US20040232171A1 - Apparatus for delivering sensitive liquid media - Google Patents

Apparatus for delivering sensitive liquid media Download PDF

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Publication number
US20040232171A1
US20040232171A1 US10/835,992 US83599204A US2004232171A1 US 20040232171 A1 US20040232171 A1 US 20040232171A1 US 83599204 A US83599204 A US 83599204A US 2004232171 A1 US2004232171 A1 US 2004232171A1
Authority
US
United States
Prior art keywords
container
pressure
medium
chamber
pressure chamber
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10/835,992
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English (en)
Inventor
Benjamin Bobst
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Apotheker Vetter and Company Arzneimittel GmbH Ravensburg
Original Assignee
Apotheker Vetter and Company Arzneimittel GmbH Ravensburg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apotheker Vetter and Company Arzneimittel GmbH Ravensburg filed Critical Apotheker Vetter and Company Arzneimittel GmbH Ravensburg
Assigned to ARZNEIMITTEL GMBH APOTHEKER VETTER & CO. RAVENSBURG reassignment ARZNEIMITTEL GMBH APOTHEKER VETTER & CO. RAVENSBURG ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BOBST, BENJAMIN
Publication of US20040232171A1 publication Critical patent/US20040232171A1/en
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/148—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags
    • A61M5/1483—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags using flexible bags externally pressurised by fluid pressure
    • A61M5/1486—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags using flexible bags externally pressurised by fluid pressure the bags being substantially completely surrounded by fluid

Definitions

  • the invention relates to an apparatus for delivering sensitive liquid media from a sealed flexible container using a pressurized chamber in which the container is held.
  • a sensitive liquid medium is held in a flexible container with an outlet and from which medium is forced upon pressure being applied to the container. It is distinguished by providing a pressure chamber into which the flexible container filled with the liquid medium can be introduced.
  • a pressure source is connected to the pressure chamber, acts on the pressure chamber with a positive pressure and therefore compresses the flexible container. The medium is thereby driven out of the container. It is particularly advantageous that the pressure can be set very accurately and can be easily monitored.
  • the pressure cabinet 1 shown in the single Figure has an interior which serves as a pressure chamber 3 , into which there is introduced a flexible container 5 in which there is a sensitive liquid medium 7 .
  • the container 5 is preferably formed as a sterile disposable bag, which is therefore used only once, so the problems of cleaning and disinfection of the container which are associated with refilling are avoided.
  • the container 5 has an outlet 9 , from which a hose 11 exits.
  • the hose discharges the liquid medium 7 from the container 5 . Otherwise, the container 5 is closed off completely from the outside, so that the medium 7 cannot be contaminated.
  • the container 5 is suspended in the interior of the pressure cabinet 1 in a suitable way.
  • a conventional cutout 13 which is provided in a double-walled region of the container 5 , so that there no connection is provided between the liquid medium 7 and the outside.
  • Two hooks 15 which hold the container 5 securely in the interior of the pressure cabinet 1 , engage in the cutout 13 .
  • the hooks 15 can be fixed to a rear wall 25 of the pressure cabinet 1 , or else from the inside to the upper side wall 17 . It is merely critical that the container 5 is held in a desired position here, so that it does not kink the hose 11 on account of the inherent weight of the container.
  • the lower side wall 21 of the cabinet has a cutout 27 , which leads from the pressure chamber 3 to the outside and accommodates the hose 11 .
  • an elastic protective layer for example a rubber grommet 29 , prevents the hose 11 chafing through.
  • a door 31 Fitted to one side wall 23 , for example via hinges 33 and 35 , or the like, is a door 31 which when closed, closes off the pressure chamber 3 in a pressure-tight manner.
  • the door On its side facing the pressure chamber 3 , the door may be provided with a circumferential seal 37 , which interacts with the front sides of the side walls 17 , 19 , 21 and 23 to close off the pressure chamber 3 in a pressure-tight manner.
  • a protective layer 38 may again be provided, which holds the hose 11 securely in the cutout 27 without chafing through it.
  • a pressure connection 39 via which the pressure chamber 3 can be connected at 40 to a pressure source 42 .
  • the pressure source can place the pressure chamber 3 and therefore also the flexible container 5 under a positive pressure.
  • a pressure indicator 41 and a safety valve 43 are also provided on the side wall 19 .
  • the apparatus 1 can also be provided with a vibrating unit, to ensure that the medium 7 present in the container 5 can be kept continuously moving or during predeterminable time periods, in order to avoid settling of the substances present in the medium.
  • the vibrating unit can act directly on the container 5 and can be accommodated in the pressure chamber 3 .
  • the pressure cabinet 1 is preferably placed on a vibrating table 44 and therefore subjected in its entirety to a movement which acts on the medium 7 in the container 5 .
  • a sensitive medium for example a solution, dispersion or suspension, which should not be subjected to any mechanical loading as might be provided, for example, when the medium is pumped with a peristaltic pump.
  • the container 5 itself is at least in part of flexible material, so that a positive pressure acting on the container 5 acts on the liquid medium 7 inside the container and drives the medium out via the outlet 9 and the hose 11 .
  • the container 5 is introduced into the interior of the pressure cabinet 1 , that is into the pressure chamber 3 , and is preferably fixed to the hooks 15 .
  • the hose 11 is led through the cutout 27 , which is dimensioned such that the hose 11 is not crushed when the door 31 is closed.
  • the hose 11 may consist of a flexible material which closes off the cutout 27 in a pressure-tight manner.
  • a protective layer 29 which interacts with the protective layer 38 on the door 31 in such a way that, when the door is closed, the hose 11 is enclosed completely and the pressure chamber 3 is closed off pressure-tight from the outside.
  • the seal 37 interacts with the side walls 17 , 19 , 21 and 23 here, so that the pressure chamber 3 is closed off completely when the door 31 is closed.
  • a positive pressure is built up in the interior of the apparatus, here in the pressure cabinet 1 , through the pressure connection 39 .
  • a gaseous medium is preferably conducted into the pressure chamber 3 , since such a medium escapes quickly when the door 31 is opened.
  • it would also be conceivable to conduct a liquid medium into the chamber 3 since the pressure medium is isolated by the container 5 from the liquid medium 7 in the interior of the container.
  • Nitrogen is preferably conducted into the pressure chamber 3 from the source 42 , since would not impair the sensitive medium 7 in the interior of the container 5 , even in the event of any leaks in the container.
  • the inside of the pressure cabinet 1 is not contaminated by this gas.
  • the positive pressure acting in the pressure chamber 3 can be set by a monitoring device in terms of level and in terms of the pressure variation provided over time. For this purpose, suitable backing up of the pressure source can be provided. Monitoring of the pressure chamber 3 can be implemented by a monitoring device which includes the pressure indicator 41 and the safety valve 43 . The valve prevents a hazardous positive pressure in the pressure chamber 3 and therefore prevents the door 31 bursting open undesirably. However, it is particularly important that the medium 7 is discharged from the container 5 only at a defined pressure and that is non-hazardous for the medium 7 and for its processing.
  • the safety valve 43 preferably can be set to a desired pressure, in order to employ the apparatus readily for various delivery purposes. For example, when filtering sensitive media, a filtration pressure of about 0.2 bar is used. Accordingly, the safety valve 43 must then be set to this pressure, in order to enable use of the apparatus for filtering.
  • the pressure chamber 3 is designed to accommodate a single container 5 . However, it is possible to subdivide the pressure chamber and to allocate different pressure values to various regions of the pressure chamber which are delimited from one another in a pressure-tight manner, and also possible to accommodate different containers in these regions.
  • the pressure chamber 3 is not brought into contact with the medium 7 , so that the replacement of containers with different media is easily possible, without need for a complicated disinfection process.
  • the media from different containers do not come into contact with either the interior or the pressure chamber of the pressure cabinet nor with any appliances connected to the pressure chamber, here the pressure connection 39 , the pressure indicator 41 or the safety valve 43 .
  • the pressure chamber 3 is preferably acted on with nitrogen at a positive pressure, it is possible to ensure that the medium 7 is not impaired, even if the container 5 should have a leaky point and the pressure medium should penetrate into the interior of the container 5 .
  • the pressure connection 39 can also be provided with a pressure reducing valve. This leads to additional safety if the apparatus, for example, is used in a filtration in which a positive pressure of only 0.2 bar is desired.
  • the pressure cabinet 1 can be placed on conventional vibrating tables, which then act on the medium 7 with the vibrating movement. Since the pressure cabinet 1 is constructed very simply and ruggedly, no detriment to it are to be expected when a vibrating table is used.

Landscapes

  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Fluid Mechanics (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • External Artificial Organs (AREA)
US10/835,992 2003-05-03 2004-04-30 Apparatus for delivering sensitive liquid media Abandoned US20040232171A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10319874A DE10319874B3 (de) 2003-05-03 2003-05-03 Vorrichtung zum Fördern von empfindlichen, flüssigen Medien
DE10319874.1 2003-05-03

Publications (1)

Publication Number Publication Date
US20040232171A1 true US20040232171A1 (en) 2004-11-25

Family

ID=32731173

Family Applications (1)

Application Number Title Priority Date Filing Date
US10/835,992 Abandoned US20040232171A1 (en) 2003-05-03 2004-04-30 Apparatus for delivering sensitive liquid media

Country Status (5)

Country Link
US (1) US20040232171A1 (fr)
EP (1) EP1475112A1 (fr)
JP (1) JP2004329925A (fr)
CA (1) CA2465392A1 (fr)
DE (1) DE10319874B3 (fr)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050011582A1 (en) * 2003-06-06 2005-01-20 Haug Jeffrey S. Fluid delivery system for a flow cytometer
WO2006103489A1 (fr) * 2005-04-01 2006-10-05 Malak Jean Clement Edouard Ghi Dispositif d'injection de liquide medical par perfusion hyperbare
US20070167910A1 (en) * 2005-11-09 2007-07-19 Hyprotek, Inc. Syringe Devices, Components of Syringe Devices, and Methods of Forming Components and Syringe Devices
US20070265574A1 (en) * 2004-10-13 2007-11-15 Hyprotek, Inc. Syringe Devices and Methods for Mixing and Administering Medication
US8002737B2 (en) 2007-10-04 2011-08-23 Hyprotek, Inc. Mixing/administration syringe devices, protective packaging and methods of protecting syringe handlers
EP2842585A1 (fr) * 2013-09-02 2015-03-04 Remi Giordanengo Dispositif de gestion de fluides d'irrigation, en particulier pour l'endoscopie
CN104874048A (zh) * 2015-04-01 2015-09-02 上海司太立制药有限公司 软包装药液注射装置及注射方法
US9522097B2 (en) 2007-10-04 2016-12-20 Hyprotek, Inc. Mixing/administration syringe devices, protective packaging and methods of protecting syringe handlers
US10005575B2 (en) 2013-03-22 2018-06-26 Sartorius Stedim North America Inc. Facility and method for producing a container loaded with a biopharmaceutical fluid
US10031033B2 (en) 2013-03-22 2018-07-24 Sartorius Stedim North America Inc. Monitoring of the freezing state of a biopharmaceutical fluid found in a container
US20200093999A1 (en) * 2018-09-26 2020-03-26 Erbe Elektromedizin Gmbh Medical Instrument and Generation Device
CN113456928A (zh) * 2021-07-08 2021-10-01 广州友沃医疗设备有限公司 一种按压式高压注射器

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPR867901A0 (en) * 2001-11-05 2001-11-29 University of Newcastel Research Associates Limited, The 'Liquid dispenser'
DE102018103866A1 (de) * 2018-02-21 2019-08-22 Fresenius Medical Care Deutschland Gmbh Vorrichtung enthaltend eine Dialyseslösung

