US20130269684A1 - Methods and systems for supplying aerosolization devices with liquid medicaments - Google Patents
Methods and systems for supplying aerosolization devices with liquid medicaments Download PDFInfo
- Publication number
- US20130269684A1 US20130269684A1 US13/830,511 US201313830511A US2013269684A1 US 20130269684 A1 US20130269684 A1 US 20130269684A1 US 201313830511 A US201313830511 A US 201313830511A US 2013269684 A1 US2013269684 A1 US 2013269684A1
- Authority
- US
- United States
- Prior art keywords
- dispenser
- tip
- liquid medicament
- housing
- liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- GZRWINDJVTVNQB-UHFFFAOYSA-N C1C2C(CCCC3)C3C2C1 Chemical compound C1C2C(CCCC3)C3C2C1 GZRWINDJVTVNQB-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0085—Inhalators using ultrasonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/005—Sprayers or atomisers specially adapted for therapeutic purposes using ultrasonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2209/00—Ancillary equipment
- A61M2209/04—Tools for specific apparatus
- A61M2209/045—Tools for specific apparatus for filling, e.g. for filling reservoirs
Definitions
- inhalers for aerosolizing liquids.
- U.S. Pat. No. 5,586,550 incorporated herein by reference, describes an inhaler that comprises a dispensing apparatus in which a membrane with tapered apertures is vibrated such that liquid in contact with a rear face of the membrane is dispensed from a front face of the membrane as an aerosol.
- Other examples of single dose inhaler systems and medicaments that may be aerosolized are described in U.S. Patent Publication Nos. 2011/0168172 and 2001/0168170, the disclosures of which are herein incorporated by reference.
- One aspect of such inhalers is the need to supply a metered amount of liquid medicament to the dispensing apparatus so that the metered amount may be aerosolized and delivered to the patient's lungs.
- delivering a known quantity of a liquid medicament has proven to be challenging, particularly when the metered quantity needs to be dispensed in a controlled and repeatable fashion.
- this invention relates to ways for delivering such medicaments to inhalers for subsequent aerosolizing.
- One embodiment provides a method for supplying a metered amount of a liquid medicament to an aerosolizing device in a repeatable manner.
- the method utilizes an aerosolization device comprising a housing having a mouthpiece, a vibratable member within the housing and disposed to eject liquid droplets through the mouthpiece, a reservoir to hold the liquid medicament until aerosolized by the vibratable member, and an opening in the housing and in communication with the chamber. While described in connection with one specific type of inhaler, it will be appreciated that other types of aerosolization devices could be used with the methods described herein.
- a dispenser To supply a metered amount of liquid medicament, a dispenser is used that comprises an elongate dispenser body having a proximal end and a tip at a distal end through which a liquid medicament is dispensed. The dispenser further comprises a dispensing mechanism that operates to dispense a metered quantity of the liquid medicament from the tip each time the dispenser body is compressed.
- the dispenser may be grasped with one hand such that the fingers wrap around the dispenser body, with the thumb closest to the proximal end and the last or pinky finger closest to the tip.
- the tip of the dispenser is inserted into the opening in the housing. Then, while grasping the dispenser in the manner described, the elongate body is forced toward the tip to cause the dispenser body to compress, thereby operating the dispensing mechanism and causing a metered quantity of the liquid medicament to eject into the chamber each time the dispenser body is compressed.
- the process may be repeated for as many times as is needed to supply the prescribed amount into the chamber. This may be done with a “pumping action” where the user “pumps” the dispenser (causing it to compress with each pump), until the correct number of pumps have been supplied. For example, if the prescription calls for a certain volume of the liquid medicament, the dispenser may be pumped five times, with each pump dispensing a droplet having a metered volume of one-fifth the total volume.
- the tip may include at least one alignment feature that assists to keep the dispenser generally perpendicular to the housing while dispensing the liquid medicament.
- the invention provides an exemplary aerosolization system.
- the system includes an aerosolization device comprising a housing having a mouthpiece, a vibratable member within the housing and disposed to eject liquid droplets through the mouthpiece, a reservoir to hold the liquid medicament until aerosolized by the vibratable member, and an opening in the housing that is in fluid communication with the chamber.
- the system further includes a dispenser comprising an elongate dispenser body having a proximal end and a tip at a distal end through which a liquid medicament is dispensed.
- the dispenser further comprises a dispensing mechanism that operates to dispense a metered quantity of the liquid medicament from the tip each time the dispenser body is compressed.
- the dispenser is separate from the housing so that it may be manually interfaced with the aerosolization device.
- the opening defines an interface that engages with the tip such that when the tip is inserted into the opening, the interface stabilizes the dispenser in an upright orientation outside of the housing to permit the dispenser to be grasped with one hand to dispense the medicament.
- this orientation permits a user to wrap the fingers around the dispenser body, with the thumb closest to the proximal end and the last finger closest to the tip, and while grasping the dispenser, forcing the elongate body toward the tip to cause the dispenser body to compress, thereby operating the dispensing mechanism and causing a metered quantity of the liquid medicament to eject into the chamber each time the dispenser body is compressed.
- the tip may include at least one alignment feature that assists to keep the dispenser generally perpendicular to the top surface of the housing while dispensing the liquid medicament.
- This alignment feature may comprise a circular step around the tip, a plurality of tabs protruding from the tip, and the like.
- the invention provides an exemplary method for supplying a metered amount of a liquid medicament to an aerosolizing device.
- the method utilizes an aerosolization device comprising a housing having a mouthpiece, a vibratable member within the housing and disposed to eject liquid droplets through the mouthpiece, and a reservoir to hold the liquid medicament until aerosolized by the vibratable member.
- the housing also includes a top surface and an opening in the top surface of the housing. The opening is in fluid communication with the chamber.
- the method also utilizes a dispenser that comprises an elongate dispenser body having a proximal end and a tip at a distal end through which a liquid medicament is dispensed.
- the dispenser further comprises a dispensing mechanism that operates to dispense a metered quantity of the liquid medicament from the tip each time the dispenser body is compressed.
- the tip is inserted into the opening in the housing such that the dispenser body is generally perpendicular to the top surface of the housing and is seated within the opening such that the dispenser body is self-standing outside of the housing.
- the dispenser body may be compressed to operate the dispensing mechanism and cause a metered quantity of the liquid medicament to eject into the chamber each time the dispenser body is compressed.
- the dispenser may be repeatedly compressed to dispense multiple metered quantities of the liquid medicament into the chamber.
- the tip may include one or more alignment features that assist to keep the dispenser generally perpendicular to the housing while dispensing the liquid medicament so that it may be aerosolized.
- FIG. 1 illustrates one method for grasping a dispenser in preparation for delivering a metered amount of liquid medicament to an aerosolizing apparatus.
- FIG. 2 illustrates the dispenser of FIG. 1 when inserted into the aerosolizing apparatus and compressed in order to deliver the liquid medicament.
- FIG. 3 illustrates the dispenser of FIG. 1 when initially inserted into the aerosolizing apparatus of FIG. 1 .
- FIG. 4 illustrates the dispenser of FIG. 3 when compressed or pumped to deliver the liquid medicament.
- FIG. 5 is a cross sectional side view of another embodiment of an aerosolizing apparatus according to the invention.
- FIG. 6 illustrates another embodiment of a dispenser having ribs to facilitate positioning of the dispenser.
- Certain aspects of the invention relate to techniques for dispensing metered quantities of a liquid medicament into an aerosolizing apparatus, also referred to as an inhaler.
- an aerosolizing apparatus also referred to as an inhaler.
