US20210153503A1 - A stable liquid agrochemical formulation - Google Patents

A stable liquid agrochemical formulation Download PDF

Info

Publication number
US20210153503A1
US20210153503A1 US17/258,525 US201917258525A US2021153503A1 US 20210153503 A1 US20210153503 A1 US 20210153503A1 US 201917258525 A US201917258525 A US 201917258525A US 2021153503 A1 US2021153503 A1 US 2021153503A1
Authority
US
United States
Prior art keywords
formulation
liquid agrochemical
agrochemical formulation
stable liquid
active ingredient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
US17/258,525
Other languages
English (en)
Inventor
Prakash Mahadev Jadhav
Jody Candelmo
Jaidev Rajnikant Shroff
Vikram Rajnikant Shroff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UPL Ltd
Original Assignee
UPL Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UPL Ltd filed Critical UPL Ltd
Publication of US20210153503A1 publication Critical patent/US20210153503A1/en
Assigned to UPL LTD reassignment UPL LTD ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: CANDELMO, Jody, JADHAV, PRAKASH MAHADEV, SHROFF, JAIDEV RAJNIKANT, SHROFF, VIKRAM RAJNIKANT
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/22—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P7/00—Arthropodicides
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N27/00—Biocides, pest repellants or attractants, or plant growth regulators containing hydrocarbons
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N53/00—Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof

Definitions

  • the present invention relates to a stable liquid agrochemical formulation.
  • the present invention more particularly relates to a stable liquid agrochemical formulation of more than one active ingredients in the form of an oil dispersion.
  • Agrochemical formulations are generally designed based on customer need and the physiochemical properties of the active ingredient(s). Liquid formulations are generally preferred over solid formulations by customers due to their ease of handling in measuring, pumping, diluting and spraying operations.
  • Oil dispersions are one type of liquid formulation and are defined as stable suspensions of active ingredients in a water-immiscible fluid which may contain other dissolved active ingredients and is intended for dilution with water before use.
  • OD allows the formulation of active ingredients in solid suspended form, which ingredients cannot be formulated in water because of hydrolytic instability.
  • OD formulations have been the subject of studies by companies and formulators because of their advantages with respect to the agronomic performance in the field.
  • oil dispersion formulations are very suitable for the following scenarios: (1) water sensitive active ingredients, 2) compatibility issues with active ingredient mixtures and 3) the need for build-in adjuvancy.
  • the basic components of an agrochemical OD formulation are the solvent or oil phase and the dispersed solid phase. These basic components may include active ingredients, and agrochemically acceptable excipients such as petroleum or naturally derived solvents, safeners, rheology additives, emulsifiers, dispersants and other co-formulants that help deliver the desired attributes of the product.
  • agrochemically acceptable excipients such as petroleum or naturally derived solvents, safeners, rheology additives, emulsifiers, dispersants and other co-formulants that help deliver the desired attributes of the product.
  • OD formulations A technical challenge in the preparation of OD formulations is their preparation process per se, since the active ingredient suspended in oil phase requires dispersing agents to stabilize the system. An indication that dispersants are not acting as expected is the large increase in viscosity of the formulation during milling leading to flocculation which is simply undesirable.
  • an OD formulation may exhibit sedimentation of the active ingredient particles over time into a hard-packed non-redispersible layer or settling of the particles into the lower layers of the liquid column leading to the appearance of phase separation. This phenomenon is commonly known as “syneresis”.
  • US20160088835A1 discloses an agrochemical oil dispersion comprising an active ingredient suspended in oil phase, dispersants, clay based rheological modifiers and emulsifying agents.
  • the disclosed OD formulation achieved stability by incorporating dispersants and clay based rheological modifiers that prevents sedimentation of active ingredients suspended in the oil phase.
  • the drawback of this prior art is that clay based rheological modifiers are prone to suspensibility drop over the period of time leading to phase separation.
  • Chinese Patent Application 102986718A discloses high-concentration oil-based pesticide preparation comprising acetamiprid, bifenthrin and suitable dispersant, penetrant, thickening agent, antifreezing agent, defoaming agent and vegetable oil.
  • the disclosed formulation offers small packing dosage with significantly improved pesticide efficacy and reduced harm to a pesticide user.
  • the process describe in this patent is not meant for bulk manufacturing.
  • US2008312290 discloses an oil based suspension concentrate of sparingly soluble active substance and a moderately soluble active substance which is present in a higher concentration than the solubility limit in the formulation.
  • the disclosed formulation comprises a room-temperature-solid active substance from the class of neonicotinoids, a room-temperature-solid active substance from the class of pyrethroids, penetrant, vegetable oil, cyclohexanone, anionic and non-ionic surfactant and one or more additive selected from the group consisting of emulsifiers, foam inhibitors, preservative, antioxidants, spreaders, colorants and a thickener.
  • the stability of such formulation in low temperature is unaddressed.
  • Another object of the present invention is to provide a process of obtaining a stable liquid agrochemical formulation of neonicotinoid compounds and pyrethroid compound which is stable at low temperature.
  • Another object of the present invention is to provide a stable liquid agrochemical formulation of neonicotinoid compounds and pyrethroid compound capable of acting as a pesticide.
  • the present invention provides a stable liquid agrochemical formulation comprising:
  • the present invention provides a process for preparation of a stable liquid agrochemical formulation comprising at least one active ingredient in the suspended form; at least one active ingredient in partly solubilized form; at least a solubilizing medium allowing higher amount of active ingredient in the partly solubilized form; at least an aromatic hydrocarbon preventing active ingredient in the partly solubilized form from freezing at sub-zero degree celcius; and optionally one or more agrochemically acceptable excipients wherein process comprising steps of:
  • the present invention provides a use of a stable liquid agrochemical formulation as pest control solution.
  • the present invention further provides a method of controlling unwanted pests on plants or propagation material thereof, said method comprising applying an agrochemically effective amount of stable liquid agrochemical formulation comprising at least one active ingredient in the suspended form; at least one active ingredient in the partly solubilized form; at least a solubilizing medium allowing higher amount of active ingredient in the partly solubilized form; at least an aromatic hydrocarbon preventing active ingredient in the partly solubilized form from freezing at sub-zero degree celcius; and optionally one or more agrochemically acceptable excipients; to the pests or to their locus.
  • FIG. 1 Red Banded Stink Bug Adults #/25 Sweeps
  • FIG. 2 Red Banded Stink Bug Nymphs #/25 Sweeps
  • FIG. 3 Red Banded Stink Bug Adults+Nymphs #/25 Sweeps
  • a stable liquid agrochemical formulation of neonicotinoid compounds and pyrethroid compounds as the active ingredients formulated as oil dispersion formulation stable at low temperature As described herein sub-zero refers to low temperatures, especially temperatures at zero and below zero degrees celcius.
  • an oil dispersion formulation of neonicotinoid compounds and pyrethroid compounds can be obtained by stabilizing the pyrethroid compound, being at least in partly solubilized form, with a combination of solubilizing medium and an aromatic hydrocarbon.
  • a combination of solubilizing medium and aromatic hydrocarbon is found to be capable of accommodating higher amount of pyrethroid compounds in the OD formulation and impart low temperature stability to the formulation. The higher amount of pyrethroid compound is sometimes required to impart desired biological effect towards pest control.
  • the present invention provides a liquid agrochemical formulation comprising:
  • the stable liquid agrochemical formulation as claimed in claim 1 wherein, said stable liquid agrochemical formulation comprising:
  • the liquid agrochemical formulation comprises at least one active ingredient from the class of neonicotinoids such as acetamiprid, imidacloprid, clothianidin, dinotefuran, nithiazine, thiacloprid and thiamethoxam.
  • neonicotinoids such as acetamiprid, imidacloprid, clothianidin, dinotefuran, nithiazine, thiacloprid and thiamethoxam.
  • the preferred neonicotinoid is acetamiprid.
  • the neonicotinoid is imidacloprid. In an embodiment, the neonicotinoid is thiacloprid. In an embodiment, the neonicotinoid is thiamethoxam.
  • the liquid agrochemical formulation comprises from about 0.1% to about 90% of neonicotinoid of the total weight of the liquid agrochemical formulation.
  • the liquid agrochemical formulation comprises from about 1% to about 60% of neonicotinoid of the total weight of the liquid agrochemical formulation. In an embodiment, the liquid formulation comprises from about 1% to about 30% of the total weight of the neonicotinoid insecticide.
  • the liquid agrochemical formulation comprises at least one another active ingredient from the class of pyrethroids selected from the group consisting of cypermethrin, fenvalerate, permethrin, alphacypermethrin, betacypermethrin, zetacypermethrin, deltamethrin, cyfluthrin, bifenthrin, lambda-cyhalothrin, and/or bioresmethrin and mixtures thereof.
  • the pyrethroid is bifenthrin.
  • the pyrethroid is cypermethrin.
  • the liquid agrochemical formulation comprises from about 0.1% to about 90% of pyrethroids of the total weight of the liquid agrochemical formulation.
  • the liquid agrochemical formulation comprises from about 1% to about 60% of pyrethroids of the total weight of the liquid agrochemical formulation.
  • pyrethroids constitute from about 1% to about 30% of the total weight of the liquid agrochemical formulation.
  • the liquid agrochemical formulation comprises at least one solubilizing medium.
  • the solubilizing medium may be selected from the group consisting of one or more paraffins selected from octane, nonane, decane, undecane, dodecane, tridecane, tetradecane, pentadecane, hexadecane, hepta-decane, octa-decane, nona-decane, eicosane, heneicosane, docosane, tricosane, tetracosane, pentacosane, and branched chain isomers thereof; petroleum, ketones (e.g.
  • aromatic ethoxylate compounds selected from di- or tri-styrylphenol ethoxylates and their derivates, such as phosphates and sulphates and salts thereof.
  • di- or tri-styrylphenol ethoxylates or derivatives thereof include, but are not limited to, ethoxylated tristyrylphenol, sulphates and phosphates of polyarylphenol ethoxylates. These sulphates and phosphates being used either in their acid forms, or as salts, such as ammonium, triethanolamine, etc.
  • Examples of such products include: Soprophor BSU′, ‘Soprophor S25’, Soprophor TS/10, Soprophor 4D384, Soprophor 3D33, Soprophor FL, etc; vegetable oils (e.g. olive oil, kapok oil, castor oil, papaya oil, camellia oil, palm oil, sesame oil, corn oil, rice bran oil, peanut oil, cotton seed oil, soybean oil, rapeseed oil, linseed oil, tung oil, sunflower oil, safflower oil, tall oil); alkyl ester of vegetable oils (e.g.
  • C 1 -C 4 monohydric alcohol esters of C 8 to C 22 fatty acids such as methyl oleate, ethyl oleate), modified vegetable oils, methanol, ethanol, propylene glycol, isopropanol, and 1,3-propanediol, glycerine, derivatives thereof or a combination thereof.
  • the solubilizing medium may be selected from synthetically modified vegetable oils, alkyl esters of vegetable oils, modified vegetable oils and mixtures thereof.
  • the liquid agrochemical formulation comprises from about 5% to about 90% of solubilizing medium of the total weight of the liquid agrochemical formulation.
  • the liquid agrochemical formulation comprises from about 15% to about 80% of solubilizing medium of the total weight of the liquid agrochemical formulation.
  • the solubilizing medium constitutes from about 20% to about 70% of the total weight of the liquid agrochemical formulation.
  • the liquid agrochemical formulation comprises one or more aromatic hydrocarbons.
  • the aromatic hydrocarbon according to the present invention helps stabilise and avoid freezing of the partly solubilised active ingredient at low temperature.
  • the aromatic hydrocarbon imparting low temperature stability to the formulation may be selected from the group comprising of e.g. toluene, o-, m-, p-xylene, dodecane, n-decane, n-hexane, benzene, ethylbenzene, isopropylbenzene, tert-butylbenzene, naphthalenes, mono- or polyalkyl-substituted naphthalenes, heavy aromatic naphthalene (Aromatic 200, 100, 150) or mixtures thereof.
  • toluene e.g. toluene, o-, m-, p-xylene, dodecane, n-decane, n-hexane, benzene, ethylbenzene, isopropylbenzene, tert-butylbenzene, naphthalenes, mono- or polyalky
  • the liquid agrochemical formulation comprises from about 0.1% to about 60% of aromatic hydrocarbon of the total weight of the liquid agrochemical formulation.
  • the liquid agrochemical formulation comprises from about 1% to about 60% of aromatic hydrocarbon of the total weight of the liquid agrochemical formulation.
  • the liquid agrochemical formulation comprises from about 5% to about 50% of aromatic hydrocarbon of the total weight of the liquid agrochemical formulation.
  • the aromatic hydrocarbon constitutes from about 10% to about 40% of the total weight of the liquid agrochemical formulation.
  • the liquid agrochemical formulation comprises one or more rheological modifiers.
  • the rheological modifiers may be selected from hydrophobic silica, hydrophilic silica, hydrophobic fumed silica (Aerosil R 972, Cabosil TS 610, Cabosil TS 720, HDK, Aerosil R 812), hydrophilic fumed silica (Cab-O-Sil M-5), silica gels, silicates, talc, kaolin, montmorillonite, attapulgite, pumice, sepiolite, bentonite, limestone, lime, chalk, clay, dolomite, diatomaceous earth, calcite, calcium sulfate, magnesium sulfate, magnesium sulfate, magnesium oxide, sand, ammonium sulfate, ammonium phosphate, ammonium nitrate, ureas, cereal meal, tree bark meal, wood meal, nutshell meal, and cellulose powders.
  • hydrophobic silica hydrophilic silica
  • the liquid agrochemical formulation comprises from about 0.5% to about 50% of rheological modifiers of the total weight of the liquid agrochemical formulation.
  • the liquid agrochemical formulation comprises from about 1% to about 30% of rheological modifiers of the total weight of the liquid agrochemical formulation.
  • rheological modifiers constitute from about 1% to about 20% of the total weight of the liquid agrochemical formulation.
  • the liquid agrochemical formulation comprises one or more non-ionic surfactant or dispersing agents (also known as emulsifiers) and/or at least one or more anionic surfactant or dispersing agents.
  • Non-ionic surfactants or dispersing agents include all substances of this type that can normally be used in agrochemical compositions.
  • Non-ionic dispersing agents include but not limited to phosphate esters of tristyrylphenol ethoxylates (e.g., SOPROPHOR 3D33, SOPROPHOR BSU, ethoxylated triglycerides, ethoxylated aliphatic alcohols, polyalkylene oxide block copolymers of a simple primary alcohol (e.g.
  • ethylene oxide-propylene oxide block copolymers of butanol such as AtlasTM G-5000, TermulTM 5429 or TergitolTM XJ, XD or XH; polyisobutene succinic anhydride-polyethylene glycol such as AtloxTM 4914; polyoxyethylenepolyoxypropylene (EO/PO) block copolymers (e.g., PLURONIC F108, ATLOX 4912, ATLAS G-5000, SYNPERONIC PE Series copolymers) and ethylene oxidepropylene oxide based acrylic acid graft copolymers such as methyl methacrylate graft copolymers (e.g., ATLOX 4913).
  • EO/PO polyoxyethylenepolyoxypropylene
  • Anionic dispersing agents include but not limited to alkylnaphthalene sulfonates and their formaldehyde condensates (e.g., MORWET D425), polyalkylaryl sulfonates (e.g., SUPRAGIL MNS90), polymerized fatty acids (e.g., ATLOX LP-1 (12-hydroxyoctadecanoic acid homopolymer, octadecanoate), ricinoleic acid homopolymer), lignin sulfonates (e.g., ammonium lignosulfonate or sodium lignosulfonate), polyphenol sulfonates and the salts of polyacrylic acids.
  • alkylnaphthalene sulfonates and their formaldehyde condensates e.g., MORWET D425)
  • polyalkylaryl sulfonates e.g., SUPRAGIL MNS90
  • a further preferred group of anionic surfactants or dispersants includes the following salts that are of low solubility in vegetable oil: salts of polystyrenesulphonic acids, salts of polyvinylsulphonic acids, salts of naphthalenesulphonic acid-formaldehyde condensation products, salts of condensation products of naphthalenesulphonic acid, phenolsulphonic acid and formaldehyde, and salts of lignosulphonic acid.
  • emulsifiers added to the present composition include but not limited to polysaccharide ethers, polyglycosides, fatty acids, fatty alcohols, amine oxides, water-soluble cellulose derivatives, alkyl sulfonates, ethoxylated alkyl phenols, alkanaolamides, betaines, zwiterionics, carboxylated alcohols, carboxylic acids, ethoxylated alcohols, and derivatives thereof.
  • a composition provided herein further comprises emulsifiers, such as lauryl alcohol (e.g., Laureth-7), fatty acid diethanolamine (e.g., cocamide DEA), ammonium methyl sulfate and fatty alcohol ethoxylate (e.g., Steposol DG, Steposol ME), Tomadyne 100 surfactant, linear alcohol (C 12-15 ) ethoxylate, POE-7, POE-3, sodium branched dodecyl benzene sulfonate, or mixtures thereof.
  • emulsifiers such as lauryl alcohol (e.g., Laureth-7), fatty acid diethanolamine (e.g., cocamide DEA), ammonium methyl sulfate and fatty alcohol ethoxylate (e.g., Steposol DG, Steposol ME), Tomadyne 100 surfactant, linear alcohol (C 12-15 ) ethoxylate, POE-7, POE-3,
  • the liquid agrochemical formulation comprises from about 0.1% to about 40% of non-ionic surfactant or dispersing agent of the total weight of the liquid agrochemical formulation.
  • the liquid agrochemical formulation comprises from about 0.5% to about 30% of non-ionic surfactant or dispersing agent of the total weight of the liquid agrochemical formulation.
  • non-ionic surfactant or dispersing agent constitute from about 1% to about 20% of the total weight of the liquid agrochemical formulation.
  • the liquid agrochemical formulation comprises from about 0.1% to about 40% of anionic surfactant or dispersing agent of the total weight of the liquid agrochemical formulation.
  • the liquid agrochemical formulation comprises from about 0.5% to about 30% of anionic surfactant or dispersing agent of the total weight of the liquid agrochemical formulation.
  • the anionic surfactant or dispersing agent constitute from about 1% to about 20% of the total weight of the liquid agrochemical formulation.
  • the liquid agrochemical formulation comprises one or more spreading agents.
  • the spreading agents include but not limited to ethylene oxide/propylene oxide block copolymers, alcohol ethoxylates (such as Brij 010 and Brij 02), alkyl polysaccharides (such as Atplus 435 or AL2575), polyethoxylated alcohols/fatty alcohols (such as Synperonic A7, Etocas 35), alkyl phenyl ethoxylates (such as Agral 90), polyethoxylated nonyl phenyl ether carboxylic acid (such as Sandopan MA-18), tallow amine ethoxylates, oil based derivatives (either mineral or vegetable) (such as Atplus 411F and Atplus 463), sorbitol, ethoxylated Sorbitan derivatives (such as one of the Tween series of surfactants such as Tween 20, or Arlatone TV), acetylenic diol derivatives (such as one of the Surfynol series), esters of alkoxylated dieth
  • the liquid agrochemical formulation comprises from about 0.1% to about 30% of aromatic hydrocarbon of the total weight of the liquid agrochemical formulation.
  • the liquid agrochemical formulation comprises from about 0.5% to about 20% of aromatic hydrocarbon of the total weight of the liquid agrochemical formulation.
  • the aromatic hydrocarbon constitutes from about 1% to about 10% of the total weight of the liquid agrochemical formulation.
  • ingredients such as adhesives, neutralizers, thickeners, binders, sequestrates, biocides, stabilizers, buffers preservatives, antioxidants or anti-freeze agents, may also be added to the present liquid agrochemical formulation in order to increase the stability, density, and viscosity of the described formulation.
  • liquid agrochemical formulation herein may be used in conjunction with one or more other agrochemicals to control a wider variety of undesirable pests.
  • the herein described composition maybe formulated with the other agrochemicals, tank mixed with the other agrochemicals or applied sequentially with the other agrochemicals.
  • herein described composition may, optionally, be combined with or blended with other agrochemical compositions. This blend of agrochemicals may be used to control pests in crops and non-crop environments.
  • liquid agrochemical formulation herein may be used in conjunction with one or more other adjuvants.
  • the present invention may provide stable liquid agrochemical formulation comprising acetamiprid in the suspended form, bifenthrin at least in the partly solubilized form, a solubilizing medium allowing higher amount of bifenthrin in the partly solubilized form and an aromatic hydrocarbon preventing bifenthrin being in the partly solubilized form from freezing at sub-zero degree celcius.
  • a stable liquid agrochemical formulation of the present invention may comprise from about 0.1% to about 90% w/w of acetamiprid, from about 0.1% to about 90% w/w of bifenthrin, from about 5.0% to about 90% w/w of solubilizing medium allowing higher amount of bifenthrin in the partly solubilized form and from about 1.0% to about 60% w/w of an aromatic hydrocarbon preventing bifenthrin being in the partly solubilized form from freezing at sub-zero degree celcius.
  • a stable liquid agrochemical formulation of the present invention may comprise from about 1.0% to about 30% w/w of acetamiprid, from about 1.0% to about 30% w/w of bifenthrin, from about 20% to about 70% w/w of solubilizing medium and from about 10% to about 40% w/w of an aromatic hydrocarbon.
  • a stable liquid agrochemical formulation of the present invention may comprise from about 1.0% to about 30% w/w of acetamiprid, from about 1.0% to about 30% w/w of bifenthrin, from about 20% to about 70% w/w of solubilizing medium and from about 10% to about 40% w/w of an aromatic hydrocarbon as oil dispersion.
  • a stable liquid agrochemical formulation of the present invention may comprise from about 1.0% to about 30% w/w of acetamiprid, from about 1.0% to about 30% w/w of bifenthrin, from about 20% to about 70% w/w of methylated soyabean oil and from about 10% to about 40% w/w of a solvent naphtha.
  • the solvent naphtha is a heavy aromatic solvent consisting predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C12-15.
  • the present invention may provide a stable liquid agrochemical formulation comprising imidacloprid in the suspended form, cypermethrin at least in the partly solubilized form, a solubilizing medium allowing higher amount of cypermethrin in the partly solubilized form and an aromatic hydrocarbon preventing cypermethrin being in the partly solubilized form from freezing at sub-zero degree celcius.
  • a stable liquid agrochemical formulation of the present invention may comprise from about 1.0% to about 30% w/w of imidacloprid, from about 1.0% to about 30% w/w of cypermethrin, from about 20% to about 70% w/w of solubilizing medium and from about 10% to about 40% w/w of an aromatic hydrocarbon.
  • the stable liquid agrochemical formulation of the present invention is an oil dispersion.
  • the oil dispersion formulation of the invention possesses a characteristic particle size distribution.
  • the oil dispersion formulation of the invention has a particle size distribution D 10 of less than about 1.5 microns.
  • the oil dispersion formulation of the invention has a particle size distribution D 10 of less than about 1.0 microns.
  • the oil dispersion formulation of the invention has a particle size distribution D 50 of less than about 5.0 microns.
  • the oil dispersion formulation of the invention has a particle size distribution D 50 of less than about 5.0 microns.
  • the oil dispersion formulation of the invention has a particle size distribution D 50 of less than about 3.5 microns.
  • the oil dispersion formulation of the invention has a particle size distribution D 50 of less than or equal to about 3.0 microns.
  • the oil dispersion formulation of the invention has a particle size distribution D 50 of less than or equal to about 2.5 microns.
  • the oil dispersion formulation of the invention has a particle size distribution D 90 of less than or equal to about 30 microns.
  • the oil dispersion formulation of the invention has a particle size distribution D 90 of less than or equal to about 20 microns.
  • the oil dispersion formulation of the invention has a particle size distribution D 90 of less than or equal to about 10 microns.
  • the oil dispersion formulation of the invention has a particle size distribution D 100 of less than or equal to about 125 microns.
  • the oil dispersion formulation of the invention has a particle size distribution D 100 of less than or equal to about 60 microns.
  • the oil dispersion formulation of the invention has a particle size distribution D 100 of less than or equal to about 25 microns.
  • the oil dispersion formulation of the invention has a particle size distribution D 10 of less than about 1.5 microns, and D 50 of less than about 5.0 microns. In an embodiment, the oil dispersion formulation of the invention has a particle size distribution D 10 of less than about 1.0 microns, and D 50 of less than about 3.5 microns. In an embodiment, the oil dispersion formulation of the invention has a particle size distribution D 50 of less than or equal to about 3.0 microns, and D 90 of less than or equal to about 30 microns.
  • the oil dispersion formulation of the invention has a particle size distribution D 50 of less than or equal to about 2.5 microns, and D 90 of less than or equal to about 20 microns.
  • the oil dispersion formulation of the invention has a particle size distribution D 90 of less than or equal to about 10 microns, and D 100 of less than or equal to about 125 microns.
  • a process for preparation of a stable agrochemical formulation comprising at least one active ingredient in the suspended form; at least one active ingredient being at least in the partly solubilized form; at least a solubilizing medium allowing higher amount of active ingredient in the partly solubilized form; at least an aromatic hydrocarbon preventing active ingredient in the partly solubilized form from freezing at sub-zero degree celcius; and optionally one or more agrochemically acceptable excipients
  • process comprising steps of:
  • a process for the preparing a stable liquid agrochemical formulation comprises:
  • the process of the present invention comprises adding other agrochemical excipients to the mixture of step (c) before subjecting the mixture to milling.
  • the process of the present invention comprises additional conventional steps, which may be necessary but not crucial to achieve the advantages of the present invention.
  • a process for the preparing a stable liquid agrochemical formulation comprises:
  • a process for preparing the liquid agrochemical formulation comprises:
  • the present invention provides use of stable liquid agrochemical formulation comprising at least one active ingredient in the suspended form; at least one active ingredient being at least in the partly solubilized form; at least a solubilizing medium allowing higher amount of active ingredient in the partly solubilized form; at least an aromatic hydrocarbon preventing active ingredient in the partly solubilized form from freezing at sub-zero degree celcius; and optionally one or more agrochemically acceptable excipients, as a pesticide.
  • liquid agrochemical formulation according to the present invention is used as insecticide.
  • the liquid agrochemical formulation of the present invention is found to be highly active against a wide variety of chewing, boring and sucking insects, e.g. Aphids, thrips , lepidopterous larvae, sawflies, leafminers, leafhoppers, cutworms, whiteflies, soil insects, termites and some species of bitting insects, such as rice water weevil on colarado beetle etc.
  • chewing, boring and sucking insects e.g. Aphids, thrips , lepidopterous larvae, sawflies, leafminers, leafhoppers, cutworms, whiteflies, soil insects, termites and some species of bitting insects, such as rice water weevil on colarado beetle etc.
  • the liquid agrochemical formulation of the present invention is especially useful for the control of agricultural pests, or hygienic pests.
  • This formulation is highly effective for the protection of growing plants including: cotton, paddy, rice forage crops, sugarcane, cole crops, leafy vegetables, tobacco, tomatoes, potatoes, flowering ornamentals, vine crops and fruit trees from the ravages of insects.
  • a method of controlling or preventing unwanted pests on plants or propagation material thereof comprising applying an agrochemically effective amount of stable liquid agrochemical formulation according to the present invention to the pests or to their locus.
  • the present invention may provide methods of controlling or preventing unwanted pests on plants or propagation material thereof, said method comprising application of an agrochemically effective amount of a stable liquid agrochemical formulation comprising:
  • the present invention provide methods of controlling insect pest such as wide variety of chewing, boring and sucking insects, e.g. Aphids, thrips , lepidopterous larvae, sawflies, leafminers, leafhoppers, cutworms, whiteflies, soil insects, termites and some species of biting insects, such as rice water weevil on colarado beetle etc.
  • insect pest such as wide variety of chewing, boring and sucking insects, e.g. Aphids, thrips , lepidopterous larvae, sawflies, leafminers, leafhoppers, cutworms, whiteflies, soil insects, termites and some species of biting insects, such as rice water weevil on colarado beetle etc.
  • a kit comprising:
  • a methyl oleate and methyl linoleate admixture, solvent naphtha, and colloidal silicon dioxide (fumed silica) was added to a vessel and mixed until the fumed silica was in solution.
  • bifenthrin was charged. Stirring was maintained until the bifenthrin was completely solubilized.
  • the non-ionic and anionic dispersing agents were added while stirring to obtain the blend.
  • Acetamiprid was then added to the blend and stirred for at least an hour.
  • the blend thus obtained was subjected to milling under controlled conditions (temperature not to exceed beyond 20° C. during milling) to achieve the desired particle size. Once, particle size had been achieved, a complete homogeneous OD formulation was obtained.
  • the OD formulation including acetamiprid, bifenthrin and other excipients in a given ratio shown above was prepared as per the process of Example 1.
  • the OD formulation including acetamiprid, bifenthrin and other excipients in a given ratio shown above was prepared as per the process of Example 1.
  • the OD formulation including acetamiprid, bifenthrin and other excipients in a given ratio shown above was prepared as per the process of Example 1.
  • the OD formulation including acetamiprid, bifenthrin and other excipients in a given ratio shown above was prepared as per the process of Example 1.
  • the OD formulation including acetamiprid, bifenthrin and other excipients in a given ratio shown above was prepared as per the process of Example 1.
  • the OD formulation including acetamiprid, bifenthrin and other excipients in a given ratio shown above was prepared as per the process of Example 1.
  • Example 2 The viscosity of the formulations of Example 2, Example 3 and Example 4 was measured as per CIPAC MT 22.1. The measurement of dynamic viscosity is carried at room temperature. Sample to be tested for viscosity was kept undisturbed for 1 hour before measurement. The viscosity of the liquid agrochemical formulation was determined to be 350-600 cps.
  • Example 8 (With Example 9 (Without Ingredients Aromatic 200 ND) Aromatic 200 ND) Acetamiprid 11.9 11.9 Bifenthrin 18.0 18.0 Aromatic 200 ND 15.0 0.0 Silica 3.0 3.0 Tristyrylphenol 6.5 5.5 ethoxylates Methyl oleate/linoleate q.s. q.s. methyl ester Room 0° C. for 54° C. for Room 0° C. for 54° C.
  • Example-8 exhibited stability across temperature range noted by particle size growth minimization.
  • the viscosity showed a decrease at 0° C. and 54° C. but not to a significant degree.
  • 54° C. sample showed minimal bleed of ⁇ 1 cm. Water miscibility demonstrated good dispersion and only slight sedimentation that remixed easily.
  • 0° C. sample remained liquid throughout testing period.
  • Example-9 showed particle size growth across temperature range. 0° C. sample remained solidified throughout testing period. Viscosity of room temp product was low and the stability samples showed even lower viscosity. Water miscibility was fair with some sedimentation. 0° C. sample was not able to be reconstituted upon thaw.
  • the OD formulation according to the present invention was tested for storage stability.
  • the OD formulation according to the present invention was tested for stability as per CIPAC guideline at different temperature. Observations of samples for 25° C. and 0° C. after 7 days has been summarised in below:
  • Example-5 and Example-8 exhibited stability across temperature range noted by visual inspection as a cream colored suspension without any sign of sedimentation.
  • the viscosity showed decrease at 0° C. but not to a significant degree. Water miscibility demonstrated good dispersion and only slight sedimentation that remixed easily.
  • 0° C. sample remained liquid throughout testing period.
  • the OD formulation so developed was tested against marketed product named JUSTICE.
  • the technical quantities in the JUSTICE are 13% Acetamiprid and 10% Bifenthrin. It remained solidified thought out the 0° C. stability testing period.
  • Marketed product's viscosity was less than 1 across all temperature stability testing which also affect the water miscibility and dispersion.
  • Product showed no dispersion and exhibited creaming.
  • Product kept at 0° C. was not able to be reconstituted upon thaw.
  • the viscosity of OD formulation is highly critical. Even a slight increase in viscosity of the liquid phase causes active ingredients to fall out of suspension and form a layer at the bottom of the storage container. This leads to Syneresis (phase separation) and is measured as the amount of top-clearing due to phase separation.
  • Inventors of the present invention overcome syneresis problem by carefully selecting the right amount of emulsifying agents and aromatic hydrocarbon.
  • Composition of Ex-2 prepared according to the present invention remained stable during ambient and AHS study but it become solidify at zero-degree Celsius. Ex-3 and Ex-4 did not show any syneresis and remain stable as uniform dispersion throughout the study period.
  • the OD formulation prepared according to the present invention was taken for performance evaluation in controlling Redbanded Stink Bug (RBSB) pest on soybean crops.
  • RBSB Redbanded Stink Bug
  • the RBSB Piezodorus guildinii , is a Neotropical stink bug.
  • the RBSB feeds on many leguminous plants including several economically important crops such as beans, peas, alfalfa, and lentils.
  • the RBSB has become one of the most significant pests of soybean.
  • 2.52 Lb/Gal OD formulation was prepared and sprayed onto soyabean crops at two different rates, one at 5 (fl oz/a) and other at 8 (fl oz/a). The efficacy performance was tested against the untreated control i.e. soybean crops without any treatment.
  • Trial 1 of OD formulation was taken wherein 5 (fl oz/a) spray which amounts to 0.098 lb (ai/a) of OD formulation with 0.059 lb (ai/a) of bifenthrin and 0.039 lb (ai/a) of acetamiprid.
  • the OD formulation was taken wherein 8 (fl oz/a) spray which amounts to 0.158 lb (ai/a) of OD formulation with 0.095 lb (ai/a) of bifenthrin and 0.063 lb (ai/a) of acetamiprid.
  • Sweep net test was adopted as a method to estimate efficacy of OD formulation on RBSB.
  • a sweep net is a funnel-shaped net attached to a long-handled frame that is swept back and forth through the foliage. Insects captured in the net are then counted. With RBSB species, the treatment threshold for soybeans is 9 per 25 sweeps.
  • FIG. 1 shows the performance of OD formulation on Redbanded Stink Bug Adults. The observations were made on 4 th , 7 th and 14 th day after application. It was observed that OD formulation gave effective control of RBSB adults, both at 5 (fl oz/a) and 8 (fl oz/a).
  • OD formulation was sprayed on Redbanded Stink Bug Nymphs. The observations ( FIG. 2 ) were made on 4 th , 7 th and 14 th day after application. On RBSB Nymphs also OD formulation gave high control, both at 5 (fl oz/a) and 8 (fl oz/a).
  • FIG. 3 shows the observations made on combined population of RBSB Adults and RBSB Nymphs on 4th, 7th and 14th day after application.
  • the OD formulation gave high control, both at 5 (fl oz/a) and 8 (fl oz/a).

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Agronomy & Crop Science (AREA)
  • Dentistry (AREA)
  • Toxicology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Insects & Arthropods (AREA)
  • Dispersion Chemistry (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
US17/258,525 2018-07-26 2019-07-18 A stable liquid agrochemical formulation Pending US20210153503A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN201831028167 2018-07-26
IN201831028167 2018-07-26
PCT/IB2019/056149 WO2020021406A1 (en) 2018-07-26 2019-07-18 A stable liquid agrochemical formulation

Publications (1)

Publication Number Publication Date
US20210153503A1 true US20210153503A1 (en) 2021-05-27

Family

ID=69181374

Family Applications (1)

Application Number Title Priority Date Filing Date
US17/258,525 Pending US20210153503A1 (en) 2018-07-26 2019-07-18 A stable liquid agrochemical formulation

Country Status (16)

Country Link
US (1) US20210153503A1 (de)
EP (1) EP3826464A4 (de)
CN (1) CN112512317A (de)
AR (1) AR115846A1 (de)
BR (1) BR112021001409A2 (de)
CO (1) CO2021000384A2 (de)
EA (1) EA202190051A1 (de)
EC (1) ECSP21003904A (de)
MA (1) MA53392A (de)
MX (1) MX2021000736A (de)
PE (1) PE20210407A1 (de)
PH (1) PH12020552281A1 (de)
TW (1) TWI791872B (de)
UY (1) UY38317A (de)
WO (1) WO2020021406A1 (de)
ZA (1) ZA202101186B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112021025879A2 (pt) * 2020-02-12 2022-10-18 Upl Ltd Composição agroquímica
CN113749092A (zh) * 2020-06-03 2021-12-07 迈克斯(如东)化工有限公司 不饱和脂肪酸酯化物应用、农化组合物和低眼刺农药制剂及其应用
CN112028721B (zh) * 2020-07-22 2021-11-30 河南华通化工有限公司 基于高分子乳化剂的乳化炸药及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8293733B2 (en) * 2009-03-05 2012-10-23 Gat Microencapsulation Ag Oil dispersions of nAChR binding neonicotinoids
US20180125064A1 (en) * 2015-05-12 2018-05-10 Croda, Inc. Agrochemical Emulsions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005048539A1 (de) * 2005-10-11 2007-04-12 Bayer Cropscience Ag Suspensionskonzentrate auf Ölbasis
EP1886560A1 (de) * 2006-08-05 2008-02-13 Bayer CropScience AG Neue mikroemulgierbare Konzentrate
CN102113508B (zh) * 2010-01-05 2013-08-07 海南正业中农高科股份有限公司 含有联苯菊酯的杀虫杀螨组合物
EP2820952B1 (de) * 2012-02-29 2018-03-28 Sumitomo Chemical Company, Limited Suspoemulsion
EP3081086B1 (de) * 2015-04-16 2018-09-12 Rotam Agrochem International Company Limited Synergistische insektizide zusammensetzung enthaltend imidacloprid, bifenthrin und abamectin
BR102016029708B1 (pt) * 2016-12-16 2021-11-23 Iharabras S.A. Indústrias Químicas Mistura de solventes, composição compreendendo a mistura de solventes, métodos de preparação da composição de mistura de solventes, e uso da composição de mistura de solventes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8293733B2 (en) * 2009-03-05 2012-10-23 Gat Microencapsulation Ag Oil dispersions of nAChR binding neonicotinoids
US20180125064A1 (en) * 2015-05-12 2018-05-10 Croda, Inc. Agrochemical Emulsions

Also Published As

Publication number Publication date
ZA202101186B (en) 2023-10-25
TW202010407A (zh) 2020-03-16
MA53392A (fr) 2021-06-02
UY38317A (es) 2020-02-28
BR112021001409A2 (pt) 2021-04-27
CO2021000384A2 (es) 2021-01-29
PE20210407A1 (es) 2021-03-02
TWI791872B (zh) 2023-02-11
PH12020552281A1 (en) 2021-06-07
EP3826464A1 (de) 2021-06-02
CN112512317A (zh) 2021-03-16
EA202190051A1 (ru) 2021-03-15
WO2020021406A1 (en) 2020-01-30
MX2021000736A (es) 2021-03-26
AR115846A1 (es) 2021-03-03
ECSP21003904A (es) 2021-02-26
EP3826464A4 (de) 2022-04-06

Similar Documents

Publication Publication Date Title
JP5607611B2 (ja) 殺虫組成物
US20210153503A1 (en) A stable liquid agrochemical formulation
US20190150430A1 (en) Oil liquid fungicidal formulation
AU2017100047A4 (en) An aqueous suspoemulsion containing lambda-cyhalothrin and methods for making and using the same
EP3772943A1 (de) Formulierung insektizider mischungen mit propylencarbonat
WO2012040802A2 (en) Synergistic combination of abamectin and bifenthrin, process of preparation thereof and uses, and method using the same
AU2017100045A4 (en) A novel aqueous suspoemulsion and a process for preparing the same
IL276984B2 (en) Insecticides and their use
OA20007A (en) A stable liquid agrochemical formulation.
KR20230165209A (ko) 고체 미립자 해충 방제 조성물 및 방법
EP3081084B1 (de) Submikron-zusammensetzungen enthaltend imidacloprid und abamectin
EA044515B1 (ru) Стабильная жидкая агрохимическая композиция
JP2001064109A (ja) 水中油フロアブル農薬配合物
WO2020053763A1 (en) Stabilized cyclohexanedione oxime composition
US20220079144A1 (en) Emulsifier system for agricultural compositions comprising a pesticidal natural oil
WO2024013738A1 (en) Pymetrozine aqueous compositions
WO2024069656A1 (en) Insecticidal composition comprising n-(cyanomethyl)-4-(trifluoromethyl)-3-pyridinecarboxamide
CN117560993A (zh) 包含新烟碱类的液体组合物
JP2023036573A (ja) 殺虫組成物
WO2021044371A1 (en) Oil liquid fungicidal compositions

Legal Events

Date Code Title Description
STPP Information on status: patent application and granting procedure in general

Free format text: APPLICATION DISPATCHED FROM PREEXAM, NOT YET DOCKETED

STPP Information on status: patent application and granting procedure in general

Free format text: DOCKETED NEW CASE - READY FOR EXAMINATION

AS Assignment

Owner name: UPL LTD, INDIA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:JADHAV, PRAKASH MAHADEV;CANDELMO, JODY;SHROFF, JAIDEV RAJNIKANT;AND OTHERS;REEL/FRAME:059029/0980

Effective date: 20210513

STPP Information on status: patent application and granting procedure in general

Free format text: NON FINAL ACTION MAILED

STPP Information on status: patent application and granting procedure in general

Free format text: RESPONSE TO NON-FINAL OFFICE ACTION ENTERED AND FORWARDED TO EXAMINER

STPP Information on status: patent application and granting procedure in general

Free format text: NON FINAL ACTION MAILED

STPP Information on status: patent application and granting procedure in general

Free format text: RESPONSE TO NON-FINAL OFFICE ACTION ENTERED AND FORWARDED TO EXAMINER