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5060826A (en) * 1988-08-25 1991-10-29 Fabricated Metals, Inc. Container with inflatable vessel for controlling flow of liquid or viscous material
US5497912A (en) * 1994-10-20 1996-03-12 Hoback; Michael W. Disposable self-dispensing pressurized package for delivery of sterile fluids
US5570628A (en) * 1992-03-18 1996-11-05 L+H Lemiteg Lebensmittel- Und Freizeittechnik Gmbh Hermetically sealed fresh-keeping container
US6027488A (en) * 1998-06-03 2000-02-22 Genetronics, Inc. Flow-through electroporation system for ex vivo gene therapy
US6074359A (en) * 1994-04-06 2000-06-13 Baxter International Inc. Method and apparatus for a tidal oscillating pulse peritoneal dialysis
US20010035184A1 (en) * 1999-12-17 2001-11-01 Carlos Schuler Systems and methods for treating packaged powders

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL180493C (nl) * 1977-09-02 1987-03-02 Oordt & Co Holding Bv Werkwijze voor het dubbelwandig, luchtdicht verpakken van levensmiddelen.
US5163909A (en) * 1991-01-28 1992-11-17 Alan E. Jordan Medical fluid delivery system
DE4137748A1 (de) * 1991-11-15 1993-05-19 Schiwa Gmbh Druckbehaelter zum druckbeaufschlagen eines mit einer pharmazeutischen fluessigkeit gefuellten beutels
GB2298933B (en) * 1992-07-13 1996-11-13 Pall Corp Automated system and method for processing biological fluid
EP0600754A3 (fr) * 1992-12-03 1995-05-24 Kato Hatsujo Kaisha Ltd Transfuseur pharmaceutique à débit continu.
IT1260685B (it) * 1993-09-29 1996-04-22 Sorin Biomedica Spa Dispositivo per il contenimento di sangue
US5792109A (en) * 1994-09-01 1998-08-11 Leland L. Ladd Irrigation pump and system
FR2750053B1 (fr) * 1996-06-21 1999-01-15 Saphir Medical Sa Generateur-distributeur bi-fonction de debit et/ou de pression

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5060826A (en) * 1988-08-25 1991-10-29 Fabricated Metals, Inc. Container with inflatable vessel for controlling flow of liquid or viscous material
US5570628A (en) * 1992-03-18 1996-11-05 L+H Lemiteg Lebensmittel- Und Freizeittechnik Gmbh Hermetically sealed fresh-keeping container
US6074359A (en) * 1994-04-06 2000-06-13 Baxter International Inc. Method and apparatus for a tidal oscillating pulse peritoneal dialysis
US5497912A (en) * 1994-10-20 1996-03-12 Hoback; Michael W. Disposable self-dispensing pressurized package for delivery of sterile fluids
US6027488A (en) * 1998-06-03 2000-02-22 Genetronics, Inc. Flow-through electroporation system for ex vivo gene therapy
US20010035184A1 (en) * 1999-12-17 2001-11-01 Carlos Schuler Systems and methods for treating packaged powders

Cited By (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050011582A1 (en) * 2003-06-06 2005-01-20 Haug Jeffrey S. Fluid delivery system for a flow cytometer
US8231567B2 (en) 2004-10-13 2012-07-31 Hyprotek, Inc. Syringe devices and methods for mixing and administering medication
US11376195B2 (en) 2004-10-13 2022-07-05 Hyprotek, Inc. Syringe devices and methods for mixing and administering medication
US20070265574A1 (en) * 2004-10-13 2007-11-15 Hyprotek, Inc. Syringe Devices and Methods for Mixing and Administering Medication
US7731678B2 (en) 2004-10-13 2010-06-08 Hyprotek, Inc. Syringe devices and methods for mixing and administering medication
US7731679B2 (en) 2004-10-13 2010-06-08 Hyprotek, Inc. Syringe devices and methods for mixing and administering medication
US7749189B2 (en) 2004-10-13 2010-07-06 Hyprotek, Inc. Syringe devices and methods for mixing and administering medication
US7753891B2 (en) 2004-10-13 2010-07-13 Hyprotek, Inc. Syringe devices and methods for mixing and administering medication
US7776011B2 (en) 2004-10-13 2010-08-17 Hyprotek, Inc. Syringe devices and methods for mixing and administering medication
US7985211B2 (en) 2004-10-13 2011-07-26 Hyprotek, Inc. Syringe devices and methods for mixing and administering medication
US9861555B2 (en) 2004-10-13 2018-01-09 Hyprotek, Inc. Syringe devices and methods for mixing and administering medication
WO2006103489A1 (fr) * 2005-04-01 2006-10-05 Malak Jean Clement Edouard Ghi Dispositif d'injection de liquide medical par perfusion hyperbare
US8608686B2 (en) 2005-11-09 2013-12-17 Hyprotek, Inc. Syringe devices, components of syringe devices, and methods of forming components and syringe devices
US20070167910A1 (en) * 2005-11-09 2007-07-19 Hyprotek, Inc. Syringe Devices, Components of Syringe Devices, and Methods of Forming Components and Syringe Devices
US8137307B2 (en) 2005-11-09 2012-03-20 Hyprotek, Inc. Syringe devices, components of syringe devices, and methods of forming components and syringe devices
US10485930B2 (en) 2005-11-09 2019-11-26 Hyprotek, Inc. Syringe devices, components of syringe devices, and methods of forming components and syringe devices
US8512278B2 (en) 2007-10-04 2013-08-20 Hyprotek, Inc. Mixing/administration syringe devices, protective packaging and methods of protecting syringe handlers
US9522097B2 (en) 2007-10-04 2016-12-20 Hyprotek, Inc. Mixing/administration syringe devices, protective packaging and methods of protecting syringe handlers
US8002737B2 (en) 2007-10-04 2011-08-23 Hyprotek, Inc. Mixing/administration syringe devices, protective packaging and methods of protecting syringe handlers
US10524983B2 (en) 2007-10-04 2020-01-07 Hyprotek, Inc. Mixing/administration syringe devices, protective packaging and methods of protecting syringe handlers
US10005575B2 (en) 2013-03-22 2018-06-26 Sartorius Stedim North America Inc. Facility and method for producing a container loaded with a biopharmaceutical fluid
US10031033B2 (en) 2013-03-22 2018-07-24 Sartorius Stedim North America Inc. Monitoring of the freezing state of a biopharmaceutical fluid found in a container
EP2842585A1 (fr) * 2013-09-02 2015-03-04 Remi Giordanengo Dispositif de gestion de fluides d'irrigation, en particulier pour l'endoscopie
FR3009964A1 (fr) * 2013-09-02 2015-03-06 Remi Giordanengo Dispositif de gestion de fluides d'irrigation, en particulier pour l'endoscopie.
CN104874048A (zh) * 2015-04-01 2015-09-02 上海司太立制药有限公司 软包装药液注射装置及注射方法
CN110946641A (zh) * 2018-09-26 2020-04-03 厄比电子医学有限责任公司 医疗仪器和产生装置
JP2020062390A (ja) * 2018-09-26 2020-04-23 エルベ エレクトロメディジン ゲーエムベーハーＥｒｂｅ Ｅｌｅｋｔｒｏｍｅｄｉｚｉｎ ＧｍｂＨ 医療器具および生成装置
US20200093999A1 (en) * 2018-09-26 2020-03-26 Erbe Elektromedizin Gmbh Medical Instrument and Generation Device
US11918733B2 (en) * 2018-09-26 2024-03-05 Erbe Elektromedizin Gmbh Medical instrument and aerosol generation device
JP7518607B2 (ja) 2018-09-26 2024-07-18 エルベ エレクトロメディジン ゲーエムベーハー 装置
CN113456928A (zh) * 2021-07-08 2021-10-01 广州友沃医疗设备有限公司 一种按压式高压注射器

Also Published As

Publication number Publication date
JP2004329925A (ja) 2004-11-25
DE10319874B3 (de) 2004-08-19
CA2465392A1 (fr) 2004-11-03
EP1475112A1 (fr) 2004-11-10

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Legal Events

Date Code Title Description
AS Assignment

Owner name: ARZNEIMITTEL GMBH APOTHEKER VETTER & CO. RAVENSBUR

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:BOBST, BENJAMIN;REEL/FRAME:015550/0319

Effective date: 20040513

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION