US20080199440A1 - Tissue Repair Using Allogenic Dermal Fibroblasts - Google Patents

Tissue Repair Using Allogenic Dermal Fibroblasts Download PDF

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Publication number
US20080199440A1
US20080199440A1 US11/915,514 US91551406A US2008199440A1 US 20080199440 A1 US20080199440 A1 US 20080199440A1 US 91551406 A US91551406 A US 91551406A US 2008199440 A1 US2008199440 A1 US 2008199440A1
Authority
US
United States
Prior art keywords
fibroblasts
dermal
subject
tissue
suspension
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US11/915,514
Other languages
English (en)
Inventor
Mike Leek
Paul Kemp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Intercytex Ltd
Original Assignee
Intercytex Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0510714A external-priority patent/GB0510714D0/en
Priority claimed from GB0521491A external-priority patent/GB0521491D0/en
Application filed by Intercytex Ltd filed Critical Intercytex Ltd
Assigned to INTERCYTEX LIMITED reassignment INTERCYTEX LIMITED ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: KEMP, PAUL, LEEK, MIKE
Publication of US20080199440A1 publication Critical patent/US20080199440A1/en
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/10—Hair or skin implants
    • A61F2/105—Skin implants, e.g. artificial skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
    • A61K8/985—Skin or skin outgrowth, e.g. hair, nails
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/60—Materials for use in artificial skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/91—Injection

Definitions

  • the most widely used dermal filler is the xenograft biological material bovine collagen.
  • Commercial products comprise purified, enzyme-digested collagen (predominantly type I, with less than 5% type III collagen), and are available as Zyderm and Zyplast from Inamed Aesthetics (Santa Barbara, Calif., USA).
  • Zyderm is processed to remove by enzymatic degradation the C- and N-terminal peptides of bovine collagen, which are immunogenic in human subjects, thereby yielding a material called atelocollagen that can be used in pre-screened non-reactive subjects (see U.S. Pat. No. 3,949,073; U.S. Pat. No. 4,424,208; and U.S. Pat. No.
  • Hyaluronic acid is a glycosaminoglycan macromolecule found in the native extracellular matrix of connective tissue.
  • the macromolecule is composed of chains of repeating disaccharide units and due to its hydrophobic structure attracts water into the extracellular matrix to provide turgor to connective tissue.
  • hyaluronic acid is identical in structure across different species, thereby reducing the possibility of antigenic cross-reactivity in a host, it undergoes local degradation after transplantation.
  • the present invention provides an alternative and simplified method for the repair of subcutaneous or dermal tissue in a subject, comprising in one aspect the injection of a suspension of allogeneic dermal fibroblasts into the subject.
  • the invention provides, for example, long-term augmentation of the subadjacent tissue without the disadvantages that accompany the preparation and/or use of presently available materials.
  • the treatment of fine superficial facial lines can be accomplished as follows.
  • the area to be treated is prepped with alcohol and stretched to give a taut surface.
  • a syringe is filled with a cell suspension and fitted with a 30 ga. needle for injection.
  • the needle is inserted into the skin site as superficially as possible; the orientation of the bevel is not critical.
  • An intradermal injection is made by gentle pressure until a slight blanch is seen. Multiple serial injections are made.
  • the injectate can be placed in the obicularis musculature, to treat hypoplasia of the lip or into the subcutaneous tissue to treat deep subcutaneous defects.
  • a larger or narrower gauge needle than 30 ga. may be used.
  • a fibroblast-containing suspension or a fibroblast-containing gel or a fibroblast-containing clot (for example, as prepared according to Section 4.2 of U.S. Pat. No. 5,591,444, which is hereby incorporated by reference in its entirety) is fashioned so as to cover the abraded surface and applied so that the fibroblast-seeded side of the suspension, gel or clot is juxtaposed to the abraded dermal surface.
  • the applied suspension, gel or clot is then covered with a surgical dressing such as Xeroform, Adaptic or any nonocclusive surgical dressing.
US11/915,514 2005-05-26 2006-05-25 Tissue Repair Using Allogenic Dermal Fibroblasts Abandoned US20080199440A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0510714A GB0510714D0 (en) 2005-05-26 2005-05-26 Tissue repair
GB0510714.9 2005-05-26
GB0521491.1 2005-10-21
GB0521491A GB0521491D0 (en) 2005-10-21 2005-10-21 Tissue repair
PCT/GB2006/001916 WO2006125991A1 (en) 2005-05-26 2006-05-25 Tissue repair using allogenic dermal fibroblasts

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2006/001916 A-371-Of-International WO2006125991A1 (en) 2005-05-26 2006-05-25 Tissue repair using allogenic dermal fibroblasts

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US13/791,177 Continuation US9271923B2 (en) 2005-05-26 2013-03-08 Tissue repair using allogeneic dermal fibroblasts

Publications (1)

Publication Number Publication Date
US20080199440A1 true US20080199440A1 (en) 2008-08-21

Family

ID=36607531

Family Applications (2)

Application Number Title Priority Date Filing Date
US11/915,514 Abandoned US20080199440A1 (en) 2005-05-26 2006-05-25 Tissue Repair Using Allogenic Dermal Fibroblasts
US13/791,177 Expired - Fee Related US9271923B2 (en) 2005-05-26 2013-03-08 Tissue repair using allogeneic dermal fibroblasts

Family Applications After (1)

Application Number Title Priority Date Filing Date
US13/791,177 Expired - Fee Related US9271923B2 (en) 2005-05-26 2013-03-08 Tissue repair using allogeneic dermal fibroblasts

Country Status (7)

Country Link
US (2) US20080199440A1 (ja)
EP (1) EP1885280A1 (ja)
JP (1) JP2008542252A (ja)
AU (1) AU2006251004C1 (ja)
CA (1) CA2609507C (ja)
GB (1) GB2426452B (ja)
WO (1) WO2006125991A1 (ja)

Cited By (2)

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US8532084B2 (en) 2006-01-18 2013-09-10 Huawei Technologies Co., Ltd. Method and system for synchronization in communication system
US11554142B2 (en) * 2010-05-07 2023-01-17 Castle Creek Biosciences, Llc Dosage unit formulations of autologous dermal fibroblasts

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TR200602727A2 (tr) * 2006-05-31 2007-12-24 Tun� T�Ryak� Kemal Cilt defektleri ve yaşlanması tedavisinde kullanılacak bir yöntem ve bir doku maddesi
KR20070122315A (ko) * 2006-06-26 2007-12-31 (주) 에스바이오메딕스 자가 진피 세포 및 히알루론산을 함유하는 주사용 인체연조직 충전제 조성물
WO2008027984A1 (en) 2006-08-29 2008-03-06 Isolagen Technologies, Inc. Methods for culturing minimally-passaged fibroblasts and uses thereof
GB0822246D0 (en) * 2008-12-05 2009-01-14 Reneuron Ltd Composition
GB0902034D0 (en) 2009-02-06 2009-03-11 Reneuron Ltd Method
FR2948286B1 (fr) * 2009-07-27 2011-08-26 Jean-Noel Thorel Composition injectable associant un agent de comblement et un milieu de croissance des fibroblastes
EP2404993A1 (en) * 2010-07-09 2012-01-11 Merz Pharma GmbH & Co. KGaA Alginate filler including eukaryotic cells
US20130236427A1 (en) * 2012-03-07 2013-09-12 Fibrocell Technologies, Inc. Topical Dermal Formulations and Methods of Personalized Treatment of Skin
RU2014101757A (ru) * 2014-01-21 2015-07-27 Дауд Меджидович Шамов Способ восстановления ткани
GB2526542A (en) * 2014-05-26 2015-12-02 David Anthony Waghorn Stem cell implanter and absorbable stem cell implant
RU2578804C1 (ru) * 2015-04-27 2016-03-27 Екатерина Евгеньевна Фаустова Способ омоложения организма пациента
RU2617237C2 (ru) * 2015-06-23 2017-04-24 Государственное бюджетное образовательное учреждение высшего профессионального образования "Северный государственный медицинский университет" Министерства здравоохранения Российской Федерации Способ получения препаратов изолированных клеток дермы

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8532084B2 (en) 2006-01-18 2013-09-10 Huawei Technologies Co., Ltd. Method and system for synchronization in communication system
US8897286B2 (en) 2006-01-18 2014-11-25 Huawei Technologies Co., Ltd. Method and system for synchronization in communication system
US9277568B2 (en) 2006-01-18 2016-03-01 Huawei Technologies Co., Ltd. Method, apparatus and system for random access
US10009928B2 (en) 2006-01-18 2018-06-26 Huawei Technologies Co., Ltd. Method, apparatus and system for random access
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