US20080196437A1 - Apparatus for Shell Freezing a Liquid Content in a Container - Google Patents

Apparatus for Shell Freezing a Liquid Content in a Container Download PDF

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Publication number
US20080196437A1
US20080196437A1 US11/568,882 US56888205A US2008196437A1 US 20080196437 A1 US20080196437 A1 US 20080196437A1 US 56888205 A US56888205 A US 56888205A US 2008196437 A1 US2008196437 A1 US 2008196437A1
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US
United States
Prior art keywords
rollers
conveyor
length
containers
liquid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US11/568,882
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English (en)
Inventor
Jacques Thilly
Pierre-Jacques Van Roy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline Biologicals SA
GlaxoSmithKline LLC
Original Assignee
GlaxoSmithKline LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GlaxoSmithKline LLC filed Critical GlaxoSmithKline LLC
Assigned to GLAXOSMITHKLINE BIOLOGICALS SA reassignment GLAXOSMITHKLINE BIOLOGICALS SA ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: VAN ROY, PIERRE JACQUES, THILLY, JACQUES
Publication of US20080196437A1 publication Critical patent/US20080196437A1/en
Abandoned legal-status Critical Current

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Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D3/00—Devices using other cold materials; Devices using cold-storage bodies
    • F25D3/10—Devices using other cold materials; Devices using cold-storage bodies using liquefied gases, e.g. liquid air
    • F25D3/11—Devices using other cold materials; Devices using cold-storage bodies using liquefied gases, e.g. liquid air with conveyors carrying articles to be cooled through the cooling space
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00—Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
    • F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing

Definitions

  • the conveyor is constructed so that along the return length rollers are immersed into the cooling liquid with their rotation axis vertical. This orientation of the rollers can facilitate the use of a relatively deep but narrow trough of cooling liquid, which can help to reduce evaporation loss of the cooling liquid.
  • rollers rotate about a rotation axis parallel to the conveying direction and perpendicular to their conveying length, so that their rotation axis becomes aligned horizontally across the conveying direction as described above.
  • This may be achieved by mounting the rollers on the conveyor such that the rollers can pivot about an axis parallel to the conveying direction so that their rotation axis can pivot between the vertical and horizontal alignments.
  • rollers Whilst the rollers have their rotation axis other than aligned horizontally across the conveying direction the rollers need not rotate about their rotation axis, so that the containers e.g. vials in contact with them do not consequently spin. Preferably the rollers move in the conveying direction at a sufficient speed that all or the bulk of the content of the containers is still liquid by the time the rollers adopt their horizontal orientation.
  • FIG. 8 shows in more detail the overall construction of the conveyor.
  • FIGS. 1 , 2 and 3 shows an overall perspective schematic view of the architecture of an apparatus of this invention.
  • FIGS. 1 and 2 show a longitudinal section, cut in the conveying direction shown by the arrow, through the conveyor.
  • FIG. 3 shows a cross section through the conveyor cut across the conveying direction at line III-III of FIG. 1 .
  • FIGS. 4 and 6 show part sections cut across the conveying length at points IV-IV and VI-VI respectively.
  • Each roller 106 is integrally made with a spindle 107 extending in its rotation axis direction, and each mounting 105 comprises a bearing through which the spindles are rotatably threaded. These bearings are lubricant-free but have considerable slack to reduce the possibility of jamming.
  • a toothed pinion gear 108 which engages a rack 109 which extends alongside the conveying length 101 . Engagement of this rack 109 with pinion 108 causes pinion 108 , spindle 107 and roller 106 to rotate.
  • FIG. 4A shows the vial 1010 in a longitudinal section and shows the cylindrical body 1010 A and a cylindrical neck region 1010 B terminating at a mouth opening 1010 C, with an internal step 1010 D between the body 1010 A and the neck 1010 B, so that when the vial 1010 is arranged horizontally it can hold liquid content 1011 without it spilling out.
  • the trough 200 is double walled, having an outer wall 205 with a void 206 between the walls 204 , 205 , and cold nitrogen gas 203 evaporating from the liquid nitrogen 201 in the trough 200 flows over the inner wall and into this void 206 between the walls 202 , 204 , and an exhaust manifold 207 is provided to remove the gaseous nitrogen.
  • This double walled arrangement helps to insulate the trough 200 .
  • Trough 200 is supported by a conventional stand (not shown).
  • FIG. 2 shows the liquid content 1011 of the vials 1010 in three states: 1011 A in a liquid state with the vial 1010 vertical, 1011 B with the vial horizontal and spinning, with the liquid content 1011 B converting from a liquid to a frozen state as the vial 1010 moves in the conveying direction, and 1011 C in a frozen state with the vial 1010 again vertical.
  • FIG. 5 also shows the off-loading system 400 of the conveyor 100 .
  • Vials 1010 approach the downstream end 101 B of the conveyor 100 in their horizontal orientation i.e. as seen in FIG. 4B .
  • the mountings 105 pivot, e.g. under the action of cam or ramp surfaces (not shown) so that the vials 1010 rotate into the vertical orientation 1010 A as shown in FIG. 4B but with their content 1011 in a thin frozen layer around the walls of the vial 1010 .
  • Another guide rail 1013 analogous to that 1012 is located at the downstream end 101 B to support the vials 1010 whist in their vertical orientation.
  • FIG. 6 shows a part section cut across the return length 102 at points VI-VI.
  • the rollers 106 have pivoted into a vertical configuration analogous to FIG. 4B but inverted. In this configuration the rollers 106 are immersed in the liquid nitrogen 201 in trough 200 , and thereby cooled.
  • the rollers 106 in their vertical orientation at the downstream end 101 B travel around the guide wheel 104 they roll around the guide wheel 104 and enter the liquid nitrogen 201 in trough 200 .
  • FIG. 8 shows an overall perspective view of the conveyor 100 . It is seen how over most of the central part of the conveying length 101 the rollers 106 are oriented horizontally. It can clearly be seen how rollers 106 swing from a vertical orientation 1063 to a horizontal orientation 1061 . Rollers 106 are also clearly seen in their inverted orientation as shown in FIG. 6 on the return length 102 of the conveyor 100 .
  • FIG. 10 shows a more detailed plan view similar to FIG. 5 .
  • two motors 1018 , 1019 are shown used for driving the conveyor 100 and the star wheels 302 , 303 , 401 , 402 by appropriate gearing.
  • Two sets of star wheels 302 , 303 and 401 , 402 are respectively used at the on- and off-loading positions 300 , 400 .
  • Motors 1020 , 1021 , and 1022 vibrate the on-loading and receiving trays 301 , 403 , 404 .
  • Support wheels 103 (also seen in FIG. 8 ) are rotatably mounted at points along the conveyor 100 .

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Thermal Sciences (AREA)
  • Combustion & Propulsion (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Devices That Are Associated With Refrigeration Equipment (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Auxiliary Devices For And Details Of Packaging Control (AREA)
US11/568,882 2004-05-10 2005-05-09 Apparatus for Shell Freezing a Liquid Content in a Container Abandoned US20080196437A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0410382.6A GB0410382D0 (en) 2004-05-10 2004-05-10 Novel device
GB0410382.6 2004-05-10
PCT/EP2005/005124 WO2005108885A1 (en) 2004-05-10 2005-05-09 Apparatus for shell freezing a liquid content in a container

Publications (1)

Publication Number Publication Date
US20080196437A1 true US20080196437A1 (en) 2008-08-21

Family

ID=32526747

Family Applications (1)

Application Number Title Priority Date Filing Date
US11/568,882 Abandoned US20080196437A1 (en) 2004-05-10 2005-05-09 Apparatus for Shell Freezing a Liquid Content in a Container

Country Status (6)

Country Link
US (1) US20080196437A1 (ja)
EP (1) EP1759152A1 (ja)
JP (1) JP2007536495A (ja)
CA (1) CA2566014A1 (ja)
GB (1) GB0410382D0 (ja)
WO (1) WO2005108885A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050241331A1 (en) * 2004-04-22 2005-11-03 Linde Aktiengesellschaft Method and device for refrigerating and/or freezing articles

