US20080190516A1 - Method for Filing a Cavity with a Quantity of Particulate Material - Google Patents
Method for Filing a Cavity with a Quantity of Particulate Material Download PDFInfo
- Publication number
- US20080190516A1 US20080190516A1 US11/913,403 US91340306A US2008190516A1 US 20080190516 A1 US20080190516 A1 US 20080190516A1 US 91340306 A US91340306 A US 91340306A US 2008190516 A1 US2008190516 A1 US 2008190516A1
- Authority
- US
- United States
- Prior art keywords
- transfer device
- medicament
- pack
- chambers
- cavity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000000034 method Methods 0.000 title claims abstract description 34
- 239000011236 particulate material Substances 0.000 title abstract description 27
- 239000003814 drug Substances 0.000 claims description 111
- 239000000843 powder Substances 0.000 claims description 28
- 238000004140 cleaning Methods 0.000 claims description 5
- 238000007789 sealing Methods 0.000 claims description 5
- 238000000151 deposition Methods 0.000 claims 2
- 238000007790 scraping Methods 0.000 claims 2
- 238000012544 monitoring process Methods 0.000 description 4
- 229940079593 drug Drugs 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- 239000004411 aluminium Substances 0.000 description 2
- 239000011888 foil Substances 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000001680 brushing effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B7/00—Closing containers or receptacles after filling
- B65B7/16—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons
- B65B7/162—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons by feeding web material to securing means
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B1/00—Packaging fluent solid material, e.g. powders, granular or loose fibrous material, loose masses of small articles, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
- B65B1/30—Devices or methods for controlling or determining the quantity or quality or the material fed or filled
- B65B1/36—Devices or methods for controlling or determining the quantity or quality or the material fed or filled by volumetric devices or methods
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B37/00—Supplying or feeding fluent-solid, plastic, or liquid material, or loose masses of small articles, to be packaged
- B65B37/16—Separating measured quantities from supply
- B65B37/20—Separating measured quantities from supply by volume measurement
Definitions
- the present invention relates to a method and a device for filling a cavity with a quantity of particulate material, comprising the step of filling a chamber with its open side facing at least partially upwards with the quantity of particulate material.
- the method and device disclosed may be suitable for filling packs containing doses of powdered medicament, the doses being housed in cavities of the packs, which packs can be used in inhalation devices.
- Today supply and distribution of medicament is accomplished in many different ways. Within health care more and more is focused on the possibility to dose and distribute medicaments in the form of powder directly to the lungs of a user by means of a dispensing device, for example an inhalation device, to obtain an efficient and user friendly administration of the specific medicament. In most cases, some form of dosing process is used for preparing the dose to be inhaled.
- the doses of medicament are provided in packs having several cavities for housing a dose of medicament. The cavities filled with a dose is subsequently sealed by a sealing sheet, for example a foil of aluminium. These packs are loaded into a dispensing device, in which the toil above the cavity is penetrated and the dose of medicament is released for inhalation by the user.
- the packs containing the doses of medicament can be in the form of blister packs or injection moulded discs provided with blisters and cavities, respectively, for housing the powdered medicament, the packs can have various shapes, and the cavities can be distributed in various patterns.
- the method for filling said cavities must provide an accurate and changeable dosing into the cavities, to provide packs containing accurate doses of medicament of different sizes.
- EP 1 354 795 A2 discloses a method and apparatus for the metered transport of fine powders into receptacles.
- the apparatus is provided with a hopper having an opening.
- the hopper is adapted to receive fine powder.
- the apparatus comprises a vibrating element vibrating within the powder, and a rotatable member provided with a plurality of chambers aligned about its periphery.
- the rotatable member may be rotated to align the chambers with said opening to allow powder to be transferred from the hopper and into the chambers.
- the rotatable member is rotated 180° to a dispensing position where the chambers are aligned with said receptacles, and the receptacles are filled with the powder.
- U.S. Pat. No. 5,187,921 A describes a method and apparatus for filling a blind cavity with a quantity of powder, which comprises urging the cavity, with its open side facing a least partially downwards, into a reservoir of powder, withdrawing from the cavity having the quantity of powder therein while the open side continues to face at least partially downwards, and subsequently applying a lid to cover the cavity having the powder therein.
- WO 03/066437 A1 discloses a method and apparatus for introducing powder into a pocket having an open side, including orientating the pocket with the open side facing at least partially upward, providing the pocket with a volume of powder greater than that of the pocket, compressing the volume of the powder to a predetermined bulk density, and removing excess powder so as to leave the pocket full of powder with the predetermined bulk density.
- U.S. Pat. No. 6,035,905 A describes a method for introducing each of a plurality of doses of particulate material into a respective compartment of a container, the method comprising the steps of inserting a respective protuberance, preferably a conduit through which said particle material is introduced into said compartment, into each compartment so as to reduce the capacity thereof, and filling each compartment with said particulate material, with the respective protuberance inserted in said compartment, and removing said protuberance, wherein the volume of each dose of material is less than that of its respective compartment.
- An object of the present invention is to provide a method and device for filling at least one cavity with a quantity of particulate material, which can fill cavities or blisters arranged in any kind of pattern in a pack or disc, for example arbitrary and non-linear patterns, are uncomplicated and manage to fill cavities with particulate material to a low cost, can distribute an accurate dose of powder having a smaller volume than that of the cavity housing the dose, are flexible and easy to adapt to new patterns of cavities, and can simultaneously fill all cavities or blisters in a disc or pack, thereby providing a high production capacity.
- This method and device may be used to fill cavities or blisters arranged in any kind of pattern in a pack or disc, for example arbitrary and non-linear patterns.
- the cavities can be filled with an accurate dose of powder having a smaller volume than that of the cavity housing the dose. All cavities or blisters in a disc or pack can be tilled simultaneously thereby providing a high production capacity.
- Some embodiments may result in substantially no loss of excess formulation, and may provide a high operative safety and a small physical size of the device.
- Some embodiments may provide an uncomplicated filling and may manage to fill cavities with particulate material to a low cost.
- the chamber may be exchangeable to adapt to the size of the dose to be dosed in said cavity.
- the quantity of particulate material is emptied into the cavity by the force of gravity, but the release of material from the chamber can be enhanced by knocking or vibrating the chamber when emptying the quantity of particulate material into the cavity, or by subjecting the particulate material to additional forces in the form of pressurized gas or vibrations, for example by way of ultra-sonic waves.
- the device can be equipped with vibration means for vibrating the chamber when emptying the quantity of particulate material into the cavity, or other additional means for subjecting the particulate material to additional forces in the form of pressurized gas or vibrations, for example caused by ultra-sonic waves.
- Some embodiments may be suitable for fill quantities above one mg.
- the filling accuracy increases with the flow ability and the weight of the particulate material.
- some embodiments may be suitable for free flowing or moderately free flowing particulate material, e.g. carrier-based formulations.
- the filling method has been tested in a bench-top set-up, where 8 mg of a carrier-based formulation was manually scrape filled into 100 chambers. The filling accuracy was established to 2.4% RSD.
- the size and shape of the opening of the chamber may be equal to the opening of the cavity, or the opening of the chamber may be smaller than the opening of the cavity and enclosed by the boundary of the opening of the cavity, when the openings of the chamber and cavity are facing each other.
- the cavity may be detachably locked to the chamber before said rotation, and then detached from said chamber when the cavity is filled.
- the chamber may be filled by way of scrape filling, achieved by at least one rotating scraper.
- the chamber may be filled with a quantity of particulate material forming a volume which is smaller than the volume of the cavity.
- some embodiments may be used for particulate material comprising powdered medicament.
- the device may include locking means for detachably locking the cavity to the chamber before said rotation, and may include detaching means for detaching the cavity from the chamber when the cavity is filled.
- the filling means includes scraper means for scrape filling the chamber, and the scraper means may include at least one rotating scraper.
- the volume of the chamber may be smaller than the volume of the cavity.
- the cavity can be accurately and easily filled with a quantity of particulate material having a volume smaller than the volume of the cavity.
- the device may include at least one filling element provided with each chamber, and the device may be adapted for at least one cavity provided in a disc.
- the element may be interchangeable with other elements having chambers of others sizes and distributed in other patterns, to adapt to the other sizes of doses and to other patterns of the cavities.
- the filling element may include several chambers, the amount of which is the same as the amount of cavities, and the positions of the chambers corresponding to the positions of the cavities in the disc, whereby the opening of each chamber is facing an opening of a cavity when the filling element is locked to a disc.
- the device may include several filling elements.
- the guiding means may include a conveyor belt to which the element is attached.
- the device may be adapted for a particulate material comprising powdered medicament.
- some embodiments may provide a method for producing packs containing doses of medicament.
- Some embodiments also provide an apparatus for producing packs containing doses of medicament.
- FIG. 1 is a schematic top view of a circular drug disc provided with cavities in a circular pattern.
- FIG. 2 is a schematic top view of an embodiment of the filling element, and an embodiment of the scraper means, which filling element corresponds to the drug disc of FIG. 1 .
- FIG. 3 a - 3 h are schematic partial side views of a filling element applied to a disc having cavities, illustrating an embodiment of the method.
- FIG. 4 is a schematic side view of an embodiment of the device.
- FIG. 1 shows a top view of a circular drug disc 1 provided with several cavities 2 for housing powdered medicament.
- the cavities 2 are distributed in a circular pattern.
- This kind of disc 1 can for example be loaded into an inhalation device.
- FIG. 2 shows a top view of an embodiment of the filling element 3 , adapted to the disc of FIG. 1 .
- the filling element 3 is provided with several chambers 4 , the amount of which is the same as the amount of cavities in said disc.
- the positions of the chambers 4 correspond to the positions of the cavities in the disc, whereby the opening of each chamber 4 is facing an opening of a cavity when the filling element 3 is locked to the disc.
- FIG. 2 shows scraper means 5 for scrape filling the chambers 4 , the scraper means 5 comprising four rotating scrapers 6 .
- a dosing device (not shown) is arranged to dispense the powdered medicament on the surface of the filling element 3 .
- the filling element 3 is provided with a radial emptying slit 8 in which excess powder not filled into the chambers 4 is collected during the rotation of the rotating scrapers 6 , and can be reused in the subsequent filling of chambers.
- Means for disposal of excess powder may be through a slit or opening in proximity of the chambers.
- the slit may be radial, as shown in the figure, or coaxial inside of the chambers or coaxial outside of the chambers. Excess powder can also be disposed using suction, brushing or adhesive surfaces.
- FIGS. 3 a to 3 h show a disc having cavities and a filling element adapted to said disc, illustrating an embodiment of the method. Only two cavities and two chambers are shown in the Figures.
- FIG. 3 a shows two chambers 10 . 1 , 10 . 2 provided in a filling element 11 , the open side of each chamber 10 . 1 , 10 . 2 facing substantially upwards.
- the volume of each chamber is about 75-100% of the volume of the cavity to be filled, but the filling element 11 can be interchanged by a filling element with chambers having a different volume in order to adapt to the size of the dose wanted in the cavities.
- FIG. 3 b the whole volume of each chamber 10 . 1 , 10 .
- FIG. 3 c all chambers 10 . 1 , 10 . 2 are filled with a quantity 12 . 1 , 12 . 2 of powdered medicament and all excess powder has been removed.
- a disc 14 having several cavities 15 . 1 , 15 . 2 , the amount of which being the same as the amount of chambers 10 . 1 , 10 . 2 in said filling element 11 , and the positions of which corresponding to the positions of the chambers 10 . 1 , 10 .
- each cavity 15 . 1 , 15 . 2 in the filling element 11 is positioned on top of the filling element 11 , so that the opening of each cavity 15 . 1 , 15 . 2 is positioned opposite and in close proximity to the opening of a corresponding chamber 10 . 1 , 10 . 2 .
- the disc 14 is detachably locked to the filling element 11 .
- the interlocked filling element 11 and disc 14 have been rotated about 180°, whereby each chamber 10 . 1 , 10 . 2 has been rotated together with a corresponding cavity 15 . 1 , 15 . 2 , so that each cavity 15 . 1 , 15 . 2 is positioned with its open side facing substantially upwards and each chamber 10 . 1 , 10 .
- FIG. 3 f the quantities 12 . 1 , 12 . 2 of powdered medicament have and been emptied into each cavity 15 . 1 , 15 . 2 , whereby each chamber 10 . 1 , 10 . 2 is cleared from powder.
- FIG. 3 g the filling element 11 has been detached from the disc 14 , and the volume of each cavity 15 . 1 , 15 . 2 is filled to 75-100% by powdered medicament.
- the cavities 15 . 1 , 15 . 2 each filled with the quantity 12 . 1 , 12 . 2 of powdered medicament, are sealed by a sealing sheet 16 of aluminium.
- FIG. 4 shows a schematic side view of an embodiment of the device for filling cavities with a quantity of particulate material.
- the device comprises a conveyor belt 20 to which several filling elements 21 are attached.
- the filling elements 21 can have the same design as the filling element of FIG. 2 , and be adapted to fill cavities provided in discs having the same design as the disc of FIG. 1 .
- the device comprises filling means comprising a dosing device 22 , a first scraper means 23 , and a second scraper means 24 , each scraper means 23 , 24 comprising a plurality of scrapers 25 , 26 rotating around an axis 27 , 28 .
- the dosing device 22 is arranged to dispense a plurality of portions of powdered medicament onto the surface of the filling element 21 .
- the first scraper means 23 is arranged to provide a first scrape filling of all chambers, when each chamber has its open side facing substantially upwards, through rotation of its scrapers 25
- the second scraper means 24 is arranged to provide a second scrape filling of the chambers and also to remove excess powder into the emptying slit of the filling element 21 (see FIG. 2 ).
- the emptying slit is closed during the filling of the chambers and is only open during the action of the second scraper means 24 when excess powder is to be removed.
- the device comprises operating means 29 for positioning a disc 30 on top of the filling element 21 so that the opening of each cavity is positioned opposite and in close proximity to a corresponding opening of a chamber.
- Each filling element 21 is provided with locking means 37 for detachably locking the disc 30 to the filling element 21 , whereby the opening of each chamber is locked in position facing an opening of a cavity.
- the conveyor belt 20 to which each filling element 21 is attached is arranged to guide each filling element 21 between the different process steps and to rotate the interlocked filling element 21 and disc 30 approximately 180°, whereby the filled chamber is rotated together with the corresponding cavity, so that the cavity is positioned with its open side facing substantially upwards and the chamber is positioned with its open side facing substantially downwards, whereby the quantity of particulate material is emptied from the chambers of the filling element 21 into the corresponding cavities of the disc 30 .
- the device comprises detaching means 31 for detaching the disc from the filling element 21 when each cavity is filled.
- the device also comprises a first and second cleaning unit 32 , 33 arranged to clean the filling elements 21 after their chambers have been cleared from the powdered medicament, by means of pressurized air and suction. Further, the device is provided with a first and a second monitoring unit 34 , 35 .
- the first monitoring unit 34 is arranged to scan the chambers subsequent to the filling means 22 , 23 , 24 , to confirm complete filling
- the second monitoring unit 35 is arranged to scan the filling element 21 subsequent to the first and second cleaning unit 32 , 33 , to confirm complete cleaning of the filling element 21 .
- the device can optionally be provided with a third monitoring unit 36 arranged to confirm complete filling of the disc 30 .
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Quality & Reliability (AREA)
- Basic Packing Technique (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Supply Of Fluid Materials To The Packaging Location (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0501011 | 2005-05-02 | ||
SE0501011-1 | 2005-05-02 | ||
PCT/SE2006/000519 WO2006118526A1 (en) | 2005-05-02 | 2006-04-28 | A method for filling a cavity with a quantity of particulate material |
Publications (1)
Publication Number | Publication Date |
---|---|
US20080190516A1 true US20080190516A1 (en) | 2008-08-14 |
Family
ID=37308235
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/913,403 Abandoned US20080190516A1 (en) | 2005-05-02 | 2006-04-28 | Method for Filing a Cavity with a Quantity of Particulate Material |
Country Status (5)
Country | Link |
---|---|
US (1) | US20080190516A1 (de) |
EP (1) | EP1879798A4 (de) |
JP (1) | JP2008540263A (de) |
CN (1) | CN101171174A (de) |
WO (1) | WO2006118526A1 (de) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105292529A (zh) * | 2015-11-03 | 2016-02-03 | 重庆植恩药业有限公司 | 一种药品包装机械 |
US20160256354A1 (en) * | 2013-10-17 | 2016-09-08 | Zhejiang Huashili Machinery Co., Ltd. | Uniform-Distribution Filling Mechanism for Medicinal Powder |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20110139812A1 (en) * | 2007-08-24 | 2011-06-16 | Allan Dagsland | Method For Dosing And Providing Powder In A Powder Provider, Such A Powder Provider Device And An Apparatus For Producing Packs |
JP5468074B2 (ja) * | 2008-08-14 | 2014-04-09 | アストラゼネカ・アクチエボラーグ | キャビティに充填するための投薬デバイス及び投薬方法 |
CN102556375B (zh) * | 2012-02-27 | 2013-07-10 | 天津华津制药有限公司 | 用于粉针剂分装机的刮粉器 |
CN103029864A (zh) * | 2012-12-29 | 2013-04-10 | 梁爱英 | 一种粉状药配药机 |
CN105668021A (zh) * | 2016-03-15 | 2016-06-15 | 王丽 | 实现老年人智能自动取药提高服药准确性的方法 |
CN106314907B (zh) * | 2016-08-30 | 2018-09-11 | 嘉善金亿精密铸件有限公司 | 一种螺母的自动包装装置 |
CN113306753B (zh) * | 2021-05-07 | 2023-04-18 | 湖南华庭农业发展有限公司 | 一种散装面粉定量分装设备 |
CN115140354B (zh) * | 2022-09-05 | 2022-11-08 | 吉林大学 | 内科急救药物包装设备 |
Citations (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3295566A (en) * | 1964-12-14 | 1967-01-03 | Procter & Gamble | Filling machine for comminuted materials |
US3602401A (en) * | 1969-09-18 | 1971-08-31 | Riegel Paper Corp | Volumetric measuring and dispensing device with scraper |
US3718164A (en) * | 1971-11-17 | 1973-02-27 | Allied Chem | Powder feeding device |
US3762014A (en) * | 1966-05-23 | 1973-10-02 | Mallory & Co Inc P R | Apparatus for making capacitors |
US4398578A (en) * | 1981-04-16 | 1983-08-16 | The United States Of America As Represented By The Secretary Of Agriculture | Distributor for gravel and seeds |
US5187921A (en) * | 1990-09-04 | 1993-02-23 | Glaxo Group Limited | Method and apparatus for filling cavities |
US5287897A (en) * | 1991-01-15 | 1994-02-22 | Mg2 S.P.A. | Machine for dosing powdered pharmaceuticals |
US6035905A (en) * | 1995-11-17 | 2000-03-14 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Filling containers with particulate material |
US6581650B2 (en) * | 1996-04-26 | 2003-06-24 | Nektar Therapeutics | Powder filling systems, apparatus and methods |
US7069963B2 (en) * | 2004-02-09 | 2006-07-04 | Mederio Ag | Machine for volumetric filling of powders |
US7093625B2 (en) * | 2002-07-31 | 2006-08-22 | Philip Morris Usa Inc. | Dual station applicator wheels for filling cavities with metered amounts of particulate material |
US7426815B1 (en) * | 1999-05-21 | 2008-09-23 | Smithkline Beecham Corporation | Method and apparatus for loading a container with a product |
US7621300B2 (en) * | 2001-04-20 | 2009-11-24 | Glaxo Group Limited | Metering method for particulate material |
US7661447B2 (en) * | 2002-04-04 | 2010-02-16 | Glaxo Group Limited | Method and apparatus for loading a container with a product |
Family Cites Families (7)
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DE104827C (de) * | ||||
DE853575C (de) * | 1936-04-05 | 1952-10-27 | Jagenberg Werke Ag | Maschine zum Einfuellen abgeteilter Mengen pulverfoermigen oder kleinkoernigen Gutes |
FR2269064B1 (de) * | 1974-04-25 | 1976-10-15 | Commissariat Energie Atomique | |
SE8200262L (sv) * | 1982-01-19 | 1983-07-20 | Ingf Anders Westlund Ab | Anordning for utportionering av en forutbestemd mengd pulver- eller kornformigt material |
JP2936372B2 (ja) * | 1992-08-19 | 1999-08-23 | 三菱マテリアルクォーツ株式会社 | 粉体の移し替え装置 |
JPH09271996A (ja) * | 1996-04-05 | 1997-10-21 | Sankyo Co Ltd | タブレット自動成形装置 |
FR2768123B1 (fr) * | 1997-09-09 | 1999-11-26 | Soc Generale Pour Les Techniques Nouvelles Sgn | Procede et dispositif de conditionnement de produits, tel des poudres, notamment magnetiques |
-
2006
- 2006-04-28 JP JP2008509974A patent/JP2008540263A/ja active Pending
- 2006-04-28 WO PCT/SE2006/000519 patent/WO2006118526A1/en active Application Filing
- 2006-04-28 CN CNA2006800150623A patent/CN101171174A/zh active Pending
- 2006-04-28 US US11/913,403 patent/US20080190516A1/en not_active Abandoned
- 2006-04-28 EP EP06733374A patent/EP1879798A4/de not_active Withdrawn
Patent Citations (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3295566A (en) * | 1964-12-14 | 1967-01-03 | Procter & Gamble | Filling machine for comminuted materials |
US3762014A (en) * | 1966-05-23 | 1973-10-02 | Mallory & Co Inc P R | Apparatus for making capacitors |
US3602401A (en) * | 1969-09-18 | 1971-08-31 | Riegel Paper Corp | Volumetric measuring and dispensing device with scraper |
US3718164A (en) * | 1971-11-17 | 1973-02-27 | Allied Chem | Powder feeding device |
US4398578A (en) * | 1981-04-16 | 1983-08-16 | The United States Of America As Represented By The Secretary Of Agriculture | Distributor for gravel and seeds |
US5187921A (en) * | 1990-09-04 | 1993-02-23 | Glaxo Group Limited | Method and apparatus for filling cavities |
US5287897A (en) * | 1991-01-15 | 1994-02-22 | Mg2 S.P.A. | Machine for dosing powdered pharmaceuticals |
US6035905A (en) * | 1995-11-17 | 2000-03-14 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Filling containers with particulate material |
US6581650B2 (en) * | 1996-04-26 | 2003-06-24 | Nektar Therapeutics | Powder filling systems, apparatus and methods |
US7669617B2 (en) * | 1996-04-26 | 2010-03-02 | Novartis Pharma Ag | Powder filling systems, apparatus and methods |
US7426815B1 (en) * | 1999-05-21 | 2008-09-23 | Smithkline Beecham Corporation | Method and apparatus for loading a container with a product |
US7621300B2 (en) * | 2001-04-20 | 2009-11-24 | Glaxo Group Limited | Metering method for particulate material |
US7661447B2 (en) * | 2002-04-04 | 2010-02-16 | Glaxo Group Limited | Method and apparatus for loading a container with a product |
US7093625B2 (en) * | 2002-07-31 | 2006-08-22 | Philip Morris Usa Inc. | Dual station applicator wheels for filling cavities with metered amounts of particulate material |
US7069963B2 (en) * | 2004-02-09 | 2006-07-04 | Mederio Ag | Machine for volumetric filling of powders |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20160256354A1 (en) * | 2013-10-17 | 2016-09-08 | Zhejiang Huashili Machinery Co., Ltd. | Uniform-Distribution Filling Mechanism for Medicinal Powder |
US9999571B2 (en) * | 2013-10-17 | 2018-06-19 | Zhejiang Huashili Machinery Co., Ltd. | Uniform-distribution filling mechanism for medicinal powder |
CN105292529A (zh) * | 2015-11-03 | 2016-02-03 | 重庆植恩药业有限公司 | 一种药品包装机械 |
Also Published As
Publication number | Publication date |
---|---|
JP2008540263A (ja) | 2008-11-20 |
CN101171174A (zh) | 2008-04-30 |
EP1879798A4 (de) | 2010-07-28 |
EP1879798A1 (de) | 2008-01-23 |
WO2006118526A1 (en) | 2006-11-09 |
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