US3874380A - Dual nozzle intranasal delivery device - Google Patents
Dual nozzle intranasal delivery device Download PDFInfo
- Publication number
- US3874380A US3874380A US473372A US47337274A US3874380A US 3874380 A US3874380 A US 3874380A US 473372 A US473372 A US 473372A US 47337274 A US47337274 A US 47337274A US 3874380 A US3874380 A US 3874380A
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- US
- United States
- Prior art keywords
- opening
- cavity
- container
- reception
- nozzle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
- A61M11/007—Syringe-type or piston-type sprayers or atomisers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0033—Details of the piercing or cutting means
- A61M15/0035—Piercing means
- A61M15/0036—Piercing means hollow piercing means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/08—Inhaling devices inserted into the nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/06—Respiratory or anaesthetic masks
- A61M16/0666—Nasal cannulas or tubing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0468—Liquids non-physiological
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/07—General characteristics of the apparatus having air pumping means
- A61M2205/071—General characteristics of the apparatus having air pumping means hand operated
- A61M2205/073—Syringe, piston type
Definitions
- a dual nozzle intranasal delivery device has a housing having a cavity for the reception of a container, an opening for the reception of a syringe nozzle, and a passage connecting said cavity and said opening.
- a hollow needle is secured in the passage and extends into the cavity, said needle being adapted to penetrate the stopper of the container.
- a pair of adjacent spray nozzles having substantially parallel axes are in communication with a conduit in the housing which has an opening for the reception of a syringe nozzle.
- DUAL NOZZLE INTRANASAL DELIVERY DEVICE BACKGROUND OF THE INVENTION It is known to employ a pair of adjacent spray nozzles communicating with a conduit which is adapted to be connected to a syringe to deliver vaccine such as a flu vaccine or a measles vaccine in about equal doses to each nostril. While this operation is simple and effective, it still leaves the patient with a difficult problem in getting the dosage in liquid form in the syringe. This is particularly the case where the biological to be employed is lyophilized.
- a lyophilized medicament can be placed in solution in a syringe under sterile conditions with great ease by an unskilled patient.
- a dual nozzle intranasal delivery device has a housing having a cavity for the reception of a container, an opening for the reception ofa syringe nozzle, and a passage connecting said cavity and said opening.
- a hollow needle is secured in the passage and extends into the cavity, said needle being adapted to penetrate the stopper of the container.
- a pair of adjacent spray nozzles having substantially parallel axes are in communication with a conduit in the housing which has an opening for the reception of a syringe nozzle.
- FIG. 1 is an exploded view of an intranasal delivery device in accordance with the invention together with a container and a syringe;
- FIG. 2 is a section through the intranasal device of FIG. 1;
- FIG. 3 is a view of the intranasal device of FIG. 1 taken on the plane indicated by the line 3-3 in FIG. 2;
- FIG. 4 is an elevational view of the intranasal device of FIG. 1 shown together with a syringe.
- An intranasal device 2 has a housing 4 provided with a cylindrical cavity 6 adapted to receive a container 8 typically containing a tablet 10 of a lyophilized biological.
- Container 10 is of a type well known to the art and has a pierceable rubber stopper 14 which is held in position by a metal cap 16. Any of the wide variety of containers currently employed with syringes provided with a needle for piercing a container stopper may be employed.
- Housing 4 has a passage 18 in which a hollow needle 20 is secured by a pressed fit. Needle 20 extends into 40 is in communication with a. conduit 44 which has a pair of branches 46 and 48.
- a pair of spray nozzles 52 and 54 are substantially parallel and spaced apart a distance to permit one spray nozzle to enter each nostril.
- Each of the spray nozzles has a cap 56 having a discharge passage 58, the passages 58, 58 being substantially parallel.
- Each cap 56 has an interior opening 60 which is adapted to receive branches 46 and 48 respectively and a bead 62 adapted to snap into grooves 64 and 66 respectively in branches 46 and 48.
- Branch 46 has a side opening 70 which discharges into cavity 72 in the cap 56 mounted on branch 46.
- branch 48 has a side discharge opening 74 which discharges into cavity 76 of the cap 56 mounted on branch 48.
- the spray nozzles per se are conventional and any spray nozzles conventionally used for spraying liquids into the nose may be employed.
- container 8 is inserted into cavity 6 and thrust home causing needle 20 to pierce the pierceable rubber stopper l4 and extend into the interior of container 8.
- nozzle 28 pointing upwardly, cover 32 is removed from nozzle 28 of syringe 30 which contains a suitable reconstituting liquid and the nozzle 28 is inserted into opening 26.
- Plunger 34 is then advanced to force the reconstituting liquid from syringe 30 into container 8.
- plunger 34 is retracted to draw the thus formed solution into the syringe 30.
- the syringe 30 is now withdrawn from opening 26 and its nozzle is inserted into opening 40. With the spray nozzles 52 and 54 inserted into the patients nostrils, plunger 34 is depressed so as to force the contained liquid into conduit 44 and equally through branches 46 and 48 and through spray nozzles 52 and 54.
- a dual nozzle intranasal delivery device comprising:
- said housing having a cavity for the reception of a container having a pierceable stopper
- said housing having a conduit communicating with said nozzles and having a second opening for the reception of a syringe nozzle, and a second passage connecting said second opening with said nozzles, whereby liquid can be introduced into and withdrawn from a container and then discharged through the nozzles.
Abstract
A dual nozzle intranasal delivery device has a housing having a cavity for the reception of a container, an opening for the reception of a syringe nozzle, and a passage connecting said cavity and said opening. A hollow needle is secured in the passage and extends into the cavity, said needle being adapted to penetrate the stopper of the container. A pair of adjacent spray nozzles having substantially parallel axes are in communication with a conduit in the housing which has an opening for the reception of a syringe nozzle.
Description
United States Patent Inventor: Ronald Baum, Merion, Pa.
Smithkline Corporation, Philadelphia, Pa.
Filed: May 28, 1974 Appl. No.: 473,372
Assignee:
References Cited UNITED STATES PATENTS 9/1902 Gundlach et a1. 128/235 Baum Apr. 1, 1975 [54] DUAL NOZZLE INTRANASAL DELIVERY 1,930,929 10/1933 Eisenberg .Q. 128/235 DEVICE 3,330,277 7/1967 Gabriels 128/218 R Primary E.\'aminer Richard A. Gaudet Assistant Examiner-Henry J, Recla Attorney, Agent, or Firm -Smith, Harding, Earley & Follmer [5 7] AB STRA CT A dual nozzle intranasal delivery device has a housing having a cavity for the reception of a container, an opening for the reception of a syringe nozzle, and a passage connecting said cavity and said opening. A hollow needle is secured in the passage and extends into the cavity, said needle being adapted to penetrate the stopper of the container. A pair of adjacent spray nozzles having substantially parallel axes are in communication with a conduit in the housing which has an opening for the reception of a syringe nozzle.
1 Claim, 4 Drawing Figures Z ATENTED APR 1 FIG.4.
DUAL NOZZLE INTRANASAL DELIVERY DEVICE BACKGROUND OF THE INVENTION It is known to employ a pair of adjacent spray nozzles communicating with a conduit which is adapted to be connected to a syringe to deliver vaccine such as a flu vaccine or a measles vaccine in about equal doses to each nostril. While this operation is simple and effective, it still leaves the patient with a difficult problem in getting the dosage in liquid form in the syringe. This is particularly the case where the biological to be employed is lyophilized. In accordance with this invention a lyophilized medicament can be placed in solution in a syringe under sterile conditions with great ease by an unskilled patient.
BRIEF SUMMARY OF THE INVENTION A dual nozzle intranasal delivery device has a housing having a cavity for the reception of a container, an opening for the reception ofa syringe nozzle, and a passage connecting said cavity and said opening. A hollow needle is secured in the passage and extends into the cavity, said needle being adapted to penetrate the stopper of the container. A pair of adjacent spray nozzles having substantially parallel axes are in communication with a conduit in the housing which has an opening for the reception of a syringe nozzle.
BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is an exploded view of an intranasal delivery device in accordance with the invention together with a container and a syringe;
FIG. 2 is a section through the intranasal device of FIG. 1;
FIG. 3 is a view of the intranasal device of FIG. 1 taken on the plane indicated by the line 3-3 in FIG. 2; and
FIG. 4 is an elevational view of the intranasal device of FIG. 1 shown together with a syringe.
DETAILED DESCRIPTION An intranasal device 2 has a housing 4 provided with a cylindrical cavity 6 adapted to receive a container 8 typically containing a tablet 10 of a lyophilized biological. Container 10 is of a type well known to the art and has a pierceable rubber stopper 14 which is held in position by a metal cap 16. Any of the wide variety of containers currently employed with syringes provided with a needle for piercing a container stopper may be employed.
OPERATION Assuming that a lyophilized biological such as the tablet 10 is to be administered, container 8 is inserted into cavity 6 and thrust home causing needle 20 to pierce the pierceable rubber stopper l4 and extend into the interior of container 8.. With nozzle 28 pointing upwardly, cover 32 is removed from nozzle 28 of syringe 30 which contains a suitable reconstituting liquid and the nozzle 28 is inserted into opening 26. Plunger 34 is then advanced to force the reconstituting liquid from syringe 30 into container 8. When the biological tablet 10 has dissolved in the reconstituting liquid, plunger 34 is retracted to draw the thus formed solution into the syringe 30. The syringe 30 is now withdrawn from opening 26 and its nozzle is inserted into opening 40. With the spray nozzles 52 and 54 inserted into the patients nostrils, plunger 34 is depressed so as to force the contained liquid into conduit 44 and equally through branches 46 and 48 and through spray nozzles 52 and 54.
It will be understood that the foregoing description is illustrative and not limiting.
I claim:
1. A dual nozzle intranasal delivery device compris ing:
a housing,
said housing having a cavity for the reception of a container having a pierceable stopper,
an opening for the reception of a syringe nozzle and a passage connecting said cavity and said opening, a hollow needle secured in said passage by a pressed fit and extending into the cavity, said needle being adapted to penetrate the stopper of said container,
a pair of adjacent nozzles having substantially parallel axes,
said housing having a conduit communicating with said nozzles and having a second opening for the reception of a syringe nozzle, and a second passage connecting said second opening with said nozzles, whereby liquid can be introduced into and withdrawn from a container and then discharged through the nozzles.
Claims (1)
1. A dual nozzle intranasal delivery device comprising: a housing, said housing having a cavity for the reception of a container having a pierceable stopper, an opening for the reception of a syringe nozzle and a passage connecting said cavity and said opening, a hollow needle secured in said passage by a pressed fit and extending into the cavity, said needle being adapted to penetrate the stopper of said container, a pair of adjacent nozzles having substantially parallel axes, said housing having a conduit communicating with said nozzles and having a second opening for the reception of a syringe nozzle, and a second passage connecting said second opening with said nozzles, whereby liquid can be introduced into and withdrawn from a container and then discharged through the nozzles.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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US473372A US3874380A (en) | 1974-05-28 | 1974-05-28 | Dual nozzle intranasal delivery device |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US473372A US3874380A (en) | 1974-05-28 | 1974-05-28 | Dual nozzle intranasal delivery device |
Publications (1)
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US3874380A true US3874380A (en) | 1975-04-01 |
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Family Applications (1)
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US473372A Expired - Lifetime US3874380A (en) | 1974-05-28 | 1974-05-28 | Dual nozzle intranasal delivery device |
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Cited By (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3933155A (en) * | 1975-01-23 | 1976-01-20 | Mizzy Inc. | Pressure injector apparatus having improved trigger mechanism |
US4475915A (en) * | 1982-05-07 | 1984-10-09 | Sloane Glenn L | Holder for a syringe and an ampoule |
US5026357A (en) * | 1986-09-22 | 1991-06-25 | Schering Ag | Injection device |
US5240047A (en) * | 1992-05-06 | 1993-08-31 | Hedges Harry S | Syringe guide and bottle holder |
US5433191A (en) * | 1992-05-15 | 1995-07-18 | Habley Medical Technology Corp. | Medication sprayer |
US5505236A (en) * | 1994-04-04 | 1996-04-09 | Abbott Laboratories | Anesthetic vaporizer filling system |
US5601077A (en) * | 1991-08-07 | 1997-02-11 | Becton, Dickinson And Company | Nasal syringe sprayer with removable dose limiting structure |
WO1997039831A1 (en) * | 1996-04-19 | 1997-10-30 | Boehringer Ingelheim Pharma Kg | Two-chamber cartridge for propellant-free metered aerosols |
US5894870A (en) * | 1997-06-10 | 1999-04-20 | Pharmacia & Upjohn Company | Syringe guide and vial holder |
US5899202A (en) * | 1995-06-30 | 1999-05-04 | Unisia Jecs Corporation | Medicine administering device for nasal cavities and method of using same |
FR2771012A1 (en) * | 1997-11-17 | 1999-05-21 | Sofab | Nasal spray which allows both nostrils to be treated at the same time |
US5961489A (en) * | 1997-10-08 | 1999-10-05 | Shinko Kagaku Kabushiki Kaisha | Spray adaptors for spraying collunarium and sprayers employing the spray adaptors |
US6382204B1 (en) | 1999-10-14 | 2002-05-07 | Becton Dickinson And Company | Drug delivery system including holder and drug container |
US6431172B1 (en) * | 2000-10-20 | 2002-08-13 | Mallinckrodt Inc. | Nasal cannula with inflatable plenum chamber |
WO2002074375A1 (en) * | 2001-03-20 | 2002-09-26 | Aradigm Corporation | Aerosol generation using sterile multiple dose containers |
US20030047184A1 (en) * | 2001-01-12 | 2003-03-13 | Lockhart Artis R. | Medicament respiratory delivery device |
US6585016B1 (en) | 2002-03-15 | 2003-07-01 | Datex-Ohmeda, Inc. | Keyed anesthetic vaporizer filling system |
US6718969B1 (en) * | 2002-05-28 | 2004-04-13 | Darren Rubin | Medication dosage inhaler system |
US20040134562A1 (en) * | 2003-01-14 | 2004-07-15 | Engel Steven P. | Connector device for sealing and dispensing freeze-dried preparations |
WO2005046773A1 (en) * | 2003-11-10 | 2005-05-26 | Mb Innovation | Disposable medicated-fluid-spray device |
US7296566B2 (en) | 1999-10-14 | 2007-11-20 | Becton, Dickinson And Company | Nasal delivery device including spray nozzle |
US20110083665A1 (en) * | 2003-12-16 | 2011-04-14 | Wolfe Tory Medical, Inc. | Vial multi-access adapter |
US20130269684A1 (en) * | 2012-04-16 | 2013-10-17 | Dance Pharmaceuticals, Inc. | Methods and systems for supplying aerosolization devices with liquid medicaments |
US20140124087A1 (en) * | 2012-11-08 | 2014-05-08 | Nordson Corporation | Fluid delivery assemblies for withdrawing biomaterial fluid from a vial and for dispensing the biomaterial fluid, fluid control devices therefor, and related methods |
CN103785090A (en) * | 2003-12-31 | 2014-05-14 | 雷斯梅德有限公司 | Compact oronasal patient interface |
WO2015104511A1 (en) | 2014-01-13 | 2015-07-16 | Aptar France Sas | Method for using an assembly for dispensing a fluid product |
US20160279332A1 (en) * | 2013-11-01 | 2016-09-29 | Consort Medical Plc | Medicament delivery device sub-assembly |
US20170340869A1 (en) * | 2013-03-26 | 2017-11-30 | George Naoum | Device and Method of Controlled Provision of Therapeutic Liquid in the Nose |
US9883932B2 (en) | 2009-10-19 | 2018-02-06 | Aircom Manufacturing, Inc. | Transdermal dispensing apparatus and methods |
US20180064898A1 (en) * | 2015-03-31 | 2018-03-08 | Fisher & Paykel Healthcare Limited | Nasal cannula |
US10912914B2 (en) | 2019-06-06 | 2021-02-09 | GE Precision Healthcare LLC | Systems and methods for bottle retention |
US11400241B2 (en) | 2010-01-12 | 2022-08-02 | Aerami Therapeutics, Inc. | Preservative-free single dose inhaler systems |
EP4052746A4 (en) * | 2019-11-06 | 2023-11-22 | Nipro Corporation | Syringe-type ejection device |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US708224A (en) * | 1901-10-18 | 1902-09-02 | Frank C Gundlach | Syringe. |
US1930929A (en) * | 1931-05-12 | 1933-10-17 | Eisenberg Moses Joel | Hypodermic implement |
US3330277A (en) * | 1964-08-17 | 1967-07-11 | Scherer Corp R P | Multidose hypodermic injector |
-
1974
- 1974-05-28 US US473372A patent/US3874380A/en not_active Expired - Lifetime
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US708224A (en) * | 1901-10-18 | 1902-09-02 | Frank C Gundlach | Syringe. |
US1930929A (en) * | 1931-05-12 | 1933-10-17 | Eisenberg Moses Joel | Hypodermic implement |
US3330277A (en) * | 1964-08-17 | 1967-07-11 | Scherer Corp R P | Multidose hypodermic injector |
Cited By (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3933155A (en) * | 1975-01-23 | 1976-01-20 | Mizzy Inc. | Pressure injector apparatus having improved trigger mechanism |
US4475915A (en) * | 1982-05-07 | 1984-10-09 | Sloane Glenn L | Holder for a syringe and an ampoule |
US5026357A (en) * | 1986-09-22 | 1991-06-25 | Schering Ag | Injection device |
US5601077A (en) * | 1991-08-07 | 1997-02-11 | Becton, Dickinson And Company | Nasal syringe sprayer with removable dose limiting structure |
US5240047A (en) * | 1992-05-06 | 1993-08-31 | Hedges Harry S | Syringe guide and bottle holder |
US5433191A (en) * | 1992-05-15 | 1995-07-18 | Habley Medical Technology Corp. | Medication sprayer |
US5505236A (en) * | 1994-04-04 | 1996-04-09 | Abbott Laboratories | Anesthetic vaporizer filling system |
US5899202A (en) * | 1995-06-30 | 1999-05-04 | Unisia Jecs Corporation | Medicine administering device for nasal cavities and method of using same |
WO1997039831A1 (en) * | 1996-04-19 | 1997-10-30 | Boehringer Ingelheim Pharma Kg | Two-chamber cartridge for propellant-free metered aerosols |
US20050241634A1 (en) * | 1996-04-19 | 2005-11-03 | Dieter Hochrainer | Two-chamber cartridge for propellant-free metering aerosols |
US7213593B2 (en) | 1996-04-19 | 2007-05-08 | Boehringer Ingelheim Kg | Two-chamber cartridge for propellant-free metering aerosols |
US7793655B2 (en) | 1996-04-19 | 2010-09-14 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Two-chamber cartridge for propellant-free metering aerosols |
CN1090538C (en) * | 1996-04-19 | 2002-09-11 | 贝林格尔英格海姆法玛公司 | Two-chamber cartridge for propellant-free metered aerosols |
AU718754B2 (en) * | 1996-04-19 | 2000-04-20 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Two-chamber cartridge for propellant-free metered aerosols |
US7980243B2 (en) | 1996-04-19 | 2011-07-19 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | Two-chamber cartridge for propellant-free metering aerosols |
US5894870A (en) * | 1997-06-10 | 1999-04-20 | Pharmacia & Upjohn Company | Syringe guide and vial holder |
US5961489A (en) * | 1997-10-08 | 1999-10-05 | Shinko Kagaku Kabushiki Kaisha | Spray adaptors for spraying collunarium and sprayers employing the spray adaptors |
WO1999025408A1 (en) * | 1997-11-17 | 1999-05-27 | Rexam Sofab | Nose sprayer |
FR2771012A1 (en) * | 1997-11-17 | 1999-05-21 | Sofab | Nasal spray which allows both nostrils to be treated at the same time |
US6382204B1 (en) | 1999-10-14 | 2002-05-07 | Becton Dickinson And Company | Drug delivery system including holder and drug container |
US7296566B2 (en) | 1999-10-14 | 2007-11-20 | Becton, Dickinson And Company | Nasal delivery device including spray nozzle |
US6530371B2 (en) | 1999-10-14 | 2003-03-11 | Becton, Dickinson And Company | Drug delivery system including holder and drug container |
US6431172B1 (en) * | 2000-10-20 | 2002-08-13 | Mallinckrodt Inc. | Nasal cannula with inflatable plenum chamber |
US20030047184A1 (en) * | 2001-01-12 | 2003-03-13 | Lockhart Artis R. | Medicament respiratory delivery device |
US7270127B2 (en) * | 2001-01-12 | 2007-09-18 | Becton, Dickinson And Company | Medicament respiratory delivery device |
WO2002074375A1 (en) * | 2001-03-20 | 2002-09-26 | Aradigm Corporation | Aerosol generation using sterile multiple dose containers |
US6929041B2 (en) | 2002-03-15 | 2005-08-16 | Datex-Ohmeda, Inc. | Keyed anesthetic vaporizer filling system |
US6585016B1 (en) | 2002-03-15 | 2003-07-01 | Datex-Ohmeda, Inc. | Keyed anesthetic vaporizer filling system |
US6817390B2 (en) | 2002-03-15 | 2004-11-16 | Datex-Ohmeda, Inc. | Keyed anesthetic vaporizer filling system |
US20040206417A1 (en) * | 2002-03-15 | 2004-10-21 | Falligant John C. | Keyed anesthetic vaporizer filling system |
US20040089375A1 (en) * | 2002-03-15 | 2004-05-13 | Datex-Ohmeda, Inc. | Keyed anesthetic vaporizer filling system |
US6718969B1 (en) * | 2002-05-28 | 2004-04-13 | Darren Rubin | Medication dosage inhaler system |
US6779566B2 (en) * | 2003-01-14 | 2004-08-24 | Access Business Group International Llc | Connector device for sealing and dispensing freeze-dried preparations |
US20040134562A1 (en) * | 2003-01-14 | 2004-07-15 | Engel Steven P. | Connector device for sealing and dispensing freeze-dried preparations |
WO2005046773A1 (en) * | 2003-11-10 | 2005-05-26 | Mb Innovation | Disposable medicated-fluid-spray device |
US20110083665A1 (en) * | 2003-12-16 | 2011-04-14 | Wolfe Tory Medical, Inc. | Vial multi-access adapter |
US10806886B2 (en) | 2003-12-31 | 2020-10-20 | ResMed Pty Ltd | Compact oronasal patient interface |
CN103785090A (en) * | 2003-12-31 | 2014-05-14 | 雷斯梅德有限公司 | Compact oronasal patient interface |
US11229762B2 (en) | 2003-12-31 | 2022-01-25 | ResMed Pty Ltd | Compact oronasal patient interface |
US10646677B2 (en) | 2003-12-31 | 2020-05-12 | ResMed Pty Ltd | Compact oronasal patient interface |
US11633562B2 (en) | 2003-12-31 | 2023-04-25 | ResMed Pty Ltd | Compact oronasal patient interface |
US10569042B2 (en) | 2003-12-31 | 2020-02-25 | ResMed Pty Ltd | Compact oronasal patient interface |
US11077275B2 (en) | 2003-12-31 | 2021-08-03 | ResMed Pty Ltd | Compact oronasal patient interface |
US9883932B2 (en) | 2009-10-19 | 2018-02-06 | Aircom Manufacturing, Inc. | Transdermal dispensing apparatus and methods |
US11400241B2 (en) | 2010-01-12 | 2022-08-02 | Aerami Therapeutics, Inc. | Preservative-free single dose inhaler systems |
US11786676B2 (en) | 2010-01-12 | 2023-10-17 | Aerami Therapeutics, Inc. | Methods and systems for supplying aerosolization devices with liquid medicaments |
US11833291B2 (en) | 2010-01-12 | 2023-12-05 | Aerami Therapeutics, Inc. | Preservative-free single dose inhaler systems |
US20130269684A1 (en) * | 2012-04-16 | 2013-10-17 | Dance Pharmaceuticals, Inc. | Methods and systems for supplying aerosolization devices with liquid medicaments |
US20140124087A1 (en) * | 2012-11-08 | 2014-05-08 | Nordson Corporation | Fluid delivery assemblies for withdrawing biomaterial fluid from a vial and for dispensing the biomaterial fluid, fluid control devices therefor, and related methods |
US20170340869A1 (en) * | 2013-03-26 | 2017-11-30 | George Naoum | Device and Method of Controlled Provision of Therapeutic Liquid in the Nose |
US10537719B2 (en) * | 2013-03-26 | 2020-01-21 | George Naoum | Device and method of controlled provision of therapeutic liquid in the nose |
US20160279332A1 (en) * | 2013-11-01 | 2016-09-29 | Consort Medical Plc | Medicament delivery device sub-assembly |
US20160318051A1 (en) * | 2014-01-13 | 2016-11-03 | Aptar France Sas | Method for using an assembly for dispensing a fluid product |
US11559821B2 (en) * | 2014-01-13 | 2023-01-24 | Aptar France Sas | Method for using an assembly for dispensing a fluid product |
CN105848787A (en) * | 2014-01-13 | 2016-08-10 | 阿普塔尔法国简易股份公司 | Method for using an assembly for dispensing a fluid product |
FR3016304A1 (en) * | 2014-01-13 | 2015-07-17 | Aptar France Sas | FLUID PRODUCT DISPENSING ASSEMBLY AND METHOD OF USING SUCH ASSEMBLY. |
WO2015104511A1 (en) | 2014-01-13 | 2015-07-16 | Aptar France Sas | Method for using an assembly for dispensing a fluid product |
US20180064898A1 (en) * | 2015-03-31 | 2018-03-08 | Fisher & Paykel Healthcare Limited | Nasal cannula |
US11420002B2 (en) * | 2015-03-31 | 2022-08-23 | Fisher & Paykel Healthcare Limited | Nasal cannula |
US10912914B2 (en) | 2019-06-06 | 2021-02-09 | GE Precision Healthcare LLC | Systems and methods for bottle retention |
EP4052746A4 (en) * | 2019-11-06 | 2023-11-22 | Nipro Corporation | Syringe-type ejection device |
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Owner name: SMITHKLINE BECKMAN CORPORATION Free format text: CHANGE OF NAME;ASSIGNOR:SMITHKLINE CORPORATION;REEL/FRAME:004080/0769 Effective date: 19820304 Owner name: SMITHKLINE BECKMAN CORPORATION, PENNSYLVANIA Free format text: CHANGE OF NAME;ASSIGNOR:SMITHKLINE CORPORATION;REEL/FRAME:004080/0769 Effective date: 19820304 |