US20050089994A1 - Peritoneal dialysis system - Google Patents

Peritoneal dialysis system Download PDF

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Publication number
US20050089994A1
US20050089994A1 US10/501,394 US50139404A US2005089994A1 US 20050089994 A1 US20050089994 A1 US 20050089994A1 US 50139404 A US50139404 A US 50139404A US 2005089994 A1 US2005089994 A1 US 2005089994A1
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United States
Prior art keywords
peritoneal dialysis
sampling
automatic
peritoneal
draining
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10/501,394
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English (en)
Inventor
Frederic Neftel
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Debiotech SA
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Debiotech SA
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Publication date
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Application filed by Debiotech SA filed Critical Debiotech SA
Assigned to DEBIOTECH S.A. reassignment DEBIOTECH S.A. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: NEFTEL, FREDERIC
Publication of US20050089994A1 publication Critical patent/US20050089994A1/en
Priority to US13/180,547 priority Critical patent/US9125989B2/en
Priority to US13/507,087 priority patent/US9149571B2/en
Priority to US14/836,886 priority patent/US9983101B2/en
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/28—Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis

Definitions

  • the present invention relates to a peritoneal dialysis sampling system to be used in a peritoneal dialysis system which is programmed to deliver fluid to a peritoneal cavity of a patient and to drain the fluid from the cavity, said peritoneal dialysis system comprising a supplying line and supplying means for supplying dialysis fluid to the peritoneal cavity, a draining line and draining means for draining the fluid from the cavity.
  • One of the object of the present invention is to avoid the previous listed problems.
  • a peritoneal dialysis sampling system to be used in a peritoneal dialysis system which is programmed to deliver fluid to a peritoneal cavity of a patient and to drain the fluid from the cavity
  • said peritoneal dialysis system comprising a supplying line and supplying means for supplying dialysis fluid to the peritoneal cavity, a draining line and draining means for draining the fluid from the cavity
  • said peritoneal dialysis sampling system being characterized by the fact that it consists of an automatic sampling system which is able to automatically sample volumic fractions of the dialysate contained in the peritoneum of the patient at specific time intervals in order to evaluate the peritoneal membrane characteristics and/or improve the peritoneal dialysis for a given patient.
  • the automatic sampling system is connected on the draining line either between the patient peritoneum and the draining means or between the draining means and a waste collector.
  • the possibility to increase the number of sampling steps and automatically vary the dialysate volume and concentration over a certain period of time allows to increase the number of information collected over a limited period of time.
  • a full and more detailed patient peritoneal membrane evaluation can be made over a shorter period of time, allowing such evaluation to be conducted automatically preferably overnight.
  • the automatic peritoneal dialysis sampling system is provided with means for defining the specific time intervals for sampling volumic fractions in relation with the peritoneal dialysis program sequences.
  • the evaluation of the peritoneal membrane characteristics may be improved by providing the automatic peritoneal dialysis sampling system with means, e.g. a system of valves and separate fluidic paths, in order to sample different peritoneal dialysis fractions and collect them in separate containers for a later detailed analysis of their specific content.
  • means e.g. a system of valves and separate fluidic paths
  • the automatic peritoneal dialysis sampling system may be connected between the patient peritoneum and the draining means, requiring sampling means to sample liquid from the peritoneum at different points of time.
  • the sampling means may, for example, be of a peristal type allowing a precise volumic sampling:
  • the sampling means may result from vacuum originating from the sampling containers which may be controlled by a series of valves, or by gravity.
  • the automatic peritoneal dialysis sampling system may be connected after the draining means, such draining means being used, in such case, for both draining the dialysis fluid after each cycle as well as collecting the sampling fractions.
  • the draining means would be activated to sample the volumic fraction required during dwell time, while in the drain phase of each cycle only a fraction of the drainage volume would be collected by use, for example, of a valve system.
  • connection of the automatic peritoneal dialysis sampling system to the draining line may also be made by an electromechanical valve which is actuated in relation with a specific functioning of the draining means.
  • the automatic sampling can be made during the dwell time of the peritoneal dialysis cycle and/or during the drain cycle without interfering with the peritoneal dialysis system.
  • the automatic sampling can only occur during the drain phase of each cycle or, alternatively, can also occur during the dwell time provided the draining means are activated during such dwell time for that purpose.
  • the automatic peritoneal sampling system requires sampling means, while in the latest case the draining means of the peritoneal dialysis system are also used for sampling purposes.
  • the sampling means if required, preferably include pumping means such as a peristaltic pump. They may also be of a gravity type, or vacuum type, if in connection with a series of valves.
  • the automatic sampling system comprises a series of sampling containers, pumping means and a series of valves in order to direct a certain quantity of each fluid sample to a given sampling container.
  • the sampling containers may consist of soft pouches.
  • the automatic sampling system may be composed of a series of valves which are controlled by an electronic system in order to direct a certain quantity of each fluid sample to a specific sampling container.
  • the valves may be of electromagnetic type.
  • the automatic sampling system comprises means for eliminating a volume of liquid between two samplings at least equivalent to the dead volume contained between the patient and the sampling level.
  • This can be done by providing the system with a purging line.
  • the draining line is connected to the purging line in order to purge the above cited dead volume in order to prevent mixing of two different samples.
  • a second sampling occurs then when the draining line is connected to another sampling container.
  • Purging can be obtained either by use of the sampling means or, in the configuration with draining means from the automatic peritoneal dialysis system, by use of such draining means.
  • both systems the peritoneal dialysis system which comprises an automatic peritoneal dialysis exchange system, and the automatic peritoneal dialysis sampling system are connected to the patient peritoneum and comprise means for exchanging information together in order for the automatic peritoneal dialysis sampling system to determine the appropriate timing for each sampling on the basis of the dialysis exchange cycles of the automatic peritoneal dialysis exchange system.
  • the automatic sampling system under the present invention can also be used to not only determine the membrane characteristics but also evaluate one or several peritoneal dialysis exchange cycles in order to determine the best appropriate exchange cycle or series of cycles for the patient.
  • both automatic peritoneal dialysis sampling system and automatic peritoneal dialysis exchange system are similar systems which are synchronized and which are working with different software and fluidic connections.
  • they both may comprise peristaltic pumps.
  • the automatic peritoneal dialysis sampling system only consist of a series of electro-valves and containers, which electro-valves are controlled by the automatic peritoneal dialysis system.
  • the sampling is directed from the peritoneum to the containers by use of the drawing means of the automatic peritoneal dialysis system which contains a specific order-of sequence for the opening and closing of specific valves in connection with the peritoneal dialysis cycles.
  • the peritoneal dialysis system may comprise a memory key which contains all the necessary data to program the functioning of said automatic peritoneal dialysis sampling system according to the peritoneal dialysis cycles and to store the sampling information.
  • the automatic peritoneal dialysis sampling system may comprise means for sequentially collecting sample volumes in a tubing, each sample being separated from the previous one by an air bubble inserted by the automatic peritoneal sampling system in-between each sample.
  • sampling containers may preferably be enclosed inside a cooling box which comprises cooling means.
  • the automatic peritoneal dialysis sampling system comprises analyzing means for directly analyzing of at least one characteristic of the sample in-line, such as by spectroscopy, fluorometry or by use of chemical or electro-chemical means.
  • the automatic sampling system may be adapted to measure different constituents/parameters such as glucose, urea, creatinine, sodium, chloride, albumine, proteins, osmolarity or ph.
  • the result of the in-line analysis is used to optimize the next peritoneal dialysis exchange cycle or sampling intervals in order to improve the membrane characteristics evaluation or directly evaluate the impact of specific changes on the peritoneal dialysis outcome for the patient.
  • FIG. 1 illustrates a first embodiment of the system according to the invention where the automatic sampling system is connected on the draining line between the patient peritoneum and the draining means.
  • FIG. 2 illustrates another embodiment of the system according to the invention where the automatic sampling system is connected on the draining line between the draining means and a waste collector.
  • the peritoneal dialysis system according to FIG. 1 consists of a first system 1 comprising a first peristaltic pump 3 , dialysis fluid containers 4 , a line 6 , 7 consisting of a supplying/draining line 7 which is arranged between a patient 5 and the first peristaltic pump 3 and a draining line 6 which is arranged between the first peristaltic pump 3 and a first waste collector 10 , the dialysis fluid containers 4 and the draining line 6 may be alternatively connected to the supplying/draining line 7 by a valve 9 e.g. of electromechanical type.
  • a valve 9 e.g. of electromechanical type.
  • the supplying/draining line 7 is provided with a Y-site 24 in order to connect a sampling line 8 .
  • the peritoneal dialysis system according to FIG. 1 also include an automatic sampling system 2 made of a second peristaltic pump 11 , a collection line 12 , sampling containers 13 linked to the sampling line 8 via conduits 20 and a analyzing line 16 comprising an analyzing unit 15 .
  • the sampling line 8 , the conduits 20 , the analyzing line 16 and the collection line 12 are all alternatively connected to the second peristaltic pump 11 by an appropriate valve 19 .
  • the sampling containers 13 are arranged within a cooling container 14 .
  • Both first system 1 and the automatic sampling system 2 may change information via a communication line 18 (by cable or by wireless communication).
  • the automatic sampling system 2 is provided with a memory key 25 which contains all the necessary data to program the functioning of said automatic peritoneal dialysis sampling system and to store the sampling information.
  • the automatic sampling system 2 can be programmed to take volumic fractions of liquid at predetermined times, for instance during the dwell time. Those volumic fractions may differ from each others.
  • the volumic fractions may also be taken during the drain cycle.
  • the collection line 12 allows to purge a dead volume between samplings.
  • FIG. 2 shows another configuration, very similar to the configuration of FIG. 1 , but which uses only one peristaltic pump 3 for supplying dialysis liquid to the patient, draining dialysis fluid from the patient and supplying volumic fractions to the automatic sampling system 2 .
  • the sampling line 8 is connected on the draining line 6 .
  • sampling are controlled by the peristaltic pump which may be activated for sampling purposes at any time, including during the dwell time.

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • External Artificial Organs (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
US10/501,394 2002-01-28 2003-01-23 Peritoneal dialysis system Abandoned US20050089994A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US13/180,547 US9125989B2 (en) 2003-01-23 2011-07-12 Device for determining the characteristics of peritoneal membrane
US13/507,087 US9149571B2 (en) 2002-01-28 2012-06-04 Peritoneal dialysis system
US14/836,886 US9983101B2 (en) 2002-01-28 2015-08-26 Sampling system for performing an automatic dialysis sampling

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH0200046 2002-01-28
CHPCTCHO200046 2002-01-28
PCT/CH2003/000048 WO2003063929A1 (en) 2002-01-28 2003-01-23 Peritoneal dialysis system

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/CH2003/000048 A-371-Of-International WO2003063929A1 (en) 2002-01-28 2003-01-23 Peritoneal dialysis system

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US13/180,547 Continuation-In-Part US9125989B2 (en) 2002-01-28 2011-07-12 Device for determining the characteristics of peritoneal membrane
US13/507,087 Division US9149571B2 (en) 2002-01-28 2012-06-04 Peritoneal dialysis system

Publications (1)

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US20050089994A1 true US20050089994A1 (en) 2005-04-28

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Family Applications (2)

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US10/501,394 Abandoned US20050089994A1 (en) 2002-01-28 2003-01-23 Peritoneal dialysis system
US13/507,087 Expired - Fee Related US9149571B2 (en) 2002-01-28 2012-06-04 Peritoneal dialysis system

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US13/507,087 Expired - Fee Related US9149571B2 (en) 2002-01-28 2012-06-04 Peritoneal dialysis system

Country Status (6)

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US (2) US20050089994A1 (ja)
EP (1) EP1469896B1 (ja)
JP (1) JP4303125B2 (ja)
AT (1) ATE479456T1 (ja)
DE (1) DE60333983D1 (ja)
WO (1) WO2003063929A1 (ja)

Cited By (18)

* Cited by examiner, † Cited by third party
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US20090275881A1 (en) * 2008-05-02 2009-11-05 Baxter International Inc. Optimizing therapy outcomes for peritoneal dialysis
US20100198138A1 (en) * 2009-01-30 2010-08-05 Baxter International Inc. Transfer sets for therapy optimization
US20100217178A1 (en) * 2009-02-20 2010-08-26 Baxter International Inc. Prediction of peritoneal dialysis therapy outcomes using dialysates mixed at different glucose concentrations
US20100298662A1 (en) * 2009-05-20 2010-11-25 Baxter International Inc. System and method for automated data collection of twenty-four hour ultrafiltration and other patient parameters using wired or wireless technology
US20110010101A1 (en) * 2009-07-07 2011-01-13 Baxter International Inc. Simplified peritoneal equilibration test for peritoneal dialysis
US20110093294A1 (en) * 2009-10-16 2011-04-21 Baxter International Inc. Peritoneal dialysis optimized using a patient hand-held scanning device
US7934912B2 (en) 2007-09-27 2011-05-03 Curlin Medical Inc Peristaltic pump assembly with cassette and mounting pin arrangement
US8062008B2 (en) 2007-09-27 2011-11-22 Curlin Medical Inc. Peristaltic pump and removable cassette therefor
US8083503B2 (en) 2007-09-27 2011-12-27 Curlin Medical Inc. Peristaltic pump assembly and regulator therefor
CN102458500A (zh) * 2009-06-05 2012-05-16 弗雷森纽斯医疗护理德国有限责任公司 用于收集样品的装置
WO2012127513A1 (en) * 2011-03-24 2012-09-27 Arnaldi E Gaetani Associati S.R.L. Device for management and sampling of dialysis fluids for use with systems of the cgms type (continuous glucose monitoring systems) and the like
US8871095B2 (en) 2008-07-09 2014-10-28 Baxter International Inc. Dialysis method including wireless patient data
US8882700B2 (en) 2008-05-02 2014-11-11 Baxter International Inc. Smart patient transfer set for peritoneal dialysis
US9649436B2 (en) 2011-09-21 2017-05-16 Bayer Healthcare Llc Assembly method for a fluid pump device for a continuous multi-fluid delivery system
US9861733B2 (en) 2012-03-23 2018-01-09 Nxstage Medical Inc. Peritoneal dialysis systems, devices, and methods
US9907897B2 (en) 2011-03-23 2018-03-06 Nxstage Medical, Inc. Peritoneal dialysis systems, devices, and methods
US10507319B2 (en) 2015-01-09 2019-12-17 Bayer Healthcare Llc Multiple fluid delivery system with multi-use disposable set and features thereof
US11207454B2 (en) 2018-02-28 2021-12-28 Nxstage Medical, Inc. Fluid preparation and treatment devices methods and systems

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JP4848143B2 (ja) * 2005-06-17 2011-12-28 テルモ株式会社 血液成分採取装置
US8449495B2 (en) 2008-05-28 2013-05-28 Baxter Healthcare Inc. Dialysis system having automated effluent sampling and peritoneal equilibration test
US9514283B2 (en) * 2008-07-09 2016-12-06 Baxter International Inc. Dialysis system having inventory management including online dextrose mixing
JP5548917B2 (ja) * 2009-04-23 2014-07-16 ニプロ株式会社 毒素除去量測定装置の作動方法およびサンプリング装置
US8926551B2 (en) 2009-07-07 2015-01-06 Baxter Healthcare Inc. Peritoneal dialysis therapy with large dialysis solution volumes
EP2510958B2 (en) * 2011-04-11 2023-02-15 Fresenius Medical Care Deutschland GmbH Method and apparatus for monitoring a treatment of a patient, preferably for monitoring hemodialysis, hemodiafiltration and/or peritoneal dialysis
ITMO20120021A1 (it) * 2012-02-01 2013-08-02 Fabio Grandi Metodo e sistema di dialisi peritoneale
EP2674103A1 (en) 2012-06-15 2013-12-18 Fresenius Medical Care Deutschland GmbH Method and device for monitoring an extracorporeal blood treatment of a patient
WO2016080883A1 (en) 2014-11-21 2016-05-26 Triomed Ab Apparatus for performing peritoneal ultrafiltration
JP7472297B2 (ja) * 2020-01-30 2024-04-22 フレセニウス メディカル ケア ホールディングス インコーポレーテッド 透析患者プロファイルを決定するための技法

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Cited By (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7934912B2 (en) 2007-09-27 2011-05-03 Curlin Medical Inc Peristaltic pump assembly with cassette and mounting pin arrangement
US8062008B2 (en) 2007-09-27 2011-11-22 Curlin Medical Inc. Peristaltic pump and removable cassette therefor
US8083503B2 (en) 2007-09-27 2011-12-27 Curlin Medical Inc. Peristaltic pump assembly and regulator therefor
US20090275881A1 (en) * 2008-05-02 2009-11-05 Baxter International Inc. Optimizing therapy outcomes for peritoneal dialysis
US9348975B2 (en) 2008-05-02 2016-05-24 Baxter International Inc. Optimizing therapy outcomes for peritoneal dialysis
US8882700B2 (en) 2008-05-02 2014-11-11 Baxter International Inc. Smart patient transfer set for peritoneal dialysis
US8871095B2 (en) 2008-07-09 2014-10-28 Baxter International Inc. Dialysis method including wireless patient data
US10307524B2 (en) 2008-07-09 2019-06-04 Baxter International Inc. Dialysis method and system including wireless patient data
US10272190B2 (en) 2008-07-09 2019-04-30 Baxter International Inc. Renal therapy system including a blood pressure monitor
US10265455B2 (en) 2008-07-09 2019-04-23 Baxter International Inc. Dialysis system including wireless sensor data
US10016554B2 (en) 2008-07-09 2018-07-10 Baxter International Inc. Dialysis system including wireless patient data
US8636706B2 (en) 2009-01-30 2014-01-28 Baxter International Inc. Transfer sets for therapy optimization
US8377012B2 (en) 2009-01-30 2013-02-19 Baxter International Inc. Transfer sets for therapy optimization
US20100198138A1 (en) * 2009-01-30 2010-08-05 Baxter International Inc. Transfer sets for therapy optimization
US20100217178A1 (en) * 2009-02-20 2010-08-26 Baxter International Inc. Prediction of peritoneal dialysis therapy outcomes using dialysates mixed at different glucose concentrations
US11027053B2 (en) 2009-05-20 2021-06-08 Baxter International Inc. Method for pairing a dialysis machine with peripheral devices
US10314958B2 (en) 2009-05-20 2019-06-11 Baxter International Inc. System and method for pairing a dialysis machine with peripheral devices
US11752245B2 (en) 2009-05-20 2023-09-12 Baxter International Inc. System and method for automated collection of dialysis data
US9381290B2 (en) 2009-05-20 2016-07-05 Baxter International Inc. System and method for pairing a dialysis machine with peripheral devices
US20100298662A1 (en) * 2009-05-20 2010-11-25 Baxter International Inc. System and method for automated data collection of twenty-four hour ultrafiltration and other patient parameters using wired or wireless technology
US8282829B2 (en) 2009-05-20 2012-10-09 Baxter International Inc. System and method for automated data collection of twenty-four hour ultrafiltration and other patient parameters using wired or wireless technology
CN102458500A (zh) * 2009-06-05 2012-05-16 弗雷森纽斯医疗护理德国有限责任公司 用于收集样品的装置
US20110010101A1 (en) * 2009-07-07 2011-01-13 Baxter International Inc. Simplified peritoneal equilibration test for peritoneal dialysis
US8180574B2 (en) * 2009-07-07 2012-05-15 Baxter International Simplified peritoneal equilibration test for peritoneal dialysis
US20110093294A1 (en) * 2009-10-16 2011-04-21 Baxter International Inc. Peritoneal dialysis optimized using a patient hand-held scanning device
US11058809B2 (en) 2009-10-16 2021-07-13 Baxter International Inc. Optimizing peritoneal dialysis using a patient hand-held scanning device
US10449284B2 (en) 2009-10-16 2019-10-22 Baxter Interntional Inc. Optimizing peritoneal dialysis using a patient hand-held scanning device
US11607479B2 (en) 2009-10-16 2023-03-21 Baxter International Inc. Optimizing peritoneal dialysis using a patient hand-held scanning device
US9020827B2 (en) 2009-10-16 2015-04-28 Baxter International Inc. Peritoneal dialysis optimized using a patient hand-held scanning device
US9907897B2 (en) 2011-03-23 2018-03-06 Nxstage Medical, Inc. Peritoneal dialysis systems, devices, and methods
US11690941B2 (en) 2011-03-23 2023-07-04 Nxstage Medical, Inc. Peritoneal dialysis systems, devices, and methods
US10046100B2 (en) 2011-03-23 2018-08-14 Nxstage Medical, Inc. Peritoneal dialysis systems, devices, and methods
US10603424B2 (en) 2011-03-23 2020-03-31 Nxstage Medical, Inc. Peritoneal dialysis systems, devices, and methods
US10610630B2 (en) 2011-03-23 2020-04-07 Nxstage Medical, Inc. Peritoneal dialysis systems, devices, and methods
US10688234B2 (en) 2011-03-23 2020-06-23 Nxstage Medical, Inc. Peritoneal dialysis systems, devices, and methods
US10688235B2 (en) 2011-03-23 2020-06-23 Nxstage Medical, Inc. Peritoneal dialysis systems, devices, and methods
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US20120310056A1 (en) 2012-12-06
ATE479456T1 (de) 2010-09-15
WO2003063929A1 (en) 2003-08-07
JP2005515845A (ja) 2005-06-02
JP4303125B2 (ja) 2009-07-29
DE60333983D1 (de) 2010-10-14

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