US20090071905A1 - Methods of Making and Using Filtering Unit for a Virucide Substance - Google Patents

Methods of Making and Using Filtering Unit for a Virucide Substance Download PDF

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Publication number
US20090071905A1
US20090071905A1 US12/053,929 US5392908A US2009071905A1 US 20090071905 A1 US20090071905 A1 US 20090071905A1 US 5392908 A US5392908 A US 5392908A US 2009071905 A1 US2009071905 A1 US 2009071905A1
Authority
US
United States
Prior art keywords
polymer
hydrophilic
filter medium
copolymer
biological fluid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US12/053,929
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English (en)
Inventor
Francis Goudaliez
Thierry Verpoort
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Maco Pharma SAS
Original Assignee
Maco Pharma SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Maco Pharma SAS filed Critical Maco Pharma SAS
Priority to US12/053,929 priority Critical patent/US20090071905A1/en
Assigned to MACOPHARMA reassignment MACOPHARMA ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: GOUDALIEZ, FRANCIS, VERPOORT, THIERRY
Publication of US20090071905A1 publication Critical patent/US20090071905A1/en
Priority to US13/089,636 priority patent/US8986237B2/en
Abandoned legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D39/00—Filtering material for liquid or gaseous fluids
    • B01D39/14—Other self-supporting filtering material ; Other filtering material
    • B01D39/16—Other self-supporting filtering material ; Other filtering material of organic material, e.g. synthetic fibres
    • B01D39/1607—Other self-supporting filtering material ; Other filtering material of organic material, e.g. synthetic fibres the material being fibrous
    • B01D39/1623—Other self-supporting filtering material ; Other filtering material of organic material, e.g. synthetic fibres the material being fibrous of synthetic origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0017—Filtration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3681—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation
    • A61M1/3683—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation using photoactive agents
    • A61M1/3686—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation using photoactive agents by removing photoactive agents after irradiation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/49—Method of mechanical manufacture
    • Y10T29/49826—Assembling or joining

Definitions

  • the virucidal substance has previously been added to a biological fluid, in particular blood plasma, intended to be transfused into a patient.
  • the aim of this addition is to subject the biological fluid to a viral inactivation treatment prior to its transfusion into the patient, so as to inactivate any viruses infecting the biological fluid.
  • a conventional technique for viral inactivation of plasma uses a colouring substance as a virucidal substance, for example methylene blue or one of its derivatives.
  • the invention therefore aims to propose a filtration unit which makes it possible to remove substantially all the virucidal substance present in the biological fluid while leaving the composition of the biological fluid substantially unchanged during the filtration.
  • the object of the invention is a filtration unit intended to remove a virucidal substance present in a biological fluid, comprising an outer casing provided with at least one input aperture and at least one output aperture, the casing containing a filter medium which delimits two compartments, respectively input and output, of the filtration unit, in which the filter medium is produced from at least one hydrophilic material in the form of a porous non-woven material and/or a porous membrane capable of absorbing and/or adsorbing the virucidal substance.
  • the mean porosity of the filter medium is defined so that the contact area between the biological fluid and the filter medium is sufficient to remove substantially all the virucidal substance while leaving the composition of the biological fluid substantially unchanged during its passage through the filter medium, namely being between 1 ⁇ m and 15 ⁇ m.
  • the mean diameter of the fibres of the porous non-woven material is between 0.5 ⁇ m and 5 ⁇ m.
  • the input compartment and/or the output compartment communicate with the outside of the filtration unit by means of an input, respectively output, tube.
  • the filter medium has for example a thickness between 1 and 10 millimetres.
  • FIG. 3 depicts, in top view and transverse section, the embodiment of FIG. 1 , showing in particular the assembly of the frame containing the filter medium in the outer casing.
  • FIG. 4 depicts, in front view and partial longitudinal section, the filtration unit of FIG. 3 in which the spacing rods appear.
  • the biological fluid Prior to its passage into the filtration unit 1 , the biological fluid has undergone a viral inactivation treatment by means of the virucidal substance which was added to the biological fluid.
  • the filtration unit 1 is disposed on the flow path of the biological fluid so that the biological fluid with the virucidal substance added enters the filtration unit 1 by the input aperture 3 and the biological fluid free from the virucidal substance is delivered by means of the output aperture 4 .
  • flexible rods are used, in order not to interfere with the possibilities of folding the filtration unit 1 .
  • the filter medium 5 is produced from at least one hydrophilic material in the form of a porous membrane.
  • the filter medium 5 is produced from a hydrophilic material in the form of at least one porous membrane which is inserted between a number of layers of hydrophilic material in the form of a non-woven material.
  • the polymers and/or the copolymers based on polyester, acrylonitrile or polyvinylidene fluoride can be cited amongst the possible materials: the polymers and/or the copolymers based on polyester, acrylonitrile or polyvinylidene fluoride.
  • the mean size of the pores of the filter medium is chosen according to the biological fluid to be treated.
  • the mean size of the pores can be of the order of or greater than 7 ⁇ m.
  • the mean size of the pores can be smaller, for example of the order of 4 ⁇ m, on account of the absence of cellular constituents in the plasma.
  • the contact area between the biological fluid and the filter medium must be sufficient to remove substantially all the virucidal substance while leaving the composition of the biological fluid substantially unchanged.
  • spunbond and “meltblown” mean two of the conventional methods of forming a layer of non-woven material directly from the polymer, namely respectively either by forming continuous monofilaments or by blowing the polymer in the molten state into irregular filaments.
  • the two outer layers of “spunbond” non-woven material are identical and serve respectively as a pre- and post-filter. Furthermore, they have the function of improving the weldability of the filter medium 5 onto the casing 2 of the filtration unit 1 .