- the liquid will be dispensed into an aerosolizing apparatus comprising a housing defining a dispensing outlet or mouthpiece, a vibratable membrane or mesh having a front face exposed at the outlet and a rear face for receiving a liquid to be dispensed, and a vibrating mechanism connected to the housing and operable to vibrate the membrane to dispense aerosol of the liquid through the membrane.
- a variety of containers or dispensers may be used to store the liquid medicament, then to deliver a metered quantity of the liquid into a reservoir where it will contact the rear face of the membrane. In this way, a metered quantity of liquid is dispensable at the outlet or mouthpiece by operating the vibrating mechanism for an operating period sufficient to completely aerosolize the metered quantity at the rear face.
- the containers or dispensers will typically have a sealed region where the liquid is stored and a mechanism for dispensing a metered amount of liquid each time the mechanism is operated. For example, the container may be compressed or pumped to eject a droplet of a known volume.
- Exemplary aerosol generators that may be used in such inhalers are also described in U.S. Pat. Nos. 5,164,740; 6,629,646; 6,926,208; 7,108,197; 5,938,117; 6,540,153; 6,540,154; 7,040,549; 6,921,020; 7,083,112; 7,628,339; 5,586,550; 5,758,637; 6,085,740; 6,467,476; 6,640,804; 7,174,888; 6,014,970; 6,205,999; 6,755,189; 6,427,682; 6,814,071; 7,066,398; 6,978,941; 7,100,600; 7,032,590; 7,195,011, and in U.S.
- the aerosol generators may comprise vibratable membranes having tapered aperture with a size in the range from about 3 ⁇ m to about 8 ⁇ m, preferably from about 3 ⁇ m to about 6 ⁇ m, and in some cases around 4 ⁇ m.
- the membrane may be domed shaped and be vibrated by an annular piezoelectric element that circumscribes the apertures.
- the diameter of the membrane may be in the range from about 5 mm to about 8 mm.
- the membrane may also have a thickness in the range from about 50 microns to about 70 microns. Typically, the membrane will be vibrated at a frequency in the range from about 50 kHz to about 150 kHz.
- liquid medicaments may be dispensed from the container.
- the liquid medicament may comprise an insulin formulation, such as a preservative free insulation, including any of those described in U.S. Patent Publication No. 2011/0168170, previously incorporated by reference.
- a preservative free insulin formulation that may be dispensed may be free of any preservatives, including phenol, metacresol, chloro-cresol, thymol and mixtures thereof or the like.
- preservatives enable the formulations to be aerosolized as a liquid spray using a vibrating mesh or aperture plate that operates at high frequencies.
- the absence of such preservatives permits a dosage of the formulation to come into contact with the vibrating mesh without substantial foaming of the formulation.
- the formulation may be aerosolized more quickly. Further, substantially all of the liquid is able to be aerosolized.
- Such formulations contain water in major and human insulin in minor amount.
- the formulations may also include various concentrations of human insulin. For example, the concentrations may be in the range from about 100 IU insulin/ml of formulation to about 1200 IU insulin/ml of formulation, and more preferably from about 200 IU insulin/ml of formulation to about 800 IU insulin/ml of formulation.
- the formulations may also include zinc, acetate, chloride and sodium. The zinc ion and acetate ion come from the drug substance, e.g., the insulin.
- the chloride ion and sodium ion are added during dissolution of the insulin and adjustment of the pH.
- the NaCl concentration may be about 20 mM for an 800 IU insulin/ml formulation, about 10 mM for a 400 IU insulin/ml formulation, and about 5 mM for a 200 IU insulin/ml formulation.
- liquid medicaments may also be dispensed.
- medicaments could include other protein formulations, asthma and COPD treatments, vaccines and pain relief treatments.
- FIG. 1 Shown in FIG. 1 is an inhaler 10 that is constructed of a housing 12 having a mouthpiece 14 . Disposed within the housing is an aerosol generator comprising a vibratable mesh similar to those described herein, as well as electronics to control operation of the aerosol generator. The mesh is positioned to eject an aerosol through mouthpiece 16 when the mesh is vibrated.
- Housing 12 includes a top surface 13 with a slidable cover 18 is positioned over an opening 20 (see FIG. 2 ). Cover 18 is slid back is to expose opening 20 . Further, opening 20 leads to a reservoir 22 or funnel (see FIGS.
- mesh 24 has a rear face that is exposed to reservoir 22 so that when liquid is supplied to reservoir 22 it comes into contact with the rear face of mesh 24 .
- mesh 24 is vibrated (by actuating an “on” button 26 that energizes the aerosol generator) the liquid is ejected from the front face of mesh 24 as an atomized spray and is available for inhalation through mouthpiece 14 .
- FIG. 5 illustrates the internal components of an inhaler 100 that is similar to inhaler 10 as previously described.
- Inhaler 100 is constructed of a housing 112 that includes an opening 120 leads to a reservoir 122 that has an open bottom end 150 that funnels the dispensed liquid onto the rear face of a vibratable mesh (not shown) that is part of an aerosol generator 154 that has a vibratable element 155 (such as an annular piezoelectric transducer) that vibrates the mesh.
- Aerosol generator 154 has a circular opening 156 across which the mesh is disposed. When vibrated, the mesh ejects the liquid as an aerosolized spray into a capture chamber and to a mouthpiece. In this way, the aerosolized spray may be inhaled by inhaling from the mouthpiece.
- the liquid to be aerosolized is stored in a dispenser 30 that is best illustrated in FIGS. 3 and 4 .
- Dispenser 30 may conveniently be described in terms of a proximal end 32 and a distal end 34 that terminates in a tip 36 .
- Dispenser 30 further includes a canister 38 that stores the liquid medicament in a sterile environment.
- Dispenser 30 includes an internal valve such that distal end 34 may be moved relative to proximal end 32 , thus compressing dispenser 30 . In so doing, each time dispenser 30 is compressed (or “pumped”) a metered volume of liquid is ejected into reservoir 22 .
- FIG. 3 shows dispenser 30 in an uncompressed state.
- FIG. 3 shows dispenser 30 in an uncompressed state.
- FIG. 3 shows dispenser 30 in an uncompressed state.
- FIG. 3 shows dispenser 30 in an uncompressed state.
- dispenser 30 may be removed and stored for future use.
- Exemplary unit volumes that may be dispensed with each pump may be in the range from about 5 to about 100 microliters.
- Tip 36 includes a shoulder 40 in the shape of an annular or circular step that serves as a stop to prevent further insertion of tip 36 into opening 20 .
- Shoulder 40 is inset by a distance that is sufficient so that it not only serves as a stop by also permits tip 36 to seat within opening 20 in a stable position that is generally vertical to the top surface 13 of housing 12 . As such, once dispenser 30 is placed into opening 20 , it will be self-standing in a generally vertical orientation. This position permits a user to easily grasp the disperser 30 when ready to dispense a unit volume of the liquid to the aerosol generator.
- other seating mechanisms could be used, such as a taper that matches with the taper of opening 20 , protruding tabs or wings, detents, and the like.
- dispenser 30 is grasped with one hand, such that the four fingers wrap around dispenser 30 , mostly about canister 38 .
- a firm grip is achieved so that dispenser 30 may easily be pumped to eject the liquid.
- the person's thumb may rest on proximal end 32 to apply a further compressive force.
- cover 18 may be slid back and tip 34 placed into opening 20 .
- tip 34 includes a shoulder 40 that is wider than opening 20 so as to prevent tip 34 from coming into contact with mesh 24 .
- shoulder 40 may be designed so that tip 34 is sufficiently spaced-apart from mesh 24 so that when the full metered amount of the liquid is dispensed into reservoir 22 , tip 34 does not come into contact with the dispensed liquid. In this way, when dispenser 30 is removed from the inhaler, it will not also remove some of the dispensed liquid.
- tip 34 will be spaced apart from mesh 24 by a distance that is in the range from about 5 mm to about 20 mm.
- Tip 34 may also be tapered, such as to match the taper of reservoir 22 . The taper of reservoir 22 facilitates delivery of all the dispensed liquid onto the rear face of mesh 24 , and the tapering of tip 34 prevents it from coming into contact with the walls of reservoir 22 .
- tip 34 With tip 34 in place, the user presses canister 38 toward tip 34 . At the same time, inhaler 10 is held in place. This causes dispenser 30 to compress. In turn, the internal valve is opened to permit a metered amount of liquid to be dispensed from tip 34 and into reservoir 22 . Each time canister 38 is pressed downward, or pumped, another metered amount of liquid is ejected. This maneuver is performed as many times as is needed in order to supplied the prescribed dosage into reservoir 22 .
- dispenser 30 By holding the dispenser 30 in the manner shown, this pumping action may easily occur.
- a nasal spray dispenser that is typically actuated in an upright manner by carefully and simultaneously compressing the proximal end with the middle and index finger (with the tip extending between the fingers) to the distal end of the dispenser container, that is held under equal pressure by the thumb.
- the spray occurs when sufficient pressure is applied equally to both ends.
- dispenser 30 can be easily actuated by applying pressure solely to the distal end of the dispenser when the tip is engaged with the inhaler device.
- the inhaler device and mating features are constructed so that a metered amount of medicament is consistently delivered from the dispenser into the device and the user may do so with unregulated pressure, provided the force is greater than or equal to that required to compress the dispenser throughout its full range. If the inhaler device is loaded while placed on a table or any other freely supported surface, the force required to compress the dispenser into the device to the point of actuation is reduced by 50 % when compared to the amount of force required to disperse a volume of liquid when holding both the device and dispenser (without the aid of a support surface).
- FIG. 6 illustrates an alternative embodiment of a dispenser 80 that may be used with inhaler 10 or inhaler 100 .
- Dispenser 80 has a tip 82 at its distal end with multiple alignment features 84 that assist to properly align and position tip 82 within opening 20 in top surface 13 .
- Alignment features 84 may have a variety of shapes, sizes and configurations. Although shown with four equally spaced apart features 84 , it will be appreciated that other numbers may be used, such as only a single alignment feature.
- Features 84 serve as stops to limit insertion of tip 82 into opening 20 .
- Features 84 also provide a tactile feel to let the user know when tip 82 has been properly inserted.
- dispenser 80 When all four features 84 engage the surface of inhaler 10 , dispenser 80 has been properly inserted and is ready to have a metered amount dispensed into inhaler 10 . Further, features 84 serve to hold dispenser 80 in a generally vertical or perpendicular orientation relative to top surface 13 . In this way, dispenser 80 is self-standing when inserted into opening 20 to make it easier for a user to grasp and dispense as described in connection with FIGS. 1 and 2 .
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Anesthesiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Biophysics (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Special Spraying Apparatus (AREA)
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/830,511 US20130269684A1 (en) | 2012-04-16 | 2013-03-14 | Methods and systems for supplying aerosolization devices with liquid medicaments |
PCT/US2013/034359 WO2013158353A1 (en) | 2012-04-16 | 2013-03-28 | Methods and systems for supplying aerosolization devices with liquid medicaments |
EP13778248.8A EP2838592B1 (de) | 2012-04-16 | 2013-03-28 | Verfahren und systeme zur versorgung von aerosolbildungsvorrichtungen mit flüssigen medikamenten |
BR112014025878A BR112014025878B8 (pt) | 2012-04-16 | 2013-03-28 | Método para suprir uma quantidade dosada de um medicamento líquido a um dispositivo de aerossolização, e, sistema de aerossolização |
CN201380031665.2A CN104470567B (zh) | 2012-04-16 | 2013-03-28 | 向雾化装置提供液体药物的方法和系统 |
RU2014145836A RU2637285C2 (ru) | 2012-04-16 | 2013-03-28 | Способы и системы подачи жидких лекарственных средств в устройства распыления |
US16/133,484 US11786676B2 (en) | 2010-01-12 | 2018-09-17 | Methods and systems for supplying aerosolization devices with liquid medicaments |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261624531P | 2012-04-16 | 2012-04-16 | |
US13/830,511 US20130269684A1 (en) | 2012-04-16 | 2013-03-14 | Methods and systems for supplying aerosolization devices with liquid medicaments |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US15/165,662 Continuation-In-Part US10525214B2 (en) | 2010-01-12 | 2016-05-26 | Preservative-free single dose inhaler system |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US16/133,484 Continuation US11786676B2 (en) | 2010-01-12 | 2018-09-17 | Methods and systems for supplying aerosolization devices with liquid medicaments |
Publications (1)
Publication Number | Publication Date |
---|---|
US20130269684A1 true US20130269684A1 (en) | 2013-10-17 |
Family
ID=49323950
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/830,511 Abandoned US20130269684A1 (en) | 2010-01-12 | 2013-03-14 | Methods and systems for supplying aerosolization devices with liquid medicaments |
US16/133,484 Active 2031-09-04 US11786676B2 (en) | 2010-01-12 | 2018-09-17 | Methods and systems for supplying aerosolization devices with liquid medicaments |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US16/133,484 Active 2031-09-04 US11786676B2 (en) | 2010-01-12 | 2018-09-17 | Methods and systems for supplying aerosolization devices with liquid medicaments |
Country Status (6)
Country | Link |
---|---|
US (2) | US20130269684A1 (de) |
EP (1) | EP2838592B1 (de) |
CN (1) | CN104470567B (de) |
BR (1) | BR112014025878B8 (de) |
RU (1) | RU2637285C2 (de) |
WO (1) | WO2013158353A1 (de) |
Cited By (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017015017A1 (en) * | 2015-07-17 | 2017-01-26 | R. J. Reynolds Tobacco Company | Contained liquid system for refilling aerosol delivery devices |
WO2017137928A1 (en) * | 2016-02-12 | 2017-08-17 | Rai Strategic Holdings, Inc. | Adapters for refilling an aerosol delivery device |
US10076613B2 (en) | 2010-01-12 | 2018-09-18 | Dance Biopharm Inc. | Preservative free insulin formulations |
US20180293878A1 (en) * | 2015-10-06 | 2018-10-11 | Thorn Security Limited | Smoke detector tester |
US10307550B2 (en) | 2014-06-09 | 2019-06-04 | Dance Biopharm Inc. | Liquid drug cartridges and associated dispenser |
US10471222B2 (en) | 2014-07-01 | 2019-11-12 | Dance Biopharm Inc. | Aerosolization system with flow restrictor and feedback device |
WO2019239217A1 (en) * | 2018-06-14 | 2019-12-19 | Nexvap Sa | Electromechanical apparatus and method for using a mobile inhaler |
US20200353186A1 (en) * | 2017-11-08 | 2020-11-12 | Pneuma Respiratory, Inc. | Electronic breath actuated in-line droplet delivery device with small volume ampoule and methods of use |
US10842951B2 (en) | 2010-01-12 | 2020-11-24 | Aerami Therapeutics, Inc. | Liquid insulin formulations and methods relating thereto |
US10857313B2 (en) | 2014-07-01 | 2020-12-08 | Aerami Therapeutics, Inc. | Liquid nebulization systems and methods |
WO2021003277A1 (en) | 2019-07-03 | 2021-01-07 | Aerami Therapeutics, Inc. | Exenatide compositions for pulmonary administration and use thereof |
US10888117B2 (en) | 2018-10-18 | 2021-01-12 | Respira Technologies, Inc. | Apparatus for producing an aerosol for inhalation by a person |
US20210106772A1 (en) * | 2018-04-02 | 2021-04-15 | Pneuma Respiratory, Inc. | Handheld digital nebulizer device and methods of use |
US20210228824A1 (en) * | 2020-01-29 | 2021-07-29 | Aerami Therapeutics, Inc. | Wicking cap and methods |
US11096990B2 (en) | 2015-02-25 | 2021-08-24 | Aerami Therapeutics, Inc. | Liquid insulin formulations and methods relating thereto |
US11246338B2 (en) * | 2019-09-26 | 2022-02-15 | Dmitry Yankelevich | Device for smoking tobacco and other inhalation materials |
US11273271B2 (en) | 2014-07-01 | 2022-03-15 | Aerami Therapeutics, Inc. | Aerosolization system with flow restrictor and feedback device |
US11291779B2 (en) * | 2016-07-15 | 2022-04-05 | Koninklijke Philips N.V. | Aerosolization device and an aerosol drug delivery device |
US11517685B2 (en) | 2019-01-18 | 2022-12-06 | Qnovia, Inc. | Electronic device for producing an aerosol for inhalation by a person |
US11690963B2 (en) | 2018-08-22 | 2023-07-04 | Qnovia, Inc. | Electronic device for producing an aerosol for inhalation by a person |
US11998686B2 (en) | 2022-10-10 | 2024-06-04 | Rai Strategic Holdings, Inc. | Contained liquid system for refilling aerosol delivery devices |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20130269684A1 (en) | 2012-04-16 | 2013-10-17 | Dance Pharmaceuticals, Inc. | Methods and systems for supplying aerosolization devices with liquid medicaments |
CA2909714C (en) * | 2013-04-16 | 2023-08-29 | Dance Biopharm Inc. | Liquid dispensing and methods for dispensing liquids |
ES2734570T3 (es) * | 2013-04-16 | 2019-12-10 | Dance Biopharm Inc | Distribución de líquido |
EP3407943B1 (de) * | 2016-01-25 | 2020-04-08 | Philip Morris Products S.a.s. | Kartuschenanordnung mit einem betätigungsabschnitt |
FR3102934B1 (fr) * | 2019-11-12 | 2022-06-03 | Aptar France Sas | Dispositif de distribution de produit fluide |
Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1947310A (en) * | 1933-04-07 | 1934-02-13 | Warren M Sample | Liquid dispenser |
US3874380A (en) * | 1974-05-28 | 1975-04-01 | Smithkline Corp | Dual nozzle intranasal delivery device |
US5385180A (en) * | 1994-06-09 | 1995-01-31 | Empak, Inc. | Liquid saver funnel system |
US5487378A (en) * | 1990-12-17 | 1996-01-30 | Minnesota Mining And Manufacturing Company | Inhaler |
WO1998022290A1 (en) * | 1996-11-18 | 1998-05-28 | Pbt International Ltd. | An inkjet cartridge refill device |
US6257454B1 (en) * | 1998-05-02 | 2001-07-10 | Ing. Erich Pfeiffer Gmbh | Media dispenser |
US6748946B1 (en) * | 1998-09-26 | 2004-06-15 | Smithkline Beecham Corporation | Inhalation device |
US20040154617A1 (en) * | 2002-09-27 | 2004-08-12 | Dietmar Enk | Fiberoptic nebulizer |
US7600511B2 (en) * | 2001-11-01 | 2009-10-13 | Novartis Pharma Ag | Apparatus and methods for delivery of medicament to a respiratory system |
US7886783B2 (en) * | 2009-05-22 | 2011-02-15 | The General Electric Company | Anesthetic vaporizer filling system |
US20110168172A1 (en) * | 2010-01-12 | 2011-07-14 | Dance Pharmaceuticals, Inc. | Preservative-free single dose inhaler systems |
Family Cites Families (143)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2463922A (en) * | 1946-02-15 | 1949-03-08 | William E Turner | Liquid dispenser with receptacle operated outlet valve |
GB1383761A (en) | 1971-02-25 | 1974-02-12 | Woodcraft Dc | Inhalation device for use with an aerosol container |
US4771769A (en) * | 1982-12-20 | 1988-09-20 | Schering Corporation | Hand held metered spray dispenser |
US4564129A (en) | 1983-01-27 | 1986-01-14 | Hoechst-Roussel Pharmaceuticals Inc. | Dosage dispensing unit |
DE3339180C2 (de) * | 1983-10-28 | 1993-10-14 | Pfeiffer Erich Gmbh & Co Kg | Austragvorrichtung für Medien |
DE3734306A1 (de) * | 1987-10-10 | 1989-04-27 | Pfeiffer Erich Gmbh & Co Kg | Austragvorrichtung fuer fliessfaehige medien |
US5152456A (en) | 1989-12-12 | 1992-10-06 | Bespak, Plc | Dispensing apparatus having a perforate outlet member and a vibrating device |
US5060642A (en) | 1990-01-05 | 1991-10-29 | Gilman Thomas H | Wound dressing with air permeable bacteria impermeable reservoir |
GB9015077D0 (en) | 1990-07-09 | 1990-08-29 | Riker Laboratories Inc | Inhaler |
GB9026191D0 (en) * | 1990-12-01 | 1991-01-16 | Harris Pharma Ltd | Breath actuated dispensing device |
US6629646B1 (en) | 1991-04-24 | 2003-10-07 | Aerogen, Inc. | Droplet ejector with oscillating tapered aperture |
US5938117A (en) | 1991-04-24 | 1999-08-17 | Aerogen, Inc. | Methods and apparatus for dispensing liquids as an atomized spray |
US6540154B1 (en) | 1991-04-24 | 2003-04-01 | Aerogen, Inc. | Systems and methods for controlling fluid feed to an aerosol generator |
US5164740A (en) | 1991-04-24 | 1992-11-17 | Yehuda Ivri | High frequency printing mechanism |
US7628339B2 (en) | 1991-04-24 | 2009-12-08 | Novartis Pharma Ag | Systems and methods for controlling fluid feed to an aerosol generator |
US5363842A (en) | 1991-12-20 | 1994-11-15 | Circadian, Inc. | Intelligent inhaler providing feedback to both patient and medical professional |
US5333106A (en) | 1992-10-09 | 1994-07-26 | Circadian, Inc. | Apparatus and visual display method for training in the power use of aerosol pharmaceutical inhalers |
GB2272389B (en) | 1992-11-04 | 1996-07-24 | Bespak Plc | Dispensing apparatus |
US6024090A (en) | 1993-01-29 | 2000-02-15 | Aradigm Corporation | Method of treating a diabetic patient by aerosolized administration of insulin lispro |
US5364838A (en) | 1993-01-29 | 1994-11-15 | Miris Medical Corporation | Method of administration of insulin |
US7448375B2 (en) | 1993-01-29 | 2008-11-11 | Aradigm Corporation | Method of treating diabetes mellitus in a patient |
US5915378A (en) | 1993-01-29 | 1999-06-29 | Aradigm Corporation | Creating an aerosolized formulation of insulin |
US5888477A (en) | 1993-01-29 | 1999-03-30 | Aradigm Corporation | Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin |
US5672581A (en) | 1993-01-29 | 1997-09-30 | Aradigm Corporation | Method of administration of insulin |
US5743250A (en) | 1993-01-29 | 1998-04-28 | Aradigm Corporation | Insulin delivery enhanced by coached breathing |
US5694919A (en) | 1993-01-29 | 1997-12-09 | Aradigm Corporation | Lockout device for controlled release of drug from patient-activated dispenser |
US6131567A (en) | 1993-01-29 | 2000-10-17 | Aradigm Corporation | Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin |
CH686872A5 (de) | 1993-08-09 | 1996-07-31 | Disetronic Ag | Medizinisches Inhalationsgeraet. |
US5479920A (en) | 1994-03-01 | 1996-01-02 | Vortran Medical Technology, Inc. | Breath actuated medicinal aerosol delivery apparatus |
US5586550A (en) | 1995-08-31 | 1996-12-24 | Fluid Propulsion Technologies, Inc. | Apparatus and methods for the delivery of therapeutic liquids to the respiratory system |
US6782886B2 (en) | 1995-04-05 | 2004-08-31 | Aerogen, Inc. | Metering pumps for an aerosolizer |
US6014970A (en) | 1998-06-11 | 2000-01-18 | Aerogen, Inc. | Methods and apparatus for storing chemical compounds in a portable inhaler |
US6085740A (en) | 1996-02-21 | 2000-07-11 | Aerogen, Inc. | Liquid dispensing apparatus and methods |
US5758637A (en) | 1995-08-31 | 1998-06-02 | Aerogen, Inc. | Liquid dispensing apparatus and methods |
US6205999B1 (en) | 1995-04-05 | 2001-03-27 | Aerogen, Inc. | Methods and apparatus for storing chemical compounds in a portable inhaler |
US6427682B1 (en) | 1995-04-05 | 2002-08-06 | Aerogen, Inc. | Methods and apparatus for aerosolizing a substance |
US5809997A (en) | 1995-05-18 | 1998-09-22 | Medtrac Technologies, Inc. | Electronic medication chronolog device |
US5823179A (en) | 1996-02-13 | 1998-10-20 | 1263152 Ontario Inc. | Nebulizer apparatus and method |
US6790178B1 (en) | 1999-09-24 | 2004-09-14 | Healthetech, Inc. | Physiological monitor and associated computation, display and communication unit |
US6712762B1 (en) | 1997-02-28 | 2004-03-30 | Ors Diagnostic, Llc | Personal computer card for collection of real-time biological data |
US20060239930A1 (en) | 1997-08-04 | 2006-10-26 | Herbert Lamche | Process for nebulizing aqueous compositions containing highly concentrated insulin |
US6440929B1 (en) | 1998-07-27 | 2002-08-27 | Emisphere Technologies, Inc. | Pulmonary delivery of active agents |
US6234167B1 (en) | 1998-10-14 | 2001-05-22 | Chrysalis Technologies, Incorporated | Aerosol generator and methods of making and using an aerosol generator |
US6312665B1 (en) | 1998-12-21 | 2001-11-06 | Generex Pharmaceuticals Incorporated | Aerosol formulations for buccal and pulmonary application |
US6164498A (en) * | 1999-09-01 | 2000-12-26 | Mcneil-Ppc. Inc. | Pump dispenser |
US6235177B1 (en) | 1999-09-09 | 2001-05-22 | Aerogen, Inc. | Method for the construction of an aperture plate for dispensing liquid droplets |
DE60035212T2 (de) | 1999-10-01 | 2008-02-21 | Glaxo Group Ltd., Greenford | System zum überwachen von patientendaten |
CN2406684Y (zh) | 1999-11-26 | 2000-11-22 | 北京亚都科技股份有限公司 | 医用雾化器 |
GB0003197D0 (en) | 2000-02-11 | 2000-04-05 | Aid Medic Ltd | Improvements in and relating to controlling drug delivery |
GB2360219A (en) | 2000-03-18 | 2001-09-19 | Astrazeneca Uk Ltd | Inhaler |
US7100600B2 (en) | 2001-03-20 | 2006-09-05 | Aerogen, Inc. | Fluid filled ampoules and methods for their use in aerosolizers |
US6948491B2 (en) | 2001-03-20 | 2005-09-27 | Aerogen, Inc. | Convertible fluid feed system with comformable reservoir and methods |
US6626171B2 (en) | 2000-05-12 | 2003-09-30 | Iep Pharmaceutical Devices Inc. | Powder/liquid metering valve |
JP4147234B2 (ja) | 2004-09-27 | 2008-09-10 | キヤノン株式会社 | 吐出用液体、吐出方法、カートリッジ及び吐出装置 |
GB2368061B (en) | 2000-10-20 | 2005-05-11 | Gw Pharmaceuticals Ltd | Dose dispensing apparatus |
CN2461580Y (zh) | 2001-02-09 | 2001-11-28 | 鲁崇恭 | 超声波雾化胰岛素吸入装置 |
US6546927B2 (en) | 2001-03-13 | 2003-04-15 | Aerogen, Inc. | Methods and apparatus for controlling piezoelectric vibration |
WO2002074372A2 (en) | 2001-03-15 | 2002-09-26 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Nebulizer having cooling chamber |
US6732944B2 (en) | 2001-05-02 | 2004-05-11 | Aerogen, Inc. | Base isolated nebulizing device and methods |
EP1423046B2 (de) | 2001-08-13 | 2015-03-25 | Novo Nordisk A/S | System zur steuerung von drahtlosen dateninformationen zwischen zwei tragbaren medizinischen vorrichtungen und zur informationsübertragung an einen dritten teilnehmer |
US20080177154A1 (en) | 2001-08-13 | 2008-07-24 | Novo Nordisk A/S | Portable Device and Method Of Communicating Medical Data Information |
ATE464083T1 (de) | 2001-09-06 | 2010-04-15 | Microdose Therapeutx Inc | Inhalator typ dpi |
US20080148193A1 (en) | 2001-09-13 | 2008-06-19 | John Moetteli | System and method of efficient web browsing |
US20030068361A1 (en) | 2001-10-09 | 2003-04-10 | Rimona Margalit | Liposome-encapsulated insulin formulations |
US6684880B2 (en) | 2001-12-04 | 2004-02-03 | Hewlett-Packard Development Company, L.P. | Applicator for dispensing bioactive compositions and methods for using the same |
WO2003051424A2 (en) | 2001-12-17 | 2003-06-26 | Mcfarland Joseph L Jr | Portable, handheld, pneumatic driven medicinal nebulizer |
CA2472644C (en) | 2002-01-07 | 2013-11-05 | Aerogen, Inc. | Devices and methods for nebulizing fluids for inhalation |
WO2003059424A1 (en) | 2002-01-15 | 2003-07-24 | Aerogen, Inc. | Methods and systems for operating an aerosol generator |
FR2835435B1 (fr) | 2002-02-01 | 2004-04-23 | Diffusion Tech Francaise Sarl | Dispositif de protection du circuit sonique d'un generateur d'aerosol therapeutique |
GB0222295D0 (en) | 2002-09-25 | 2002-10-30 | 3M Innovative Properties Co | Breath actuated medicament dispensing devices |
US20040100509A1 (en) | 2002-11-27 | 2004-05-27 | Microsoft Corporation | Web page partitioning, reformatting and navigation |
US7683029B2 (en) | 2003-05-07 | 2010-03-23 | Philip Morris Usa Inc. | Liquid aerosol formulations containing insulin and aerosol generating devices and methods for generating aerosolized insulin |
US7600512B2 (en) | 2003-07-14 | 2009-10-13 | Vortran Medical Technology 1, Inc. | Inhaler with breath actuated dose counter |
US8616195B2 (en) | 2003-07-18 | 2013-12-31 | Novartis Ag | Nebuliser for the production of aerosolized medication |
US20050030953A1 (en) | 2003-08-04 | 2005-02-10 | Subramanian Vasudevan | Method of controlling reverse link transmission |
US20050172958A1 (en) | 2003-08-20 | 2005-08-11 | The Brigham And Women's Hospital, Inc. | Inhalation device and system for the remote monitoring of drug administration |
EP1694392A4 (de) | 2003-11-25 | 2008-05-14 | Robert E Coifman | Verfahren zur messung des einatemflusses |
WO2005065756A2 (en) | 2003-12-30 | 2005-07-21 | Oriel Therapeutics, Inc. | Dry powder nebulizers and associated methods of dispensing dry powders |
US7380550B2 (en) | 2004-01-30 | 2008-06-03 | Hewlett-Packard Development Company, L.P. | Systems and methods for particle detection |
US7819115B2 (en) | 2004-01-30 | 2010-10-26 | Hewlett-Packard Development Company, L.P. | Inhalers and methods of controlling airflow in inhalers |
US7712466B2 (en) * | 2004-02-20 | 2010-05-11 | Pneumoflex Systems, Llc | Intra-oral nebulizer |
EP2258428B1 (de) | 2004-04-02 | 2019-11-27 | The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services | Aerosolabgabesysteme |
GB0408836D0 (en) | 2004-04-21 | 2004-05-26 | Univ Hull | A system |
CA2626248A1 (en) | 2004-10-22 | 2006-04-27 | Multi-Vet Ltd. | Mobile electronic device with fluid delivery system |
WO2006062449A1 (en) | 2004-12-10 | 2006-06-15 | Ernst Hörlins Ingenjörsbyra AB | Breath actuated dose inhaler |
FR2879574B1 (fr) * | 2004-12-17 | 2011-01-21 | Valois Sas | Dispositif de distribution de produit fluide. |
US20080233053A1 (en) | 2005-02-07 | 2008-09-25 | Pharmalight Inc. | Method and Device for Ophthalmic Administration of Active Pharmaceutical Ingredients |
US7219664B2 (en) | 2005-04-28 | 2007-05-22 | Kos Life Sciences, Inc. | Breath actuated inhaler |
US20070074722A1 (en) | 2005-09-21 | 2007-04-05 | Kurve Technology, Inc. | Medicament delivery control, monitoring, and reporting system and method |
FR2892158B1 (fr) * | 2005-10-17 | 2011-10-21 | Valois Sas | Pompe de distribution de produit fluide |
ATE471144T1 (de) | 2005-10-20 | 2010-07-15 | Mdrna Inc | Intranasale verabreichung von schnell wirkendem insulin |
DE102005052898A1 (de) * | 2005-11-03 | 2007-05-10 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren und Vorrichtung zum Dosieren von Arzneimitteln |
AU2006318620B2 (en) * | 2005-11-21 | 2012-04-05 | Mannkind Corporation | Powder dispensing and sensing apparatus and methods |
DE102005056488A1 (de) | 2005-11-21 | 2007-05-24 | Ing. Erich Pfeiffer Gmbh | Spender und Dosierbaugruppe für die Mediumdosierung |
JP2009530243A (ja) | 2006-03-13 | 2009-08-27 | ノボ・ノルデイスク・エー/エス | アシル化単鎖インスリン |
WO2007116953A1 (en) | 2006-04-10 | 2007-10-18 | Canon Kabushiki Kaisha | Ingesta administration device |
DE102006026786A1 (de) | 2006-06-07 | 2007-12-13 | Joachim Kern | Dosierinhalator |
US9208500B2 (en) | 2006-07-21 | 2015-12-08 | Microsoft Technology Licensing, Llc | Fixed position multi-state interactive advertisement |
JP5207679B2 (ja) | 2006-08-01 | 2013-06-12 | キヤノン株式会社 | 薬剤吐出装置 |
CN101495168A (zh) | 2006-08-01 | 2009-07-29 | 佳能株式会社 | 药物喷射设备 |
US20100180890A1 (en) | 2006-09-29 | 2010-07-22 | Canon Kabushiki Kaisha | Inhaler |
US20080306794A1 (en) | 2006-11-27 | 2008-12-11 | Ooggieya Ltd. | Measurement of content placement effectiveness over web pages and like media |
US8342172B2 (en) | 2007-02-05 | 2013-01-01 | The Brigham And Women's Hospital, Inc. | Instrumented metered-dose inhaler and methods for predicting disease exacerbations |
US20090301472A1 (en) * | 2007-02-08 | 2009-12-10 | Kim Matthew H J | Aerosol delivery systems and methods |
US8348107B2 (en) * | 2007-02-20 | 2013-01-08 | Conagra Foods Rdm, Inc. | Food dispensing apparatus |
US7904062B2 (en) | 2007-03-08 | 2011-03-08 | Yahoo! Inc. | Scrolling mobile advertisements |
US20090241948A1 (en) | 2007-03-28 | 2009-10-01 | Dermot Joseph Clancy | Humidification in breathing circuits |
CA2963423C (en) | 2007-03-30 | 2020-07-28 | Philip Morris Products S.A. | Device and method for delivery of a medicament |
US8261738B2 (en) | 2007-07-24 | 2012-09-11 | Respironics Respiratory Drug Delivery (Uk) Ltd. | Apparatus and method for maintaining consistency for aerosol drug delivery treatments |
US20090151716A1 (en) | 2007-09-18 | 2009-06-18 | Robert Abrams | Semi-automatic emergency medication dose nebulizer |
US8486043B2 (en) | 2007-10-12 | 2013-07-16 | Map Pharmaceuticals, Inc. | Inhalation drug delivery |
US20090151718A1 (en) | 2007-12-13 | 2009-06-18 | Next Safety, Inc. | Apparatuses and Methods for Diagnosing and Treating Respiratory Conditions |
US20090156952A1 (en) | 2007-12-13 | 2009-06-18 | Hunter C Eric | Apparatuses and Methods for Diagnosing and Treating Respiratory Conditions |
US9550031B2 (en) | 2008-02-01 | 2017-01-24 | Reciprocal Labs Corporation | Device and method to monitor, track, map, and analyze usage of metered-dose inhalers in real-time |
WO2009111612A1 (en) | 2008-03-07 | 2009-09-11 | Novartis Ag | Aerosolization device |
JP2009268665A (ja) | 2008-05-07 | 2009-11-19 | Canon Inc | 吸入装置 |
ES2423587T3 (es) | 2008-07-10 | 2013-09-23 | Bang & Olufsen Medicom A/S | Inhalador y procedimiento de operación del mismo |
DE102008054431B3 (de) | 2008-12-09 | 2010-06-17 | Pari Pharma Gmbh | Aerosoltherapievorrichtung |
US8356247B2 (en) | 2008-12-16 | 2013-01-15 | Rich Media Worldwide, Llc | Content rendering control system and method |
JP5180109B2 (ja) | 2009-01-26 | 2013-04-10 | 株式会社エヌ・ティ・ティ・ドコモ | 移動通信方法及び無線基地局 |
US8736227B2 (en) | 2009-02-27 | 2014-05-27 | Fairchild Semiconductor Corporation | Peripheral device host charging |
NZ575836A (en) | 2009-03-27 | 2009-08-28 | Nexus6 Ltd | Improvements in or Relating to Medicament Delivery Systems |
CA2762590C (en) | 2009-06-04 | 2020-06-30 | The General Hospital Corporation | An airway organ bioreactor apparatus comprising a wet ventilator system and a dry ventilator system and an ex vivo method of providing a bioartificial lung matrix airway organ |
US8495998B2 (en) | 2009-06-17 | 2013-07-30 | British American Tobacco (Investments) Limited | Inhaler |
US9395827B2 (en) | 2009-07-21 | 2016-07-19 | Qualcomm Incorporated | System for detecting orientation of magnetically coupled devices |
US9545488B2 (en) * | 2010-01-12 | 2017-01-17 | Dance Biopharm Inc. | Preservative-free single dose inhaler systems |
US20130269684A1 (en) | 2012-04-16 | 2013-10-17 | Dance Pharmaceuticals, Inc. | Methods and systems for supplying aerosolization devices with liquid medicaments |
EP2525854A1 (de) | 2010-01-20 | 2012-11-28 | Koninklijke Philips Electronics N.V. | Verfahren zur verwendung eines aerosoldetektors auf temperaturbasis |
US20110225008A1 (en) | 2010-03-09 | 2011-09-15 | Respira Dv, Llc | Self-Similar Medical Communications System |
EP2545466A2 (de) | 2010-03-12 | 2013-01-16 | AOL Inc. | Systeme und verfahren zur organisation und anzeige von elektronischen medieninhalten |
US20130172690A1 (en) | 2010-04-11 | 2013-07-04 | Proteus Digital Health, Inc. | Apparatus, system and method for detection and delivery of a medicinal dose |
WO2011130583A2 (en) | 2010-04-15 | 2011-10-20 | Spectrum Health Innovations, LLC | Inhaler module and related system |
KR20120013727A (ko) | 2010-08-06 | 2012-02-15 | 삼성전자주식회사 | 디스플레이장치 및 그 제어방법 |
WO2012022026A1 (zh) | 2010-08-17 | 2012-02-23 | 富士通株式会社 | 一种资源分配方法、系统和发射机 |
WO2012048320A2 (en) | 2010-10-08 | 2012-04-12 | Myspace, Inc. | Hd website skin |
TW201219010A (en) | 2010-11-05 | 2012-05-16 | Univ Nat Cheng Kung | Portable asthma detection device and stand-alone portable asthma detection device |
JP5487093B2 (ja) | 2010-12-17 | 2014-05-07 | 三菱航空機株式会社 | 耐雷ファスナ、耐雷ファスナの取付構造、航空機 |
WO2013009346A1 (en) | 2011-07-12 | 2013-01-17 | Intel Corporation | Resource scheduling for machine-to-machine devices |
US8326964B1 (en) | 2011-11-14 | 2012-12-04 | Limelight Networks, Inc. | Website data content access progression |
GB2498569A (en) | 2012-01-20 | 2013-07-24 | Intellectual Ventures Holding 81 Llc | Terminal device communicating on a narrow subset frequency contained within a main frequency band |
US20130269694A1 (en) | 2012-04-16 | 2013-10-17 | Dance Pharmaceuticals, Inc. | Inhaler controlled by mobile device |
EP2667292A3 (de) | 2012-05-24 | 2015-12-30 | BlackBerry Limited | Darstellung eines Bildes auf einem Anzeigebildschirm mit kombiniertem Zuschneiden und Rotieren sowie mit automatischer Skalierung des Zuschnittfelds |
US9248246B2 (en) | 2013-09-27 | 2016-02-02 | Cellco Partnership | Category 1 M2M device data transmission via a long term evolution network |
-
2013
- 2013-03-14 US US13/830,511 patent/US20130269684A1/en not_active Abandoned
- 2013-03-28 CN CN201380031665.2A patent/CN104470567B/zh active Active
- 2013-03-28 EP EP13778248.8A patent/EP2838592B1/de active Active
- 2013-03-28 WO PCT/US2013/034359 patent/WO2013158353A1/en active Application Filing
- 2013-03-28 BR BR112014025878A patent/BR112014025878B8/pt active IP Right Grant
- 2013-03-28 RU RU2014145836A patent/RU2637285C2/ru not_active IP Right Cessation
-
2018
- 2018-09-17 US US16/133,484 patent/US11786676B2/en active Active
Patent Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1947310A (en) * | 1933-04-07 | 1934-02-13 | Warren M Sample | Liquid dispenser |
US3874380A (en) * | 1974-05-28 | 1975-04-01 | Smithkline Corp | Dual nozzle intranasal delivery device |
US5487378A (en) * | 1990-12-17 | 1996-01-30 | Minnesota Mining And Manufacturing Company | Inhaler |
US5385180A (en) * | 1994-06-09 | 1995-01-31 | Empak, Inc. | Liquid saver funnel system |
WO1998022290A1 (en) * | 1996-11-18 | 1998-05-28 | Pbt International Ltd. | An inkjet cartridge refill device |
US6257454B1 (en) * | 1998-05-02 | 2001-07-10 | Ing. Erich Pfeiffer Gmbh | Media dispenser |
US6748946B1 (en) * | 1998-09-26 | 2004-06-15 | Smithkline Beecham Corporation | Inhalation device |
US7600511B2 (en) * | 2001-11-01 | 2009-10-13 | Novartis Pharma Ag | Apparatus and methods for delivery of medicament to a respiratory system |
US20040154617A1 (en) * | 2002-09-27 | 2004-08-12 | Dietmar Enk | Fiberoptic nebulizer |
US7886783B2 (en) * | 2009-05-22 | 2011-02-15 | The General Electric Company | Anesthetic vaporizer filling system |
US20110168172A1 (en) * | 2010-01-12 | 2011-07-14 | Dance Pharmaceuticals, Inc. | Preservative-free single dose inhaler systems |
Cited By (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10744282B2 (en) | 2010-01-12 | 2020-08-18 | Aerami Therapeutics, Inc. | Preservative free insulin formulations |
US11833291B2 (en) | 2010-01-12 | 2023-12-05 | Aerami Therapeutics, Inc. | Preservative-free single dose inhaler systems |
US10076613B2 (en) | 2010-01-12 | 2018-09-18 | Dance Biopharm Inc. | Preservative free insulin formulations |
US10842951B2 (en) | 2010-01-12 | 2020-11-24 | Aerami Therapeutics, Inc. | Liquid insulin formulations and methods relating thereto |
US11426536B2 (en) | 2014-06-09 | 2022-08-30 | Aerami Therapeutics, Inc. | Liquid drug cartridges and associated dispenser |
US10307550B2 (en) | 2014-06-09 | 2019-06-04 | Dance Biopharm Inc. | Liquid drug cartridges and associated dispenser |
US10610651B2 (en) | 2014-06-09 | 2020-04-07 | Aerami Therapeutics, Inc. | Self-puncturing liquid drug cartridges and associated dispenser |
US11285275B2 (en) | 2014-06-09 | 2022-03-29 | Aerami Therapeutics, Inc. | Self-puncturing liquid drug cartridges and associated dispenser |
US11273271B2 (en) | 2014-07-01 | 2022-03-15 | Aerami Therapeutics, Inc. | Aerosolization system with flow restrictor and feedback device |
US10471222B2 (en) | 2014-07-01 | 2019-11-12 | Dance Biopharm Inc. | Aerosolization system with flow restrictor and feedback device |
US10857313B2 (en) | 2014-07-01 | 2020-12-08 | Aerami Therapeutics, Inc. | Liquid nebulization systems and methods |
US11096990B2 (en) | 2015-02-25 | 2021-08-24 | Aerami Therapeutics, Inc. | Liquid insulin formulations and methods relating thereto |
US11504489B2 (en) | 2015-07-17 | 2022-11-22 | Rai Strategic Holdings, Inc. | Contained liquid system for refilling aerosol delivery devices |
EP3733234A1 (de) * | 2015-07-17 | 2020-11-04 | RAI Strategic Holdings, Inc. | Eingedämmtes flüssigkeitssystem zum nachfüllen von aerosolabgabevorrichtungen |
WO2017015017A1 (en) * | 2015-07-17 | 2017-01-26 | R. J. Reynolds Tobacco Company | Contained liquid system for refilling aerosol delivery devices |
RU2702242C2 (ru) * | 2015-07-17 | 2019-10-07 | Раи Стретеджик Холдингс, Инк. | Содержащая жидкость система для повторной заправки устройств доставки аэрозоля |
US10783771B2 (en) * | 2015-10-06 | 2020-09-22 | Thorn Security Limited | Smoke detector tester |
US20180293878A1 (en) * | 2015-10-06 | 2018-10-11 | Thorn Security Limited | Smoke detector tester |
US11412781B2 (en) * | 2016-02-12 | 2022-08-16 | Rai Strategic Holdings, Inc. | Adapters for refilling an aerosol delivery device |
EP4285746A3 (de) * | 2016-02-12 | 2024-03-06 | RAI Strategic Holdings, Inc. | Adapter zur wiederbefüllung einer aerosolfreisetzungsvorrichtung |
WO2017137928A1 (en) * | 2016-02-12 | 2017-08-17 | Rai Strategic Holdings, Inc. | Adapters for refilling an aerosol delivery device |
EP3413729B1 (de) * | 2016-02-12 | 2023-11-01 | RAI Strategic Holdings, Inc. | Adapter zur wiederbefüllung einer aerosolfreisetzungsvorrichtung |
CN108697155A (zh) * | 2016-02-12 | 2018-10-23 | 莱战略控股公司 | 用于再充填气溶胶释放装置的适配器 |
RU2733562C2 (ru) * | 2016-02-12 | 2020-10-05 | Раи Стретеджик Холдингс, Инк. | Переходники для повторного заполнения устройства для доставки аэрозоля |
US11291779B2 (en) * | 2016-07-15 | 2022-04-05 | Koninklijke Philips N.V. | Aerosolization device and an aerosol drug delivery device |
US11771852B2 (en) * | 2017-11-08 | 2023-10-03 | Pneuma Respiratory, Inc. | Electronic breath actuated in-line droplet delivery device with small volume ampoule and methods of use |
US20200353186A1 (en) * | 2017-11-08 | 2020-11-12 | Pneuma Respiratory, Inc. | Electronic breath actuated in-line droplet delivery device with small volume ampoule and methods of use |
US20210106772A1 (en) * | 2018-04-02 | 2021-04-15 | Pneuma Respiratory, Inc. | Handheld digital nebulizer device and methods of use |
WO2019239217A1 (en) * | 2018-06-14 | 2019-12-19 | Nexvap Sa | Electromechanical apparatus and method for using a mobile inhaler |
US11690963B2 (en) | 2018-08-22 | 2023-07-04 | Qnovia, Inc. | Electronic device for producing an aerosol for inhalation by a person |
US10888117B2 (en) | 2018-10-18 | 2021-01-12 | Respira Technologies, Inc. | Apparatus for producing an aerosol for inhalation by a person |
US11517685B2 (en) | 2019-01-18 | 2022-12-06 | Qnovia, Inc. | Electronic device for producing an aerosol for inhalation by a person |
WO2021003277A1 (en) | 2019-07-03 | 2021-01-07 | Aerami Therapeutics, Inc. | Exenatide compositions for pulmonary administration and use thereof |
US11246338B2 (en) * | 2019-09-26 | 2022-02-15 | Dmitry Yankelevich | Device for smoking tobacco and other inhalation materials |
US20210228824A1 (en) * | 2020-01-29 | 2021-07-29 | Aerami Therapeutics, Inc. | Wicking cap and methods |
US11998686B2 (en) | 2022-10-10 | 2024-06-04 | Rai Strategic Holdings, Inc. | Contained liquid system for refilling aerosol delivery devices |
Also Published As
Publication number | Publication date |
---|---|
BR112014025878B8 (pt) | 2022-07-19 |
RU2014145836A (ru) | 2016-06-10 |
CN104470567B (zh) | 2018-11-02 |
BR112014025878A2 (de) | 2017-06-20 |
EP2838592A4 (de) | 2015-11-25 |
US11786676B2 (en) | 2023-10-17 |
RU2637285C2 (ru) | 2017-12-01 |
EP2838592A1 (de) | 2015-02-25 |
EP2838592B1 (de) | 2018-05-30 |
CN104470567A (zh) | 2015-03-25 |
WO2013158353A1 (en) | 2013-10-24 |
US20190015611A1 (en) | 2019-01-17 |
BR112014025878B1 (pt) | 2022-04-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US11786676B2 (en) | Methods and systems for supplying aerosolization devices with liquid medicaments | |
US11833291B2 (en) | Preservative-free single dose inhaler systems | |
US11285275B2 (en) | Self-puncturing liquid drug cartridges and associated dispenser | |
EP2714280B1 (de) | Zerstäuber | |
CN105307620B (zh) | 液体分配和用于分配液体的方法 | |
US9545488B2 (en) | Preservative-free single dose inhaler systems | |
EP2986268B1 (de) | Flüssigkeitsabgabe |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: DANCE PHARMACEUTICALS INC., CALIFORNIA Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:PATTON, RYAN S.;REEL/FRAME:030940/0391 Effective date: 20130803 |
|
AS | Assignment |
Owner name: DANCE BIOPHARM INC., CALIFORNIA Free format text: CHANGE OF NAME;ASSIGNOR:DANCE PHARMACEUTICALS, INC.;REEL/FRAME:033085/0617 Effective date: 20130219 |
|
AS | Assignment |
Owner name: HERCULES TECHNOLOGY III, L.P., CALIFORNIA Free format text: SECURITY INTEREST;ASSIGNORS:DANCE BIOPHARM, INC.;DANCE BIOPHARM HOLDINGS, INC.;REEL/FRAME:039603/0582 Effective date: 20160601 |
|
AS | Assignment |
Owner name: GPB DEBT HOLDINGS II, LLC, AS AGENT FOR THE FOLLOWING:, NEW YORK Free format text: SECURITY INTEREST;ASSIGNORS:DANCE BIOPHARM HOLDINGS, INC.;DANCE BIOPHARM, INC.;REEL/FRAME:040215/0239 Effective date: 20161020 Owner name: DANCE BIOPHARM INC., CALIFORNIA Free format text: RELEASE BY SECURED PARTY;ASSIGNOR:HERCULES TECHNOLOGY III, LP;REEL/FRAME:040215/0128 Effective date: 20161020 Owner name: DOMINION CAPITAL LLC, NEW YORK Free format text: SECURITY INTEREST;ASSIGNORS:DANCE BIOPHARM HOLDINGS, INC.;DANCE BIOPHARM, INC.;REEL/FRAME:040215/0239 Effective date: 20161020 Owner name: GPB DEBT HOLDINGS II, LLC, AS AGENT FOR THE FOLLOW Free format text: SECURITY INTEREST;ASSIGNORS:DANCE BIOPHARM HOLDINGS, INC.;DANCE BIOPHARM, INC.;REEL/FRAME:040215/0239 Effective date: 20161020 Owner name: DANCE BIOPHARM HOLDINGS, INC., CALIFORNIA Free format text: RELEASE BY SECURED PARTY;ASSIGNOR:HERCULES TECHNOLOGY III, LP;REEL/FRAME:040215/0128 Effective date: 20161020 |
|
AS | Assignment |
Owner name: DANCE BIOPHARM INC., CALIFORNIA Free format text: NUNC PRO TUNC ASSIGNMENT;ASSIGNOR:PATTON, RYAN S.;REEL/FRAME:044232/0636 Effective date: 20171123 |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |