US20140271788A1 - Sublingual and buccal film compositions - Google Patents

Sublingual and buccal film compositions Download PDF

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Publication number
US20140271788A1
US20140271788A1 US13/842,543 US201313842543A US2014271788A1 US 20140271788 A1 US20140271788 A1 US 20140271788A1 US 201313842543 A US201313842543 A US 201313842543A US 2014271788 A1 US2014271788 A1 US 2014271788A1
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United States
Prior art keywords
composition
antioxidant
chelator
film
agonist
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Abandoned
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US13/842,543
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English (en)
Inventor
Garry L. Myers
Eric Dadey
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Aquestive Therapeutics Inc
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MonoSol Rx LLC
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Publication date
Application filed by MonoSol Rx LLC filed Critical MonoSol Rx LLC
Priority to US13/842,543 priority Critical patent/US20140271788A1/en
Priority to US14/196,082 priority patent/US9511033B2/en
Priority to PCT/US2014/028568 priority patent/WO2014144241A1/en
Priority to DK14721650.1T priority patent/DK2968121T3/en
Priority to CN201480027179.8A priority patent/CN105491997B/zh
Priority to AU2014227693A priority patent/AU2014227693B2/en
Priority to CA2906773A priority patent/CA2906773C/en
Priority to MX2015013184A priority patent/MX2015013184A/es
Priority to KR1020157028424A priority patent/KR20160029730A/ko
Priority to EP14721650.1A priority patent/EP2968121B1/en
Priority to RU2015143647A priority patent/RU2015143647A/ru
Priority to BR112015023725A priority patent/BR112015023725A2/pt
Priority to JP2016502836A priority patent/JP6448096B2/ja
Priority to MYPI2015703198A priority patent/MY181159A/en
Publication of US20140271788A1 publication Critical patent/US20140271788A1/en
Assigned to MONOSOL RX, LLC reassignment MONOSOL RX, LLC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: MYERS, GARRY L., DADEY, ERIC
Priority to IL241441A priority patent/IL241441B/en
Priority to ZA2015/07685A priority patent/ZA201507685B/en
Priority to US15/369,101 priority patent/US20170296482A1/en
Priority to US16/155,100 priority patent/US20190038570A1/en
Priority to US16/163,029 priority patent/US10285910B2/en
Priority to JP2018225191A priority patent/JP2019048882A/ja
Priority to US16/705,422 priority patent/US20200315984A1/en
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Definitions

  • the present invention relates to compositions, methods of manufacture, products and methods of use relating to films containing therapeutic actives.
  • the invention more particularly relates to self-supporting dosage forms which provide an agonist acting alone or in combination with a buffer system to maximize therapeutic absorption of the agonist.
  • Some embodiments also include an antagonist, with the buffer system acting to minimize the absorption of the antagonist.
  • Such compositions are particularly useful for preventing misuse of the active while providing sufficient buccal adhesion of the dosage form.
  • Oral administration of two therapeutic actives in a single dosage form can be complex if the intention is to have one active absorbed into the body and the other active remain substantially unabsorbed.
  • one active may be relatively soluble in the mouth at one pH, and the other active may be relatively insoluble at the same pH.
  • the absorption kinetics of each therapeutic agent may be substantially different due to differing absorption of the charged and uncharged species.
  • Co-administration of therapeutic agents has many applications.
  • areas of treatment include treating individuals who suffer from pain or other medical condition. Such individuals may have a tendency to suffer from serious physical dependence on the therapeutic agent, resulting in potentially dangerous withdrawal effects when the therapeutic agent is not administered to the individual.
  • a reduced level of a therapeutic agent which provides an effect of treating the condition, but does not provide the “high” that may be provided by the therapeutic agent.
  • the drug provided may be an agonist or a partial agonist, which may provide a reduction in pain or other symptom that the patient is experiencing.
  • these therapeutic agents provide only a low level of euphoric effect, they are capable of being abused by the individuals parenterally.
  • a combination of the therapeutic agent with a second therapeutic agent which may decrease the likelihood of diversion and abuse of the first drug.
  • a dosage of an antagonist in combination with the agonist or partial agonist it is known to provide a dosage of an antagonist in combination with the agonist or partial agonist.
  • the narcotic antagonist binds to a receptor in the brain to block the receptor, thus reducing the effect of the agonist.
  • narcotic agents has been marketed under the trade name Suboxone® as an orally ingestible tablet.
  • Suboxone® an orally ingestible tablet.
  • such combinations in tablet form have the potential for abuse.
  • the patient who has been provided the drug may store the tablet in his mouth without swallowing the tablet, then later extract the agonist from the tablet and inject the drug into an individual's body.
  • certain antagonists such as highly water-soluble antagonists
  • incorporation of an antagonist in combination with the pain-relieving agonist has been found to reduce side effects associated with administration of the agonist, such as constipation and other undesirable effects. It is desired to provide a dosage that cannot be easily removed from the mouth once it has been administered.
  • a self-supporting film dosage composition including: a polymeric carrier matrix; a therapeutically effective amount of an agonist or a pharmaceutically acceptable salt thereof; and a buffer sufficient to maximize the absorption of the agonist.
  • a self-supporting film dosage composition including a polymeric carrier matrix, a therapeutically effective amount of an agonist or a pharmaceutically acceptable salt thereof, a buffer sufficient to maximize the absorption of the agonist, and a chelator or antioxidant.
  • a self-supporting film dosage composition including a polymeric carrier matrix, a therapeutically effective amount of an agonist or a pharmaceutically acceptable salt thereof, a therapeutically effective amount of an antagonist or a pharmaceutically acceptable salt thereof, buffering system; and a chelator or an antioxidant, wherein said buffering system comprises a buffer capacity sufficient to inhibit the absorption of said antagonist during the time which said composition is in the oral cavity of a user.
  • a self-supporting film dosage composition including: a polymeric carrier matrix; a therapeutically effective amount of an agonist or a pharmaceutically acceptable salt thereof; a therapeutically effective amount of an antagonist or a pharmaceutically acceptable salt thereof; and a buffering system; where the buffering system possesses a buffer capacity sufficient to inhibit the absorption of the antagonist during the time which the composition is in the oral cavity of a user.
  • a method of treatment including the steps of: providing a film dosage composition including: a polymeric carrier matrix; a therapeutically effective amount of an agonist or a pharmaceutically acceptable salt thereof; and a buffer in an amount sufficient to maximize the absorption of the agonist; and administering the film dosage composition to a patient.
  • a method of treatment including the steps of: providing a film dosage composition including: a polymeric carrier matrix; a therapeutically effective amount of an agonist or a pharmaceutically acceptable salt thereof; a therapeutically effective amount of an antagonist or a pharmaceutically acceptable salt thereof; a first buffer in an amount sufficient to obtain a local pH of the agonist of about 4 to about 9; a buffer in an amount sufficient to obtain a local pH of the antagonist of about 2 to about 4; and administering the film dosage composition to a user.
  • a self-supporting film dosage composition including: a first region including: a first polymeric matrix; a therapeutically effective amount of an agonist or a pharmaceutically acceptable salt thereof; and a first buffering system in an amount sufficient to optimize the absorption of the agonist; a second region including: a second polymeric matrix; a therapeutically effective amount of an antagonist; and a second buffering system in an amount sufficient to inhibit the absorption of the antagonist.
  • an orally dissolving film formulation including a first region including a therapeutically effective amount of an agonist and second region including a therapeutically effective amount of an antagonist, where the formulation provides an in vivo plasma profile having a Cmax of about 0.868-6.94 ng/ml for the agonist and an in vivo plasma profile having a Cmax of about 32.5-260 pg/ml for the antagonist.
  • a self-supporting film dosage composition including: a polymeric carrier matrix; a therapeutically effective amount of an agonist or a pharmaceutically acceptable salt thereof; a therapeutically effective amount of an antagonist or a pharmaceutically acceptable salt thereof; and a buffering system sufficient to obtain a local pH of the antagonist of about 2 to about 4.
  • a self-supporting film dosage composition including: a polymeric carrier matrix; a therapeutically effective amount of an agonist or a pharmaceutically acceptable salt thereof; a therapeutically effective amount of an antagonist or a pharmaceutically acceptable salt thereof; and a buffering system sufficient to inhibit absorption of the antagonist and optimize absorption of the agonist when the film dosage composition is placed in the mouth of a user.
  • a self-supporting film dosage composition including: a first region including: a first polymeric matrix; a therapeutically effective amount of an agonist or a pharmaceutically acceptable salt thereof; and a first buffering system in an amount sufficient to optimize absorption of the agonist when the film dosage composition is placed in the mouth of a user; and a second region including: a second polymeric matrix; a therapeutically effective amount of an antagonist; and a second buffering system in an amount sufficient to inhibit absorption of the antagonist when the film dosage composition is placed in the mouth of a user.
  • a process of forming a film dosage composition including the steps of: casting a film-forming composition, the film-forming composition including: a polymeric carrier matrix; a therapeutically effective amount of an agonist or a pharmaceutically acceptable salt thereof; a therapeutically effective amount of an antagonist or a pharmaceutically acceptable salt thereof; and a buffer in an amount sufficient to optimize absorption of the agonist and sufficient to inhibit absorption of the antagonist when the film dosage composition is placed in the mouth of a user; and drying the film-forming composition to form a self-supporting film dosage composition.
  • a method of treatment including the steps of: providing a film dosage composition including: a polymeric carrier matrix; a therapeutically effective amount of an agonist or a pharmaceutically acceptable salt thereof; a therapeutically effective amount of an antagonist or a pharmaceutically acceptable salt thereof; and a buffering system in an amount sufficient to provide an in vivo plasma profile having a Cmax of about 0.624-5.638 ng/ml for the agonist and an in vivo plasma profile having a Cmax of less than 324 pg/ml for the antagonist; and administering the film dosage composition to a user.
  • a self-supporting film dosage composition including: a first region including: a first polymeric matrix; a therapeutically effective amount of an agonist or a pharmaceutically acceptable salt thereof; and a first buffering system in an amount sufficient to optimize the absorption of the agonist; a second region including: a second polymeric matrix; a therapeutically effective amount of an antagonist; and a second buffering system in an amount sufficient to inhibit the absorption of the antagonist; where the second region dissolves at a faster rate when placed in the oral cavity of the user than the first region.
  • a process of forming a film dosage composition including the steps of: casting a first film-forming composition, the first film-forming composition including: a polymeric carrier matrix; a therapeutically effective amount of an agonist or a pharmaceutically acceptable salt thereof; and a buffer in an amount sufficient to optimize absorption of the agonist when the film dosage composition is placed in the mouth of a user; casting a second film-forming composition, the second film-forming composition including: a polymeric carrier matrix; a therapeutically effective amount of an antagonist or a pharmaceutically acceptable salt thereof; and a buffer in an amount sufficient to inhibit absorption of the antagonist when the film dosage composition is placed in the mouth of a user; and laminating the first film-forming composition and the second film-forming composition together to form a self-supporting film dosage composition.
  • FIG. 1 shows a graph presenting the results of an EDTA concentration study.
  • the term Cmax refers to the mean maximum plasma concentration after administration of the composition to a human subject.
  • the term AUC refers to the mean area under the plasma concentration-time curve value after administration of the compositions formed herein.
  • the term “optimizing the absorption” does not necessarily refer to reaching the maximum absorption of the composition, and rather refers to reaching the optimum level of absorption at a given pH.
  • the “optimum” absorption may be, for example, a level that provides a bioequivalent absorption as administration of the currently available Suboxone® tablet.
  • the Cmax of buprenorphine may be about 0.67 to about 5.36 ng/ml at dosages of from 2-16 mg buprenorphine at a given pH.
  • an “optimum” AUC of buprenorphine may be about 7.43 to about 59.46 hr*ng/ml at dosages of from 2-16 mg buprenorphine at a given pH.
  • the absorption of one particular agonist, buprenorphine can provide an optimum absorption at a local pH of about 3-4 as well as about 5.5-6.5.
  • one may “optimize” the absorption of buprenorphine by providing a local pH of about 3-4 or about 5.5-6.5.
  • Maximizing the absorption refers to the maximum in vivo absorption values achieved at a local pH of about 4 to about 9.
  • local pH refers to the local pH of the region of the carrier matrix immediately surrounding the active agent as the matrix hydrates and/or dissolves, for example, in the mouth of the user.
  • inhibiting the absorption of an active, it is meant achieving as complete an ionization state of the active as possible, such that little to none of the active is measurably absorbable.
  • the Cmax of an active such as naloxone for dosage of 0.5 mg to 4.0 mg ranges from 32.5 to 260 pg/ml
  • an AUC of naloxone for dosage of 0.5 mg to 4.0 mg ranges from 90.55 to 724.4 hr*pg/ml. It is understood that at a local pH lower than 3.0, further ionization would be expected and thus result in lower absorption.
  • bioequivalent means obtaining 80% to 125% of the Cmax and AUC values for a given active in a different product. For example, assuming Cmax and AUC values of buprenorphine for a commercially-available Suboxone® tablet (containing 2 mg buprenorphine and 0.5 mg naloxone) are 0.780 ng/ml and 6.789 hr*ng/ml, respectively, a bioequivalent product would have a Cmax of buprenorphine in the range of 0.624-0.975 ng/ml, and an AUC value of buprenorphine of 5.431-8.486 hr*ng/ml.
  • film includes thin films, sheets and wafers, in any shape, including rectangular, square, or other desired shape.
  • the films described herein may be any desired thickness and size such that it may be placed into the oral cavity of the user.
  • the films may have a relatively thin thickness of from about 0.1 to about 10 mils, or they may have a somewhat thicker thickness of from about 10 to about 30 mils.
  • the thickness may be even larger, i.e., greater than about 30 mils.
  • Films may be in a single layer or they may be multi-layered, including laminated films.
  • Oral dissolving films generally fall into three main classes: fast dissolving, moderate dissolving and slow dissolving.
  • Fast dissolving films generally dissolve in about 1 second to about 30 seconds in the mouth.
  • Moderate dissolving films generally dissolve in about 1 to about 30 minutes in the mouth, and slow dissolving films generally dissolve in more than 30 minutes in the mouth.
  • Fast dissolving films may consist of low molecular weight hydrophilic polymers (i.e., polymers having a molecular weight between about 1,000 to 9,000, or polymers having a molecular weight below 200,000).
  • slow dissolving films generally have high molecular weight polymers (i.e., having a molecular weight in the millions).
  • Moderate dissolving films tend to fall in between the fast and slow dissolving films. Moderate dissolving films dissolve rather quickly, but also have a good level of mucoadhesion. Moderate dissolving films are also flexible, quickly wettable, and are typically non-irritating to the user. For the instant invention, it is preferable to use films that fall between the categories of fast dissolving and moderate dissolving. Such moderate dissolving films provide a quick enough dissolution rate, most desirably between about 1 minute and about 20 minutes, while providing an acceptable mucoadhesion level such that the film is not easily removable once it is placed in the oral cavity of the user.
  • Inventive films described herein may include one or more agonists or partial agonists.
  • the term “agonist” refers to a chemical substance that is capable of providing a physiological response or activity in the body of the user.
  • the films described herein may further include one or more antagonists.
  • the term “antagonist” refers to any chemical substance that acts within the body of the user to reduce the physiological activity of another chemical substance.
  • an antagonist used herein may act to reduce and/or block the physiological activity of the agonist.
  • the actives may be water-soluble, or they may be water-insoluble.
  • water-soluble refers to substances that are at least partially dissolvable in a solvent, including but not limited to water.
  • water-soluble does not necessarily mean that the substance is 100% dissolvable in the solvent.
  • water-insoluble refers to substances that are not readily dissolvable in a solvent, including but not limited to water. Solvents may include water, or alternatively may include other polar solvents by themselves or in combination with water.
  • the present invention relates to methods of treating pain or other symptoms in an individual while limiting the potential for abuse of the treatment. More desirably, the invention relates to the treatment of physical pain in an individual, for example by administration of an analgesic or other pain-relieving therapeutic agent.
  • One such therapeutic agent that is known to treat pain in individuals includes an agonist such as buprenorphine.
  • buprenorphine is known to be a partial agonist and therefore can be abused, and as such it is desired to combine buprenorphine with an antagonist, thereby lessening the potential for abuse by parenteral injection.
  • Such combination of drugs is currently provided via a product marketed under the trade name Suboxone®, which is an orally dissolvable tablet.
  • This tablet which provides a combination of buprenorphine (an opioid agonist) and naloxone (an opioid antagonist).
  • naloxone an opioid antagonist
  • the present invention provides a method of treating pain or other symptoms in a patient by providing an orally dissolvable film dosage, which provides a bioequivalent effect to Suboxone®.
  • the film dosage further preferably provides buccal adhesion while it is in the user's mouth, rendering it difficult to remove after placement.
  • the film dosage composition preferably includes a polymeric carrier matrix. Any desired polymeric carrier matrix may be used, provided that it is orally dissolvable. Desirably, the dosage should have enough bioadhesion to not be easily removed and it should form a gel like structure when administered.
  • the orally consumable films are preferably moderate-dissolving in the oral cavity and particularly suitable for delivery of actives, although both fast and sustained release compositions are also among the various embodiments contemplated.
  • the inventive combination may include films that have more than one region, where each region has a different dissolution profile.
  • the films used in the pharmaceutical products may be produced by a combination of at least one polymer and a solvent, optionally including other fillers known in the art.
