DE102006052564B3 - Mitral valve stent for surgical implantation and fixation of heart valve prosthesis to heart, has stent clips arranged distally, where one of stent clips forms section that is externally rolled in unfolded condition of stent - Google Patents

Mitral valve stent for surgical implantation and fixation of heart valve prosthesis to heart, has stent clips arranged distally, where one of stent clips forms section that is externally rolled in unfolded condition of stent Download PDF

Info

Publication number
DE102006052564B3
DE102006052564B3 DE200610052564 DE102006052564A DE102006052564B3 DE 102006052564 B3 DE102006052564 B3 DE 102006052564B3 DE 200610052564 DE200610052564 DE 200610052564 DE 102006052564 A DE102006052564 A DE 102006052564A DE 102006052564 B3 DE102006052564 B3 DE 102006052564B3
Authority
DE
Germany
Prior art keywords
stent
mitral valve
heart
valve
clips
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE200610052564
Other languages
German (de)
Inventor
Georg Lutter
Original Assignee
Georg Lutter
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Georg Lutter filed Critical Georg Lutter
Priority to DE200610052564 priority Critical patent/DE102006052564B3/en
Application granted granted Critical
Publication of DE102006052564B3 publication Critical patent/DE102006052564B3/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2418Scaffolds therefor, e.g. support stents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0008Fixation appliances for connecting prostheses to the body
    • A61F2220/0016Fixation appliances for connecting prostheses to the body with sharp anchoring protrusions, e.g. barbs, pins, spikes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0028Shapes in the form of latin or greek characters
    • A61F2230/005Rosette-shaped, e.g. star-shaped

Abstract

A collapsible mitral valve stent (10) having a plurality of distally disposed stent bars (20) and a plurality of proximal anchoring elements (30), characterized in that the mitral valve stent (10) comprises at least one stent bar forming a spiraling outward portion in the deployed state (20 ').

Description

  • The The invention relates to a foldable mitral valve stent with a A plurality of distally disposed stent bars and a plurality of proximally arranged anchoring elements.
  • The Surgical implantation of heart valve prostheses is cardioplegic (heart-stopping) hearts performed (Golden Standard). The old, impaired in their function Heart valve is usually cut out and implanted heart valve prosthesis sewn.
  • at Presence of diseases of the mitral valve, however, it is attempted the old flap as much as possible despite malfunction occurred so that the entire mitral valve apparatus is not destroyed. This is because, e.g. the tendon threads attached to the mitral valve take on, very important for the ventricular function are and therefore not possible from the old one Mitral valve detached should be. Ideal, therefore, the mitral valve as far as possible to push aside, to make way for the new flap if it is not reconstructed can be. The course plays a not so serious role here as in the aortic annulus, which is much easier to narrow Comes off (for example, when displacing the old aortic valve with purely percutaneous implantation).
  • The chordae (Chordae tendineae) of the mitral valve should if possible retained in their structure to the ventricular geometry as far as possible to obtain and thus the best possible To maintain and reach the function of the left ventricle.
  • in this connection Again, it is very important that the anterior (anterior) mitral valve sails does not simply push in the free space towards the left ventricle, but attached to the mitral valve Armalus, so that one Forward-urging the front Mitral valve leaflet into the outflow tract of the left ventricle (Sam phenomenon: systolic Anterior Movement) is prevented. This is very important because otherwise it quickly leads to left heart decompensation (massive misconduct of the left ventricle).
  • surgical so the old mitral valve is attached to the old annulus, so that unimpeded blood flow through the flap and through the is given to both adjoining chambers of the heart. After pushing back (the Attaching the flap to the annulus) becomes the prosthetic heart valve surgically implanted in this annulus.
  • These Complex method is obligatory under the help the heart-lung machine and comes for High-risk patients do not regularly in question, so after minimally invasive or percutaneous methods was sought for implantation of a heart valve.
  • So is out of the DE 195 46 692 C2 or in EP 1 469 797 B1 a self-expandable heart valve prosthesis for implantation in the human body via a catheter system with a heart valve and with a collapsible and expandable stent connected to the heart valve known.
  • A Such self-expanding heart valve prosthesis can with the help of a Catheter system through a groin artery up to the implantation site led by the heart become. After reaching the implantation site can then such Stent in its longitudinal direction from a plurality of self-expanding relatively bendable Segments is gradually unfolded. To The unfolding can also assist the heart valve prosthesis Anchoring hook anchored at least in the immediate vicinity of the respective blood vessel become. The actual heart valve prosthesis is here in the proximal portion of the stent.
  • Another device for attachment and anchoring of hereditary prostheses is in the DE 100 10 074 A1 described, which is formed essentially of wire-shaped interconnected elements. Various brackets are used here to achieve a secure attachment and support of a heart valve.
  • at these known solutions However, there is a risk of incorrect implantation of Herklappen in the exact positioning and the angular alignment of the heart valve prostheses to be implanted.
  • Improved positioning and angular alignment with the aortic valve can be achieved through the stent 's stent EP 1 469 797 B1 be achieved, are formed in the so-called support bracket, which are insertable into the aortic pockets and thus produce a defined distance to the aortic valve.
  • In addition, it is also possible to cancel a failed implantation of a heart valve prosthesis and pull the valve stent (flap integrated into a stent) back into the catheter system (more precisely, the cartridge). In this case, the entire stent is then folded back and returned to the catheter opening (cartridge). It is possible to let the stent slide out again, if a good positioning for the valve stent is achieved. Thus, the valve stent can be brought in and out until the optimal positioning is achieved ("sli ding technique ").
  • To the Positioning the stent can cables for the Cartridge or for single catheter portions are used, thus allowing flexibility in all directions for the catheter system is reached and the valve stent with it vertically positioned to the valve plane and centered to the native opening of the valve can be.
  • One much bigger problem for the optimal placement of the new heart valve in the stent (or valve stent) However, that is the old native flap in most make the implantation technique described above should not be removed.
  • This for though to that the new flap, which in an old, deformed flap pushed (partially squeezed in), in its original Stent form is modified. This is because the implantation site for the Flap stent by morphology, condition and texture the old native valve (e.g., rash sclerosis) or calcification of the native valve).
  • Therefore determines the old valve annulus with the associated modified flaps / pockets to what extent and where the new flap unfolds and thus in their shape can develop. Thus, not only the anchoring / positioning important to optimal rattle function and atrial and ventricular function but also fitting the valve stent in the Neo-annulus (old valve annulus forms this with old valve aus) and thus the pushing back of the old flap.
  • outgoing of the problems encountered with the known Stens, it is therefore the object of the invention to provide a stent, the anantomy the heart as possible unaffected. In particular, a stent for receiving a Mitralldappenprothese be created, at the implantation of the valve shares the old mitral valve no longer disturb the flow of blood (in particular the anterior mitral valve leaflet) and on the other hand the tendon thread tension preserved in the ventricle.
  • According to the invention this Task by a Mitralklappenstent with the features of the claim 1 solved. Advantageous embodiments and developments of the invention are provided with the features indicated in the subordinate claims reached.
  • The The basic idea of the invention is the advantages of an invasive, surgical Fixing the anterior mitral valve leaflet to the old annulus with the benefits of minimally invasive surgery by introducing a in a catheter guided stents to unite that the stent according to the invention, the curling of the Anterior Mitralklappensegels causes and thus to similarly advantageous conditions as in the surgical attachment of the mitral valve to the annulus leads.
  • The The invention will be described below with reference to the attached drawings illustrated particularly preferred embodiment explained in more detail. It demonstrate:
  • 1a a side view of the stent according to the invention;
  • 1b a plan view of the stent according to the invention;
  • 1c a perspective view of the stent according to the invention obliquely from above;
  • 1d a lateral view of the stent according to the invention;
  • 1e another lateral view of the stent according to the invention;
  • 1f another lateral view of the stent according to the invention;
  • 1g a side view of the stent in the folded state;
  • 2 a perspective view of the stent according to the invention;
  • 3 a top view of the stent according to the invention;
  • 4 a detailed view of a stent strap with reinforcement of the ventricular portion;
  • 5 a detailed view of a stent strap with loops in the proximal and distal middle third to obtain the elasticity or a possible fixation of tissue or the heart valve prosthesis;
  • 6 a detailed view of a stent (atrial to ventricular) stent with fasteners designed as eyelets for attachment of a sealing membrane (seal between stent and flap);
  • 7 a schematic sequence of the rolling process of a ventricular stent bar to form a "Mozartlocke" from the anterior mitral valve leaflets;
  • 8th a representation of the heart with lin atrial and left ventricle and surrounding structures in a first stage of the surgical procedure for implantation of a heart valve;
  • 9 a representation of the heart opposite one 8th slightly advanced stage of the course of the operation;
  • 10 a representation of an operating stage at the time of stent delivery;
  • 11 a representation of an operating stage at the time of positioning of the stent according to the invention;
  • 12 a representation of an operation stage with almost complete expansion of the stent,
  • 13 a representation of the spatial relationships after placement of the stent according to the invention under fixing the stent by rolling the old anterior mitral valve leaflet on the anterior side and
  • 14 an enlarged view of the anterior mitral valve leaflet when the stent is fully inserted in situ.
  • The 1A - 1G show the stent according to the invention for implantation and attachment of heart valve prosthesis in various views to illustrate the structure of the stent and the spatial relationships of the individual stent sections to each other in an unfolded state ( 1A - 1F ) and a folded state ( 1G ). The dimensions have been found to be advantageous for mitral valve implantation.
  • 2 shows the foldable mitral valve stent 10 according to the invention in a perspective side view similar to in 1C shown view. The stent 10 essentially has two sections, which may each be subdivided into further subsections. Proximal are on the stent 10 circular a variety of anchoring elements 30 arranged the mitral valve stent 10 anchored in the implanted state supravalvular or atrial. Di- Distal are located a variety of stent bars 20 , which preferably has a first section adjacent to the anchoring elements 20a have, at which a second section 20b is formed, the free end of which is at a defined angle from the first section 20a (in 1F it is for example 40 °). This second section 20b is for ventricular anchoring of the stent 10 set up.
  • 3 shows the stent 2 in a top view. It can be seen that the stent 10 forms a ring into which the heart valve prosthesis can be inserted and attached. Furthermore, it can be seen that the stent according to the invention 10 in terms of the variety of stent bars 20 may be asymmetrical. This can be seen from the fact that with reference numerals 20 characterized Stentbügelabschnitte 20b only the left half of the stent according to the invention 10 taking.
  • 4 shows a section of the perspective view of the stent 2 that should make it clear that the second section 20b of the stent strap 20 is formed reinforced.
  • To achieve an elasticity of the anchoring elements 30 and the stent strap 20 or the first section 20a and the second section 20b of the stent strap 20 to each other are preferably eyelets forming loops 40 . 50 intended. These spring elements 40 . 50 on the one hand have the function that the stent according to the invention 10 Foldable and self-expanding from the folded state to the unfolded state. Furthermore, these spring elements 40 . 50 but also for fixing the stent 10 on the tissue or the heart valve prosthesis (not shown).
  • Additionally or alternatively to the designed as a loop-like loops spring elements 40 . 50 can also fasteners 60 . 70 be provided, which may also be formed as eyelets and, for example, for attaching the stent 10 on myocardial tissue or between the heart valve prosthesis and the stent 10 arranged sealing membrane (not shown) can be used.
  • 7 illustrates the basic idea of the invention with reference to a sequential representation of the stent according to the invention 10 caused rolling-in of the anterior mitral valve leaflet in a detail drawing of the stent 10 , According to the invention, at least one stent bar 20 ' namely the stent bar 20 ' which will be facing the anterior mitral valve leaflet, formed so as to have a portion extending upon deployment of the stent 10 spiraling outwards and remaining in this state at full deployment. This process is preferably produced in that at least this one stent 20 ' consists of a shape memory alloy. This can be, for example, NiTiNol, another alloy or even plastics which have this memory effect.
  • The following is the introduction of the stent according to the invention 10 to its predetermined place in the human heart for further veran Illustrate the invention with reference to the 8th - 14 explained.
  • The stent 10 will preferably carry a heart valve prosthesis (not shown) (see above) and will then also function as a valve stent 10 designated. The stent 10 preferably has the in 1 shown dimensions and is designed so that in folded form in one with a in 8th shown catheter connectable cartridge 100 can be included. The stent 10 should be compressed so that all parts have a certain degree of radially outward bias, after release by a cartridge 100 cause the self-expansion (eg by the spring elements 40 . 50 and the use of a shape memory alloy).
  • The in the stent 10 integrated heart valve (valve stent) can with the cartridge 100 percutaneously (eg femoral artery or vein), endovascularly or minimally invasively via one or more vessels or directly to the heart, where they are implanted in the mitral ring in an annular manner. Another possibility is to bring the valve stent minimally invasively or percutaneously through the chest wall directly into the left ventricle and then retrograde into the mitral valve position or through the chest wall and left atrium antegrade to the mitral valve position around the stent 10 to position and anchor there. Another possibility is that the mitral valve stent 10 can be implanted on the open thorax with / without heart-lung machine through the left atrium (antegrade) or through the left ventricle (retrograde) into the mitral valve annulus.
  • For better orientation, first in 8th the anatomical conditions in the heart explained in more detail. The stent 10 containing cartridge 100 is inserted through the left atrium LA on antegrade insertion. The mitral valve to be replaced consists of the anterior mitral valve leaflet AMKS and the posterior mitral valve bladder PMKS, which in the left ventricle LV are connected via the tendon threads (Chordae tendineae, CT) to the anterior papillary muscle AP or to the posterior papillary muscle. Finally, the aortic valve AK can be recognized, which runs the risk of being impaired in the function of conventional stents.
  • The length of the cartridge 100 is tuned to that before opening this cartridge 100 (eg in transatrial access) the tip of the cartridge 100 lies in the apex of the left ventricle. How out 9 seen, comes the opening of the cartridge 100 with the mitral valve stent 10 while lying so that when opening the cartridge 100 the proximal-sided, ventricular portion of the valve stent 10 located just below the anterior mitral valve bladder AMKS in the area of the distal Cordae tendineae CT.
  • Then, as in 10 and 11 shown, the proximal support bracket 20 slowly extended so that resistance to the ventricular-distal portion of the mitral valve leaflets AMKS, PMKS arises when the catheter is slowly pulled atrial. With simultaneous visualization control, it is then possible, for example, to start rolling the anterior mitral valve leaflet AMKS. This is done by means of the at least one proximal stent bar 20 ' which has the function of curling itself with the anterior mitral valve sail AMKS and displacing and / or wrapping the sail laterally and basally. Thus, the anterior miter flap sail AMKS is pushed aside and folded.
  • Only then would then the further (medial and distal portion) of the valve stent 10 (with the integrated heart valve, not shown) slowly out of the cartridge 100 rolled, so that the heart valve prosthesis comes to rest in the area of the old annulus.
  • As in 12 and 13 shown serve the distal anchoring elements 30 to anchor in the area of the atrium LA (supravalvular, atrial). This anchorage is also visualized (eg, echo, NMR, fluoroscopy, computed tomography, etc.), so that the exact positioning of the valve stent 10 is reached.
  • 14 shows again in detail how the at least one stent bar 20 ' in the deployed state of the stent 10 fixes the anterior mitral valve leaflet AMKS and allows for natural blood flow without affecting the aortic valve, for example. At the same time, the function of the chordae tendineae CT is preserved. It may involve the section that unfolds in the deployed state of the stent 10 spiraling outwards, a section of the stent strap 20 ' or the entire stent 20 ' be. It is also conceivable that this section is the second section 20b the stent strap 20 ' a particularly preferred embodiment of the stent 10 according to the invention acts.
  • Compared to the known solutions, there is thus the possibility that at least one sail is displaced and partially or completely wrapped / rolled. This is done via the at least one support bracket 20 ' (please refer 14 ), which curls up with the flap sail together. Should not work once and the valve stent 10 can not be positioned exactly, this must be unfolded again and in the cartridge 100 withdrawn and be repositioned.
  • To achieve this displacement and collapse of individual leaflets, it may be that more than one stent 20 ' is needed. At the same time it is also possible to use different actuators for an implantation maneuver, such as Bowden cables, flexible catheters, eyelets or other materials that move with or against each other, so that individual or group-oriented support bracket 20 ' can unfold in time from one another, or roll in / fold in. This independent development / working of partial elements of the stent 10 is necessary to achieve accurate positioning, anchoring and local wrapping of the flap sails AMKS.
  • In order to get a good flow over the new mitral valve and the left ventricular outflow tract, the old valve must be rolled up by means of the proximal stent bars and, in addition, raised to the mitral valve annulus. This happens because after the entire extension of the mitral valve stent 10 the atrial and ventricular portions 20 . 30 of the stent 10 move towards each other and thus re-tension the sutures CT and move the mitral valve leaflets AMKS, PMKS to the annulus.
  • Of the Blood flow from the left atrium via the left ventricle into the aorta ascendens is so free and unhindered possible.
  • to better fixation has e.g. the mitral valve stent a larger angle as 90 ° between the atrial (supravalvular, 30) and the medial (in the middle, between 20 and 30) Stent struts. This dilation of the atrial to the annular and ventricular Promotes 20 stent shares the fixation of the valve stent in the neo-annulus and prevents his migration.

Claims (8)

  1. Foldable mitral valve stent ( 10 ) with a plurality of distally arranged stent bars ( 20 ) and a plurality of proximal anchoring elements ( 30 ), characterized in that the mitral valve stent ( 10 ) at least one, one in the unfolded state of the mitral valve stent ( 10 ) spiraling outwardly curling section forming stent ( 20 ' ) having.
  2. Mitral valve stent ( 10 ) according to claim 1, characterized in that at least one stent ( 20 ) a proximal section ( 20a ) and a distal section ( 20b ), wherein the proximal portion ( 20a ) and the distal section ( 20b ) in the unfolded state occupy an angle smaller than 180 °.
  3. Mitral valve stent ( 10 ) according to one of the preceding claims, characterized in that an anchoring element ( 30 ) and a stent ( 20 ) connecting spring element ( 40 ) is provided.
  4. Mitral valve stent ( 10 ) according to one of the preceding claims, characterized in that a spring element ( 50 ), the first section ( 20a ) and the second section ( 20b ) of the stent-hanger ( 20 ) connects.
  5. Mitral valve stent ( 10 ) according to one of the preceding claims, characterized in that the mitral valve stent ( 10 ) is foldable self-expanding along its longitudinal axis.
  6. Mitral valve stent ( 10 ) according to one of the preceding claims, characterized in that a stent ( 20 ) at least one fastening element ( 60 . 70 ) for connecting the mitral valve stent ( 10 ) with myocardial tissue or between the heart valve and the mitral valve stent ( 10 ) has arranged sealing membrane.
  7. Mitral valve stent ( 10 ) according to one of the preceding claims, characterized in that at least one of the spiraling outwardly curling section forming stent ( 20 ' ) consists of a shape memory alloy.
  8. Mitral valve stent ( 10 ) according to claim 7, characterized in that the shape memory alloy is NiTiNol.
DE200610052564 2006-11-06 2006-11-06 Mitral valve stent for surgical implantation and fixation of heart valve prosthesis to heart, has stent clips arranged distally, where one of stent clips forms section that is externally rolled in unfolded condition of stent Active DE102006052564B3 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE200610052564 DE102006052564B3 (en) 2006-11-06 2006-11-06 Mitral valve stent for surgical implantation and fixation of heart valve prosthesis to heart, has stent clips arranged distally, where one of stent clips forms section that is externally rolled in unfolded condition of stent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE200610052564 DE102006052564B3 (en) 2006-11-06 2006-11-06 Mitral valve stent for surgical implantation and fixation of heart valve prosthesis to heart, has stent clips arranged distally, where one of stent clips forms section that is externally rolled in unfolded condition of stent

Publications (1)

Publication Number Publication Date
DE102006052564B3 true DE102006052564B3 (en) 2007-12-13

Family

ID=38664036

Family Applications (1)

Application Number Title Priority Date Filing Date
DE200610052564 Active DE102006052564B3 (en) 2006-11-06 2006-11-06 Mitral valve stent for surgical implantation and fixation of heart valve prosthesis to heart, has stent clips arranged distally, where one of stent clips forms section that is externally rolled in unfolded condition of stent

Country Status (1)

Country Link
DE (1) DE102006052564B3 (en)

Cited By (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012177942A2 (en) 2011-06-21 2012-12-27 Hanson Gifford, Iii Prosthetic heart valve devices and associated systems and methods
US8398708B2 (en) 2010-03-05 2013-03-19 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic valves
US8449599B2 (en) 2009-12-04 2013-05-28 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
WO2014110023A1 (en) * 2013-01-08 2014-07-17 Medtronic Inc. Valve prosthesis
CN104684505A (en) * 2012-05-20 2015-06-03 戴尔马修墨医学研究内结构和服务有限公司 Prosthetic mitral valve
US9078749B2 (en) 2007-09-13 2015-07-14 Georg Lutter Truncated cone heart valve stent
US9241790B2 (en) 2010-05-05 2016-01-26 Neovasc Tiara Inc. Transcatheter mitral valve prosthesis
US9289291B2 (en) 2009-11-05 2016-03-22 The Trustees Of The University Of Pennsylvania Valve prosthesis
US9295552B2 (en) 2011-10-19 2016-03-29 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US9301840B2 (en) 2008-10-10 2016-04-05 Edwards Lifesciences Corporation Expandable introducer sheath
US9308087B2 (en) 2011-04-28 2016-04-12 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
USD755384S1 (en) 2014-03-05 2016-05-03 Edwards Lifesciences Cardiaq Llc Stent
US9333074B2 (en) 2009-04-15 2016-05-10 Edwards Lifesciences Cardiaq Llc Vascular implant and delivery system
US9345573B2 (en) 2012-05-30 2016-05-24 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US9364354B2 (en) 2000-03-27 2016-06-14 Neovasc Medical Ltd Methods for treating abnormal growths in the body using a flow reducing implant
CN105682611A (en) * 2013-10-28 2016-06-15 坦迪尼控股股份有限公司 Prosthetic heart valve and systems and methods for delivering the same
US9375312B2 (en) 2010-07-09 2016-06-28 Highlife Sas Transcatheter atrio-ventricular valve prosthesis
US9414918B2 (en) 2012-09-06 2016-08-16 Edwards Lifesciences Corporation Heart valve sealing devices
US9421098B2 (en) 2010-12-23 2016-08-23 Twelve, Inc. System for mitral valve repair and replacement
US9433514B2 (en) 2005-11-10 2016-09-06 Edwards Lifesciences Cardiaq Llc Method of securing a prosthesis
US9439763B2 (en) 2013-02-04 2016-09-13 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
US9456896B2 (en) 2008-09-29 2016-10-04 Edwards Lifesciences Cardiaq Llc Body cavity prosthesis
US9480559B2 (en) 2011-08-11 2016-11-01 Tendyne Holdings, Inc. Prosthetic valves and related inventions
US9480560B2 (en) 2009-09-29 2016-11-01 Edwards Lifesciences Cardiaq Llc Method of securing an intralumenal frame assembly
US9486306B2 (en) 2013-04-02 2016-11-08 Tendyne Holdings, Inc. Inflatable annular sealing device for prosthetic mitral valve
US9526611B2 (en) 2013-10-29 2016-12-27 Tendyne Holdings, Inc. Apparatus and methods for delivery of transcatheter prosthetic valves
US9532870B2 (en) 2014-06-06 2017-01-03 Edwards Lifesciences Corporation Prosthetic valve for replacing a mitral valve
US9554897B2 (en) 2011-04-28 2017-01-31 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US9572665B2 (en) 2013-04-04 2017-02-21 Neovasc Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
US9579198B2 (en) 2012-03-01 2017-02-28 Twelve, Inc. Hydraulic delivery systems for prosthetic heart valve devices and associated methods
US9597181B2 (en) 2013-06-25 2017-03-21 Tendyne Holdings, Inc. Thrombus management and structural compliance features for prosthetic heart valves
US9597183B2 (en) 2008-10-01 2017-03-21 Edwards Lifesciences Cardiaq Llc Delivery system for vascular implant
US9610159B2 (en) 2013-05-30 2017-04-04 Tendyne Holdings, Inc. Structural members for prosthetic mitral valves
US9655722B2 (en) 2011-10-19 2017-05-23 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US9662202B2 (en) 2013-10-24 2017-05-30 Medtronic, Inc. Heart valve prosthesis
US9675454B2 (en) 2012-07-30 2017-06-13 Tendyne Holdings, Inc. Delivery systems and methods for transcatheter prosthetic valves
US9681951B2 (en) 2013-03-14 2017-06-20 Edwards Lifesciences Cardiaq Llc Prosthesis with outer skirt and anchors
US9730791B2 (en) 2013-03-14 2017-08-15 Edwards Lifesciences Cardiaq Llc Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery
US9744059B2 (en) 2003-11-19 2017-08-29 Neovasc Medical Ltd. Vascular implant
US9763780B2 (en) 2011-10-19 2017-09-19 Twelve, Inc. Devices, systems and methods for heart valve replacement
EP3231393A1 (en) 2016-04-13 2017-10-18 Christian Vallbracht Minimally invasive implantable mitral and tricuspid valve
US9827092B2 (en) 2011-12-16 2017-11-28 Tendyne Holdings, Inc. Tethers for prosthetic mitral valve
US9895221B2 (en) 2012-07-28 2018-02-20 Tendyne Holdings, Inc. Multi-component designs for heart valve retrieval device, sealing structures and stent assembly
US9901443B2 (en) 2011-10-19 2018-02-27 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
USD815744S1 (en) 2016-04-28 2018-04-17 Edwards Lifesciences Cardiaq Llc Valve frame for a delivery system
US9949827B2 (en) 2009-09-29 2018-04-24 Edwards Lifesciences Cardiaq Llc Replacement heart valves, delivery devices and methods
US9986993B2 (en) 2014-02-11 2018-06-05 Tendyne Holdings, Inc. Adjustable tether and epicardial pad system for prosthetic heart valve
US10004599B2 (en) 2014-02-21 2018-06-26 Edwards Lifesciences Cardiaq Llc Prosthesis, delivery device and methods of use
US10010417B2 (en) 2015-04-16 2018-07-03 Edwards Lifesciences Corporation Low-profile prosthetic heart valve for replacing a mitral valve
US10058424B2 (en) 2014-08-21 2018-08-28 Edwards Lifesciences Corporation Dual-flange prosthetic valve frame
US10064718B2 (en) 2015-04-16 2018-09-04 Edwards Lifesciences Corporation Low-profile prosthetic heart valve for replacing a mitral valve
US10092400B2 (en) 2015-06-23 2018-10-09 Edwards Lifesciences Cardiaq Llc Systems and methods for anchoring and sealing a prosthetic heart valve
US10111747B2 (en) 2013-05-20 2018-10-30 Twelve, Inc. Implantable heart valve devices, mitral valve repair devices and associated systems and methods
US10117744B2 (en) 2015-08-26 2018-11-06 Edwards Lifesciences Cardiaq Llc Replacement heart valves and methods of delivery
US10179044B2 (en) 2014-05-19 2019-01-15 Edwards Lifesciences Cardiaq Llc Replacement mitral valve
US10195026B2 (en) 2014-07-22 2019-02-05 Edwards Lifesciences Corporation Mitral valve anchoring
US10195028B2 (en) 2013-09-10 2019-02-05 Edwards Lifesciences Corporation Magnetic retaining mechanisms for prosthetic valves
US10201419B2 (en) 2014-02-05 2019-02-12 Tendyne Holdings, Inc. Apparatus and methods for transfemoral delivery of prosthetic mitral valve
US10206775B2 (en) 2012-08-13 2019-02-19 Medtronic, Inc. Heart valve prosthesis
US10226334B2 (en) 2008-05-01 2019-03-12 Edwards Lifesciences Corporation Method for replacing mitral valve
US10226335B2 (en) 2015-06-22 2019-03-12 Edwards Lifesciences Cardiaq Llc Actively controllable heart valve implant and method of controlling same
US10238490B2 (en) 2015-08-21 2019-03-26 Twelve, Inc. Implant heart valve devices, mitral valve repair devices and associated systems and methods
US10265172B2 (en) 2016-04-29 2019-04-23 Medtronic Vascular, Inc. Prosthetic heart valve devices with tethered anchors and associated systems and methods
US10327894B2 (en) 2015-09-18 2019-06-25 Tendyne Holdings, Inc. Methods for delivery of prosthetic mitral valves
US10350062B2 (en) 2016-07-21 2019-07-16 Edwards Lifesciences Corporation Replacement heart valve prosthesis
US10350065B2 (en) 2006-07-28 2019-07-16 Edwards Lifesciences Cardiaq Llc Percutaneous valve prosthesis and system and method for implanting the same
US10350066B2 (en) 2015-08-28 2019-07-16 Edwards Lifesciences Cardiaq Llc Steerable delivery system for replacement mitral valve and methods of use
US10376363B2 (en) 2015-04-30 2019-08-13 Edwards Lifesciences Cardiaq Llc Replacement mitral valve, delivery system for replacement mitral valve and methods of use
US10376364B2 (en) 2015-11-10 2019-08-13 Edwards Lifesciences Corporation Implant delivery capsule
US10433961B2 (en) 2017-04-18 2019-10-08 Twelve, Inc. Delivery systems with tethers for prosthetic heart valve devices and associated methods
US10441416B2 (en) 2015-04-21 2019-10-15 Edwards Lifesciences Corporation Percutaneous mitral valve replacement device
US10463489B2 (en) 2013-04-02 2019-11-05 Tendyne Holdings, Inc. Prosthetic heart valve and systems and methods for delivering the same
US10470877B2 (en) 2016-05-03 2019-11-12 Tendyne Holdings, Inc. Apparatus and methods for anterior valve leaflet management
US10470876B2 (en) 2015-11-10 2019-11-12 Edwards Lifesciences Corporation Transcatheter heart valve for replacing natural mitral valve
US10478293B2 (en) 2013-04-04 2019-11-19 Tendyne Holdings, Inc. Retrieval and repositioning system for prosthetic heart valve
US10485660B2 (en) 2010-06-21 2019-11-26 Edwards Lifesciences Cardiaq Llc Replacement heart valve
US10500038B1 (en) 2011-05-20 2019-12-10 Tel Hashomer Medical Research Infrastructure And Services Ltd. Prosthetic mitral valve, and methods and devices for deploying the prosthetic mitral valve
US10517728B2 (en) 2014-03-10 2019-12-31 Tendyne Holdings, Inc. Devices and methods for positioning and monitoring tether load for prosthetic mitral valve
US10555718B2 (en) 2013-10-17 2020-02-11 Tendyne Holdings, Inc. Apparatus and methods for alignment and deployment of intracardiac devices
US10575950B2 (en) 2017-04-18 2020-03-03 Twelve, Inc. Hydraulic systems for delivering prosthetic heart valve devices and associated methods
US10575951B2 (en) 2015-08-26 2020-03-03 Edwards Lifesciences Cardiaq Llc Delivery device and methods of use for transapical delivery of replacement mitral valve
US10583000B2 (en) 2013-03-14 2020-03-10 Edwards Lifesciences Cardiaq Llc Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery
US10583002B2 (en) 2013-03-11 2020-03-10 Neovasc Tiara Inc. Prosthetic valve with anti-pivoting mechanism
US10610358B2 (en) 2015-12-28 2020-04-07 Tendyne Holdings, Inc. Atrial pocket closures for prosthetic heart valves
US10610356B2 (en) 2015-02-05 2020-04-07 Tendyne Holdings, Inc. Expandable epicardial pads and devices and methods for delivery of same
US10610354B2 (en) 2013-08-01 2020-04-07 Tendyne Holdings, Inc. Epicardial anchor devices and methods
US10639143B2 (en) 2016-08-26 2020-05-05 Edwards Lifesciences Corporation Multi-portion replacement heart valve prosthesis
US10646338B2 (en) 2017-06-02 2020-05-12 Twelve, Inc. Delivery systems with telescoping capsules for deploying prosthetic heart valve devices and associated methods
US10646340B2 (en) 2016-08-19 2020-05-12 Edwards Lifesciences Corporation Steerable delivery system for replacement mitral valve
US10667905B2 (en) 2015-04-16 2020-06-02 Tendyne Holdings, Inc. Apparatus and methods for delivery, repositioning, and retrieval of transcatheter prosthetic valves
US10702378B2 (en) 2017-04-18 2020-07-07 Twelve, Inc. Prosthetic heart valve device and associated systems and methods
US10702380B2 (en) 2011-10-19 2020-07-07 Twelve, Inc. Devices, systems and methods for heart valve replacement
US10709591B2 (en) 2017-06-06 2020-07-14 Twelve, Inc. Crimping device and method for loading stents and prosthetic heart valves
US10729541B2 (en) 2017-07-06 2020-08-04 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US10758348B2 (en) 2016-11-02 2020-09-01 Edwards Lifesciences Corporation Supra and sub-annular mitral valve delivery system
US10786351B2 (en) 2015-01-07 2020-09-29 Tendyne Holdings, Inc. Prosthetic mitral valves and apparatus and methods for delivery of same
US10786352B2 (en) 2017-07-06 2020-09-29 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US10792151B2 (en) 2017-05-11 2020-10-06 Twelve, Inc. Delivery systems for delivering prosthetic heart valve devices and associated methods
US10813757B2 (en) 2017-07-06 2020-10-27 Edwards Lifesciences Corporation Steerable rail delivery system
US10820996B2 (en) 2019-02-11 2020-11-03 Twelve, Inc. Implantable heart valve devices, mitral valve repair devices and associated systems and methods

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10010074A1 (en) * 2000-02-28 2001-10-18 Fraunhofer Ges Forschung Device for fastening and anchoring heart valve prostheses
DE19546692C2 (en) * 1995-12-14 2002-11-07 Hans-Reiner Figulla Self-expanding heart valve prosthesis for implantation in the human body via a catheter system
EP1469797B1 (en) * 2002-08-13 2005-11-02 Markus Ferrari Device for the implantation and fixing of heart valve prostheses

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19546692C2 (en) * 1995-12-14 2002-11-07 Hans-Reiner Figulla Self-expanding heart valve prosthesis for implantation in the human body via a catheter system
DE10010074A1 (en) * 2000-02-28 2001-10-18 Fraunhofer Ges Forschung Device for fastening and anchoring heart valve prostheses
EP1469797B1 (en) * 2002-08-13 2005-11-02 Markus Ferrari Device for the implantation and fixing of heart valve prostheses

Cited By (187)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9364354B2 (en) 2000-03-27 2016-06-14 Neovasc Medical Ltd Methods for treating abnormal growths in the body using a flow reducing implant
US10542994B2 (en) 2000-03-27 2020-01-28 Neovasc Medical Ltd. Methods for treating abnormal growths in the body using a flow reducing implant
US9744059B2 (en) 2003-11-19 2017-08-29 Neovasc Medical Ltd. Vascular implant
US10456277B2 (en) 2005-11-10 2019-10-29 Edwards Lifesciences Cardiaq Llc Percutaneous heart valve
US9974669B2 (en) 2005-11-10 2018-05-22 Edwards Lifesciences Cardiaq Llc Percutaneous heart valve
US9486336B2 (en) 2005-11-10 2016-11-08 Edwards Lifesciences Cardiaq Llc Prosthesis having a plurality of distal and proximal prongs
US9433514B2 (en) 2005-11-10 2016-09-06 Edwards Lifesciences Cardiaq Llc Method of securing a prosthesis
US10350065B2 (en) 2006-07-28 2019-07-16 Edwards Lifesciences Cardiaq Llc Percutaneous valve prosthesis and system and method for implanting the same
US9078749B2 (en) 2007-09-13 2015-07-14 Georg Lutter Truncated cone heart valve stent
US9095433B2 (en) 2007-09-13 2015-08-04 Georg Lutter Truncated cone heart valve stent
US10456248B2 (en) 2007-09-13 2019-10-29 Georg Lutter Truncated cone heart valve stent
US9730792B2 (en) 2007-09-13 2017-08-15 Georg Lutter Truncated cone heart valve stent
US9254192B2 (en) 2007-09-13 2016-02-09 Georg Lutter Truncated cone heart valve stent
US10226334B2 (en) 2008-05-01 2019-03-12 Edwards Lifesciences Corporation Method for replacing mitral valve
US10617520B2 (en) 2008-05-01 2020-04-14 Edwards Lifesciences Corporation Method of replacing mitral valve
US10149756B2 (en) 2008-09-29 2018-12-11 Edwards Lifesciences Cardiaq Llc Heart valve
US9456896B2 (en) 2008-09-29 2016-10-04 Edwards Lifesciences Cardiaq Llc Body cavity prosthesis
US10646334B2 (en) 2008-09-29 2020-05-12 Edwards Lifesciences Cardiaq Llc Heart valve
US9597183B2 (en) 2008-10-01 2017-03-21 Edwards Lifesciences Cardiaq Llc Delivery system for vascular implant
US9301840B2 (en) 2008-10-10 2016-04-05 Edwards Lifesciences Corporation Expandable introducer sheath
US9339379B2 (en) 2009-04-15 2016-05-17 Edwards Lifesciences Cardiaq Llc Vascular implant and delivery system
US10441412B2 (en) 2009-04-15 2019-10-15 Edwards Lifesciences Cardiaq Llc Vascular implant and delivery system
US9585747B2 (en) 2009-04-15 2017-03-07 Edwards Lifesciences Cardiaq Llc Vascular implant
US9339380B2 (en) 2009-04-15 2016-05-17 Edwards Lifesciences Cardiaq Llc Vascular implant
US9333074B2 (en) 2009-04-15 2016-05-10 Edwards Lifesciences Cardiaq Llc Vascular implant and delivery system
US9333073B2 (en) 2009-04-15 2016-05-10 Edwards Lifesciences Cardiaq Llc Vascular implant and delivery method
US9339378B2 (en) 2009-04-15 2016-05-17 Edwards Lifesciences Cardiaq Llc Vascular implant and delivery system
US9730790B2 (en) 2009-09-29 2017-08-15 Edwards Lifesciences Cardiaq Llc Replacement valve and method
US10166097B2 (en) 2009-09-29 2019-01-01 Edwards Lifesciences Cardiaq Llc Replacement heart valve and method
US9949827B2 (en) 2009-09-29 2018-04-24 Edwards Lifesciences Cardiaq Llc Replacement heart valves, delivery devices and methods
US10524901B2 (en) 2009-09-29 2020-01-07 Edwards Lifesciences Cardiaq Llc Replacement heart valve
US9480560B2 (en) 2009-09-29 2016-11-01 Edwards Lifesciences Cardiaq Llc Method of securing an intralumenal frame assembly
US9289291B2 (en) 2009-11-05 2016-03-22 The Trustees Of The University Of Pennsylvania Valve prosthesis
US9717591B2 (en) 2009-12-04 2017-08-01 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
US8449599B2 (en) 2009-12-04 2013-05-28 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
US9084676B2 (en) 2009-12-04 2015-07-21 Edwards Lifesciences Corporation Apparatus for treating a mitral valve
US8986373B2 (en) 2009-12-04 2015-03-24 Edwards Lifesciences Corporation Method for implanting a prosthetic mitral valve
US8926691B2 (en) 2009-12-04 2015-01-06 Edwards Lifesciences Corporation Apparatus for treating a mitral valve
US9433500B2 (en) 2009-12-04 2016-09-06 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
US10568736B2 (en) 2010-03-05 2020-02-25 Edward Lifesciences Corporation Retaining mechanisms for prosthetic valves
US10130464B2 (en) 2010-03-05 2018-11-20 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic valves
US9370420B2 (en) 2010-03-05 2016-06-21 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic valves
US8398708B2 (en) 2010-03-05 2013-03-19 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic valves
US9241790B2 (en) 2010-05-05 2016-01-26 Neovasc Tiara Inc. Transcatheter mitral valve prosthesis
US10449042B2 (en) 2010-05-05 2019-10-22 Neovasc Tiara Inc. Transcatheter mitral valve prosthesis
US9248014B2 (en) 2010-05-05 2016-02-02 Neovasc Tiara Inc. Transcatheter mitral valve prosthesis
US9770329B2 (en) 2010-05-05 2017-09-26 Neovasc Tiara Inc. Transcatheter mitral valve prosthesis
US10639146B2 (en) 2010-06-21 2020-05-05 Edwards Lifesciences Cardiaq Llc Replacement heart valve
US10485660B2 (en) 2010-06-21 2019-11-26 Edwards Lifesciences Cardiaq Llc Replacement heart valve
US9931206B2 (en) 2010-07-09 2018-04-03 Highlife Sas Transcatheter atrio-ventricular valve prosthesis
US9375312B2 (en) 2010-07-09 2016-06-28 Highlife Sas Transcatheter atrio-ventricular valve prosthesis
US10610362B2 (en) 2010-09-23 2020-04-07 Edwards Lifesciences Cardiaq Llc Replacement heart valves, delivery devices and methods
US9421098B2 (en) 2010-12-23 2016-08-23 Twelve, Inc. System for mitral valve repair and replacement
US10517725B2 (en) 2010-12-23 2019-12-31 Twelve, Inc. System for mitral valve repair and replacement
US10779938B2 (en) 2011-02-23 2020-09-22 Edwards Lifesciences Cardiaq Llc Replacement heart valve and method
US9713529B2 (en) 2011-04-28 2017-07-25 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US9554897B2 (en) 2011-04-28 2017-01-31 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US9308087B2 (en) 2011-04-28 2016-04-12 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US10500038B1 (en) 2011-05-20 2019-12-10 Tel Hashomer Medical Research Infrastructure And Services Ltd. Prosthetic mitral valve, and methods and devices for deploying the prosthetic mitral valve
JP2018020246A (en) * 2011-06-21 2018-02-08 トゥエルヴ, インコーポレイテッド Prosthetic treatment device
