OA20007A - A stable liquid agrochemical formulation. - Google Patents

A stable liquid agrochemical formulation. Download PDF

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Publication number
OA20007A
OA20007A OA1202100017 OA20007A OA 20007 A OA20007 A OA 20007A OA 1202100017 OA1202100017 OA 1202100017 OA 20007 A OA20007 A OA 20007A
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Prior art keywords
formulation
active ingrédient
solubilized form
liquid agrochemical
partly solubilized
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OA1202100017
Inventor
Prakash Mahadev Jadhav
Jody Candelmo
Jaidev Rajnikant Shroff
Vikram Rajnikant Shroff
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Upl Ltd
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Publication of OA20007A publication Critical patent/OA20007A/en

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Abstract

The present invention relates to a stable liquid agrochemical formulation in the form of an oil dispersion comprising neonicotinoid compounds and pyrethroid compounds that is stable at low temperatures.

Description

Field of the invention
The présent invention relates to a stable liquid agrochemical formulation. The présent invention more particularly relates to a stable liquid agrochemical formulation of more than one active ingrédients in the form of an oil dispersion.
Background of the invention
Agrochemical formulations are generally designed based on customer need and the physiochemical properties of the active ingredient(s). Liquid formulations are generally preferred over solid formulations by customers due to their ease of handling in measuring, pumping, diluting and spraying operations.
Oil dispersions (OD) are one type of liquid formulation and are defined as stable suspensions of active ingrédients in a water-immiscible fluid which may contain other dissolved active ingrédients and is intended for dilution with water before use. OD allows the formulation of active ingrédients in solid suspended form, which ingrédients cannot be formulated in water because of hydrolytic instability. Recently, OD formulations hâve been the subject of studies by companies and formulators because of their advantages with respect to the agronomie performance in the field. In addition to customer preferences for liquid formulations, oil dispersion formulations are very suitable for the following scénarios: (1) water sensitive active ingrédients, 2) compatibility issues with active ingrédient mixtures and 3) the need for build-in adjuvancy.
The basic components of an agrochemical OD formulation are the solvent or oil phase and the dispersed solid phase. These basic components may include active ingrédients, and agrochemically acceptable excipients such as petroleum or naturally derived solvents, safeners, rheology additives, emulsifiers, dispersants and other co-formulants that help deliver the desired attributes of the product.
Physico-chemical stability is the biggest concem while formulating OD. The above mentioned agrochemically acceptable excipients play a major rôle in developing stable OD formulation.
A technical challenge in the préparation of OD formulations is their préparation process per se, since the active ingrédient suspended in oil phase requires dispersing agents to stabilize the System. An indication that dispersants are not acting as expected is the large increase in viscosity of the formulation during milling leading to flocculation which is simply undesirable. In addition to the préparation problem, an OD formulation may exhibit sédimentation of the active ingrédient particles over time into a hard-packed non-redispersible layer or settling of the particles into the lower layers of the liquid column leading to the appearance of phase séparation. This phenomenon is commonly known as syneresis.
Both the above discussed problems further aggravate when OD is to be formulated using two or more active ingrédients with different physicochemical properties. Achieving stability of such OD, when one active ingrédient is présent in suspended form and the other in solubilized form becomes challenging. Stability of active ingrédients présent in suspended form may be achieved by using anti-settling agents such as thickener that increases the viscosity of the System and acts as suspending agent by reducing the settling rate of the particles. Problem exists in stabilizing active ingrédients in the solubilized form. It has been observed that stability of solubilized form may be achieved at room température, but active ingrédients become unstable as the température fluctuâtes. In such cases, sélection of solubilizing agents becomes critical to achieve physically stable OD formulation. Therefore, need exist to develop a stable OD formulation of two or more active ingrédients with different physicochemical properties.
US20160088835A1 discloses an agrochemical oil dispersion comprising an active ingrédient suspended in oil phase, dispersants, clay based rheological modifiers and emulsifying agents. The disclosed OD formulation achieved stability by incorporating dispersants and clay based rheological modifiers that prevents sédimentation of active ingrédients suspended in the oil phase. The drawback of this prior art is that clay based rheological modifiers are prone to suspensibility drop over the period of time leading to phase séparation.
Chinese Patent Application 102986718A discloses high-concentration oil-based pesticide préparation comprising acetamiprid, bifenthrin and suitable dispersant, pénétrant, thickening agent, antifreezing agent, defoaming agent and vegetable oil. The disclosed formulation offers small packing dosage with significantly improved pesticide efficacy and reduced harm to a pesticide user. The process describe in this patent is not meant for bulk manufacturing.
US2008312290 (Al) discloses an oil based suspension concentrate of sparingly soluble active substance and a moderately soluble active substance which is présent in a higher concentration than the solubility limit in the formulation. The disclosed formulation comprises a room-temperature-solid active substance from the class of neonicotinoids, a room-temperaturesolid active substance from the class of pyrethroids, pénétrant, vegetable oil, cyclohexanone, anionic and non-ionic surfactant and one or more additive selected from the group consisting of emulsifiers, foam inhibitors, preservative, antioxidants, spreaders, colorants and a thickener. The stability of such formulation in low température is unaddressed.
Although various efforts had been taken in the past to develop an OD formulation of neonicotinoids such as acetamiprid or imidacloprid and pyrethroids such as bifenthrin or cypermethrin earlier but still there is a need to provide an OD formulation of said active ingrédients which is stable at low température. Hitherto, no attempts hâve been made to solve the low température stability of OD formulation comprising neonicotinoids and pyrethroids. The low température stability becomes important for OD formulations when it is intended to be used or exposed in colder régions. Précipitation of actives or freezing of the OD formulations at low température climatic régions will lead to practical diffîculties in handling the products and will resuit in poor bio-efficacy. The stability, particularly low température stability has been of great concem when OD is exposed to various changing weather conditions. In view of the above facts, there is a need for OD formulations; in particular, formulations stable at low température, especially at sub-zero températures, while maintaining the bio-efficacy of the formulations.
Objectives of the invention
It is an object of the présent invention to provide a stable liquid agrochemical formulation of neonicotinoid compounds and pyrethroid compound which is stable at low température, especially at sub-zero température.
Another object of the présent invention is to provide a process of obtaining a stable liquid agrochemical formulation of neonicotinoid compounds and pyrethroid compound which is stable at low température.
Another object of the présent invention is to provide a stable liquid agrochemical formulation of neonicotinoid compounds and pyrethroid compound capable of acting as a pesticide.
