US20030121878A1 - Versatile vial and plug system - Google Patents

Versatile vial and plug system Download PDF

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Publication number
US20030121878A1
US20030121878A1 US10/320,981 US32098102A US2003121878A1 US 20030121878 A1 US20030121878 A1 US 20030121878A1 US 32098102 A US32098102 A US 32098102A US 2003121878 A1 US2003121878 A1 US 2003121878A1
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United States
Prior art keywords
vial
plug
versatile
combination
recited
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10/320,981
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English (en)
Inventor
James Finneran
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
JG Finneran Associates inc
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Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to US10/320,981 priority Critical patent/US20030121878A1/en
Priority to EP02028893A priority patent/EP1325875A3/de
Assigned to J.G. FINNERAN ASSOCIATES, INC. reassignment J.G. FINNERAN ASSOCIATES, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: FINNERAN, JAMES G.
Publication of US20030121878A1 publication Critical patent/US20030121878A1/en
Abandoned legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B01L3/50825—Closing or opening means, corks, bungs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D39/00—Closures arranged within necks or pouring openings or in discharge apertures, e.g. stoppers
    • B65D39/0005—Closures arranged within necks or pouring openings or in discharge apertures, e.g. stoppers made in one piece
    • B65D39/0023—Plastic cap-shaped hollow plugs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D39/00—Closures arranged within necks or pouring openings or in discharge apertures, e.g. stoppers
    • B65D39/04—Cup-shaped plugs or like hollow flanged members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1406—Septums, pierceable membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/042—Caps; Plugs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0858—Side walls
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/24—Automatic injection systems

Definitions

  • the present invention relates generally to vial and closure systems and, more particularly, to those systems used in laboratory analytical techniques.
  • these types of systems require a securely sealed closure or cap having a penetrable segment for introduction or withdrawal of material to or from a vial or container on which the cap is mounted.
  • Such systems also require robotic engagement of the vial.
  • Chromatograghy is a laboratory technique for the separation and identification of chemical compounds in complex mixtures. Basically, it involves the flow of a mobile (gas or liquid) phase over a stationary phase (which may be a solid or a liquid). Liquid chromatograghy is used for soluble substances and gas (vapor phase) chromatograghy for volatile substances. As the mobile phase moves past the stationary phase, repeated adsorption and desorption of the solute occurs at a rate determined chiefly by its ratio of distribution between the two phases. If the ratio is large enough, the components of the mixture will move at different rates, producing a characteristic pattern, or chromatogragh, from which their identity can be determined.
  • the snap cap and container are typically made of plastic. This is advantageous because metal is undesirable in laboratory settings.
  • the seal is consistent and provides an adequate short-term (about 8 hours) seal against solvent evaporation. Because the materials used to form the cap and container are not very rigid, however, the designs cannot provide a seal able to withstand contents under high pressure or provide for long-term storage without leakage. The characteristics of the snap cap design have limited use of that design in the chromatograghy market.
  • the first system 100 B includes a crimp cap 102 B and a vial 104 B as illustrated in FIG. 1B.
  • the crimp cap 102 B is securely retained on the neck finish 106 B of the (usually glass) vial 104 B by crimping a metallic (usually aluminum) skirt 108 B under a lip 110 B on the neck of the vial 104 B.
  • One advantage of the aluminum crimp cap 102 B is that it works on containers having either a standard crimp seal or a snap ring.
  • the neck finish 106 B of the vial 104 B has a robotic arm pick up area 120 B adapted for engagement by automatic equipment.
  • a disadvantage is that the ID of the vial 104 B at its top is relatively small, rendering it somewhat difficult to fill the vial 104 B using, for example and as illustrated in FIG. 2B, a pipette 150 .
  • Another disadvantage is that the aluminum crimp cap 102 B requires the use of a crimping tool to form a seal. The seal is subject to the amount of squeeze and alignment given by the user. When properly applied, however, the aluminum crimp cap 102 B provides a good seal against solvent evaporation.
  • Still another common closure system 100 C for containers involves a standard screw thread neck finish 106 C on a threaded vial 104 C and a corresponding screw thread on a threaded cap 102 C. Closure is attained and a seal obtained by twisting or rotating the threaded cap 102 C onto the threads 108 C of threaded vial 104 C, as illustrated in FIG. 1C.
  • screw thread closures require finger torque pressure to apply and remove the threaded cap 102 C.
  • the seal is subject to the amount of torque applied by the user. When torqued properly, the threaded cap 102 C provides a good seal although not equivalent to the aluminum crimp seal.
  • the neck finish 106 C of the threaded vial 104 C has a robotic arm pick up area 120 C adapted for engagement by automatic equipment.
  • One drawback is, however, that the threaded cap 102 C can lose torque upon relaxation of the plastic material, from which the typical threaded cap 102 C is made, which allows the threaded cap 102 C to back off the screw thread 108 C.
  • the threaded cap 102 C can only be used on threaded vials 104 C.
  • a disadvantage is that the ID of the threaded vial 104 C at its top is relatively small, rendering it somewhat difficult to fill the vial using, for example and as illustrated in FIG. 2C, a pipette 150 .
  • a vial and closure system 100 D especially well adapted for use in the chromatograghy market is the combination of a plastic or glass shell vial 104 D and a plastic plug 102 D.
  • the shell vial 104 D is a simple cylindrical shell, having a substantially constant ID and OD along its entire length. This configuration offers advantages and disadvantages.
  • the shell vial 104 D is not adapted for engagement by automatic equipment; it does not have a robotic arm pick up area.
  • the ID of the top opening of the shell vial 104 D is relatively large, facilitating the process of filling the shell vial 104 D using, for example and as illustrated in FIG. 2D, a pipette 150 .
  • the shell vial 104 D is also sealed easily and effectively by pushing the plug 102 D into the top opening of the shell vial 104 D.
  • An object of the present invention is to provide a versatile vial and plug system.
  • a related object is to provide a vial and closure system that can function with robotic analytical instruments.
  • Another object is to provide a system having relatively easy filling (pipetting), filtering, and capping characteristics.
  • the present invention provides a versatile vial and plug combination adapted to form a securely sealed closure of the vial.
  • the combination includes a vial with (a) a head defining a first chamber with a first inner diameter and a first outer diameter and extending between a top, with a center opening, and a lower shoulder, (b) a body defining a second chamber with a second inner diameter substantially equal to the first inner diameter and a second outer diameter substantially equal to the first outer diameter and extending between a base and an upper shoulder, and (c) a neck having an inner diameter less than the first inner diameter and an outer diameter less than the first outer diameter and extending between the lower shoulder of the head and the upper shoulder of the body, providing a recessed robotic arm pick up area adapted for engagement by automatic equipment.
  • the combination also includes a resilient plug with (a) an inwardly tapered base, (b) a top flange, and (c) a body extending from the base to the top flange and having an outer diameter that corresponds to or is only slightly greater than the first inner diameter of the vial, assuring an interference fit between the plug and the vial, thereby sealing the plug inside the vial upon insertion of the plug in the vial.
  • a resilient plug with (a) an inwardly tapered base, (b) a top flange, and (c) a body extending from the base to the top flange and having an outer diameter that corresponds to or is only slightly greater than the first inner diameter of the vial, assuring an interference fit between the plug and the vial, thereby sealing the plug inside the vial upon insertion of the plug in the vial.
  • FIG. 1A illustrates a vial and plug combination in accordance with the present invention
  • FIG. 1B illustrates a conventional crimp vial with its seal in place
  • FIG. 1C illustrates a conventional threaded vial with its closure in place
  • FIG. 1D illustrates a conventional shell vial with its plug in place
  • FIG. 2A illustrates the vial shown in FIG. 1A with the plug removed and as the vial is being filled using a pipette;
  • FIG. 2B illustrates the crimp vial shown in FIG. 1B with the seal removed and as the vial is being filled using a pipette;
  • FIG. 2C illustrates the threaded vial shown in FIG. 1C with the closure removed and as the vial is being filled using a pipette;
  • FIG. 2D illustrates the shell vial shown in FIG. 1D with the plug removed and as the vial is being filled using a pipette
  • FIG. 3 is an expanded view of the vial and plug combination shown in FIG. 1A, with the plug illustrated in side view and separated from the vial illustrated in perspective view;
  • FIG. 4 is a top view of the vial illustrated in FIG. 3;
  • FIG. 5 is a cross-sectional view of the vial shown in FIG. 3, taken along the line 5 - 5 of FIG. 4;
  • FIG. 6 is a side view of the vial shown in FIG. 3;
  • FIG. 7 is a top view of the plug illustrated in FIG. 3;
  • FIG. 8 is a cross-sectional view of the plug shown in FIG. 3, taken along the line 8 - 8 of FIG. 7;
  • FIG. 9 is a side view of the plug shown in FIG. 3;
  • FIG. 10A illustrates a tubular filter upon insertion into the vial of the present invention having an unfiltered solution
  • FIG. 10B illustrates the tubular filter shown in FIG. 10A in place within the vial as sealed by the plug of the present invention, yielding a filtered solution
  • FIG. 11A illustrates a hollow tubular filter upon insertion into the vial of the present invention having an unfiltered solution
  • FIG. 11B illustrates the hollow tubular filter shown in FIG. 11A in place within the vial as sealed by the plug of the present invention, yielding a filtered solution.
  • FIG. 3 shows the vial and plug combination 50 in accordance with the present invention.
  • Vial and plug combination 50 includes a vial 10 and a resilient plug 30 having an axis, a.
  • Vial 10 may be plastic or glass.
  • Plug 30 is a resilient plastic.
  • vial 10 has three (typically integral or monolithic) sections: a head 12 defining a first chamber, a body 16 defining a second chamber, and a neck 14 disposed between head 12 and body 16 .
  • Head 12 extends between a top 18 , with a center opening 20 , and a lower shoulder 22 .
  • Body 16 extends between a base 24 and an upper shoulder 26 .
  • the walls of vial 10 are about 0.084 cm (0.033 inches) thick.
  • the total length of vial 10 between base 24 and top 18 is about 3.188 cm (1.255 inches).
  • the length of head 12 , the distance between lower shoulder 22 and top 18 is about 0.533 cm (0.210 inches).
  • the distance between upper shoulder 26 and top 18 is about 1.031 cm (0.406 inches).
  • the ID and outer diameter (or “OD”) of the chambers defined by head 12 and body 16 are substantially equal.
  • the ID is about 0.965 cm (0.380 inches) and the OD is about 1.160 cm (0.457 inches).
  • Neck 14 extends between lower shoulder 22 of head 12 and upper shoulder 26 of body 16 , providing a recessed robotic arm pick up area 90 adapted for engagement by automatic equipment. This robotic arm pick up area 90 is highlighted in FIG. 1A.
  • the ID and OD of neck 14 are substantially less than the ID and OD common to head 12 and body 16 . In the exemplary embodiment, the OD of neck 14 is about 0.856 cm (0.337 inches).
  • lower shoulder 22 and upper shoulder 26 are defined by sharp angles. It may be advantageous, however, to round those angles. Therefore, the alternative embodiment shown in FIGS. 5 and 6 illustrates vial 10 having curved transitions between lower shoulder 22 of head 12 and neck 14 and between neck 14 and upper shoulder 26 of body 16 .
  • Head 12 has a protrusion 80 adjacent top 18 .
  • the length of protrusion 80 is about 0.079 cm (0.031 inches).
  • Protrusion 80 functions to form a catch or undercut, facilitating retention of plug 30 in vial 10 .
  • the relatively large ID of head 12 defined by the diameter of center opening 20 and the first chamber, in comparison to conventional vials, permits the user to fill vial 10 easily. Such filling is typically done using a pipette, as shown in FIG. 2A.
  • This characteristic of vial 10 offers a major advantage over conventional vials, especially those used in chromatograghy applications.
  • plug 30 has three (typically integral or monolithic) sections: a top flange 32 , a body 34 , and an inwardly tapered base 36 .
  • Plug 30 may be made of silicone rubber, butyl rubber, natural rubber or any other resilient material which can be used as molded or bonded to an inert material such as polytetrafluoroethylene (sold under the trademark Teflon of E. I. DuPont deNemours & Co., Inc. of Wilmington, Del.).
  • Polytetrafluoroethylene is “a highly stable thermoplastic tetrafluoroethylene homopolymer composed of at least 20,000C 2 F 4 monomer units linked into very long unbranched chains.” Merck Index at 7560.
  • top flange 32 of plug 30 has an underside 44 and a central opening 38 in which is disposed a central, upraised button 40 .
  • Button 40 can be pierced with an instrument needle and reseal itself after retraction of the needle. In fact, plug 30 assures excellent resealability of vial and plug combination 50 after multiple needle penetrations.
  • Button 40 can be provided with a slit 42 (preferably, but not essentially, an X-shaped slit) which permits plug 30 to be easily pierced with thin-walled instrument needles.
  • base 36 facilitates insertion of plug 30 into center opening 20 of vial 10 .
  • base 36 has an OD which is less than the ID of head 12 of vial 10 .
  • Body 34 extends vertically upward from base 36 to top flange 32 and facilitates alignment of plug 30 and vial 10 , as they are assembled.
  • the OD of body 34 might be constant (i.e., body 34 may be substantially vertical and straight), it is preferable that body 34 have a slight outward angular taper. An angular shape allows for tolerance variations and assures an interference fit between plug 30 and vial 10 , thereby sealing plug 30 inside vial 10 .
  • the thickness of button 40 is about 0.051 cm (0.02 inches).
  • the diameter of central opening 38 is about 0.813 cm (0.320 inches).
  • the length of flange 32 is about 0.152 cm (0.06 inches) and the width of flange 32 , which also defines the maximum width of plug 30 , is about 1.207 cm (0.475 inches).
  • the length of plug 30 between the top 46 and the bottom 48 is about 0.559 cm (0.220 inches) in the exemplary embodiment.
  • the length between top 46 and the flat portion 52 of button 40 is about 0.330 cm (0.130 inches).
  • the length between bottom 48 and the junction 54 , between body 34 and base 36 is about 0.152 cm (0.060 inches).
  • the diameter of base 36 is about 1.029 cm (0.405 inches) and the diameter of the base 36 between apical points 56 is about 0.770 cm (0.303 inches).
  • the diameter of plug 30 at the points where underside 44 contacts body 34 is about 1 cm (0.390 inches).
  • the user aligns base 36 of plug 30 with center opening 20 of head 12 of vial 10 and pushes downward on plug 30 .
  • the resultant downward movement of plug 30 toward vial 10 causes body 36 of plug 30 to engage the walls of head 12 of vial 10 defining the first chamber.
  • the downward force overcomes the friction generated by the interference fit and is maintained by the user until underside 44 of top flange 32 contacts top 18 of head 12 .
  • plug 30 is fully inserted into vial 10 .
  • a tactile (and, at least on occasion, an audible) seating informs the user that insertion has been completed.
  • vial and plug combination 50 permits ease of sealing vial 10 by simply pushing plug 30 into the ID of head 12 of vial 10 .
  • the integrity of the seal between vial 10 and plug 30 provides another advantage to vial and plug combination 50 .
  • in-house tests conducted with a volatile solvent showed evaporation loss equivalent to that of a crimped aluminum seal.
  • vial and plug combination 50 can be used in long-term storage.
  • FIGS. 10A and 11A illustrate tubular filter 70 and hollow tubular filter 78 , respectively, upon insertion into vial 10 having an unfiltered solution 72 . As shown in FIGS.
  • tubular filter 70 and hollow tubular filter 78 are in place within vial 10 as sealed by plug 30 , yielding a filtered solution 74 . Therefore, vial and plug combination 50 offers improved economy: the conventional three-piece syringe, plunger, and filter are replaced with one unit.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Closures For Containers (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
US10/320,981 2001-12-27 2002-12-17 Versatile vial and plug system Abandoned US20030121878A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US10/320,981 US20030121878A1 (en) 2001-12-27 2002-12-17 Versatile vial and plug system
EP02028893A EP1325875A3 (de) 2001-12-27 2002-12-23 Vielseitiges Fläschen und Stöpsel System

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34376001P 2001-12-27 2001-12-27
US10/320,981 US20030121878A1 (en) 2001-12-27 2002-12-17 Versatile vial and plug system

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US10/320,981 Abandoned US20030121878A1 (en) 2001-12-27 2002-12-17 Versatile vial and plug system

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EP (1) EP1325875A3 (de)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070284330A1 (en) * 2006-06-07 2007-12-13 J.G. Finneran Associates, Inc. Two-piece seal vial assembly
CN102401885A (zh) * 2010-09-08 2012-04-04 黄山学院 磁化率管
JP2014041045A (ja) * 2012-08-22 2014-03-06 Sysmex Corp 試薬容器
WO2014136676A1 (ja) * 2013-03-03 2014-09-12 Kakuda Shinichiro 押し栓構造を備えたストッパー付きチューブ
KR20140138668A (ko) * 2012-02-02 2014-12-04 벡톤 디킨슨 홀딩즈 피티이 엘티디. 의료용 용기와 결합하기 위한 어댑터
US20180280238A1 (en) * 2017-03-28 2018-10-04 B. Braun Melsungen Ag Securing device for securing an infusion appliance
WO2019089187A1 (en) * 2017-10-05 2019-05-09 Derek Domenici Inhalation device
US10578527B2 (en) * 2015-03-16 2020-03-03 Chopin Technologies Test system comprising a heating device and method for implementing a test system
US20210300643A1 (en) * 2016-09-28 2021-09-30 Fresenius Kabi Deutschland Gmbh Sealing cap for a container for holding a medical liquid

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US20190329248A1 (en) * 2016-02-08 2019-10-31 Nolato Treff Ag Degersheim Vial, method for transporting vials, and use of a vial

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US3900122A (en) * 1972-07-21 1975-08-19 Dichter Hans Joachim Containers with stoppers
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US4872572A (en) * 1987-12-24 1989-10-10 Helvoet Pharma N.V. Lyophilization stopper (case II)
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US1115597A (en) * 1912-05-06 1914-11-03 George H Sherman Vaccine-container.
US2923427A (en) * 1956-05-04 1960-02-02 Klopfenstein Florenc Stoianoff Closure for hypodermic solution containers
US3900122A (en) * 1972-07-21 1975-08-19 Dichter Hans Joachim Containers with stoppers
US4227620A (en) * 1979-02-28 1980-10-14 Becton, Dickinson And Company Specimen collecting tube
US4872572A (en) * 1987-12-24 1989-10-10 Helvoet Pharma N.V. Lyophilization stopper (case II)
US6024235A (en) * 1991-04-13 2000-02-15 Dade Behring Marburg Gmbh Container seal with a sealing body which can be punctured

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070284330A1 (en) * 2006-06-07 2007-12-13 J.G. Finneran Associates, Inc. Two-piece seal vial assembly
US7934614B2 (en) * 2006-06-07 2011-05-03 J. G. Finneran Associates, Inc. Two-piece seal vial assembly
CN102401885A (zh) * 2010-09-08 2012-04-04 黄山学院 磁化率管
US9668939B2 (en) 2012-02-02 2017-06-06 Becton Dickinson Holdings Pte. Ltd. Adaptor for coupling with a medical container
KR20140138668A (ko) * 2012-02-02 2014-12-04 벡톤 디킨슨 홀딩즈 피티이 엘티디. 의료용 용기와 결합하기 위한 어댑터
CN104203194A (zh) * 2012-02-02 2014-12-10 碧迪股份有限公司 用于与医用容器相联接的适配器
JP2015506254A (ja) * 2012-02-02 2015-03-02 ベクトン ディキンソン ホールディングス ピーティーイー リミテッド 医療用容器と接続するためのアダプタ
US10751252B2 (en) 2012-02-02 2020-08-25 Becton Dickinson Holdings Pte. Ltd. Adaptor for coupling with a medical container
KR101986869B1 (ko) * 2012-02-02 2019-06-07 벡톤 디킨슨 홀딩즈 피티이 엘티디. 의료용 용기와 결합하기 위한 어댑터
JP2014041045A (ja) * 2012-08-22 2014-03-06 Sysmex Corp 試薬容器
WO2014136676A1 (ja) * 2013-03-03 2014-09-12 Kakuda Shinichiro 押し栓構造を備えたストッパー付きチューブ
JP5658849B1 (ja) * 2013-03-03 2015-01-28 新一郎 角田 押し栓構造を備えたストッパー付きチューブ
US10578527B2 (en) * 2015-03-16 2020-03-03 Chopin Technologies Test system comprising a heating device and method for implementing a test system
US12116188B2 (en) * 2016-09-28 2024-10-15 Fresenius Kabi Deutschland Gmbh Sealing cap for a container for holding a medical liquid
US20210300643A1 (en) * 2016-09-28 2021-09-30 Fresenius Kabi Deutschland Gmbh Sealing cap for a container for holding a medical liquid
US20180280238A1 (en) * 2017-03-28 2018-10-04 B. Braun Melsungen Ag Securing device for securing an infusion appliance
US11197801B2 (en) * 2017-03-28 2021-12-14 B. Braun Melsungen Ag Securing device for securing an infusion appliance
CN108653874A (zh) * 2017-03-28 2018-10-16 B.布劳恩梅尔松根股份公司 用于固定输注器件的固定装置
CN111417321A (zh) * 2017-10-05 2020-07-14 德里克·多梅尼西 吸入装置
WO2019089187A1 (en) * 2017-10-05 2019-05-09 Derek Domenici Inhalation device

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EP1325875A3 (de) 2004-10-27
EP1325875A2 (de) 2003-07-09

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