US20030068276A1 - Dosage forms - Google Patents

Dosage forms Download PDF

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Publication number
US20030068276A1
US20030068276A1 US10/016,336 US1633601A US2003068276A1 US 20030068276 A1 US20030068276 A1 US 20030068276A1 US 1633601 A US1633601 A US 1633601A US 2003068276 A1 US2003068276 A1 US 2003068276A1
Authority
US
United States
Prior art keywords
dosage form
pharmaceutical dosage
oral pharmaceutical
abuse
schedule
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10/016,336
Other languages
English (en)
Inventor
Lyn Hughes
Simon Bellamy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rohm and Haas Co
Original Assignee
Rohm and Haas Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rohm and Haas Co filed Critical Rohm and Haas Co
Priority to US10/016,336 priority Critical patent/US20030068276A1/en
Priority to EP02256157A priority patent/EP1293195A1/de
Priority to KR1020020054861A priority patent/KR20030024583A/ko
Priority to JP2002269709A priority patent/JP2003113074A/ja
Publication of US20030068276A1 publication Critical patent/US20030068276A1/en
Priority to US10/679,785 priority patent/US7655256B2/en
Priority to US10/713,926 priority patent/US20040126428A1/en
Assigned to ROHM AND HAAS COMPANY reassignment ROHM AND HAAS COMPANY ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BELLAMY, SIMON ANDREW, HUGHES, LYN
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
US10/016,336 2001-09-17 2001-11-02 Dosage forms Abandoned US20030068276A1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US10/016,336 US20030068276A1 (en) 2001-09-17 2001-11-02 Dosage forms
EP02256157A EP1293195A1 (de) 2001-09-17 2002-09-05 Orale pharmazeutische Darreichungsformen mit reduziertem Drogenmissbrauchspotential, respiratorische Reizstoffe oder Bitterstoffe enthaltend
KR1020020054861A KR20030024583A (ko) 2001-09-17 2002-09-11 제형
JP2002269709A JP2003113074A (ja) 2001-09-17 2002-09-17 投薬フォーム
US10/679,785 US7655256B2 (en) 2001-09-17 2003-10-06 Pharmaceutical formulation including a resinate and an aversive agent
US10/713,926 US20040126428A1 (en) 2001-11-02 2003-11-14 Pharmaceutical formulation including a resinate and an aversive agent

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32262401P 2001-09-17 2001-09-17
US10/016,336 US20030068276A1 (en) 2001-09-17 2001-11-02 Dosage forms

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10/679,785 Continuation-In-Part US7655256B2 (en) 2001-09-17 2003-10-06 Pharmaceutical formulation including a resinate and an aversive agent
US10/713,926 Continuation-In-Part US20040126428A1 (en) 2001-11-02 2003-11-14 Pharmaceutical formulation including a resinate and an aversive agent

Publications (1)

Publication Number Publication Date
US20030068276A1 true US20030068276A1 (en) 2003-04-10

Family

ID=26688465

Family Applications (2)

Application Number Title Priority Date Filing Date
US10/016,336 Abandoned US20030068276A1 (en) 2001-09-17 2001-11-02 Dosage forms
US10/679,785 Expired - Fee Related US7655256B2 (en) 2001-09-17 2003-10-06 Pharmaceutical formulation including a resinate and an aversive agent

Family Applications After (1)

Application Number Title Priority Date Filing Date
US10/679,785 Expired - Fee Related US7655256B2 (en) 2001-09-17 2003-10-06 Pharmaceutical formulation including a resinate and an aversive agent

Country Status (4)

Country Link
US (2) US20030068276A1 (de)
EP (1) EP1293195A1 (de)
JP (1) JP2003113074A (de)
KR (1) KR20030024583A (de)

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US20030068392A1 (en) * 2001-08-06 2003-04-10 Richard Sackler Pharmaceutical formulation containing opioid agonist, opioid antagonist and irritant
US20030068375A1 (en) * 2001-08-06 2003-04-10 Curtis Wright Pharmaceutical formulation containing gelling agent
US20030091635A1 (en) * 2001-09-26 2003-05-15 Baichwal Anand R. Opioid formulations having reduced potential for abuse
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US20040131552A1 (en) * 2002-09-20 2004-07-08 Alpharma, Inc. Sequestering subunit and related compositions and methods
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US20060039864A1 (en) * 2004-07-01 2006-02-23 Johannes Bartholomaus Abuse-proofed oral dosage form
US20060110327A1 (en) * 2004-11-24 2006-05-25 Acura Pharmaceuticals, Inc. Methods and compositions for deterring abuse of orally administered pharmaceutical products
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US20060188447A1 (en) * 2005-02-04 2006-08-24 Elisabeth Arkenau-Maric Process for the production of an abuse-proofed dosage form
WO2006125819A2 (fr) * 2005-05-24 2006-11-30 Flamel Technologies Forme medicamenteuse orale, microparticulaire, anti-mesusage
US20070003616A1 (en) * 2003-12-24 2007-01-04 Elisabeth Arkenau-Maric Process for the production of an abuse-proofed dosage form
US20070048228A1 (en) * 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
US20070098794A1 (en) * 2001-07-06 2007-05-03 Haui-Hung Kao Oxymorphone controlled release formulations
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US20070183980A1 (en) * 2003-08-06 2007-08-09 Elisabeth Arkenau-Maric Dosage form that is safeguarded from abuse
US20070212414A1 (en) * 2006-03-08 2007-09-13 Penwest Pharmaceuticals Co. Ethanol-resistant sustained release formulations
US20070231268A1 (en) * 2004-11-24 2007-10-04 Acura Pharmaceuticals, Inc. Methods and compositions for deterring abuse of orally administered pharmaceutical products
WO2007135193A2 (fr) * 2006-05-24 2007-11-29 Flamel Technologies Forme pharmaceutique orale multimicroparticulaire a liberation prolongee comprenant des moyens anti-mesusage et resistant a l'alcool
US20080020032A1 (en) * 2006-07-21 2008-01-24 Michael Crowley Hydrophobic abuse deterrent delivery system for hydromorphone
US20080152595A1 (en) * 2004-11-24 2008-06-26 Acura Pharmaceuticals, Inc. Methods and compositions for deterring abuse of orally administered pharmaceutical products
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US7655256B2 (en) 2010-02-02
KR20030024583A (ko) 2003-03-26

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