US20070217932A1 - Method and system for providing adjustable compression force on a tube in a peristaltic pump - Google Patents

Method and system for providing adjustable compression force on a tube in a peristaltic pump Download PDF

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Publication number
US20070217932A1
US20070217932A1 US11/612,011 US61201106A US2007217932A1 US 20070217932 A1 US20070217932 A1 US 20070217932A1 US 61201106 A US61201106 A US 61201106A US 2007217932 A1 US2007217932 A1 US 2007217932A1
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US
United States
Prior art keywords
cassette
cam
edge
selector switch
position selector
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US11/612,011
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English (en)
Inventor
Claude Voyeux
Mustapha Mazouzi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gilson SAS
Original Assignee
Gilson SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilson SAS filed Critical Gilson SAS
Assigned to GILSON S.A.S. reassignment GILSON S.A.S. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: VOYEUX, CLAUDE
Publication of US20070217932A1 publication Critical patent/US20070217932A1/en
Abandoned legal-status Critical Current

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Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04C—ROTARY-PISTON, OR OSCILLATING-PISTON, POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; ROTARY-PISTON, OR OSCILLATING-PISTON, POSITIVE-DISPLACEMENT PUMPS
    • F04C5/00—Rotary-piston machines or pumps with the working-chamber walls at least partly resiliently deformable
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/12—Machines, pumps, or pumping installations having flexible working members having peristaltic action
    • F04B43/1253—Machines, pumps, or pumping installations having flexible working members having peristaltic action by using two or more rollers as squeezing elements, the rollers moving on an arc of a circle during squeezing
    • F04B43/1284—Means for pushing the backing-plate against the tubular flexible member
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/12—Machines, pumps, or pumping installations having flexible working members having peristaltic action
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/12—Machines, pumps, or pumping installations having flexible working members having peristaltic action
    • F04B43/1253—Machines, pumps, or pumping installations having flexible working members having peristaltic action by using two or more rollers as squeezing elements, the rollers moving on an arc of a circle during squeezing

Definitions

  • the field of the disclosure relates generally to peristaltic pumps. More specifically, the disclosure relates to cassettes that provide an adjustable compression force on a tube used in a peristaltic pump.
  • Peristaltic pumps have been known for many years, and are commonly used for medical and research purposes. Peristaltic pumps move a liquid through a tube without any part of the pump ever touching the liquid. As a result, it is possible to pump liquids, such as blood, which are sensitive to external contamination. Typically, a pump comprises rotating rollers that compress a part of the flexible tube as they move, which propels the liquid through the tube.
  • the flexible tube must withstand the compressive force while remaining absolutely leak proof.
  • the pump in the aforesaid document includes removable cassettes that each include a tube and a sliding movable cam that pushes the tube against the rollers to ensure good contact between tube and rollers.
  • the pump includes means to modulate the compressive force exerted by the cam on the tube. These means include two wedges which move inside the cassette in order to adjust the position of the cam relative to the tube. Each wedge is connected with the threaded part of a rod whose rotation can be externally controlled with a knob.
  • a method and a system for adjusting a position of a cam in a peristaltic pump is provided in an exemplary embodiment.
  • the position of the cam is easily and quickly moved even over a large range.
  • the compression force on the tube placed in the peristaltic pump is modified to accommodate different size tubes and different types of fluid flowing through the tube by the action of the pump.
  • a cassette for use in a peristaltic pump includes, but is not limited to, a cassette frame a cam, a cam position selector switch, and a biasing member.
  • the cassette frame mounts to the peristaltic pump.
  • the biasing member mounts to the cam and to the cassette frame and operably couples with the cam position selector switch so that movement of the cam position selector switch adjusts a position of the cam relative to the cassette frame.
  • a peristaltic pump includes, but is not limited to, a pump frame, a plurality of rollers configured to mount to the pump frame, an actuator operably coupled to move the plurality of rollers, and a cassette.
  • the cassette includes, but is not limited to, a cassette frame, a cam, a cam position selector switch, and a biasing member.
  • the cassette frame mounts to the pump frame and receives a tube.
  • the cam is positioned to compress the received tube against the plurality of rollers.
  • the biasing member mounts to the cam and to the cassette frame and operably couples with the cam position selector switch so that movement of the cam position selector switch adjusts a position of the cam relative to the cassette frame.
  • a method of adjusting a position of a cam in a peristaltic pump is provided.
  • a cassette is mounted to the peristaltic pump.
  • the cassette includes, but is not limited to, a cassette frame, a cam, a cam position selector switch, and a biasing member.
  • the biasing member mounts to the cam and to the cassette frame and operably couples with the cam position selector switch. Moving the cam position selector switch in a first direction releases the cam position selector switch from the cassette frame. Moving the cam position selector switch in a second direction after releasing the cam position selector switch from the cassette frame adjusts a position of the cam relative to the cassette frame. The second direction is approximately perpendicular to the first direction.
  • FIG. 1 is a perspective view of a peristaltic pump head with a cassette in a position to be installed onto the pump in accordance with an exemplary embodiment.
  • FIG. 2 is a perspective view of the peristaltic pump head of FIG. 1 with the cassette installed on the pump in accordance with an exemplary embodiment.
  • FIG. 3 is a front cross sectional view of the pump head of FIG. 2 with the cassette in accordance with an exemplary embodiment.
  • FIG. 4 is a front view of the cassette of FIG. 1 with some hidden parts illustrated with dashed lines in accordance with an exemplary embodiment.
  • FIG. 5 is a front perspective view of the cassette of FIG. 1 in accordance with an exemplary embodiment.
  • a peristaltic pump head 2 of a peristaltic pump is shown in accordance with an exemplary embodiment.
  • the peristaltic pump may include peristaltic pump head 2 and an actuator.
  • Peristaltic pump head 2 may include a crankcase 4 , a frame 5 , a plurality of rollers 8 , and a cassette 18 .
  • Frame 5 may include a center support 10 , a front wall 12 , a back wall 14 , and two braces 20 .
  • Crankcase 4 mounts to front wall 12 and includes an axis of symmetry 6 .
  • the term “mount” includes join, unite, connect, associate, insert, hang, hold, affix, attach, fasten, bind, paste, secure, bolt, screw, rivet, solder, weld, and other like terms.
  • the plurality of rollers 8 includes eight rollers symmetrically arranged around the axis of symmetry 6 .
  • the rollers are mounted in a rotating fashion on central support 10 .
  • each roller of the plurality of rollers 8 has a spherical shape and rotates about an axis parallel to the axis of symmetry 6 .
  • Central support 10 rotates around the axis of symmetry 6 .
  • the actuator is operably coupled to rotate the plurality of rollers 8 .
  • the actuator may include a rotor connected to the plurality of rollers through a shaft 11 as known to those skilled in the art.
  • the actuator may be any device as known to those skilled in the art for causing rotation of the plurality of rollers.
  • Exemplary actuators include an electric motor, a servo, stepper, or piezo motor, a pneumatic actuator, a gas motor, etc.
  • Front wall 12 and back wall 14 define between them a housing 16 sized to accommodate one or more cassettes 18 .
  • Front wall 12 and back wall 14 are linked together by the two braces 20 which extend parallel to the axis of symmetry 6 , and act as a support and locking mechanism for cassette 18 .
  • cassette 18 is shown released from the two braces 20 .
  • cassette 18 is shown mounted to the two braces 20 for use with the peristaltic pump.
  • Cassette 18 may or may not be removable from the peristaltic pump in alternative embodiments.
  • a plurality of cassettes 18 can be held in housing 16 as indicated in FIG. 2 , side by side, parallel to one another, and/or in contact with each other.
  • cassette 18 extends parallel to front wall 12 and back wall 14 in a plane, which is perpendicular to the axis of symmetry 6 .
  • cassette 18 includes a cassette frame 22 .
  • cassette frame 22 has essentially an inverted U shape formed by a front wall 36 and a back wall (not shown) with a frame edge 26 extending between front wall 36 and the back wall.
  • a cavity 30 (shown with reference to FIG. 4 ) is formed between front wall 36 and the back wall.
  • the inverted U shape of cassette frame 22 formed by front wall 36 and the back wall includes legs 28 which extend from a top brace 29 .
  • Cassette frame 22 may include notches 25 located near the lower ends of legs 28 opposite top brace 29 .
  • Cassette 18 mounts and locks onto peristaltic pump head 2 at the ends of legs 28 adjacent notches 25 .
  • a hook 31 extends from at least one of the legs 28 and mounts to at least one of the braces 20 of frame 5 .
  • a peripheral edge 61 in frame edge 26 defines a portion of a slot 53 within which a knob 60 is configured to move.
  • Cassette 18 includes a cam 32 accommodated in cavity 30 .
  • Cam 32 has an essentially flat rectangular shape with a saddle-shaped hollow formed by a lower edge 34 designed to face the plurality of rollers 8 .
  • Front wall 36 and the back wall partially cover each side of cam 32 .
  • FIG. 3 a front cross sectional view of cassette 18 mounted to frame 5 is shown in accordance with an exemplary embodiment.
  • a flexible tube 24 is mounted to cassette frame 22 in a removable manner.
  • flexible tube 24 is held in notches 25 .
  • Tube 24 rests against lower edge 34 of cam 32 .
  • the part of tube 24 resting against lower edge 34 extends between the parts of tube 24 housed in notches 25 .
  • Cassette 18 includes a biasing member 38 .
  • biasing member 38 is a blade spring.
  • Cassette 18 includes a cam position selector switch 56 .
  • cam position selector switch 56 includes a first edge 55 , a second edge 62 , and knob 60 .
  • First edge 55 includes a plurality of ridges. The plurality of ridges may have a scalloped or serrated shape.
  • Second edge 62 is generally opposite first edge 55 and is inclined relative to first edge 55 .
  • Knob 60 extends from first edge 55 in a direction opposite second edge 62 .
  • Cassette frame 22 may include a peripheral wall 63 which extends from peripheral edge 61 and defines slot 53 within which knob 60 is configured to move.
  • Cassette frame 22 further may include an interior surface 57 , which extends from peripheral wall 63 in a generally perpendicular direction to peripheral wall 63 .
  • Interior surface 57 defines a surface of a hollow 54 formed within top brace 29 .
  • Cam position selector switch 56 is received within slot 53 and hollow 54 of cassette frame 22 .
  • interior surface 57 includes a second plurality of ridges.
  • the plurality of ridges of first edge 55 of cam position selector switch 56 are configured to abut the second plurality of ridges of interior surface 57 of cassette frame 22 .
  • the plurality of ridges of first edge 55 of cam position selector switch 56 and the second plurality of ridges of interior surface 57 form a series of cogs which engage with each other.
  • Cassette frame 22 further may include a push button 50 mounted for movement in a first direction within hollow 54 .
  • Push button 50 may have the general shape of a rectangular parallelepiped.
  • the underside of push button 50 may be in contact with an upper side of the center of biasing member 38 .
  • the underside of push button 50 may be mounted to the upper side of the center of biasing member 38 .
  • Push button 50 slides within two channels 52 located within top brace 29 . The channels extend generally perpendicular to the elongate direction of top brace 29 so that push button 50 may move vertically.
  • biasing member 38 extends near a central part of top brace 29 .
  • biasing member 38 includes two tips 27 .
  • Hooks 40 may extend from an upper edge 41 of cam 32 generally opposite lower edge 34 .
  • Cam 32 mounts to biasing member 38 near the tips 27 , for example, using the hooks 40 .
  • the tips 27 are visible through openings 42 located in front wall 36 and the back wall of cassette frame 22 .
  • cam position selector switch 56 rests against push button 50 which contacts biasing member 38 , which acts downwards on cam 32 , which in turn acts downwards on tube 24 and towards the plurality of rollers 8 .
  • Cam position selector switch 56 thereby provides a control of the cam's compression force on tube 24 .
  • Moving knob 60 of cam position selector switch 56 in the first direction which defines the direction of movement of push button 50 , releases first edge 55 of cam position selector switch 56 from the second plurality of ridges of interior surface 57 of cassette frame 22 .
  • the first direction is towards cam 32 .
  • Moving knob 60 of cam position selector switch 56 in a second direction after releasing cam position selector switch 56 from cassette frame 22 adjusts a position of cam 32 relative to cassette frame 22 due to the inclined surface of second edge 62 .
  • Cam 32 moves toward or away from the plurality of rollers 8 depending on the direction of the slope of second edge 62 and the direction of movement, by the user, of knob 60 .
  • the second direction is approximately perpendicular to the first direction and in the elongate direction of top brace 29 .
  • Releasing cam position selector switch 56 causes the plurality of ridges of first edge 55 to again abut the second plurality of ridges of interior surface 57 though possibly with a different alignment of ridges.
  • Releasing cam position selector switch 56 holds cam position selector switch 56 in position through the interaction of the plurality of ridges of first edge 55 which cooperate with the second plurality of ridges of interior surface 57 and through the compression force exerted by biasing member 38 .
  • the upper side of cassette 18 can be marked to indicate various positions of cam position selector switch 56 corresponding to a predetermined compression strength.
  • a scale can therefore be used to identify and to control the compression strength
  • the scale may be based on the diameter of tube 24 used.
  • the method and system described provide control of the compression force on tube 24 .
  • the compression force can be optimized for the desired flow rate and pressure based on certain characteristics of the fluid flowing through tube 24 . Additionally, an improved efficiency and a longer tube lifetime can be achieved.
  • Moving cam position selector switch 56 changes the compression of biasing member 38 , and therefore, by interaction, the strength of the compression force on tube 24 via cam 32 .
  • the complementary shape of the plurality of ridges ensures that cam position selector switch 56 remains in its resting position, while permitting modulation of the compression force simply and quickly.

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Reciprocating Pumps (AREA)
  • External Artificial Organs (AREA)
US11/612,011 2004-06-22 2006-12-18 Method and system for providing adjustable compression force on a tube in a peristaltic pump Abandoned US20070217932A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0406764A FR2871857B1 (fr) 2004-06-22 2004-06-22 Cassette de pompe peristaltique comprenant un organe de reglage du pincement du tube
FR0406764 2004-06-22
PCT/FR2005/001524 WO2006008376A1 (fr) 2004-06-22 2005-06-17 Cassette de pompe peristaltique comprenant un organe de reglage du pincement du tube

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2005/001524 Continuation WO2006008376A1 (fr) 2004-06-22 2005-06-17 Cassette de pompe peristaltique comprenant un organe de reglage du pincement du tube

Publications (1)

Publication Number Publication Date
US20070217932A1 true US20070217932A1 (en) 2007-09-20

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ID=34947371

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US11/612,011 Abandoned US20070217932A1 (en) 2004-06-22 2006-12-18 Method and system for providing adjustable compression force on a tube in a peristaltic pump

Country Status (15)

Country Link
US (1) US20070217932A1 (de)
EP (1) EP1771662B1 (de)
JP (1) JP2008503688A (de)
KR (1) KR20070033003A (de)
CN (1) CN1973132A (de)
AT (1) ATE385543T1 (de)
CA (1) CA2571734A1 (de)
DE (1) DE602005004665T2 (de)
DK (1) DK1771662T3 (de)
ES (1) ES2301046T3 (de)
FR (1) FR2871857B1 (de)
PL (1) PL1771662T3 (de)
RU (1) RU2006144289A (de)
TW (1) TW200606339A (de)
WO (1) WO2006008376A1 (de)

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US20100047099A1 (en) * 2008-08-20 2010-02-25 Seiko Epson Corporation Micropump
US20100080720A1 (en) * 2008-09-29 2010-04-01 Seiko Epson Corporation Control unit, tube unit, and micropump
US20100143168A1 (en) * 2008-12-05 2010-06-10 Seiko Epson Corporation Tube unit, control unit, and micropump
US7934912B2 (en) 2007-09-27 2011-05-03 Curlin Medical Inc Peristaltic pump assembly with cassette and mounting pin arrangement
US20110186143A1 (en) * 2010-02-03 2011-08-04 Seiko Epson Corporation Fluid transporter
US8062008B2 (en) 2007-09-27 2011-11-22 Curlin Medical Inc. Peristaltic pump and removable cassette therefor
US8083503B2 (en) 2007-09-27 2011-12-27 Curlin Medical Inc. Peristaltic pump assembly and regulator therefor
US20120148415A1 (en) * 2010-12-09 2012-06-14 Fresenius Medical Care Deutschland Gmbh Pump rotor
US20140135731A1 (en) * 2012-11-14 2014-05-15 Covidien Lp Feeding Set with Cassette and Related Methods Therefor
US9381288B2 (en) 2013-03-13 2016-07-05 Thoratec Corporation Fluid handling system
USD762850S1 (en) 2013-04-23 2016-08-02 Covidien Lp Cassette
US9504784B2 (en) 2011-09-15 2016-11-29 Cole-Parmer Instrument Company Llc Peristaltic pump with multiple independent channels
US9713660B2 (en) 2012-12-21 2017-07-25 Alcon Research, Ltd. Cassette clamp mechanism
US10071192B2 (en) 2013-03-15 2018-09-11 Tc1 Llp Catheter pump assembly including a stator
US10449279B2 (en) 2014-08-18 2019-10-22 Tc1 Llc Guide features for percutaneous catheter pump
US10525178B2 (en) 2013-03-15 2020-01-07 Tc1 Llc Catheter pump assembly including a stator
USD879948S1 (en) * 2016-12-23 2020-03-31 Brightwell Dispensers Limited Peristaltic pump
US10709830B2 (en) 2015-01-22 2020-07-14 Tc1 Llc Reduced rotational mass motor assembly for catheter pump
US10765789B2 (en) 2012-05-14 2020-09-08 Tc1 Llc Impeller for catheter pump
US10864308B2 (en) 2014-04-15 2020-12-15 Tc1 Llc Sensors for catheter pumps
US10960116B2 (en) 2011-01-06 2021-03-30 Tci Llc Percutaneous heart pump
US11033728B2 (en) 2013-03-13 2021-06-15 Tc1 Llc Fluid handling system
US11058865B2 (en) 2012-07-03 2021-07-13 Tc1 Llc Catheter pump
USD930152S1 (en) * 2016-08-18 2021-09-07 Brightwell Dispensers Limited Peristaltic pump
US11160970B2 (en) 2016-07-21 2021-11-02 Tc1 Llc Fluid seals for catheter pump motor assembly
USD938017S1 (en) * 2016-08-18 2021-12-07 Brightwell Dispensers Limited Peristaltic pump
US11229786B2 (en) 2012-05-14 2022-01-25 Tc1 Llc Impeller for catheter pump
US11491322B2 (en) 2016-07-21 2022-11-08 Tc1 Llc Gas-filled chamber for catheter pump motor assembly
US11692540B2 (en) 2017-11-08 2023-07-04 Oina Vv Ab Peristaltic pump
WO2023165938A1 (en) * 2022-03-01 2023-09-07 Aliva AS Liquid distribution system

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US8272857B2 (en) 2008-02-22 2012-09-25 Medtronic Xomed, Inc. Method and system for loading of tubing into a pumping device
JP2010043600A (ja) * 2008-08-12 2010-02-25 Osada Res Inst Ltd ローラポンプ
CA2791344C (en) * 2012-09-26 2019-07-16 Capmatic Ltee Peristaltic pump
EP3467309B1 (de) 2017-10-06 2020-02-26 The Automation Partnership (Cambridge) Limited Vorrichtung und verfahren zur verbesserung und auswertung der stabilität gepumpter proteinlösungen in bioverarbeitungssystemen
KR102136683B1 (ko) 2019-02-27 2020-07-22 박종환 식품가공용 고점도 액상체의 이송효율이 개선된 튜브연동펌프
AU2020239989A1 (en) * 2019-03-15 2021-10-07 Nxstage Medical, Inc. Peristaltic pump
US11708855B2 (en) 2019-07-15 2023-07-25 The Timken Company Two-piece composite tapered roller bearing outer ring with interference fit

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US4886431A (en) * 1988-04-29 1989-12-12 Cole-Parmer Instrument Company Peristaltic pump having independently adjustable cartridges
US5096393A (en) * 1989-08-28 1992-03-17 Csir Peristaltic pump with hinged rotor support housing and adjustable tube rack
US5249937A (en) * 1991-06-12 1993-10-05 Smh Management Services Ag Peristaltic pump with three lockingly sealed modules
US5213483A (en) * 1991-06-19 1993-05-25 Strato Medical Corporation Peristaltic infusion pump with removable cassette and mechanically keyed tube set
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Cited By (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7934912B2 (en) 2007-09-27 2011-05-03 Curlin Medical Inc Peristaltic pump assembly with cassette and mounting pin arrangement
US8062008B2 (en) 2007-09-27 2011-11-22 Curlin Medical Inc. Peristaltic pump and removable cassette therefor
US8083503B2 (en) 2007-09-27 2011-12-27 Curlin Medical Inc. Peristaltic pump assembly and regulator therefor
US9657731B2 (en) 2008-08-20 2017-05-23 Seiko Epson Corporation Micropump
US8491283B2 (en) * 2008-08-20 2013-07-23 Seiko Epson Corporation Micropump
US20100047099A1 (en) * 2008-08-20 2010-02-25 Seiko Epson Corporation Micropump
US20100080720A1 (en) * 2008-09-29 2010-04-01 Seiko Epson Corporation Control unit, tube unit, and micropump
US9631615B2 (en) 2008-09-29 2017-04-25 Seiko Epson Corporation Control unit, tube unit, and micropump
US8491284B2 (en) 2008-09-29 2013-07-23 Seiko Epson Corporation Control unit, tube unit, and micropump
US20100143168A1 (en) * 2008-12-05 2010-06-10 Seiko Epson Corporation Tube unit, control unit, and micropump
US9447783B2 (en) 2008-12-05 2016-09-20 Seiko Epson Corporation Tube unit, control unit, and micropump
US8491286B2 (en) 2008-12-05 2013-07-23 Seiko Epson Corporation Tube unit, control unit, and micropump
US20110186143A1 (en) * 2010-02-03 2011-08-04 Seiko Epson Corporation Fluid transporter
US20120148415A1 (en) * 2010-12-09 2012-06-14 Fresenius Medical Care Deutschland Gmbh Pump rotor
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KR20070033003A (ko) 2007-03-23
ATE385543T1 (de) 2008-02-15
TW200606339A (en) 2006-02-16
DE602005004665D1 (de) 2008-03-20
CA2571734A1 (en) 2006-01-26
FR2871857A1 (fr) 2005-12-23
RU2006144289A (ru) 2008-07-27
CN1973132A (zh) 2007-05-30
PL1771662T3 (pl) 2008-07-31
DE602005004665T2 (de) 2009-02-05
ES2301046T3 (es) 2008-06-16
FR2871857B1 (fr) 2008-09-12
EP1771662B1 (de) 2008-02-06
WO2006008376A1 (fr) 2006-01-26
JP2008503688A (ja) 2008-02-07
DK1771662T3 (da) 2008-05-26
EP1771662A1 (de) 2007-04-11

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