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Anesthesiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • External Artificial Organs (AREA)
  • Filtering Materials (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Centrifugal Separators (AREA)
  • Filtering Of Dispersed Particles In Gases (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
US12/053,929 1999-10-20 2008-03-24 Methods of Making and Using Filtering Unit for a Virucide Substance Abandoned US20090071905A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US12/053,929 US20090071905A1 (en) 1999-10-20 2008-03-24 Methods of Making and Using Filtering Unit for a Virucide Substance
US13/089,636 US8986237B2 (en) 1999-10-20 2011-04-19 Methods of making and using filtering unit for a virucide substance

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
FR9913089A FR2799986B1 (fr) 1999-10-20 1999-10-20 Unite de filtration d'une substance virucide
FRFR99/13089 1999-10-20
PCT/FR2000/002900 WO2001028597A1 (fr) 1999-10-20 2000-10-18 Unite de filtration d'une substance virucide
US11114302A 2002-04-19 2002-04-19
US12/053,929 US20090071905A1 (en) 1999-10-20 2008-03-24 Methods of Making and Using Filtering Unit for a Virucide Substance

Related Parent Applications (3)

Application Number Title Priority Date Filing Date
US10111143 Continuation 2000-10-18
PCT/FR2000/002900 Continuation WO2001028597A1 (fr) 1999-10-20 2000-10-18 Unite de filtration d'une substance virucide
US11114302A Continuation 1999-10-20 2002-04-19

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US13/089,636 Continuation US8986237B2 (en) 1999-10-20 2011-04-19 Methods of making and using filtering unit for a virucide substance

Publications (1)

Publication Number Publication Date
US20090071905A1 true US20090071905A1 (en) 2009-03-19

Family

ID=9551138

Family Applications (2)

Application Number Title Priority Date Filing Date
US12/053,929 Abandoned US20090071905A1 (en) 1999-10-20 2008-03-24 Methods of Making and Using Filtering Unit for a Virucide Substance
US13/089,636 Expired - Fee Related US8986237B2 (en) 1999-10-20 2011-04-19 Methods of making and using filtering unit for a virucide substance

Family Applications After (1)

Application Number Title Priority Date Filing Date
US13/089,636 Expired - Fee Related US8986237B2 (en) 1999-10-20 2011-04-19 Methods of making and using filtering unit for a virucide substance

Country Status (10)

Country Link
US (2) US20090071905A1 (de)
EP (1) EP1093823B1 (de)
JP (1) JP2003512093A (de)
AT (1) ATE367170T1 (de)
AU (1) AU7930500A (de)
CA (1) CA2387848C (de)
DE (1) DE60035560T2 (de)
ES (1) ES2290004T3 (de)
FR (1) FR2799986B1 (de)
WO (1) WO2001028597A1 (de)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170014567A1 (en) * 2014-03-10 2017-01-19 Asahi Kasei Medical Co., Ltd. Blood treatment filter
US9782707B2 (en) 2014-03-24 2017-10-10 Fenwal, Inc. Biological fluid filters having flexible walls and methods for making such filters
US9796166B2 (en) 2014-03-24 2017-10-24 Fenwal, Inc. Flexible biological fluid filters
US9968738B2 (en) 2014-03-24 2018-05-15 Fenwal, Inc. Biological fluid filters with molded frame and methods for making such filters
US10159778B2 (en) 2014-03-24 2018-12-25 Fenwal, Inc. Biological fluid filters having flexible walls and methods for making such filters
US10188782B2 (en) 2013-10-02 2019-01-29 Asahi Kasei Medical Co., Ltd. Blood processing filter and blood processing method
US10376627B2 (en) 2014-03-24 2019-08-13 Fenwal, Inc. Flexible biological fluid filters

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2797403B1 (fr) * 1999-08-09 2002-03-15 Maco Pharma Sa Ligne de transfusion avec moyens de filtration d'une substance colorante integres
ITTO20020736A1 (it) * 2002-08-21 2004-02-22 Fresenius Hemocare Italia Srl Filtro per leucociti e suo impiego per l'impoverimento di prodotti del sangue da leucociti.
EP1579838A4 (de) * 2002-12-12 2007-11-28 Asahi Chemical Ind Virusentfernungs-beutel und virusentfernungs-verfahren unter verwendung desselben
US7534348B2 (en) * 2003-09-12 2009-05-19 Fenwal, Inc. Flow-through removal device and system using such device
EP1685852A1 (de) * 2005-02-01 2006-08-02 Fondation pour la Recherche Diagnostique Set von Einwegbeuteln zur Virusinaktivierung von biologischen Fluids
FR2897783B1 (fr) * 2006-02-24 2008-05-30 Millipore Corp Dispositif pour le controle microbiologique, ensembles de controle et d'incubation le comportant et procede le mettant en oeuvre
CN102302877B (zh) * 2011-06-01 2013-06-12 李红 生物防护过滤介质及其应用
CN105592869B (zh) * 2013-10-03 2018-09-04 旭化成医疗株式会社 血液处理过滤器及血液处理过滤器的制造方法
CN113509919B (zh) * 2021-05-01 2023-01-10 南开大学 一种可用于清除脓毒症患者血液中内毒素和炎症因子的吸附剂及其制备方法

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4159954A (en) * 1978-02-24 1979-07-03 Gangemi Ronald J Isolator filter
US4276170A (en) * 1978-08-16 1981-06-30 Critikon, Inc. Vented flexible filtration device for use in administering parenteral liquids
US4701267A (en) * 1984-03-15 1987-10-20 Asahi Medical Co., Ltd. Method for removing leukocytes
US4925572A (en) * 1987-10-20 1990-05-15 Pall Corporation Device and method for depletion of the leukocyte content of blood and blood components
US4985153A (en) * 1988-06-23 1991-01-15 Asahi Medical Co., Ltd. Method for separating blood into blood components, and blood components separator unit
US5234593A (en) * 1989-09-18 1993-08-10 Terumo Kabushiki Kaisha Filter for purification of platelets
US5478470A (en) * 1991-08-22 1995-12-26 Asahi Medical Co., Ltd. Filter material for selectively removing leukocytes
US5639376A (en) * 1994-01-10 1997-06-17 Hemasure, Inc. Process for simultaneously removing leukocytes and methylene blue from plasma
US5858641A (en) * 1996-09-17 1999-01-12 Shanbrom Technologies, Llc Disinfectant dye removal from blood and blood fractions using a porous poly(vinyl alcohol-acetal) copolymer
US6197207B1 (en) * 1997-05-21 2001-03-06 Baxter International Inc. Method of reducing the possibility of transmission of spongiform encephalopathy diseases by blood products
US6328167B1 (en) * 1998-12-28 2001-12-11 Fuji Photo Film Co., Ltd. Blood filter cartridge

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6319662B1 (en) * 1993-12-17 2001-11-20 Baxter International Inc. Method and apparatus for removing viral contaminants from a body fluid
US6190855B1 (en) * 1996-10-28 2001-02-20 Baxter International Inc. Systems and methods for removing viral agents from blood
AU1056397A (en) * 1996-11-20 1998-06-10 Edward Shanbrom Trace capture in biological fluids

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4159954A (en) * 1978-02-24 1979-07-03 Gangemi Ronald J Isolator filter
US4276170A (en) * 1978-08-16 1981-06-30 Critikon, Inc. Vented flexible filtration device for use in administering parenteral liquids
US4701267B1 (en) * 1984-03-15 1996-03-12 Asahi Medical Co Method for removing leukocytes
US4701267A (en) * 1984-03-15 1987-10-20 Asahi Medical Co., Ltd. Method for removing leukocytes
US4925572A (en) * 1987-10-20 1990-05-15 Pall Corporation Device and method for depletion of the leukocyte content of blood and blood components
US4985153A (en) * 1988-06-23 1991-01-15 Asahi Medical Co., Ltd. Method for separating blood into blood components, and blood components separator unit
US5234593A (en) * 1989-09-18 1993-08-10 Terumo Kabushiki Kaisha Filter for purification of platelets
US5478470A (en) * 1991-08-22 1995-12-26 Asahi Medical Co., Ltd. Filter material for selectively removing leukocytes
US5665233A (en) * 1991-08-22 1997-09-09 Asahi Medical Co., Ltd. Filter apparatus for selectively removing leukocytes
US5639376A (en) * 1994-01-10 1997-06-17 Hemasure, Inc. Process for simultaneously removing leukocytes and methylene blue from plasma
US5858641A (en) * 1996-09-17 1999-01-12 Shanbrom Technologies, Llc Disinfectant dye removal from blood and blood fractions using a porous poly(vinyl alcohol-acetal) copolymer
US6197207B1 (en) * 1997-05-21 2001-03-06 Baxter International Inc. Method of reducing the possibility of transmission of spongiform encephalopathy diseases by blood products
US6328167B1 (en) * 1998-12-28 2001-12-11 Fuji Photo Film Co., Ltd. Blood filter cartridge

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10188782B2 (en) 2013-10-02 2019-01-29 Asahi Kasei Medical Co., Ltd. Blood processing filter and blood processing method
US20170014567A1 (en) * 2014-03-10 2017-01-19 Asahi Kasei Medical Co., Ltd. Blood treatment filter
CN108635629A (zh) * 2014-03-10 2018-10-12 旭化成医疗株式会社 血液处理过滤器
US10842927B2 (en) * 2014-03-10 2020-11-24 Asahi Kasei Medical Co., Ltd. Blood treatment filter
US11504460B2 (en) * 2014-03-10 2022-11-22 Asahi Kasei Medical Co., Ltd. Blood treatment filter
US9782707B2 (en) 2014-03-24 2017-10-10 Fenwal, Inc. Biological fluid filters having flexible walls and methods for making such filters
US9796166B2 (en) 2014-03-24 2017-10-24 Fenwal, Inc. Flexible biological fluid filters
US9968738B2 (en) 2014-03-24 2018-05-15 Fenwal, Inc. Biological fluid filters with molded frame and methods for making such filters
US10159778B2 (en) 2014-03-24 2018-12-25 Fenwal, Inc. Biological fluid filters having flexible walls and methods for making such filters
US10183475B2 (en) 2014-03-24 2019-01-22 Fenwal, Inc. Flexible biological fluid filters
US10343093B2 (en) 2014-03-24 2019-07-09 Fenwal, Inc. Biological fluid filters having flexible walls and methods for making such filters
US10376627B2 (en) 2014-03-24 2019-08-13 Fenwal, Inc. Flexible biological fluid filters

Also Published As

Publication number Publication date
JP2003512093A (ja) 2003-04-02
DE60035560T2 (de) 2008-04-17
US8986237B2 (en) 2015-03-24
WO2001028597A1 (fr) 2001-04-26
FR2799986B1 (fr) 2001-11-23
EP1093823A1 (de) 2001-04-25
CA2387848C (en) 2008-10-07
AU7930500A (en) 2001-04-30
ES2290004T3 (es) 2008-02-16
CA2387848A1 (en) 2001-04-26
US20110192798A1 (en) 2011-08-11
ATE367170T1 (de) 2007-08-15
DE60035560D1 (de) 2007-08-30
EP1093823B1 (de) 2007-07-18
FR2799986A1 (fr) 2001-04-27

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AS Assignment

Owner name: MACOPHARMA, FRANCE

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:GOUDALIEZ, FRANCIS;VERPOORT, THIERRY;REEL/FRAME:022095/0201

Effective date: 20020409

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION