US20080199440A1 - Tissue Repair Using Allogenic Dermal Fibroblasts - Google Patents
Tissue Repair Using Allogenic Dermal Fibroblasts Download PDFInfo
- Publication number
- US20080199440A1 US20080199440A1 US11/915,514 US91551406A US2008199440A1 US 20080199440 A1 US20080199440 A1 US 20080199440A1 US 91551406 A US91551406 A US 91551406A US 2008199440 A1 US2008199440 A1 US 2008199440A1
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- fibroblasts
- dermal
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- tissue
- suspension
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/10—Hair or skin implants
- A61F2/105—Skin implants, e.g. artificial skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
- A61K8/985—Skin or skin outgrowth, e.g. hair, nails
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/60—Materials for use in artificial skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/91—Injection
Definitions
- the most widely used dermal filler is the xenograft biological material bovine collagen.
- Commercial products comprise purified, enzyme-digested collagen (predominantly type I, with less than 5% type III collagen), and are available as Zyderm and Zyplast from Inamed Aesthetics (Santa Barbara, Calif., USA).
- Zyderm is processed to remove by enzymatic degradation the C- and N-terminal peptides of bovine collagen, which are immunogenic in human subjects, thereby yielding a material called atelocollagen that can be used in pre-screened non-reactive subjects (see U.S. Pat. No. 3,949,073; U.S. Pat. No. 4,424,208; and U.S. Pat. No.
- Hyaluronic acid is a glycosaminoglycan macromolecule found in the native extracellular matrix of connective tissue.
- the macromolecule is composed of chains of repeating disaccharide units and due to its hydrophobic structure attracts water into the extracellular matrix to provide turgor to connective tissue.
- hyaluronic acid is identical in structure across different species, thereby reducing the possibility of antigenic cross-reactivity in a host, it undergoes local degradation after transplantation.
- the present invention provides an alternative and simplified method for the repair of subcutaneous or dermal tissue in a subject, comprising in one aspect the injection of a suspension of allogeneic dermal fibroblasts into the subject.
- the invention provides, for example, long-term augmentation of the subadjacent tissue without the disadvantages that accompany the preparation and/or use of presently available materials.
- the treatment of fine superficial facial lines can be accomplished as follows.
- the area to be treated is prepped with alcohol and stretched to give a taut surface.
- a syringe is filled with a cell suspension and fitted with a 30 ga. needle for injection.
- the needle is inserted into the skin site as superficially as possible; the orientation of the bevel is not critical.
- An intradermal injection is made by gentle pressure until a slight blanch is seen. Multiple serial injections are made.
- the injectate can be placed in the obicularis musculature, to treat hypoplasia of the lip or into the subcutaneous tissue to treat deep subcutaneous defects.
- a larger or narrower gauge needle than 30 ga. may be used.
- a fibroblast-containing suspension or a fibroblast-containing gel or a fibroblast-containing clot (for example, as prepared according to Section 4.2 of U.S. Pat. No. 5,591,444, which is hereby incorporated by reference in its entirety) is fashioned so as to cover the abraded surface and applied so that the fibroblast-seeded side of the suspension, gel or clot is juxtaposed to the abraded dermal surface.
- the applied suspension, gel or clot is then covered with a surgical dressing such as Xeroform, Adaptic or any nonocclusive surgical dressing.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Transplantation (AREA)
- Zoology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Birds (AREA)
- Vascular Medicine (AREA)
- Developmental Biology & Embryology (AREA)
- Pharmacology & Pharmacy (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Urology & Nephrology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0510714.9 | 2005-05-26 | ||
GB0510714A GB0510714D0 (en) | 2005-05-26 | 2005-05-26 | Tissue repair |
GB0521491A GB0521491D0 (en) | 2005-10-21 | 2005-10-21 | Tissue repair |
GB0521491.1 | 2005-10-21 | ||
PCT/GB2006/001916 WO2006125991A1 (fr) | 2005-05-26 | 2006-05-25 | Reparation de tissus au moyen de fibroblastes dermiques allogenes |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2006/001916 A-371-Of-International WO2006125991A1 (fr) | 2005-05-26 | 2006-05-25 | Reparation de tissus au moyen de fibroblastes dermiques allogenes |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/791,177 Continuation US9271923B2 (en) | 2005-05-26 | 2013-03-08 | Tissue repair using allogeneic dermal fibroblasts |
Publications (1)