Summary of the invention
In accordance with the above objectives, the présent invention provides a stable liquid agrochemical formulation comprising:
(a) atleast one active ingrédient in the suspended form;
(b) atleast one active ingrédient in partly solubilized form;
(c) atleast a solubilizing medium allowing a higher amount of active ingrédient in the partly solubilized form;
(d) atleast one aromatic hydrocarbon preventing the active ingrédient in the partly solubilized form from freezing at sub-zero degree Celsius; and (e) optionally one or more agrochemically acceptable excipients.
In accordance with the above objectives, the présent invention provides a process for préparation of a stable liquid agrochemical formulation comprising atleast one active ingrédient in the suspended form; atleast one active ingrédient in partly solubilized form; atleast a solubilizing medium allowing higher amount of active ingrédient in the partly solubilized form; atleast an aromatic hydrocarbon preventing active ingrédient in the partly solubilized form from freezing at sub-zero degree celcius; and optionally one or more agrochemically acceptable excipients wherein process comprising steps of:
a) adding at least one active ingrédient to be in the partly solubilized form in the mixture of solubilizing medium and aromatic hydrocarbon;
b) adding at least one active ingrédient to be in the suspended form in the mixture;
c) milling the mixture obtained in step (ii) until desired particle size is achieved.
In accordance with the above objectives, the present invention provides a use of a stable liquid agrochemical formulation as pest control solution.
In accordance with the above objectives, the present invention further provides a method of controlling unwanted pests on plants or propagation material thereof, said method comprising applying an agrochemically effective amount of stable liquid agrochemical formulation comprising atleast one active ingrédient in the suspended form; atleast one active ingrédient in the partly solubilized form; atleast a solubilizing medium allowing higher amount of active ingrédient in the partly solubilized form; atleast an aromatic hydrocarbon preventing active ingrédient in the partly solubilized form from freezing at sub-zero degree celcius; and optionally one or more agrochemically acceptable excipients; to the pests or to their locus.
Additional features and advantages of the present invention will be apparent from the detailed description that follows, which illustrâtes by way of example, the most preferred features of the present invention which are not to be construed as limiting the scope of the invention described herein.
Brief description of the drawings
Fig. 1. Red Banded Stink Bug Adults #/25 Sweeps
Fig. 2 Red Banded Stink Bug Nymphs #/25 Sweeps
Fig. 3 Red Banded Stink Bug Adults + Nymphs #/25 Sweeps
Detailed description of the invention
In accordance with the present invention, there is provided a stable liquid agrochemical formulation of neonicotinoid compounds and pyrethroid compounds as the active ingrédients formulated as oil dispersion formulation stable at low température.
As described herein sub-zero refers to low températures, especially températures at zéro and below zéro degrees celcius.
It has now been surprisingly found that an oil dispersion formulation of neonicotinoid compounds and pyrethroid compounds can be obtained by stabilizing the pyrethroid compound, being at least in partly solubilized form, with a combination of solubilizing medium and an aromatic hydrocarbon. Such a combination of solubilizing medium and aromatic hydrocarbon is found to be capable of accommodating higher amount of pyrethroid compounds in the OD formulation and impart low température stability to the formulation. The higher amount of pyrethroid compound is sometimes required to impart desired biological effect towards pest control.
In an embodiment, the présent invention provides a liquid agrochemical formulation comprising:
(a) atleast one active ingrédient in the suspended form;
(b) atleast one active ingrédient in partly solubilized form;
(c) atleast a solubilizing medium allowing a higher amount of active ingrédient in the partly solubilized form;
(d) atleast one aromatic hydrocarbon preventing the active ingrédient in the partly solubilized form from freezing at sub-zero degree celsius; and (e) optionally one or more agrochemically acceptable excipients.
The preferred features described herein below should be interpreted such that the preferences apply either independently of one another or in combination with each other. According to an embodiment ofthe présent invention, the stable liquid agrochemical formulation as claimed in claim 1 wherein, said stable liquid agrochemical formulation comprising:
(a) atleast one active ingrédient from the class of neonicotinoids in the suspended form;
(b) atleast one active ingrédient from the class of pyrethroids in the partly solubilized form;
(c) atleast a solubilizing medium allowing higher amount of active ingrédient in the partly solubilized form;
(d) atleast an aromatic hydrocarbon preventing active ingrédient in the partly solubilized form from freezing at sub-zero degree celcius; and optionally one or more agrochemically acceptable excipients.
According to another embodiment of the présent invention, the liquid agrochemical formulation comprises at least one active ingrédient from the class of neonicotinoids such as acetamiprid, imidacloprid, clothianidin, dinotefuran, nithiazine, thiacloprid and thiamethoxam.
According to another embodiment of the présent invention, the preferred neonicotinoid is acetamiprid.
In an embodiment, the neonicotinoid is imidacloprid.
In an embodiment, the neonicotinoid is thiacloprid.
In an embodiment, the neonicotinoid is thiamethoxam.
According to another embodiment of the présent invention, the liquid agrochemical formulation comprises from about 0.1% to about 90% of neonicotinoid of the total weight of the liquid agrochemical formulation.
In an embodiment, the liquid agrochemical formulation comprises from about 1% to about 60% of neonicotinoid of the total weight of the liquid agrochemical formulation.
In an embodiment, the liquid formulation comprises from about 1% to about 30% of the total weight of the neonicotinoid insecticide.
In an embodiment, the liquid agrochemical formulation comprises at least one another active ingrédient from the class of pyrethroids selected from the group consisting of cypermethrin, fenvalerate, permethrin, alphacypermethrin, betacypermethrin, zetacypermethrin, deltamethrin, cyfluthrin, bifenthrin, lambda-cyhalothrin, and/or bioresmethrin and mixtures thereof.
According to an embodiment of the présent invention, the pyrethroid is bifenthrin.
According to an embodiment, the pyrethroid is cypermethrin.
According to another embodiment of the présent invention, the liquid agrochemical formulation comprises from about 0.1% to about 90% of pyrethroids of the total weight of the liquid agrochemical formulation.
According to an embodiment, the liquid agrochemical formulation comprises from about 1% to about 60% of pyrethroids of the total weight of the liquid agrochemical formulation.
In an embodiment, pyrethroids constitute from about 1% to about 30% of the total weight of the liquid agrochemical formulation.
In an embodiment, the liquid agrochemical formulation comprises at least one solubilizing medium.
In an embodiment of the présent invention, the solubilizing medium may be selected from the group consisting of one or more paraffins selected from octane, nonane, decane, undecane, dodecane, tridecane, tetradecane, pentadecane, hexadecane, hepta-decane, octa-decane, nonadecane, eicosane, heneicosane, docosane, tricosane, tetracosane, pentacosane, and branched chain isomers thereof; petroleum, ketones (e.g. acetophenone, cyclohexanone); aromatic ethoxylate compounds selected from di- or tri-styrylphenol ethoxylates and their dérivâtes, such as phosphates and sulphates and salts thereof. Examples of the one or more di- or tri-styrylphenol ethoxylates or dérivatives thereof include, but are not limited to, ethoxylated tristyrylphenol, sulphates and phosphates of polyarylphenol ethoxylates. These sulphates and phosphates being used either in their acid forms, or as salts, such as ammonium, triethanolamine, etc. Examples of such products include: Soprophor BSU', 'Soprophor S25', Soprophor TS/10, Soprophor 4D384, Soprophor 3D33, Soprophor FL, etc; vegetable oils (e.g. olive oil, kapok oil, castor oil, papaya oil, camellia oil, palm oil, sesame oil, com oil, rice bran oil, peanut oil, cotton seed oil, soybean oil, rapeseed oil, linseed oil, tung oil, sunflower oil, safflower oil, tall oil); alkyl ester of vegetable oils (e.g. rapeseed oil methyl ester or rapeseed oil ethyl ester, rapeseed oil propyl esters, rapeseed oil butyl esters, tall oil fatty acids esters etc.); diesel, minerai oil, fatty acid amides (e.g. C1-C3 amines, alkylamines or alkanolamines with Ce-Cis carboxylic acids), fatty acids, alkyl esters of fatty acids (e.g. C1-C4 monohydric alcohol esters of Cs to C22 fatty acids such as methyl oleate, ethyl oleate), modified vegetable oils, methanol, éthanol, propylene glycol, isopropanol, and 1 ,3-propanedioI, glycérine, dérivatives thereof or a combination thereof.
In an embodiment, the solubilizing medium may be selected from synthetically modified vegetable oils, alkyl esters of vegetable oils, modified vegetable oils and mixtures thereof.
In an embodiment, the liquid agrochemical formulation comprises from about 5% to about 90% of solubilizing medium of the total weight of the liquid agrochemical formulation.
In an embodiment, the liquid agrochemical formulation comprises from about 15% to about 80% of solubilizing medium of the total weight of the liquid agrochemical formulation.
In an embodiment, the solubilizing medium constitutes from about 20% to about 70% of the total weight of the liquid agrochemical formulation.
In an embodiment, the liquid agrochemical formulation comprises one or more aromatic hydrocarbons.
In an embodiment, the aromatic hydrocarbon according to the présent invention helps stabilise and avoid freezing of the partly solubilised active ingrédient at low température.
In an embodiment, the aromatic hydrocarbon imparting low température stability to the formulation may be selected from the group comprising of e.g. toluene, o-, m-, p-xylene, dodecane, n-decane, n-hexane, benzene, ethylbenzene, isopropylbenzene, tert-butylbenzene, naphthalenes, mono- or polyalkyl-substituted naphthalenes, heavy aromatic naphthalene (Aromatic 200, 100, 150) or mixtures thereof.
In an embodiment, the liquid agrochemical formulation comprises from about 0.1% to about 60% of aromatic hydrocarbon of the total weight of the liquid agrochemical formulation.
In an embodiment, the liquid agrochemical formulation comprises from about 1% to about 60% of aromatic hydrocarbon ofthe total weight ofthe liquid agrochemical formulation.
In an embodiment, the liquid agrochemical formulation comprises from about 5% to about 50% of aromatic hydrocarbon of the total weight of the liquid agrochemical formulation.
In an embodiment of the présent invention, the aromatic hydrocarbon constitutes from about 10% to about 40% of the total weight of the liquid agrochemical formulation.
In an embodiment, the liquid agrochemical formulation comprises one or more rheological modifiers.
In an embodiment, the rheological modifiers may be selected from hydrophobie silica, hydrophilic silica, hydrophobie fumed silica (Aerosil R 972, Cabosil TS 610, Cabosil TS 720,
HDK, Aerosil R 812), hydrophilic fumed silica (Cab-O-Sil M-5), silica gels, silicates, talc, kaolin, montmorillonite, attapulgite, pumice, sepiolite, bentonite, limestone, lime, chalk, clay, dolomite, diatomaceous earth, calcite, calcium sulfate, magnésium sulfate, magnésium sulfate, magnésium oxide, sand, ammonium sulfate, ammonium phosphate, ammonium nitrate, ureas, cereal meal, tree bark meal, wood meal, nutshell meal, and cellulose powders.
In an embodiment, the liquid agrochemical formulation comprises from about 0.5% to about 50% of rheological modifiers of the total weight of the liquid agrochemical formulation.
In an embodiment, the liquid agrochemical formulation comprises from about 1% to about 30% of rheological modifiers of the total weight of the liquid agrochemical formulation.
In an embodiment, rheological modifiers constitute from about 1% to about 20% of the total weight of the liquid agrochemical formulation.
In an embodiment, the liquid agrochemical formulation comprises one or more non-ionic surfactant or dispersing agents (also known as emulsifîers) and/or at least one or more anionic surfactant or dispersing agents.
Suitable non-ionic surfactants or dispersing agents include ail substances of this type that can normally be used in agrochemical compositions. Non-ionic dispersing agents include but not limited to phosphate esters of tristyrylphenol ethoxylates (e.g., SOPROPHOR 3D33, SOPROPHOR BSU, ethoxylated triglycérides, ethoxylated aliphatic alcohols, polyalkylene oxide block copolymers of a simple primary alcohol (e.g. ethylene oxide-propylene oxide block copolymers of butanol) such as Atlas™ G-5000, Termul™ 5429 or Tergitol™ XJ, XD or XH; polyisobutene succinic anhydride-poly ethylene gly col such as Atlox™ 4914; polyoxyethylenepolyoxypropylene (EO/PO) block copolymers (e.g., PLURONIC F108, ATLOX 4912, ATLAS G-5000, SYNPERONIC PE Sériés copolymers) and ethylene oxidepropylene oxide based acrylic acid graft copolymers such as methyl méthacrylate graft copolymers (e.g., ATLOX 4913).
Anionic dispersing agents include but not limited to alkylnaphthalene sulfonates and their formaldéhyde condensâtes (e.g., MORWET D425), polyalkylan l sulfonates (e.g., SUPRAGIL MNS90), polymerized fatty acids (e.g., ATLOX LP-1 (12-hydroxyoctadecanoic acid homopolymer, octadecanoate), ricinoleic acid homopolymer), lignin sulfonates (e.g., ammonium lignosulfonate or sodium lignosulfonate), polyphenol sulfonates and the salts of polyacrylic acids. A further preferred group of anionic surfactants or dispersants includes the following salts that are of low solubility in vegetable oil: salts of polystyrenesulphonic acids, salts of polyvinylsulphonic acids, salts of naphthalenesulphonic acid-formaldehyde condensation products, salts of condensation products of naphthalenesulphonic acid, phenolsulphonic acid and formaldéhyde, and salts of lignosulphonic acid.
Other emulsifiers added to the présent composition include but not limited to polysaccharide ethers, polyglycosides, fatty acids, fatty alcohols, amine oxides, water-soluble cellulose dérivatives, alkyl sulfonates, ethoxylated alkyl phénols, alkanaolamides, betaines, zwiterionics, carboxylated alcohols, carboxylic acids, ethoxylated alcohols, and dérivatives thereof. In certain embodiments, a composition provided herein further comprises emulsifiers, such as lauryl alcohol (e.g., Laureth-7), fatty acid diethanolamine (e.g., cocamide DEA), ammonium methyl sulfate and fatty alcohol ethoxylate (e.g., Steposol DG, Steposol ME), Tomadyne 100 surfactant, linear alcohol (C12-15) ethoxylate, POE-7, POE-3, sodium branched dodecyl benzene sulfonate, or mixtures thereof.
In an embodiment, the liquid agrochemical formulation comprises from about 0.1% to about 40% of non-ionic surfactant or dispersing agent of the total weight of the liquid agrochemical formulation.
In an embodiment, the liquid agrochemical formulation comprises from about 0.5% to about 30% of non-ionic surfactant or dispersing agent of the total weight of the liquid agrochemical formulation.
In an embodiment, non-ionic surfactant or dispersing agent constitute from about 1% to about 20% of the total weight of the liquid agrochemical formulation.
In an embodiment, the liquid agrochemical formulation comprises from about 0.1% to about 40% of anionic surfactant or dispersing agent of the total weight of the liquid agrochemical formulation.
In an embodiment, the liquid agrochemical formulation comprises from about 0.5% to about 30% of anionic surfactant or dispersing agent ofthe total weight ofthe liquid agrochemical formulation.
In an embodiment, the anionic surfactant or dispersing agent constitute from about 1% to about 20% ofthe total weight ofthe liquid agrochemical formulation.
In an embodiment, the liquid agrochemical formulation comprises one or more spreading agents.
In an embodiment, the spreading agents include but not limited to ethylene oxide/propylene oxide block copolymers, alcohol ethoxylates (such as Brij 010 and Brij 02), alkyl polysaccharides (such as Atplus 435 or AL2575), polyethoxylated alcohols/fatty alcohols (such as Synperonic A7, Etocas 35), alkyl phenyl ethoxylates (such as Agral 90), polyethoxylated nonyl phenyl ether carboxylic acid (such as Sandopan MA-18), tallow amine ethoxylates, oil based dérivatives (either minerai or vegetable) (such as Atplus 411F and Atplus 463), sorbitol, ethoxylated Sorbitan dérivatives (such as one of the Tween sériés of surfactants such as Tween 20, or Arlatone TV), acetylenic diol dérivatives (such as one of the Surfynol sériés), esters of alkoxylated diethylethanolamine (such as Atlox 4915), and polyethyleneglycoL
In an embodiment, the liquid agrochemical formulation comprises from about 0.1% to about 30% of aromatic hydrocarbon of the total weight of the liquid agrochemical formulation.
In an embodiment, the liquid agrochemical formulation comprises from about 0.5% to about 20% of aromatic hydrocarbon of the total weight of the liquid agrochemical formulation.
In an embodiment, the aromatic hydrocarbon constitutes from about 1% to about 10% of the total weight of the liquid agrochemical formulation.
Other ingrédients, such as adhesives, neutralizers, thickeners, binders, séquestrâtes, 10 biocides, stabilizers, buffers preservatives, antioxidants or anti-freeze agents, may also be added to the présent liquid agrochemical formulation in order to increase the stability, density, and viscosity of the described formulation.
Further, the liquid agrochemical formulation herein may be used in conjunction with one 15 or more other agrochemicals to control a wider variety of undesirable pests. When used in conjunction with other agrochemicals, the herein described composition maybe formulated with the other agrochemicals, tank mixed with the other agrochemicals or applied sequentially with the other agrochemicals. In addition, herein described composition may, optionally, be combined with or blended with other agrochemical compositions. This blend of agrochemicals may be used to 20 control pests in crops and non-crop environments.
In some embodiments, the liquid agrochemical formulation herein may be used in conjunction with one or more other adjuvants.
According to an embodiment, the présent invention may provide stable liquid agrochemical formulation comprising acetamiprid in the suspended form, bifenthrin atleast in the 25 partly solubilized form, a solubilizing medium allowing higher amount of bifenthrin in the partly solubilized form and an aromatic hydrocarbon preventing bifenthrin being in the partly solubilized form from freezing at sub-zero degree celcius.
According to an embodiment, a stable liquid agrochemical formulation of the présent invention may comprise from about 0.1% to about 90% w/w of acetamiprid, from about 0.1% to 30 about 90% w/w of bifenthrin, from about 5.0% to about 90% w/w of solubilizing medium allowing higher amount of bifenthrin in the partly solubilized form and from about 1.0% to about 60% w/w of an aromatic hydrocarbon preventing bifenthrin being in the partly solubilized form from freezing at sub-zero degree celcius.
According to an embodiment, a stable liquid agrochemical formulation of the présent 35 invention may comprise from about 1.0 % to about 30% w/w of acetamiprid, from about 1.0% to about 30% w/w of bifenthrin, from about 20% to about 70% w/w of solubilizing medium and from about 10% to about 40% w/w of an aromatic hydrocarbon.
According to an embodiment, a stable liquid agrochemical formulation of the présent invention may comprise from about 1.0 % to about 30% w/w of acetamiprid, from about 1.0% to about 30% w/w of bifenthrin, from about 20% to about 70% w/w of solubilizing medium and from about 10% to about 40% w/w of an aromatic hydrocarbon as oil dispersion.
According to an embodiment, a stable liquid agrochemical formulation of the présent invention may comprise from about 1.0 % to about 30% w/w of acetamiprid, from about 1.0% to about 30% w/w of bifenthrin, from about 20% to about 70% w/w of methylated soyabean oil and from about 10% to about 40% w/w of a solvent naphtha.
In an embodiment, the solvent naphtha is a heavy aromatic solvent consisting predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C12-15.
In an embodiment, the présent invention may provide a stable liquid agrochemical formulation comprising imidacloprid in the suspended form, cypermethrin atleast in the partly solubilized form, a solubilizing medium allowing higher amount of cypermethrin in the partly solubilized form and an aromatic hydrocarbon preventing cypermethrin being in the partly solubilized form from freezing at sub-zero degree celcius.
According to an embodiment, a stable liquid agrochemical formulation of the présent invention may comprise from about 1.0 % to about 30% w/w of imidacloprid, from about 1.0% to about 30% w/w of cypermethrin, from about 20% to about 70% w/w of solubilizing medium and from about 10% to about 40% w/w of an aromatic hydrocarbon.
In an embodiment, the stable liquid agrochemical formulation of the présent invention is an oil dispersion.
In an embodiment, the oil dispersion formulation of the invention possesses a characteristic particle size distribution.
In an embodiment, the oil dispersion formulation of the invention has a particle size distribution Dio of less than about 1.5 microns.
In an embodiment, the oil dispersion formulation of the invention has a particle size distribution Dw of less than about 1.0 microns.
In an embodiment, the oil dispersion formulation of the invention has a particle size distribution D50 of less than about 5.0 microns.
In an embodiment, the oil dispersion formulation of the invention has a particle size distribution Dso of less than about 5.0 microns.
In an embodiment, the oil dispersion formulation of the distribution D50 of less than about 3.5 microns.
In an embodiment, the oil dispersion formulation of the distribution D50 of less than or equal to about 3.0 microns.
In an embodiment, the oil dispersion formulation of the distribution D50 of less than or equal to about 2.5 microns.
In an embodiment, the oil dispersion formulation of the distribution D90 of less than or equal to about 30 microns.
In an embodiment, the oil dispersion formulation of the distribution D90 of less than or equal to about 20 microns.
In an embodiment, the oil dispersion formulation of the distribution D90 of less than or equal to about 10 microns.
In an embodiment, the oil dispersion formulation of the distribution Dwo of less than or equal to about 125 microns.
In an embodiment, the oil dispersion formulation of the distribution D100 of less than or equal to about 60 microns.
In an embodiment, the oil dispersion formulation of the distribution D100 of less than or equal to about 25 microns.
In an embodiment, the oil dispersion formulation of the invention has a particle size invention has a particle size invention has a particle size invention has a particle size invention has a particle size invention has a particle size invention has a particle size invention has a particle size invention has a particle size invention has a particle size distribution D10 of less than about 1.5 microns, and D50 of less than about 5.0 microns.
In an embodiment, the oil dispersion formulation of the invention has a particle size distribution D10 of less than about 1.0 microns, and D50 of less than about 3.5 microns.
In an embodiment, the oil dispersion formulation of the invention has a particle size distribution D50 of less than or equal to about 3.0 microns, and D90 of less than or equal to about 30 microns.
In an embodiment, the oil dispersion formulation of the invention has a particle size distribution D50 of less than or equal to about 2.5 microns, and D90 of less than or equal to about 20 microns.
In an embodiment, the oil dispersion formulation of the invention has a particle size distribution D90 of less than or equal to about 10 microns, and Dwo of less than or equal to about 125 microns.
According to an embodiment of the présent invention, a process for préparation of a stable agrochemical formulation comprising atleast one active ingrédient in the suspended form; atleast one active ingrédient being at least in the partly solubilized form; atleast a solubilizing medium allowing higher amount of active ingrédient in the partly solubilized form; atleast an aromatic hydrocarbon preventing active ingrédient in the partly solubilized form from freezing at sub-zero degree celcius; and optionally one or more agrochemically acceptable excipients wherein process comprising steps of:
a) adding at least one active ingrédient to be in the partly solubilized form in the mixture of solubilizing medium and aromatic hydrocarbon.
b) adding at least one active ingrédient to be in the suspended form in the mixture;
c) milling the mixture obtained in step (ii) until desired particle size is achieved.
According to an embodiment of the présent invention, a process for the preparing a stable liquid agrochemical formulation comprises:
(a) solubilizing at least one active ingrédient in a mixture of solubilizing medium and aromatic hydrocarbon;
(b) adding at least one dispersing agent;
(c) adding at least another active ingrédient to be in the suspended form ; and (d) milling the mixture obtained in step (c) until desired particle size is achieved.
In an embodiment, the process of the présent invention comprises adding other agrochemical excipients to the mixture of step (c) before subjecting the mixture to milling.
In an embodiment, the process of the présent invention comprises additional conventional steps, which may be necessary but not crucial to achieve the advantages of the présent invention.
According to an embodiment of the présent invention, a process for the preparing a stable liquid agrochemical formulation comprises:
1) solubilizing at least one solid low melting pyrethroid compound in the mixture of solubilizing medium and aromatic hydrocarbon;
2) adding dispersing agents;
3) adding at least one neonicotinoid compound to be in the suspended form and mix it well;
4) optionally adding other agrochemical excipients necessary to impart stability to the liquid agrochemical formulation;
5) milling the mixture obtained in step (3) until desired particle size is achieved.
According to an embodiment of the présent invention, a process for preparing the liquid agrochemical formulation comprises:
1) solubilizing bifenthrin in the mixture of solubilizing medium and aromatic hydrocarbon;
2) adding dispersing agents;
3) adding acetamiprid to be in the suspended form and mix it well;
4) optionally adding other agrochemical excipients necessary to impart stability to the liquid agrochemical formulation;
5) milling the mixture obtained in step (3) until desired particle size is achieved.
According to an embodiment, the present invention provides use of stable liquid agrochemical formulation comprising atleast one active ingrédient in the suspended form; atleast one active ingrédient being at least in the partly solubilized form; atleast a solubilizing medium allowing higher amount of active ingrédient in the partly solubilized form; atleast an aromatic hydrocarbon preventing active ingrédient in the partly solubilized form from freezing at sub-zero degree celcius; and optionally one or more agrochemically acceptable excipients, as a pesticide.
In an embodiment, the liquid agrochemical formulation according to the present invention is used as insecticide.
According to another embodiment, the liquid agrochemical formulation of the present invention is found to be highly active against a wide variety of chewing, boring and sucking insects, e.g. Aphids, thrips, lepidopterous larvae, sawflies, leafminers, leafhoppers, cutworms, whiteflies, soil insects, termites and some species of bitting insects, such as rice water weevil on colarado beetel etc.
According to another embodiment, the liquid agrochemical formulation of the present invention is especially useful for the control of agricultural pests, or hygienic pests. This formulation is highly effective for the protection of growing plants including: cotton, paddy, rice forage crops, sugarcane, cole crops, leafy vegetables, tobacco, tomatoes, potatoes, flowering ornamentals, vine crops and fruit trees from the ravages of insects.
According to another embodiment of the present invention, a method of controlling or preventing unwanted pests on plants or propagation material thereof is provided, said method comprising applying an agrochemically effective amount of stable liquid agrochemical formulation according to the present invention to the pests or to their locus.
Thus, in an embodiment, the present invention may provide methods of controlling or preventing unwanted pests on plants or propagation material thereof, said method comprising application of an agrochemically effective amount of a stable liquid agrochemical formulation comprising:
a) atleast one active ingrédient in the suspended form;
b) atleast one active ingrédient in the partly solubilized form;
c) atleast a solubilizing medium allowing higher amount of active ingrédient in the partly solubilized form;
d) atleast an aromatic hydrocarbon preventing active ingrédient in the partly solubilized form from freezing at sub-zero degree celcius;
and optionally one or more agrochemically acceptable excipients.
In an embodiment, the present invention provide methods of controlling insect pest such as wide variety of chewing, boring and sucking insects, e.g. Aphids, thrips, lepidopterous larvae, sawflies, leafminers, leafhoppers, cutworms, whiteflies, soil insects, termites and some species of biting insects, such as rice water weevil on colarado beetel etc.
In an embodiment of the présent invention, a kit is provided, said kit comprising:
a) atleast one active ingrédient in the suspended form;
b) atleast one active ingrédient in the partly solubilized form;
c) atleast a solubilizing medium allowing higher amount of active ingrédient in the partly solubilized form;
d) atleast an aromatic hydrocarbon preventing active ingrédient in the partly solubilized form from freezing at sub-zero degree celcius;
and optionally one or more agrochemically acceptable excipients;
wherein said kit is used as a pesticide.
EXAMPLE 1
A stable liquid agrochemical formulation was made according to following procedure:
A methyl oleate and methyl linoleate admixture, solvent naphtha, and colloïdal Silicon dioxide (fumed silica) was added to a vessel and mixed until the fumed silica was in solution. Under stirring, bifenthrin was charged. Stirring was maintained until the bifenthrin was completely solubilized. The non-ionic and anionic dispersing agents were added while stirring to obtain the blend. Acetamiprid was then added to the blend and stirred for atleast an hour. The blend thus obtained was subjected to milling under controlled conditions (température not to exceed beyond 20°C during milling) to achieve the desired particle size. Once, particle size had been achieved, a complété homogeneous OD formulation was obtained.
Ingrédients Quantity (%)
Acetamiprid 11.88
Bifenthrin 18.33
Solvent naphtha 15
Colloïdal Silicon dioxide 3
Ethylene oxide-propylene oxide block copolymers 1-15
Methyl oleate/linoleate methyl ester q.s.
100.00
EXAMPLE 2
Ingrédients Quantity (%)
Acetamiprid 11.9
Bifenthrin 18
Aromatic 200 ND 10
Fumed silica 3
Polyisobutene succinic anhydride-polyethylene glycol 1-15
Rapeseed oil methyl ester q.s.
100.00
The OD formulation including acetamiprid, bifenthrin and other excipients in a given ratio shown above was prepared as per the process of Example 1.
EXAMPLE 3
Ingrédients Quantity (%)
Acetamiprid 11.9
Bifenthrin 18
Aromatic 150 ND 20
Fumed silica 3
Polyoxyethylenepolyoxypropylene (EO/PO) block copolymers 1-15
Sodium branched dodecyl benzene sulfonate q.s.
100.00
The OD formulation including acetamiprid, bifenthrin and other excipients in a given ratio shown above was prepared as per the process of Example 1.
EXAMPLE 4
Ingrédients Quantity (%)
Acetamiprid 11.9
Bifenthrin 18
Aromatic 200 ND 20
Bentonite 2
Alkylnaphthalene sulfonates 1-15
Soyabean oil methyl ester q.s.
100.00____________
The OD formulation including acetamiprid, bifenthrin and other excipients in a given ratio shown above was prepared as per the process of Example 1.
EXAMPLE 5
Ingrédients Quantity (%)
Acetamiprid 11.9
Bifenthrin 18.36
Aromatic 150 ND 15
Fumed silica 3
Ethylene oxide-propylene oxide block copolymers 1-15
Methyl oleate/linoleate methyl ester q.s.
100.00
The OD formulation including acetamiprid, bifenthrin and other excipients in a given ratio shown above was prepared as per the process of Example 1.
EXAMPLE 6
Ingrédients Quantity (%)
Acetamiprid 15.1
Bifenthrin 15.1
Aromatic 200 ND 15
Fumed silica 3
Tristyrylphenol ethoxylates 1-15
Cyclohexanone q.s.
100.00
The OD formulation including acetamiprid, bifenthrin and other excipients in a given ratio shown above was prepared as per the process of Example 1.
EXAMPLE 7
Ingrédients Quantity (%)
Acetamiprid 18.0
Bifenthrin 12.0
Aromatic 150 ND 15.0
Bentonite 3.0
Ethylene oxide-propylene oxide block copolymers 1-15
Methyl oleate/linoleate methyl ester q.s.
100.00
The OD formulation including acetamiprid, bifenthrin and other excipients in a given ratio shown above was prepared as per the process of Example 1.
Détermination of Viscosity
The viscosity of the formulations of Example 2, Example 3 and Example 4 was measured as per CIPAC MT 22.1. The measurement of dynamic viscosity is carried at room température. Sample to be tested for viscosity was kept undisturbed for 1 hour before measurement. The viscosity of the liquid agrochemical formulation was determined to be 350 - 600 cps.
Examples Viscosity
Example 2 432
Example 3 568
Example 4 506
Study of effect of the presence of aromatic hydrocarbon in the OD formulation:
To observe the effect of aromatic hydrocarbon in the stabilization of OD formulation developed according to the présent invention, a comparative study was performed wherein 5 EXAMPLE-8 was developed with aromatic 200 ND (solvent naphtha) inclusion and EXAMPLE-9 was developed wherein ail the ingrédients similar to Example-8 were présent excluding aromatic 200 ND. Table-1 shows the stability of these formulations over température range.
Table-1
Ingrédients Example 8 (With Aromatic 200 ND) Example 9 (Without Aromatic 200 ND)
Acetamiprid 11.9 11.9
Bifenthrin 18.0 18.0
Aromatic 200 ND 15.0 0.0
Silica 3.0 3.0
Tristyrylphenol ethoxylates 6.5 5.5
Methyl oleate/linoleate methyl ester q.s. q.s.
Room Temp 0 °C for 1 Week 54 °C for 2 Weeks Room Temp 0°C for 1 Week 54 °C for 2 Weeks
dlO pm 0.878 0.813 0.723 0.615 1.318 0.62
d50 μιη 2.266 3.109 3.529 4.336 25.76 3.344
d90 μm 8.193 7.983 10.59 17.8 81.57 26.19
dlOO μm 22.73 111 52.63 52.63 194.2 111
Viscosity 375 364 238 314 0 168
Bleeding No No <1 cm No No 0.5 cm
Visual Observation Cream Color Suspension Cream Color Suspension Cream Color Suspension Cream Color Suspension Solid Cream Color Suspension
Conclusion: As observed from the Table-1, Example-8 exhibited stability across température range noted by particle size growth minimization. The viscosity showed a decrease at 0°C and 54°C but not to a significant degree. 54°C sample showed minimal bleed of <1 cm. Water miscibility demonstrated good dispersion and only slight sédimentation that remixed easily. 0°C sample remained liquid throughout testing period.
As observed from the Table-1, Example-9 showed particle size growth across température range. 0°C sample remained solidified throughout testing period. Viscosity of room temp product was low and the stability samples showed even lower viscosity. Water miscibility was fair with some sédimentation. 0°C sample was not able to be reconstituted upon thaw.
Test for Low Température Stability
The OD formulation according to the présent invention was tested for storage stability. The OD formulation according to the présent invention was tested for stability as per CIP AC guideline at different température. Observations of samples for 25°C and 0°C after 7 days has been summarised in below:
Table-2
Formulation Example no. Appearance at 25°C after 7 days Appearance at 0°C after 7 days
Example 5 Cream Color Suspension Cream Color Suspension
Example 8 Cream Color Suspension Cream Color Suspension
Justice OD, commercial sample Cream Color Suspension Solidified
Conclusion: As observed from the Table-2, Example-5 and Example-8 exhibited stability across température range noted by visual inspection as a cream colored suspension without any sign of sédimentation. The viscosity showed decrease at 0°C but not to a significant degree. Water 15 miscibility demonstrated good dispersion and only slight sédimentation that remixed easily. 0°C sample remained liquid throughout testing period.
The OD formulation so developed was tested against marketed product named JUSTICE. The technical quantities in the JUSTICE are 13% Acetamiprid and 10% Bifenthrin. It remained solidified thought out the 0°C stability testing period. Marketed product’s viscosity was less than 1 20 across ail température stability testing which also affect the water miscibility and dispersion.
Product showed no dispersion and exhibited creaming. Product kept at 0°C was not able to be reconstituted upon thaw.
Test for Storage Stability:
The OD stability of the formulations according to the présent invention was tested after 24 hrs of dilution and the results are summarised below:
Table -3
Ingrédients Exm-2 Exm-3 Exm-4
Viscosity 432 568 506
Density 1.01 1.03 1.01
Wet sieve (100 mesh) 0.01 0.01 0.01
Wet sieve (325 mesh) 0.1 0.15 0.02
Lumisizer séparation index 0.708 0.290 1.02
Stability RT 1 Day Uniform Dispersion Uniform Dispersion Uniform Dispersion
Stability 54°C 14 Days Uniform Dispersion Uniform Dispersion Uniform Dispersion
Observations related to syneresis Solidification at 0°C Less than 1ml Less than 1ml
The viscosity of OD formulation is highly critical. Even a slight increase in viscosity of the liquid phase causes active ingrédients to fall out of suspension and form a layer at the bottom of the storage container. This leads to Syneresis (phase séparation) and is measured as the amount of top-clearing due to phase séparation. Inventors of the présent invention overcome syneresis problem by carefully selecting the right amount of emulsifying agents and aromatic hydrocarbon. Composition of Ex-2 prepared according to the présent invention remained stable during ambient and AHS study but it become solidify at zero-degree Celsius. Ex-3 and Ex-4 did not show any syneresis and remain stable as uniform dispersion throughout the study period.
Biological Efficacy of OD Formulation
Crop Selected (pest infested): Soybean
Targeted Pests: Red Banded Stink Bug
Objective of trial: To evaluate the performance of OD Formulation.
Treatments: 2.52 Lb/Gal
Spray Volume: 5 fl oz/a and 8 fl oz/a
Method adopted: Sweep Net Test
Table-4
No. Name Concentration (LB/GAL) Type Rate 1b (ai/a) Rate (fl oz/a)
1 Untreated Check
Trial 1
2 Formulation as per Example1 2.52 SC 0.098 5
Bifenthrin 1.52 0.059
Acetamiprid 1 0.039
Trial 2
3 Formulation as per Example1 2.52 SC 0.158 8
Bifenthrin 1.52 0.095
Acetamiprid 1 0.063
The OD formulation prepared according to the présent invention was taken for performance évaluation in controlling Redbanded Stink Bug (RBSB) pest on soybean crops. The RBSB, Piezodorus guildinii, is a Neotropical stink bug. The RBSB feeds on many leguminous plants including several economically important crops such as beans, peas, alfalfa, and lentils. The RBSB has become one of the most significant pests of soybean.
2.52 Lb/Gal OD formulation was prepared and sprayed onto soyabean crops at two different rates, one at 5 (fl oz/a) and other at 8 (fl oz/a). The efficacy performance was tested against the untreated control i.e. soybean crops without any treatment. Trial 1 of OD formulation was taken wherein 5 (fl oz/a) spray which amounts to 0.098 1b (ai/a) of OD formulation with 0.059 1b (ai/a) of bifenthrin and 0.039 1b (ai/a) of acetamiprid. Similarly, in Trial 2, the OD formulation was taken wherein 8 (fl oz/a) spray which amounts to 0.158 1b (ai/a) of OD formulation with 0.095 1b (ai/a) of bifenthrin and 0.063 1b (ai/a) of acetamiprid.
Sweep net test was adopted as a method to estimate efficacy of OD formulation on RBSB. A sweep net is a funnel-shaped net attached to a long-handled frame that is swept back and forth through the foliage. Insects captured in the net are then counted. With RBSB species, the treatment threshold for soybeans is 9 per 25 sweeps.
Fig. 1 shows the performance of OD formulation on Redbanded Stink Bug Adults. The observations were made on 4% 7* and 14ül day after application. It was observed that OD formulation gave effective control of RBSB adults, both at 5 (fl oz/a) and 8 (fl oz/a).
Similarly, OD formulation was sprayed on Redbanded Stink Bug Nymphs. The observations (Fig. 2) were made on 4*, 7th and 14th day after application. On RBSB Nymphs also OD formulation gave high control, both at 5 (fl oz/a) and 8 (fl oz/a).
Fig. 3 shows the observations made on combined population of RBSB Adults and RBSB Nymphs on 4*, 7th and 14Λ day after application. On the combined population of RBSB adults and Nymphs, the OD formulation gave high control, both at 5 (fl oz/a) and 8 (fl oz/a).
It was concluded that ail treatments planned in various concentration rates with the OD 5 formulation developed according to the présent invention found to be effective. OD formulation at 8 (fl oz/a) showed the best control of RBSB nymphs on 4DAA (4 day after application). At 7DAA, ail treatments had lower RBSB populations (adult and nymph) than the untreated check. And at 14 DAA, ail treatments had fewer nymphs than the untreated check. This concludes that the OD formulation developed according to the présent invention found to be very effective in controlling 10 RBSB population on soybean crop.

Claims (17)

1. A stable liquid agrochemical formulation comprising:
(a) at least one active ingrédient in the suspended form;
(b) at least one active ingrédient in the partly solubilized form;
(c) at least a solubilizing medium allowing higher amount of active ingrédient in the partly solubilized form;
(d) at least one aromatic hydrocarbon preventing active ingrédient in the partly solubilized form from freezing at sub-zero degree celcius; and
2. The stable liquid agrochemical formulation as claimed in claim 1 wherein, said stable liquid agrochemical formulation comprising:
(a) at least one neonicotinoid in the suspended form;
(b) at least one pyrethroid in the partly solubilized form;
(c) at least a solubilizing medium allowing higher amount of active ingrédient in the partly solubilized form;
(d) at least an aromatic hydrocarbon preventing active ingrédient in the partly solubilized form from freezing at sub-zero degree celcius; and optionally one or more agrochemically acceptable excipients.
3. The formulation as claimed in claim 2 wherein, said neonicotinoids active ingrédient is selected from acetamiprid, imidacloprid, clothianidin, dinotefuran, nithiazine, thiacloprid and thiamethoxam.
4. The formulation as claimed in claim 3 wherein said active ingrédient is selected from acetamiprid and imidacloprid.
5. The formulation as claimed in claim 3 wherein said active ingrédient in the suspended form is présent from about 0.1% to about 90% of the total weight of the formulation.
6. The formulation as claimed in claim 2 wherein pyrethroids active ingrédient in the partly solubilized form is selected from cypermethrin, fenvalerate, permethrin, alphacypermethrin, betacypermethrin, zetacypermethrin, deltamethrin, cyfluthrin, bifenthrin, lambda-cyhalothrin, bioresmethrin and mixtures thereof.
7. The formulation as claimed in claim 7 wherein, said active ingrédient présent is bifenthrin.
8. The formulation as claimed in claim 7 wherein said active ingrédient is présent from about 0.1% to about 90% of the total weight of the formulation.
9. The formulation as claimed in claim 1 wherein, said solubilizing medium is selected from the group comprising of one or more paraffin, petroleum, ketone, vegetable oil, synthetically modified vegetable oil, alkyl esters of vegetable oil, modified vegetable oil, diesel, minerai oil, fatty acid, their dérivative and/or combinations or mixture thereof.
10. The formulation as claimed in claim 1 wherein, said solubilizing medium is présent from about 5% to about 90% of the total weight of the formulation.
11. The formulation as claimed in claim 1 wherein, said aromatic hydrocarbon is selected from the group comprising of toluene, o-, m-, p-xylene, dodecane, n-decane, n-hexane, benzene, ethylbenzene, isopropylbenzene, tert-butylbenzene, naphthalenes, mono- or polyalkyl-substituted naphthalenes, heavy aromatic naphthalene depleted (Aromatic 200, 100, 150) or mixtures thereof.
12. The formulation as claimed in claim 1 wherein, said aromatic hydrocarbon is présent from about 1% to about 60% of the total weight of the formulation.
13. The formulation as claimed in claim 1 wherein, said formulation is stable at sub-zero température, preferably at 0 °C and below 0 °C.
14. The formulation as claimed in claim 1 wherein, said formulation has particle size distribution Dio of less than about 1.5 microns, D5o of less than about 5.0 microns and D9o of less than or equal to about 30 microns.
15. A process for préparation of a stable liquid agrochemical formulation comprising (a) at least one active ingrédient in the suspended form; (b) at least one active ingrédient in the partly solubilized form; (c) at least a solubilizing medium allowing higher amount of active ingrédient in the partly solubilized form; (d) at least one aromatic hydrocarbon preventing active ingrédient in the partly solubilized form from freezing at sub-zero degree celcius; and optionally one or more agrochemically acceptable excipients, wherein said process comprising steps of:
a) adding at least one active ingrédient to be in the partly solubilized form in the mixture of solubilizing medium and aromatic hydrocarbon;
b) adding at least one active ingrédient to be in the suspended form in the mixture;
c) milling the mixture obtained in step (ii) until'desired particle size is achieved.
16. The formulation as claimed in claim 1 wherein, said formulation is used as pest control solution.
17. A method of controlling or preventing unwanted pests on plants or propagation material thereof, said method comprising applying an agrochemically effective amount of a stable liquid agrochemical formulation to the pests or to their locus wherein composition comprising:
a) at least one active ingrédient in the suspended form;
b) at least one active ingrédient in the partly solubilized form;
c) at least a solubilizing medium allowing higher amount of active ingrédient in the partly solubilized form;
d) at least an aromatic hydrocarbon preventing active ingrédient in the partly solubilized form from freezing at sub-zero degree celcius;
and optionally one or more agrochemically acceptable excipients.
OA1202100017 2018-07-26 2019-07-18 A stable liquid agrochemical formulation. OA20007A (en)

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