AU2012272855B2 (en) * 2011-06-21 2017-06-15 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US10751173B2 (en) 2011-06-21 2020-08-25 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US10028827B2 (en) 2011-06-21 2018-07-24 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US9585751B2 (en) 2011-06-21 2017-03-07 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
EP2723273A2 (en) * 2011-06-21 2014-04-30 Foundry Newco XII, Inc. Prosthetic heart valve devices and associated systems and methods
EP2723273A4 (en) * 2011-06-21 2014-12-03 Foundry Newco Xii Inc Prosthetic heart valve devices and associated systems and methods
WO2012177942A2 (en) 2011-06-21 2012-12-27 Hanson Gifford, Iii Prosthetic heart valve devices and associated systems and methods
US9579196B2 (en) 2011-06-21 2017-02-28 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
JP2016047481A (en) * 2011-06-21 2016-04-07 トゥエルヴ, インコーポレイテッド Prosthetic treatment device
US10034750B2 (en) 2011-06-21 2018-07-31 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US9572662B2 (en) 2011-06-21 2017-02-21 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
CN103997990A (en) * 2011-06-21 2014-08-20 托尔福公司 Prosthetic heart valve devices and associated systems and methods
AU2012272855C1 (en) * 2011-06-21 2018-04-05 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
CN107496054A (en) * 2011-06-21 2017-12-22 托尔福公司 Artificial heart valve film device and related system and method
JP2014522678A (en) * 2011-06-21 2014-09-08 トゥエルヴ, インコーポレイテッド Prosthetic heart valve device and related systems and methods
AU2017228689B2 (en) * 2011-06-21 2019-06-06 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US10617519B2 (en) 2011-08-11 2020-04-14 Tendyne Holdings, Inc. Prosthetic valves and related inventions
US10639145B2 (en) 2011-08-11 2020-05-05 Tendyne Holdings, Inc. Prosthetic valves and related inventions
US9480559B2 (en) 2011-08-11 2016-11-01 Tendyne Holdings, Inc. Prosthetic valves and related inventions
US9833315B2 (en) 2011-08-11 2017-12-05 Tendyne Holdings, Inc. Prosthetic valves and related inventions
US10052204B2 (en) 2011-10-19 2018-08-21 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US10299927B2 (en) 2011-10-19 2019-05-28 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US9763780B2 (en) 2011-10-19 2017-09-19 Twelve, Inc. Devices, systems and methods for heart valve replacement
US10335278B2 (en) 2011-10-19 2019-07-02 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US10299917B2 (en) 2011-10-19 2019-05-28 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US9901443B2 (en) 2011-10-19 2018-02-27 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US9295552B2 (en) 2011-10-19 2016-03-29 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US9655722B2 (en) 2011-10-19 2017-05-23 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US10702380B2 (en) 2011-10-19 2020-07-07 Twelve, Inc. Devices, systems and methods for heart valve replacement
US10016271B2 (en) 2011-10-19 2018-07-10 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US10537422B2 (en) 2011-11-23 2020-01-21 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US9827092B2 (en) 2011-12-16 2017-11-28 Tendyne Holdings, Inc. Tethers for prosthetic mitral valve
US10363133B2 (en) 2012-02-14 2019-07-30 Neovac Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US9579198B2 (en) 2012-03-01 2017-02-28 Twelve, Inc. Hydraulic delivery systems for prosthetic heart valve devices and associated methods
US10258468B2 (en) 2012-03-01 2019-04-16 Twelve, Inc. Hydraulic delivery systems for prosthetic heart valve devices and associated methods
US10292816B2 (en) 2012-05-20 2019-05-21 Tel Hashomer Medical Research Infrastructure And Services Ltd. Prosthetic mitral valve
CN104684505A (en) * 2012-05-20 2015-06-03 戴尔马修墨医学研究内结构和服务有限公司 Prosthetic mitral valve
US10016275B2 (en) 2012-05-30 2018-07-10 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US10314705B2 (en) 2012-05-30 2019-06-11 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US9345573B2 (en) 2012-05-30 2016-05-24 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US9895221B2 (en) 2012-07-28 2018-02-20 Tendyne Holdings, Inc. Multi-component designs for heart valve retrieval device, sealing structures and stent assembly
US9675454B2 (en) 2012-07-30 2017-06-13 Tendyne Holdings, Inc. Delivery systems and methods for transcatheter prosthetic valves
US10219900B2 (en) 2012-07-30 2019-03-05 Tendyne Holdings, Inc. Delivery systems and methods for transcatheter prosthetic valves
US10206775B2 (en) 2012-08-13 2019-02-19 Medtronic, Inc. Heart valve prosthesis
US9510946B2 (en) 2012-09-06 2016-12-06 Edwards Lifesciences Corporation Heart valve sealing devices
US9414918B2 (en) 2012-09-06 2016-08-16 Edwards Lifesciences Corporation Heart valve sealing devices
US9907652B2 (en) 2012-09-06 2018-03-06 Edwards Lifesciences Corporation Heart valve sealing devices
US9867698B2 (en) 2013-01-08 2018-01-16 Medtronic, Inc. Valve prosthesis and method for delivery
US9232995B2 (en) 2013-01-08 2016-01-12 Medtronic, Inc. Valve prosthesis and method for delivery
WO2014110023A1 (en) * 2013-01-08 2014-07-17 Medtronic Inc. Valve prosthesis
US10799347B1 (en) 2013-02-04 2020-10-13 Edwards Lifesciences Corporation Prosthetic heart valve with atrial sealing member
US10463481B2 (en) 2013-02-04 2019-11-05 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
US9439763B2 (en) 2013-02-04 2016-09-13 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
US10583002B2 (en) 2013-03-11 2020-03-10 Neovasc Tiara Inc. Prosthetic valve with anti-pivoting mechanism
US10583000B2 (en) 2013-03-14 2020-03-10 Edwards Lifesciences Cardiaq Llc Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery
US9730791B2 (en) 2013-03-14 2017-08-15 Edwards Lifesciences Cardiaq Llc Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery
US9681951B2 (en) 2013-03-14 2017-06-20 Edwards Lifesciences Cardiaq Llc Prosthesis with outer skirt and anchors
US10716664B2 (en) 2013-03-14 2020-07-21 Edwards Lifesciences Cardiaq Llc Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery
US9486306B2 (en) 2013-04-02 2016-11-08 Tendyne Holdings, Inc. Inflatable annular sealing device for prosthetic mitral valve
US10463489B2 (en) 2013-04-02 2019-11-05 Tendyne Holdings, Inc. Prosthetic heart valve and systems and methods for delivering the same
US10463494B2 (en) 2013-04-02 2019-11-05 Tendyne Holdings, Inc. Prosthetic heart valve and systems and methods for delivering the same
US10383728B2 (en) 2013-04-04 2019-08-20 Neovasc Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
US9572665B2 (en) 2013-04-04 2017-02-21 Neovasc Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
US10478293B2 (en) 2013-04-04 2019-11-19 Tendyne Holdings, Inc. Retrieval and repositioning system for prosthetic heart valve
US10111747B2 (en) 2013-05-20 2018-10-30 Twelve, Inc. Implantable heart valve devices, mitral valve repair devices and associated systems and methods
US9610159B2 (en) 2013-05-30 2017-04-04 Tendyne Holdings, Inc. Structural members for prosthetic mitral valves
US10405976B2 (en) 2013-05-30 2019-09-10 Tendyne Holdings, Inc. Structural members for prosthetic mitral valves
US9597181B2 (en) 2013-06-25 2017-03-21 Tendyne Holdings, Inc. Thrombus management and structural compliance features for prosthetic heart valves
US10595996B2 (en) 2013-06-25 2020-03-24 Tendyne Holdings, Inc. Thrombus management and structural compliance features for prosthetic heart valves
US10610354B2 (en) 2013-08-01 2020-04-07 Tendyne Holdings, Inc. Epicardial anchor devices and methods
US10195028B2 (en) 2013-09-10 2019-02-05 Edwards Lifesciences Corporation Magnetic retaining mechanisms for prosthetic valves
US10555718B2 (en) 2013-10-17 2020-02-11 Tendyne Holdings, Inc. Apparatus and methods for alignment and deployment of intracardiac devices
US9662202B2 (en) 2013-10-24 2017-05-30 Medtronic, Inc. Heart valve prosthesis
US10543079B2 (en) 2013-10-24 2020-01-28 Medtronic, Inc. Heart valve prosthesis
CN105682611B (en) * 2013-10-28 2018-06-01 坦迪尼控股股份有限公司 Prosthetic heart valve and the system and method for conveying prosthetic heart valve
CN108403261A (en) * 2013-10-28 2018-08-17 坦迪尼控股股份有限公司 Prosthetic heart valve and system and method for conveying prosthetic heart valve
CN105682611A (en) * 2013-10-28 2016-06-15 坦迪尼控股股份有限公司 Prosthetic heart valve and systems and methods for delivering the same
US10363135B2 (en) 2013-10-29 2019-07-30 Tendyne Holdings, Inc. Apparatus and methods for delivery of transcatheter prosthetic valves
US9526611B2 (en) 2013-10-29 2016-12-27 Tendyne Holdings, Inc. Apparatus and methods for delivery of transcatheter prosthetic valves
US10201419B2 (en) 2014-02-05 2019-02-12 Tendyne Holdings, Inc. Apparatus and methods for transfemoral delivery of prosthetic mitral valve
US9986993B2 (en) 2014-02-11 2018-06-05 Tendyne Holdings, Inc. Adjustable tether and epicardial pad system for prosthetic heart valve
US10004599B2 (en) 2014-02-21 2018-06-26 Edwards Lifesciences Cardiaq Llc Prosthesis, delivery device and methods of use
USD755384S1 (en) 2014-03-05 2016-05-03 Edwards Lifesciences Cardiaq Llc Stent
US10517728B2 (en) 2014-03-10 2019-12-31 Tendyne Holdings, Inc. Devices and methods for positioning and monitoring tether load for prosthetic mitral valve
US10179044B2 (en) 2014-05-19 2019-01-15 Edwards Lifesciences Cardiaq Llc Replacement mitral valve
US9532870B2 (en) 2014-06-06 2017-01-03 Edwards Lifesciences Corporation Prosthetic valve for replacing a mitral valve
US10687939B2 (en) 2014-06-06 2020-06-23 Edwards Lifesciences Corporation Prosthetic valve for replacing a mitral valve
US10010414B2 (en) 2014-06-06 2018-07-03 Edwards Lifesciences Corporation Prosthetic valve for replacing a mitral valve
US10195026B2 (en) 2014-07-22 2019-02-05 Edwards Lifesciences Corporation Mitral valve anchoring
US10058424B2 (en) 2014-08-21 2018-08-28 Edwards Lifesciences Corporation Dual-flange prosthetic valve frame
US10786351B2 (en) 2015-01-07 2020-09-29 Tendyne Holdings, Inc. Prosthetic mitral valves and apparatus and methods for delivery of same
US10610356B2 (en) 2015-02-05 2020-04-07 Tendyne Holdings, Inc. Expandable epicardial pads and devices and methods for delivery of same
US10010417B2 (en) 2015-04-16 2018-07-03 Edwards Lifesciences Corporation Low-profile prosthetic heart valve for replacing a mitral valve
US10624736B2 (en) 2015-04-16 2020-04-21 Edwards Lifesciences Corporation Low-profile prosthetic heart valve for replacing a mitral valve
US10064718B2 (en) 2015-04-16 2018-09-04 Edwards Lifesciences Corporation Low-profile prosthetic heart valve for replacing a mitral valve
US10667905B2 (en) 2015-04-16 2020-06-02 Tendyne Holdings, Inc. Apparatus and methods for delivery, repositioning, and retrieval of transcatheter prosthetic valves
US10441416B2 (en) 2015-04-21 2019-10-15 Edwards Lifesciences Corporation Percutaneous mitral valve replacement device
US10376363B2 (en) 2015-04-30 2019-08-13 Edwards Lifesciences Cardiaq Llc Replacement mitral valve, delivery system for replacement mitral valve and methods of use
US10226335B2 (en) 2015-06-22 2019-03-12 Edwards Lifesciences Cardiaq Llc Actively controllable heart valve implant and method of controlling same
US10092400B2 (en) 2015-06-23 2018-10-09 Edwards Lifesciences Cardiaq Llc Systems and methods for anchoring and sealing a prosthetic heart valve
US10238490B2 (en) 2015-08-21 2019-03-26 Twelve, Inc. Implant heart valve devices, mitral valve repair devices and associated systems and methods
US10117744B2 (en) 2015-08-26 2018-11-06 Edwards Lifesciences Cardiaq Llc Replacement heart valves and methods of delivery
US10758345B2 (en) 2015-08-26 2020-09-01 Edwards Lifesciences Cardiaq Llc Replacement heart valves and methods of delivery
US10575951B2 (en) 2015-08-26 2020-03-03 Edwards Lifesciences Cardiaq Llc Delivery device and methods of use for transapical delivery of replacement mitral valve
US10350066B2 (en) 2015-08-28 2019-07-16 Edwards Lifesciences Cardiaq Llc Steerable delivery system for replacement mitral valve and methods of use
US10327894B2 (en) 2015-09-18 2019-06-25 Tendyne Holdings, Inc. Methods for delivery of prosthetic mitral valves
US10376364B2 (en) 2015-11-10 2019-08-13 Edwards Lifesciences Corporation Implant delivery capsule
US10470876B2 (en) 2015-11-10 2019-11-12 Edwards Lifesciences Corporation Transcatheter heart valve for replacing natural mitral valve
US10610358B2 (en) 2015-12-28 2020-04-07 Tendyne Holdings, Inc. Atrial pocket closures for prosthetic heart valves
EP3231393A1 (en) 2016-04-13 2017-10-18 Christian Vallbracht Minimally invasive implantable mitral and tricuspid valve
USD815744S1 (en) 2016-04-28 2018-04-17 Edwards Lifesciences Cardiaq Llc Valve frame for a delivery system
US10265172B2 (en) 2016-04-29 2019-04-23 Medtronic Vascular, Inc. Prosthetic heart valve devices with tethered anchors and associated systems and methods
US10470877B2 (en) 2016-05-03 2019-11-12 Tendyne Holdings, Inc. Apparatus and methods for anterior valve leaflet management
US10350062B2 (en) 2016-07-21 2019-07-16 Edwards Lifesciences Corporation Replacement heart valve prosthesis
US10646340B2 (en) 2016-08-19 2020-05-12 Edwards Lifesciences Corporation Steerable delivery system for replacement mitral valve
US10639143B2 (en) 2016-08-26 2020-05-05 Edwards Lifesciences Corporation Multi-portion replacement heart valve prosthesis
US10758348B2 (en) 2016-11-02 2020-09-01 Edwards Lifesciences Corporation Supra and sub-annular mitral valve delivery system
US10702378B2 (en) 2017-04-18 2020-07-07 Twelve, Inc. Prosthetic heart valve device and associated systems and methods
US10433961B2 (en) 2017-04-18 2019-10-08 Twelve, Inc. Delivery systems with tethers for prosthetic heart valve devices and associated methods
US10575950B2 (en) 2017-04-18 2020-03-03 Twelve, Inc. Hydraulic systems for delivering prosthetic heart valve devices and associated methods
US10792151B2 (en) 2017-05-11 2020-10-06 Twelve, Inc. Delivery systems for delivering prosthetic heart valve devices and associated methods
US10646338B2 (en) 2017-06-02 2020-05-12 Twelve, Inc. Delivery systems with telescoping capsules for deploying prosthetic heart valve devices and associated methods
US10709591B2 (en) 2017-06-06 2020-07-14 Twelve, Inc. Crimping device and method for loading stents and prosthetic heart valves
US10729541B2 (en) 2017-07-06 2020-08-04 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US10786352B2 (en) 2017-07-06 2020-09-29 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US10813757B2 (en) 2017-07-06 2020-10-27 Edwards Lifesciences Corporation Steerable rail delivery system
US10820996B2 (en) 2019-02-11 2020-11-03 Twelve, Inc. Implantable heart valve devices, mitral valve repair devices and associated systems and methods

Similar Documents

Publication Publication Date Title
US10799346B2 (en) Methods for quickly implanting a prosthetic heart valve
US10413412B2 (en) Methods and apparatus for endovascularly replacing a heart valve
US10507106B2 (en) Aortic insufficiency repair device and method
US9931207B2 (en) Methods of implanting a heart valve at an aortic annulus
JP6463706B2 (en) Transcatheter prosthetic mitral valve
JP2020075161A (en) Prosthetic heart valve devices
US20180071123A1 (en) System for deploying an endoluminal prosthesis at a surgical site
US10398546B2 (en) Mitral prosthesis and methods for implantation
CN105283149B (en) Prosthetic valve with anti-pivot
US10111747B2 (en) Implantable heart valve devices, mitral valve repair devices and associated systems and methods
US20190282364A1 (en) Systems and methods for transcatheter treatment of valve regurgitation
US8834561B2 (en) Device for the implantation and fixation of prosthetic valves
CN105997305B (en) Method and apparatus for making valve prosthesis be engaged with tissue
ES2755938T3 (en) Prosthetic device for a heart valve
US20160220358A1 (en) Delivery Tool For Percutaneous Delivery Of A Prosthesis
US10456248B2 (en) Truncated cone heart valve stent
JP6049761B2 (en) Mitral valve docking device, system, and method
CN104394799B (en) Stoppers to prevent graft material slippage in a closed web stent-graft
JP2017109140A (en) Stent for positioning and anchoring of valvular prosthesis in implantation site in heart of patient
US9427308B2 (en) Debranching visceral stent graft and methods for use
US9375210B2 (en) Apical puncture access and closure system
US20170296334A1 (en) System and method for placing a percutaneous valve device
US9138313B2 (en) Percutaneous aortic valve
JP5667544B2 (en) Delivery system and method for automatically centering the proximal end of a stent graft
US9326852B2 (en) Method for implanting prosthetic valve

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
R119 Application deemed withdrawn, or ip right lapsed, due to non-payment of renewal fee

Effective date: 20110601

Effective date: 20110531

R073 Re-establishment requested
R082 Change of representative

Representative=s name: PATENTANWAELTE WESTPHAL MUSSGNUG & PARTNER, DE

Representative=s name: WESTPHAL, MUSSGNUG & PARTNER PATENTANWAELTE MI, DE

R124 Re-establishment decision now final