Publication Number | Publication Date |
---|---|
US20080199440A1 true US20080199440A1 (en) | 2008-08-21 |
Family
ID=36607531
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/915,514 Abandoned US20080199440A1 (en) | 2005-05-26 | 2006-05-25 | Tissue Repair Using Allogenic Dermal Fibroblasts |
US13/791,177 Expired - Fee Related US9271923B2 (en) | 2005-05-26 | 2013-03-08 | Tissue repair using allogeneic dermal fibroblasts |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/791,177 Expired - Fee Related US9271923B2 (en) | 2005-05-26 | 2013-03-08 | Tissue repair using allogeneic dermal fibroblasts |
Country Status (7)
Country | Link |
---|---|
US (2) | US20080199440A1 (fr) |
EP (1) | EP1885280A1 (fr) |
JP (1) | JP2008542252A (fr) |
AU (1) | AU2006251004C1 (fr) |
CA (1) | CA2609507C (fr) |
GB (1) | GB2426452B (fr) |
WO (1) | WO2006125991A1 (fr) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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US8532084B2 (en) | 2006-01-18 | 2013-09-10 | Huawei Technologies Co., Ltd. | Method and system for synchronization in communication system |
US11554142B2 (en) * | 2010-05-07 | 2023-01-17 | Castle Creek Biosciences, Llc | Dosage unit formulations of autologous dermal fibroblasts |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
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TR200602727A2 (tr) * | 2006-05-31 | 2007-12-24 | Tun� T�Ryak� Kemal | Cilt defektleri ve yaşlanması tedavisinde kullanılacak bir yöntem ve bir doku maddesi |
KR20070122315A (ko) * | 2006-06-26 | 2007-12-31 | (주) 에스바이오메딕스 | 자가 진피 세포 및 히알루론산을 함유하는 주사용 인체연조직 충전제 조성물 |
US8728819B2 (en) | 2006-08-29 | 2014-05-20 | Fibrocell Technologies, Inc. | Methods for culturing minimally-passaged fibroblasts and uses thereof |
GB0822246D0 (en) | 2008-12-05 | 2009-01-14 | Reneuron Ltd | Composition |
GB0902034D0 (en) | 2009-02-06 | 2009-03-11 | Reneuron Ltd | Method |
FR2948286B1 (fr) * | 2009-07-27 | 2011-08-26 | Jean-Noel Thorel | Composition injectable associant un agent de comblement et un milieu de croissance des fibroblastes |
EP2404993A1 (fr) * | 2010-07-09 | 2012-01-11 | Merz Pharma GmbH & Co. KGaA | Produit de remplissage à base d'alginate incluant des cellules eucaryotes |
JP2015510884A (ja) * | 2012-03-07 | 2015-04-13 | ファイブロセル テクノロジーズ, インコーポレイテッド | 局所的皮膚用製剤および皮膚の個人向けの処置方法 |
RU2014101757A (ru) * | 2014-01-21 | 2015-07-27 | Дауд Меджидович Шамов | Способ восстановления ткани |
GB2526542A (en) * | 2014-05-26 | 2015-12-02 | David Anthony Waghorn | Stem cell implanter and absorbable stem cell implant |
RU2578804C1 (ru) * | 2015-04-27 | 2016-03-27 | Екатерина Евгеньевна Фаустова | Способ омоложения организма пациента |
RU2617237C2 (ru) * | 2015-06-23 | 2017-04-24 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Северный государственный медицинский университет" Министерства здравоохранения Российской Федерации | Способ получения препаратов изолированных клеток дермы |
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-
2006
- 2006-05-25 AU AU2006251004A patent/AU2006251004C1/en not_active Ceased
- 2006-05-25 EP EP06743989A patent/EP1885280A1/fr not_active Withdrawn
- 2006-05-25 JP JP2008512917A patent/JP2008542252A/ja active Pending
- 2006-05-25 US US11/915,514 patent/US20080199440A1/en not_active Abandoned
- 2006-05-25 CA CA2609507A patent/CA2609507C/fr not_active Expired - Fee Related
- 2006-05-25 GB GB0610415A patent/GB2426452B/en not_active Expired - Fee Related
- 2006-05-25 WO PCT/GB2006/001916 patent/WO2006125991A1/fr active Application Filing
-
2013
- 2013-03-08 US US13/791,177 patent/US9271923B2/en not_active Expired - Fee Related
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US8897286B2 (en) | 2006-01-18 | 2014-11-25 | Huawei Technologies Co., Ltd. | Method and system for synchronization in communication system |
US9277568B2 (en) | 2006-01-18 | 2016-03-01 | Huawei Technologies Co., Ltd. | Method, apparatus and system for random access |
US10009928B2 (en) | 2006-01-18 | 2018-06-26 | Huawei Technologies Co., Ltd. | Method, apparatus and system for random access |
US10779330B2 (en) | 2006-01-18 | 2020-09-15 | Huawei Technologies Co., Ltd. | Method, apparatus and system for random access |
US11554142B2 (en) * | 2010-05-07 | 2023-01-17 | Castle Creek Biosciences, Llc | Dosage unit formulations of autologous dermal fibroblasts |
Also Published As
Publication number | Publication date |
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CA2609507A1 (fr) | 2006-11-30 |
JP2008542252A (ja) | 2008-11-27 |
AU2006251004A1 (en) | 2006-11-30 |
CA2609507C (fr) | 2014-10-21 |
US9271923B2 (en) | 2016-03-01 |
AU2006251004B2 (en) | 2012-12-06 |
GB0610415D0 (en) | 2006-07-05 |
EP1885280A1 (fr) | 2008-02-13 |
WO2006125991A1 (fr) | 2006-11-30 |
US20130224158A1 (en) | 2013-08-29 |
GB2426452B (en) | 2007-11-07 |
GB2426452A (en) | 2006-11-29 |
AU2006251004C1 (en) | 2013-05-23 |
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