US20090163586A1 - Bis-(Sulfonylamino) Derivatives in Therapy 205 - Google Patents
Bis-(Sulfonylamino) Derivatives in Therapy 205 Download PDFInfo
- Publication number
- US20090163586A1 US20090163586A1 US12/337,125 US33712508A US2009163586A1 US 20090163586 A1 US20090163586 A1 US 20090163586A1 US 33712508 A US33712508 A US 33712508A US 2009163586 A1 US2009163586 A1 US 2009163586A1
- Authority
- US
- United States
- Prior art keywords
- benzenesulfonamide
- phenyl
- sulfonylamino
- fluoro
- ethenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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Definitions
- the present invention relates to bis-(sulfonylamino) derivatives, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
- G 3 is phenyl, pyridyl or 2-methyl-1,3,4-oxadiazole
- G 2 represents H, phenyl or 5- or 6-membered heteroaryl; optionally fused to one further ring independently selected from phenyl, a 5- or 6-membered heteroaryl, C 5-6 carbocyclyl or C 5-6 heterocyclyl ring; and any phenyl or heteroaryl moieties in G 1 and G 2 are optionally substituted by one or more substituents independently selected from halogen, C 1-6 alkyl and C 1-6 alkoxy; said C 1-6 alkyl being optionally substituted by OH or by one or more F atoms.
- n an integer 0, 1, 2, 3 or 4;
- neuropathic pain therapies including for example gabapentin, lidoderm, pregablin and equivalents and pharmaceutically active isomer(s) and metabolite(s) thereof.
- R 3 , R 5 , R 6 and R 10 represents hydrogen
- G 3 represents phenyl or 5- or 6-membered heteroaryl
- n-Butyllithium (59.0 mL, 1.6M solution in hexanes) was added dropwise during 25 min to a solution of ethylmethanesulfonate (9.1 mL, 86 mmol) in THF (200 mL) at ⁇ 78° C.
- the reaction mixture was stirred for 15 min then diethyl chlorophosphate (7.2 ml, 50 mmol) was added dropwise.
- the solution was stirred at ⁇ 78° C. for 30 min, allowed to warm to 0° C. and then cooled to ⁇ 78° C. again.
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- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
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- Urology & Nephrology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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Priority Applications (1)
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US12/337,125 US20090163586A1 (en) | 2007-12-20 | 2008-12-17 | Bis-(Sulfonylamino) Derivatives in Therapy 205 |
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US1528707P | 2007-12-20 | 2007-12-20 | |
US12/337,125 US20090163586A1 (en) | 2007-12-20 | 2008-12-17 | Bis-(Sulfonylamino) Derivatives in Therapy 205 |
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Cited By (5)
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US20100292279A1 (en) * | 2009-05-14 | 2010-11-18 | Astrazeneca Ab | Bis-(Sulfonylamino) Derivatives in Therapy |
US20110021540A1 (en) * | 2007-11-15 | 2011-01-27 | Astrazeneca Ab | Bis-(Sulfonylamino) Derivatives in Therapy 066 |
WO2014062044A1 (en) | 2012-10-15 | 2014-04-24 | Vilnius University | Fluorinated benzenesulfonamides as inhibitors of carbonic anhydrase |
WO2016085391A1 (en) * | 2014-11-27 | 2016-06-02 | Acturum Life Science AB | Bis(sulfonamide) derivatives and their use as mpges inhibitors |
WO2016085392A1 (en) * | 2014-11-27 | 2016-06-02 | Acturum Life Science AB | Bis(sulfonamide) derivatives and their use as mpges inhibitors |
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WO2010144959A1 (en) * | 2009-06-18 | 2010-12-23 | Fibrotech Therapeutics Pty Ltd | Analogues of anti-fibrotic agents |
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- 2008-12-18 TW TW097149496A patent/TW200932210A/zh unknown
- 2008-12-18 US US12/747,049 patent/US9145380B2/en not_active Expired - Fee Related
- 2008-12-18 JP JP2010539383A patent/JP5555175B2/ja not_active Expired - Fee Related
- 2008-12-18 ES ES08863493T patent/ES2397502T3/es active Active
- 2008-12-18 EP EP08863493A patent/EP2234993B1/en active Active
- 2008-12-18 CN CN200880127180.2A patent/CN101945859B/zh not_active Expired - Fee Related
- 2008-12-18 KR KR1020107016075A patent/KR20100098711A/ko not_active Application Discontinuation
- 2008-12-18 UY UY31546A patent/UY31546A1/es unknown
- 2008-12-18 AU AU2008341173A patent/AU2008341173B2/en not_active Ceased
- 2008-12-18 WO PCT/SE2008/051500 patent/WO2009082347A1/en active Application Filing
- 2008-12-18 PE PE2008002126A patent/PE20091175A1/es not_active Application Discontinuation
- 2008-12-18 EA EA201001013A patent/EA017940B1/ru not_active IP Right Cessation
- 2008-12-18 BR BRPI0821299-6A patent/BRPI0821299A2/pt not_active IP Right Cessation
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- 2010-06-14 ZA ZA2010/04226A patent/ZA201004226B/en unknown
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- 2010-06-18 NI NI201000109A patent/NI201000109A/es unknown
- 2010-06-18 CR CR11517A patent/CR11517A/es not_active Application Discontinuation
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2011
- 2011-04-01 HK HK11103327.5A patent/HK1149259A1/en not_active IP Right Cessation
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US20110021540A1 (en) * | 2007-11-15 | 2011-01-27 | Astrazeneca Ab | Bis-(Sulfonylamino) Derivatives in Therapy 066 |
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US9725467B2 (en) | 2012-10-15 | 2017-08-08 | Vilnius University | Fluorinated benzenesulfonamides as inhibitors of carbonic anhydrase |
WO2016085391A1 (en) * | 2014-11-27 | 2016-06-02 | Acturum Life Science AB | Bis(sulfonamide) derivatives and their use as mpges inhibitors |
WO2016085392A1 (en) * | 2014-11-27 | 2016-06-02 | Acturum Life Science AB | Bis(sulfonamide) derivatives and their use as mpges inhibitors |
US10081614B2 (en) | 2014-11-27 | 2018-09-25 | Acturum Real Estate Ab | Bis(sulfonamide) derivatives and their use as mPGES inhibitors |
US10227296B2 (en) | 2014-11-27 | 2019-03-12 | Arcturum Real Estate AB | Bis(sulfonamide) derivatives and their use as mPGES inhibitors |
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EA201001013A1 (ru) | 2010-12-30 |
HK1149259A1 (en) | 2011-09-30 |
CA2709510A1 (en) | 2009-07-02 |
BRPI0821299A2 (pt) | 2015-06-16 |
DOP2010000191A (es) | 2010-08-31 |
EP2234993A4 (en) | 2012-02-08 |
UY31546A1 (es) | 2009-08-03 |
JP2011507837A (ja) | 2011-03-10 |
ES2397502T3 (es) | 2013-03-07 |
EP2234993A1 (en) | 2010-10-06 |
NI201000109A (es) | 2012-05-14 |
AU2008341173B2 (en) | 2011-12-15 |
CO6270307A2 (es) | 2011-04-20 |
KR20100098711A (ko) | 2010-09-08 |
ZA201004226B (en) | 2011-04-28 |
EP2234993B1 (en) | 2012-11-07 |
CR11517A (es) | 2010-08-05 |
TW200932210A (en) | 2009-08-01 |
IL205758A0 (en) | 2010-11-30 |
PE20091175A1 (es) | 2009-09-03 |
EA017940B1 (ru) | 2013-04-30 |
AU2008341173A1 (en) | 2009-07-02 |
US9145380B2 (en) | 2015-09-29 |
US20100331321A1 (en) | 2010-12-30 |
JP5555175B2 (ja) | 2014-07-23 |
ECSP10010272A (es) | 2010-08-31 |
CL2008003848A1 (es) | 2010-02-05 |
CN101945859A (zh) | 2011-01-12 |
CN101945859B (zh) | 2014-04-09 |
WO2009082347A1 (en) | 2009-07-02 |
AR069919A1 (es) | 2010-03-03 |
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