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2980262B1 (fr) * 2011-09-20 2019-11-22 Imv Technologies Procede de congelation d'une pluralite de tubes de conditionnement remplis chacun d'un volume predetermine de substance biologique et systeme pour la mise en œuvre d'un tel procede
FR2980261B1 (fr) 2011-09-20 2013-10-18 Imv Technologies Ensemble de congelation d'une pluralite de tubes de conditionnement chacun rempli d'un volume predetermine de substance biologique
CN111389653B (zh) * 2020-04-13 2021-06-08 林汇轩 一种mems传感器蘸胶装置

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1907649A (en) * 1930-06-04 1933-05-09 Paul W Petersen Process of quick-freezing
US2441730A (en) * 1944-05-30 1948-05-18 Us Director Of The Office Of S Method and means for preservation of blood plasma and the like by freezing and drying
US2494864A (en) * 1946-11-18 1950-01-17 Cal Grove Products Co Can cooling machine
US2655007A (en) * 1951-05-29 1953-10-13 Refrigeration Systems Inc Shell freezer and method of freezing liquids
US3241329A (en) * 1963-09-06 1966-03-22 Chemetron Corp Liquefied gas refrigeration system
US3623331A (en) * 1969-11-20 1971-11-30 Swift & Co Poultry chilling
US5467612A (en) * 1994-04-29 1995-11-21 Liquid Carbonic Corporation Freezing system for fragible food products
US5964043A (en) * 1995-03-18 1999-10-12 Glaxo Wellcome Inc. Freeze-drying process and apparatus
US6120828A (en) * 1998-08-14 2000-09-19 Howa Sangyo Co., Ltd. Method for freezing boiled rice in separate small-lump form
US6381967B1 (en) * 1998-06-17 2002-05-07 Randall H Craig Cryogenic freezing of liquids

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5775929A (en) * 1980-08-28 1982-05-12 Merck & Co Inc Freeze drying method
JPH0674085B2 (ja) * 1985-12-09 1994-09-21 東洋製罐株式会社 搬送方法及び搬送装置
JPH061142B2 (ja) * 1989-10-27 1994-01-05 共和真空技術株式会社 被凍結材料の凍結方法と容器内液材料の凍結装置
JPH076729B2 (ja) * 1991-01-25 1995-01-30 岩谷産業株式会社 薬液凍結装置

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1907649A (en) * 1930-06-04 1933-05-09 Paul W Petersen Process of quick-freezing
US2441730A (en) * 1944-05-30 1948-05-18 Us Director Of The Office Of S Method and means for preservation of blood plasma and the like by freezing and drying
US2494864A (en) * 1946-11-18 1950-01-17 Cal Grove Products Co Can cooling machine
US2655007A (en) * 1951-05-29 1953-10-13 Refrigeration Systems Inc Shell freezer and method of freezing liquids
US3241329A (en) * 1963-09-06 1966-03-22 Chemetron Corp Liquefied gas refrigeration system
US3623331A (en) * 1969-11-20 1971-11-30 Swift & Co Poultry chilling
US5467612A (en) * 1994-04-29 1995-11-21 Liquid Carbonic Corporation Freezing system for fragible food products
US5964043A (en) * 1995-03-18 1999-10-12 Glaxo Wellcome Inc. Freeze-drying process and apparatus
US6381967B1 (en) * 1998-06-17 2002-05-07 Randall H Craig Cryogenic freezing of liquids
US6120828A (en) * 1998-08-14 2000-09-19 Howa Sangyo Co., Ltd. Method for freezing boiled rice in separate small-lump form

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050241331A1 (en) * 2004-04-22 2005-11-03 Linde Aktiengesellschaft Method and device for refrigerating and/or freezing articles

Also Published As

Publication number Publication date
EP1759152A1 (en) 2007-03-07
CA2566014A1 (en) 2005-11-17
WO2005108885A1 (en) 2005-11-17
GB0410382D0 (en) 2004-06-16
JP2007536495A (ja) 2007-12-13

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AS Assignment

Owner name: GLAXOSMITHKLINE BIOLOGICALS SA, BELGIUM

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:THILLY, JACQUES;VAN ROY, PIERRE JACQUES;REEL/FRAME:020365/0131;SIGNING DATES FROM 20071221 TO 20071226

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION