US20110014719A1 - Cartridge for assays with magnetic particles - Google Patents

Cartridge for assays with magnetic particles Download PDF

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Publication number
US20110014719A1
US20110014719A1 US12/922,887 US92288709A US2011014719A1 US 20110014719 A1 US20110014719 A1 US 20110014719A1 US 92288709 A US92288709 A US 92288709A US 2011014719 A1 US2011014719 A1 US 2011014719A1
Authority
US
United States
Prior art keywords
cartridge
magnetic
sample
magnetic particles
reservoirs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US12/922,887
Other languages
English (en)
Inventor
Mara Johanna Jacoba Sijbers
Petrus Johannes Wilhelmus Van Lankvelt
Femke Karina de Theije
Jeroen Hans Nieuwenhuis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke Philips NV
Original Assignee
Koninklijke Philips Electronics NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Philips Electronics NV filed Critical Koninklijke Philips Electronics NV
Assigned to KONINKLIJKE PHILIPS ELECTRONICS N V reassignment KONINKLIJKE PHILIPS ELECTRONICS N V ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: NIEUWENHUIS, JEROEN HANS, VAN LANKVELT, PETRUS JOHANNES WILHELMUS, DE THEIJE, FEMKE KARINA, SIJBERS, MARA JOHANNA JACOBA
Publication of US20110014719A1 publication Critical patent/US20110014719A1/en
Abandoned legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/28—Magnetic plugs and dipsticks
    • B03C1/282—Magnetic plugs and dipsticks with associated accumulation indicator, e.g. Hall sensor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/28—Magnetic plugs and dipsticks
    • B03C1/288—Magnetic plugs and dipsticks disposed at the outer circumference of a recipient
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/72—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables
    • G01N27/74—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids
    • G01N27/745—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids for detecting magnetic beads used in biochemical assays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/946—CNS-stimulants, e.g. cocaine, amphetamines
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/948—Sedatives, e.g. cannabinoids, barbiturates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9486—Analgesics, e.g. opiates, aspirine
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/18—Magnetic separation whereby the particles are suspended in a liquid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/26—Details of magnetic or electrostatic separation for use in medical applications

Definitions

  • the sensitive zones i.e. at least two sensitive zones are preferably specific with respect to different target components. These zones may for example be coated with binding sites (capture molecules) that specifically bind to different target components in the sample. Thus it is possible to screen a sample in parallel for different target components.
  • the invention further relates to a sensor device for the detection of target components in a liquid sample, comprising the following components:
  • FIG. 1 shows a top view onto a first cartridge according to the present invention in which particle reservoirs and sensitive zones are located on a top part and a bottom part, respectively;

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Electrochemistry (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
US12/922,887 2008-03-17 2009-03-11 Cartridge for assays with magnetic particles Abandoned US20110014719A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08102671.8 2008-03-17
EP08102671 2008-03-17
PCT/IB2009/051021 WO2009115951A1 (en) 2008-03-17 2009-03-11 Cartridge for assays with magnetic particles

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2009/051021 A-371-Of-International WO2009115951A1 (en) 2008-03-17 2009-03-11 Cartridge for assays with magnetic particles

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US15/184,280 Continuation US10006907B2 (en) 2008-03-17 2016-06-16 Cartridge for assays with magnetic particles

Publications (1)

Publication Number Publication Date
US20110014719A1 true US20110014719A1 (en) 2011-01-20

Family

ID=40641647

Family Applications (2)

Application Number Title Priority Date Filing Date
US12/922,887 Abandoned US20110014719A1 (en) 2008-03-17 2009-03-11 Cartridge for assays with magnetic particles
US15/184,280 Active 2029-05-06 US10006907B2 (en) 2008-03-17 2016-06-16 Cartridge for assays with magnetic particles

Family Applications After (1)

Application Number Title Priority Date Filing Date
US15/184,280 Active 2029-05-06 US10006907B2 (en) 2008-03-17 2016-06-16 Cartridge for assays with magnetic particles

Country Status (8)

Country Link
US (2) US20110014719A1 (ru)
EP (1) EP2263084B1 (ru)
JP (1) JP5628784B2 (ru)
CN (1) CN101978267B (ru)
BR (1) BRPI0909791A8 (ru)
RU (1) RU2505816C2 (ru)
WO (1) WO2009115951A1 (ru)
ZA (1) ZA201007366B (ru)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100132438A1 (en) * 2008-11-28 2010-06-03 Roche Diagnostics Operations, Inc. System and method for the automated processing of fluids, method for determining the matching of objects
US20130088221A1 (en) * 2010-06-22 2013-04-11 Koninklijke Philips Electronics N.V. Detection of magnetic particles and their clustering
US20130109030A1 (en) * 2010-07-05 2013-05-02 Koninklijke Philips Electronics N.V. Examination system with sample incubation
CN104407113A (zh) * 2014-11-04 2015-03-11 上海交通大学 食品中致病菌检测的微型化磁通门生物传感器
US9567626B2 (en) 2012-01-04 2017-02-14 Magnomics, S.A. Monolithic device combining CMOS with magnetoresistive sensors
US9702748B2 (en) 2015-10-14 2017-07-11 International Business Machines Corporation Graphene-based magnetic hall sensor for fluid flow analysis at nanoscale level
US20170261503A1 (en) * 2016-03-11 2017-09-14 Qorvo Us, Inc. Baw sensor fluidic device with increased dynamic measurement range
US10261076B2 (en) * 2015-10-02 2019-04-16 The Board Of Trustees Of The Leland Stanford Junior University Method for detecting small molecule analytes using magnetoresistant sensors
US20220047794A1 (en) * 2019-02-22 2022-02-17 Tdk Corporation Blood purification device and purification method of blood
US11977086B2 (en) 2019-03-21 2024-05-07 Hound Labs, Inc. Biomarker detection from breath samples

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2329269A1 (en) * 2008-09-26 2011-06-08 Koninklijke Philips Electronics N.V. Magnetic-label sensor and cartridge
RU2011121883A (ru) * 2008-10-31 2012-12-10 Конинклейке Филипс Электроникс Н.В. Биосенсор с многокамерным контейнером
EP2480887B1 (en) 2009-09-23 2015-12-16 Koninklijke Philips N.V. Binding assay with multiple magnetically labelled tracer binding agents
US10876964B2 (en) * 2009-12-18 2020-12-29 Koninklijke Philips N.V. System, apparatus and method for determining a substance within a fluid
CN103229056B (zh) 2010-11-30 2015-06-24 皇家飞利浦电子股份有限公司 用于磁致动粒子的传感器装置
EP2541230A1 (en) * 2011-06-30 2013-01-02 Koninklijke Philips Electronics N.V. Detection of clusters of magnetic particles
BR112014017140A8 (pt) * 2012-01-16 2017-07-04 Koninklijke Philips Nv método de determinação da presença de moléculas alvo em um fluido corporal compreendendo células; cartucho para inserção em um dispositivo analisador; e dispositivo analisador
CN102600966A (zh) * 2012-03-06 2012-07-25 南昌大学 简易磁珠分离装置
CN102600967A (zh) * 2012-03-06 2012-07-25 南昌大学 一种智能控制磁分离器
US10816550B2 (en) 2012-10-15 2020-10-27 Nanocellect Biomedical, Inc. Systems, apparatus, and methods for sorting particles
CN102935996B (zh) * 2012-10-18 2015-04-22 上海交通大学 血清肿瘤标志物检测的微型化磁通门生物传感器制作方法
JP2014232032A (ja) * 2013-05-29 2014-12-11 独立行政法人国立長寿医療研究センター 化学・物理現象検出方法及びその装置
RU2569766C2 (ru) * 2014-01-24 2015-11-27 Общество с ограниченной ответственностью "Химмотолог" Устройство для автоматического определения качества смазочных материалов
JP6594995B2 (ja) * 2015-03-26 2019-10-23 コーニンクレッカ フィリップス エヌ ヴェ バイオセンサカートリッジの製造

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US6300138B1 (en) * 1997-08-01 2001-10-09 Qualigen, Inc. Methods for conducting tests
US20030190608A1 (en) * 1999-11-12 2003-10-09 Gary Blackburn Microfluidic devices comprising biochannels
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US20080009766A1 (en) * 2005-05-09 2008-01-10 Holmes Elizabeth A Systems and methods for improving medical treatments

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US5981297A (en) * 1997-02-05 1999-11-09 The United States Of America As Represented By The Secretary Of The Navy Biosensor using magnetically-detected label
US6300138B1 (en) * 1997-08-01 2001-10-09 Qualigen, Inc. Methods for conducting tests
US20030190608A1 (en) * 1999-11-12 2003-10-09 Gary Blackburn Microfluidic devices comprising biochannels
US20040197845A1 (en) * 2002-08-30 2004-10-07 Arjang Hassibi Methods and apparatus for pathogen detection, identification and/or quantification
US20080009766A1 (en) * 2005-05-09 2008-01-10 Holmes Elizabeth A Systems and methods for improving medical treatments

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100132438A1 (en) * 2008-11-28 2010-06-03 Roche Diagnostics Operations, Inc. System and method for the automated processing of fluids, method for determining the matching of objects
US9086396B2 (en) * 2008-11-28 2015-07-21 Roche Molecular Systems, Inc. System and method for the automated processing of fluids, method for determining the matching of objects
US9377479B2 (en) 2008-11-28 2016-06-28 Roche Molecular Systems, Inc. System and method for the automated processing of fluids, method for determining the matching of objects
US20130088221A1 (en) * 2010-06-22 2013-04-11 Koninklijke Philips Electronics N.V. Detection of magnetic particles and their clustering
US20130109030A1 (en) * 2010-07-05 2013-05-02 Koninklijke Philips Electronics N.V. Examination system with sample incubation
US9567626B2 (en) 2012-01-04 2017-02-14 Magnomics, S.A. Monolithic device combining CMOS with magnetoresistive sensors
CN104407113A (zh) * 2014-11-04 2015-03-11 上海交通大学 食品中致病菌检测的微型化磁通门生物传感器
US10261076B2 (en) * 2015-10-02 2019-04-16 The Board Of Trustees Of The Leland Stanford Junior University Method for detecting small molecule analytes using magnetoresistant sensors
US9702748B2 (en) 2015-10-14 2017-07-11 International Business Machines Corporation Graphene-based magnetic hall sensor for fluid flow analysis at nanoscale level
US9891294B2 (en) 2015-10-14 2018-02-13 International Business Machines Corporation Graphene-based magnetic hall sensor for fluid flow analysis at nanoscale level
US9891084B2 (en) 2015-10-14 2018-02-13 International Business Machines Corporation Graphene-based magnetic hall sensor for fluid flow analysis at nanoscale level
US20170261503A1 (en) * 2016-03-11 2017-09-14 Qorvo Us, Inc. Baw sensor fluidic device with increased dynamic measurement range
US10578614B2 (en) * 2016-03-11 2020-03-03 Qorvo Biotechnologies, Llc BAW sensor fluidic device with increased dynamic measurement range
US20220047794A1 (en) * 2019-02-22 2022-02-17 Tdk Corporation Blood purification device and purification method of blood
US11977086B2 (en) 2019-03-21 2024-05-07 Hound Labs, Inc. Biomarker detection from breath samples

Also Published As

Publication number Publication date
RU2010142278A (ru) 2012-04-27
EP2263084B1 (en) 2017-02-22
JP2011516832A (ja) 2011-05-26
RU2505816C2 (ru) 2014-01-27
BRPI0909791A2 (pt) 2015-08-11
CN101978267A (zh) 2011-02-16
ZA201007366B (en) 2012-03-28
BRPI0909791A8 (pt) 2016-08-02
JP5628784B2 (ja) 2014-11-19
EP2263084A1 (en) 2010-12-22
WO2009115951A1 (en) 2009-09-24
CN101978267B (zh) 2017-04-26
US20160291004A1 (en) 2016-10-06
US10006907B2 (en) 2018-06-26

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Owner name: KONINKLIJKE PHILIPS ELECTRONICS N V, NETHERLANDS

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:SIJBERS, MARA JOHANNA JACOBA;VAN LANKVELT, PETRUS JOHANNES WILHELMUS;DE THEIJE, FEMKE KARINA;AND OTHERS;SIGNING DATES FROM 20100602 TO 20100707;REEL/FRAME:024997/0064

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION