US20030199978A1 - Stable anterior chamber phakic lens - Google Patents

Stable anterior chamber phakic lens Download PDF

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Publication number
US20030199978A1
US20030199978A1 US10/124,648 US12464802A US2003199978A1 US 20030199978 A1 US20030199978 A1 US 20030199978A1 US 12464802 A US12464802 A US 12464802A US 2003199978 A1 US2003199978 A1 US 2003199978A1
Authority
US
United States
Prior art keywords
lens
optic
less
footplates
anterior chamber
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10/124,648
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English (en)
Inventor
Raymie Lindsey
James Scott
Stephen Van Noy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Inc
Original Assignee
Alcon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Inc filed Critical Alcon Inc
Priority to US10/124,648 priority Critical patent/US20030199978A1/en
Assigned to ALCON, INC. reassignment ALCON, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: LINDSEY, RAYMIE H., SCOTT, JAMES M., VAN NOY, STEPHEN J.
Priority to PCT/US2003/010101 priority patent/WO2003089958A2/en
Priority to SI200331758T priority patent/SI1494623T1/sl
Priority to MXPA04009074A priority patent/MXPA04009074A/es
Priority to BRPI0309285A priority patent/BRPI0309285B8/pt
Priority to DE60330447T priority patent/DE60330447D1/de
Priority to ES03746936T priority patent/ES2337674T3/es
Priority to AT03746936T priority patent/ATE451078T1/de
Priority to CA2479194A priority patent/CA2479194C/en
Priority to JP2003586639A priority patent/JP4339704B2/ja
Priority to PT03746936T priority patent/PT1494623E/pt
Priority to EP03746936A priority patent/EP1494623B1/en
Priority to DK03746936.8T priority patent/DK1494623T3/da
Priority to AU2003226205A priority patent/AU2003226205B2/en
Publication of US20030199978A1 publication Critical patent/US20030199978A1/en
Priority to US12/419,680 priority patent/US8317860B2/en
Priority to CY20101100205T priority patent/CY1109867T1/el
Abandoned legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16Intraocular lenses
    • A61F2/1613Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1616Pseudo-accommodative, e.g. multifocal or enabling monovision
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16Intraocular lenses
    • A61F2/1602Corrective lenses for use in addition to the natural lenses of the eyes or for pseudo-phakic eyes
    • A61F2/1605Anterior chamber lenses for use in addition to the natural lenses of the eyes, e.g. iris fixated, iris floating

Definitions

  • This invention relates generally to the field of intraocular lenses (IOL) and, more particularly, to anterior chamber phakic IOLs.
  • IOL intraocular lenses
  • the human eye in its simplest terms functions to provide vision by transmitting light through a clear outer portion called the cornea, and focusing the image by way of a crystalline lens onto a retina.
  • the quality of the focused image depends on many factors including the size and shape of the eye, and the transparency of the cornea and the lens.
  • the optical power of the eye is determined by the optical power of the cornea and the crystalline lens.
  • sharp images are formed on the retina (emmetropia).
  • images are either formed in front of the retina because the eye is abnormally long (axial myopia), or formed in back of the retina because the eye is abnormally short (axial hyperopia).
  • the cornea also may be asymmetric or toric, resulting in an uncompensated cylindrical refractive error referred to as corneal astigmatism.
  • the eye may become presbyopic resulting in the need for a bifocal or multifocal correction device.
  • photablative lasers to reshape the surface of the cornea (photorefractive keratectomy or PRK) or for mid-stromal photoablation (Laser-Assisted In Situ Keratomileusis or LASIK) have been approved by regulatory authorities in the U.S. and other countries. All of these refractive surgical procedures cause an irreversible modification to the shape of the cornea in order to effect refractive changes, and if the correct refraction is not achieved by the first procedure, a second procedure or enhancement must be performed. Additionally, the long-term stability of the correction is variable because of the variability of the biological wound healing response between patients.
  • Keravision owns a series of patents related to an intrastromal ring device used to induce refractive changes in the cornea (see U.S. Pat. Nos. 5,505,722, 5,466,260, 5,405,384, 5,323,788, 5,318,047, 5312,424, 5,300,118, 5,188,125, 4,766,895, 4,671,276 and 4,452,235).
  • the use of a ring-shaped device avoids implantation of the device within the central optical zone of the cornea, and is implanted in peripheral groove made by a special surgical instrument.
  • the ring itself has no refractive power. Refractive changes are caused by the implanted ring changing the shape of the anterior surface of the cornea.
  • GAK Gel Injection Adjustable Keratoplasty
  • these publications disclose injecting a ring of biocompatible gel around the optic zone of the stroma to effect refractive changes to the cornea by changing the shape of the cornea.
  • the present invention improves upon the prior art by providing an anterior chamber phakic lens made from a foldable, highly biocompatible material that has a very low haptic compression force and low axial displacement, yet is stable in the anterior chamber.
  • one objective of the present invention is to provide a safe and biocompatible intraocular lens.
  • Another objective of the present invention is to provide a safe and biocompatible intraocular lens with a very low haptic compression force.
  • Still another objective of the present invention is to provide a safe and biocompatible intraocular lens that is stable in the anterior chamber.
  • FIG. 1 is a top perspective view of one lens suitable for practicing the teachings of the present invention.
  • FIG. 2 is a top plan view of one lens suitable for practicing the teachings of the present invention.
  • FIG. 3 is a side elevational view of one lens suitable for practicing the teachings of the present invention.
  • Prior art anterior chamber lenses have generally been made from polymethyl methacrylate (PMMA), which is a relatively hard thermoplastic. Prior to the present invention, a certain amount of rigidity was believed necessary to maintain stability of the implant in the anterior chamber. See also U.S. Pat. No. 6,228,115 (Hoffmann, et al.), the entire contents of which being incorporated herein by reference, wherein a stiffening element is added to the haptic to achieve the desirable stability of the lens. The inventors of the present invention have discovered that the compressive forces of PMMA anterior chamber lenses is far in excess of what is required for stability. Recent advances in biocompatible materials makes it possible to construct anterior chamber lenses from soft materials such as silicones, hydrogels and soft acrylics. With these softer materials, there is some question as to the stability of the implant in the anterior chamber. The inventors of the present invention have discovered that lenses made from soft material are stable when certain compressive forces and contact areas are used.
  • PMMA polymethyl methacrylate
  • the commercially available Bausch & Lomb NuVita Model MA 20 exhibits a force response of approximately 2.7 mN at 1 mm of compression when measured according to the industry standard compression test, ISO/DIS 11979-3.
  • the IOL illustrated in FIGS. 1 - 3 exhibits a force response of less than approximately 0.5 mN at 1 mm of compression when made from a soft acrylic material, which is similar to the commercially available Alcon Model SA30EL posterior chamber lens.
  • the broad haptic contact areas found on posterior chamber IOLs such as the Alcon Model SA30EL are not suitable for implantation in the anterior chamber because such designs can cause translational movement of the haptic contact points relative to the anterior chamber tissue, resulting in chronic irritation and the formation of synechia.
  • IOL 10 meets the design requirement of the present invention.
  • IOL 10 is preferably made in a single piece entirely from a soft acrylic, such as those described in U.S. Pat. Nos. 5,290,892, 5,403,901, 5433746, 5,674,960 and 5,861,031 (Namong, et al.) and 5,693,095 (Freeman, et al.), the entire contents of which being incorporated herein by reference.
  • a soft acrylic such as those described in U.S. Pat. Nos. 5,290,892, 5,403,901, 5433746, 5,674,960 and 5,861,031 (Namong, et al.) and 5,693,095 (Freeman, et al.), the entire contents of which being incorporated herein by reference.
  • Such a material allows IOL 10 to be rolled or folded so as to fit through a 3.5 mm or less surgical incision and implanted in the anterior chamber of an eye.
  • IOL 10 may also be made from a soft
  • IOL 10 generally contains two opposing pairs of footplates 12 joined to optic 14 by haptics 16 and ramps 18 .
  • Optic 14 may have any suitable diameter, but is preferably between 5.0 mm and 6.0 mm.
  • Footplates 12 are separated by haptic 16 by a distance S, that is preferably less than 1.5 times the diameter of optic 14 , and most preferably around 1.3 times the diameter of optic 14 .
  • Footplates 12 and haptics 16 preferably are between 0.20 and 0.30 mm thick, which provides sufficient compressive force, while minimizing axial vaulting of lens 10 to less than 1.5 mm and preferably less than 1.0 mm when footplates 12 and haptics 16 are compressed 1 mm.
  • IOL 10 exhibits a force response of approximately less than 0.5 mN, and more preferably, approximately less than 0.3 mN, when IOL 10 is compressed 1 mm according to industry standard test ISO/DIS 11979-3.

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  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)
  • Non-Portable Lighting Devices Or Systems Thereof (AREA)
  • Optical Couplings Of Light Guides (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
US10/124,648 2002-04-17 2002-04-17 Stable anterior chamber phakic lens Abandoned US20030199978A1 (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
US10/124,648 US20030199978A1 (en) 2002-04-17 2002-04-17 Stable anterior chamber phakic lens
AU2003226205A AU2003226205B2 (en) 2002-04-17 2003-04-01 Stable anterior chamber phakic lens
CA2479194A CA2479194C (en) 2002-04-17 2003-04-01 Stable anterior chamber phakic lens
PT03746936T PT1494623E (pt) 2002-04-17 2003-04-01 Lente fáquica estável para câmara anterior
MXPA04009074A MXPA04009074A (es) 2002-04-17 2003-04-01 Lente faquico de camara anterior estable.
BRPI0309285A BRPI0309285B8 (pt) 2002-04-17 2003-04-01 lente intraocular facóide de câmara anterior.
DE60330447T DE60330447D1 (pt) 2002-04-17 2003-04-01
ES03746936T ES2337674T3 (es) 2002-04-17 2003-04-01 Lente faquica de camara anterior estable.
AT03746936T ATE451078T1 (de) 2002-04-17 2003-04-01 Phakische linse für eine stabile aussenkammer
PCT/US2003/010101 WO2003089958A2 (en) 2002-04-17 2003-04-01 Stable anterior chamber phakic lens
JP2003586639A JP4339704B2 (ja) 2002-04-17 2003-04-01 安定な前眼房フェイキックレンズ
SI200331758T SI1494623T1 (sl) 2002-04-17 2003-04-01 Stabilna fakiŽŤna leŽŤa za anteriorno komoro
EP03746936A EP1494623B1 (en) 2002-04-17 2003-04-01 Stable anterior chamber phakic lens
DK03746936.8T DK1494623T3 (da) 2002-04-17 2003-04-01 Stabil phakic forkammerlinse
US12/419,680 US8317860B2 (en) 2002-04-17 2009-04-07 Stable anterior chamber phakic lenses
CY20101100205T CY1109867T1 (el) 2002-04-17 2010-03-03 Σταθερος φυσικος φακος του προσθιου θαλαμου

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/124,648 US20030199978A1 (en) 2002-04-17 2002-04-17 Stable anterior chamber phakic lens

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/419,680 Continuation US8317860B2 (en) 2002-04-17 2009-04-07 Stable anterior chamber phakic lenses

Publications (1)

Publication Number Publication Date
US20030199978A1 true US20030199978A1 (en) 2003-10-23

Family

ID=29214628

Family Applications (2)

Application Number Title Priority Date Filing Date
US10/124,648 Abandoned US20030199978A1 (en) 2002-04-17 2002-04-17 Stable anterior chamber phakic lens
US12/419,680 Expired - Lifetime US8317860B2 (en) 2002-04-17 2009-04-07 Stable anterior chamber phakic lenses

Family Applications After (1)

Application Number Title Priority Date Filing Date
US12/419,680 Expired - Lifetime US8317860B2 (en) 2002-04-17 2009-04-07 Stable anterior chamber phakic lenses

Country Status (15)

Country Link
US (2) US20030199978A1 (pt)
EP (1) EP1494623B1 (pt)
JP (1) JP4339704B2 (pt)
AT (1) ATE451078T1 (pt)
AU (1) AU2003226205B2 (pt)
BR (1) BRPI0309285B8 (pt)
CA (1) CA2479194C (pt)
CY (1) CY1109867T1 (pt)
DE (1) DE60330447D1 (pt)
DK (1) DK1494623T3 (pt)
ES (1) ES2337674T3 (pt)
MX (1) MXPA04009074A (pt)
PT (1) PT1494623E (pt)
SI (1) SI1494623T1 (pt)
WO (1) WO2003089958A2 (pt)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040034417A1 (en) * 2002-08-16 2004-02-19 Heyman Thomas M. Intraocular lens
US20070021832A1 (en) * 2004-08-24 2007-01-25 Nordan Lee T Foldable intraocular lens with adaptable haptics
US20080086208A1 (en) * 2004-08-24 2008-04-10 Nordan T Lee Foldable Intraocular Lens With Adaptable Haptics
WO2011020078A1 (en) 2009-08-13 2011-02-17 Acufocus, Inc. Masked intraocular implants and lenses
US7926940B2 (en) 2007-02-23 2011-04-19 Pixeloptics, Inc. Advanced electro-active optic device
US8215770B2 (en) 2007-02-23 2012-07-10 E-A Ophthalmics Ophthalmic dynamic aperture
US8778022B2 (en) * 2004-11-02 2014-07-15 E-Vision Smart Optics Inc. Electro-active intraocular lenses
US8915588B2 (en) 2004-11-02 2014-12-23 E-Vision Smart Optics, Inc. Eyewear including a heads up display
US9122083B2 (en) 2005-10-28 2015-09-01 E-Vision Smart Optics, Inc. Eyewear docking station and electronic module
US9155614B2 (en) 2007-01-22 2015-10-13 E-Vision Smart Optics, Inc. Flexible dynamic electro-active lens
US9801709B2 (en) 2004-11-02 2017-10-31 E-Vision Smart Optics, Inc. Electro-active intraocular lenses

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG155247A1 (en) * 2004-08-24 2009-09-30 Vision Membrane Technologies I Foldable intraocular lens with adaptable haptics

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Cited By (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040034417A1 (en) * 2002-08-16 2004-02-19 Heyman Thomas M. Intraocular lens
US20070021832A1 (en) * 2004-08-24 2007-01-25 Nordan Lee T Foldable intraocular lens with adaptable haptics
US20080086208A1 (en) * 2004-08-24 2008-04-10 Nordan T Lee Foldable Intraocular Lens With Adaptable Haptics
US10126569B2 (en) 2004-11-02 2018-11-13 E-Vision Smart Optics Inc. Flexible electro-active lens
US10353429B2 (en) 2004-11-02 2019-07-16 E-Vision Smart Optics, Inc. Eyewear systems
US10172704B2 (en) 2004-11-02 2019-01-08 E-Vision Smart Optics, Inc. Methods and apparatus for actuating an ophthalmic lens in response to ciliary muscle motion
US8778022B2 (en) * 2004-11-02 2014-07-15 E-Vision Smart Optics Inc. Electro-active intraocular lenses
US8915588B2 (en) 2004-11-02 2014-12-23 E-Vision Smart Optics, Inc. Eyewear including a heads up display
US8931896B2 (en) 2004-11-02 2015-01-13 E-Vision Smart Optics Inc. Eyewear including a docking station
US10795411B2 (en) 2004-11-02 2020-10-06 E-Vision Smart Optics, Inc. Eyewear including a remote control camera and a docking station
US9124796B2 (en) 2004-11-02 2015-09-01 E-Vision Smart Optics, Inc. Eyewear including a remote control camera
US10159563B2 (en) 2004-11-02 2018-12-25 E-Vision Smart Optics, Inc. Eyewear including a detachable power supply and a display
US9801709B2 (en) 2004-11-02 2017-10-31 E-Vision Smart Optics, Inc. Electro-active intraocular lenses
US11822155B2 (en) 2004-11-02 2023-11-21 E-Vision Smart Optics, Inc. Eyewear including a remote control camera
US10092395B2 (en) 2004-11-02 2018-10-09 E-Vision Smart Optics, Inc. Electro-active lens with crossed linear electrodes
US10729539B2 (en) 2004-11-02 2020-08-04 E-Vision Smart Optics, Inc. Electro-chromic ophthalmic devices
US11422389B2 (en) 2004-11-02 2022-08-23 E-Vision Smart Optics, Inc. Eyewear including a remote control camera
US12066695B2 (en) 2004-11-02 2024-08-20 E-Vision Smart Optics, Inc. Ophthalmic systems and methods with lateral focus shifting
US11262796B2 (en) 2004-11-02 2022-03-01 E-Vision Smart Optics, Inc. Eyewear including a detachable power supply and display
US10852766B2 (en) 2004-11-02 2020-12-01 E-Vision Smart Optics, Inc. Electro-active elements with crossed linear electrodes
US10379575B2 (en) 2004-11-02 2019-08-13 E-Vision Smart Optics, Inc. Eyewear including a remote control camera and a docking station
US11144090B2 (en) 2004-11-02 2021-10-12 E-Vision Smart Optics, Inc. Eyewear including a camera or display
US10114235B2 (en) 2005-10-28 2018-10-30 E-Vision Smart Optics, Inc. Eyewear docking station and electronic module
US9122083B2 (en) 2005-10-28 2015-09-01 E-Vision Smart Optics, Inc. Eyewear docking station and electronic module
US9155614B2 (en) 2007-01-22 2015-10-13 E-Vision Smart Optics, Inc. Flexible dynamic electro-active lens
US11474380B2 (en) 2007-01-22 2022-10-18 E-Vision Smart Optics, Inc. Flexible electro-active lens
US8215770B2 (en) 2007-02-23 2012-07-10 E-A Ophthalmics Ophthalmic dynamic aperture
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JP4339704B2 (ja) 2009-10-07
CA2479194A1 (en) 2003-10-30
BR0309285B1 (pt) 2013-04-24
EP1494623A2 (en) 2005-01-12
US8317860B2 (en) 2012-11-27
WO2003089958A3 (en) 2004-10-14
WO2003089958A2 (en) 2003-10-30
PT1494623E (pt) 2010-03-05
CA2479194C (en) 2010-06-15
ATE451078T1 (de) 2009-12-15
EP1494623B1 (en) 2009-12-09
BRPI0309285B8 (pt) 2021-06-22
AU2003226205B2 (en) 2007-07-12
US20090248153A1 (en) 2009-10-01
ES2337674T3 (es) 2010-04-28
AU2003226205A1 (en) 2003-11-03
SI1494623T1 (sl) 2010-04-30
DK1494623T3 (da) 2010-04-06
DE60330447D1 (pt) 2010-01-21
EP1494623A4 (en) 2006-04-05
CY1109867T1 (el) 2014-09-10
MXPA04009074A (es) 2004-12-06
JP2005523095A (ja) 2005-08-04
BR0309285A (pt) 2005-02-09

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