Par Actions Simpli | Endovalve. |
DE602006013167D1 (en) | 2006-12-19 | 2010-05-06 | Sorin Biomedica Cardio Srl | Instrument for in situ insertion of heart valve prostheses |
US8236045B2 (en) * | 2006-12-22 | 2012-08-07 | Edwards Lifesciences Corporation | Implantable prosthetic valve assembly and method of making the same |
WO2008091515A2 (en) | 2007-01-19 | 2008-07-31 | Medtronic, Inc. | Stented heart valve devices and methods for atrioventricular valve replacement |
WO2008089365A2 (en) * | 2007-01-19 | 2008-07-24 | The Cleveland Clinic Foundation | Method for implanting a cardiovascular valve |
ES2441801T3 (en) * | 2007-02-05 | 2014-02-06 | Boston Scientific Limited | Percutaneous valve and supply system |
US8623074B2 (en) | 2007-02-16 | 2014-01-07 | Medtronic, Inc. | Delivery systems and methods of implantation for replacement prosthetic heart valves |
US8070802B2 (en) | 2007-02-23 | 2011-12-06 | The Trustees Of The University Of Pennsylvania | Mitral valve system |
US20080208328A1 (en) | 2007-02-23 | 2008-08-28 | Endovalve, Inc. | Systems and Methods For Placement of Valve Prosthesis System |
EP2155115B1 (en) | 2007-04-13 | 2018-09-05 | JenaValve Technology, Inc. | Medical device for treating a heart valve insufficiency or stenosis |
EP2659861B1 (en) | 2007-05-15 | 2019-03-13 | JenaValve Technology, Inc. | Handle for manipulating a catheter tip, catheter system and medical insertion system for inserting a self-expandable heart valve stent |
EP2420205B1 (en) | 2007-06-26 | 2014-04-09 | St. Jude Medical, Inc. | Apparatus for implanting collapsible/expandable prosthetic heart valves |
US8828079B2 (en) | 2007-07-26 | 2014-09-09 | Boston Scientific Scimed, Inc. | Circulatory valve, system and method |
US8747458B2 (en) * | 2007-08-20 | 2014-06-10 | Medtronic Ventor Technologies Ltd. | Stent loading tool and method for use thereof |
EP2190379B1 (en) | 2007-08-23 | 2016-06-15 | Direct Flow Medical, Inc. | Translumenally implantable heart valve with formed in place support |
DE102007043830A1 (en) | 2007-09-13 | 2009-04-02 | Lozonschi, Lucian, Madison | Heart valve stent |
US8220121B2 (en) * | 2007-09-14 | 2012-07-17 | Cook Medical Technologies Llc | Device for loading a self-expandable prosthesis into a sheath |
US20090138079A1 (en) * | 2007-10-10 | 2009-05-28 | Vector Technologies Ltd. | Prosthetic heart valve for transfemoral delivery |
CA2702672C (en) | 2007-10-15 | 2016-03-15 | Edwards Lifesciences Corporation | Transcatheter heart valve with micro-anchors |
US8647381B2 (en) * | 2007-10-25 | 2014-02-11 | Symetis Sa | Stents, valved-stents, and methods and systems for delivery thereof |
US20090171456A1 (en) | 2007-12-28 | 2009-07-02 | Kveen Graig L | Percutaneous heart valve, system, and method |
EP2252240B1 (en) * | 2008-01-14 | 2012-08-01 | Boston Scientific Scimed, Inc. | Stent delivery device with luer or clamp-type suture release apparatus |
WO2009091509A1 (en) | 2008-01-16 | 2009-07-23 | St. Jude Medical, Inc. | Delivery and retrieval systems for collapsible/expandable prosthetic heart valves |
US8628566B2 (en) | 2008-01-24 | 2014-01-14 | Medtronic, Inc. | Stents for prosthetic heart valves |
US7972378B2 (en) | 2008-01-24 | 2011-07-05 | Medtronic, Inc. | Stents for prosthetic heart valves |
US8157853B2 (en) | 2008-01-24 | 2012-04-17 | Medtronic, Inc. | Delivery systems and methods of implantation for prosthetic heart valves |
EP2247263B1 (en) * | 2008-01-24 | 2011-08-03 | Medtronic Vascular Inc. | Infundibular reducer device delivery system and related methods |
US8465540B2 (en) | 2008-02-26 | 2013-06-18 | Jenavalve Technology, Inc. | Stent for the positioning and anchoring of a valvular prosthesis |
CN103637861B (en) | 2008-02-29 | 2016-05-25 | 爱德华兹生命科学公司 | For disposing the expandable element of prosthetic appliance |
DE102008012113A1 (en) | 2008-03-02 | 2009-09-03 | Transcatheter Technologies Gmbh | Implant e.g. heart-valve-carrying stent, for e.g. arresting blood vessel, has fiber by which section of implant is reducible according to increasing of implant at extended diameter by unfolding or expansion of diameter with expansion unit |
DK3967274T3 (en) | 2008-04-23 | 2022-10-03 | Medtronic Inc | HEART VALVE DEVICES WITH STENT |
MX2010011389A (en) * | 2008-04-23 | 2011-01-14 | Medtronic Inc | Stented heart valve devices. |
US8136218B2 (en) | 2008-04-29 | 2012-03-20 | Medtronic, Inc. | Prosthetic heart valve, prosthetic heart valve assembly and method for making same |
US20090276027A1 (en) | 2008-05-01 | 2009-11-05 | Medtronic Vasscular, Inc. | Stent Graft Delivery System and Method of Use |
US20090276040A1 (en) | 2008-05-01 | 2009-11-05 | Edwards Lifesciences Corporation | Device and method for replacing mitral valve |
HUE047762T2 (en) | 2008-06-06 | 2020-05-28 | Edwards Lifesciences Corp | Low profile transcatheter heart valve |
US8323335B2 (en) | 2008-06-20 | 2012-12-04 | Edwards Lifesciences Corporation | Retaining mechanisms for prosthetic valves and methods for using |
ES2749741T3 (en) | 2008-06-30 | 2020-03-23 | Bolton Medical Inc | Abdominal aortic aneurysm systems |
US8652202B2 (en) | 2008-08-22 | 2014-02-18 | Edwards Lifesciences Corporation | Prosthetic heart valve and delivery apparatus |
US8721714B2 (en) | 2008-09-17 | 2014-05-13 | Medtronic Corevalve Llc | Delivery system for deployment of medical devices |
AU2009295960A1 (en) * | 2008-09-29 | 2010-04-01 | Cardiaq Valve Technologies, Inc. | Heart valve |
EP2341871B1 (en) * | 2008-10-01 | 2017-03-22 | Edwards Lifesciences CardiAQ LLC | Delivery system for vascular implant |
CA2739961A1 (en) | 2008-10-10 | 2010-04-15 | Sadra Medical, Inc. | Medical devices and delivery systems for delivering medical devices |
US8690936B2 (en) | 2008-10-10 | 2014-04-08 | Edwards Lifesciences Corporation | Expandable sheath for introducing an endovascular delivery device into a body |
US8790387B2 (en) | 2008-10-10 | 2014-07-29 | Edwards Lifesciences Corporation | Expandable sheath for introducing an endovascular delivery device into a body |
US20100114305A1 (en) | 2008-10-30 | 2010-05-06 | Wei-Chang Kang | Implantable Valvular Prosthesis |
US8500733B2 (en) | 2009-02-20 | 2013-08-06 | Boston Scientific Scimed, Inc. | Asymmetric dual directional steerable catheter sheath |
US20100217382A1 (en) | 2009-02-25 | 2010-08-26 | Edwards Lifesciences | Mitral valve replacement with atrial anchoring |
CA2757273C (en) | 2009-03-30 | 2017-05-02 | Cardiovantage Medical, Inc. | Sutureless valve prostheses and devices and methods for delivery |
US9980818B2 (en) | 2009-03-31 | 2018-05-29 | Edwards Lifesciences Corporation | Prosthetic heart valve system with positioning markers |
EP2419050B2 (en) * | 2009-04-15 | 2023-10-18 | Edwards Lifesciences CardiAQ LLC | Vascular implant and delivery system |
US8075611B2 (en) | 2009-06-02 | 2011-12-13 | Medtronic, Inc. | Stented prosthetic heart valves |
AU2010266210B2 (en) * | 2009-07-02 | 2015-01-22 | The Cleveland Clinic Foundation | Apparatus and method for replacing a diseased cardiac valve |
US20110022165A1 (en) * | 2009-07-23 | 2011-01-27 | Edwards Lifesciences Corporation | Introducer for prosthetic heart valve |
AU2010286587B2 (en) * | 2009-08-27 | 2013-10-17 | Medtronic Inc. | Transcatheter valve delivery systems and methods |
WO2011025972A2 (en) | 2009-08-28 | 2011-03-03 | 3F Therapeutics, Inc. | Crimping device and method of use |
US9757107B2 (en) | 2009-09-04 | 2017-09-12 | Corvia Medical, Inc. | Methods and devices for intra-atrial shunts having adjustable sizes |
US9730790B2 (en) * | 2009-09-29 | 2017-08-15 | Edwards Lifesciences Cardiaq Llc | Replacement valve and method |
US8449599B2 (en) | 2009-12-04 | 2013-05-28 | Edwards Lifesciences Corporation | Prosthetic valve for replacing mitral valve |
EP2512375B1 (en) | 2009-12-15 | 2016-12-07 | Edwards Lifesciences Corporation | Expansion device for treatment of vascular passageways |
US8475523B2 (en) | 2010-02-17 | 2013-07-02 | Medtronic, Inc. | Distal tip assembly for a heart valve delivery catheter |
US8795354B2 (en) | 2010-03-05 | 2014-08-05 | Edwards Lifesciences Corporation | Low-profile heart valve and delivery system |
US8679404B2 (en) | 2010-03-05 | 2014-03-25 | Edwards Lifesciences Corporation | Dry prosthetic heart valve packaging system |
WO2011111047A2 (en) | 2010-03-10 | 2011-09-15 | Mitraltech Ltd. | Prosthetic mitral valve with tissue anchors |
JP2013523282A (en) | 2010-03-31 | 2013-06-17 | ボストン サイエンティフィック サイムド,インコーポレイテッド | Guide wire with bending stiffness profile |
US8623079B2 (en) | 2010-04-23 | 2014-01-07 | Medtronic, Inc. | Stents for prosthetic heart valves |
US9387077B2 (en) | 2010-05-27 | 2016-07-12 | Medtronic Vascular Galway | Catheter assembly with prosthesis crimping and prosthesis retaining accessories |
EP3061422B1 (en) | 2010-06-21 | 2021-11-03 | Edwards Lifesciences CardiAQ LLC | Replacement heart valve |
US9132009B2 (en) * | 2010-07-21 | 2015-09-15 | Mitraltech Ltd. | Guide wires with commissural anchors to advance a prosthetic valve |
AU2011292460B2 (en) | 2010-08-17 | 2014-03-13 | St. Jude Medical, Inc. | Delivery system for collapsible heart valve |
US10321998B2 (en) | 2010-09-23 | 2019-06-18 | Transmural Systems Llc | Methods and systems for delivering prostheses using rail techniques |
EP3001978B2 (en) * | 2010-09-23 | 2023-03-01 | Edwards Lifesciences CardiAQ LLC | Replacement heart valve delivery device |
US20120078360A1 (en) | 2010-09-23 | 2012-03-29 | Nasser Rafiee | Prosthetic devices, systems and methods for replacing heart valves |
US8845720B2 (en) | 2010-09-27 | 2014-09-30 | Edwards Lifesciences Corporation | Prosthetic heart valve frame with flexible commissures |
SI3669828T1 (en) | 2010-10-05 | 2021-08-31 | Edwards Lifesciences Corporation | Prosthetic heart valve |
EP2629699B1 (en) | 2010-10-21 | 2017-01-04 | Medtronic, Inc. | Mitral bioprosthesis with low ventricular profile |
US9072872B2 (en) | 2010-10-29 | 2015-07-07 | Medtronic, Inc. | Telescoping catheter delivery system for left heart endocardial device placement |
GB2485338B (en) | 2010-11-02 | 2012-12-05 | Cook Medical Technologies Llc | Introducer assembly and dilator tip therefor |
EP2663258B1 (en) | 2011-01-11 | 2018-11-21 | Hans Reiner Figulla | Prosthetic valve for replacing an atrioventricular heart valve |
EP2688516B1 (en) | 2011-03-21 | 2022-08-17 | Cephea Valve Technologies, Inc. | Disk-based valve apparatus |
US9055937B2 (en) | 2011-04-01 | 2015-06-16 | Edwards Lifesciences Corporation | Apical puncture access and closure system |
US8945209B2 (en) | 2011-05-20 | 2015-02-03 | Edwards Lifesciences Corporation | Encapsulated heart valve |
US9289282B2 (en) | 2011-05-31 | 2016-03-22 | Edwards Lifesciences Corporation | System and method for treating valve insufficiency or vessel dilatation |
WO2012177942A2 (en) | 2011-06-21 | 2012-12-27 | Hanson Gifford, Iii | Prosthetic heart valve devices and associated systems and methods |
EP2723272A4 (en) | 2011-06-24 | 2015-01-28 | Inceptus Medical LLC | Percutaneously implantable artificial heart valve system and associated methods and devices |
US8795357B2 (en) | 2011-07-15 | 2014-08-05 | Edwards Lifesciences Corporation | Perivalvular sealing for transcatheter heart valve |
EP2734153A2 (en) | 2011-07-20 | 2014-05-28 | Boston Scientific Scimed, Inc. | Heart valve replacement |
US9549817B2 (en) | 2011-09-22 | 2017-01-24 | Transmural Systems Llc | Devices, systems and methods for repairing lumenal systems |
WO2013131069A1 (en) | 2012-03-02 | 2013-09-06 | Mehr Medical Llc | Prostheses |
US9655722B2 (en) | 2011-10-19 | 2017-05-23 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
CA2848334C (en) | 2011-10-19 | 2020-10-20 | Twelve, Inc. | Devices, systems and methods for heart valve replacement |
WO2013070896A1 (en) | 2011-11-08 | 2013-05-16 | Boston Scientific Scimed Inc. | Replacement heart valve leaflet stitching method and device |
US8652145B2 (en) | 2011-12-14 | 2014-02-18 | Edwards Lifesciences Corporation | System and method for crimping a prosthetic valve |
US9277993B2 (en) | 2011-12-20 | 2016-03-08 | Boston Scientific Scimed, Inc. | Medical device delivery systems |
US20140100651A1 (en) | 2012-02-21 | 2014-04-10 | California Institute Of Technology | Medical Device Fastener Mechanisms |
GB2500432A (en) | 2012-03-22 | 2013-09-25 | Stephen Brecker | Replacement heart valve with resiliently deformable securing means |
ES2535295T3 (en) | 2012-03-23 | 2015-05-08 | Sorin Group Italia S.R.L. | Folding valve prosthesis |
US9445897B2 (en) | 2012-05-01 | 2016-09-20 | Direct Flow Medical, Inc. | Prosthetic implant delivery device with introducer catheter |
US9277990B2 (en) | 2012-05-04 | 2016-03-08 | St. Jude Medical, Cardiology Division, Inc. | Hypotube shaft with articulation mechanism |
US9232995B2 (en) | 2013-01-08 | 2016-01-12 | Medtronic, Inc. | Valve prosthesis and method for delivery |
CN103655004B (en) | 2012-09-21 | 2015-11-25 | 上海微创医疗器械(集团)有限公司 | Implant delivery system |
JP2016501649A (en) | 2012-12-27 | 2016-01-21 | トランスカテーテル テクノロギース ゲーエムベーハーTranscatheter Technologies Gmbh | Apparatus and set, implant and method for folding or deploying a medical implant with a clamping mechanism |
US9132007B2 (en) | 2013-01-10 | 2015-09-15 | Medtronic CV Luxembourg S.a.r.l. | Anti-paravalvular leakage components for a transcatheter valve prosthesis |
US9439763B2 (en) | 2013-02-04 | 2016-09-13 | Edwards Lifesciences Corporation | Prosthetic valve for replacing mitral valve |
US9844435B2 (en) | 2013-03-01 | 2017-12-19 | St. Jude Medical, Cardiology Division, Inc. | Transapical mitral valve replacement |
US9119713B2 (en) | 2013-03-11 | 2015-09-01 | St. Jude Medical, Cardiology Division, Inc. | Transcatheter valve replacement |
US9730791B2 (en) | 2013-03-14 | 2017-08-15 | Edwards Lifesciences Cardiaq Llc | Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery |
US9681951B2 (en) | 2013-03-14 | 2017-06-20 | Edwards Lifesciences Cardiaq Llc | Prosthesis with outer skirt and anchors |
US20140277427A1 (en) | 2013-03-14 | 2014-09-18 | Cardiaq Valve Technologies, Inc. | Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery |
ES2940104T3 (en) | 2013-03-15 | 2023-05-03 | Twelve Inc | Prosthetic heart valve devices, prosthetic mitral valves, and associated systems |
EP2777617B1 (en) | 2013-03-15 | 2022-09-14 | Edwards Lifesciences CardiAQ LLC | Prosthesis with outer skirt |
CN105101894B (en) | 2013-05-09 | 2019-03-19 | 美国奥林匹斯外科技术吉鲁斯阿克米公司 | Multimode oscillation stone crusher |
ES2699785T3 (en) | 2013-05-20 | 2019-02-12 | Edwards Lifesciences Corp | Device for the administration of cardiac prosthetic valve |
US9788943B2 (en) | 2013-06-11 | 2017-10-17 | Medtronic, Inc. | Delivery system with inline sheath |
US9468527B2 (en) | 2013-06-12 | 2016-10-18 | Edwards Lifesciences Corporation | Cardiac implant with integrated suture fasteners |
WO2014210124A1 (en) | 2013-06-25 | 2014-12-31 | Mark Christianson | Thrombus management and structural compliance features for prosthetic heart valves |
US10524904B2 (en) | 2013-07-11 | 2020-01-07 | Medtronic, Inc. | Valve positioning device |
EP2826443B1 (en) | 2013-07-16 | 2017-06-28 | Venus MedTech (HangZhou), Inc. | Set comprising an apparatus and a medical implant |
US9561103B2 (en) | 2013-07-17 | 2017-02-07 | Cephea Valve Technologies, Inc. | System and method for cardiac valve repair and replacement |
EP2832316B1 (en) | 2013-07-31 | 2017-03-29 | Venus MedTech (HangZhou), Inc. | Handle assembly for implant delivery apparatus comprising a displacement limiter, a force limiter and/or a brake frame assembly |
EP2832318B1 (en) | 2013-07-31 | 2017-04-05 | Venus MedTech (HangZhou), Inc. | Handle assembly for implant delivery apparatus comprising a force limiter, a displacement limiter and/or a brake frame assembly |
EP2832315B1 (en) | 2013-07-31 | 2017-11-22 | Venus MedTech (HangZhou), Inc. | Handle assembly for implant delivery apparatus comprising a brake frame assembly, a force limiter and/or a displacement limiter |
EP2918246B1 (en) | 2014-03-14 | 2018-08-08 | Venus MedTech (HangZhou), Inc. | Heart valve assembly comprising twofold sealing |
EP3046511B1 (en) | 2013-09-16 | 2018-03-28 | Symetis SA | Method and apparatus for compressing/loading stent-valves |
EP3057541B1 (en) | 2013-10-15 | 2018-01-10 | Boston Scientific Scimed, Inc. | Methods and systems for loading and delivering a stent |
US9925045B2 (en) | 2013-10-21 | 2018-03-27 | Medtronic Vascular Galway | Systems, devices and methods for transcatheter valve delivery |
US9839765B2 (en) | 2013-11-12 | 2017-12-12 | St. Jude Medical, Cardiology Division, Inc. | Transfemoral mitral valve repair delivery device |
US10368989B2 (en) | 2014-04-17 | 2019-08-06 | Medtronic Vascular Galway | Hinged transcatheter prosthetic heart valve delivery system |
USRE49792E1 (en) | 2014-05-14 | 2024-01-09 | Corcym S.R.L. | Implant device and implantation kit |
EP3037064B1 (en) | 2014-12-23 | 2018-03-14 | Venus MedTech (HangZhou), Inc. | Minimally invasive mitral valve replacement with brim |
US9861477B2 (en) | 2015-01-26 | 2018-01-09 | Boston Scientific Scimed Inc. | Prosthetic heart valve square leaflet-leaflet stitch |
CA2973940C (en) | 2015-02-05 | 2022-08-23 | Mitraltech Ltd. | Prosthetic valve with axially-sliding frames |
US10849746B2 (en) | 2015-05-14 | 2020-12-01 | Cephea Valve Technologies, Inc. | Cardiac valve delivery devices and systems |
US10433952B2 (en) | 2016-01-29 | 2019-10-08 | Neovasc Tiara Inc. | Prosthetic valve for avoiding obstruction of outflow |
US10278852B2 (en) | 2016-03-10 | 2019-05-07 | Medtronic Vascular, Inc. | Steerable catheter with multiple bending radii via a steering mechanism with telescoping tubular components |
US10624740B2 (en) | 2016-05-13 | 2020-04-21 | St. Jude Medical, Cardiology Division, Inc. | Mitral valve delivery device |
CN111759368A (en) | 2016-06-02 | 2020-10-13 | 美敦力瓦斯科尔勒公司 | Transcatheter valve delivery system with septal orifice closure tip assembly |
US11045315B2 (en) | 2016-08-29 | 2021-06-29 | Cephea Valve Technologies, Inc. | Methods of steering and delivery of intravascular devices |
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US20190321174A1 (en) | 2019-10-24 |
WO2008013915A9 (en) | 2008-08-21 |
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US20160331532A1 (en) | 2016-11-17 |
US11141265B2 (en) | 2021-10-12 |
US20090306768A1 (en) | 2009-12-10 |
WO2008013915A2 (en) | 2008-01-31 |
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