US20050255580A1 - Miniaturized microtiter plate for HT-screening - Google Patents
Miniaturized microtiter plate for HT-screening Download PDFInfo
- Publication number
- US20050255580A1 US20050255580A1 US11/121,536 US12153605A US2005255580A1 US 20050255580 A1 US20050255580 A1 US 20050255580A1 US 12153605 A US12153605 A US 12153605A US 2005255580 A1 US2005255580 A1 US 2005255580A1
- Authority
- US
- United States
- Prior art keywords
- microtiter plate
- vessels
- wells
- base
- screening
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00306—Reactor vessels in a multiple arrangement
- B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
- B01J2219/00315—Microtiter plates
- B01J2219/00317—Microwell devices, i.e. having large numbers of wells
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0893—Geometry, shape and general structure having a very large number of wells, microfabricated wells
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
Definitions
- the invention relates to a miniaturized microtiter plate for HT screening (high throughput screening).
- microtiter plates having an assay volume of about 0.5 to 10 ⁇ l, preferably 1 to 6 ⁇ l, particularly preferably 1 to 2 ⁇ l.
- the only ones available to date are a few prototypes which can be processed only by particular analyzers.
- microtiter plates which permit analysis with very sensitive detectors (with confocal optics) and allow charging with “nanodispensers”.
- a further desirable feature is prevention of evaporation.
- Microtiter plates have been disclosed by Greiner, 64943 Hirschberg, (Micro-Assay Plate, 1536 wells). In this case, the effective volume of the sample carriers is relatively large (4-8 ⁇ l) and they do not permit “single molecule detection”. Although the effective volume of the Corning Costar microtiter plates (Corning Costar GmbH, 55924 Bodenheim) is between 1 and 2 ⁇ l, the frame of the microtiter plates is too thin so that conventional robotic systems are unable to transport the microtiter plates. “Single molecule detection” is impossible in this case, too.
- a Hellma brochure (1994) “Silica Glass Microassay Plates” discloses microassay plates with a base made of silica glass and 384 wells with a diameter of 3.5 mm. However, besides the large assay volume, these microassay plates have frames which are insufficiently broad and bases which are too thick (>1 mm) to allow analysis using confocal optics.
- U.S. Pat. No. 5,487,872 describes multiassay microtiter plates for UV spectroscopy having glass plates with a minimum thickness of 0.38 mm. These microtiter plates are also unsuitable for analysis using confocal optics. Microassay plates with lids to prevent evaporation are described in a Radleys brochure (1997) “Specialist Micro Titer Plates & Accessories”.
- the object of the invention is to provide a remedy for this.
- a miniaturized microtiter plate which has a body made of plastic and a base made of glass and has 1000 to 4000 vessels (wells), preferably 1400 to 2500 vessels (wells), particularly preferably 1536 vessels (wells), the diameter of the vessels (wells) is approximately 1.0 to 1.8 mm, preferably 1.2 to 1.5 mm, the base of the microtiter plate has a thickness of 0.07 to 0.2 mm, preferably 0.12 to 0.17 mm, particularly preferably 0.15 mm, the distance between the center of the outer vessels (wells) and the edge of the glass base is 4 to 11 mm, preferably >(greater than/equal to) 5.5 mm and the microtiter plate has a lid to prevent evaporation.
- the miniaturized microtiter plate usually has a size of 10.0-15.0 ⁇ 7.0-10.0 cm, preferably 12.7 ⁇ 8.5 cm. However, sizes differing from this are also possible.
- the shape of the vessels (wells) is variable. Thus, for example, vessels which are round, have corners or have rounded corners can be used. Round vessels are preferred. It is likewise possible for the number of vessels (wells) to differ from the abovementioned values.
- the angle between base and wall of the wells can vary between 20° and 90°.
- the body of the microtiter plate consists of plastic such as, for example, polystyrene, polypropylene, polycarbonate, Vectra®, Hostalen®, Topas®.
- the microtiter plates are usually produced by injection molding (or embossing). The plastic cools after the injection molding. Warping of the microtiter plate is possible during this (because of local differences in the rate of cooling). It is thus beneficial to use a material which produces only a very slight “curvature”.
- the lid of the microtiter plate is likewise made of plastic and sits form-fittingly on the microtiter plate.
- the thickness of the base (material: glass) of the microtiter plate (0.07-0.20 mm) and the diameter of the vessels (about 1.0-1.8 mm), and the distance between the center of the outer vessels (wells) and the edge of the glass base, which is 4 to 11 mm, allow analysis of the microtiter plate using confocal optics.
- the use of confocal optics has the following advantages:
- the base, which consists of glass, of the microtiter plate can be coated with various chemical and biological substances, such as, for example, cellulose, cellulose derivatives, dextrans, polyethylene glycols, in order to suppress nonspecific binding. It ought likewise to be possible for the base to carry biological molecules which specifically bind other substances. The latter is important for use in drug screening, for example for sandwich assays.
- FIG. 1 Perspective depiction of the microtiter plate with lid lifted off
- FIG. 2 Section along plane II-II from FIG. 1
- FIG. 3 Section along plane III-III from FIG. 1
- FIG. 1 shows a perspective depiction of the microtiter plate with vessels ( 3 ).
- the lid ( 4 ) with projections ( 5 ) is shown in the lifted-off state.
- FIG. 2 depicts a section along plane II-II.
- the glass base ( 2 ) is fastened underneath the microtiter plate.
- the edge distance (a 1 ) is 3-8 mm, preferably 6 mm, and the distance (a 2 ) is 6-11 mm, preferably 9.5 mm.
- the corresponding edge distance (b 1 ) in FIG. 3 is likewise 3-8 mm, preferably 6 mm, and the distance (b 2 ) is 4-11 mm, preferably 6.5 mm.
- the distances between the center of the outer vessels (wells) and the edge of the glass base (a 3 , b 3 ) are 4-11 mm.
- the vessel diameter (d) is between 1.0 and 1.8 mm, particularly preferably 1.3 mm, the vessel distance (a 4 ) is 2.25 mm and the vessel height (h) is between 2.0 and 7.0 mm.
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Optical Measuring Cells (AREA)
- Electron Tubes For Measurement (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Devices For Use In Laboratory Experiments (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Inorganic Insulating Materials (AREA)
- Geophysics And Detection Of Objects (AREA)
- Sampling And Sample Adjustment (AREA)
- Molds, Cores, And Manufacturing Methods Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/121,536 US20050255580A1 (en) | 1998-03-27 | 2005-05-02 | Miniaturized microtiter plate for HT-screening |
US12/127,965 US7951337B2 (en) | 1998-03-27 | 2008-05-28 | Miniaturized microtiter plate for HT-screening |
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE29805613U DE29805613U1 (de) | 1998-03-27 | 1998-03-27 | Miniaturisierte Mikrotiterplatte für das HTS-Screening |
DE1998136505 DE19836505A1 (de) | 1998-08-12 | 1998-08-12 | Miniaturisierte Mikrotiterplatte für das HTS-Screening |
DE19836505.5 | 1998-10-01 | ||
DE29817526U DE29817526U1 (de) | 1998-10-01 | 1998-10-01 | Miniaturisierte Mikrotiterplatte für das HTS-Screening |
DE29805613.5 | 1998-10-01 | ||
DE29817256.6 | 1998-10-01 | ||
PCT/EP1999/001729 WO1999049973A1 (de) | 1998-03-27 | 1999-03-17 | Miniaturisierte mikrotiterplatte für hochdurchsatz-screening |
US64698600A | 2000-09-26 | 2000-09-26 | |
US11/121,536 US20050255580A1 (en) | 1998-03-27 | 2005-05-02 | Miniaturized microtiter plate for HT-screening |
Related Parent Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1999/001729 Continuation WO1999049973A1 (de) | 1998-03-27 | 1999-03-17 | Miniaturisierte mikrotiterplatte für hochdurchsatz-screening |
US09646986 Continuation | 1999-03-17 | ||
US64698600A Continuation | 1998-03-27 | 2000-09-26 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/127,965 Continuation US7951337B2 (en) | 1998-03-27 | 2008-05-28 | Miniaturized microtiter plate for HT-screening |
Publications (1)
Publication Number | Publication Date |
---|---|
US20050255580A1 true US20050255580A1 (en) | 2005-11-17 |
Family
ID=27218589
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/121,536 Abandoned US20050255580A1 (en) | 1998-03-27 | 2005-05-02 | Miniaturized microtiter plate for HT-screening |
US12/127,965 Expired - Fee Related US7951337B2 (en) | 1998-03-27 | 2008-05-28 | Miniaturized microtiter plate for HT-screening |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/127,965 Expired - Fee Related US7951337B2 (en) | 1998-03-27 | 2008-05-28 | Miniaturized microtiter plate for HT-screening |
Country Status (11)
Country | Link |
---|---|
US (2) | US20050255580A1 (de) |
EP (1) | EP1066112B1 (de) |
JP (1) | JP4499918B2 (de) |
AT (1) | ATE229373T1 (de) |
AU (1) | AU3413499A (de) |
CA (1) | CA2326107C (de) |
DE (1) | DE59903746D1 (de) |
DK (1) | DK1066112T3 (de) |
ES (1) | ES2184434T3 (de) |
PT (1) | PT1066112E (de) |
WO (1) | WO1999049973A1 (de) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070077181A1 (en) * | 2005-10-04 | 2007-04-05 | Youngbear Kathy M | Multiwell plate with modified rib configuration |
US20100028895A1 (en) * | 2007-01-10 | 2010-02-04 | Sanofi-Aventis | Method for determining the stability of organic methyleneamines in the presence of semicarbazide-sensitive amine oxidase |
US20100143937A1 (en) * | 2007-05-31 | 2010-06-10 | Sanofi-Aventis | ASSAY METHODS FOR IDENTIFYING AGENTS THAT MODIFY THE ACTIVITY OF NAPE-PLD OR Abh4 |
US20100248224A1 (en) * | 2006-06-21 | 2010-09-30 | Sanofi-Aventis | Dna fragmentation assay |
WO2011084659A1 (en) | 2009-12-21 | 2011-07-14 | Sanofi-Aventis | Transgenic non-human animal and uses thereof |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU1591301A (en) * | 1999-11-09 | 2001-06-06 | Sri International | Workstation, apparatus, and methods for the high-throughput synthesis, screeningand characterization of combinatorial libraries |
DE60126077D1 (de) * | 2000-05-08 | 2007-03-08 | Vivactis Nv | Verfahren zur hochdurchsatzprofilierung neuer werkstoffe |
DE10147513B4 (de) * | 2000-09-27 | 2006-03-09 | Evotec Oai Ag | Verfahren zur Minimierung der Verdunstung in Probenträgern |
JP4639558B2 (ja) * | 2001-09-07 | 2011-02-23 | 株式会社島津製作所 | マイクロウエルチップ |
JP2004109107A (ja) * | 2002-07-25 | 2004-04-08 | Nippon Sheet Glass Co Ltd | 生化学用容器 |
WO2004086010A1 (ja) * | 2003-03-24 | 2004-10-07 | Hitachi Software Engineering Co., Ltd. | 吸光度読取装置、吸光度読取装置制御方法及び吸光度算出プログラム |
EP2977757B1 (de) * | 2004-04-07 | 2017-09-13 | Abbott Laboratories | Einwegkammer zur analyse biologischer flüssigkeiten |
US7731901B2 (en) | 2005-10-19 | 2010-06-08 | Abbott Laboratories | Apparatus and method for performing counts within a biologic fluid sample |
JP5709894B2 (ja) * | 2009-12-18 | 2015-04-30 | アボット ポイント オブ ケア インコーポレイテッド | 生物学的液体分析カートリッジ |
US9873118B2 (en) | 2010-12-30 | 2018-01-23 | Abbott Point Of Care, Inc. | Biologic fluid analysis cartridge with sample handling portion and analysis chamber portion |
CN105817276B (zh) | 2011-08-24 | 2018-02-06 | 艾博特健康公司 | 生物流体样品分析盒 |
US20170205318A1 (en) * | 2014-07-17 | 2017-07-20 | University Of Washington | Ultrasound system for shearing cellular material |
JP3198828U (ja) * | 2015-05-14 | 2015-07-23 | 国立研究開発法人農業・食品産業技術総合研究機構 | マイクロプレート |
US10809166B2 (en) | 2017-01-20 | 2020-10-20 | Matchstick Technologies, Inc. | Ultrasound system for shearing cellular material in a microplate |
Citations (15)
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US5084246A (en) * | 1986-10-28 | 1992-01-28 | Costar Corporation | Multi-well test plate |
US5380493A (en) * | 1992-03-27 | 1995-01-10 | Chavez; Jeffery B. | Cell well plate holder and well marking system |
US5457527A (en) * | 1992-05-28 | 1995-10-10 | Packard Instrument Company, Inc. | Microplate forming wells with transparent bottom walls for assays using light measurements |
US5738825A (en) * | 1993-07-20 | 1998-04-14 | Balzers Aktiengesellschaft | Optical biosensor matrix |
US5817509A (en) * | 1997-03-19 | 1998-10-06 | Becton Dickinson And Company | Culture vessel assembly |
US5989854A (en) * | 1993-05-17 | 1999-11-23 | Amersham International Plc | Vessels and multiwell plates having a scintillant base |
US6027695A (en) * | 1998-04-01 | 2000-02-22 | Dupont Pharmaceuticals Company | Apparatus for holding small volumes of liquids |
US6063338A (en) * | 1997-06-02 | 2000-05-16 | Aurora Biosciences Corporation | Low background multi-well plates and platforms for spectroscopic measurements |
US6074614A (en) * | 1995-06-07 | 2000-06-13 | Molecular Devices Corporation | Multi-assay plate cover for elimination of meniscus |
US6171780B1 (en) * | 1997-06-02 | 2001-01-09 | Aurora Biosciences Corporation | Low fluorescence assay platforms and related methods for drug discovery |
US6258325B1 (en) * | 1993-04-19 | 2001-07-10 | Ashok Ramesh Sanadi | Method and apparatus for preventing cross-contamination of multi-well test plates |
US6316774B1 (en) * | 1998-08-18 | 2001-11-13 | Molecular Devices Corporation | Optical system for a scanning fluorometer |
US6340589B1 (en) * | 1999-07-23 | 2002-01-22 | Mj Research, Inc. | Thin-well microplate and methods of making same |
US6419827B1 (en) * | 1998-10-29 | 2002-07-16 | Applera Corporation | Purification apparatus and method |
US6503456B1 (en) * | 1997-03-25 | 2003-01-07 | Greiner Bio-One Gmbh | Microplate with transparent base |
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JPH0672839B2 (ja) * | 1985-08-28 | 1994-09-14 | 呉羽化学工業株式会社 | 微量液体反応容器 |
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NL9101953A (nl) * | 1991-11-21 | 1993-06-16 | Seed Capital Investments | Testinrichting omvattende een plaat met een veelvoud van putjes met een bijbehorende doseerinrichting, alsmede een kit die deze inrichtingen omvat en toepassing van de inrichtingen. |
US5487872A (en) | 1994-04-15 | 1996-01-30 | Molecular Device Corporation | Ultraviolet radiation transparent multi-assay plates |
US5587321A (en) * | 1995-07-31 | 1996-12-24 | University Of Kansas | Moated tissue culture plate |
JPH0972843A (ja) * | 1995-09-06 | 1997-03-18 | Nikon Corp | ウェルプレート |
JPH09218149A (ja) * | 1996-02-15 | 1997-08-19 | Shimadzu Corp | 検出計セルおよび光学測定装置 |
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CN1244140A (zh) * | 1997-01-17 | 2000-02-09 | 康宁股份有限公司 | 多穴板 |
-
1999
- 1999-03-17 DE DE59903746T patent/DE59903746D1/de not_active Expired - Lifetime
- 1999-03-17 WO PCT/EP1999/001729 patent/WO1999049973A1/de active IP Right Grant
- 1999-03-17 ES ES99915629T patent/ES2184434T3/es not_active Expired - Lifetime
- 1999-03-17 DK DK99915629T patent/DK1066112T3/da active
- 1999-03-17 PT PT99915629T patent/PT1066112E/pt unknown
- 1999-03-17 JP JP2000540932A patent/JP4499918B2/ja not_active Expired - Lifetime
- 1999-03-17 AU AU34134/99A patent/AU3413499A/en not_active Abandoned
- 1999-03-17 EP EP99915629A patent/EP1066112B1/de not_active Expired - Lifetime
- 1999-03-17 CA CA002326107A patent/CA2326107C/en not_active Expired - Lifetime
- 1999-03-17 AT AT99915629T patent/ATE229373T1/de active
-
2005
- 2005-05-02 US US11/121,536 patent/US20050255580A1/en not_active Abandoned
-
2008
- 2008-05-28 US US12/127,965 patent/US7951337B2/en not_active Expired - Fee Related
Patent Citations (15)
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US5084246A (en) * | 1986-10-28 | 1992-01-28 | Costar Corporation | Multi-well test plate |
US5380493A (en) * | 1992-03-27 | 1995-01-10 | Chavez; Jeffery B. | Cell well plate holder and well marking system |
US5457527A (en) * | 1992-05-28 | 1995-10-10 | Packard Instrument Company, Inc. | Microplate forming wells with transparent bottom walls for assays using light measurements |
US6258325B1 (en) * | 1993-04-19 | 2001-07-10 | Ashok Ramesh Sanadi | Method and apparatus for preventing cross-contamination of multi-well test plates |
US5989854A (en) * | 1993-05-17 | 1999-11-23 | Amersham International Plc | Vessels and multiwell plates having a scintillant base |
US5738825A (en) * | 1993-07-20 | 1998-04-14 | Balzers Aktiengesellschaft | Optical biosensor matrix |
US6074614A (en) * | 1995-06-07 | 2000-06-13 | Molecular Devices Corporation | Multi-assay plate cover for elimination of meniscus |
US5817509A (en) * | 1997-03-19 | 1998-10-06 | Becton Dickinson And Company | Culture vessel assembly |
US6503456B1 (en) * | 1997-03-25 | 2003-01-07 | Greiner Bio-One Gmbh | Microplate with transparent base |
US6171780B1 (en) * | 1997-06-02 | 2001-01-09 | Aurora Biosciences Corporation | Low fluorescence assay platforms and related methods for drug discovery |
US6063338A (en) * | 1997-06-02 | 2000-05-16 | Aurora Biosciences Corporation | Low background multi-well plates and platforms for spectroscopic measurements |
US6027695A (en) * | 1998-04-01 | 2000-02-22 | Dupont Pharmaceuticals Company | Apparatus for holding small volumes of liquids |
US6316774B1 (en) * | 1998-08-18 | 2001-11-13 | Molecular Devices Corporation | Optical system for a scanning fluorometer |
US6419827B1 (en) * | 1998-10-29 | 2002-07-16 | Applera Corporation | Purification apparatus and method |
US6340589B1 (en) * | 1999-07-23 | 2002-01-22 | Mj Research, Inc. | Thin-well microplate and methods of making same |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070077181A1 (en) * | 2005-10-04 | 2007-04-05 | Youngbear Kathy M | Multiwell plate with modified rib configuration |
US20100248224A1 (en) * | 2006-06-21 | 2010-09-30 | Sanofi-Aventis | Dna fragmentation assay |
US20100028895A1 (en) * | 2007-01-10 | 2010-02-04 | Sanofi-Aventis | Method for determining the stability of organic methyleneamines in the presence of semicarbazide-sensitive amine oxidase |
US8883410B2 (en) | 2007-01-10 | 2014-11-11 | Sanofi | Method for determining the stability of organic methyleneamines in the presence of semicarbazide-sensitive amine oxidase |
US20100143937A1 (en) * | 2007-05-31 | 2010-06-10 | Sanofi-Aventis | ASSAY METHODS FOR IDENTIFYING AGENTS THAT MODIFY THE ACTIVITY OF NAPE-PLD OR Abh4 |
WO2011084659A1 (en) | 2009-12-21 | 2011-07-14 | Sanofi-Aventis | Transgenic non-human animal and uses thereof |
Also Published As
Publication number | Publication date |
---|---|
US20090104081A1 (en) | 2009-04-23 |
US7951337B2 (en) | 2011-05-31 |
PT1066112E (pt) | 2003-04-30 |
DK1066112T3 (da) | 2003-03-17 |
ES2184434T3 (es) | 2003-04-01 |
ATE229373T1 (de) | 2002-12-15 |
JP4499918B2 (ja) | 2010-07-14 |
AU3413499A (en) | 1999-10-18 |
DE59903746D1 (de) | 2003-01-23 |
CA2326107C (en) | 2008-11-04 |
EP1066112B1 (de) | 2002-12-11 |
EP1066112A1 (de) | 2001-01-10 |
WO1999049973A1 (de) | 1999-10-07 |
CA2326107A1 (en) | 1999-10-07 |
JP2002510036A (ja) | 2002-04-02 |
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