US20080073372A1 - Multicomponent Dispensing Device For Liquid And Powdery Materials - Google Patents

Multicomponent Dispensing Device For Liquid And Powdery Materials Download PDF

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Publication number
US20080073372A1
US20080073372A1 US11/793,978 US79397805A US2008073372A1 US 20080073372 A1 US20080073372 A1 US 20080073372A1 US 79397805 A US79397805 A US 79397805A US 2008073372 A1 US2008073372 A1 US 2008073372A1
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US
United States
Prior art keywords
chambers
dispensing device
dispensing
blister
blister base
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US11/793,978
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English (en)
Inventor
Wilhelm Keller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medmix Systems AG
Original Assignee
Medmix Systems AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medmix Systems AG filed Critical Medmix Systems AG
Assigned to MEDMIX SYSTEMS AG reassignment MEDMIX SYSTEMS AG ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: KELLER, WILHELM A.
Publication of US20080073372A1 publication Critical patent/US20080073372A1/en
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2093—Containers having several compartments for products to be mixed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C5/00—Filling or capping teeth
    • A61C5/60—Devices specially adapted for pressing or mixing capping or filling materials, e.g. amalgam presses
    • A61C5/62—Applicators, e.g. syringes or guns
    • A61C5/64—Applicators, e.g. syringes or guns for multi-component compositions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C—APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C17/00—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces
    • B05C17/005—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces for discharging material from a reservoir or container located in or on the hand tool through an outlet orifice by pressure without using surface contacting members like pads or brushes
    • B05C17/00503—Details of the outlet element
    • B05C17/00516—Shape or geometry of the outlet orifice or the outlet element
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C—APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C17/00—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces
    • B05C17/005—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces for discharging material from a reservoir or container located in or on the hand tool through an outlet orifice by pressure without using surface contacting members like pads or brushes
    • B05C17/00583—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces for discharging material from a reservoir or container located in or on the hand tool through an outlet orifice by pressure without using surface contacting members like pads or brushes the container for the material to be dispensed being deformable
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/0055—Containers or packages provided with a flexible bag or a deformable membrane or diaphragm for expelling the contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
    • A61J1/035—Blister-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2024—Separating means having peelable seals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C—APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C17/00—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces
    • B05C17/005—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces for discharging material from a reservoir or container located in or on the hand tool through an outlet orifice by pressure without using surface contacting members like pads or brushes
    • B05C17/00553—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces for discharging material from a reservoir or container located in or on the hand tool through an outlet orifice by pressure without using surface contacting members like pads or brushes with means allowing the stock of material to consist of at least two different components

Definitions

  • the present invention relates to a multicomponent dispensing device for liquid and powdery materials according to the preamble of claim 1 .
  • Such dispensing devices are based on the blister system and are e.g. described in EP-B-1 108 656.
  • Another dispensing device for dispensing a single dose of the components is described in WO98/01360.
  • Another object of the invention is to provide a dispensing device having chambers whose volume can be increased and which are suitable for receiving tablets or the like components. This object is attained by a dispensing device as defined in claim 19 .
  • FIG. 1 shows a first exemplary embodiment of a dispensing device according to the invention in a perspective view
  • FIG. 1A shows a variant of the embodiment of FIG. 1 .
  • FIGS. 2-4 schematically show the operations during the delivery of the materials
  • FIG. 5 shows another embodiment variant
  • FIG. 6 shows a dispensing device having a filling level adjusting device
  • FIG. 6A shows an enlarged detail of FIG. 6
  • FIG. 7 shows an embodiment variant having an integrated mixer
  • FIG. 7A shows an enlarged detail of FIG. 7 .
  • FIGS. 8-10 show another embodiment variant in a perspective view, in a sectional view, and in the closed position
  • FIGS. 11-14 show further embodiment variants
  • FIG. 15 shows a variant of a chamber surface in a sectional view according to line XV-XV in FIG. 14 ,
  • FIG. 16 shows another variant of the blister part having a tablet container in a sectional view according to line XVI-XVI in FIG. 17 ,
  • FIG. 17 shows the dispensing device of FIG. 16 from above
  • FIG. 18 shows another design of the blister base and of the dispensing members
  • FIG. 19 shows a perspective view of an exemplary embodiment having extensible chambers.
  • FIG. 1 illustrates a first embodiment variant of a dispensing device 1 comprising a film portion, hereinafter called blister part 2 , that has four chambers 3 , 4 and 5 , 6 and is arranged on a blister base 7 in such a manner that the chambers 3 , 4 and 5 , 6 that are interconnected by channels 8 and 9 are sealed by sutures 8 S and 9 S.
  • Chambers 3 and 5 nearer to the delivery end have respective channels 10 and 11 with outlet sutures 10 S and 11 S that lead to a static mixer 12 .
  • the channels between the chambers or the outlet may also be sealed or closed, or the two layers—the blister part and the blister base—connected to one another by other techniques.
  • the sutures or closures are of such a nature that they yield when a pressure is applied to the chambers so that the content of one chamber may be transferred to the other chamber. Generally, this is the case due to the fact that the sutures separate from the blister base.
  • detachable welded or adhesive joints in the channels may be provided. In the following, seams of all types will be designated as sutures in the channels that detach under pressure to create a passage.
  • sutures 8 S and 9 S are detached from the base and the content of chambers 4 and 6 is transferred to chambers 3 and 5 .
  • the already premixed substances are transferred via the detached outlet sutures 10 S and 11 S to mixer 12 .
  • blister base 7 has two adjacent dispensing members 13 and 14 that may also be injection-molded like the blister base and are connected to the latter, respectively to first dispensing member 13 , by hinges 15 and 16 .
  • First dispensing member 13 has a locking knob 17 that fits into a corresponding opening 18 in blister part 2 and blister base 7 .
  • FIGS. 2 to 4 illustrate the distinct dispensing steps, in which the two dispensing members 13 and 14 are first folded in FIG. 2 around hinge 15 and hinge 16 , then first dispensing member 13 is pressed on the two chambers 4 and 6 at the rear with respect to the mixer, whereby the components from these chambers are transferred via the now yielding sutures to forward chambers 3 and 5 and locking knob 17 engages, whereupon second dispensing member 14 is folded down over hinge 16 in order to press the two mixed substances from chambers 3 and 5 into and through the mixer via outlet sutures 10 S and 11 S that are yielding too.
  • the dispensing members may be folded over and pressed down either by hand or by means of a dispensing appliance that is suitably designed for receiving the dispensing device and folding and pressing down the dispensing members.
  • a dispensing appliance that acts upon the chambers directly and consecutively.
  • FIG. 1A illustrates an embodiment variant of chambers 20 , 21 and 22 , 23 , respectively, in which these chambers taper toward the outlet end in order to be dispensed as uniformly and completely as possible.
  • FIG. 5 it is shown exemplarily that the chambers may have unequal dimensions, chambers 24 and 25 of blister part 28 being smaller than the previously illustrated ones and also smaller than the other chambers 26 and 27 , and may additionally have a different shape.
  • the remaining parts of this dispensing device are the same as according to FIG. 1 .
  • a dispensing device 29 is provided with a filling level adjusting device 30 as it is e.g. described in WO2004/110854 to the applicant of the present invention.
  • a filling level adjusting device 30 as it is e.g. described in WO2004/110854 to the applicant of the present invention.
  • FIG. 6 and the enlarged detail view 6 A only some essential elements of the device are described while the remaining parts may be designed as before.
  • Blister part 31 with chambers 32 and 33 , channels 34 and 35 with sutures 34 S and 35 S, blister base 7 , and the two dispensing members 13 and 14 are depicted while FIG. 6 , in contrast to FIG. 1 , shows a view from below, i.e. on blister base 7 .
  • the blister base includes an outlet section 43 with outlets 43 A and 43 B.
  • FIG. 6A illustrates filling level adjusting device 30 with the two leveling chambers 36 and 37 as well as filter 38 and inlet section 30 E as described in the cited PCT application to the applicant of the present invention.
  • the leveling device allows to ensure that enclosed air may escape and possibly existing filling level differences are eliminated before a mixer is attached. At first, dispensing takes place until both components are visible inside the leveling chambers, whereupon the filling level adjusting device is withdrawn and a mixer can be mounted.
  • the mixer inlet section and the outlet section of the dispensing device may be designed such that the mixer is attachable removably.
  • blister base 45 of device 44 for each outlet channel 10 and 11 , respectively 35 , blister base 45 of device 44 according to FIGS. 7 and 7 A comprises a hydrophobic filter 46 that is mounted in an opening.
  • the hydrophobic filter allows evacuating the air contained in the system prior to dispensing, the components flowing around the filter as in a bypass after the channel sutures have again been detached.
  • the blister chambers can easily be filled after the blister part has been connected to the base.
  • device 47 comprises a blister base 48 having four filling apertures 49 A-D, i.e. one filling aperture for each chamber.
  • the chambers are filled via filling apertures 49 A-D and closed by means of closures 51 A-D that are attached to straps 52 A-D, as appears in FIG. 10 .
  • closures 51 A-D that are attached to straps 52 A-D, as appears in FIG. 10 .
  • FIGS. 11 to 13 illustrate a small fraction of the large diversity of possible variations.
  • dispensing device 53 has two adjacent chambers 55 and 56 requiring only one dispensing member 54 in order to dispense the material from the two chambers 55 and 56 .
  • the chambers are arranged in two rows, one row comprising two or three adjacent chambers, respectively, and two rows being arranged one after the other with respect to the outlet, thereby forming two or three columns. It is apparent that both the number of chambers in a row and the number of chambers in a column may vary, i.e. may be greater than three or two, respectively.
  • Each row requires a dispensing member that is connected to another dispensing member or to the blister base by a hinge.
  • Dispensing devices 57 and 59 according to FIG. 12 or 13 allow dispensing in analogy to the device according to FIG. 1 , the components from the rearward chambers being transferred to the forward chambers and then completely dispensed via channels 58 A, 58 B, 58 C with outlet sutures 58 S through the mixer.
  • FIGS. 12 and 13 two locking knobs 17 and 17 A are depicted that are pluggable into openings 18 and 18 A.
  • FIG. 14 illustrates that mixer 60 or its enclosure, respectively, can be formed integrally with blister base 61 of device 62 .
  • the remaining elements can be realized according to FIG. 1, 13 , or any of the other figures.
  • chambers 55 and 56 of FIG. 11 ensures a more uniform delivery of the substances.
  • FIG. 19 Another volume enlargement is illustrated in FIG. 19 where blister part 70 of dispensing device 69 has chambers 72 and 74 located at the rear with respect to its outlet as well as two forward chambers 71 and 73 of blister part 70 that are attached to blister base 7 .
  • Forward chambers 71 and 73 have respective annular zones 75 , 76 whose inner sides are less solidly sealed, welded or glued to the blister base, as in the case of the sutures, such that the inner sides of the zones are detached when the content of the rearward chambers is transferred to the forward chambers, thereby allowing a volume enlargement of the forward chambers.
  • the width of the annular zone depends on the desired volume enlargement.
  • FIGS. 16 and 17 another variant of blister part 82 is illustrated where forward chamber(s) 80 is/are provided with a compartment 78 that allows introducing a tablet 79 , e.g. in the form of a lyophilisate, that dissolves in a liquid from the rearward chamber.
  • the compartment in the chamber may be shaped to receive the tablet but not sealed so as to prevent that the inflowing liquid may reach the tablet.
  • the contour of the compartment may be connected to the blister base in order to seal the compartment.
  • the contour of the compartment should be connected to the base in such a manner that it is detached in the same way as closed channels 83 between the chambers and 84 between chambers 80 and the outlet when the liquid enters, and releases the tablet.
  • a dispensing device having chambers whose volume increases when a liquid enters, and/or at least one integrated tablet compartment, is also advantageous without an associated mixer.
  • blister base 66 as well as the dispensing member, respectively dispensing members 67 and 68 of dispensing device 65 , may be provided with impressions 63 and 64 serving as finger rests for an optimum position of the fingers.
  • the described devices are advantageous particularly for single dose applications in medicine, but they may also be used e.g. in dental technique or in industrial applications where only small amounts e.g. of an adhesive are required. This is particularly also the case in systems whose components are not long term stable and have to be premixed or dissolved only shortly before they can be mixed and dispensed. Furthermore, all applications have in common that no closure stopper is required, not even if a mixer is used.

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  • Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dentistry (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Geometry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Coating Apparatus (AREA)
  • Surgical Instruments (AREA)
US11/793,978 2004-12-30 2005-12-20 Multicomponent Dispensing Device For Liquid And Powdery Materials Abandoned US20080073372A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH20042168/04 2004-12-30
CH21682004 2004-12-30
PCT/CH2005/000765 WO2006069460A2 (de) 2004-12-30 2005-12-20 Mehrkomponenten-austragvorrichtung für flüssige und pulverförmige stoffe

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US20080073372A1 true US20080073372A1 (en) 2008-03-27

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US11/793,978 Abandoned US20080073372A1 (en) 2004-12-30 2005-12-20 Multicomponent Dispensing Device For Liquid And Powdery Materials

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Country Link
US (1) US20080073372A1 (de)
EP (1) EP1833739A2 (de)
JP (1) JP2008526623A (de)
CN (1) CN101094795A (de)
WO (1) WO2006069460A2 (de)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011026050A3 (en) * 2009-08-30 2011-07-28 Aktivpak, Inc. Dispensing device along with method for dispensing product
US8662349B2 (en) * 2009-08-30 2014-03-04 Aktivpak, Inc. Dispensing device incorporating frangible section, along with dispensing method
WO2015082894A1 (en) * 2013-12-04 2015-06-11 Team Consulting Limited A method and apparatus for manufacturing a container of pressurised fluid
US20190001368A1 (en) * 2016-02-18 2019-01-03 Henkel Ag & Co.Kgaa Device for applying adhesive and/or Sealant
US10231846B2 (en) 2016-08-19 2019-03-19 Stryker European Holdings I, Llc Bone graft delivery loading assembly
US20190166974A1 (en) * 2017-12-05 2019-06-06 Mark Davidov Disposable Portable Pocket Fluid/Floss Dispenser
AU2017254828B2 (en) * 2012-06-26 2019-07-18 Becton, Dickinson And Company Clip syringe
US10369288B2 (en) * 2015-03-15 2019-08-06 Norimoto Okabe Sealing container
US20200037728A1 (en) * 2018-08-01 2020-02-06 Mark Davidov Disposable portable pocket fluid/floss dispenser
WO2020251431A1 (en) * 2019-06-11 2020-12-17 Miltech Ab Method and apparatus for storage of fluid bio-samples in a package
WO2021068026A1 (en) * 2019-10-07 2021-04-15 Sands Innovations Ltd A container
US20210162139A1 (en) * 2012-06-26 2021-06-03 Becton, Dickinson And Company Single Use Delivery Device Having a Primer Element
US11278501B2 (en) 2018-10-15 2022-03-22 Aprecia Pharmaceuticals LLC Method and system for forming a dosage form within a packaging
WO2022208318A1 (en) * 2021-03-28 2022-10-06 Koska Family Limited Systems and methods for blow-fill-seal (bfs) assisted dispensing and disablement
US11759572B2 (en) 2011-01-17 2023-09-19 Aktivax, Inc. Aseptic cartridge and dispenser arrangement

Families Citing this family (6)

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US7669597B2 (en) * 2007-05-16 2010-03-02 Mystic Pharmaceuticals, Inc. Combination unit dose dispensing containers
AU2011228996B2 (en) * 2010-03-19 2015-01-29 Lophius Biosciences Gmbh In vitro process for the quick determination of a patient's status relating to infection with Mycobacterium tuberculosis
DE102010042740A1 (de) * 2010-10-21 2012-04-26 Ing. Erich Pfeiffer Gmbh Austragvorrichtung für Medien
CN103429287A (zh) * 2011-01-17 2013-12-04 阿克蒂夫帕克股份有限公司 无菌盒和配药器装置
ES2423909B1 (es) * 2012-03-21 2014-09-29 Genoveva Serra Caselles Depósito desechable con dosificador de producto
JP2014104979A (ja) * 2012-11-22 2014-06-09 Takeuchi Press Ind Co Ltd チューブ容器絞り出し器具

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US5114240A (en) * 1989-05-12 1992-05-19 Wolff & Kaaber A/S Method and a device for preparing a mixture of a solid and a liquid component
US5413253A (en) * 1993-12-06 1995-05-09 Coltene/Whaledent, Inc. Static mixer
US5890625A (en) * 1997-07-01 1999-04-06 L'oreal Device for the fractional emptying of a tube
US6019251A (en) * 1996-11-29 2000-02-01 Denki Kagaku Kogyo Kabushiki Kaisha Extrusion equipment for two-part reactive curing materials and coating equipment using the same
US6264065B1 (en) * 1996-07-05 2001-07-24 Valois S.A. Device for biphasic dispensing of a single dose
US20040065679A1 (en) * 2000-11-13 2004-04-08 Marc Peuker Device for storing and dispensing flowable compositions
US20040084554A1 (en) * 2002-10-24 2004-05-06 Valois Sas Fluid dispenser

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DE29921427U1 (de) * 1999-12-06 2000-02-10 Rpc Bramlage Gmbh Mehrkomponenten-Behälter zur Aufbewahrung und zum Ausbringen von flüssigen bis pastösen Stoffen
WO2004100854A2 (de) * 2003-05-15 2004-11-25 Mixpac Systems Ag Ausgleichvorrichtung für eine mehrkomponenten-austragvorrichtung

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US5114240A (en) * 1989-05-12 1992-05-19 Wolff & Kaaber A/S Method and a device for preparing a mixture of a solid and a liquid component
US5413253A (en) * 1993-12-06 1995-05-09 Coltene/Whaledent, Inc. Static mixer
US6264065B1 (en) * 1996-07-05 2001-07-24 Valois S.A. Device for biphasic dispensing of a single dose
US6019251A (en) * 1996-11-29 2000-02-01 Denki Kagaku Kogyo Kabushiki Kaisha Extrusion equipment for two-part reactive curing materials and coating equipment using the same
US5890625A (en) * 1997-07-01 1999-04-06 L'oreal Device for the fractional emptying of a tube
US20040065679A1 (en) * 2000-11-13 2004-04-08 Marc Peuker Device for storing and dispensing flowable compositions
US20040084554A1 (en) * 2002-10-24 2004-05-06 Valois Sas Fluid dispenser

Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2470444A2 (de) * 2009-08-30 2012-07-04 Aktivpak, Inc. Abgabevorrichtung sowie verfahren zur abgabe eines produkts
US20120241465A1 (en) * 2009-08-30 2012-09-27 Aktivpak, Inc. Dispensing device along with method for dispensing product
CN102712408A (zh) * 2009-08-30 2012-10-03 阿克蒂弗派克股份有限公司 用于分配产品的分配装置和方法
EP2470444A4 (de) * 2009-08-30 2013-03-27 Aktivpak Inc Abgabevorrichtung sowie verfahren zur abgabe eines produkts
US8662349B2 (en) * 2009-08-30 2014-03-04 Aktivpak, Inc. Dispensing device incorporating frangible section, along with dispensing method
WO2011026050A3 (en) * 2009-08-30 2011-07-28 Aktivpak, Inc. Dispensing device along with method for dispensing product
US11759572B2 (en) 2011-01-17 2023-09-19 Aktivax, Inc. Aseptic cartridge and dispenser arrangement
US11865322B2 (en) * 2012-06-26 2024-01-09 Becton, Dickinson And Company Single use delivery device having a primer element
US20210162139A1 (en) * 2012-06-26 2021-06-03 Becton, Dickinson And Company Single Use Delivery Device Having a Primer Element
AU2017254828B2 (en) * 2012-06-26 2019-07-18 Becton, Dickinson And Company Clip syringe
US11534551B2 (en) 2012-06-26 2022-12-27 Becton, Dickinson And Company Clip syringe
WO2015082894A1 (en) * 2013-12-04 2015-06-11 Team Consulting Limited A method and apparatus for manufacturing a container of pressurised fluid
US10369288B2 (en) * 2015-03-15 2019-08-06 Norimoto Okabe Sealing container
US20190290853A1 (en) * 2015-03-15 2019-09-26 Norimoto Okabe Sealing container
US11554219B2 (en) * 2015-03-15 2023-01-17 Norimoto Okabe Sealing container
US20190001368A1 (en) * 2016-02-18 2019-01-03 Henkel Ag & Co.Kgaa Device for applying adhesive and/or Sealant
US11383265B2 (en) * 2016-02-18 2022-07-12 Henkel Ag & Co. Kgaa Device for applying adhesive and/or sealant
US10857001B2 (en) 2016-08-19 2020-12-08 Stryker European Holdings I, Llc Bone graft delivery loading assembly
US11666456B2 (en) 2016-08-19 2023-06-06 Stryker European Operations Holdings Llc Bone graft delivery loading assembly
US10231846B2 (en) 2016-08-19 2019-03-19 Stryker European Holdings I, Llc Bone graft delivery loading assembly
US20190166974A1 (en) * 2017-12-05 2019-06-06 Mark Davidov Disposable Portable Pocket Fluid/Floss Dispenser
US11206910B2 (en) * 2018-08-01 2021-12-28 Mark Davidov Disposable portable pocket fluid/floss dispenser
US20200037728A1 (en) * 2018-08-01 2020-02-06 Mark Davidov Disposable portable pocket fluid/floss dispenser
US11278501B2 (en) 2018-10-15 2022-03-22 Aprecia Pharmaceuticals LLC Method and system for forming a dosage form within a packaging
WO2020251431A1 (en) * 2019-06-11 2020-12-17 Miltech Ab Method and apparatus for storage of fluid bio-samples in a package
WO2021068026A1 (en) * 2019-10-07 2021-04-15 Sands Innovations Ltd A container
CN114787048A (zh) * 2019-10-07 2022-07-22 桑德斯创新有限公司 容器
WO2022208318A1 (en) * 2021-03-28 2022-10-06 Koska Family Limited Systems and methods for blow-fill-seal (bfs) assisted dispensing and disablement

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EP1833739A2 (de) 2007-09-19
JP2008526623A (ja) 2008-07-24
WO2006069460A2 (de) 2006-07-06
WO2006069460A3 (de) 2006-10-12
CN101094795A (zh) 2007-12-26

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