  • the solvent may be water, a polar organic solvent including, but not limited to, ethanol, isopropanol, acetone, or any combination thereof.
  • the solvent may be a non-polar organic solvent, such as methylene chloride.
  • the film may be prepared by utilizing a selected casting or deposition method and a controlled drying process. For example, the film may be prepared through controlled drying processes, which include application of heat and/or radiation energy to the wet film matrix to form a visco-elastic structure, thereby controlling the uniformity of content of the film. Such processes are described in more detail in commonly assigned U.S. Pat.
  • the polymer included in the films may be water-soluble, water-swellable, water-insoluble, or a combination of one or more either water-soluble, water-swellable or water-insoluble polymers.
  • the polymer may include cellulose or a cellulose derivative.
  • useful water-soluble polymers include, but are not limited to, polyethylene oxide, pullulan, hydroxypropylmethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, polyvinyl pyrrolidone, carboxymethyl cellulose, polyvinyl alcohol, sodium alginate, polyethylene glycol, xanthan gum, tragancanth gum, guar gum, acacia gum, arabic gum, polyacrylic acid, methylmethacrylate copolymer, carboxyvinyl copolymers, starch, gelatin, and combinations thereof.
  • water-insoluble polymers include, but are not limited to, ethyl cellulose, hydroxypropyl ethyl cellulose, cellulose acetate phthalate, hydroxypropyl methyl cellulose phthalate and combinations thereof.
  • ethyl cellulose hydroxypropyl ethyl cellulose
  • cellulose acetate phthalate hydroxypropyl methyl cellulose phthalate
  • combinations thereof it may be desirable to incorporate a polymer which provides a high level of viscosity as compared to polymers suitable for lower dosages.
  • water-soluble polymer and variants thereof refer to a polymer that is at least partially soluble in water, and desirably fully or predominantly soluble in water, or absorbs water. Polymers that absorb water are often referred to as being water-swellable polymers.
  • the materials useful with the present invention may be water-soluble or water-swellable at room temperature and other temperatures, such as temperatures exceeding room temperature. Moreover, the materials may be water-soluble or water-swellable at pressures less than atmospheric pressure. Desirably, the water-soluble polymers are water-soluble or water-swellable having at least 20 percent by weight water uptake. Water-swellable polymers having a 25 or greater percent by weight water uptake are also useful. In some embodiments, films formed from such water-soluble polymers may be sufficiently water-soluble to be dissolvable upon contact with bodily fluids.
  • biodegradable polymers include materials that chemically degrade in the presence of a solvent, as opposed to materials that physically break apart (i.e., bioerodable materials).
  • poly(glycolic acid) PGA
  • poly(lactic acid) PLA
  • polydioxanes polyoxalates
  • poly( ⁇ -esters) polyanhydrides
  • polyacetates polycaprolactones
  • poly(orthoesters) polyamino acids
  • polyaminocarbonates polyurethanes
  • polycarbonates polyamides
  • poly(alkyl cyanoacrylates) poly(alkyl cyanoacrylates)
  • Additional useful polymers include, stereopolymers of L- and D-lactic acid, copolymers of bis(p-carboxyphenoxy) propane acid and sebacic acid, sebacic acid copolymers, copolymers of caprolactone, poly(lactic acid)/poly(glycolic acid)/polyethyleneglycol copolymers, copolymers of polyurethane and (poly(lactic acid), copolymers of polyurethane and poly(lactic acid), copolymers of ⁇ -amino acids, copolymers of ⁇ -amino acids and caproic acid, copolymers of ⁇ -benzyl glutamate and polyethylene glycol, copolymers of succinate and poly(glycols), polyphosphazene, polyhydroxy-alkanoates and mixtures thereof. Binary and ternary systems are contemplated.
  • lactide/glycolide 85/15 believed to be 85% lactide and 15% glycolide with a melting point within the range of 338°-347° F. (170°-175° C.); and lactide/glycolide 50/50, believed to be a copolymer of 50% lactide and 50% glycolide with a melting point within the range of 338°-347° F. (170°-175° C.).
  • Biodel materials represent a family of various polyanhydrides which differ chemically.
  • the time period for which it is desired to maintain the film in contact with the mucosal tissue depends on the type of active contained in the composition. Some actives may only require a few minutes for delivery through the mucosal tissue, whereas other actives may require up to several hours or even longer. Accordingly, in some embodiments, one or more water-soluble polymers, as described above, may be used to form the film.
  • water-soluble polymers and polymers that are water-swellable, water-insoluble and/or biodegradable may be desirable to use combinations of water-soluble polymers and polymers that are water-swellable, water-insoluble and/or biodegradable, as provided above.
  • the inclusion of one or more polymers that are water-swellable, water-insoluble and/or biodegradable may provide films with slower dissolution or disintegration rates than films formed from water-soluble polymers alone. As such, the film may adhere to the mucosal tissue for longer periods or time, such as up to several hours, which may be desirable for delivery of certain active components.
  • the individual film dosage has a small size that is between about 0.5-1 inch by about 0.5-1 inch. Most preferably, the film dosage is about 0.75 inches ⁇ 0.5 inches.
  • the film dosage should have good adhesion when placed in the buccal cavity or in the sublingual region of the user. Further, the film dosage should disperse and dissolve at a moderate rate, that is, between about 1 minute to about 30 minutes, and most desirably between about 10 minutes and about 20 minutes. In some embodiments, however, it may be desired to allow the individual film dosage to dissolve slower, over a period of longer than about 30 minutes. In such slow dissolving embodiments, it is preferable that the film dosage has strong mucoadhesion properties.
  • the film dosage should include components that aid in adhesion to the inner surface of the user's oral cavity, such as the buccal cavity or sublingually.
  • the region including the agonist should have a higher degree of adhesion than the region including the antagonist. In this fashion, the agonist may be released quicker and ingested by the user.
  • the films may include polyethylene oxide alone or in combination with a second polymer component.
  • the films may include polymers other than polyethylene oxide.
  • the second polymer may be another water-soluble polymer, a water-swellable polymer, a water-insoluble polymer, a biodegradable polymer or any combination thereof.
  • Suitable water-soluble polymers include, without limitation, any of those provided above.
  • the water-soluble polymer may include hydrophilic cellulosic polymers, such as hydroxypropyl cellulose and/or hydroxypropylmethyl cellulose.
  • water soluble polymers include, but are not limited to, polyethylene oxide (PEO), pullulan, hydroxypropyl cellulose, polydextrose, polyvinyl pyrrolidone, carboxymethyl cellulose, polyvinyl alcohol, sodium alginate, propylene glycol alginate, carrageenan, polyethylene glycol, xanthan gum, tragancanth gum, guar gum, acacia gum, arabic gum, polyacrylic acid, methylmethacrylate copolymer, poloxamer polymers, copolymers of acrylic acid and alkyl acrylate (available as Pemulen® polymers), carboxyvinyl copolymers, starch, gelatin, pectin, and combinations thereof.
  • PEO polyethylene oxide
  • pullulan pullulan
  • hydroxypropyl cellulose polydextrose
  • polyvinyl pyrrolidone carboxymethyl cellulose
  • polyvinyl alcohol sodium alginate
  • propylene glycol alginate carrageenan
  • water insoluble polymers include, but are not limited to, ethyl cellulose, hydroxypropyl ethyl cellulose, cellulose acetate phthalate, hydroxypropyl methyl cellulose phthalate, acrylic polymers, vinyl acetate, sodium sulphonated polyesters, carboxylated acrylics, trimethylpentanediol/adipic acid/glycerin cross polymer, polyglycerol-2-diisostearate/IPDI copolymer, carboxylated vinyl acetate copolymer, vinylpyrrolicone/vinyl acetate/alkylaminoacrylate terpolymers, vinylpyrrolidone/vinyl acetate copolymer, and combinations thereof.
  • polyethylene oxide may range from about 20% to 100% by weight in the polymer component, more specifically about 30% to about 70% by weight, and even more specifically about 40% to about 60% by weight.
  • one or more water-swellable, water-insoluble and/or biodegradable polymers also may be included in the polyethylene oxide-based film. Any of the water-swellable, water-insoluble or biodegradable polymers provided above may be employed.
  • the second polymer component may be employed in amounts of about 0% to about 80% by weight in the polymer component, more specifically about 30% to about 70% by weight, and even more specifically about 40% to about 60% by weight.
  • the molecular weight of the polyethylene oxide also may be varied.
  • high molecular weight polyethylene oxide such as about 4 million, may be desired to increase mucoadhesivity of the film.
  • the molecular weight may range from about 100,000 to 900,000, more specifically from about 100,000 to 600,000, and even more specifically from about 100,000 to 300,000.
  • it may be desirable to combine high molecular weight (600,000 to 900,000) with low molecular weight (100,000 to 300,000) polyethylene oxide in the polymer component.
  • Suitable polymers include those described in the applicant's co-pending application, U.S. Publication Number 2008-0260809, the entire contents of which are incorporated by reference herein.
  • optional components and fillers also may be added to the films. These may include, without limitation: surfactants; plasticizers; polyalcohols; anti-foaming agents, such as silicone-containing compounds, which promote a smoother film surface by releasing oxygen from the film; thermo-setting gels such as pectin, carageenan, and gelatin, which help in maintaining the dispersion of components; inclusion compounds, such as cyclodextrins and caged molecules; coloring agents; and flavors. In some embodiments, more than one active component may be included in the film.
  • Chelators may be included in the films. Applicants have surprisingly discovered that chelators may be employed to reduce or eliminate the oxidation of active ingredients in film compositions. In fact, chelators can be as effective as or even more effective than anti-oxidants in preventing or reducing oxidation of some actives, such as naloxone.
  • a chelator is added to the compositions of the present invention in the same manner as any other additive.
  • a chelator is added to one or more regions of a multi-region film.
  • a chelator is added to one or both regions of a dual region film.
  • the chelator may be the same in each region or may differ between regions.
  • the chelator may be any chelator known in the art.
  • Chelators have two functional groups that donate a pair of electrons such as ⁇ O, —NH2, —COO— and allow ring formation with metal.
  • Examples of chelators include, for example, ethylenediamineeteraacetic acid, proteins, polysaccharides, polynucleic acids, glutamic acid, histidine, organic diacids, polypeptides, phytochelatin, hemoglobin, chlorophyll, humic acid, phosphonates, transferrin, desferrioxamine, and combinations thereof.
  • the chelator is EDTA or a salt thereof.
  • Salts of EDTA include, for example, EDTA disodium salt, EDTA tetraammonium salt, EDTA tetrasodium salt, EDTA calcium disodium salt, EDTA tetrapotassium salt, EDTA diammonium salt.
  • the chelator is present in the film dosage compositions in an amount of about 0.1 to about 10% by weight of the total film dosage composition, preferably in an amount of 0.5 to about 7.5%, and more preferable in an amount of about 1 to about 2%.
  • the weight ratio of antagonist, such as naloxone, to chelator of about 0.2 to 2 to about 2 to 0.5, preferably in a weight ratio of 1 to 2 about 2 to 1.
  • Antioxidants may be included in the films. Antioxidants may be included in the films. Examples of such antioxidants include phenol antioxidants such as dibutylhydroxytoluene (BHT, IUPAC name: 2,6-bis(1,1-dimethylethyl)-4-methylphenol) and dibutylated hydroxyanisole (BHA); propyl gallate, sodium sulfate, citric acid, sodium metabusulfite, ascorbic acid, tocopherol, tocopherol ester derivatives, 2-mercaptobenzimidazole and the like.
  • BHT dibutylhydroxytoluene
  • BHA dibutylated hydroxyanisole
  • antioxidants preferred are ascorbic acid, dibutylhydroxytoluene (BHT), propyl gallate, sodium sulfite, citric acid, sodium metabisulfite, and combinations thereof.
  • the amount of an antioxidant to be used is preferably 0.1 to 20% by mass and more preferably 0.5 to 10% by mass per the total mass of the film dosage composition.
  • the film dosage composition either a chelator or an antioxidant. In another embodiment, the film dosage composition includes both a chelator and an antioxidant.
  • Additives may be included in the films.
  • classes of additives include excipients, lubricants, buffering agents, stabilizers, blowing agents, pigments, coloring agents, fillers, bulking agents, sweetening agents, flavoring agents, fragrances, release modifiers, adjuvants, plasticizers, flow accelerators, mold release agents, polyols, granulating agents, diluents, binders, buffers, absorbents, glidants, adhesives, anti-adherents, acidulants, softeners, resins, demulcents, solvents, surfactants, emulsifiers, elastomers and mixtures thereof. These additives may be added with the active ingredient(s).
  • Useful additives include, for example, gelatin, vegetable proteins such as sunflower protein, soybean proteins, cotton seed proteins, peanut proteins, grape seed proteins, whey proteins, whey protein isolates, blood proteins, egg proteins, acrylated proteins, water-soluble polysaccharides such as alginates, carrageenans, guar gum, agar-agar, xanthan gum, gellan gum, gum arabic and related gums (gum ghatti, gum karaya, gum tragancanth), pectin, water-soluble derivatives of cellulose: alkylcelluloses hydroxyalkylcelluloses and hydroxyalkylalkylcelluloses, such as methylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxyethylmethylcellulose, hydroxypropylmethylcellulose, hydroxybutylmethylcellulose, cellulose esters and hydroxyalkylcellulose esters such as cellulose acetate phthalate (CAP), hydroxypropylmethylcellulose (HPMC); carboxy
  • Such extenders may optionally be added in any desired amount desirably within the range of up to about 80%, desirably about 3% to 50% and more desirably within the range of 3% to 20% based on the weight of all film components.
  • Further additives may be flow agents and opacifiers, such as the oxides of magnesium aluminum, silicon, titanium, etc. desirably in a concentration range of about 0.02% to about 3% by weight and desirably about 0.02% to about 1% based on the weight of all film components.
  • plasticizers which include polyalkylene oxides, such as polyethylene glycols, polypropylene glycols, polyethylene-propylene glycols, organic plasticizers with low molecular weights, such as glycerol, glycerol monoacetate, diacetate or triacetate, triacetin, polysorbate, cetyl alcohol, propylene glycol, sorbitol, sodium diethylsulfosuccinate, triethyl citrate, tributyl citrate, and the like, added in concentrations ranging from about 0.5% to about 30%, and desirably ranging from about 0.5% to about 20% based on the weight of the polymer.
  • polyalkylene oxides such as polyethylene glycols, polypropylene glycols, polyethylene-propylene glycols, organic plasticizers with low molecular weights, such as glycerol, glycerol monoacetate, diacetate or triacetate, triacetin, polysorbate, cety
  • the starch material may further be added compounds to improve the texture properties of the starch material such as animal or vegetable fats, desirably in their hydrogenated form, especially those which are solid at room temperature.
  • animal or vegetable fats desirably in their hydrogenated form, especially those which are solid at room temperature.
  • These fats desirably have a melting point of 50° C. or higher.
  • tri-glycerides with C 12 -, C 14 -, C 16 -, C 18 -, C 20 - and C 22 -fatty acids.
  • These fats can be added alone without adding extenders or plasticizers and can be advantageously added alone or together with mono- and/or di-glycerides or phosphatides, especially lecithin.
  • the mono- and di-glycerides are desirably derived from the types of fats described above, i.e. with C 12 -, C 14 -, C 16 -, C 18 -, C 20 - and C 22 -fatty acids.
  • the total amounts used of the fats, mono-, di-glycerides and/or lecithins may be up to about 5% and preferably within the range of about 0.5% to about 2% by weight of the total film composition.
  • silicon dioxide calcium silicate, or titanium dioxide in a concentration of about 0.02% to about 1% by weight of the total composition. These compounds act as flow agents and opacifiers.
  • Lecithin is one surface active agent for use in the films described herein. Lecithin may be included in the feedstock in an amount of from about 0.25% to about 2.00% by weight.
  • Other surface active agents i.e. surfactants, include, but are not limited to, cetyl alcohol, sodium lauryl sulfate, the SpansTM and TweensTM which are commercially available from ICI Americas, Inc.
  • Ethoxylated oils including ethoxylated castor oils, such as Cremophor® EL which is commercially available from BASF, are also useful.
  • CarbowaxTM is yet another modifier which is very useful in the present invention. TweensTM or combinations of surface active agents may be used to achieve the desired hydrophilic-lipophilic balance (“HLB”).
  • HLB hydrophilic-lipophilic balance
  • binders which contribute to the ease of formation and general quality of the films.
  • binders include starches, pregelatinize starches, gelatin, polyvinylpyrrolidone, methylcellulose, sodium carboxymethylcellulose, ethylcellulose, polyacrylamides, polyvinyloxoazolidone, and polyvinylalcohols.
  • the film may include other additives, such as keratin, or proteins, including proteins that are useful in forming a gel, such as gelatine.
  • Such agents include solubility enhancing agents, such as substances that form inclusion compounds with active components. Such agents may be useful in improving the properties of very insoluble and/or unstable actives.
  • these substances are doughnut-shaped molecules with hydrophobic internal cavities and hydrophilic exteriors. Insoluble and/or instable actives may fit within the hydrophobic cavity, thereby producing an inclusion complex, which is soluble in water. Accordingly, the formation of the inclusion complex permits very insoluble and/or instable actives to be dissolved in water.
  • a particularly desirable example of such agents are cyclodextrins, which are cyclic carbohydrates derived from starch. Other similar substances, however, are considered well within the scope of the present invention.
  • Suitable coloring agents include food, drug and cosmetic colors (FD&C), drug and cosmetic colors (D&C), or external drug and cosmetic colors (Ext. D&C). These colors are dyes, their corresponding lakes, and certain natural and derived colorants. Lakes are dyes absorbed on aluminum hydroxide.
  • coloring agents include known azo dyes, organic or inorganic pigments, or coloring agents of natural origin.
  • Inorganic pigments are preferred, such as the oxides or iron or titanium, these oxides, being added in concentrations ranging from about 0.001 to about 10%, and preferably about 0.5 to about 3%, based on the weight of all the components.
  • Flavors may be chosen from natural and synthetic flavoring liquids.
  • An illustrative list of such agents includes volatile oils, synthetic flavor oils, flavoring aromatics, oils, liquids, oleoresins or extracts derived from plants, leaves, flowers, fruits, stems and combinations thereof.
  • a non-limiting representative list of examples includes mint oils, cocoa, and citrus oils such as lemon, orange, grape, lime and grapefruit and fruit essences including apple, pear, peach, grape, strawberry, raspberry, cherry, plum, pineapple, apricot or other fruit flavors.
  • aldehydes and esters such as benzaldehyde (cherry, almond), citral i.e., alphacitral (lemon, lime), neral, i.e., beta-citral (lemon, lime), decanal (orange, lemon), aldehyde C-8 (citrus fruits), aldehyde C-9 (citrus fruits), aldehyde C-12 (citrus fruits), tolyl aldehyde (cherry, almond), 2,6-dimethyloctanol (green fruit), and 2-dodecenal (citrus, mandarin), combinations thereof and the like.
  • aldehydes and esters such as benzaldehyde (cherry, almond), citral i.e., alphacitral (lemon, lime), neral, i.e., beta-citral (lemon, lime), decanal (orange, lemon), aldehyde C-8 (citrus fruits), aldeh
  • the sweeteners may be chosen from the following non-limiting list: glucose (corn syrup), dextrose, invert sugar, fructose, and combinations thereof; saccharin and its various salts such as the sodium salt; dipeptide sweeteners such as aspartame; dihydrochalcone compounds, glycyrrhizin; Stevia Rebaudiana (Stevioside); chloro derivatives of sucrose such as sucralose; sugar alcohols such as sorbitol, mannitol, xylitol, and the like.
  • hydrogenated starch hydrolysates and the synthetic sweetener 3,6-dihydro-6-methyl-1-1-1,2,3-oxathiazin-4-one-2,2-dioxide particularly the potassium salt (acesulfame-K), and sodium and calcium salts thereof, and natural intensive sweeteners, such as Lo Han Kuo.
  • Other sweeteners may also be used.
  • the films may include one or more additives to provide a taste masking of the active component.
  • the films may include ionic exchange resins, including but not limited to a water-insoluble organic or inorganic matrix material having covalently bound functional groups that are ionic or capable of being ionized under appropriate conditions.
  • the organic matrix may be synthetic (e.g., polymers or copolymers or acrylic acid, methacrylic acid, sulfonated styrene or sulfonated divinylbenzene) or partially synthetic (e.g., modified cellulose or dextrans).
  • the inorganic matrix may be, for example, silica gel modified by the addition of ionic groups. Most ion exchange resins are cross-linked by a crosslinking agent, such as divinylbenzene.
  • Anti-foaming and/or de-foaming components may also be used with the films. These components aid in the removal of air, such as entrapped air, from the film-forming compositions. Such entrapped air may lead to non-uniform films. Simethicone is one particularly useful anti-foaming and/or de-foaming agent. The present invention, however, is not so limited and other anti-foam and/or de-foaming agents may suitable be used.
  • simethicone and related agents may be employed for densification purposes. More specifically, such agents may facilitate the removal of voids, air, moisture, and similar undesired components, thereby providing denser, and thus more uniform films. Agents or components which perform this function can be referred to as densification or densifying agents. As described above, entrapped air or undesired components may lead to non-uniform films.
  • Simethicone is generally used in the medical field as a treatment for gas or colic in babies.
  • Simethicone is a mixture of fully methylated linear siloxane polymers containing repeating units of polydimethylsiloxane which is stabilized with trimethylsiloxy end-blocking unites, and silicon dioxide. It usually contains 90.5-99% polymethylsiloxane and 4-7% silicon dioxide. The mixture is a gray, translucent, viscous fluid which is insoluble in water.
  • simethicone When dispersed in water, simethicone will spread across the surface, forming a thin film of low surface tension. In this way, simethicone reduces the surface tension of bubbles air located in the solution, such as foam bubbles, causing their collapse.
  • the function of simethicone mimics the dual action of oil and alcohol in water. For example, in an oily solution any trapped air bubbles will ascend to the surface and dissipate more quickly and easily, because an oily liquid has a lighter density compared to a water solution. On the other hand, an alcohol/water mixture is known to lower water density as well as lower the water's surface tension. So, any air bubbles trapped inside this mixture solution will also be easily dissipated. Simethicone solution provides both of these advantages.
  • simethicone has an excellent anti-foaming property that can be used for physiological processes (anti-gas in stomach) as well as any for external processes that require the removal of air bubbles from a product.
  • the mixing step may be performed under vacuum. However, as soon as the mixing step is completed, and the film solution is returned to the normal atmosphere condition, air will be re-introduced into or contacted with the mixture. In many cases, tiny air bubbles will be again trapped inside this polymeric viscous solution.
  • the incorporation of simethicone into the film-forming composition either substantially reduces or eliminates the formation of air bubbles during and after mixing.
  • Simethicone may be added to the film-forming mixture as an anti-foaming agent in an amount from about 0.01 weight percent to about 5.0 weight percent, more desirably from about 0.05 weight percent to about 2.5 weight percent, and most desirably from about 0.1 weight percent to about 1.0 weight percent.
  • the dosage form includes at least one antagonist in addition to the agonist, it may be desired to control the release of the antagonist, so as to minimize or wholly prevent the absorption of the antagonist from the dosage form when taken orally.
  • the antagonist may be released faster and a larger proportion of it may be present as the ionized form in solution, thereby lessening the likelihood of its absorption in the body.
  • the dosage form is a self-supporting film composition, which is placed into the oral cavity of the user. In a dosage form that is to be placed in the oral cavity, it is desired to absorb the agonist buccally, so as to provide rapid absorption of the agonist into the body of the user.
  • any antagonist buccally it may be desired to inhibit or reduce absorption of any antagonist buccally, thereby allowing the antagonist to be swallowed and destroyed in the stomach, or in some cases absorbed in the colon.
  • Inhibiting the absorption of an antagonist may alternatively be achieved via physical means, such as by encapsulating the antagonist in a material that blocks absorption. It is desired, however, to reduce the absorption of the antagonist by chemical means, such as by controlling the local pH of the dosage form.
  • the local pH of the dosage form may be controlled.
  • the local pH may be controlled to a level that optimizes its release and/or absorption into the oral cavity of the user.
  • the local pH may be controlled to a level that maximizes the release and/or oral absorption of the agonist while simultaneously minimizing the release and/or oral absorption of the antagonist.
  • the film dosage may include distinct regions, one region including an agonist and the other region including an antagonist, where the local pH of each region is optimized for the desired effect.
  • the dosage form preferably includes a combination of an agonist and an antagonist, while the dosage has a controlled local pH.
  • the present invention is not limited to the use of any one particular agonist and/or antagonist, and any agonist (or partial agonist) and any antagonist may be incorporated into the present invention.
  • the agonist and optional antagonist should be selected from those agonists and antagonists that are useful in treating the particular symptom being treated.
  • the inventive films discussed herein are best suited for agonists and/or antagonists that are basic in nature.
  • Suitable antagonists (and/or partial antagonists) may include naloxone, naltrexone, nalorphin
  • Suitable agonists may have a pKa of about 5 to about 9.5, and most preferably from about 8.0 to about 9.0.
  • Suitable antagonists may have a pKa of about 6.0 to about 9.0, and most preferably about 7.0 to about 9.0.
  • naloxone has a pKa of about 7.94.
  • the dosage form is a self-supporting film.
  • the film dosage includes a polymer carrier matrix, a therapeutically effective amount of an agonist or a pharmaceutically acceptable salt thereof, and a buffer.
  • the agonist is a partial agonist, and most desirably the agonist is an opioid agonist, such as buprenorphine.
  • the buffer is preferably capable of providing a local pH of the composition within a range that provides a controllable level and desirably an optimal treatment level of absorption of the agonist. For example, it may be desired to provide an absorption of buprenorphine that is bioequivalent to a Suboxone® tablet.
  • certain agonists such as buprenorphine
  • the local pH for the film including the agonist may be either from about 3 to about 4 or from about 5 to about 9.
  • the local pH of the film composition may be about 5.5.
  • the local pH of the film composition may be about 6 to about 7.
  • the resulting dosage is a film composition that allows for a rapid and effective release of the agonist (such as buprenorphine) into the oral cavity of the user.
  • the film composition desirably has a sufficient adhesion profile, such that the film cannot easily be removed, or cannot be removed at all, from the oral cavity of the user once it has been placed into the cavity.
  • Full release of the agonist may take place within less than about thirty minutes, e.g., within about 10 minutes to about 30 minutes and preferably remains in the oral cavity for at least 1 minute and desirably about 1 to about 30 minutes.
  • the opioid agonist (or partial agonist) in the film composition with an opioid antagonist or a pharmaceutically acceptable salt thereof.
  • the agonist and antagonist may be dispersed throughout the dosage separately or the agonist and antagonist may be separately dispersed in individual film regions.
  • the antagonist includes naloxone, but any suitable antagonist may be selected as desired.
  • the antagonist may optionally be water-soluble, so as to render separation of the antagonist and agonist difficult, thereby lessening the potential for diversion abuse of the agonist.
  • a film including an agonist and an antagonist is desirably pH-controlled through the inclusion of a buffer.
  • a buffer At the desired local pH level of the agonist and the antagonist, optimal absorption of the agonist may be achieved while the absorption of the antagonist may be greatly inhibited.
  • the film may contain any desired level of self-supporting film forming polymer, such that a self-supporting film composition is provided.
  • the film composition contains a film forming polymer in an amount of at least 25% by weight of the composition.
  • the film forming polymer may alternatively be present in an amount of at least 50% by weight of the composition, and desirably in a range of about 25% to about 75%, and most desirably from about 30% to about 50% by weight of the composition.
  • any film forming polymers may be used as desired.
  • the film composition includes about 2 mg to about 16 mg of agonist per dosage. More desirably, the film composition includes about 4 mg to about 12 mg of agonist per dosage. If desired, the film composition may include about 0.5 mg to about 5 mg of antagonist per dosage. More desirably, the film composition includes about 1 mg to about 3 mg of antagonist per dosage. If an antagonist is incorporated into the film, the film composition may include the antagonist in a ratio of about 6:1-2:1 agonist to antagonist. Most desirably, the film composition contains about 4:1 agonist to antagonist per dosage. For example, in one embodiment, the dosage includes an agonist in an amount of about 12 mg, and includes an antagonist in an amount of about 3 mg.
  • the film compositions further desirably include at least one buffer so as to control the local pH of the film composition.
  • Any desired level of buffer may be incorporated into the film composition so as to provide the desired local pH level.
  • the buffer is preferably provided in an amount sufficient to control the release from the film and/or the absorption into the body of the agonist and the optional antagonist.
  • the film composition includes buffer in a ratio of buffer to agonist in an amount of from about 2:1 to about 1:5 (buffer:agonist).
  • the buffer may alternatively be provided in a 1:1 ratio of buffer to agonist.
  • a film composition including an antagonist preferably has a local pH of about 2 to about 4. Any buffer may be used as desired.
  • the buffer may include sodium citrate, citric acid, succinic acid, malic acid, phosphoric acid, boric acid, and combinations thereof.
  • the buffer may include a buffering system including a combination of components, such as Citric Acid/Sodium Citrate, Succinic Acid/Monosodium Succinate, Glycine/SodiumGlycine, Malic Acid/Sodium Malate, Phosphoric Acid/Sodium Phosphate, Fumaric Acid/Sodium Fumarate, Monosodium Phosphate/Disodium Phosphate, and Boric Acid/Sodium Borate.
  • the resulting film composition includes a polymer matrix, an agonist, and an optional antagonist, while the film composition has a controlled local pH to the level desired.
  • the buffer is desirably present in an amount to provide a therapeutically adequate absorption of the agonist, while simultaneously limiting or preventing substantial absorption of the antagonist. Controlling of the local pH allows for the desired release and/or absorption of the components, and thus provides a more useful and effective dosage.
  • the film dosage composition may include a polymer carrier matrix, a therapeutically effective amount of agonist, a therapeutically effective amount of antagonist, and a buffering system.
  • a “therapeutically effective amount” of an antagonist is intended to refer to an amount of the antagonist that is useful in diverting abuse of the agonist by a user.
  • the buffering system may include a buffer in addition to a solvent.
  • the buffering system desirably includes a sufficient level of buffer so as to provide a desired local pH level of the film dosage composition.
  • the buffer desirably has a buffer capacity sufficient to maintain ionization of the optional antagonist during the time that the composition is in the oral cavity of a user. Maintaining ionization of the antagonist serves to limit the absorption of the antagonist, and thus provide the desired control of the antagonist. While the ionization of the antagonist is limited, the ionization of the agonist may not be so limited. As such, the resulting dosage form provides absorption of the agonist to the user, while sufficiently reducing and/or preventing absorption of the antagonist.
  • the film dosage composition of the present invention may include an agonist in a sufficient amount so as to provide a release profile bioequivalent to a tablet containing a higher amount of the agonist.
  • an effective release and absorption of the agonist may be achieved with less of the agonist present in the dosage.
  • the film dosage composition may include an agonist in an amount that is at least 1.5 times less than the amount of the agonist required in a tablet, but still provides a bioequivalent release profile.
  • the agonist may be a partial agonist.
  • the agonist may be an opioid agonist.
  • the agonist includes buprenorphine or a pharmaceutically acceptable salt thereof.
  • the film dosage composition including an agonist may be configured to provide an in vivo plasma profile having a mean maximum plasma concentration (Cmax) in a desired range.
  • Cmax mean maximum plasma concentration
  • the desired Cmax may be a bioequivalent level to that of a Suboxone® tablet. It has been discovered by the Applicants that controlling the Cmax of the film composition allows one to control the absorption of the active (such as an agonist) into the user. The resulting film composition is more effective and suitable for delivery to a user.
  • the Cmax of the film composition may be about 6.4 ng/ml or less. If desired, the Cmax of the film composition may be less than about 5.2 ng/ml, less than about 3.8 ng/ml, less than about 1.9 ng/ml, or less than about 1.1 ng/ml, depending on the desired dosage level. In such embodiments, the agonist may be present in an amount of from about 2 mg to about 16 mg per dosage, or, if desired about 4 mg to about 12 mg per dosage. The agonist may include buprenorphine or a pharmaceutically acceptable salt thereof.
  • the film composition may include a mean AUC value of about 6.8 hr ⁇ ng/ml or greater.
  • the film composition may include a mean AUCinf value of from about 6.8 hr ⁇ ng/ml to about 66 hr ⁇ ng/ml.
  • the film compositions may include an optional antagonist.
  • the film composition may be configured to provide a particular Cmax and/or AUC for the antagonist.
  • the naloxone may be configured to provide a Cmax of less than about 400 pg/ml, less than about 318 pg/ml, less than about 235 pg/ml, less than about 92 pg/ml or less than about 64 pg/ml.
  • the naloxone may provide a mean AUC value of less than about 1030 hr ⁇ ng/ml.
  • the film composition may be prepared to provide a desired Cmax and/or AUC value for each of the agonist and antagonist.
  • a dosage having 16 mg of agonist and 4 mg of antagonist may provide an in vivo plasma profile having a Cmax of less than about 6.4 ng/ml for the agonist and an in vivo plasma profile having a Cmax of less than about 400 pg/ml for the antagonist.
  • Such formulation may also provide an AUC value of more than about 6.8 hr ⁇ ng/ml for the agonist.
  • the formulation may provide an AUCinf value of less than about 1030 hr ⁇ pg/ml for the antagonist.
  • compositions may include the agonist and the antagonist in any desired amount, and in a preferred embodiment, the composition includes about 2 mg to about 16 mg of the agonist per dosage and about 0.5 mg to about 4 mg of the antagonist per dosage. Most desirably, the agonist and antagonist are present in amounts of about 4:1 by weight agonist to antagonist.
  • a self-supporting film dosage composition including more than one region (referred to as a “dual-film product” or a “dual-region product”).
  • the multiple regions may be disposed on top of each other, to the side of each other, or disposed internally of each other.
  • the dosage composition may include two separate regions, disposed in such a configuration where the first region is on top of the second region, or vice versa. If desired, the two regions may be laminated to each other so as to provide a single dosage form.
  • the first region may be dried prior to laminating any additional regions thereto.
  • the second region may be dried prior to laminating the first region thereto.
  • either the first or second region may be at least partially dried prior to laminating any additional regions thereto.
  • a first region which includes a first polymeric matrix and a therapeutically effective amount of an agonist.
  • the agonist may be a partial agonist, and the agonist may be an opioid agonist.
  • One such opioid agonist includes buprenorphine, but any desired agonist may be used to treat the particular symptom desired.
  • the first region desirably includes a first buffering system in an amount sufficient to provide a local pH of the agonist so as to optimize the release and/or absorption of the agonist.
  • the first region may be in communication with a second region.
  • the second region may include a second polymeric matrix and a therapeutically effective amount of an antagonist.
  • One such antagonist includes naloxone, but any desired antagonist may be used as desired.
  • the second region may further include a second buffering system in an amount sufficient to provide a local pH of the antagonist so as to inhibit the absorption of the antagonist.
  • a second buffering system in an amount sufficient to provide a local pH of the antagonist so as to inhibit the absorption of the antagonist.
  • the first and second regions may work in cooperation to provide a desired absorption profile of the agonist and the antagonist.
  • the first buffering system may be present in an amount sufficient to provide increased absorption of the agonist, while the second buffering system is present in an amount sufficient to provide a decreased absorption of the antagonist.
  • the first buffering system may be present in an amount sufficient to provide a local pH of the first region so as to provide an optimum absorption of the agonist, i.e., of from either about 3 to about 4 or of from about 4 to about 9, and more specifically from about 6 to about 9.
  • the second buffering system may be present in an amount sufficient to provide a local pH of the second region of from about 2 to about 4, and more specifically about 2 to about 3.
  • the local pH of the buprenorphine region is desirably either from about 3 to about 4 or from about 5.5 to about 6.5, and the local pH of the naloxone region is about 2.0 to about 3.0.
  • the desired local pH level for each region may be greater or lower so as to optimize absorption of the agonist while inhibiting absorption of the antagonist.
  • the local pH of the agonist-containing region is desirably between about 4 to about 9, and most desirably about 6 to about 9.
  • the local pH for the antagonist-containing region is most desirably about 2 to about 4. Again, however, it will be understood that the particular agonist incorporated into the dosage may be more optimally absorbed at a higher or lower pH.
  • the first and second buffering systems may be the same or they may be different. Additionally, the first polymeric matrix and the second polymeric matrix may be the same or they may be different. Any desired levels of agonist and antagonist may be provided, and desirably the dosage composition includes about 2 mg to about 16 mg of the agonist and about 0.5 mg to about 4 mg of the antagonist per dosage unit. More desirably, the dosage composition includes about 4 mg to about 12 mg of the agonist and about 1 mg to about 3 mg of the antagonist per dosage unit.
  • the first and second regions may be formed together in any desired means.
  • the second region may be coated, sprayed, or placed onto at least one surface of the first region.
  • the first and second regions may be co-extruded.
  • the first and second regions may be laminated to each other by means of a suitable composition.
  • the first region may be formed first, and then subsequently dipped into a solution of a wet composition, which is then allowed to dry and form the second region.
  • the first region may include the antagonist while the second region includes the agonist.
  • both regions may include a desired amount of agonist and antagonist so as to provide a desired release and absorption.
  • the first region may include more components by weight than the second region, or vice versa.
  • the first region may have a total weight that is more than the total weight of the second region, or vice versa.
  • the first and second regions may include the same amount of components by weight.
  • a self-supporting film dosage composition having more than one region, where each region includes a polymeric matrix and a water-soluble and/or a water-insoluble active.
  • the dosage composition preferably includes a therapeutically effective amount of a water-soluble active and a therapeutically effective amount of water-insoluble active.
  • Each region preferably includes a buffer in an amount sufficient to control the absorption profiles of the water-soluble and water-insoluble actives in each region, depending on the desired level of absorption of the active desired.
  • a first buffer is present in the first region in an amount sufficient to obtain a local pH of one region of about 2 to about 4, while a second buffer is present in the second region in an amount sufficient to obtain a local pH of the second region of about 4 to about 9.
  • the present invention provides a method of treating various problems in a patient, including, for example physical pain experienced by a patient.
  • the patient is treated by providing a dosage to the patient, which provides an effective release of therapeutic active but simultaneously provides a suitable adhesion so that the dosage cannot be easily removed.
  • the dosage forms provided herein are particularly useful in preventing diversion of a drug.
  • an orally dissolvable film composition is provided to a patient.
  • the film composition may include one or more particular active components.
  • the film composition includes a polymer carrier matrix and a therapeutically effective amount of an agonist.
  • the agonist is a partial agonist.
  • the agonist may be an opioid agonist, such as buprenorphine or a pharmaceutically acceptable salt thereof.
  • the film composition preferably includes a buffer in an amount sufficient to control the local pH of the film composition. Any buffer or buffering system may be used, including those listed above. Desirably, the local pH of the film composition including an agonist is buffered to be about 4 to about 9, depending on the particular agonist included in the composition.
  • the desired local pH is about 5 to about 6.5, and most desirably the local pH is about 5.5 to about 6.5.
  • the absorption of the agonist may be optimized.
  • the film composition is administered to the patient, most desirably into the oral cavity of the patient, such as through buccal absorption.
  • the composition may include a therapeutically effective amount of an antagonist.
  • the antagonist may be any desired antagonist, and in one embodiment includes naloxone or a pharmaceutically acceptable salt thereof.
  • the film composition is preferably administered to patient through the oral cavity of the patient, but may be administered in any desired means.
  • the orally dissolvable film composition is then allowed to dissolve in the oral cavity of the patient for a sufficient time so as to release the active(s) therein.
  • the film composition may remain in the oral cavity for at least 30 seconds, and in some embodiments may remain in the oral cavity for at least 1 minute.
  • the film preferably becomes sufficiently adhered so as to render its removal difficult.
  • the active(s) are sufficiently released from the composition and allowed to take effect on the patient.
  • the administration of the dosage may have regions of differing dissolution rates.
  • the first region of the film composition may include an agonist and a moderate dissolving polymer.
  • the first region remains in the oral cavity for at least one minute, and up to about 30 minutes.
  • the second region which may include an antagonist, desirably contains a fast dissolving polymer.
  • the second region dissolves within less than one minute, thereby releasing the antagonist into the body where it is ingested and ionized. In this way, the antagonist is swallowed, thereby avoiding buccal absorption.
  • the antagonist is still present in the film composition before administration so as to limit potential abuse of the drug should a user attempt to extract the agonist from the composition.
  • the film dosage composition is formed via any desired process. Suitable processes are set forth in U.S. Pat. Nos. 7,425,292 and 7,357,891, the entire contents of which are incorporated by reference herein.
  • the film dosage composition is formed by first preparing a wet composition, the wet composition including a polymeric carrier matrix, a therapeutically effective amount of an agonist, and a buffer in an amount sufficient to control the local pH of the composition to a desired level.
  • the wet composition is cast into a film and then sufficiently dried to form a self-supporting film composition.
  • the wet composition may be cast into individual dosages, or it may be cast into a sheet, where the sheet is then cut into individual dosages.
  • the agonist may be a partial agonist.
  • the wet composition may include a therapeutically effective amount of an antagonist.
  • the local pH of the film may be about 2 to about 4, and more particularly between about 3 to about 4.
  • the agonist and the optional antagonist are preferably selected to treat a particular problem, such as treatment of physical pain suffered by a patient.
  • the agonist may include buprenorphine or a pharmaceutically acceptable salt thereof, while the antagonist may include naloxone or a pharmaceutically acceptable salt thereof.
  • the film composition includes at least one buffer or buffering system so as to control the local pH of the agonist and antagonist to desired levels. In this fashion, the absorption of the agonist may be optimized while the absorption of the antagonist may be inhibited.
  • the inventive film provides an absorption of the agonist that is bioequivalent to that of a Suboxone® tablet.
  • the local pH of the film composition should provide a local pH of the agonist of either between about 3 to about 4 or between about 5.5 to about 6.5, and a local pH of the antagonist of between about 2 to about 4.
  • the local pH is desirably about 3 to about 4 to provide a bioequivalent absorption to the Suboxone® tablet.
  • Active ingredients in pharmaceutical compositions can degrade and lose their effectiveness when included in a pharmaceutical composition and stored.
  • the active ingredient may oxidize into a form that is, for example, less bioavailable.
  • the film may be manufacture in whole or in part under an inert gas environment.
  • a preferred inert gas is nitrogen.
  • chelators may be employed to reduce or eliminate the oxidation of active ingredients in film compositions.
  • chelators are more effective than anti-oxidants in preventing or reducing oxidation of some actives, such as naloxone.
  • a chelator is added to the compositions of the present invention in the same manner as any other additive.
  • a chelator is added to one or more regions of a multi-region film.
  • a chelator is added to one or both regions of a dual region film.
  • the chelator may be the same in each region or may differ between regions.
  • Film strips including a combination of buprenorphine and naloxone were prepared.
  • Four different strength film compositions were prepared, which include a ratio of buprenorphine to naloxone of 16/4, 12/3, 8/2, and 2/0.5.
  • the compositions are summarized in Table 1 below.
  • the Cmax of buprenorphine is between about 0.624 and 5.638, and the AUC of buprenorphine is between about 5.431 to about 56.238.
  • the Cmax of naloxone is between about 41.04 to about 323.75, and the AUC of naloxone is between about 102.88 to about 812.00.
  • Film strips including a buprenorphine were prepared. Two different strength film compositions were prepared, which include buprenorphine in a dosage amount of 8 mg and in a dosage amount of 2 mg. The compositions are summarized in Table 4 below.
  • Buprenorphine Films Unit Formula Components (mg per film strip) Buprenorphine 8.64 2.16 Inactive Components Polyethylene Oxide, NF 17.66 21.87 (MW 100,000) Polyethylene Oxide, NF 2.17 2.35 (MW 900,000) Sugar Alcohol 5.43 6.72 Flavor 2.8 2.8 HPMC 1.9 2.69 Sweetener 1.2 1.2 Colorant 0.2 0.2 Total (mg) 40 40
  • Film dosages were prepared for use in an in vivo study to determine the bioavailability of buprenorphine/naloxone tablets and film formulations. Specifically, the films were tested to determine whether the film provides a bioequivalent effect to that of a tablet formulation.
  • Three film formulations including 8 mg buprenorphine and 2 mg naloxone were prepared, each being buffered to a different pH.
  • the first film did not include any buffer, providing a local pH of about 6.5.
  • the second was buffered to a local pH level of about 3-3.5.
  • the third was buffered to a local pH value of about 5-5.5.
  • Table 6 The formulations are set forth in Table 6 below.
  • the film dosage composition of film having a local pH of 6.5 was analyzed. Specifically, Test Formulation 1, as prepared in Example 5 was analyzed in vivo to determine the absorption of buprenorphine and of naloxone. The comparative film was compared to the absorption of buprenorphine and of naloxone provided by a one dose tablet (Suboxone®). The test film was compared to determine whether it provided a bioequivalent effect as the Suboxone® tablet.
  • Test Formulation 1 which had a local pH of about 6.5, as compared to the one dose tablet, are set forth in Tables 7 and 8 below.
  • the in vivo data indicates that buprenorphine is absorbed very well from the film formulation at a local pH of 6.5, and matched closely the absorption seen in the Suboxone® one dose tablet. However, the absorption was also maximized for the naloxone, which was undesirable. It was determined that a film having a combination of buprenorphine and naloxone and a local pH of 6.5 did not provide a bioequivalent effect as the one dose Suboxone® tablet for both buprenorphine and naloxone.
  • a film dosage composition of film having a local pH of 5-5.5 was analyzed.
  • Test Formulation 3 as prepared in Example 5 was analyzed in vivo to determine the absorption of buprenorphine and of naloxone.
  • the comparative films were compared to the absorption of buprenorphine and of naloxone provided by a one dose tablet (Suboxone®). The test film was compared to determine whether it provided a bioequivalent effect as the tablet product.
  • Test Formulation 3 which had a local pH of about 5-5.5, as compared to the one dose tablet, are set forth in Tables 9 and 10 below.
  • the in vivo data indicated that the absorption of buprenorphine increased as the local pH level decreased. It appeared that by decreasing the local pH from 6.5 to 5.5, the absorption of buprenorphine was being moved to a level much greater than that of the one dose Suboxone® tablet. In addition, the naloxone values did not provide a bioequivalent result as the one dose tablet. Thus, it was determined that the film having a local pH of 5.5 did not provide a bioequivalent result as that of the Suboxone® tablet for both buprenorphine and naloxone.
  • a film dosage composition of film having a local pH of about 3-3.5 was analyzed. It was assumed that the absorption of buprenorphine would continue to be increased as it had demonstrated at a local pH of 5.5. Thus, it was assumed that at a local pH of 3.5, the film would not be bioequivalent to that of the tablet.
  • Test Formulation 2 as prepared in Example 5, was analyzed in vivo to determine the absorption of buprenorphine and of naloxone.
  • the comparative films were compared to the absorption of buprenorphine and of naloxone provided by a one dose tablet (Suboxone®).
  • the test film was compared to determine whether it provided a bioequivalent effect as the tablet product.
  • Test Formulation 2 which had a local pH of about 3-3.5, as compared to the one dose tablet, are set forth in Tables 11 and 12 below.
  • the in vivo data indicated that the absorption of buprenorphine was substantially bioequivalent to that of the one dose tablet when the film composition local pH was lowered to about 3-3.5. This result was surprising as it did not appear to follow the pH partition theory. Further, at a local pH of about 3-3.5, it was seen that the absorption of naloxone was substantially bioequivalent to that of the one dose tablet.
  • the film product including buprenorphine and naloxone at a local pH of 3-3.5 was substantially bioequivalent to that of the Suboxone® one dose tablet. It was therefore evident that one could formulate the naloxone at a local pH of 3.5 or lower to inhibit its absorption, and formulate the buprenorphine at a local pH of about 5.5 to optimize its absorption.
  • the improvement from the 8/2 dose to the 2/0.5 dose (at a local pH of 3.5) demonstrates this importance.
  • the 8/2 dose has a ratio of acid/naloxone of 0.67, and this dose provided borderline acceptable bioequivalent results.
  • the 2/0.5 dose has a ratio of acid/naloxone of 2.68 at a local pH of 3.5, and provides a more bioequivalent absorption value than the 8/2 dose.
  • the data shows that the 2/0.5 dose at a local pH of 3.5 had an even lower buccal absorption than the one dose tablet, as seen from the normalized values for the AUC and Cmax.
  • the film product buffered at a local pH of 3.5 with a buffer ratio (buffer/naloxone) of 2.68 provides even better results than the Suboxone® formulation.
  • a dual-film dosage is prepared, with the first film layer having a local pH of about 3.5 and containing an antagonist therein, and the second film layer having a local pH of about 5.5 and containing an agonist therein.
  • the first film layer (having the antagonist) is a fast-dissolving film
  • the second film layer (having the agonist) is a moderate dissolving film.
  • the Cmax level for the Naloxone is between about 32.5 to about 260 pg/ml and the AUC for the Naloxone is between about 90.5 to about 724 hr*pg/ml.
  • varying types and levels of buffers may increase or decrease the absorption values. That is, when seeking to inhibit the absorption of the antagonist (i.e., naloxone), one may select a particular local pH for the agonist region and a second local pH for the antagonist region. The local pH of the region may depend on the amount of active included in that region. The amounts of actives incorporated into the dosage may be altered to provide suitable absorption levels, and may include amounts in milligrams, nanograms, picograms, or any desired amount of active.
  • EDTA ethylene diamine tetraacetic acid disodium salt
  • the appropriate EDTA level to protect naloxone from oxidation when used in the formulation of the 8/2 mg (buprenorphine/naloxone) film was studied. Samples of the 8/2 mg (buprenorphine/naloxone) films were produced with following amounts of EDTA: 4.0 mg, 2.0 mg, 1.0 mg, 0.2 mg, and no EDTA (control).
  • a 1 mg level of EDTA is sufficient to significantly reduce oxidation of naloxone in the film product.

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US13/842,543 US20140271788A1 (en) 2013-03-15 2013-03-15 Sublingual and buccal film compositions
US14/196,082 US9511033B2 (en) 2013-03-15 2014-03-04 Sublingual and buccal film compositions
BR112015023725A BR112015023725A2 (pt) 2013-03-15 2014-03-14 composição de dosagem de filme autossuportante, composição de dosagem de filme, método de tratamento, e, processo de formação de composição de dosagem de filme
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CN201480027179.8A CN105491997B (zh) 2013-03-15 2014-03-14 舌下及颊面膜组合物
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US15/369,101 US20170296482A1 (en) 2013-03-15 2016-12-05 Sublingual and buccal film compositions
US16/155,100 US20190038570A1 (en) 2013-03-15 2018-10-09 Sublingual and buccal film compositions
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IL241441B (en) 2019-07-31
US20170296482A1 (en) 2017-10-19
CA2906773A1 (en) 2014-09-18
AU2014227693A1 (en) 2015-10-29
CN105491997A (zh) 2016-04-13
WO2014144241A1 (en) 2014-09-18
CA2906773C (en) 2023-12-12
US20140271789A1 (en) 2014-09-18
US20200315984A1 (en) 2020-10-08
BR112015023725A2 (pt) 2017-07-18
JP6448096B2 (ja) 2019-01-09
DK2968121T3 (en) 2019-02-04
RU2015143647A (ru) 2017-04-21
KR20160029730A (ko) 2016-03-15
JP2019048882A (ja) 2019-03-28
EP2968121A1 (en) 2016-01-20
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AU2014227693B2 (en) 2018-06-21
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US20190038570A1 (en) 2019-02-07
ZA201507685B (en) 2017-06-28

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