US20170354630A1 - Methods of Treating Multiple Sclerosis - Google Patents

Methods of Treating Multiple Sclerosis Download PDF

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Publication number
US20170354630A1
US20170354630A1 US15/527,252 US201515527252A US2017354630A1 US 20170354630 A1 US20170354630 A1 US 20170354630A1 US 201515527252 A US201515527252 A US 201515527252A US 2017354630 A1 US2017354630 A1 US 2017354630A1
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US
United States
Prior art keywords
fumarate
patient
pharmaceutical composition
foregoing
administering
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US15/527,252
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English (en)
Inventor
Mark Novas
Rui (Ray) Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biogen MA Inc
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Biogen MA Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54771192&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=US20170354630(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biogen MA Inc filed Critical Biogen MA Inc
Priority to US15/527,252 priority Critical patent/US20170354630A1/en
Publication of US20170354630A1 publication Critical patent/US20170354630A1/en
Assigned to BIOGEN MA INC. reassignment BIOGEN MA INC. CHANGE OF ASSIGNEE ADDRESS Assignors: BIOGEN MA INC.
Abandoned legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225Polycarboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542Carboxylic acids, e.g. a fatty acid or an amino acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545Heterocyclic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/0004Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816Wall or shell material
    • A61K9/4825Proteins, e.g. gelatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/485Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4858Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4866Organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/487Physical analysis of biological material of liquid biological material
    • G01N33/49Blood
    • G01N33/492Determining multiple analytes
    • GPHYSICS
    • G09EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09BEDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
    • G09B19/00Teaching not covered by other main groups of this subclass
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
US15/527,252 2014-11-17 2015-11-16 Methods of Treating Multiple Sclerosis Abandoned US20170354630A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US15/527,252 US20170354630A1 (en) 2014-11-17 2015-11-16 Methods of Treating Multiple Sclerosis

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462080783P 2014-11-17 2014-11-17
US201562140255P 2015-03-30 2015-03-30
US201562232963P 2015-09-25 2015-09-25
US15/527,252 US20170354630A1 (en) 2014-11-17 2015-11-16 Methods of Treating Multiple Sclerosis
PCT/US2015/060850 WO2016081355A1 (en) 2014-11-17 2015-11-16 Methods of treating multiple sclerosis

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2015/060850 A-371-Of-International WO2016081355A1 (en) 2014-11-17 2015-11-16 Methods of treating multiple sclerosis

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US15/647,036 Continuation US20180000770A1 (en) 2014-11-17 2017-07-11 Methods of Treating Multiple Sclerosis
US15/647,016 Continuation US11129806B2 (en) 2014-11-17 2017-07-11 Methods of treating multiple sclerosis
US16/936,398 Continuation US11007166B2 (en) 2014-11-17 2020-07-22 Methods of treating multiple sclerosis

Publications (1)

Publication Number Publication Date
US20170354630A1 true US20170354630A1 (en) 2017-12-14

Family

ID=54771192

Family Applications (8)

Application Number Title Priority Date Filing Date
US15/527,252 Abandoned US20170354630A1 (en) 2014-11-17 2015-11-16 Methods of Treating Multiple Sclerosis
US15/647,036 Abandoned US20180000770A1 (en) 2014-11-17 2017-07-11 Methods of Treating Multiple Sclerosis
US15/647,016 Active US11129806B2 (en) 2014-11-17 2017-07-11 Methods of treating multiple sclerosis
US16/043,641 Abandoned US20190008817A1 (en) 2014-11-17 2018-07-24 Methods of Treating Multiple Sclerosis
US16/173,723 Active US10959972B2 (en) 2014-11-17 2018-10-29 Methods of treating multiple sclerosis
US16/936,398 Active US11007166B2 (en) 2014-11-17 2020-07-22 Methods of treating multiple sclerosis
US17/071,740 Active US11007167B2 (en) 2014-11-17 2020-10-15 Methods of treating multiple sclerosis
US17/321,788 Active US11246850B2 (en) 2014-11-17 2021-05-17 Methods of treating multiple sclerosis

Family Applications After (7)

Application Number Title Priority Date Filing Date
US15/647,036 Abandoned US20180000770A1 (en) 2014-11-17 2017-07-11 Methods of Treating Multiple Sclerosis
US15/647,016 Active US11129806B2 (en) 2014-11-17 2017-07-11 Methods of treating multiple sclerosis
US16/043,641 Abandoned US20190008817A1 (en) 2014-11-17 2018-07-24 Methods of Treating Multiple Sclerosis
US16/173,723 Active US10959972B2 (en) 2014-11-17 2018-10-29 Methods of treating multiple sclerosis
US16/936,398 Active US11007166B2 (en) 2014-11-17 2020-07-22 Methods of treating multiple sclerosis
US17/071,740 Active US11007167B2 (en) 2014-11-17 2020-10-15 Methods of treating multiple sclerosis
US17/321,788 Active US11246850B2 (en) 2014-11-17 2021-05-17 Methods of treating multiple sclerosis

Country Status (13)

Country Link
US (8) US20170354630A1 (ja)
EP (3) EP3804711A1 (ja)
JP (4) JP6786486B2 (ja)
KR (3) KR20240035912A (ja)
CN (6) CN113368091A (ja)
AU (3) AU2015350213A1 (ja)
CA (1) CA2967619C (ja)
EA (1) EA038370B1 (ja)
IL (2) IL269885B (ja)
MA (2) MA40985A (ja)
MX (1) MX2017006473A (ja)
WO (1) WO2016081355A1 (ja)
ZA (1) ZA201703207B (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10959972B2 (en) 2014-11-17 2021-03-30 Biogen Ma Inc. Methods of treating multiple sclerosis
US20220172370A1 (en) * 2020-11-27 2022-06-02 Vuno Inc. Method for detecting white matter lesions based on medical image

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US10391160B2 (en) 2014-03-14 2019-08-27 Biogen Ma Inc. Dimethyl fumarate and vaccination regimens
SG10201907291QA (en) 2015-02-08 2019-09-27 Alkermes Pharma Ireland Ltd Monomethylfumarate prodrug compositions
JP7012660B2 (ja) 2016-04-01 2022-02-14 ノームズ テクノロジーズ インコーポレイテッド リン含有修飾イオン性液体
JP7296893B2 (ja) 2017-07-17 2023-06-23 ノームズ テクノロジーズ インコーポレイテッド リン含有電解質
WO2020214693A1 (en) * 2019-04-17 2020-10-22 Ixchel Pharma, Llc Prodrugs of monomethyl fumarate
JP7224067B2 (ja) * 2019-05-31 2023-02-17 キュラクル カンパニー リミテッド フマル酸ジメチルを含有する腸溶性錠剤
CN111440771A (zh) * 2020-03-17 2020-07-24 中山大学附属第三医院 一种含有clcn2纯合突变的白质脑病患者特异诱导多能干细胞系
US20230172894A1 (en) 2020-05-06 2023-06-08 Imcyse Sa Combination treatment for fumarate-related diseases
KR102566549B1 (ko) * 2021-06-08 2023-08-14 제이투에이치바이오텍 (주) 3성분 프로드럭, 이의 약학적 조성물 및 의약 용도

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AU2015328676B2 (en) 2014-10-08 2017-07-20 Banner Life Sciences Llc Controlled release enteric soft capsules of fumarate esters
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10959972B2 (en) 2014-11-17 2021-03-30 Biogen Ma Inc. Methods of treating multiple sclerosis
US11007166B2 (en) 2014-11-17 2021-05-18 Biogen Ma Inc. Methods of treating multiple sclerosis
US11007167B2 (en) 2014-11-17 2021-05-18 Biogen Ma Inc. Methods of treating multiple sclerosis
US11129806B2 (en) 2014-11-17 2021-09-28 Biogen Ma Inc. Methods of treating multiple sclerosis
US20220172370A1 (en) * 2020-11-27 2022-06-02 Vuno Inc. Method for detecting white matter lesions based on medical image

Also Published As

Publication number Publication date
US20180000770A1 (en) 2018-01-04
CA2967619A1 (en) 2016-05-26
CN115501218A (zh) 2022-12-23
KR102299842B1 (ko) 2021-09-09
US20210315854A1 (en) 2021-10-14
EP3220907A1 (en) 2017-09-27
IL252296B (en) 2022-06-01
US10959972B2 (en) 2021-03-30
AU2015350213A1 (en) 2017-05-25
AU2021269298A1 (en) 2021-12-09
NZ731528A (en) 2021-11-26
US11007166B2 (en) 2021-05-18
US20190008817A1 (en) 2019-01-10
CN115531366A (zh) 2022-12-30
AU2020239734A1 (en) 2020-10-15
JP2020196760A (ja) 2020-12-10
US20170368013A1 (en) 2017-12-28
WO2016081355A1 (en) 2016-05-26
CN107106530A (zh) 2017-08-29
JP6786486B2 (ja) 2020-11-18
JP2022168243A (ja) 2022-11-04
JP6830941B2 (ja) 2021-02-17
US20200345679A1 (en) 2020-11-05
JP2017537089A (ja) 2017-12-14
CN113368093A (zh) 2021-09-10
KR20240035912A (ko) 2024-03-18
KR20170084270A (ko) 2017-07-19
EA201791101A1 (ru) 2017-12-29
MA40985A (fr) 2017-09-26
CN113368091A (zh) 2021-09-10
US11246850B2 (en) 2022-02-15
MA53882A (fr) 2021-12-08
MX2017006473A (es) 2018-01-30
US20190125710A1 (en) 2019-05-02
US20210023040A1 (en) 2021-01-28
CA2967619C (en) 2022-06-28
EA038370B1 (ru) 2021-08-17
IL269885B (en) 2022-06-01
US11129806B2 (en) 2021-09-28
IL252296A0 (en) 2017-07-31
CN113368092A (zh) 2021-09-10
EP3804711A1 (en) 2021-04-14
EP4215191A1 (en) 2023-07-26
US11007167B2 (en) 2021-05-18
JP2019023248A (ja) 2019-02-14
ZA201703207B (en) 2021-08-25
KR20210111362A (ko) 2021-09-10

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